IL2 signaling events mediated by PI3K Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.012 0.165 -9999.0 0.0 -0.683 19.0 19.0 UGCG -0.003 0.133 -9999.0 0.0 -0.667 18.0 18.0 AKT1/mTOR/p70S6K/Hsp90/TERT -0.021 0.177 0.266 2.0 -0.383 76.0 78.0 mol:GTP -0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:glucosylceramide -0.002 0.131 -9999.0 0.0 -0.657 18.0 18.0 mol:DAG -0.008 0.028 0.169 12.0 -9999.0 0.0 12.0 CaM/Ca2+/Calcineurin A alpha-beta B1 -0.036 0.224 0.285 1.0 -0.473 84.0 85.0 FRAP1 -0.055 0.259 0.293 2.0 -0.562 83.0 85.0 FOXO3 -0.052 0.251 0.279 1.0 -0.522 91.0 92.0 AKT1 -0.06 0.276 0.29 1.0 -0.574 91.0 92.0 GAB2 0.029 0.02 -9999.0 0.0 -0.003 149.0 149.0 SMPD1 0.002 0.115 -9999.0 0.0 -0.614 16.0 16.0 SGMS1 -0.003 0.038 0.059 12.0 -0.076 81.0 93.0 positive regulation of NF-kappaB transcription factor activity -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.019 0.034 0.027 1.0 -0.114 51.0 52.0 CALM1 0.039 0.009 -9999.0 0.0 0.0 26.0 26.0 cell proliferation 0.005 0.163 0.222 21.0 -0.3 77.0 98.0 EIF3A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.02 0.062 -9999.0 0.0 -0.138 52.0 52.0 RPS6KB1 -0.022 0.2 -9999.0 0.0 -0.877 25.0 25.0 mol:sphingomyelin -0.008 0.028 0.169 12.0 -9999.0 0.0 12.0 natural killer cell activation -0.001 0.004 -9999.0 0.0 -0.015 17.0 17.0 JAK3 0.034 0.022 -9999.0 0.0 -0.046 24.0 24.0 PIK3R1 0.031 0.024 -9999.0 0.0 -0.041 26.0 26.0 JAK1 0.036 0.021 -9999.0 0.0 -0.018 57.0 57.0 NFKB1 0.036 0.013 -9999.0 0.0 0.0 66.0 66.0 MYC -0.035 0.34 0.384 10.0 -0.811 75.0 85.0 MYB -0.047 0.294 -9999.0 0.0 -1.091 39.0 39.0 IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K -0.024 0.173 0.267 2.0 -0.352 89.0 91.0 40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 -0.004 0.19 -9999.0 0.0 -0.811 25.0 25.0 mol:PI-3-4-5-P3 -0.024 0.17 0.266 2.0 -0.343 90.0 92.0 Rac1/GDP 0.008 0.044 -9999.0 0.0 -0.104 50.0 50.0 T cell proliferation -0.027 0.162 0.278 6.0 -0.337 83.0 89.0 SHC1 0.037 0.016 -9999.0 0.0 -0.015 43.0 43.0 RAC1 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 positive regulation of cyclin-dependent protein kinase activity 0.001 0.019 0.031 39.0 -0.064 39.0 78.0 PRKCZ -0.027 0.165 0.281 6.0 -0.348 83.0 89.0 NF kappa B1 p50/RelA -0.026 0.236 0.311 1.0 -0.486 82.0 83.0 IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K -0.005 0.121 -9999.0 0.0 -0.322 44.0 44.0 HSP90AA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.04 0.006 -9999.0 0.0 0.0 10.0 10.0 IL2RA 0.036 0.017 -9999.0 0.0 -0.011 58.0 58.0 IL2RB 0.033 0.022 -9999.0 0.0 -0.01 96.0 96.0 TERT 0.037 0.012 -9999.0 0.0 0.0 53.0 53.0 E2F1 -0.006 0.124 -9999.0 0.0 -0.413 40.0 40.0 SOS1 0.035 0.018 -9999.0 0.0 -0.009 71.0 71.0 RPS6 0.039 0.01 -9999.0 0.0 0.0 32.0 32.0 mol:cAMP -0.001 0.009 0.031 36.0 -0.017 38.0 74.0 PTPN11 0.035 0.02 -9999.0 0.0 -0.018 64.0 64.0 IL2RG 0.025 0.026 -9999.0 0.0 -0.041 28.0 28.0 actin cytoskeleton organization -0.027 0.162 0.278 6.0 -0.337 83.0 89.0 GRB2 0.037 0.016 -9999.0 0.0 -0.015 41.0 41.0 IL2 0.035 0.024 -9999.0 0.0 -0.04 38.0 38.0 PIK3CA 0.027 0.024 -9999.0 0.0 -0.042 21.0 21.0 Rac1/GTP 0.029 0.061 -9999.0 0.0 -0.103 45.0 45.0 LCK 0.035 0.024 -9999.0 0.0 -0.039 41.0 41.0 BCL2 -0.029 0.198 0.375 1.0 -0.529 48.0 49.0