Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.066 0.175 -9999.0 0.0 -0.39 122.0 122.0 IHH 0.021 0.066 -9999.0 0.0 -0.098 126.0 126.0 SHH Np/Cholesterol/GAS1 0.027 0.025 -9999.0 0.0 -0.103 12.0 12.0 LRPAP1 0.036 0.014 -9999.0 0.0 0.0 72.0 72.0 dorsoventral neural tube patterning -0.027 0.025 0.103 12.0 -9999.0 0.0 12.0 SMO/beta Arrestin2 0.015 0.118 0.241 2.0 -0.203 97.0 99.0 SMO -0.004 0.109 -9999.0 0.0 -0.205 108.0 108.0 AKT1 -0.015 0.132 -9999.0 0.0 -0.398 35.0 35.0 ARRB2 0.038 0.011 -9999.0 0.0 0.0 46.0 46.0 BOC 0.035 0.015 -9999.0 0.0 0.0 82.0 82.0 ADRBK1 0.041 0.004 -9999.0 0.0 0.0 6.0 6.0 heart looping -0.003 0.108 -9999.0 0.0 -0.203 108.0 108.0 STIL -0.002 0.096 0.208 26.0 -0.171 104.0 130.0 DHH N/PTCH2 0.058 0.014 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.002 0.107 -9999.0 0.0 -0.189 125.0 125.0 PIK3CA 0.029 0.019 -9999.0 0.0 0.0 166.0 166.0 DHH 0.04 0.006 -9999.0 0.0 0.0 11.0 11.0 PTHLH -0.057 0.159 -9999.0 0.0 -0.376 108.0 108.0 determination of left/right symmetry -0.003 0.108 -9999.0 0.0 -0.203 108.0 108.0 PIK3R1 0.034 0.016 -9999.0 0.0 0.0 99.0 99.0 skeletal system development -0.056 0.159 -9999.0 0.0 -0.373 108.0 108.0 IHH N/Hhip 0.034 0.054 -9999.0 0.0 -0.104 2.0 2.0 DHH N/Hhip 0.055 0.02 -9999.0 0.0 -0.134 1.0 1.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.003 0.108 -9999.0 0.0 -0.203 108.0 108.0 pancreas development 0.038 0.011 -9999.0 0.0 0.0 44.0 44.0 HHAT 0.039 0.009 -9999.0 0.0 0.0 25.0 25.0 PI3K 0.023 0.06 -9999.0 0.0 -0.15 44.0 44.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.036 0.013 -9999.0 0.0 0.0 66.0 66.0 somite specification -0.003 0.108 -9999.0 0.0 -0.203 108.0 108.0 SHH Np/Cholesterol/PTCH1 -0.007 0.085 -9999.0 0.0 -0.17 109.0 109.0 SHH Np/Cholesterol/PTCH2 0.032 0.015 -9999.0 0.0 -0.103 1.0 1.0 SHH Np/Cholesterol/Megalin 0.021 0.028 -9999.0 0.0 -0.103 15.0 15.0 SHH -0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.037 0.095 -9999.0 0.0 -0.209 126.0 126.0 SMO/Vitamin D3 -0.007 0.1 0.195 17.0 -0.197 106.0 123.0 SHH Np/Cholesterol/Hhip 0.031 0.017 -9999.0 0.0 -0.103 2.0 2.0 LRP2 0.029 0.019 -9999.0 0.0 0.0 160.0 160.0 receptor-mediated endocytosis -0.0 0.1 0.193 18.0 -0.197 66.0 84.0 SHH Np/Cholesterol/BOC 0.026 0.027 -9999.0 0.0 -0.102 16.0 16.0 SHH Np/Cholesterol/CDO 0.023 0.033 -9999.0 0.0 -0.103 27.0 27.0 mesenchymal cell differentiation -0.03 0.017 0.103 2.0 -9999.0 0.0 2.0 mol:Vitamin D3 -0.015 0.086 0.198 20.0 -0.171 108.0 128.0 IHH N/PTCH2 0.037 0.054 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.034 0.015 -9999.0 0.0 0.0 91.0 91.0 IHH N/PTCH1 -0.021 0.106 -9999.0 0.0 -0.21 126.0 126.0 Megalin/LRPAP1 0.027 0.054 -9999.0 0.0 -0.136 40.0 40.0 PTCH2 0.04 0.008 -9999.0 0.0 0.0 19.0 19.0 SHH Np/Cholesterol 0.031 0.041 0.196 31.0 -0.097 1.0 32.0 PTCH1 -0.037 0.096 -9999.0 0.0 -0.21 126.0 126.0 HHIP 0.038 0.011 -9999.0 0.0 0.0 44.0 44.0