IL12-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations IL12/IL12R/TYK2/JAK2/SOCS1 0.027 0.102 0.214 14.0 -0.258 26.0 40.0 TBX21 -0.026 0.273 -9999.0 0.0 -0.729 44.0 44.0 B2M 0.038 0.013 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.024 0.043 -9999.0 0.0 -0.051 76.0 76.0 IL12RB1 0.023 0.044 -9999.0 0.0 -0.054 71.0 71.0 GADD45B -0.058 0.343 -9999.0 0.0 -0.835 65.0 65.0 IL12RB2 0.027 0.045 -9999.0 0.0 -0.053 73.0 73.0 GADD45G -0.032 0.296 -9999.0 0.0 -0.763 52.0 52.0 natural killer cell activation 0.002 0.021 0.044 10.0 -0.036 65.0 75.0 RELB 0.039 0.01 -9999.0 0.0 0.0 33.0 33.0 RELA 0.04 0.006 -9999.0 0.0 0.0 10.0 10.0 IL18 0.03 0.024 -9999.0 0.0 -0.042 19.0 19.0 IL2RA 0.038 0.01 -9999.0 0.0 0.0 38.0 38.0 IFNG 0.037 0.013 -9999.0 0.0 0.0 58.0 58.0 STAT3 (dimer) -0.025 0.284 0.403 2.0 -0.626 67.0 69.0 HLA-DRB5 0.016 0.027 -9999.0 0.0 -0.006 297.0 297.0 FASLG -0.025 0.278 0.521 1.0 -0.743 44.0 45.0 NF kappa B2 p52/RelB -0.013 0.283 -9999.0 0.0 -0.636 64.0 64.0 CD4 0.025 0.028 -9999.0 0.0 -0.013 179.0 179.0 SOCS1 0.037 0.012 -9999.0 0.0 0.0 51.0 51.0 EntrezGene:6955 -0.001 0.01 -9999.0 0.0 -0.026 53.0 53.0 CD3D 0.026 0.03 -9999.0 0.0 -0.039 67.0 67.0 CD3E 0.028 0.029 -9999.0 0.0 -0.038 68.0 68.0 CD3G 0.025 0.029 -9999.0 0.0 -0.041 57.0 57.0 IL12Rbeta2/JAK2 0.029 0.074 -9999.0 0.0 -0.147 32.0 32.0 CCL3 -0.043 0.321 0.47 1.0 -0.834 54.0 55.0 CCL4 -0.03 0.273 -9999.0 0.0 -0.629 65.0 65.0 HLA-A 0.038 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IL18/IL18R 0.053 0.082 -9999.0 0.0 -0.116 75.0 75.0 NOS2 -0.026 0.266 0.381 2.0 -0.573 73.0 75.0 IL12/IL12R/TYK2/JAK2/SPHK2 0.027 0.103 0.213 16.0 -0.248 29.0 45.0 IL1R1 -0.109 0.428 -9999.0 0.0 -0.997 91.0 91.0 IL4 0.02 0.044 0.098 1.0 -0.061 13.0 14.0 JAK2 0.023 0.042 -9999.0 0.0 -0.053 65.0 65.0 EntrezGene:6957 -0.001 0.009 -9999.0 0.0 -0.025 26.0 26.0 TCR/CD3/MHC I/CD8 -0.013 0.112 -9999.0 0.0 -0.437 24.0 24.0 RAB7A -0.031 0.27 0.375 1.0 -0.582 77.0 78.0 lysosomal transport -0.027 0.26 0.366 2.0 -0.554 77.0 79.0 FOS -0.184 0.508 -9999.0 0.0 -1.07 123.0 123.0 STAT4 (dimer) -0.022 0.289 0.402 4.0 -0.631 69.0 73.0 STAT5A (dimer) -0.02 0.278 -9999.0 0.0 -0.633 64.0 64.0 GZMA -0.051 0.339 -9999.0 0.0 -0.93 51.0 51.0 GZMB -0.034 0.304 -9999.0 0.0 -0.854 43.0 43.0 HLX -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LCK -0.039 0.282 0.421 2.0 -0.664 64.0 66.0 TCR/CD3/MHC II/CD4 -0.066 0.197 -9999.0 0.0 -0.361 128.0 128.0 IL2/IL2R 0.045 0.08 -9999.0 0.0 -0.109 92.0 92.0 MAPK14 -0.047 0.32 -9999.0 0.0 -0.709 76.0 76.0 CCR5 -0.02 0.249 0.372 2.0 -0.536 72.0 74.0 IL1B 0.023 0.041 -9999.0 0.0 -0.052 62.0 62.0 STAT6 0.009 0.136 -9999.0 0.0 -0.515 15.0 15.0 STAT4 0.039 0.008 -9999.0 0.0 0.0 24.0 24.0 STAT3 0.038 0.011 -9999.0 0.0 0.0 41.0 41.0 STAT1 0.034 0.016 -9999.0 0.0 0.0 102.0 102.0 NFKB1 0.036 0.013 -9999.0 0.0 0.0 66.0 66.0 NFKB2 0.04 0.007 -9999.0 0.0 0.0 18.0 18.0 IL12B 0.027 0.045 -9999.0 0.0 -0.053 70.0 70.0 CD8A 0.042 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CD8B 0.001 0.0 -9999.0 0.0 -9999.0 0.0 0.0 T-helper 1 cell differentiation -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 natural killer cell mediated cytotoxicity -0.028 0.102 0.256 26.0 -0.212 16.0 42.0 IL2RB 0.035 0.014 -9999.0 0.0 0.0 76.0 76.0 proteasomal ubiquitin-dependent protein catabolic process -0.015 0.271 0.393 5.0 -0.583 69.0 74.0 IL2RG 0.028 0.019 -9999.0 0.0 0.0 179.0 179.0 IL12 0.024 0.072 -9999.0 0.0 -0.142 34.0 34.0 STAT5A 0.038 0.01 -9999.0 0.0 0.0 36.0 36.0 CD247 -0.001 0.009 -9999.0 0.0 -0.025 26.0 26.0 IL2 0.039 0.01 -9999.0 0.0 0.0 34.0 34.0 SPHK2 0.04 0.008 -9999.0 0.0 0.0 20.0 20.0 FRAP1 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 IL12A 0.02 0.04 -9999.0 0.0 -0.052 64.0 64.0 IL12/IL12R/TYK2/JAK2 -0.047 0.288 -9999.0 0.0 -0.698 65.0 65.0 MAP2K3 -0.05 0.332 0.408 1.0 -0.725 77.0 78.0 RIPK2 0.032 0.017 -9999.0 0.0 0.0 119.0 119.0 MAP2K6 -0.055 0.314 -9999.0 0.0 -0.682 80.0 80.0 regulation of dendritic cell antigen processing and presentation -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HLA-DRA 0.023 0.029 -9999.0 0.0 -0.012 203.0 203.0 IL18RAP 0.039 0.019 -9999.0 0.0 -0.041 23.0 23.0 IL12Rbeta1/TYK2 0.038 0.057 -9999.0 0.0 -0.092 1.0 1.0 EOMES 0.005 0.072 -9999.0 0.0 -0.563 6.0 6.0 STAT1 (dimer) -0.043 0.282 0.399 2.0 -0.598 80.0 82.0 T cell proliferation -0.021 0.234 0.347 6.0 -0.486 76.0 82.0 T-helper 1 cell lineage commitment -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL18R1 0.039 0.019 -9999.0 0.0 -0.041 22.0 22.0 CD8-positive alpha-beta T cell lineage commitment -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NF kappa B1 p50/RelA -0.029 0.248 -9999.0 0.0 -0.537 74.0 74.0 ATF2 -0.046 0.3 -9999.0 0.0 -0.657 78.0 78.0