Caspase cascade in apoptosis Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TOP1 -0.011 0.138 0.28 2.0 -0.324 56.0 58.0 ACTA1 0.005 0.085 0.205 14.0 -0.237 19.0 33.0 NUMA1 -0.014 0.134 0.28 2.0 -0.31 62.0 64.0 SPTAN1 -0.002 0.083 0.206 8.0 -0.247 16.0 24.0 LIMK1 0.002 0.084 0.215 9.0 -0.247 16.0 25.0 BIRC3 0.025 0.02 -9999.0 0.0 0.0 210.0 210.0 BIRC2 0.036 0.014 -9999.0 0.0 0.0 72.0 72.0 BAX 0.039 0.008 -9999.0 0.0 0.0 23.0 23.0 CASP10 -0.011 0.025 0.059 54.0 -9999.0 0.0 54.0 CRMA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 XIAP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTK2 -0.031 0.168 0.28 2.0 -0.395 63.0 65.0 DIABLO 0.037 0.013 -9999.0 0.0 0.0 61.0 61.0 apoptotic nuclear changes -0.002 0.082 0.205 8.0 -0.243 16.0 24.0 response to UV 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRADD 0.04 0.006 -9999.0 0.0 0.0 10.0 10.0 GSN -0.002 0.083 0.198 12.0 -0.247 18.0 30.0 MADD 0.041 0.005 -9999.0 0.0 0.0 9.0 9.0 TFAP2A -0.028 0.197 -9999.0 0.0 -0.556 51.0 51.0 BID 0.002 0.022 -9999.0 0.0 -0.094 22.0 22.0 MAP3K1 -0.018 0.127 -9999.0 0.0 -0.367 57.0 57.0 TRADD 0.037 0.013 -9999.0 0.0 0.0 61.0 61.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 APAF-1/Pro-Caspase 9 0.051 0.039 -9999.0 0.0 -0.143 18.0 18.0 mol:Activated DNA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARHGDIB 0.007 0.104 0.231 39.0 -0.246 24.0 63.0 CASP9 0.039 0.008 -9999.0 0.0 0.0 24.0 24.0 DNA repair -0.012 0.08 0.272 23.0 -0.168 8.0 31.0 neuron apoptosis -0.03 0.193 -9999.0 0.0 -0.667 38.0 38.0 mol:NAD 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DNA fragmentation during apoptosis -0.013 0.118 0.249 4.0 -0.328 35.0 39.0 APAF1 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 CASP6 -0.094 0.326 -9999.0 0.0 -0.868 79.0 79.0 TRAF2 0.039 0.01 -9999.0 0.0 0.0 32.0 32.0 ICAD/CAD -0.002 0.079 0.211 8.0 -0.234 15.0 23.0 CASP7 0.016 0.097 0.2 29.0 -0.288 11.0 40.0 KRT18 -0.012 0.136 -9999.0 0.0 -0.572 22.0 22.0 apoptosis -0.036 0.158 0.299 10.0 -0.381 70.0 80.0 DFFA 0.002 0.081 0.204 9.0 -0.234 16.0 25.0 DFFB 0.002 0.082 0.2 11.0 -0.244 16.0 27.0 PARP1 0.012 0.08 0.168 8.0 -0.275 23.0 31.0 actin filament polymerization 0.003 0.081 0.251 13.0 -0.244 8.0 21.0 TNF 0.04 0.008 -9999.0 0.0 0.0 22.0 22.0 CYCS -0.001 0.067 0.153 9.0 -0.213 31.0 40.0 SATB1 -0.097 0.307 -9999.0 0.0 -0.824 79.0 79.0 SLK -0.001 0.085 0.232 8.0 -0.245 17.0 25.0 p15 BID/BAX 0.025 0.058 0.182 2.0 -0.149 28.0 30.0 CASP2 0.0 0.091 0.23 19.0 -0.241 35.0 54.0 JNK cascade 0.018 0.126 0.365 57.0 -9999.0 0.0 57.0 CASP3 0.007 0.087 0.192 18.0 -0.236 20.0 38.0 LMNB2 -0.047 0.207 0.233 3.0 -0.398 109.0 112.0 RIPK1 0.039 0.01 -9999.0 0.0 0.0 32.0 32.0 CASP4 0.033 0.016 -9999.0 0.0 0.0 107.0 107.0 Mammalian IAPs/DIABLO 0.011 0.088 -9999.0 0.0 -0.131 129.0 129.0 negative regulation of DNA binding -0.027 0.193 -9999.0 0.0 -0.548 51.0 51.0 stress fiber formation -0.001 0.084 0.231 8.0 -0.242 17.0 25.0 GZMB -0.016 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CASP1 -0.012 0.069 -9999.0 0.0 -0.197 66.0 66.0 LMNB1 -0.046 0.191 0.247 4.0 -0.352 114.0 118.0 APP -0.031 0.197 -9999.0 0.0 -0.687 37.0 37.0 TNFRSF1A 0.036 0.014 -9999.0 0.0 0.0 72.0 72.0 response to stress -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP8 -0.01 0.002 0.0 27.0 -9999.0 0.0 27.0 VIM -0.03 0.161 0.286 11.0 -0.383 71.0 82.0 LMNA -0.018 0.148 0.254 3.0 -0.351 67.0 70.0 TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD 0.002 0.086 -9999.0 0.0 -0.238 39.0 39.0 LRDD 0.039 0.01 -9999.0 0.0 0.0 36.0 36.0 SREBF1 0.002 0.082 0.202 10.0 -0.241 17.0 27.0 APAF-1/Caspase 9 0.027 0.156 -9999.0 0.0 -0.688 20.0 20.0 nuclear fragmentation during apoptosis -0.013 0.132 0.279 2.0 -0.306 62.0 64.0 CFL2 -0.003 0.081 0.245 8.0 -0.256 13.0 21.0 GAS2 0.004 0.086 0.222 14.0 -0.251 15.0 29.0 positive regulation of apoptosis -0.04 0.183 0.234 4.0 -0.398 87.0 91.0 PRF1 0.037 0.013 -9999.0 0.0 0.0 61.0 61.0