Ceramide signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations SPHK2 -0.018 0.007 0.0 74.0 -9999.0 0.0 74.0 MAP4K4 -0.006 0.079 -9999.0 0.0 -0.248 29.0 29.0 BAG4 0.037 0.012 -9999.0 0.0 0.0 55.0 55.0 PKC zeta/ceramide 0.029 0.032 -9999.0 0.0 -0.176 9.0 9.0 NFKBIA 0.036 0.013 -9999.0 0.0 0.0 64.0 64.0 BIRC3 0.025 0.02 -9999.0 0.0 0.0 210.0 210.0 BAX 0.007 0.067 -9999.0 0.0 -0.341 19.0 19.0 RIPK1 0.039 0.01 -9999.0 0.0 0.0 32.0 32.0 AKT1 0.002 0.121 0.69 16.0 -9999.0 0.0 16.0 BAD -0.001 0.028 0.216 2.0 -0.183 7.0 9.0 SMPD1 0.008 0.059 0.156 15.0 -0.168 28.0 43.0 RB1 -0.003 0.043 0.201 8.0 -0.184 8.0 16.0 FADD/Caspase 8 -0.008 0.109 0.241 8.0 -0.306 41.0 49.0 MAP2K4 -0.007 0.028 -9999.0 0.0 -0.181 8.0 8.0 NSMAF 0.037 0.012 -9999.0 0.0 0.0 55.0 55.0 response to UV -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAF1 -0.003 0.042 0.185 15.0 -0.19 8.0 23.0 EGF 0.038 0.01 -9999.0 0.0 0.0 38.0 38.0 mol:ceramide 0.005 0.027 -9999.0 0.0 -0.181 9.0 9.0 MADD 0.041 0.005 -9999.0 0.0 0.0 9.0 9.0 response to oxidative stress 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Free Fatty acid -0.015 0.009 0.0 151.0 -9999.0 0.0 151.0 ASAH1 0.033 0.016 -9999.0 0.0 0.0 106.0 106.0 negative regulation of cell cycle -0.003 0.043 0.192 9.0 -0.183 8.0 17.0 cell proliferation 0.026 0.054 0.195 11.0 -0.202 7.0 18.0 BID -0.017 0.184 -9999.0 0.0 -0.666 34.0 34.0 MAP3K1 -0.002 0.027 -9999.0 0.0 -0.184 8.0 8.0 EIF2A 0.007 0.078 0.188 62.0 -0.203 10.0 72.0 TRADD 0.037 0.013 -9999.0 0.0 0.0 61.0 61.0 CRADD 0.04 0.006 -9999.0 0.0 0.0 10.0 10.0 MAPK3 -0.002 0.044 0.179 14.0 -0.203 7.0 21.0 response to heat 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 -0.007 0.048 0.18 13.0 -0.186 7.0 20.0 Cathepsin D/ceramide 0.028 0.032 -9999.0 0.0 -0.176 9.0 9.0 FADD -0.005 0.082 0.223 4.0 -0.254 28.0 32.0 KSR1 0.0 0.033 0.214 5.0 -0.184 8.0 13.0 MAPK8 0.002 0.053 -9999.0 0.0 -0.19 19.0 19.0 PRKRA 0.003 0.046 0.197 18.0 -0.178 9.0 27.0 PDGFA 0.037 0.013 -9999.0 0.0 0.0 57.0 57.0 TRAF2 0.039 0.01 -9999.0 0.0 0.0 32.0 32.0 IGF1 0.035 0.014 -9999.0 0.0 0.0 77.0 77.0 mol:GD3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ganglioside biosynthetic process 0.005 0.027 -9999.0 0.0 -0.18 9.0 9.0 CTSD 0.037 0.012 -9999.0 0.0 0.0 55.0 55.0 regulation of nitric oxide biosynthetic process 0.044 0.049 -9999.0 0.0 -0.134 34.0 34.0 response to radiation 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ERK1/PKC delta 0.029 0.057 0.209 11.0 -0.223 6.0 17.0 PRKCD 0.037 0.012 -9999.0 0.0 0.0 51.0 51.0 PRKCZ 0.039 0.009 -9999.0 0.0 0.0 27.0 27.0 mol:GW4869 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:sphingosine -0.015 0.009 0.0 151.0 -9999.0 0.0 151.0 RelA/NF kappa B1 0.044 0.049 -9999.0 0.0 -0.134 34.0 34.0 mol:glutathione -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PAWR 0.04 0.006 -9999.0 0.0 0.0 11.0 11.0 TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD 0.001 0.084 -9999.0 0.0 -0.254 30.0 30.0 TNFR1A/BAG4/TNF-alpha 0.06 0.045 -9999.0 0.0 -0.113 15.0 15.0 mol:Sphingosine-1-phosphate -0.018 0.007 0.0 74.0 -9999.0 0.0 74.0 MAP2K1 -0.008 0.041 0.174 15.0 -0.188 8.0 23.0 mol:C11AG 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.04 0.006 -9999.0 0.0 0.0 10.0 10.0 CYCS 0.003 0.047 0.127 2.0 -0.178 14.0 16.0 TNFRSF1A 0.036 0.014 -9999.0 0.0 0.0 72.0 72.0 NFKB1 0.036 0.013 -9999.0 0.0 0.0 66.0 66.0 TNFR1A/BAG4 0.045 0.037 -9999.0 0.0 -0.132 14.0 14.0 EIF2AK2 -0.003 0.055 0.182 24.0 -0.18 13.0 37.0 TNF-alpha/TNFR1A/FAN 0.059 0.052 -9999.0 0.0 -0.137 21.0 21.0 response to hydrogen peroxide -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP8 -0.005 0.137 -9999.0 0.0 -0.397 48.0 48.0 MAP2K2 -0.005 0.04 0.176 14.0 -0.188 7.0 21.0 SMPD3 -0.004 0.101 0.189 4.0 -0.294 47.0 51.0 TNF 0.04 0.008 -9999.0 0.0 0.0 22.0 22.0 PKC zeta/PAR4 0.057 0.017 -9999.0 0.0 -0.134 1.0 1.0 mol:PHOSPHOCHOLINE 0.004 0.031 0.148 2.0 -0.135 7.0 9.0 NF kappa B1/RelA/I kappa B alpha 0.079 0.081 -9999.0 0.0 -0.116 59.0 59.0 AIFM1 0.004 0.042 0.118 6.0 -0.173 14.0 20.0 BCL2 0.036 0.014 -9999.0 0.0 0.0 67.0 67.0