Plasma membrane estrogen receptor signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations GNB1/GNG2 0.064 0.064 -9999.0 0.0 -0.104 50.0 50.0 ER alpha/Gai/GDP/Gbeta gamma -0.024 0.14 -9999.0 0.0 -0.307 73.0 73.0 AKT1 -0.086 0.263 -9999.0 0.0 -0.646 91.0 91.0 PIK3CA 0.029 0.019 -9999.0 0.0 0.0 166.0 166.0 E2/ER alpha (dimer)/PELP1/Src/PI3K -0.085 0.269 -9999.0 0.0 -0.654 92.0 92.0 mol:Ca2+ -0.001 0.071 0.183 10.0 -0.277 25.0 35.0 IGF1R 0.033 0.017 -9999.0 0.0 0.0 112.0 112.0 E2/ER alpha (dimer)/Striatin 0.034 0.05 -9999.0 0.0 -0.112 51.0 51.0 SHC1 0.039 0.008 -9999.0 0.0 0.0 23.0 23.0 apoptosis 0.083 0.251 0.618 91.0 -9999.0 0.0 91.0 RhoA/GTP 0.014 0.047 -9999.0 0.0 -0.108 57.0 57.0 E2/ER alpha (dimer)/PELP1/Src/p130 Cas -0.009 0.141 0.274 1.0 -0.296 68.0 69.0 regulation of stress fiber formation 0.015 0.069 0.158 16.0 -0.148 60.0 76.0 E2/ERA-ERB (dimer) 0.037 0.045 -9999.0 0.0 -0.109 42.0 42.0 KRAS 0.034 0.016 -9999.0 0.0 0.0 95.0 95.0 G13/GTP 0.033 0.045 -9999.0 0.0 -0.098 49.0 49.0 pseudopodium formation -0.015 0.069 0.148 60.0 -0.158 16.0 76.0 E2/ER alpha (dimer)/PELP1 0.035 0.046 -9999.0 0.0 -0.108 42.0 42.0 GRB2 0.04 0.008 -9999.0 0.0 0.0 21.0 21.0 GNG2 0.039 0.009 -9999.0 0.0 0.0 29.0 29.0 GNAO1 0.035 0.015 -9999.0 0.0 0.0 85.0 85.0 HRAS 0.039 0.01 -9999.0 0.0 0.0 31.0 31.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:NO -0.038 0.162 -9999.0 0.0 -0.39 74.0 74.0 E2/ER beta (dimer) 0.03 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.002 0.075 0.142 2.0 -0.229 46.0 48.0 mol:NADP -0.038 0.162 -9999.0 0.0 -0.39 74.0 74.0 PIK3R1 0.034 0.016 -9999.0 0.0 0.0 99.0 99.0 mol:IP3 -0.003 0.071 0.183 7.0 -0.287 25.0 32.0 IGF-1R heterotetramer 0.033 0.017 -9999.0 0.0 0.0 112.0 112.0 PLCB1 0.004 0.068 -9999.0 0.0 -0.292 23.0 23.0 PLCB2 0.005 0.067 -9999.0 0.0 -0.277 25.0 25.0 IGF1 0.035 0.014 -9999.0 0.0 0.0 77.0 77.0 mol:L-citrulline -0.038 0.162 -9999.0 0.0 -0.39 74.0 74.0 RHOA 0.04 0.006 -9999.0 0.0 0.0 13.0 13.0 Gai/GDP -0.007 0.179 -9999.0 0.0 -0.591 44.0 44.0 JNK cascade 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BCAR1 0.036 0.013 -9999.0 0.0 0.0 65.0 65.0 ESR2 0.04 0.007 -9999.0 0.0 0.0 15.0 15.0 GNAQ 0.038 0.012 -9999.0 0.0 0.0 48.0 48.0 ESR1 0.034 0.015 -9999.0 0.0 0.0 91.0 91.0 Gq family/GDP/Gbeta gamma -0.048 0.243 -9999.0 0.0 -0.662 67.0 67.0 E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 0.018 0.116 -9999.0 0.0 -0.665 11.0 11.0 E2/ER alpha (dimer)/PELP1/Src/p52 SHC -0.008 0.142 0.255 2.0 -0.296 69.0 71.0 GNAZ 0.038 0.011 -9999.0 0.0 0.0 46.0 46.0 E2/ER alpha (dimer) 0.016 0.041 -9999.0 0.0 -0.125 42.0 42.0 STRN 0.039 0.008 -9999.0 0.0 0.0 23.0 23.0 GNAL 0.04 0.008 -9999.0 0.0 0.0 22.0 22.0 PELP1 0.038 0.011 -9999.0 0.0 0.0 39.0 39.0 MAPK11 0.013 0.008 0.069 1.0 -9999.0 0.0 1.0 GNAI2 0.04 0.006 -9999.0 0.0 0.0 13.0 13.0 GNAI3 0.038 0.011 -9999.0 0.0 0.0 45.0 45.0 GNAI1 0.034 0.015 -9999.0 0.0 0.0 93.0 93.0 HBEGF -0.018 0.149 0.323 15.0 -0.332 57.0 72.0 cAMP biosynthetic process 0.031 0.038 -9999.0 0.0 -0.09 40.0 40.0 SRC -0.024 0.139 0.222 17.0 -0.311 65.0 82.0 PI3K 0.023 0.06 -9999.0 0.0 -0.15 44.0 44.0 GNB1 0.039 0.01 -9999.0 0.0 0.0 33.0 33.0 G13/GDP/Gbeta gamma 0.04 0.091 -9999.0 0.0 -0.202 47.0 47.0 SOS1 0.037 0.012 -9999.0 0.0 0.0 51.0 51.0 IGF-1R heterotetramer/IGF1 -0.037 0.103 -9999.0 0.0 -0.248 73.0 73.0 Gs family/GTP 0.041 0.043 -9999.0 0.0 -0.091 40.0 40.0 EntrezGene:2778 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP 0.054 0.049 -9999.0 0.0 -0.106 27.0 27.0 vasodilation -0.035 0.155 -9999.0 0.0 -0.374 74.0 74.0 mol:DAG -0.003 0.071 0.183 7.0 -0.287 25.0 32.0 Gs family/GDP/Gbeta gamma 0.005 0.078 -9999.0 0.0 -0.208 45.0 45.0 MSN -0.016 0.072 0.152 60.0 -0.168 16.0 76.0 Gq family/GTP 0.018 0.072 -9999.0 0.0 -0.282 25.0 25.0 mol:PI-3-4-5-P3 -0.081 0.259 -9999.0 0.0 -0.622 95.0 95.0 NRAS 0.039 0.009 -9999.0 0.0 0.0 30.0 30.0 mol:E2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell adhesion 0.035 0.155 0.374 74.0 -9999.0 0.0 74.0 GRB2/SOS1 0.047 0.044 -9999.0 0.0 -0.142 24.0 24.0 RhoA/GDP 0.016 0.086 -9999.0 0.0 -0.218 49.0 49.0 NOS3 -0.04 0.169 -9999.0 0.0 -0.409 74.0 74.0 GNA11 0.037 0.013 -9999.0 0.0 0.0 61.0 61.0 MAPKKK cascade -0.03 0.185 -9999.0 0.0 -0.467 73.0 73.0 E2/ER alpha (dimer)/PELP1/Src -0.014 0.143 0.231 15.0 -0.303 71.0 86.0 ruffle organization -0.015 0.069 0.148 60.0 -0.158 16.0 76.0 ROCK2 -0.009 0.079 0.172 67.0 -0.168 7.0 74.0 GNA14 0.039 0.009 -9999.0 0.0 0.0 29.0 29.0 GNA15 0.036 0.014 -9999.0 0.0 0.0 68.0 68.0 GNA13 0.039 0.008 -9999.0 0.0 0.0 23.0 23.0 MMP9 -0.02 0.149 0.308 22.0 -0.313 65.0 87.0 MMP2 -0.021 0.136 0.228 13.0 -0.326 56.0 69.0