Signaling events mediated by PTP1B Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PDGFRB 0.036 0.013 -9999.0 0.0 0.0 65.0 65.0 Jak2/Leptin Receptor -0.019 0.149 0.253 1.0 -0.402 52.0 53.0 PTP1B/AKT1 -0.034 0.114 -9999.0 0.0 -0.243 79.0 79.0 FYN 0.034 0.016 -9999.0 0.0 0.0 94.0 94.0 p210 bcr-abl/PTP1B -0.052 0.114 -9999.0 0.0 -0.258 88.0 88.0 EGFR 0.036 0.017 -9999.0 0.0 -0.004 76.0 76.0 EGF/EGFR -0.025 0.12 -9999.0 0.0 -0.238 84.0 84.0 CSF1 0.035 0.015 -9999.0 0.0 0.0 84.0 84.0 AKT1 0.039 0.01 -9999.0 0.0 0.0 34.0 34.0 INSR 0.038 0.012 -9999.0 0.0 0.0 49.0 49.0 PTP1B/N-cadherin -0.054 0.119 -9999.0 0.0 -0.243 119.0 119.0 Insulin Receptor/Insulin -0.008 0.115 -9999.0 0.0 -0.229 55.0 55.0 HCK 0.036 0.013 -9999.0 0.0 0.0 65.0 65.0 CRK 0.038 0.012 -9999.0 0.0 0.0 49.0 49.0 TYK2 -0.037 0.119 0.234 24.0 -0.261 69.0 93.0 EGF 0.037 0.016 -9999.0 0.0 -0.009 52.0 52.0 YES1 0.037 0.012 -9999.0 0.0 0.0 51.0 51.0 CAV1 -0.036 0.106 0.186 1.0 -0.247 73.0 74.0 TXN 0.037 0.012 -9999.0 0.0 0.0 49.0 49.0 PTP1B/IRS1/GRB2 -0.027 0.129 -9999.0 0.0 -0.249 87.0 87.0 cell migration 0.052 0.114 0.258 88.0 -9999.0 0.0 88.0 STAT3 0.038 0.011 -9999.0 0.0 0.0 41.0 41.0 PRLR 0.038 0.016 -9999.0 0.0 -9999.0 0.0 0.0 ITGA2B 0.039 0.008 -9999.0 0.0 0.0 22.0 22.0 CSF1R 0.034 0.016 -9999.0 0.0 0.0 94.0 94.0 Prolactin Receptor/Prolactin 0.056 0.028 -9999.0 0.0 -9999.0 0.0 0.0 FGR 0.04 0.007 -9999.0 0.0 0.0 15.0 15.0 PTP1B/p130 Cas -0.035 0.118 -9999.0 0.0 -0.249 86.0 86.0 Crk/p130 Cas -0.028 0.125 -9999.0 0.0 -0.253 78.0 78.0 DOK1 -0.038 0.108 0.208 2.0 -0.251 67.0 69.0 JAK2 -0.031 0.145 -9999.0 0.0 -0.42 52.0 52.0 Jak2/Leptin Receptor/Leptin -0.026 0.144 -9999.0 0.0 -0.301 60.0 60.0 PIK3R1 0.034 0.016 -9999.0 0.0 0.0 99.0 99.0 PTPN1 -0.053 0.114 -9999.0 0.0 -0.261 88.0 88.0 LYN 0.035 0.015 -9999.0 0.0 0.0 83.0 83.0 CDH2 0.019 0.021 -9999.0 0.0 0.0 290.0 290.0 SRC 0.003 0.101 -9999.0 0.0 -0.497 17.0 17.0 ITGB3 0.032 0.017 -9999.0 0.0 0.0 116.0 116.0 CAT1/PTP1B -0.041 0.131 0.221 7.0 -0.289 76.0 83.0 CAPN1 0.038 0.009 -9999.0 0.0 0.0 25.0 25.0 CSK 0.039 0.009 -9999.0 0.0 0.0 25.0 25.0 PI3K -0.012 0.107 -9999.0 0.0 -0.236 43.0 43.0 mol:H2O2 0.002 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 (dimer) -0.022 0.137 -9999.0 0.0 -0.281 60.0 60.0 negative regulation of transcription -0.03 0.144 -9999.0 0.0 -0.415 52.0 52.0 FCGR2A 0.032 0.017 -9999.0 0.0 0.0 119.0 119.0 FER 0.037 0.011 -9999.0 0.0 0.0 44.0 44.0 alphaIIb/beta3 Integrin 0.037 0.05 -9999.0 0.0 -0.137 35.0 35.0 BLK 0.033 0.017 -9999.0 0.0 0.0 114.0 114.0 Insulin Receptor/Insulin/Shc 0.068 0.036 -9999.0 0.0 -0.12 5.0 5.0 RHOA 0.039 0.006 -9999.0 0.0 0.0 13.0 13.0 LEPR 0.039 0.011 -9999.0 0.0 0.0 40.0 40.0 BCAR1 0.036 0.013 -9999.0 0.0 0.0 65.0 65.0 p210 bcr-abl/Grb2 0.04 0.008 -9999.0 0.0 0.0 21.0 21.0 mol:NADPH -0.001 0.002 -9999.0 0.0 -9999.0 0.0 0.0 TRPV6 -0.011 0.123 0.22 1.0 -0.296 49.0 50.0 PRL 0.042 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SOCS3 -0.029 0.268 -9999.0 0.0 -1.174 28.0 28.0 SPRY2 0.023 0.021 -9999.0 0.0 0.0 240.0 240.0 Insulin Receptor/Insulin/IRS1 0.068 0.038 -9999.0 0.0 -0.119 8.0 8.0 CSF1/CSF1R -0.043 0.135 -9999.0 0.0 -0.266 96.0 96.0 Ras protein signal transduction 0.011 0.091 0.599 11.0 -9999.0 0.0 11.0 IRS1 0.04 0.008 -9999.0 0.0 0.0 22.0 22.0 INS 0.039 0.01 -9999.0 0.0 0.0 30.0 30.0 LEP 0.039 0.008 -9999.0 0.0 0.0 22.0 22.0 STAT5B -0.041 0.126 -9999.0 0.0 -0.282 75.0 75.0 STAT5A -0.043 0.128 -9999.0 0.0 -0.287 76.0 76.0 GRB2 0.04 0.008 -9999.0 0.0 0.0 21.0 21.0 PDGFB-D/PDGFRB -0.042 0.118 -9999.0 0.0 -0.249 90.0 90.0 CSN2 0.039 0.06 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.029 0.019 -9999.0 0.0 0.0 166.0 166.0 LAT -0.059 0.191 -9999.0 0.0 -0.481 85.0 85.0 YBX1 0.049 0.019 -9999.0 0.0 -0.278 1.0 1.0 LCK 0.039 0.009 -9999.0 0.0 0.0 25.0 25.0 SHC1 0.039 0.008 -9999.0 0.0 0.0 23.0 23.0 NOX4 0.021 0.021 -9999.0 0.0 0.0 277.0 277.0