Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.0 0.088 -9999.0 0.0 -0.182 86.0 86.0 epithelial cell differentiation 0.029 0.059 -9999.0 0.0 -0.117 67.0 67.0 CYFIP2 0.02 0.018 -9999.0 0.0 -0.122 8.0 8.0 ENAH 0.009 0.056 -9999.0 0.0 -0.134 51.0 51.0 EGFR 0.015 0.03 -9999.0 0.0 -0.122 25.0 25.0 EPHA2 0.02 0.022 -9999.0 0.0 -0.122 13.0 13.0 MYO6 0.01 0.057 -9999.0 0.0 -0.125 67.0 67.0 CTNNB1 0.022 0.008 -9999.0 0.0 -0.122 1.0 1.0 ABI1/Sra1/Nap1 0.03 0.05 -9999.0 0.0 -0.117 53.0 53.0 AQP5 -0.059 0.146 -9999.0 0.0 -0.321 122.0 122.0 CTNND1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.015 0.049 -9999.0 0.0 -0.106 67.0 67.0 regulation of calcium-dependent cell-cell adhesion 0.014 0.05 -9999.0 0.0 -0.107 67.0 67.0 EGF 0.02 0.021 -9999.0 0.0 -0.122 12.0 12.0 NCKAP1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.012 0.076 -9999.0 0.0 -0.284 24.0 24.0 cortical microtubule organization 0.029 0.059 -9999.0 0.0 -0.117 67.0 67.0 GO:0000145 0.008 0.045 -9999.0 0.0 -0.101 67.0 67.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.033 0.061 -9999.0 0.0 -0.118 67.0 67.0 MLLT4 0.014 0.032 -9999.0 0.0 -0.122 29.0 29.0 ARF6/GDP -0.022 0.05 -9999.0 0.0 -0.17 43.0 43.0 ARF6 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.029 0.062 -9999.0 0.0 -0.109 75.0 75.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.015 0.058 -9999.0 0.0 -0.185 30.0 30.0 PVRL2 0.019 0.023 -9999.0 0.0 -0.122 15.0 15.0 ZYX 0.011 0.054 -9999.0 0.0 -0.118 67.0 67.0 ARF6/GTP 0.035 0.063 -9999.0 0.0 -0.101 80.0 80.0 CDH1 0.021 0.016 -9999.0 0.0 -0.122 6.0 6.0 EGFR/EGFR/EGF/EGF 0.015 0.062 -9999.0 0.0 -0.193 24.0 24.0 RhoA/GDP 0.03 0.058 -9999.0 0.0 -0.21 16.0 16.0 actin cytoskeleton organization 0.009 0.059 -9999.0 0.0 -0.131 66.0 66.0 IGF-1R heterotetramer 0.013 0.032 -9999.0 0.0 -0.122 28.0 28.0 GIT1 0.022 0.012 -9999.0 0.0 -0.122 4.0 4.0 IGF1R 0.013 0.032 -9999.0 0.0 -0.122 28.0 28.0 IGF1 0.007 0.045 -9999.0 0.0 -0.122 60.0 60.0 DIAPH1 -0.022 0.204 -9999.0 0.0 -0.556 70.0 70.0 Wnt receptor signaling pathway -0.029 0.059 0.117 67.0 -9999.0 0.0 67.0 RHOA 0.023 0.006 -9999.0 0.0 -0.122 1.0 1.0 RhoA/GTP -0.022 0.049 -9999.0 0.0 -0.169 42.0 42.0 CTNNA1 0.022 0.01 -9999.0 0.0 -0.122 2.0 2.0 VCL 0.009 0.061 -9999.0 0.0 -0.134 66.0 66.0 EFNA1 0.014 0.031 -9999.0 0.0 -0.122 26.0 26.0 LPP 0.012 0.054 -9999.0 0.0 -0.192 23.0 23.0 Ephrin A1/EPHA2 0.012 0.064 -9999.0 0.0 -0.186 28.0 28.0 SEC6/SEC8 -0.02 0.049 -9999.0 0.0 -0.189 32.0 32.0 MGAT3 0.014 0.051 -9999.0 0.0 -0.109 67.0 67.0 HGF/MET -0.006 0.071 -9999.0 0.0 -0.179 45.0 45.0 HGF 0.02 0.023 -9999.0 0.0 -0.122 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.0 0.089 -9999.0 0.0 -0.183 86.0 86.0 actin cable formation 0.012 0.08 -9999.0 0.0 -0.193 49.0 49.0 KIAA1543 0.013 0.05 -9999.0 0.0 -0.176 23.0 23.0 KIFC3 0.015 0.05 -9999.0 0.0 -0.107 67.0 67.0 NCK1 0.02 0.019 -9999.0 0.0 -0.122 9.0 9.0 EXOC3 0.023 0.009 -9999.0 0.0 -0.122 2.0 2.0 ACTN1 0.013 0.057 -9999.0 0.0 -0.12 67.0 67.0 NCK1/GIT1 0.022 0.043 -9999.0 0.0 -0.121 45.0 45.0 mol:GDP 0.029 0.059 -9999.0 0.0 -0.117 67.0 67.0 EXOC4 0.022 0.007 -9999.0 0.0 -0.122 1.0 1.0 STX4 0.014 0.052 -9999.0 0.0 -0.11 67.0 67.0 PIP5K1C 0.015 0.05 -9999.0 0.0 -0.107 67.0 67.0 LIMA1 0.019 0.023 -9999.0 0.0 -0.122 14.0 14.0 ABI1 0.022 0.009 -9999.0 0.0 -0.122 2.0 2.0 ROCK1 0.011 0.06 -9999.0 0.0 -0.161 39.0 39.0 adherens junction assembly 0.022 0.059 -9999.0 0.0 -0.228 15.0 15.0 IGF-1R heterotetramer/IGF1 -0.0 0.071 -9999.0 0.0 -0.169 47.0 47.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.013 0.054 -9999.0 0.0 -0.146 43.0 43.0 MET 0.0 0.047 -9999.0 0.0 -0.122 70.0 70.0 PLEKHA7 0.013 0.052 -9999.0 0.0 -0.114 67.0 67.0 mol:GTP 0.028 0.061 -9999.0 0.0 -0.109 75.0 75.0 establishment of epithelial cell apical/basal polarity 0.013 0.062 -9999.0 0.0 -0.178 34.0 34.0 cortical actin cytoskeleton stabilization 0.0 0.088 -9999.0 0.0 -0.182 86.0 86.0 regulation of cell-cell adhesion 0.009 0.059 -9999.0 0.0 -0.131 66.0 66.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.0 0.089 -9999.0 0.0 -0.183 86.0 86.0