S1P3 pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PDGFRB 0.01 0.042 -9999.0 0.0 -0.122 52.0 52.0 mol:S1P -0.002 0.007 -9999.0 0.0 -0.029 24.0 24.0 S1P1/S1P/Gi 0.008 0.065 -9999.0 0.0 -0.224 31.0 31.0 GNAO1 0.008 0.043 -9999.0 0.0 -0.125 51.0 51.0 S1P/S1P3/G12/G13 0.024 0.024 -9999.0 0.0 -0.097 16.0 16.0 AKT1 0.006 0.059 -9999.0 0.0 -0.355 7.0 7.0 AKT3 -0.054 0.227 -9999.0 0.0 -1.049 24.0 24.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PDGFB-D/PDGFRB 0.01 0.042 -9999.0 0.0 -0.122 52.0 52.0 GNAI2 0.02 0.014 -9999.0 0.0 -0.044 15.0 15.0 GNAI3 0.02 0.012 -9999.0 0.0 -0.121 1.0 1.0 GNAI1 0.01 0.036 -9999.0 0.0 -0.124 35.0 35.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 S1PR3 -0.002 0.008 -9999.0 0.0 -0.031 24.0 24.0 S1PR2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EDG1 0.021 0.016 -9999.0 0.0 -0.122 7.0 7.0 mol:Ca2+ -0.016 0.088 -9999.0 0.0 -0.223 55.0 55.0 MAPK3 -0.012 0.084 -9999.0 0.0 -0.221 52.0 52.0 MAPK1 -0.013 0.085 -9999.0 0.0 -0.222 51.0 51.0 JAK2 -0.023 0.102 -9999.0 0.0 -0.25 69.0 69.0 CXCR4 -0.021 0.092 -9999.0 0.0 -0.235 62.0 62.0 FLT1 0.019 0.019 -9999.0 0.0 -0.06 18.0 18.0 RhoA/GDP 0.016 0.016 -9999.0 0.0 -0.135 6.0 6.0 Rac1/GDP 0.016 0.015 -9999.0 0.0 -0.147 5.0 5.0 SRC -0.012 0.083 -9999.0 0.0 -0.221 49.0 49.0 S1P/S1P3/Gi -0.016 0.089 -9999.0 0.0 -0.224 55.0 55.0 RAC1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.005 0.085 -9999.0 0.0 -0.223 46.0 46.0 VEGFA 0.017 0.024 -9999.0 0.0 -0.122 11.0 11.0 S1P/S1P2/Gi -0.011 0.076 -9999.0 0.0 -0.149 106.0 106.0 VEGFR1 homodimer/VEGFA homodimer 0.016 0.055 -9999.0 0.0 -0.148 44.0 44.0 RHOA 0.023 0.006 -9999.0 0.0 -0.122 1.0 1.0 S1P/S1P3/Gq 0.014 0.045 -9999.0 0.0 -0.15 34.0 34.0 GNAQ 0.021 0.016 -9999.0 0.0 -0.122 6.0 6.0 GNAZ 0.02 0.014 -9999.0 0.0 -0.031 24.0 24.0 G12/G13 0.03 0.028 -9999.0 0.0 -0.132 16.0 16.0 GNA14 0.02 0.02 -9999.0 0.0 -0.122 11.0 11.0 GNA15 0.021 0.017 -9999.0 0.0 -0.122 8.0 8.0 GNA12 0.023 0.001 -9999.0 0.0 -9999.0 0.0 0.0 GNA13 0.022 0.009 -9999.0 0.0 -0.122 2.0 2.0 GNA11 0.022 0.014 -9999.0 0.0 -0.122 5.0 5.0 Rac1/GTP -0.005 0.085 -9999.0 0.0 -0.225 46.0 46.0