Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.005 0.067 -9999.0 0.0 -0.193 48.0 48.0 epithelial cell differentiation 0.058 0.066 -9999.0 0.0 -0.124 48.0 48.0 CYFIP2 0.038 0.011 -9999.0 0.0 0.0 45.0 45.0 ENAH -0.036 0.067 0.186 12.0 -0.198 7.0 19.0 EGFR 0.036 0.014 -9999.0 0.0 0.0 67.0 67.0 EPHA2 0.039 0.009 -9999.0 0.0 0.0 26.0 26.0 MYO6 -0.029 0.048 0.178 9.0 -0.201 16.0 25.0 CTNNB1 0.039 0.01 -9999.0 0.0 0.0 32.0 32.0 ABI1/Sra1/Nap1 0.061 0.057 -9999.0 0.0 -0.123 39.0 39.0 AQP5 -0.069 0.135 0.161 1.0 -0.366 88.0 89.0 CTNND1 0.04 0.007 -9999.0 0.0 0.0 17.0 17.0 mol:PI-4-5-P2 -0.029 0.044 0.175 9.0 -0.189 12.0 21.0 regulation of calcium-dependent cell-cell adhesion -0.029 0.041 0.174 6.0 -0.189 12.0 18.0 EGF 0.038 0.01 -9999.0 0.0 0.0 38.0 38.0 NCKAP1 0.039 0.009 -9999.0 0.0 0.0 26.0 26.0 AQP3 -0.018 0.048 0.166 2.0 -0.283 8.0 10.0 cortical microtubule organization 0.058 0.066 -9999.0 0.0 -0.124 48.0 48.0 GO:0000145 -0.028 0.04 0.155 9.0 -0.181 12.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.065 0.069 -9999.0 0.0 -0.125 48.0 48.0 MLLT4 0.033 0.016 -9999.0 0.0 0.0 109.0 109.0 ARF6/GDP -0.052 0.047 -9999.0 0.0 -0.194 26.0 26.0 ARF6 0.04 0.007 -9999.0 0.0 0.0 16.0 16.0 Ephrin A1/EPHA2/NCK1/GIT1 0.06 0.078 -9999.0 0.0 -0.121 66.0 66.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.015 0.046 0.167 7.0 -0.192 15.0 22.0 PVRL2 0.037 0.012 -9999.0 0.0 0.0 51.0 51.0 ZYX -0.026 0.042 0.178 9.0 -0.192 8.0 17.0 ARF6/GTP 0.065 0.084 -9999.0 0.0 -0.121 68.0 68.0 CDH1 0.035 0.014 -9999.0 0.0 0.0 79.0 79.0 EGFR/EGFR/EGF/EGF 0.039 0.073 -9999.0 0.0 -0.125 67.0 67.0 RhoA/GDP 0.058 0.068 -9999.0 0.0 -0.123 50.0 50.0 actin cytoskeleton organization -0.031 0.048 0.156 9.0 -0.213 17.0 26.0 IGF-1R heterotetramer 0.033 0.017 -9999.0 0.0 0.0 112.0 112.0 GIT1 0.039 0.009 -9999.0 0.0 0.0 25.0 25.0 IGF1R 0.033 0.017 -9999.0 0.0 0.0 112.0 112.0 IGF1 0.035 0.014 -9999.0 0.0 0.0 77.0 77.0 DIAPH1 -0.003 0.22 -9999.0 0.0 -0.568 63.0 63.0 Wnt receptor signaling pathway -0.058 0.066 0.124 48.0 -9999.0 0.0 48.0 RHOA 0.04 0.006 -9999.0 0.0 0.0 13.0 13.0 RhoA/GTP -0.051 0.046 -9999.0 0.0 -0.19 26.0 26.0 CTNNA1 0.039 0.01 -9999.0 0.0 0.0 31.0 31.0 VCL -0.031 0.049 0.157 9.0 -0.218 17.0 26.0 EFNA1 0.034 0.016 -9999.0 0.0 0.0 96.0 96.0 LPP -0.029 0.044 0.163 8.0 -0.194 13.0 21.0 Ephrin A1/EPHA2 0.035 0.075 -9999.0 0.0 -0.123 77.0 77.0 SEC6/SEC8 -0.04 0.041 -9999.0 0.0 -0.186 17.0 17.0 MGAT3 -0.029 0.042 0.176 6.0 -0.192 12.0 18.0 HGF/MET 0.019 0.084 -9999.0 0.0 -0.125 110.0 110.0 HGF 0.039 0.009 -9999.0 0.0 0.0 27.0 27.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.005 0.068 -9999.0 0.0 -0.194 48.0 48.0 actin cable formation 0.0 0.094 0.246 23.0 -0.232 21.0 44.0 KIAA1543 -0.033 0.042 0.161 8.0 -0.195 12.0 20.0 KIFC3 -0.031 0.044 0.176 9.0 -0.192 12.0 21.0 NCK1 0.036 0.014 -9999.0 0.0 0.0 70.0 70.0 EXOC3 0.037 0.012 -9999.0 0.0 0.0 55.0 55.0 ACTN1 -0.03 0.048 0.178 10.0 -0.199 15.0 25.0 NCK1/GIT1 0.043 0.047 -9999.0 0.0 -0.133 31.0 31.0 mol:GDP 0.058 0.066 -9999.0 0.0 -0.124 48.0 48.0 EXOC4 0.038 0.011 -9999.0 0.0 0.0 41.0 41.0 STX4 -0.029 0.032 0.038 7.0 -0.12 46.0 53.0 PIP5K1C -0.029 0.044 0.176 9.0 -0.192 12.0 21.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 ROCK1 -0.03 0.08 0.219 13.0 -0.229 6.0 19.0 adherens junction assembly -0.043 0.12 -9999.0 0.0 -0.384 36.0 36.0 IGF-1R heterotetramer/IGF1 0.025 0.08 -9999.0 0.0 -0.124 95.0 95.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.047 -9999.0 0.0 -0.137 27.0 27.0 MET 0.027 0.02 -9999.0 0.0 0.0 191.0 191.0 PLEKHA7 -0.03 0.046 0.178 10.0 -0.196 13.0 23.0 mol:GTP 0.057 0.076 -9999.0 0.0 -0.121 66.0 66.0 establishment of epithelial cell apical/basal polarity -0.02 0.074 0.146 66.0 -0.198 13.0 79.0 cortical actin cytoskeleton stabilization 0.005 0.067 -9999.0 0.0 -0.193 48.0 48.0 regulation of cell-cell adhesion -0.031 0.048 0.156 9.0 -0.213 17.0 26.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.005 0.068 -9999.0 0.0 -0.194 48.0 48.0