Class I PI3K signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations ARF5/GTP -0.013 0.071 0.149 75.0 -0.178 5.0 80.0 DAPP1 -0.006 0.103 0.202 9.0 -0.263 39.0 48.0 Src family/SYK family/BLNK-LAT/BTK-ITK -0.015 0.143 -9999.0 0.0 -0.349 55.0 55.0 mol:DAG 0.002 0.075 0.172 21.0 -0.166 31.0 52.0 HRAS 0.04 0.013 0.074 4.0 -0.004 35.0 39.0 RAP1A 0.04 0.012 0.068 4.0 -0.001 36.0 40.0 ARF5/GDP 0.011 0.1 -9999.0 0.0 -0.245 40.0 40.0 PLCG2 0.035 0.015 -9999.0 0.0 0.0 82.0 82.0 PLCG1 0.038 0.011 -9999.0 0.0 0.0 43.0 43.0 ARF5 0.038 0.01 -9999.0 0.0 0.0 36.0 36.0 mol:GTP -0.014 0.064 0.137 71.0 -0.181 4.0 75.0 ARF1/GTP 0.001 0.063 0.137 80.0 -0.164 4.0 84.0 RHOA 0.04 0.006 -9999.0 0.0 0.0 13.0 13.0 YES1 0.037 0.012 -9999.0 0.0 0.0 51.0 51.0 RAP1A/GTP -0.006 0.074 0.164 77.0 -0.18 4.0 81.0 ADAP1 -0.015 0.059 0.127 68.0 -0.172 4.0 72.0 ARAP3 -0.014 0.064 0.135 71.0 -0.178 4.0 75.0 INPPL1 0.039 0.009 -9999.0 0.0 0.0 27.0 27.0 PREX1 0.038 0.012 -9999.0 0.0 0.0 48.0 48.0 ARHGEF6 0.036 0.013 -9999.0 0.0 0.0 64.0 64.0 ARHGEF7 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 ARF1 0.038 0.011 -9999.0 0.0 0.0 45.0 45.0 NRAS 0.041 0.011 0.069 3.0 0.0 30.0 33.0 FYN 0.034 0.016 -9999.0 0.0 0.0 94.0 94.0 ARF6 0.04 0.007 -9999.0 0.0 0.0 16.0 16.0 FGR 0.04 0.007 -9999.0 0.0 0.0 15.0 15.0 mol:Ca2+ -0.001 0.049 0.178 13.0 -0.118 6.0 19.0 mol:IP4 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.036 0.013 -9999.0 0.0 0.0 66.0 66.0 ZAP70 0.041 0.005 -9999.0 0.0 0.0 9.0 9.0 mol:IP3 -0.004 0.062 0.213 13.0 -0.156 11.0 24.0 LYN 0.035 0.015 -9999.0 0.0 0.0 83.0 83.0 ARF1/GDP 0.014 0.097 -9999.0 0.0 -0.247 36.0 36.0 RhoA/GDP 0.032 0.084 0.188 46.0 -0.173 21.0 67.0 PDK1/Src/Hsp90 0.049 0.023 -9999.0 0.0 -0.109 6.0 6.0 BLNK 0.037 0.013 -9999.0 0.0 0.0 62.0 62.0 actin cytoskeleton reorganization 0.002 0.094 0.222 9.0 -0.267 22.0 31.0 SRC 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 PLEKHA2 -0.014 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 PTEN 0.032 0.026 -9999.0 0.0 -0.03 71.0 71.0 HSP90AA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.013 0.073 0.151 77.0 -0.177 4.0 81.0 RhoA/GTP -0.01 0.077 0.158 81.0 -0.177 5.0 86.0 Src family/SYK family/BLNK-LAT -0.003 0.097 -9999.0 0.0 -0.272 37.0 37.0 BLK 0.033 0.017 -9999.0 0.0 0.0 114.0 114.0 PDPK1 0.039 0.009 -9999.0 0.0 0.0 29.0 29.0 CYTH1 -0.015 0.059 0.127 68.0 -0.172 4.0 72.0 HCK 0.036 0.013 -9999.0 0.0 0.0 65.0 65.0 CYTH3 -0.015 0.059 0.127 68.0 -0.172 4.0 72.0 CYTH2 -0.015 0.059 0.127 68.0 -0.172 4.0 72.0 KRAS 0.034 0.017 0.09 1.0 -0.001 98.0 99.0 GO:0030676 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FOXO3 0.008 0.047 0.158 2.0 -0.159 15.0 17.0 SGK1 0.008 0.046 -9999.0 0.0 -0.168 15.0 15.0 INPP5D -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.005 0.095 -9999.0 0.0 -0.256 40.0 40.0 SOS1 0.037 0.012 -9999.0 0.0 0.0 51.0 51.0 SYK 0.036 0.014 -9999.0 0.0 0.0 67.0 67.0 ARF6/GDP -0.003 0.079 0.164 58.0 -0.177 18.0 76.0 mol:PI-3-4-5-P3 -0.015 0.063 0.136 68.0 -0.18 4.0 72.0 ARAP3/RAP1A/GTP -0.006 0.074 0.164 77.0 -0.181 4.0 81.0 VAV1 0.036 0.014 -9999.0 0.0 0.0 69.0 69.0 mol:PI-3-4-P2 -0.01 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP/PI3K Class I 0.042 0.063 0.222 23.0 -0.118 38.0 61.0 PLEKHA1 -0.015 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.014 0.101 -9999.0 0.0 -0.249 40.0 40.0 LAT 0.04 0.006 -9999.0 0.0 0.0 11.0 11.0 Rac1/GTP -0.006 0.099 -9999.0 0.0 -0.263 50.0 50.0 ITK -0.014 0.064 0.132 73.0 -0.177 5.0 78.0 Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma -0.003 0.093 0.203 16.0 -0.223 34.0 50.0 LCK 0.039 0.009 -9999.0 0.0 0.0 25.0 25.0 BTK -0.016 0.067 0.135 70.0 -0.185 9.0 79.0