Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MET/RANBP9 0.011 0.075 -9999.0 0.0 -0.137 101.0 101.0 CRKL -0.024 0.133 0.278 3.0 -0.42 34.0 37.0 mol:PIP3 0.003 0.109 -9999.0 0.0 -0.83 8.0 8.0 AKT1 -0.003 0.105 0.372 2.0 -0.737 8.0 10.0 PTK2B 0.034 0.016 -9999.0 0.0 0.0 97.0 97.0 RAPGEF1 -0.028 0.126 0.307 1.0 -0.396 34.0 35.0 RANBP10 0.037 0.013 -9999.0 0.0 0.0 58.0 58.0 PIK3CA 0.029 0.019 -9999.0 0.0 0.0 166.0 166.0 HGF/MET/SHIP2 0.028 0.076 -9999.0 0.0 -0.116 100.0 100.0 MAP3K5 -0.014 0.128 0.255 2.0 -0.388 33.0 35.0 HGF/MET/CIN85/CBL/ENDOPHILINS 0.049 0.083 -9999.0 0.0 -0.109 101.0 101.0 AP1 -0.004 0.081 0.158 11.0 -0.138 105.0 116.0 mol:SU11274 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.039 0.008 -9999.0 0.0 0.0 23.0 23.0 apoptosis -0.155 0.347 -9999.0 0.0 -0.764 130.0 130.0 STAT3 (dimer) -0.006 0.107 0.188 5.0 -0.204 82.0 87.0 GAB1/CRKL/SHP2/PI3K -0.006 0.138 -9999.0 0.0 -0.382 37.0 37.0 INPP5D 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CBL/CRK -0.004 0.138 0.294 2.0 -0.395 34.0 36.0 PTPN11 0.039 0.009 -9999.0 0.0 0.0 29.0 29.0 GO:0007205 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLCG1 0.038 0.011 -9999.0 0.0 0.0 43.0 43.0 PTEN 0.038 0.01 -9999.0 0.0 0.0 36.0 36.0 ELK1 0.011 0.115 0.32 46.0 -9999.0 0.0 46.0 mol:SU5416 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHP2/GRB2/SOS1GAB1 -0.011 0.081 0.145 2.0 -0.208 45.0 47.0 PAK1 0.004 0.112 0.35 5.0 -0.678 8.0 13.0 HGF/MET/RANBP10 0.025 0.075 -9999.0 0.0 -0.113 101.0 101.0 HRAS -0.072 0.213 -9999.0 0.0 -0.476 115.0 115.0 DOCK1 -0.029 0.131 0.248 7.0 -0.39 37.0 44.0 GAB1 -0.023 0.136 -9999.0 0.0 -0.435 34.0 34.0 CRK -0.022 0.131 0.29 2.0 -0.415 33.0 35.0 mol:PHA665752 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.054 0.188 -9999.0 0.0 -0.418 109.0 109.0 JUN 0.035 0.014 -9999.0 0.0 0.0 76.0 76.0 EntrezGene:200958 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.019 0.07 0.094 4.0 -0.161 100.0 104.0 PIK3R1 0.034 0.016 -9999.0 0.0 0.0 99.0 99.0 cell morphogenesis -0.0 0.147 0.273 36.0 -0.322 39.0 75.0 GRB2/SHC 0.018 0.094 -9999.0 0.0 -0.161 104.0 104.0 FOS 0.026 0.02 -9999.0 0.0 0.0 201.0 201.0 GLMN 0.005 0.006 0.068 5.0 -9999.0 0.0 5.0 cell motility 0.011 0.115 0.318 46.0 -9999.0 0.0 46.0 HGF/MET/MUC20 0.015 0.062 -9999.0 0.0 -0.108 102.0 102.0 cell migration 0.017 0.093 -9999.0 0.0 -0.159 104.0 104.0 GRB2 0.04 0.008 -9999.0 0.0 0.0 21.0 21.0 CBL 0.04 0.008 -9999.0 0.0 0.0 20.0 20.0 MET/RANBP10 0.011 0.073 -9999.0 0.0 -0.131 102.0 102.0 HGF/MET/Paxillin/FAK1/FAK12/RasGAP -0.015 0.08 -9999.0 0.0 -0.176 79.0 79.0 MET/MUC20 -0.004 0.06 -9999.0 0.0 -0.125 104.0 104.0 RAP1B -0.028 0.118 0.332 2.0 -0.371 32.0 34.0 RAP1A -0.032 0.123 0.338 2.0 -0.382 35.0 37.0 HGF/MET/RANBP9 0.027 0.077 -9999.0 0.0 -0.118 99.0 99.0 RAF1 -0.07 0.206 -9999.0 0.0 -0.456 115.0 115.0 STAT3 -0.007 0.105 -9999.0 0.0 -0.203 82.0 82.0 cell proliferation -0.03 0.136 0.254 11.0 -0.277 97.0 108.0 RPS6KB1 -0.01 0.082 -9999.0 0.0 -0.281 33.0 33.0 MAPK3 -0.008 0.118 0.56 15.0 -9999.0 0.0 15.0 MAPK1 0.021 0.185 0.712 31.0 -9999.0 0.0 31.0 RANBP9 0.038 0.012 -9999.0 0.0 0.0 47.0 47.0 MAPK8 -0.011 0.14 -9999.0 0.0 -0.409 36.0 36.0 SRC -0.004 0.093 0.203 10.0 -0.178 81.0 91.0 PI3K 0.002 0.092 -9999.0 0.0 -0.177 88.0 88.0 MET/Glomulin 0.011 0.047 -9999.0 0.0 -0.121 45.0 45.0 SOS1 0.037 0.012 -9999.0 0.0 0.0 51.0 51.0 MAP2K1 -0.071 0.192 -9999.0 0.0 -0.43 115.0 115.0 MET 0.027 0.02 -9999.0 0.0 0.0 191.0 191.0 MAP4K1 -0.011 0.134 0.271 2.0 -0.427 30.0 32.0 PTK2 0.027 0.019 -9999.0 0.0 0.0 182.0 182.0 MAP2K2 -0.07 0.189 -9999.0 0.0 -0.424 115.0 115.0 BAD -0.008 0.1 0.334 2.0 -0.707 8.0 10.0 MAP2K4 -0.016 0.118 0.258 1.0 -0.358 33.0 34.0 SHP2/GRB2/SOS1/GAB1 -0.009 0.146 -9999.0 0.0 -0.351 47.0 47.0 INPPL1 0.039 0.009 -9999.0 0.0 0.0 27.0 27.0 PXN 0.04 0.006 -9999.0 0.0 0.0 10.0 10.0 SH3KBP1 0.04 0.007 -9999.0 0.0 0.0 16.0 16.0 HGS -0.026 0.071 0.082 4.0 -0.161 109.0 113.0 PLCgamma1/PKC 0.026 0.02 -9999.0 0.0 -0.125 8.0 8.0 HGF 0.039 0.009 -9999.0 0.0 0.0 27.0 27.0 RASA1 0.037 0.013 -9999.0 0.0 0.0 56.0 56.0 NCK1 0.036 0.014 -9999.0 0.0 0.0 70.0 70.0 PTPRJ 0.039 0.01 -9999.0 0.0 0.0 33.0 33.0 NCK/PLCgamma1 0.014 0.097 -9999.0 0.0 -0.166 104.0 104.0 PDPK1 -0.004 0.103 -9999.0 0.0 -0.774 8.0 8.0 HGF/MET/SHIP 0.015 0.062 -9999.0 0.0 -0.108 102.0 102.0