IL6-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.081 0.346 0.486 2.0 -0.77 86.0 88.0 CRP -0.08 0.33 0.5 1.0 -0.765 77.0 78.0 cell cycle arrest -0.116 0.387 -9999.0 0.0 -0.839 97.0 97.0 TIMP1 -0.102 0.364 -9999.0 0.0 -0.749 112.0 112.0 IL6ST 0.025 0.036 -9999.0 0.0 -0.039 96.0 96.0 Rac1/GDP -0.008 0.171 0.294 7.0 -0.352 69.0 76.0 AP1 -0.027 0.207 -9999.0 0.0 -0.479 65.0 65.0 GAB2 0.032 0.02 -9999.0 0.0 -0.001 138.0 138.0 TNFSF11 -0.084 0.328 -9999.0 0.0 -0.761 79.0 79.0 HSP90B1 0.011 0.093 -9999.0 0.0 -1.136 2.0 2.0 GAB1 0.038 0.014 -9999.0 0.0 -0.001 60.0 60.0 MAPK14 -0.029 0.166 0.206 1.0 -0.522 40.0 41.0 AKT1 -0.004 0.152 0.268 5.0 -0.424 36.0 41.0 FOXO1 -0.005 0.145 0.262 3.0 -0.404 36.0 39.0 MAP2K6 -0.021 0.15 0.213 2.0 -0.383 56.0 58.0 mol:GTP -0.0 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K4 -0.034 0.205 0.312 9.0 -0.401 92.0 101.0 MITF -0.016 0.146 0.212 9.0 -0.33 66.0 75.0 positive regulation of NF-kappaB transcription factor activity -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.036 0.013 -9999.0 0.0 0.0 65.0 65.0 A2M -0.122 0.41 -9999.0 0.0 -1.219 66.0 66.0 CEBPB 0.036 0.014 -9999.0 0.0 0.0 72.0 72.0 GRB2/SOS1/GAB family/SHP2 -0.009 0.165 0.313 3.0 -0.404 56.0 59.0 STAT3 -0.141 0.42 -9999.0 0.0 -0.933 95.0 95.0 STAT1 -0.071 0.283 -9999.0 0.0 -0.831 64.0 64.0 CEBPD -0.083 0.338 0.522 2.0 -0.773 80.0 82.0 PIK3CA 0.029 0.02 -9999.0 0.0 -0.001 168.0 168.0 PI3K 0.023 0.06 -9999.0 0.0 -0.146 46.0 46.0 JUN 0.036 0.014 -9999.0 0.0 0.0 76.0 76.0 PIAS3/MITF -0.004 0.146 0.235 3.0 -0.321 60.0 63.0 MAPK11 -0.026 0.156 -9999.0 0.0 -0.54 36.0 36.0 STAT3 (dimer)/FOXO1 -0.089 0.355 0.406 2.0 -0.725 102.0 104.0 GRB2/SOS1/GAB family 0.03 0.128 0.303 4.0 -0.264 39.0 43.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK 0.001 0.111 0.188 3.0 -0.261 58.0 61.0 GRB2 0.041 0.01 -9999.0 0.0 -0.002 22.0 22.0 JAK2 0.034 0.016 -9999.0 0.0 0.0 101.0 101.0 LBP -0.031 0.263 0.474 1.0 -0.577 70.0 71.0 PIK3R1 0.034 0.017 -9999.0 0.0 -0.001 102.0 102.0 JAK1 0.032 0.029 -9999.0 0.0 -0.043 58.0 58.0 MYC -0.071 0.418 0.511 6.0 -0.871 97.0 103.0 FGG -0.083 0.328 -9999.0 0.0 -0.747 82.0 82.0 macrophage differentiation -0.116 0.387 -9999.0 0.0 -0.839 97.0 97.0 IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 0.049 0.103 -9999.0 0.0 -0.168 53.0 53.0 JUNB -0.097 0.39 0.5 7.0 -0.846 97.0 104.0 FOS 0.026 0.02 -9999.0 0.0 0.0 201.0 201.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.01 0.157 0.22 6.0 -0.334 71.0 77.0 STAT1/PIAS1 -0.015 0.182 0.283 2.0 -0.353 81.0 83.0 GRB2/SOS1/GAB family/SHP2/PI3K -0.008 0.152 -9999.0 0.0 -0.406 43.0 43.0 STAT3 (dimer) -0.136 0.41 -9999.0 0.0 -0.91 95.0 95.0 PRKCD -0.058 0.261 0.338 10.0 -0.511 103.0 113.0 IL6R 0.032 0.028 -9999.0 0.0 -0.043 47.0 47.0 SOCS3 -0.042 0.22 -9999.0 0.0 -0.956 25.0 25.0 gp130 (dimer)/JAK1/JAK1/LMO4 0.042 0.088 -9999.0 0.0 -0.142 61.0 61.0 Rac1/GTP -0.013 0.187 0.3 7.0 -0.358 83.0 90.0 HCK 0.037 0.014 -9999.0 0.0 0.0 65.0 65.0 MAPKKK cascade -0.022 0.216 -9999.0 0.0 -0.498 71.0 71.0 bone resorption -0.077 0.311 -9999.0 0.0 -0.714 79.0 79.0 IRF1 -0.141 0.422 -9999.0 0.0 -0.935 107.0 107.0 mol:GDP -0.022 0.152 0.217 4.0 -0.327 74.0 78.0 SOS1 0.039 0.015 -9999.0 0.0 -0.001 53.0 53.0 VAV1 -0.022 0.154 0.218 4.0 -0.327 76.0 80.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.015 0.183 -9999.0 0.0 -0.463 57.0 57.0 PTPN11 0.001 0.163 -9999.0 0.0 -0.786 21.0 21.0 IL6/IL6RA 0.03 0.061 -9999.0 0.0 -0.13 41.0 41.0 gp130 (dimer)/TYK2/TYK2/LMO4 0.048 0.066 -9999.0 0.0 -0.111 46.0 46.0 gp130 (dimer)/JAK2/JAK2/LMO4 0.039 0.077 -9999.0 0.0 -0.123 68.0 68.0 IL6 0.023 0.036 -9999.0 0.0 -0.042 87.0 87.0 PIAS3 0.038 0.012 -9999.0 0.0 0.0 47.0 47.0 PTPRE 0.027 0.037 0.095 16.0 -0.045 48.0 64.0 PIAS1 0.039 0.008 -9999.0 0.0 0.0 24.0 24.0 RAC1 0.039 0.009 -9999.0 0.0 0.0 28.0 28.0 IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 0.001 0.091 0.161 3.0 -0.232 44.0 47.0 LMO4 0.028 0.037 -9999.0 0.0 -0.039 110.0 110.0 STAT3 (dimer)/PIAS3 -0.099 0.391 -9999.0 0.0 -0.837 94.0 94.0 MCL1 0.004 0.162 -9999.0 0.0 -0.656 15.0 15.0