E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.032 0.138 -9999.0 0.0 -0.339 82.0 82.0 KLHL20 -0.015 0.102 0.207 12.0 -0.225 56.0 68.0 CYFIP2 0.038 0.011 -9999.0 0.0 0.0 45.0 45.0 Rac1/GDP -0.007 0.106 0.256 8.0 -0.246 45.0 53.0 ENAH -0.029 0.136 -9999.0 0.0 -0.338 79.0 79.0 AP1M1 0.036 0.014 -9999.0 0.0 0.0 72.0 72.0 RAP1B 0.037 0.012 -9999.0 0.0 0.0 54.0 54.0 RAP1A 0.039 0.01 -9999.0 0.0 0.0 35.0 35.0 CTNNB1 0.039 0.01 -9999.0 0.0 0.0 32.0 32.0 CDC42/GTP 0.005 0.077 0.158 2.0 -0.2 30.0 32.0 ABI1/Sra1/Nap1 -0.033 0.055 -9999.0 0.0 -0.153 69.0 69.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.068 0.067 -9999.0 0.0 -0.11 44.0 44.0 RAPGEF1 -0.027 0.124 0.269 4.0 -0.309 71.0 75.0 CTNND1 0.04 0.007 -9999.0 0.0 0.0 17.0 17.0 regulation of calcium-dependent cell-cell adhesion -0.019 0.145 -9999.0 0.0 -0.34 82.0 82.0 CRK -0.023 0.128 0.219 3.0 -0.333 67.0 70.0 E-cadherin/gamma catenin/alpha catenin 0.053 0.063 -9999.0 0.0 -0.137 41.0 41.0 alphaE/beta7 Integrin 0.048 0.038 -9999.0 0.0 -0.132 17.0 17.0 IQGAP1 0.036 0.013 -9999.0 0.0 0.0 66.0 66.0 NCKAP1 0.039 0.009 -9999.0 0.0 0.0 26.0 26.0 Rap1/GTP/I-afadin 0.043 0.063 -9999.0 0.0 -0.11 61.0 61.0 DLG1 -0.027 0.129 -9999.0 0.0 -0.348 66.0 66.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.028 0.044 -9999.0 0.0 -0.149 40.0 40.0 MLLT4 0.033 0.016 -9999.0 0.0 0.0 109.0 109.0 ARF6/GTP/NME1/Tiam1 0.047 0.062 -9999.0 0.0 -0.107 61.0 61.0 PI3K -0.034 0.058 -9999.0 0.0 -0.191 40.0 40.0 ARF6 0.04 0.007 -9999.0 0.0 0.0 16.0 16.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.04 0.051 -9999.0 0.0 -0.147 30.0 30.0 TIAM1 0.036 0.013 -9999.0 0.0 0.0 66.0 66.0 E-cadherin(dimer)/Ca2+ 0.065 0.069 -9999.0 0.0 -0.125 48.0 48.0 AKT1 0.009 0.076 0.166 59.0 -0.168 12.0 71.0 PIK3R1 0.034 0.016 -9999.0 0.0 0.0 99.0 99.0 CDH1 0.035 0.015 -9999.0 0.0 0.0 79.0 79.0 RhoA/GDP -0.009 0.106 0.253 4.0 -0.244 49.0 53.0 actin cytoskeleton organization -0.009 0.078 0.172 12.0 -0.166 53.0 65.0 CDC42/GDP -0.007 0.107 0.273 6.0 -0.249 45.0 51.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.001 0.075 -9999.0 0.0 -0.199 56.0 56.0 ITGB7 0.038 0.01 -9999.0 0.0 0.0 38.0 38.0 RAC1 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.07 0.074 -9999.0 0.0 -0.134 48.0 48.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.048 0.053 -9999.0 0.0 -0.105 45.0 45.0 mol:GDP -0.026 0.11 0.27 6.0 -0.278 48.0 54.0 CDC42/GTP/IQGAP1 0.039 0.046 -9999.0 0.0 -0.112 42.0 42.0 JUP 0.037 0.013 -9999.0 0.0 0.0 57.0 57.0 p120 catenin/RhoA/GDP 0.003 0.113 0.264 4.0 -0.257 45.0 49.0 RAC1/GTP/IQGAP1 0.039 0.045 -9999.0 0.0 -0.11 40.0 40.0 PIP5K1C/AP1M1 0.048 0.026 -9999.0 0.0 -0.134 1.0 1.0 RHOA 0.04 0.006 -9999.0 0.0 0.0 13.0 13.0 CDC42 0.04 0.007 -9999.0 0.0 0.0 18.0 18.0 CTNNA1 0.039 0.01 -9999.0 0.0 0.0 31.0 31.0 positive regulation of S phase of mitotic cell cycle -0.016 0.058 0.109 2.0 -0.118 103.0 105.0 NME1 0.036 0.014 -9999.0 0.0 0.0 71.0 71.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.03 0.138 -9999.0 0.0 -0.347 77.0 77.0 regulation of cell-cell adhesion -0.009 0.06 -9999.0 0.0 -0.154 47.0 47.0 WASF2 -0.007 0.043 0.106 14.0 -0.091 52.0 66.0 Rap1/GTP 0.004 0.084 0.217 5.0 -0.241 23.0 28.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.073 0.081 -9999.0 0.0 -0.121 51.0 51.0 CCND1 -0.02 0.071 0.142 1.0 -0.143 105.0 106.0 VAV2 -0.047 0.219 -9999.0 0.0 -0.598 56.0 56.0 RAP1/GDP 0.004 0.095 0.253 4.0 -0.264 25.0 29.0 adherens junction assembly -0.031 0.135 -9999.0 0.0 -0.335 80.0 80.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 PIP5K1C 0.037 0.012 -9999.0 0.0 0.0 51.0 51.0 regulation of heterotypic cell-cell adhesion 0.045 0.073 0.216 2.0 -0.123 60.0 62.0 E-cadherin/beta catenin 0.007 0.04 0.144 1.0 -0.228 12.0 13.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.031 0.135 -9999.0 0.0 -0.331 83.0 83.0 PIK3CA 0.029 0.019 -9999.0 0.0 0.0 166.0 166.0 Rac1/GTP -0.056 0.132 -9999.0 0.0 -0.351 66.0 66.0 E-cadherin/beta catenin/alpha catenin 0.055 0.062 -9999.0 0.0 -0.127 45.0 45.0 ITGAE 0.038 0.011 -9999.0 0.0 0.0 41.0 41.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.02 0.147 -9999.0 0.0 -0.347 82.0 82.0