E-cadherin signaling in keratinocytes Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations keratinocyte differentiation -0.0 0.107 0.154 67.0 -0.303 34.0 101.0 adherens junction organization -0.017 0.125 0.202 6.0 -0.353 44.0 50.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.02 0.111 0.217 17.0 -0.282 27.0 44.0 FMN1 -0.012 0.111 0.156 5.0 -0.278 55.0 60.0 mol:IP3 0.009 0.096 0.157 69.0 -0.223 42.0 111.0 E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin -0.003 0.121 0.168 5.0 -0.289 59.0 64.0 CTNNB1 0.04 0.011 0.068 3.0 0.0 32.0 35.0 AKT1 -0.012 0.086 0.207 5.0 -0.267 35.0 40.0 E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin -0.002 0.143 -9999.0 0.0 -0.419 35.0 35.0 CTNND1 0.042 0.009 -9999.0 0.0 -0.002 18.0 18.0 mol:PI-4-5-P2 -0.005 0.115 0.23 17.0 -0.329 36.0 53.0 VASP -0.013 0.112 0.156 5.0 -0.286 54.0 59.0 ZYX -0.01 0.108 0.157 5.0 -0.303 44.0 49.0 JUB -0.015 0.115 0.163 1.0 -0.289 57.0 58.0 EGFR(dimer) 0.004 0.127 -9999.0 0.0 -0.321 46.0 46.0 E-cadherin/beta catenin-gamma catenin 0.052 0.058 -9999.0 0.0 -0.11 45.0 45.0 mol:PI-3-4-5-P3 0.001 0.098 -9999.0 0.0 -0.272 37.0 37.0 PIK3CA 0.029 0.02 -9999.0 0.0 -0.001 169.0 169.0 PI3K 0.001 0.1 -9999.0 0.0 -0.278 37.0 37.0 FYN -0.004 0.12 0.186 17.0 -0.276 58.0 75.0 mol:Ca2+ 0.009 0.095 0.156 69.0 -0.219 42.0 111.0 JUP 0.038 0.013 0.068 1.0 0.0 57.0 58.0 PIK3R1 0.035 0.017 -9999.0 0.0 -0.0 100.0 100.0 mol:DAG 0.009 0.096 0.157 69.0 -0.223 42.0 111.0 CDH1 0.036 0.015 -9999.0 0.0 0.0 79.0 79.0 RhoA/GDP 0.021 0.113 0.218 20.0 -0.28 28.0 48.0 establishment of polarity of embryonic epithelium -0.011 0.111 0.217 3.0 -0.319 41.0 44.0 SRC 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 RAC1 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 RHOA 0.04 0.006 -9999.0 0.0 0.0 13.0 13.0 EGFR 0.036 0.014 -9999.0 0.0 0.0 67.0 67.0 CASR 0.003 0.094 0.156 76.0 -0.267 26.0 102.0 RhoA/GTP 0.023 0.1 0.201 11.0 -0.261 27.0 38.0 AKT2 -0.013 0.085 0.196 3.0 -0.269 34.0 37.0 actin cable formation -0.016 0.11 0.248 7.0 -0.324 39.0 46.0 apoptosis -0.007 0.107 0.277 37.0 -0.167 71.0 108.0 CTNNA1 0.04 0.011 -9999.0 0.0 -0.001 32.0 32.0 mol:GDP 0.002 0.103 0.166 72.0 -0.278 30.0 102.0 PIP5K1A -0.013 0.108 0.154 4.0 -0.29 49.0 53.0 PLCG1 0.008 0.098 0.159 69.0 -0.227 42.0 111.0 Rac1/GTP 0.014 0.126 -9999.0 0.0 -0.309 43.0 43.0 homophilic cell adhesion 0.001 0.005 -9999.0 0.0 -9999.0 0.0 0.0