rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p q 1 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(1), ATM(16), BUB1(6), BUB1B(1), BUB3(1), CCNA1(2), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(3), CCND2(1), CCND3(2), CCNE2(1), CCNH(2), CDAN1(4), CDC14A(4), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(2), CDC6(2), CDC7(2), CDH1(12), CDK2(2), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(3), DTX4(3), E2F5(1), EP300(10), ESPL1(5), GSK3B(1), HDAC1(2), HDAC2(3), HDAC3(3), HDAC4(6), HDAC5(3), HDAC6(3), HDAC8(3), MAD1L1(4), MAD2L2(1), MCM2(9), MCM3(3), MCM4(4), MCM5(3), MCM6(1), MCM7(3), MDM2(2), MPEG1(4), ORC1L(9), ORC2L(1), ORC3L(4), ORC4L(2), ORC6L(1), PCNA(2), PLK1(4), PRKDC(18), PTPRA(4), RB1(6), RBL1(3), SKP2(2), SMAD4(5), TBC1D8(4), TGFB1(2), TP53(56), WEE1(1) 22527407 284 93 267 74 45 101 55 16 63 4 <1.00e-15 <1.44e-13 2 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(1), CDKN2A(2), MDM2(2), PIK3CA(23), PIK3R1(5), POLR1A(7), POLR1B(2), POLR1C(2), POLR1D(1), RB1(6), TBX2(3), TP53(56) 4062884 110 76 84 17 25 30 23 3 27 2 <1.00e-15 <1.44e-13 3 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(2), BAK1(1), BID(1), BIRC2(1), BIRC3(3), CASP2(2), CASP3(1), CASP7(2), CASP8(3), CASP9(1), CYCS(1), FAS(1), JUN(2), MAP2K4(5), MAP3K1(5), MAP3K14(1), MAPK10(3), MDM2(2), NFKB1(4), PARP1(4), PRF1(1), RELA(2), TNF(1), TNFRSF1A(3), TNFSF10(2), TP53(56), TRAF2(2) 7658938 112 74 99 21 22 38 16 5 29 2 <1.00e-15 <1.44e-13 4 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(2), EGFR(7), IGF1R(11), POLR2A(6), PPP2CA(1), RB1(6), TEP1(10), TERF1(1), TERT(3), TNKS(5), TP53(56), XRCC5(2) 5739615 110 65 96 33 22 35 21 4 26 2 <1.00e-15 <1.44e-13 5 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), AKT1(2), AKT2(1), AKT3(3), APAF1(2), ATM(16), BAD(1), BID(1), BIRC2(1), BIRC3(3), CAPN1(1), CAPN2(3), CASP10(2), CASP3(1), CASP7(2), CASP8(3), CASP9(1), CSF2RB(5), CYCS(1), DFFA(2), DFFB(2), ENDOG(1), FAS(1), IKBKB(3), IL1B(1), IL1R1(2), IL1RAP(3), IL3(1), IRAK1(4), IRAK2(4), IRAK3(2), IRAK4(1), MAP3K14(1), MYD88(2), NFKB1(4), NFKB2(2), NTRK1(3), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RELA(2), TNF(1), TNFRSF10A(2), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(2), TNFRSF1A(3), TNFSF10(2), TP53(56), TRAF2(2) 16869188 233 92 206 53 54 79 46 12 38 4 1.78e-15 1.44e-13 6 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(2), APAF1(2), ATM(16), BAD(1), BID(1), CASP3(1), CASP7(2), CASP9(1), CYCS(1), EIF2S1(1), PTK2(5), PXN(2), STAT1(3), TLN1(9), TP53(56) 5572700 103 67 89 15 21 32 19 3 24 4 1.78e-15 1.44e-13 7 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(2), SP1(2), SP3(2), TP53(56), WT1(1) 1415785 63 54 50 9 10 19 9 2 21 2 2.33e-15 1.44e-13 8 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(2), CDC42(1), DLD(2), DUSP10(2), DUSP8(1), GCK(2), IL1R1(2), JUN(2), MAP2K4(5), MAP2K5(1), MAP2K7(8), MAP3K1(5), MAP3K10(5), MAP3K11(3), MAP3K12(3), MAP3K13(2), MAP3K2(2), MAP3K3(1), MAP3K4(5), MAP3K7(7), MAP3K9(3), MAPK10(3), MAPK7(8), MAPK8(4), MAPK9(1), MYEF2(3), NFATC3(3), NR2C2(3), PAPPA(12), SHC1(3), TP53(56), TRAF6(3), ZAK(2) 10285023 165 76 152 37 29 65 22 9 38 2 2.44e-15 1.44e-13 9 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(16), ATR(5), BRCA1(6), BRCA2(14), CHEK1(2), CHEK2(3), FANCC(2), FANCD2(6), FANCF(1), FANCG(3), HUS1(1), MRE11A(2), RAD1(1), RAD50(6), RAD51(1), RAD9A(1), TP53(56) 8856603 126 72 112 16 21 36 31 4 30 4 2.66e-15 1.44e-13 10 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(16), ATR(5), BRCA1(6), CCNB1(1), CDC25A(2), CDC25B(4), CDC25C(2), CDC34(1), CDKN1A(1), CDKN2D(1), CHEK1(2), CHEK2(3), EP300(10), MDM2(2), PRKDC(18), RPS6KA1(2), TP53(56), WEE1(1), YWHAQ(2) 8663886 135 76 121 19 20 43 26 4 38 4 3.22e-15 1.44e-13 11 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(2), ATM(16), CDK2(2), CDKN1A(1), MDM2(2), PCNA(2), RB1(6), TIMP3(2), TP53(56) 3699794 89 65 74 8 13 25 18 4 25 4 3.22e-15 1.44e-13 12 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(16), CDC25A(2), CDC25B(4), CDC25C(2), CDK2(2), CHEK1(2), RB1(6), TP53(56), WEE1(1) 3556420 91 65 76 5 14 25 19 3 26 4 3.22e-15 1.44e-13 13 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(1), IFNG(2), IFNGR1(2), IFNGR2(1), IKBKB(3), JAK2(4), LIN7A(6), NFKB1(4), RB1(6), RELA(2), TNF(1), TNFRSF1A(3), TP53(56), USH1C(1), WT1(1) 3793027 93 63 78 15 14 30 17 3 27 2 3.55e-15 1.44e-13 14 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(1), ATM(16), ATR(5), CCNA1(2), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(2), GSK3B(1), HDAC1(2), RB1(6), SKP2(2), TGFB1(2), TGFB2(4), TGFB3(3), TP53(56) 6037269 111 69 96 21 20 32 24 4 27 4 3.66e-15 1.44e-13 15 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(8), AKT1(2), ATM(16), CDKN1A(1), CPB2(4), HIF1A(1), IGFBP3(4), MAPK8(4), MDM2(2), NFKBIB(3), NQO1(3), TP53(56) 4241104 104 71 90 16 20 30 20 2 28 4 3.77e-15 1.44e-13 16 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(2), ATM(16), ATR(5), BAI1(6), BID(1), CASP3(1), CASP8(3), CASP9(1), CCNB1(1), CCNB2(1), CCNB3(3), CCND2(1), CCND3(2), CCNE2(1), CCNG2(1), CD82(1), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(3), CYCS(1), DDB2(2), EI24(1), FAS(1), GTSE1(2), IGF1(2), IGFBP3(4), LRDD(4), MDM2(2), PERP(1), PPM1D(3), PTEN(5), RFWD2(4), RPRM(3), RRM2(1), RRM2B(1), SERPINB5(3), SERPINE1(1), SESN2(1), SESN3(2), SIAH1(1), STEAP3(4), THBS1(5), TNFRSF10B(1), TP53(56), TP73(4), TSC2(3), ZMAT3(1) 13299202 179 84 165 40 40 60 30 9 36 4 4.00e-15 1.44e-13 17 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(2), BAD(1), BAK1(1), BCL2L11(1), BID(1), BIRC2(1), BIRC3(3), BIRC5(1), CASP1(2), CASP10(2), CASP2(2), CASP3(1), CASP4(2), CASP7(2), CASP8(3), CASP9(1), CYCS(1), DFFA(2), DFFB(2), FAS(1), HELLS(3), IKBKB(3), IRF2(8), IRF3(3), IRF4(1), IRF5(1), IRF6(2), IRF7(1), JUN(2), LTA(1), MAP2K4(5), MAP3K1(5), MAPK10(3), MDM2(2), NFKB1(4), NFKBIB(3), PLEKHG5(5), PRF1(1), RELA(2), TNF(1), TNFRSF10B(1), TNFRSF1A(3), TNFRSF21(3), TNFRSF25(2), TNFSF10(2), TP53(56), TP73(4), TRAF2(2), TRAF3(2) 11722221 163 81 150 32 31 56 26 12 36 2 4.11e-15 1.44e-13 18 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 DNAJC3(1), EIF2S1(1), EIF2S2(2), MAP3K14(1), NFKB1(4), RELA(2), TP53(56) 2047003 67 57 54 5 10 21 9 3 22 2 4.22e-15 1.44e-13 19 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(16), ATR(5), CDC25C(2), CHEK1(2), CHEK2(3), TP53(56) 3208226 84 65 70 7 13 26 15 2 24 4 4.44e-15 1.44e-13 20 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(1), ATM(16), BRCA1(6), CDKN1A(1), CHEK1(2), CHEK2(3), JUN(2), MAPK8(4), MDM2(2), MRE11A(2), NFKB1(4), RAD50(6), RAD51(1), RBBP8(3), RELA(2), TP53(56), TP73(4) 6053495 115 72 101 13 21 36 20 4 30 4 4.88e-15 1.50e-13 21 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(2), CDK2(2), CDKN1A(1), CDKN2A(2), CFL1(1), MDM2(2), NXT1(2), PRB1(1), TP53(56) 1630580 69 58 56 6 11 23 7 4 22 2 5.55e-15 1.63e-13 22 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(11), DAXX(3), PAX3(3), PML(2), RARA(1), RB1(6), SIRT1(3), SP100(3), TNF(1), TNFRSF1A(3), TP53(56) 3911663 92 68 78 19 18 29 15 3 25 2 6.55e-15 1.83e-13 23 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(16), CCNA1(2), CCNB1(1), CCND2(1), CCND3(2), CCNE2(1), CCNG2(1), CCNH(2), CDC25A(2), CDK2(2), CDKN1A(1), CDKN2A(2), CDKN2D(1), CREB3(3), CREB3L1(2), CREB3L3(3), CREB3L4(1), E2F5(1), GBA2(2), MCM2(9), MCM3(3), MCM4(4), MCM5(3), MCM6(1), MCM7(3), MDM2(2), MNAT1(2), NACA(1), ORC1L(9), ORC2L(1), ORC3L(4), ORC4L(2), ORC6L(1), PCNA(2), POLA2(1), POLE2(1), PRIM1(1), RB1(6), RBL1(3), RPA1(1), RPA2(1), RPA3(1), TFDP2(2), TNXB(20), TP53(56), WEE1(1) 15636943 187 79 172 42 37 66 36 8 36 4 2.69e-14 7.20e-13 24 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(4), ACVR1C(3), AKT1(2), AKT2(1), AKT3(3), ARRB1(3), ARRB2(2), BDNF(1), BRAF(5), CACNA1A(9), CACNA1B(1), CACNA1C(17), CACNA1D(12), CACNA1E(16), CACNA1F(2), CACNA1G(10), CACNA1H(10), CACNA1I(7), CACNA1S(9), CACNA2D1(5), CACNA2D2(5), CACNA2D3(5), CACNA2D4(8), CACNB1(1), CACNB2(7), CACNB4(3), CACNG3(2), CACNG4(3), CACNG5(2), CACNG6(1), CACNG7(2), CASP3(1), CD14(1), CDC25B(4), CDC42(1), CRK(1), DAXX(3), DDIT3(3), DUSP1(1), DUSP10(2), DUSP16(3), DUSP2(1), DUSP5(3), DUSP6(1), DUSP8(1), DUSP9(2), ECSIT(1), EGF(4), EGFR(7), ELK1(2), ELK4(3), FAS(1), FGF1(2), FGF10(4), FGF11(1), FGF12(3), FGF13(3), FGF14(3), FGF17(2), FGF18(2), FGF2(1), FGF20(1), FGF22(4), FGF23(1), FGF5(1), FGF6(3), FGF7(1), FGF9(4), FGFR1(6), FGFR2(5), FGFR3(1), FGFR4(5), FLNA(5), FLNB(3), FLNC(18), GNA12(1), GNG12(1), GRB2(1), IKBKB(3), IL1B(1), IL1R1(2), JUN(2), KRAS(7), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K5(1), MAP2K6(2), MAP2K7(8), MAP3K1(5), MAP3K10(5), MAP3K12(3), MAP3K13(2), MAP3K14(1), MAP3K2(2), MAP3K3(1), MAP3K4(5), MAP3K6(5), MAP3K7(7), MAP4K1(2), MAP4K2(3), MAP4K3(2), MAP4K4(4), MAPK1(2), MAPK10(3), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(8), MAPK8(4), MAPK8IP1(1), MAPK8IP3(7), MAPK9(1), MAPKAPK3(3), MAPKAPK5(1), MAPT(4), MEF2C(1), MKNK1(1), MOS(3), NF1(12), NFATC2(5), NFATC4(9), NFKB1(4), NFKB2(2), NLK(3), NR4A1(1), NTF3(2), NTRK1(3), NTRK2(4), PAK1(2), PAK2(3), PDGFA(1), PDGFB(3), PDGFRA(2), PDGFRB(5), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PPM1A(2), PPM1B(5), PPP3CA(2), PPP3CB(1), PPP3R2(1), PPP5C(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKCG(4), PRKX(1), PTPN7(2), PTPRR(4), RAC2(1), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF2(6), RASA1(10), RASA2(6), RASGRF1(4), RASGRF2(7), RASGRP1(3), RASGRP2(2), RASGRP3(1), RASGRP4(2), RPS6KA1(2), RPS6KA2(6), RPS6KA4(2), RPS6KA6(6), RRAS(1), RRAS2(1), SOS1(3), SOS2(4), SRF(1), STK3(3), STK4(2), STMN1(1), TAOK1(5), TAOK2(6), TAOK3(3), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TGFBR2(4), TNF(1), TNFRSF1A(3), TP53(56), TRAF2(2), TRAF6(3), ZAK(2) 59524017 699 110 675 202 163 263 115 53 99 6 3.09e-14 7.92e-13 25 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ABL1(1), ANAPC1(13), ANAPC2(3), ANAPC4(2), ANAPC5(2), ANAPC7(1), ATM(16), ATR(5), BUB1(6), BUB1B(1), BUB3(1), CCNA1(2), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(3), CCND2(1), CCND3(2), CCNE2(1), CCNH(2), CDC14A(4), CDC20(2), CDC23(4), CDC25A(2), CDC25B(4), CDC25C(2), CDC26(1), CDC27(1), CDC6(2), CDC7(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(2), CDKN2D(1), CHEK1(2), CHEK2(3), CREBBP(11), CUL1(5), DBF4(4), EP300(10), ESPL1(5), FZR1(3), GSK3B(1), HDAC1(2), HDAC2(3), MAD1L1(4), MAD2L2(1), MCM2(9), MCM3(3), MCM4(4), MCM5(3), MCM6(1), MCM7(3), MDM2(2), ORC1L(9), ORC2L(1), ORC3L(4), ORC4L(2), ORC6L(1), PCNA(2), PKMYT1(1), PLK1(4), PRKDC(18), RB1(6), RBL1(3), RBL2(1), SKP2(2), SMAD2(7), SMAD3(2), SMAD4(5), SMC1A(3), SMC1B(2), TGFB1(2), TGFB2(4), TGFB3(3), TP53(56), WEE1(1), YWHAG(1), YWHAQ(2), YWHAZ(1) 27786227 321 95 297 97 53 106 70 19 69 4 4.93e-14 1.21e-12 26 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(18), AXIN1(8), CD14(1), CTNNB1(8), DVL1(3), FZD1(7), GJA1(7), GNAI1(1), GSK3B(1), IRAK1(4), LEF1(3), LY96(1), MYD88(2), NFKB1(4), PDPK1(1), PIK3CA(23), PIK3R1(5), PPP2CA(1), RELA(2), TIRAP(1), TLR4(9), TOLLIP(1), WNT1(3) 6144600 116 65 100 32 29 29 34 4 16 4 5.44e-14 1.29e-12 27 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), ADRA1A(4), ADRA1B(2), ADRA1D(1), ADRB1(2), ADRB2(2), ADRB3(1), ANXA6(2), ARRB1(3), ARRB2(2), ATP1A4(5), ATP1B3(1), ATP2A2(4), ATP2A3(3), ATP2B1(8), ATP2B2(7), ATP2B3(7), CACNA1A(9), CACNA1B(1), CACNA1C(17), CACNA1D(12), CACNA1E(16), CACNA1S(9), CACNB1(1), CALM1(1), CALM2(2), CALM3(1), CALR(4), CAMK1(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CAMK4(2), CASQ1(2), CASQ2(1), CHRM1(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(3), GJA1(7), GJA4(4), GJB3(2), GJB6(2), GNA11(1), GNAI2(3), GNAI3(3), GNAQ(1), GNAZ(5), GNB1(1), GNB2(3), GNB3(1), GNB4(3), GNG12(1), GNG7(2), GNGT1(2), GRK4(1), GRK5(1), ITPR1(13), ITPR2(12), ITPR3(10), KCNB1(3), KCNJ3(3), MIB1(1), NME7(1), PLCB3(6), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PRKCD(2), PRKCE(3), PRKCG(4), PRKCH(2), PRKCQ(1), PRKD1(5), RGS10(2), RGS11(1), RGS14(1), RGS16(2), RGS17(1), RGS18(3), RGS2(1), RGS20(2), RGS3(7), RGS5(1), RGS6(6), RGS7(1), RGS9(2), RYR1(24), RYR2(31), RYR3(27), SLC8A1(3), SLC8A3(5), USP5(3), YWHAQ(2) 38763648 451 94 446 177 124 148 91 35 53 0 8.76e-13 2.00e-11 28 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(18), APC2(4), AXIN1(8), AXIN2(1), BTRC(2), CACYBP(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CCND2(1), CCND3(2), CHD8(5), CREBBP(11), CSNK1A1L(1), CSNK1E(5), CSNK2A1(4), CSNK2A2(1), CTBP1(2), CTBP2(2), CTNNB1(8), CTNNBIP1(1), CUL1(5), CXXC4(2), DAAM1(5), DAAM2(4), DKK1(4), DKK2(2), DKK4(2), DVL1(3), DVL2(2), DVL3(3), EP300(10), FBXW11(4), FZD1(7), FZD10(7), FZD2(1), FZD3(1), FZD6(7), FZD7(2), FZD8(3), GSK3B(1), JUN(2), LEF1(3), LRP5(8), LRP6(3), MAP3K7(7), MAPK10(3), MAPK8(4), MAPK9(1), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), NKD1(4), NKD2(1), NLK(3), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PORCN(3), PPARD(4), PPP2CA(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(2), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRICKLE1(6), PRICKLE2(10), PRKACA(1), PRKACB(2), PRKACG(2), PRKCG(4), PRKX(1), PSEN1(1), RAC2(1), RHOA(4), ROCK1(5), ROCK2(2), RUVBL1(3), SENP2(2), SFRP1(2), SFRP2(1), SFRP4(1), SFRP5(1), SIAH1(1), SMAD2(7), SMAD3(2), SMAD4(5), SOX17(4), TBL1X(2), TBL1XR1(2), TCF7(1), TCF7L1(3), TCF7L2(3), TP53(56), VANGL1(1), WIF1(1), WNT1(3), WNT10A(3), WNT10B(1), WNT16(2), WNT2(2), WNT2B(5), WNT3(3), WNT3A(1), WNT5A(2), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1), WNT9A(2) 33302668 432 99 409 134 98 154 75 23 76 6 1.85e-12 4.07e-11 29 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAK1(1), BFAR(1), BTK(1), CAD(4), CASP10(2), CASP3(1), CASP8(3), CASP8AP2(4), DAXX(3), DEDD(1), DEDD2(1), DFFA(2), DIABLO(1), EGFR(7), EPHB2(10), FAF1(3), FAIM2(1), HSPB1(1), IL8(1), MAP2K4(5), MAP2K7(8), MAP3K1(5), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP3(7), MAPK9(1), MET(3), NFAT5(5), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), NR0B2(1), PFN2(2), PTPN13(10), RALBP1(7), ROCK1(5), SMPD1(3), TP53(56), TPX2(4), TRAF2(2), TUFM(3) 15170778 200 77 184 61 39 69 31 13 46 2 1.45e-11 3.07e-10 30 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(3), ACTN1(2), ACTN2(11), ACTN3(1), ACTN4(1), ACVR1B(4), ACVR1C(3), CDC42(1), CDH1(12), CREBBP(11), CSNK2A1(4), CSNK2A2(1), CTNNA1(3), CTNNA2(9), CTNNA3(5), CTNNB1(8), CTNND1(5), EGFR(7), EP300(10), ERBB2(4), FARP2(2), FER(6), FGFR1(6), FYN(3), IGF1R(11), INSR(7), IQGAP1(3), LEF1(3), LMO7(4), MAP3K7(7), MAPK1(2), MAPK3(1), MET(3), MLLT4(12), NLK(3), PARD3(6), PTPRB(10), PTPRF(6), PTPRJ(12), PTPRM(15), PVRL1(2), PVRL2(1), PVRL3(3), PVRL4(4), RAC2(1), RHOA(4), SMAD2(7), SMAD3(2), SMAD4(5), SNAI1(1), SNAI2(4), SORBS1(5), SSX2IP(3), TCF7(1), TCF7L1(3), TCF7L2(3), TGFBR1(1), TGFBR2(4), TJP1(4), VCL(2), WASF1(3), WASF2(2), WASF3(3), WASL(1), YES1(2) 24108245 298 77 292 93 79 102 43 23 51 0 4.48e-09 9.20e-08 31 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(6), CADM1(8), CADM3(4), CD2(2), CD226(2), CD274(1), CD276(2), CD34(2), CD4(3), CD40(1), CD40LG(3), CD58(1), CD6(5), CD80(1), CD86(2), CD8A(1), CDH1(12), CDH2(7), CDH3(5), CDH4(8), CDH5(2), CLDN1(1), CLDN10(1), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(1), CLDN23(3), CLDN4(2), CLDN6(1), CLDN9(2), CNTN1(9), CNTN2(3), CNTNAP1(10), CNTNAP2(10), CTLA4(2), ESAM(4), GLG1(4), HLA-A(8), HLA-B(10), HLA-C(4), HLA-DMA(1), HLA-DMB(2), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DRA(2), HLA-DRB1(1), HLA-E(3), HLA-F(4), ICAM1(2), ICAM2(2), ICAM3(1), ICOS(1), ITGA4(7), ITGA6(2), ITGA8(3), ITGA9(6), ITGAL(6), ITGAM(4), ITGAV(2), ITGB1(2), ITGB2(5), ITGB7(2), ITGB8(6), JAM3(2), L1CAM(3), MADCAM1(2), MAG(4), MPZ(2), NCAM2(6), NEGR1(3), NEO1(6), NFASC(8), NLGN1(6), NLGN2(4), NLGN3(4), NRCAM(4), NRXN1(11), NRXN2(12), NRXN3(10), PDCD1LG2(1), PTPRC(13), PTPRF(6), PTPRM(15), PVR(2), PVRL1(2), PVRL2(1), PVRL3(3), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SELE(2), SELL(3), SELP(2), SELPLG(5), SIGLEC1(8), VCAM1(4), VCAN(19) 30468970 413 94 410 155 88 162 87 33 41 2 1.15e-08 2.29e-07 32 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTB(3), ARHGEF2(2), CD14(1), CDC42(1), CDH1(12), CLDN1(1), CTNNB1(8), CTTN(1), FYN(3), HCLS1(1), ITGB1(2), KRT18(3), LY96(1), NCK1(2), NCK2(2), NCL(3), RHOA(4), ROCK1(5), ROCK2(2), TLR4(9), TLR5(1), TUBA1C(2), TUBA3C(6), TUBA3D(3), TUBA3E(3), TUBA8(3), TUBAL3(2), TUBB1(2), TUBB2A(1), TUBB2C(2), TUBB4Q(2), TUBB6(3), TUBB8(2), WASL(1), YWHAQ(2), YWHAZ(1) 10705037 103 55 99 49 23 36 26 9 9 0 1.54e-08 2.88e-07 33 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTB(3), ARHGEF2(2), CD14(1), CDC42(1), CDH1(12), CLDN1(1), CTNNB1(8), CTTN(1), FYN(3), HCLS1(1), ITGB1(2), KRT18(3), LY96(1), NCK1(2), NCK2(2), NCL(3), RHOA(4), ROCK1(5), ROCK2(2), TLR4(9), TLR5(1), TUBA1C(2), TUBA3C(6), TUBA3D(3), TUBA3E(3), TUBA8(3), TUBAL3(2), TUBB1(2), TUBB2A(1), TUBB2C(2), TUBB4Q(2), TUBB6(3), TUBB8(2), WASL(1), YWHAQ(2), YWHAZ(1) 10705037 103 55 99 49 23 36 26 9 9 0 1.54e-08 2.88e-07 34 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(18), CDH1(12), CREBBP(11), EP300(10), MAP2K1(3), MAP3K7(7), MAPK3(1), SKIL(3), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TGFBR2(4) 5153750 79 42 78 20 19 24 14 3 17 2 2.10e-08 3.80e-07 35 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(2), HLA-A(8), ITGB1(2), KLRC1(1), KLRC2(1), KLRD1(1), MAP2K1(3), MAPK3(1), PAK1(2), PIK3CA(23), PIK3R1(5), PTK2B(8), SYK(1), VAV1(2) 3753526 60 43 48 16 16 10 20 4 10 0 4.22e-08 7.43e-07 36 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ACTA2(5), ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), ARRB1(3), ARRB2(2), ATF5(3), ATP2A2(4), ATP2A3(3), CALCA(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CNN1(1), CORIN(4), CREB3(3), CRHR1(1), DGKZ(1), ETS2(1), GABPA(1), GABPB2(1), GBA2(2), GJA1(7), GNAQ(1), GNB1(1), GNB2(3), GNB3(1), GNB4(3), GNG12(1), GNG7(2), GNGT1(2), GRK4(1), GRK5(1), GUCA2A(1), GUCY1A3(7), IGFBP1(2), IGFBP2(1), IGFBP3(4), IL1B(1), IL6(1), ITPR1(13), ITPR2(12), ITPR3(10), JUN(2), MIB1(1), MYL2(1), MYL4(1), MYLK2(2), NFKB1(4), NOS1(15), NOS3(2), OXT(2), OXTR(3), PDE4B(4), PLCB3(6), PLCG1(9), PLCG2(5), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PRKCD(2), PRKCE(3), PRKCH(2), PRKCQ(1), PRKD1(5), RAMP2(1), RAMP3(3), RGS10(2), RGS11(1), RGS14(1), RGS16(2), RGS17(1), RGS18(3), RGS2(1), RGS20(2), RGS3(7), RGS5(1), RGS6(6), RGS7(1), RGS9(2), RYR1(24), RYR2(31), RYR3(27), SLC8A1(3), SP1(2), TNXB(20), USP5(3), YWHAQ(2) 35609952 401 88 397 159 121 126 78 34 42 0 5.46e-08 9.35e-07 37 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(5), CPEB1(2), EGFR(7), ERBB2(4), ERBB4(12), ETS1(3), ETS2(1), ETV6(3), ETV7(1), FMN2(14), GRB2(1), KRAS(7), MAP2K1(3), MAPK1(2), MAPK3(1), NOTCH1(9), NOTCH2(9), NOTCH3(8), NOTCH4(6), PIWIL1(2), PIWIL2(6), PIWIL3(2), PIWIL4(1), RAF1(6), SOS1(3), SOS2(4), SPIRE1(2) 10776857 124 61 116 54 28 44 26 12 14 0 1.78e-07 2.96e-06 38 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTA2(5), ACTN2(11), ACTN3(1), ACTN4(1), DES(1), DMD(16), FAM48A(3), MYBPC1(1), MYBPC2(4), MYBPC3(3), MYH3(13), MYH6(7), MYH7(11), MYH8(7), MYL1(1), MYL2(1), MYL4(1), MYOM1(1), NEB(24), TCAP(1), TMOD1(3), TNNC2(1), TNNI2(3), TNNI3(1), TNNT1(2), TNNT2(1), TPM4(2), TTN(212), VIM(1) 28074172 340 85 337 105 75 103 100 35 23 4 2.22e-07 3.60e-06 39 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(3), ACTN1(2), ACTN2(11), ACTN3(1), ACTN4(1), AKT1(2), AKT2(1), AKT3(3), ARHGAP5(6), BAD(1), BCAR1(3), BIRC2(1), BIRC3(3), BRAF(5), CAPN2(3), CAV1(2), CCND2(1), CCND3(2), CDC42(1), CHAD(3), COL11A1(12), COL11A2(5), COL1A1(6), COL1A2(13), COL2A1(7), COL3A1(6), COL4A1(5), COL4A2(4), COL4A4(4), COL4A6(5), COL5A1(7), COL5A2(4), COL5A3(5), COL6A3(15), COL6A6(15), COMP(1), CRK(1), CTNNB1(8), DIAPH1(3), DOCK1(10), EGF(4), EGFR(7), ELK1(2), ERBB2(4), FARP2(2), FLNA(5), FLNB(3), FLNC(18), FLT1(5), FN1(15), FYN(3), GRB2(1), GRLF1(8), GSK3B(1), HGF(7), IBSP(1), IGF1(2), IGF1R(11), ITGA1(4), ITGA10(4), ITGA11(5), ITGA2(3), ITGA2B(5), ITGA3(6), ITGA4(7), ITGA5(4), ITGA6(2), ITGA7(5), ITGA8(3), ITGA9(6), ITGAV(2), ITGB1(2), ITGB3(5), ITGB4(10), ITGB5(2), ITGB7(2), ITGB8(6), JUN(2), KDR(7), LAMA1(14), LAMA2(11), LAMA3(8), LAMA4(7), LAMA5(13), LAMB1(5), LAMB2(10), LAMB3(11), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(9), MAP2K1(3), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(1), MET(3), MYL2(1), MYLK(7), MYLK2(2), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PARVA(1), PARVB(3), PARVG(2), PDGFA(1), PDGFB(3), PDGFC(2), PDGFD(3), PDGFRA(2), PDGFRB(5), PDPK1(1), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PIP5K1C(5), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PRKCG(4), PTEN(5), PTK2(5), PXN(2), RAC2(1), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF1(6), RELN(15), RHOA(4), ROCK1(5), ROCK2(2), SHC1(3), SHC2(2), SHC3(3), SHC4(1), SOS1(3), SOS2(4), THBS1(5), THBS2(6), THBS3(2), THBS4(2), TLN1(9), TLN2(11), TNC(11), TNN(10), TNR(9), TNXB(20), VASP(2), VAV1(2), VAV2(5), VAV3(6), VCL(2), VEGFC(3), VTN(4), VWF(8), ZYX(2) 75964014 809 108 790 354 230 273 147 64 93 2 2.50e-07 3.95e-06 40 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3E(1), CD3G(2), CD80(1), CD86(2), CTLA4(2), GRB2(1), HLA-DRA(2), HLA-DRB1(1), ICOS(1), IL2(1), ITK(2), LCK(1), PIK3CA(23), PIK3R1(5), PTPN11(3) 2554132 48 36 35 13 15 7 16 4 6 0 5.51e-07 8.41e-06 41 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(23), PIK3R1(5), PLCB1(8), PLCG1(9), VAV1(2) 2576476 49 35 36 13 16 10 16 1 6 0 5.60e-07 8.41e-06 42 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(3), ACTN1(2), ACTN2(11), ACTN3(1), ACTN4(1), APC(18), APC2(4), ARAF(6), ARHGEF1(1), ARHGEF12(5), ARHGEF4(4), ARHGEF6(8), ARHGEF7(7), ARPC1A(1), ARPC1B(1), ARPC4(1), BCAR1(3), BDKRB1(1), BDKRB2(2), BRAF(5), CD14(1), CDC42(1), CFL1(1), CHRM1(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(3), CRK(1), CSK(2), CYFIP1(2), CYFIP2(8), DIAPH1(3), DIAPH2(3), DIAPH3(10), DOCK1(10), EGF(4), EGFR(7), F2(4), F2R(2), FGD1(4), FGD3(5), FGF1(2), FGF10(4), FGF11(1), FGF12(3), FGF13(3), FGF14(3), FGF17(2), FGF18(2), FGF2(1), FGF20(1), FGF22(4), FGF23(1), FGF5(1), FGF6(3), FGF7(1), FGF9(4), FGFR1(6), FGFR2(5), FGFR3(1), FGFR4(5), FN1(15), GIT1(2), GNA12(1), GNG12(1), GRLF1(8), GSN(4), IQGAP1(3), IQGAP2(5), IQGAP3(5), ITGA1(4), ITGA10(4), ITGA11(5), ITGA2(3), ITGA2B(5), ITGA3(6), ITGA4(7), ITGA5(4), ITGA6(2), ITGA7(5), ITGA8(3), ITGA9(6), ITGAD(3), ITGAE(4), ITGAL(6), ITGAM(4), ITGAV(2), ITGAX(5), ITGB1(2), ITGB2(5), ITGB3(5), ITGB4(10), ITGB5(2), ITGB7(2), ITGB8(6), KRAS(7), LIMK1(2), LIMK2(3), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), MOS(3), MSN(3), MYH10(13), MYH14(8), MYH9(13), MYL2(1), MYLK(7), MYLK2(2), NCKAP1(4), NCKAP1L(7), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PDGFA(1), PDGFB(3), PDGFRA(2), PDGFRB(5), PFN2(2), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PIP4K2A(3), PIP4K2B(2), PIP4K2C(1), PIP5K1A(2), PIP5K1C(5), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PPP1R12B(2), PTK2(5), PXN(2), RAC2(1), RAF1(6), RDX(1), RHOA(4), ROCK1(5), ROCK2(2), RRAS(1), RRAS2(1), SCIN(2), SLC9A1(4), SOS1(3), SOS2(4), SSH1(4), SSH2(10), SSH3(2), TIAM1(11), TIAM2(15), TMSL3(1), VAV1(2), VAV2(5), VAV3(6), VCL(2), WASF1(3), WASF2(2), WASL(1) 56845530 662 105 637 244 179 217 132 44 88 2 6.43e-07 9.43e-06 43 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(2), CAT(4), GH1(1), GHR(5), IGF1(2), IGF1R(11), PIK3CA(23), PIK3R1(5), SHC1(3), SOD2(1) 2684206 57 38 45 10 16 14 19 2 6 0 8.17e-07 0.000012 44 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), AKT1(2), ANXA1(3), CALM1(1), CALM2(2), CALM3(1), GNAS(12), GNB1(1), GNGT1(2), NFKB1(4), NOS3(2), NR3C1(3), PIK3CA(23), PIK3R1(5), RELA(2) 3689420 65 41 52 13 16 19 16 5 9 0 2.40e-06 0.000034 45 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), CACNA1C(17), CACNA1D(12), CACNA1F(2), CACNA1S(9), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CDC42(1), EGFR(7), ELK1(2), FSHB(1), GNA11(1), GNAQ(1), GNAS(12), GNRH2(1), GNRHR(2), GRB2(1), ITPR1(13), ITPR2(12), ITPR3(10), JUN(2), KRAS(7), LHB(1), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(8), MAP3K1(5), MAP3K2(2), MAP3K3(1), MAP3K4(5), MAPK1(2), MAPK10(3), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(8), MAPK8(4), MAPK9(1), MMP2(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PLD1(6), PLD2(10), PRKACA(1), PRKACB(2), PRKACG(2), PRKCD(2), PRKX(1), PTK2B(8), RAF1(6), SOS1(3), SOS2(4) 26309794 317 77 313 103 74 126 60 21 36 0 3.03e-06 0.000042 46 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF4E(1), EIF4EBP1(1), GSK3B(1), IGF1(2), IGF1R(11), INPPL1(11), PDPK1(1), PIK3CA(23), PIK3R1(5), PPP2CA(1), PTEN(5), RPS6(1), RPS6KB1(2) 3997315 74 43 61 15 22 18 21 2 11 0 3.55e-06 0.000048 47 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 246 ACVR1(3), ACVR1B(4), ACVR2A(16), ACVR2B(3), AMH(1), AMHR2(3), BMP2(2), BMP7(2), BMPR1A(1), BMPR1B(2), BMPR2(9), CCL18(1), CCL20(1), CCL23(1), CCL27(1), CCL5(1), CCL7(1), CCL8(2), CCR1(1), CCR2(1), CCR3(3), CCR6(1), CCR8(1), CCR9(1), CD27(2), CD40(1), CD40LG(3), CLCF1(1), CNTF(2), CNTFR(2), CSF1R(7), CSF2RB(5), CSF3(1), CSF3R(3), CX3CL1(3), CX3CR1(4), CXCL16(2), CXCL2(1), CXCL9(1), CXCR4(2), EDA(1), EGF(4), EGFR(7), EPOR(2), FAS(1), FLT1(5), FLT3(4), FLT4(6), GDF5(1), GH1(1), GH2(2), GHR(5), HGF(7), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(1), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RA(1), IL10RB(1), IL11(1), IL11RA(1), IL12B(1), IL12RB1(3), IL12RB2(3), IL13(1), IL13RA1(1), IL15RA(1), IL17B(1), IL17RA(6), IL17RB(1), IL18R1(2), IL18RAP(1), IL1B(1), IL1R1(2), IL1RAP(3), IL2(1), IL20(1), IL20RA(1), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23R(5), IL25(2), IL26(1), IL28A(1), IL28B(1), IL2RA(1), IL2RG(2), IL3(1), IL6(1), IL6ST(1), IL7R(3), IL8(1), INHBA(4), INHBB(7), INHBC(1), INHBE(1), KDR(7), KIT(5), KITLG(3), LEPR(7), LIF(2), LIFR(6), LTA(1), LTBR(2), MET(3), NGFR(2), OSM(2), OSMR(3), PDGFB(3), PDGFC(2), PDGFRA(2), PDGFRB(5), PF4V1(1), PRL(1), PRLR(2), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TGFBR2(4), TNF(1), TNFRSF10A(2), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(2), TNFRSF11A(4), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF19(2), TNFRSF1A(3), TNFRSF21(3), TNFRSF25(2), TNFRSF8(2), TNFRSF9(3), TNFSF10(2), TNFSF11(1), TNFSF18(2), TNFSF8(1), TPO(12), TSLP(3), VEGFC(3), XCR1(3) 35324534 377 84 360 143 86 118 86 30 55 2 4.62e-06 0.000061 48 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(6), BRAF(5), CACNA1A(9), CRHR1(1), GNA11(1), GNA12(1), GNAI1(1), GNAI2(3), GNAI3(3), GNAQ(1), GNAS(12), GNAZ(5), GRIA1(6), GRIA2(8), GRIA3(5), GRID2(7), GRM1(11), GRM5(11), GUCY1A2(3), GUCY1A3(7), GUCY1B3(4), GUCY2C(1), GUCY2D(5), GUCY2F(5), IGF1(2), IGF1R(11), ITPR1(13), ITPR2(12), ITPR3(10), KRAS(7), LYN(2), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), NOS1(15), NOS3(2), NPR1(6), NPR2(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PPP2CA(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(2), PRKCG(4), PRKG1(4), PRKG2(6), RAF1(6), RYR1(24) 22640856 305 76 301 97 69 128 63 20 25 0 5.76e-06 0.000074 49 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(3), APC(18), AXIN1(8), BMP10(2), BMP2(2), BMP4(5), BMP5(5), BMP7(2), BMPR1A(1), BMPR2(9), CHRD(1), CTNNB1(8), DVL1(3), FZD1(7), GATA4(2), GSK3B(1), MAP3K7(7), MEF2C(1), MYL2(1), NKX2-5(2), NPPB(1), RFC1(1), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TGFBR2(4), TGFBR3(1), WNT1(3) 7311941 108 49 104 36 30 27 24 5 16 6 8.38e-06 0.00011 50 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY7(8), ADCY8(8), ADCY9(4), ADORA2B(1), ADRA1A(4), ADRA1B(2), ADRA1D(1), ADRB1(2), ADRB2(2), ADRB3(1), AGTR1(1), ATP2A1(3), ATP2A2(4), ATP2A3(3), ATP2B1(8), ATP2B2(7), ATP2B3(7), ATP2B4(1), AVPR1A(5), AVPR1B(1), BDKRB1(1), BDKRB2(2), CACNA1A(9), CACNA1B(1), CACNA1C(17), CACNA1D(12), CACNA1E(16), CACNA1F(2), CACNA1G(10), CACNA1H(10), CACNA1I(7), CACNA1S(9), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CAMK4(2), CCKAR(2), CCKBR(3), CD38(2), CHRM1(1), CHRM2(6), CHRM3(4), CHRM5(3), CHRNA7(1), CYSLTR1(2), DRD1(2), EDNRA(2), EDNRB(10), EGFR(7), ERBB2(4), ERBB3(12), ERBB4(12), F2R(2), GNA11(1), GNA14(1), GNA15(2), GNAQ(1), GNAS(12), GRIN1(3), GRIN2A(7), GRIN2C(2), GRIN2D(1), GRM1(11), GRM5(11), GRPR(3), HRH1(3), HRH2(2), HTR2A(1), HTR2B(4), HTR2C(2), HTR4(3), HTR5A(2), HTR7(3), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), LHCGR(5), LTB4R2(2), MYLK(7), MYLK2(2), NOS1(15), NOS3(2), NTSR1(1), OXTR(3), P2RX3(1), P2RX4(1), P2RX5(2), PDE1A(2), PDE1B(1), PDE1C(2), PDGFRA(2), PDGFRB(5), PHKA1(4), PHKA2(4), PHKB(3), PHKG1(2), PHKG2(2), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PLCD3(5), PLCE1(7), PLCG1(9), PLCG2(5), PLCZ1(2), PPID(1), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKCG(4), PRKX(1), PTAFR(2), PTGER3(2), PTGFR(3), PTK2B(8), RYR1(24), RYR2(31), RYR3(27), SLC25A4(1), SLC25A5(2), SLC8A1(3), SLC8A2(3), SLC8A3(5), SPHK1(4), TACR1(2), TACR2(1), TACR3(4), TBXA2R(6), TNNC1(2), TNNC2(1), TRHR(5), TRPC1(2), VDAC1(1) 55848562 664 99 653 234 182 233 128 50 67 4 0.000011 0.00013 51 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), CRK(1), DOCK1(10), ELK1(2), GRB2(1), HGF(7), ITGA1(4), ITGB1(2), JUN(2), MAP2K1(3), MAP2K2(1), MAP4K1(2), MAPK1(2), MAPK3(1), MAPK8(4), MET(3), PAK1(2), PIK3CA(23), PIK3R1(5), PTEN(5), PTK2(5), PTK2B(8), PTPN11(3), PXN(2), RAF1(6), RAP1A(1), RAP1B(2), RASA1(10), SOS1(3), STAT3(4) 9040276 125 56 110 39 29 38 31 8 17 2 0.000014 0.00016 52 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(2), BDKRB2(2), CALM1(1), CALM2(2), CALM3(1), CAV1(2), CHRM1(1), CHRNA1(3), FLT1(5), FLT4(6), KDR(7), NOS3(2), PDE2A(6), PDE3A(3), PDE3B(9), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PRKG1(4), PRKG2(6), RYR2(31), SLC7A1(1) 8335775 107 59 107 37 30 36 27 11 3 0 0.000016 0.00019 53 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), ADRB1(2), DRD1(2), DRD2(5), EGF(4), EGFR(7), GJA1(7), GJD2(1), GNA11(1), GNAI1(1), GNAI2(3), GNAI3(3), GNAQ(1), GNAS(12), GRB2(1), GRM1(11), GRM5(11), GUCY1A2(3), GUCY1A3(7), GUCY1B3(4), GUCY2C(1), GUCY2D(5), GUCY2F(5), HTR2A(1), HTR2B(4), HTR2C(2), ITPR1(13), ITPR2(12), ITPR3(10), KRAS(7), MAP2K1(3), MAP2K2(1), MAP2K5(1), MAP3K2(2), MAPK1(2), MAPK3(1), MAPK7(8), NPR1(6), NPR2(2), PDGFA(1), PDGFB(3), PDGFC(2), PDGFD(3), PDGFRA(2), PDGFRB(5), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PRKACA(1), PRKACB(2), PRKACG(2), PRKCG(4), PRKG1(4), PRKG2(6), PRKX(1), RAF1(6), SOS1(3), SOS2(4), TJP1(4), TUBA1C(2), TUBA3C(6), TUBA3D(3), TUBA3E(3), TUBA8(3), TUBAL3(2), TUBB1(2), TUBB2A(1), TUBB2C(2), TUBB4Q(2), TUBB6(3), TUBB8(2) 26936490 331 80 326 129 85 124 75 23 24 0 0.000023 0.00027 54 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(18), AXIN1(8), CREBBP(11), CTNNB1(8), DVL1(3), EP300(10), FZD1(7), GSK3B(1), HDAC1(2), LDB1(4), LEF1(3), PITX2(2), TRRAP(19), WNT1(3) 6582968 99 49 97 41 34 27 11 4 19 4 0.000023 0.00027 55 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 86 AGRN(5), CD36(1), CD44(3), CHAD(3), COL11A1(12), COL11A2(5), COL1A1(6), COL1A2(13), COL2A1(7), COL3A1(6), COL4A1(5), COL4A2(4), COL4A4(4), COL4A6(5), COL5A1(7), COL5A2(4), COL5A3(5), COL6A3(15), COL6A6(15), DAG1(7), FN1(15), FNDC1(7), FNDC3A(6), FNDC4(1), GP1BA(1), GP5(2), GP6(1), HMMR(2), HSPG2(14), IBSP(1), ITGA1(4), ITGA10(4), ITGA11(5), ITGA2(3), ITGA2B(5), ITGA3(6), ITGA4(7), ITGA5(4), ITGA6(2), ITGA7(5), ITGA8(3), ITGA9(6), ITGAV(2), ITGB1(2), ITGB3(5), ITGB4(10), ITGB5(2), ITGB7(2), ITGB8(6), LAMA1(14), LAMA2(11), LAMA3(8), LAMA4(7), LAMA5(13), LAMB1(5), LAMB2(10), LAMB3(11), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(9), RELN(15), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SV2A(4), SV2B(1), SV2C(4), THBS1(5), THBS2(6), THBS3(2), THBS4(2), TNC(11), TNN(10), TNR(9), TNXB(20), VTN(4), VWF(8) 46546010 478 87 476 221 137 173 70 35 63 0 0.000032 0.00036 56 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(9), AKT1(2), BAD(1), CSF2RB(5), IGF1(2), IGF1R(11), IL3(1), KIT(5), KITLG(3), PIK3CA(23), PIK3R1(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5) 4200273 79 43 67 24 25 23 22 4 5 0 0.000051 0.00056 57 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(2), EIF4A1(2), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4G1(7), EIF4G2(1), EIF4G3(5), GHR(5), IRS1(5), MAPK1(2), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(2), PDPK1(1), PIK3CA(23), PIK3R1(5), PTEN(5), RPS6KB1(2) 5661145 75 45 63 28 19 19 24 5 8 0 0.000066 0.00071 58 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(4), ELK1(2), GRB2(1), INSR(7), IRS1(5), JUN(2), MAP2K1(3), MAPK3(1), MAPK8(4), PIK3CA(23), PIK3R1(5), PTPN11(3), RAF1(6), RASA1(10), SHC1(3), SLC2A4(1), SOS1(3), SRF(1) 5142046 84 44 71 16 22 24 20 5 11 2 0.000078 0.00082 59 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 237 ADCYAP1R1(5), ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA1B(2), ADRA2A(2), ADRA2B(2), ADRA2C(3), ADRB1(2), ADRB2(2), ADRB3(1), AGTR1(1), AGTR2(1), AVPR1A(5), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(2), C5AR1(1), CALCR(2), CALCRL(4), CCKAR(2), CCKBR(3), CHRM1(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(3), CNR1(4), CRHR1(1), CRHR2(3), CTSG(2), CYSLTR1(2), DRD1(2), DRD2(5), DRD3(7), DRD5(8), EDNRA(2), EDNRB(10), F2(4), F2R(2), F2RL1(3), FPR1(1), FSHB(1), FSHR(11), GABBR1(7), GABBR2(5), GABRA1(5), GABRA2(4), GABRA3(3), GABRA4(2), GABRA5(4), GABRA6(5), GABRB1(1), GABRB2(3), GABRB3(5), GABRE(4), GABRG1(1), GABRG2(8), GABRG3(1), GABRP(4), GABRQ(6), GABRR1(6), GABRR2(5), GALR1(2), GALR3(1), GH1(1), GH2(2), GHR(5), GHSR(4), GLP1R(1), GLP2R(3), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(4), GNRHR(2), GPR156(2), GPR35(3), GPR50(3), GPR83(4), GRIA1(6), GRIA2(8), GRIA3(5), GRIA4(3), GRID1(14), GRID2(7), GRIK1(5), GRIK2(11), GRIK3(7), GRIK4(6), GRIK5(5), GRIN1(3), GRIN2A(7), GRIN2B(9), GRIN2C(2), GRIN2D(1), GRIN3A(5), GRIN3B(2), GRM1(11), GRM2(8), GRM3(3), GRM4(3), GRM5(11), GRM6(4), GRM7(6), GRM8(8), GRPR(3), GZMA(1), HCRTR1(3), HCRTR2(2), HRH1(3), HRH2(2), HTR1A(5), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(3), HTR2A(1), HTR2B(4), HTR2C(2), HTR4(3), HTR5A(2), HTR7(3), LEPR(7), LHB(1), LHCGR(5), LTB4R(2), LTB4R2(2), MAS1(1), MC2R(1), MC3R(3), MC4R(2), MC5R(6), MCHR1(2), MCHR2(2), MLNR(1), MTNR1A(2), MTNR1B(2), NMBR(1), NMUR1(1), NMUR2(1), NPBWR1(6), NPFFR1(1), NPFFR2(2), NPY1R(2), NPY2R(1), NPY5R(1), NR3C1(3), NTSR1(1), OPRD1(1), OPRK1(3), OXTR(3), P2RX3(1), P2RX4(1), P2RX5(2), P2RY1(3), P2RY10(1), P2RY13(4), P2RY14(2), P2RY4(2), PARD3(6), PPYR1(5), PRL(1), PRLHR(2), PRLR(2), PRSS1(3), PRSS3(2), PTAFR(2), PTGDR(5), PTGER2(2), PTGER3(2), PTGER4(1), PTGFR(3), PTH2R(2), RXFP1(4), RXFP2(5), SCTR(2), SSTR1(4), SSTR3(3), SSTR4(6), SSTR5(1), TAAR1(3), TAAR2(1), TAAR5(1), TAAR6(2), TACR1(2), TACR2(1), TACR3(4), TBXA2R(6), THRA(1), THRB(4), TRHR(5), TRPV1(5), TSHB(1), TSHR(5), VIPR1(2) 45330257 650 104 642 177 183 212 151 52 52 0 0.000079 0.00082 60 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), AKT2(1), AKT3(3), BPNT1(2), GRB2(1), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(23), PIK3CD(6), PTEN(5), PTK2B(8), RBL2(1), SHC1(3), SOS1(3) 4116882 62 40 50 21 17 21 17 2 5 0 0.000080 0.00082 61 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(18), AXIN1(8), BTRC(2), CREBBP(11), CSNK2A1(4), CTBP1(2), CTNNB1(8), DVL1(3), FZD1(7), GSK3B(1), HDAC1(2), MAP3K7(7), NLK(3), PPARD(4), PPP2CA(1), TLE1(2), WIF1(1), WNT1(3) 5884585 87 44 85 33 23 30 9 4 17 4 0.000092 0.00093 62 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(18), AXIN1(8), BTRC(2), CTNNB1(8), DLL1(1), DVL1(3), FZD1(7), GSK3B(1), NOTCH1(9), PSEN1(1), WNT1(3) 4339923 62 38 60 32 15 23 7 3 10 4 0.00012 0.0012 63 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(1), AKT3(3), ANKRD6(3), APC(18), AXIN1(8), AXIN2(1), CTNNB1(8), DACT1(2), DKK1(4), DKK2(2), DKK3(1), DKK4(2), DVL1(3), GSK3B(1), LRP1(14), MVP(4), NKD1(4), NKD2(1), PIN1(1), PSEN1(1), PTPRA(4), SENP2(2), SFRP1(2), TSHB(1), WIF1(1) 8172850 94 51 92 30 20 35 16 9 10 4 0.00012 0.0012 64 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(18), AXIN1(8), CCND2(1), CCND3(2), CSNK1E(5), CTNNB1(8), DVL1(3), DVL2(2), DVL3(3), FBXW2(2), FZD1(7), FZD10(7), FZD2(1), FZD3(1), FZD6(7), FZD7(2), FZD8(3), GSK3B(1), JUN(2), LDLR(3), MAPK10(3), MAPK9(1), PAFAH1B1(3), PLAU(1), PPP2R5C(1), PPP2R5E(2), PRKCD(2), PRKCE(3), PRKCG(4), PRKCH(2), PRKCI(4), PRKCQ(1), PRKD1(5), RHOA(4), SFRP4(1), TCF7(1), WNT1(3), WNT10A(3), WNT10B(1), WNT16(2), WNT2(2), WNT2B(5), WNT3(3), WNT5A(2), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1) 12201686 150 59 145 67 37 50 26 9 24 4 0.00013 0.0012 65 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(9), ARHGEF1(1), F2(4), F2R(2), GNA12(1), GNAI1(1), GNAQ(1), GNB1(1), GNGT1(2), MAP3K7(7), PIK3CA(23), PIK3R1(5), PLCB1(8), PPP1R12B(2), PTK2B(8), ROCK1(5) 5254830 80 43 68 28 24 19 24 2 11 0 0.00014 0.0013 66 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(4), EGF(4), EGFR(7), ELK1(2), GRB2(1), JAK1(5), JUN(2), MAP2K1(3), MAP2K4(5), MAP3K1(5), MAPK3(1), MAPK8(4), PIK3CA(23), PIK3R1(5), PLCG1(9), RAF1(6), RASA1(10), SHC1(3), SOS1(3), SRF(1), STAT1(3), STAT3(4) 7545356 110 53 96 26 31 35 20 5 15 4 0.00014 0.0013 67 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(4), ELK1(2), GRB2(1), IGF1(2), IGF1R(11), IRS1(5), JUN(2), MAP2K1(3), MAPK3(1), MAPK8(4), PIK3CA(23), PIK3R1(5), PTPN11(3), RAF1(6), RASA1(10), SHC1(3), SOS1(3), SRF(1) 4984574 89 43 76 15 25 27 22 4 9 2 0.00015 0.0014 68 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(16), BMPR1B(2), CCND2(1), DMC1(1), EGR1(3), ESR2(5), FSHR(11), GJA4(4), INHA(2), LHCGR(5), MLH1(2), MSH5(3), NCOR1(10), NR5A1(4), NRIP1(7), PGR(5), PRLR(2), PTGER2(2), SMPD1(3), VDR(5), ZP2(3) 7088235 96 51 93 24 21 31 27 4 11 2 0.00016 0.0015 69 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(9), AKT1(2), ASAH1(1), GNAI1(1), GNB1(1), GNGT1(2), ITGAV(2), ITGB3(5), MAPK1(2), MAPK3(1), PDGFA(1), PDGFRA(2), PIK3CA(23), PIK3R1(5), PLCB1(8), PTK2(5), SMPD1(3), SPHK1(4) 5493565 77 46 65 32 22 18 23 4 10 0 0.00017 0.0015 70 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(9), ADCY8(8), ARAF(6), BRAF(5), CACNA1C(17), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CAMK4(2), CREBBP(11), EP300(10), GNAQ(1), GRIA1(6), GRIA2(8), GRIN1(3), GRIN2A(7), GRIN2B(9), GRIN2C(2), GRIN2D(1), GRM1(11), GRM5(11), ITPR1(13), ITPR2(12), ITPR3(10), KRAS(7), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKCG(4), PRKX(1), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF3(2), RPS6KA1(2), RPS6KA2(6), RPS6KA6(6) 20639472 254 73 251 84 64 87 51 15 37 0 0.00019 0.0016 71 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(16), CR2(3), FCGR2B(1), HLA-DRA(2), HLA-DRB1(1), ICAM1(2), ITGAL(6), ITGB2(5), PTPRC(13) 3080014 50 31 47 15 14 11 11 6 4 4 0.00026 0.0023 72 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), AKT2(1), AKT3(3), CDKN1A(1), ELK1(2), GRB2(1), MAP2K1(3), MAP2K2(1), NGFR(2), NTRK1(3), PIK3CA(23), PIK3CD(6), SHC1(3), SOS1(3) 3343088 54 36 42 16 13 20 17 3 1 0 0.00031 0.0027 73 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(3), ACVR1B(4), ACVR1C(3), ACVR2A(16), ACVR2B(3), ACVRL1(2), AMH(1), AMHR2(3), BMP2(2), BMP4(5), BMP5(5), BMP6(4), BMP7(2), BMP8A(1), BMP8B(1), BMPR1A(1), BMPR1B(2), BMPR2(9), CHRD(1), COMP(1), CREBBP(11), CUL1(5), DCN(2), E2F5(1), EP300(10), FST(1), GDF5(1), GDF6(5), GDF7(1), IFNG(2), INHBA(4), INHBB(7), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(9), MAPK1(2), MAPK3(1), PITX2(2), PPP2CA(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(2), RBL1(3), RBL2(1), RHOA(4), ROCK1(5), ROCK2(2), RPS6KB1(2), RPS6KB2(2), SMAD1(1), SMAD2(7), SMAD3(2), SMAD4(5), SMAD5(1), SMAD6(2), SMAD7(1), SMAD9(4), SMURF1(1), SP1(2), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TGFBR2(4), THBS1(5), THBS2(6), THBS3(2), THBS4(2), TNF(1), ZFYVE16(5), ZFYVE9(2) 20249782 230 66 211 86 56 70 44 14 44 2 0.00035 0.0029 74 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), BAD(1), CASP9(1), CDC42(1), ELK1(2), MAP2K1(3), MAPK3(1), NFKB1(4), PIK3CA(23), PIK3R1(5), RAF1(6), RALBP1(7), RALGDS(6), RELA(2), RHOA(4) 3904614 68 37 55 16 15 18 22 6 7 0 0.00037 0.0031 75 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CDK5(2), CFL1(1), CHN1(3), LIMK1(2), MAP3K1(5), MYL2(1), MYLK(7), PAK1(2), PDGFRA(2), PIK3CA(23), PIK3R1(5), PLD1(6), PPP1R12B(2), RALBP1(7), RPS6KB1(2), TRIO(20), VAV1(2), WASF1(3) 7060704 95 49 82 40 30 24 24 5 10 2 0.00041 0.0033 76 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CHRNG(3), MUSK(3), PIK3CA(23), PIK3R1(5), PTK2(5), PTK2B(8), RAPSN(1), TERT(3) 3380062 54 34 42 20 16 14 17 1 6 0 0.00042 0.0034 77 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), BAD(1), GRB2(1), IGF1R(11), IRS1(5), MAP2K1(3), MAPK1(2), MAPK3(1), PIK3CA(23), PIK3R1(5), RAF1(6), SHC1(3), SOS1(3) 3799012 66 38 54 15 19 17 21 3 6 0 0.00052 0.0042 78 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(11), EP300(10), FYN(3), IL2RG(2), IL7R(3), JAK1(5), JAK3(3), LCK(1), NMI(1), PIK3CA(23), PIK3R1(5), PTK2B(8), STAT5B(4) 5698518 79 42 66 20 26 13 18 4 16 2 0.00060 0.0047 79 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(4), ELK1(2), GRB2(1), JUN(2), MAP2K1(3), MAPK3(1), MAPK8(4), NGFR(2), PIK3CA(23), PIK3R1(5), PLCG1(9), RAF1(6), SHC1(3), SOS1(3) 3871231 68 37 55 13 23 19 17 4 5 0 0.00068 0.0052 80 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(4), ELK1(2), GRB2(1), JAK1(5), JUN(2), MAP2K1(3), MAP2K4(5), MAP3K1(5), MAPK3(1), MAPK8(4), PDGFA(1), PDGFRA(2), PIK3CA(23), PIK3R1(5), PLCG1(9), RAF1(6), RASA1(10), SHC1(3), SOS1(3), SRF(1), STAT1(3), STAT3(4) 6989549 102 49 88 23 28 33 20 5 12 4 0.00068 0.0052 81 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(2), ALOX15(2), ALOX5(2), CBR1(1), CBR3(1), CYP4F2(1), CYP4F3(3), EPX(3), GGT1(7), LPO(2), LTA4H(4), MPO(5), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PRDX6(1), PTGES2(4), PTGIS(5), PTGS1(4), PTGS2(1), TBXAS1(2), TPO(12) 5668593 74 44 72 20 27 25 11 6 5 0 0.00072 0.0054 82 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(3), GRB2(1), ITGB1(2), MAPK1(2), MAPK3(1), PDPK1(1), PIK3CA(23), PIK3R1(5), PTEN(5), PTK2(5), SHC1(3), SOS1(3) 3959942 56 35 44 14 15 10 19 3 9 0 0.00073 0.0055 83 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(4), GRB2(1), MAPK1(2), MAPK3(1), MAPK7(8), MEF2B(2), MEF2C(1), MEF2D(3), NTRK1(3), PIK3CA(23), PIK3R1(5), PLCG1(9), RPS6KA1(2), SHC1(3) 3874556 69 38 56 14 22 23 17 1 6 0 0.00082 0.0061 84 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(3), CRK(1), CXCR4(2), GNAI1(1), GNAQ(1), GNB1(1), GNGT1(2), MAP2K1(3), MAPK1(2), MAPK3(1), NFKB1(4), PIK3C2G(3), PIK3CA(23), PIK3R1(5), PLCG1(9), PTK2(5), PTK2B(8), PXN(2), RAF1(6), RELA(2) 5742940 84 44 71 20 24 20 23 4 13 0 0.00084 0.0061 85 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(2), AKT2(1), AKT3(3), BCR(4), BTK(1), CDKN2A(2), FLOT1(1), FLOT2(3), ITPR1(13), ITPR2(12), ITPR3(10), LYN(2), NR0B2(1), PDK1(1), PHF11(2), PIK3CA(23), PITX2(2), PLCG2(5), PPP1R13B(3), PREX1(8), PTEN(5), PTPRC(13), RPS6KA1(2), RPS6KA2(6), RPS6KB1(2), SAG(1), SYK(1), TEC(3), VAV1(2) 11263637 134 57 122 54 39 43 30 7 15 0 0.0012 0.0085 86 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ARPC1A(1), ARPC1B(1), ARPC4(1), CDC42(1), PAK1(2), PDGFRA(2), PIK3CA(23), PIK3R1(5), WASL(1) 2678487 39 29 27 15 10 8 15 2 4 0 0.0012 0.0088 87 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(2), INPP4A(3), INPP4B(4), INPP5A(2), INPPL1(11), ITPKA(1), ITPKB(4), OCRL(3), PIK3C2A(4), PIK3C2B(9), PIK3C2G(3), PIK3CA(23), PIK3CB(4), PIK3CG(9), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PLCG1(9), PLCG2(5) 9204398 119 51 105 29 33 35 32 6 11 2 0.0013 0.0091 88 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 163 ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA1B(2), ADRA1D(1), ADRA2A(2), ADRA2C(3), ADRB1(2), ADRB2(2), ADRB3(1), AGTR1(1), AGTR2(1), AVPR1A(5), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(2), CCBP2(3), CCKAR(2), CCKBR(3), CCR1(1), CCR2(1), CCR3(3), CCR6(1), CCR8(1), CCR9(1), CCRL1(5), CHML(2), CHRM1(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(3), CMKLR1(1), CNR1(4), CX3CR1(4), CXCR4(2), DRD1(2), DRD2(5), DRD3(7), DRD5(8), EDNRA(2), EDNRB(10), F2R(2), F2RL1(3), FPR1(1), FSHR(11), GALR1(2), GALR3(1), GALT(1), GHSR(4), GPR173(1), GPR174(1), GPR27(2), GPR3(3), GPR35(3), GPR37(1), GPR37L1(2), GPR4(2), GPR44(2), GPR50(3), GPR6(5), GPR83(4), GPR85(1), GPR87(4), GRPR(3), HCRTR1(3), HCRTR2(2), HRH1(3), HRH2(2), HTR1A(5), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(3), HTR2A(1), HTR2B(4), HTR2C(2), HTR4(3), HTR5A(2), HTR7(3), LHCGR(5), LTB4R(2), MAS1(1), MC3R(3), MC4R(2), MC5R(6), MLNR(1), MTNR1A(2), MTNR1B(2), NMBR(1), NMUR1(1), NMUR2(1), NPY1R(2), NPY2R(1), NPY5R(1), NTSR1(1), OPN1SW(1), OPN3(2), OPRD1(1), OPRK1(3), OR10A5(1), OR11A1(3), OR1F1(1), OR1Q1(3), OR2H1(1), OR5V1(1), OR7A5(1), OR7C1(1), OR8B8(5), OXTR(3), P2RY1(3), P2RY10(1), P2RY12(8), P2RY13(4), P2RY14(2), PPYR1(5), PTAFR(2), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), RGR(2), RHO(1), RRH(2), SSTR1(4), SSTR3(3), SSTR4(6), SUCNR1(1), TBXA2R(6), TRHR(5) 24610719 347 82 341 103 94 122 77 23 31 0 0.0013 0.0092 89 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(2), AKT2(1), AKT3(3), BAD(1), CDC42(1), CDK2(2), CDKN2A(2), CREB1(4), CREB3(3), CREB5(2), EBP(1), ERBB4(12), GRB2(1), GSK3B(1), IGF1(2), IGFBP1(2), INPPL1(11), IRS1(5), IRS2(3), IRS4(9), MET(3), NOLC1(6), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PARD3(6), PDK1(1), PIK3CA(23), PIK3CD(6), PPP1R13B(3), PREX1(8), PTEN(5), PTK2(5), RPS6KA1(2), RPS6KA2(6), RPS6KB1(2), SHC1(3), SLC2A4(1), SOS1(3), SOS2(4), TSC1(1), TSC2(3), YWHAG(1), YWHAQ(2), YWHAZ(1) 15676843 176 66 162 60 48 51 45 9 23 0 0.0013 0.0093 90 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(8), BDKRB1(1), BDKRB2(2), C1QA(1), C1QC(2), C1R(6), C1S(3), C2(2), C3(11), C3AR1(2), C5(7), C5AR1(1), C6(7), C7(2), C8A(3), C8B(4), C9(3), CD46(1), CD55(1), CD59(1), CFB(3), CFH(9), CFI(2), CPB2(4), CR1(16), CR2(3), F10(3), F11(2), F12(2), F13A1(8), F13B(8), F2(4), F2R(2), F3(1), F5(8), F7(5), F8(9), F9(3), FGA(4), FGB(3), FGG(2), KLKB1(4), KNG1(2), MASP1(3), MASP2(2), MBL2(1), PLAT(2), PLAU(1), PLG(9), PROC(2), SERPINA1(3), SERPINA5(1), SERPINC1(2), SERPIND1(3), SERPINE1(1), SERPINF2(3), SERPING1(5), TFPI(2), THBD(1), VWF(8) 18373950 224 67 220 57 55 72 49 15 27 6 0.0014 0.0093 91 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(4), EPX(3), LPO(2), MPO(5), MTHFR(4), PRDX6(1), SHMT1(1), SHMT2(2), TPO(12) 2358622 35 25 35 8 14 12 3 1 5 0 0.0014 0.0097 92 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR1(1), AGTR2(1), ATP8A1(7), AVPR1A(5), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(2), CCKAR(2), CCKBR(3), CCR1(1), CCR2(1), CCR3(3), CCR6(1), CCR8(1), CX3CR1(4), CXCR4(2), EDNRA(2), EDNRB(10), FPR1(1), FSHR(11), GALR1(2), GALR3(1), GALT(1), GHSR(4), GNRHR(2), GRPR(3), LHCGR(5), MC2R(1), MC3R(3), MC4R(2), MC5R(6), NMBR(1), NPY1R(2), NPY2R(1), NPY5R(1), NTSR1(1), OPRD1(1), OPRK1(3), OXTR(3), PPYR1(5), SSTR1(4), SSTR3(3), SSTR4(6), TAC4(1), TACR1(2), TACR2(1), TACR3(4), TRHR(5), TSHR(5) 10347932 142 56 139 41 27 55 30 17 13 0 0.0016 0.011 93 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(2), AKT2(1), AKT3(3), BRD4(4), CBL(1), CDC42(1), CDKN2A(2), FLOT1(1), FLOT2(3), GRB2(1), GSK3B(1), IGFBP1(2), INPPL1(11), IRS1(5), IRS2(3), IRS4(9), LNPEP(9), MAPK1(2), MAPK3(1), PARD3(6), PDK1(1), PIK3CA(23), PIK3CD(6), PIK3R1(5), PPYR1(5), PTEN(5), RAF1(6), RPS6KA1(2), RPS6KA2(6), RPS6KB1(2), SERPINB6(2), SHC1(3), SLC2A4(1), SORBS1(5), SOS1(3), SOS2(4), YWHAG(1), YWHAQ(2), YWHAZ(1) 12043948 151 59 138 47 44 50 32 6 19 0 0.0017 0.011 94 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), BAD(1), CASP9(1), GH1(1), GHR(5), NFKB1(4), PDPK1(1), PIK3CA(23), PIK3R1(5), PPP2CA(1), RELA(2) 2871603 46 30 34 10 13 7 18 3 5 0 0.0017 0.011 95 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), GRB2(1), NTRK1(3), PIK3CA(23), PIK3R1(5), PLCG1(9), SHC1(3), SOS1(3) 3147179 49 32 36 11 17 10 16 2 4 0 0.0018 0.011 96 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B1(3), EIF2B3(3), EIF2B4(5), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF2S3(1), ELAVL1(3), FLT1(5), FLT4(6), HIF1A(1), KDR(7), NOS3(2), PIK3CA(23), PIK3R1(5), PLCG1(9), PTK2(5), PXN(2), SHC1(3) 6926640 89 47 75 23 31 21 24 6 7 0 0.0019 0.012 97 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(1), ABLIM1(2), ABLIM2(3), ABLIM3(4), ARHGEF12(5), CDC42(1), CDK5(2), CFL1(1), CXCR4(2), DCC(17), DPYSL2(1), DPYSL5(4), EFNA2(2), EFNA5(1), EFNB1(1), EFNB2(3), EFNB3(4), EPHA1(6), EPHA2(3), EPHA3(10), EPHA4(5), EPHA5(10), EPHA6(9), EPHA7(2), EPHA8(7), EPHB1(9), EPHB2(10), EPHB3(4), EPHB4(4), EPHB6(6), FES(4), FYN(3), GNAI1(1), GNAI2(3), GNAI3(3), GSK3B(1), ITGB1(2), KRAS(7), L1CAM(3), LIMK1(2), LIMK2(3), LRRC4C(3), MAPK1(2), MAPK3(1), MET(3), NCK1(2), NCK2(2), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), NGEF(4), NRP1(8), NTN1(2), NTN4(1), NTNG1(3), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PLXNA1(10), PLXNA2(12), PLXNA3(5), PLXNB1(5), PLXNB3(4), PLXNC1(5), PPP3CA(2), PPP3CB(1), PPP3R2(1), PTK2(5), RAC2(1), RASA1(10), RGS3(7), RHOA(4), ROBO1(11), ROBO2(9), ROBO3(6), ROCK1(5), ROCK2(2), SEMA3A(3), SEMA3D(5), SEMA3E(6), SEMA3F(7), SEMA3G(3), SEMA4A(3), SEMA4B(2), SEMA4C(5), SEMA4D(3), SEMA4F(3), SEMA5A(10), SEMA5B(4), SEMA6A(4), SEMA6B(2), SEMA6C(3), SEMA6D(6), SEMA7A(2), SLIT1(3), SLIT2(13), SLIT3(8), SRGAP1(7), SRGAP2(5), SRGAP3(4), UNC5A(5), UNC5B(3), UNC5C(8), UNC5D(5) 40504219 474 93 465 182 115 150 119 34 54 2 0.0020 0.013 98 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 81 ANPEP(3), CD14(1), CD1A(1), CD1B(2), CD1D(4), CD1E(4), CD2(2), CD33(2), CD34(2), CD36(1), CD37(1), CD38(2), CD3E(1), CD3G(2), CD4(3), CD44(3), CD5(4), CD55(1), CD59(1), CD8A(1), CR1(16), CR2(3), CSF1R(7), CSF3(1), CSF3R(3), EPOR(2), FCER2(1), FLT3(4), GP1BA(1), GP5(2), GYPA(1), HLA-DRA(2), HLA-DRB1(1), IL11(1), IL11RA(1), IL1B(1), IL1R1(2), IL2RA(1), IL3(1), IL6(1), IL7R(3), ITGA1(4), ITGA2(3), ITGA2B(5), ITGA3(6), ITGA4(7), ITGA5(4), ITGA6(2), ITGAM(4), ITGB3(5), KIT(5), KITLG(3), MME(2), TFRC(1), THPO(2), TNF(1), TPO(12) 16348094 162 62 158 70 41 46 34 14 23 4 0.0020 0.013 99 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(6), GABBR1(7), GPRC5B(1), GPRC5C(2), GRM1(11), GRM2(8), GRM3(3), GRM4(3), GRM5(11), GRM7(6), GRM8(8) 4204662 66 39 66 25 19 27 14 2 4 0 0.0020 0.013 100 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(1), ABL2(2), AKT1(2), AKT2(1), AKT3(3), ARAF(6), BAD(1), BRAF(5), BTC(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CBL(1), CBLB(2), CBLC(2), CDKN1A(1), CRK(1), EGF(4), EGFR(7), EIF4EBP1(1), ELK1(2), ERBB2(4), ERBB3(12), ERBB4(12), EREG(2), GRB2(1), GSK3B(1), JUN(2), KRAS(7), MAP2K1(3), MAP2K2(1), MAP2K4(5), MAP2K7(8), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(1), NCK1(2), NCK2(2), NRG1(8), NRG2(4), NRG3(8), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLCG1(9), PLCG2(5), PRKCG(4), PTK2(5), RAF1(6), RPS6KB1(2), RPS6KB2(2), SHC1(3), SHC2(2), SHC3(3), SHC4(1), SOS1(3), SOS2(4), STAT5B(4), TGFA(2) 21047915 265 71 247 88 67 89 68 11 30 0 0.0021 0.013 101 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(12), NRG2(4), NRG3(8), PSEN1(1) 1806539 26 22 25 5 4 5 14 1 2 0 0.0022 0.013 102 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), ASIP(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CREB1(4), CREB3(3), CREB3L1(2), CREB3L2(1), CREB3L3(3), CREB3L4(1), CREBBP(11), CTNNB1(8), DCT(5), DVL1(3), DVL2(2), DVL3(3), EDN1(2), EDNRB(10), EP300(10), FZD1(7), FZD10(7), FZD2(1), FZD3(1), FZD6(7), FZD7(2), FZD8(3), GNAI1(1), GNAI2(3), GNAI3(3), GNAQ(1), GNAS(12), GSK3B(1), KIT(5), KITLG(3), KRAS(7), LEF1(3), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), MITF(5), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), POMC(5), PRKACA(1), PRKACB(2), PRKACG(2), PRKCG(4), PRKX(1), RAF1(6), TCF7(1), TCF7L1(3), TCF7L2(3), TYR(1), TYRP1(4), WNT1(3), WNT10A(3), WNT10B(1), WNT16(2), WNT2(2), WNT2B(5), WNT3(3), WNT3A(1), WNT5A(2), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1), WNT9A(2) 22337350 296 73 288 120 81 106 59 15 35 0 0.0022 0.013 103 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 125 ARAF(6), BID(1), BRAF(5), CASP3(1), CD244(1), CD247(2), FAS(1), FCGR3A(1), FCGR3B(1), FYN(3), GRB2(1), HLA-A(8), HLA-B(10), HLA-C(4), HLA-E(3), ICAM1(2), ICAM2(2), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(1), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), ITGAL(6), ITGB2(5), KIR2DL1(3), KIR2DL3(1), KIR2DL4(3), KIR3DL1(1), KLRC1(1), KLRC2(1), KLRD1(1), KRAS(7), LCK(1), LCP2(6), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), MICB(1), NCR1(1), NCR2(2), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), PAK1(2), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLCG1(9), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRF1(1), PRKCG(4), PTK2B(8), PTPN11(3), RAC2(1), RAF1(6), SH2D1A(1), SH2D1B(1), SH3BP2(2), SHC1(3), SHC2(2), SHC3(3), SHC4(1), SOS1(3), SOS2(4), SYK(1), TNF(1), TNFRSF10A(2), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(2), TNFSF10(2), ULBP1(2), VAV1(2), VAV2(5), VAV3(6), ZAP70(3) 23019640 291 69 274 81 76 82 74 17 40 2 0.0023 0.014 104 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(9), AKT1(2), CAMK2A(1), CAMK2B(2), CAMK2G(3), CREB1(4), GNAS(12), GRB2(1), MAPK1(2), MAPK14(1), MAPK3(1), PIK3CA(23), PIK3R1(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RPS6KA1(2), SOS1(3) 5841094 83 45 70 24 24 25 20 5 9 0 0.0023 0.014 105 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(5), AR(6), ESR1(4), ESR2(5), HNF4A(4), NR0B1(2), NR1D1(1), NR1D2(3), NR1H2(3), NR1I2(2), NR2C2(3), NR2F1(3), NR2F2(2), NR2F6(1), NR3C1(3), NR4A1(1), NR4A2(4), NR5A1(4), PGR(5), PPARA(2), PPARD(4), PPARG(1), RARA(1), RARB(5), ROR1(5), RORA(2), RORC(3), RXRA(2), RXRG(2), THRA(1), THRB(4), VDR(5) 8609489 98 52 97 38 21 37 23 6 11 0 0.0025 0.015 106 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), CHST1(8), CHST2(6), CHST6(4), FUT8(2), ST3GAL1(3), ST3GAL2(3), ST3GAL3(2), ST3GAL4(1) 2560782 45 32 44 21 14 19 9 1 2 0 0.0025 0.015 107 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(4), GRB2(1), JAK2(4), JUN(2), MAP2K1(3), MAPK3(1), PIK3CA(23), PIK3R1(5), PLCG1(9), RAF1(6), RASA1(10), SHC1(3), SOS1(3), STAT1(3), STAT3(4), STAT5B(4), THPO(2) 6030220 87 42 73 14 24 26 20 4 11 2 0.0026 0.015 108 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), DCN(2), FMOD(6), KERA(1), LUM(2) 722988 13 13 13 2 3 7 1 2 0 0 0.0027 0.015 109 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(1), GGT1(7), SHMT1(1), SHMT2(2) 882588 11 11 10 4 3 2 1 3 2 0 0.0028 0.016 110 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(2), AKT2(1), AKT3(3), BCL10(1), CARD11(7), CBL(1), CBLB(2), CBLC(2), CD247(2), CD3E(1), CD3G(2), CD4(3), CD40LG(3), CD8A(1), CDC42(1), CTLA4(2), FYN(3), GRAP2(1), GRB2(1), ICOS(1), IFNG(2), IKBKB(3), IL10(1), IL2(1), ITK(2), JUN(2), KRAS(7), LCK(1), LCP2(6), MALT1(2), MAP3K14(1), NCK1(2), NCK2(2), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), NFKB1(4), NFKB2(2), NFKBIB(3), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PDK1(1), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLCG1(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKCQ(1), PTPRC(13), RASGRP1(3), RHOA(4), SOS1(3), SOS2(4), TEC(3), TNF(1), VAV1(2), VAV2(5), VAV3(6), ZAP70(3) 20667402 233 72 215 87 63 69 59 17 25 0 0.0031 0.018 111 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(18), AR(6), ASAH1(1), BRAF(5), DAG1(7), EGFR(7), GNA11(1), GNA15(2), GNAI1(1), GNAQ(1), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), KCNJ3(3), MAPK1(2), MAPK10(3), MAPK14(1), PHKA2(4), PIK3CA(23), PIK3CD(6), PIK3R1(5), PITX2(2), PTX3(1), RAF1(6) 10932334 147 54 134 48 35 47 38 6 17 4 0.0032 0.018 112 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CDK2(2), CDK6(4), CDKN1A(1), MAPK1(2), MAPK3(1), NFKB1(4), PAK1(2), PIK3CA(23), PIK3R1(5), RAF1(6), RB1(6), RELA(2) 4131246 60 36 47 15 15 13 20 4 8 0 0.0032 0.018 113 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A1(2), EIF4A2(3), EIF4B(2), EIF4E(1), EIF4EBP1(1), EIF4G1(7), EIF4G2(1), EIF4G3(5), MKNK1(1), PDPK1(1), PIK3CA(23), PIK3R1(5), PPP2CA(1), PTEN(5), RPS6(1), RPS6KB1(2), TSC1(1), TSC2(3) 5599167 67 40 55 29 15 21 20 4 7 0 0.0033 0.018 114 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(2), GBA3(1), GGT1(7), SHMT1(1), SHMT2(2) 1172794 14 14 13 5 4 3 1 4 2 0 0.0034 0.018 115 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6) 1121589 22 17 21 3 1 5 5 6 5 0 0.0034 0.018 116 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(9), CD3E(1), CD3G(2), CD4(3), CREBBP(11), CSK(2), GNAS(12), GNB1(1), GNGT1(2), HLA-DRA(2), HLA-DRB1(1), LCK(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PTPRC(13), ZAP70(3) 4621883 75 38 73 31 20 24 11 8 12 0 0.0037 0.019 117 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(9), CD3E(1), CD3G(2), CD4(3), CREBBP(11), CSK(2), GNAS(12), GNB1(1), GNGT1(2), HLA-DRA(2), HLA-DRB1(1), LCK(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PTPRC(13), ZAP70(3) 4621883 75 38 73 31 20 24 11 8 12 0 0.0037 0.019 118 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(4), F13A1(8), F2(4), F2R(2), FGA(4), FGB(3), FGG(2), PLAT(2), PLAU(1), PLG(9), SERPINB2(2), SERPINE1(1) 2669842 42 29 42 8 11 11 10 2 8 0 0.0037 0.019 119 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(3), GNAS(12), GNB1(1), GNGT1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5) 1893654 30 24 29 7 6 17 1 3 3 0 0.0039 0.020 120 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(3), ACVR1B(4), ACVRL1(2), AKT1(2), AURKB(2), BMPR1A(1), BMPR2(9), BUB1(6), CDKL1(2), CDKL2(3), CDS1(2), CDS2(1), CLK1(3), CLK2(2), CLK4(2), COL4A3BP(1), CSNK2A1(4), CSNK2A2(1), DGKA(1), DGKB(3), DGKE(1), DGKH(8), DGKQ(2), DGKZ(1), IMPA1(2), INPP4A(3), INPP4B(4), INPP5A(2), INPPL1(11), ITPKA(1), ITPKB(4), MAP3K10(5), MOS(3), NEK1(4), OCRL(3), PAK4(2), PIK3C2A(4), PIK3C2B(9), PIK3C2G(3), PIK3CA(23), PIK3CB(4), PIK3CG(9), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PLCG1(9), PLCG2(5), PLK3(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PRKCD(2), PRKCE(3), PRKCG(4), PRKCH(2), PRKCQ(1), PRKD1(5), PRKG1(4), RAF1(6), RPS6KA1(2), RPS6KA2(6), RPS6KA4(2), RPS6KB1(2), TGFBR1(1), VRK1(2) 23285906 257 72 241 75 67 82 57 17 30 4 0.0040 0.021 121 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), CREB1(4), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAP3K1(5), MAPK1(2), MAPK14(1), MAPK3(1), NFKB1(4), PIK3CA(23), PIK3R1(5), RB1(6), RELA(2), SP1(2) 3950233 64 36 51 12 15 13 23 5 8 0 0.0050 0.025 122 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(3), GBA(2), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(12) 1720621 26 21 26 8 13 8 1 2 2 0 0.0052 0.026 123 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), GORASP1(2), MAP2K4(5), MAP2K7(8), MAPK1(2), MAPK10(3), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK8IP1(1), MAPK8IP3(7), MAPK9(1), MAPKAPK5(1), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), PIK3CA(23), PIK3CD(6), PIK3R1(5), TRAF2(2), TRAF3(2), TRAF6(3) 6990480 94 46 82 22 27 32 19 3 13 0 0.0057 0.029 124 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(4), EPX(3), LPO(2), MPO(5), PRDX6(1), SHMT1(1), SHMT2(2), TPO(12) 2401714 31 24 31 9 14 10 2 0 5 0 0.0059 0.029 125 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), AKAP1(1), AKAP10(1), AKAP11(3), AKAP12(3), AKAP3(2), AKAP6(8), AKAP7(6), AKAP8(5), AKAP9(13), ARHGEF1(1), CALM1(1), CALM2(2), CALM3(1), CHMP1B(1), GNA11(1), GNA12(1), GNA14(1), GNA15(2), GNAI2(3), GNAI3(3), GNAQ(1), GNAZ(5), GNB1(1), GNB2(3), GNB3(1), GNG12(1), GNG7(2), GNGT1(2), GNGT2(1), ITPR1(13), KCNJ3(3), KRAS(7), PDE1A(2), PDE1B(1), PDE1C(2), PDE4A(4), PDE4B(4), PDE4C(2), PDE7A(5), PDE7B(2), PDE8A(5), PDE8B(2), PLCB3(6), PPP3CA(2), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PRKCD(2), PRKCE(3), PRKCG(4), PRKCH(2), PRKCI(4), PRKCQ(1), PRKD1(5), PRKD3(1), RHOA(4), RRAS(1), SLC9A1(4), USP5(3) 23738106 235 68 226 88 62 67 58 17 31 0 0.0059 0.029 126 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(6), DIAPH1(3), FYN(3), GSN(4), ITGA1(4), ITGB1(2), MAP2K1(3), MAPK1(2), MAPK3(1), MYL2(1), MYLK(7), PIK3CA(23), PIK3R1(5), PTK2(5), PXN(2), RAF1(6), ROCK1(5), SHC1(3), TLN1(9) 7567168 94 46 82 27 28 22 23 6 13 2 0.0065 0.032 127 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), AGT(1), AKT1(2), CALM1(1), CALM2(2), CALM3(1), CALR(4), CAMK1(1), CAMK1G(3), CAMK4(2), CREBBP(11), EDN1(2), F2(4), FGF2(1), GATA4(2), GSK3B(1), HAND1(2), HAND2(3), IGF1(2), LIF(2), MAP2K1(3), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), MEF2C(1), MYH2(9), NFATC2(5), NFATC3(3), NFATC4(9), NKX2-5(2), PIK3CA(23), PIK3R1(5), PPP3CA(2), PPP3CB(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RAF1(6), RPS6KB1(2) 10185539 139 57 127 44 44 40 30 8 17 0 0.0066 0.032 128 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(2), GAD1(3), GAD2(3), GGT1(7) 1179045 16 16 15 3 4 8 1 3 0 0 0.0066 0.032 129 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(2), CD3E(1), CD3G(2), CD4(3), CD58(1), CD8A(1), CSF3(1), IL3(1), IL6(1), IL8(1), KITLG(3) 1271081 19 17 18 8 4 6 4 1 4 0 0.0069 0.033 130 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT1(2), AKT2(1), AKT3(3), BAD(1), BTK(1), CDKN2A(2), GRB2(1), GSK3B(1), IARS(6), IGFBP1(2), INPP5D(1), PDK1(1), PIK3CA(23), PPP1R13B(3), PTEN(5), RPS6KA1(2), RPS6KA2(6), RPS6KB1(2), SHC1(3), SOS1(3), SOS2(4), TEC(3), YWHAG(1), YWHAQ(2), YWHAZ(1) 7278824 80 45 68 30 26 21 20 3 10 0 0.0079 0.037 131 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ABP1(6), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH3A1(4), ALDH3B2(3), AOC2(4), AOC3(2), AOX1(3), COMT(1), DBH(2), DCT(5), DDC(3), FAH(2), GOT1(2), GOT2(2), GSTZ1(1), HPD(1), MAOA(1), MAOB(2), PNMT(2), TAT(1), TH(1), TPO(12), TYR(1) 6224932 83 42 82 19 18 33 9 10 9 4 0.0080 0.038 132 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(2), AKT2(1), AKT3(3), BTK(1), FYN(3), GRB2(1), IL13(1), IL3(1), INPP5D(1), KRAS(7), LCP2(6), LYN(2), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(8), MAPK1(2), MAPK10(3), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK9(1), PDK1(1), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLCG1(9), PLCG2(5), PRKCD(2), PRKCE(3), RAC2(1), RAF1(6), SOS1(3), SOS2(4), SYK(1), TNF(1), VAV1(2), VAV2(5), VAV3(6) 14666841 182 62 167 59 51 60 43 14 14 0 0.0087 0.041 133 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(3), CSF3(1), HLA-DRA(2), HLA-DRB1(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL11(1), IL12B(1), IL13(1), IL2(1), IL3(1), IL6(1), IL8(1), LTA(1), PDGFA(1), TGFB1(2), TGFB2(4), TGFB3(3), TNF(1) 2687531 32 25 32 14 4 12 11 3 2 0 0.0089 0.041 134 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3E(1), CD3G(2), HLA-A(8), ICAM1(2), ITGAL(6), ITGB2(5), PRF1(1) 1749216 27 21 26 8 5 8 4 3 7 0 0.010 0.047 135 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), AKT1(2), ANGPTL2(3), DAG1(7), DGKA(1), ETFA(1), GCA(2), ITGA9(6), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), MAP2K1(3), MAPK1(2), MAPK3(1), PAK1(2), PDE3A(3), PDE3B(9), PI3(2), PIK3C2G(3), PIK3CA(23), PIK3CD(6), PIK3R1(5), RIPK3(2), VASP(2) 10035781 127 53 115 41 23 45 33 8 16 2 0.010 0.047 136 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTB(3), ACTN1(2), ACTN2(11), ACTN3(1), ACTN4(1), AKT1(2), AKT2(1), AKT3(3), AMOTL1(4), ASH1L(16), CASK(3), CDC42(1), CGN(5), CLDN1(1), CLDN10(1), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(1), CLDN23(3), CLDN4(2), CLDN6(1), CLDN9(2), CSDA(4), CSNK2A1(4), CSNK2A2(1), CTNNA1(3), CTNNA2(9), CTNNA3(5), CTNNB1(8), CTTN(1), EPB41(7), EPB41L1(2), EPB41L2(7), EPB41L3(9), EXOC3(4), EXOC4(1), GNAI1(1), GNAI2(3), GNAI3(3), HCLS1(1), IGSF5(1), INADL(4), JAM3(2), KRAS(7), LLGL1(4), LLGL2(3), MAGI1(11), MAGI2(7), MAGI3(4), MLLT4(12), MPDZ(12), MPP5(1), MYH1(6), MYH10(13), MYH11(11), MYH13(10), MYH14(8), MYH15(6), MYH2(9), MYH3(13), MYH4(9), MYH6(7), MYH7(11), MYH7B(10), MYH8(7), MYH9(13), MYL2(1), PARD3(6), PARD6B(1), PARD6G(2), PPM1J(3), PPP2CA(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(1), PPP2R2B(2), PPP2R2C(2), PPP2R3A(3), PPP2R4(1), PRKCD(2), PRKCE(3), PRKCG(4), PRKCH(2), PRKCI(4), PRKCQ(1), PTEN(5), RAB3B(3), RHOA(4), RRAS(1), RRAS2(1), SPTAN1(8), SYMPK(4), TJAP1(2), TJP1(4), TJP2(5), TJP3(4), YES1(2), ZAK(2) 39463361 440 84 434 134 101 173 78 38 48 2 0.010 0.047 137 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(2), ACTN2(11), ACTN3(1), ACTN4(1), ARHGAP5(6), BCAR1(3), CDC42(1), CDH5(2), CLDN1(1), CLDN10(1), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(1), CLDN23(3), CLDN4(2), CLDN6(1), CLDN9(2), CTNNA1(3), CTNNA2(9), CTNNA3(5), CTNNB1(8), CTNND1(5), CXCR4(2), CYBA(1), CYBB(2), ESAM(4), GNAI1(1), GNAI2(3), GNAI3(3), GRLF1(8), ICAM1(2), ITGA4(7), ITGAL(6), ITGAM(4), ITGB1(2), ITGB2(5), ITK(2), JAM3(2), MAPK13(1), MAPK14(1), MLLT4(12), MMP2(3), MMP9(5), MSN(3), MYL2(1), NCF1(1), NCF4(1), NOX1(4), NOX3(3), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLCG1(9), PLCG2(5), PRKCG(4), PTK2(5), PTK2B(8), PTPN11(3), PXN(2), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF3(2), RAPGEF4(3), RASSF5(1), RHOA(4), RHOH(1), ROCK1(5), ROCK2(2), TXK(1), VASP(2), VAV1(2), VAV2(5), VAV3(6), VCAM1(4), VCL(2) 25622317 304 76 288 123 76 107 66 19 34 2 0.013 0.059 138 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA1(2), INPP4A(3), INPP4B(4), INPP5A(2), INPP5B(2), INPP5E(2), INPPL1(11), IPMK(1), ISYNA1(2), ITGB1BP3(3), ITPK1(1), ITPKA(1), ITPKB(4), MINPP1(3), OCRL(3), PI4KA(6), PI4KB(4), PIK3C3(4), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIP4K2A(3), PIP4K2B(2), PIP4K2C(1), PIP5K1A(2), PIP5K1C(5), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PLCD3(5), PLCE1(7), PLCG1(9), PLCG2(5), PLCZ1(2), PTEN(5), PTPMT1(1), SYNJ1(5), SYNJ2(13) 15216796 188 60 172 51 50 65 42 9 20 2 0.015 0.067 139 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(3), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(12), TYR(1) 1969331 25 21 25 8 13 8 1 1 2 0 0.015 0.067 140 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), CALM2(2), CALM3(1), CD3E(1), CD3G(2), ELK1(2), FYN(3), GRB2(1), JUN(2), LCK(1), MAP2K1(3), MAP2K4(5), MAP3K1(5), MAPK3(1), MAPK8(4), NFATC2(5), NFATC3(3), NFATC4(9), NFKB1(4), PIK3CA(23), PIK3R1(5), PLCG1(9), PPP3CA(2), PPP3CB(1), PTPN7(2), RAF1(6), RASA1(10), RELA(2), SHC1(3), SOS1(3), VAV1(2), ZAP70(3) 9684927 126 51 111 27 37 32 28 6 21 2 0.017 0.073 141 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ABP1(6), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH3A1(4), ALDH3B2(3), AOC2(4), AOC3(2), AOX1(3), CARM1(1), COMT(1), DBH(2), DCT(5), DDC(3), ESCO2(1), FAH(2), GOT1(2), GOT2(2), GSTZ1(1), HPD(1), LCMT1(1), LCMT2(4), MAOA(1), MAOB(2), METTL6(1), MYST3(6), MYST4(12), NAT6(1), PNMT(2), PNPLA3(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), SH3GLB1(1), TAT(1), TH(1), TPO(12), TYR(1), TYRP1(4), WBSCR22(1) 11825828 127 52 126 29 29 45 19 13 17 4 0.017 0.074 142 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCR(4), GRB2(1), JAK2(4), JUN(2), MAP2K1(3), MAP2K4(5), MAP3K1(5), MAPK3(1), MAPK8(4), PIK3CA(23), PIK3R1(5), RAF1(6), SOS1(3), STAT1(3), STAT5B(4) 5651835 75 41 63 21 19 24 18 3 11 0 0.017 0.075 143 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(5), GABRA2(4), GABRA3(3), GABRA4(2), GABRA5(4), GABRA6(5), GPX1(1), PRKCE(3) 1592808 27 18 27 7 3 9 10 4 1 0 0.019 0.082 144 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(6), ALDH3A1(4), ALDH3B2(3), AOC2(4), AOC3(2), DDC(3), EPX(3), ESCO2(1), GOT1(2), GOT2(2), HPD(1), LPO(2), MAOA(1), MAOB(2), MPO(5), MYST3(6), MYST4(12), NAT6(1), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(1), TPO(12) 6891129 76 43 76 18 22 27 12 6 7 2 0.020 0.083 145 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(1), CD3G(2), CD4(3), FYN(3), HLA-DRA(2), HLA-DRB1(1), LCK(1), PTPRC(13), ZAP70(3) 1841119 29 21 28 15 8 6 6 5 4 0 0.020 0.083 146 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 ACTB(3), CHAD(3), COL11A1(12), COL11A2(5), COL17A1(4), COL1A1(6), COL1A2(13), COL2A1(7), COL3A1(6), COL4A1(5), COL4A2(4), COL4A4(4), COL4A6(5), COL5A1(7), COL5A2(4), COL5A3(5), COL6A3(15), COL6A6(15), COMP(1), DES(1), DSC1(2), DSC2(3), DSC3(3), DSG1(3), DSG3(4), DSG4(3), FN1(15), GJA1(7), GJA10(2), GJA3(1), GJA4(4), GJA8(1), GJA9(1), GJB3(2), GJB6(2), GJC2(2), GJD2(1), GJD4(4), IBSP(1), INA(3), ITGA6(2), ITGB4(10), KRT1(1), KRT10(1), KRT12(4), KRT13(5), KRT14(2), KRT15(1), KRT16(2), KRT17(1), KRT18(3), KRT2(6), KRT20(2), KRT23(1), KRT25(2), KRT27(3), KRT28(3), KRT3(1), KRT31(3), KRT32(1), KRT33A(5), KRT33B(4), KRT34(1), KRT35(2), KRT36(3), KRT37(3), KRT38(1), KRT5(3), KRT6A(3), KRT6B(1), KRT6C(2), KRT7(2), KRT71(1), KRT72(5), KRT73(3), KRT74(3), KRT76(2), KRT77(1), KRT78(2), KRT79(1), KRT81(1), KRT82(1), KRT83(2), KRT84(3), KRT85(2), KRT86(1), LAMA1(14), LAMA2(11), LAMA3(8), LAMA4(7), LAMA5(13), LAMB1(5), LAMB2(10), LAMB3(11), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(9), LMNA(2), LMNB1(1), LMNB2(3), NES(2), PRPH(1), RELN(15), THBS1(5), THBS2(6), THBS3(2), THBS4(2), TNC(11), TNN(10), TNR(9), TNXB(20), VIM(1), VTN(4), VWF(8) 50662892 508 84 506 233 142 192 84 37 53 0 0.020 0.083 147 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), ASAH1(1), BRAF(5), CREB1(4), CREB3(3), CREB5(2), CREBBP(11), DAG1(7), EGR1(3), EGR2(3), EGR3(1), EGR4(3), ELK1(2), FRS2(1), GNAQ(1), JUN(2), MAP1B(5), MAP2K4(5), MAP2K7(8), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK8IP1(1), MAPK8IP3(7), MAPK9(1), NTRK1(3), OPN1LW(3), PIK3C2G(3), PIK3CA(23), PIK3CD(6), PIK3R1(5), PTPN11(3), SHC1(3), TERF2IP(3), TH(1) 10657157 141 52 129 51 36 56 23 5 21 0 0.020 0.083 148 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), CALM1(1), CALM2(2), CALM3(1), ELK1(2), GRB2(1), JUN(2), LYN(2), MAP2K1(3), MAP2K4(5), MAP2K7(8), MAP3K1(5), MAPK1(2), MAPK3(1), MAPK8(4), NFATC2(5), NFATC3(3), NFATC4(9), PAK2(3), PIK3CA(23), PIK3R1(5), PLA2G4A(3), PLCG1(9), PPP3CA(2), PPP3CB(1), RAF1(6), SHC1(3), SOS1(3), SYK(1), VAV1(2) 8692614 118 50 105 25 34 37 29 3 15 0 0.022 0.092 149 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), GNAQ(1), GNB1(1), GNGT1(2), HTR2C(2), PLCB1(8), TUB(3) 1437863 18 16 18 8 3 7 3 0 5 0 0.023 0.094 150 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(1), CALM2(2), CALM3(1), CDS1(2), CDS2(1), DGKA(1), DGKB(3), DGKE(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), IMPA1(2), INPP4A(3), INPP4B(4), INPP5A(2), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(11), ITGB1BP3(3), ITPK1(1), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), OCRL(3), PI4KA(6), PI4KB(4), PIK3C2A(4), PIK3C2B(9), PIK3C2G(3), PIK3C3(4), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PIP4K2A(3), PIP4K2B(2), PIP4K2C(1), PIP5K1A(2), PIP5K1C(5), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), PLCD3(5), PLCE1(7), PLCG1(9), PLCG2(5), PLCZ1(2), PRKCG(4), PTEN(5), PTPMT1(1), SYNJ1(5), SYNJ2(13) 25712092 279 71 262 88 70 96 62 15 34 2 0.024 0.098 151 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), AVP(3), CABIN1(7), CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), HDAC5(3), IGF1(2), IGF1R(11), INSR(7), MAP2K6(2), MAPK14(1), MAPK7(8), MEF2B(2), MEF2C(1), MEF2D(3), MYOD1(3), NFATC2(5), PIK3CA(23), PIK3R1(5), PPP3CA(2), PPP3CB(1) 7104195 99 47 87 22 28 34 23 6 8 0 0.026 0.10 152 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL5(1), CCR3(3), HLA-DRA(2), HLA-DRB1(1), IL3(1) 610736 8 8 8 3 2 3 1 1 1 0 0.026 0.11 153 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(2), AKT2(1), AKT3(3), BCL10(1), BLNK(1), BTK(1), CARD11(7), CD79A(5), CD81(2), CR2(3), FCGR2B(1), GSK3B(1), IFITM1(1), IKBKB(3), INPP5D(1), JUN(2), KRAS(7), LILRB3(2), LYN(2), MALT1(2), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), NFKB1(4), NFKB2(2), NFKBIB(3), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3R2(1), RAC2(1), RASGRP3(1), SYK(1), VAV1(2), VAV2(5), VAV3(6) 15141518 159 57 143 66 45 49 39 8 18 0 0.027 0.11 154 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(4), GABRA1(5), GABRA2(4), GABRA3(3), GABRA4(2), GABRA5(4), GABRA6(5), GPHN(3), NSF(2), UBQLN1(1) 2412886 33 22 33 10 2 10 12 4 5 0 0.027 0.11 155 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT1(2), AKT2(1), AKT3(3), CASP8(3), CCL5(1), CD14(1), CD40(1), CD80(1), CD86(2), CXCL9(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(1), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IKBKB(3), IKBKE(2), IL12B(1), IL1B(1), IL6(1), IL8(1), IRAK1(4), IRAK4(1), IRF3(3), IRF5(1), IRF7(1), JUN(2), LY96(1), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(8), MAP3K7(7), MAPK1(2), MAPK10(3), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK9(1), MYD88(2), NFKB1(4), NFKB2(2), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), RELA(2), STAT1(3), TICAM1(3), TIRAP(1), TLR1(5), TLR2(2), TLR3(1), TLR4(9), TLR5(1), TLR7(3), TLR8(6), TLR9(7), TNF(1), TOLLIP(1), TRAF3(2), TRAF6(3) 18254250 210 66 194 63 40 73 58 12 27 0 0.028 0.11 156 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(7), ERBB3(12), NRG1(8) 2063894 31 22 31 13 11 9 6 1 4 0 0.029 0.11 157 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(3), MBTPS1(9), SCAP(7), SREBF1(3), SREBF2(5) 2488962 28 22 28 14 5 10 8 3 2 0 0.030 0.12 158 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), AKT1(2), AKT2(1), AKT3(3), ANGPTL2(3), ARHGAP4(1), ARHGEF11(8), BTK(1), CDC42(1), CFL1(1), GDI1(1), INPPL1(11), ITPR1(13), ITPR2(12), ITPR3(10), LIMK1(2), MYLK(7), MYLK2(2), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PDK1(1), PIK3CA(23), PIK3CD(6), PIK3CG(9), PIK3R1(5), PITX2(2), PPP1R13B(3), PTEN(5), RACGAP1(2), RHO(1), ROCK1(5), ROCK2(2), SAG(1), WASF1(3), WASL(1) 14361473 163 56 150 56 47 51 38 9 18 0 0.032 0.12 159 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(2), NAT1(1), NAT2(5), XDH(8) 1592675 25 19 24 7 9 7 7 2 0 0 0.032 0.12 160 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 146 AKT1(2), AKT2(1), AKT3(3), CBL(1), CBLB(2), CBLC(2), CCND2(1), CCND3(2), CISH(2), CLCF1(1), CNTF(2), CNTFR(2), CREBBP(11), CSF2RB(5), CSF3(1), CSF3R(3), EP300(10), EPOR(2), GH1(1), GH2(2), GHR(5), GRB2(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(1), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(2), IFNAR2(3), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RA(1), IL10RB(1), IL11(1), IL11RA(1), IL12B(1), IL12RB1(3), IL12RB2(3), IL13(1), IL13RA1(1), IL13RA2(4), IL15RA(1), IL2(1), IL20(1), IL20RA(1), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23R(5), IL26(1), IL28A(1), IL28B(1), IL2RA(1), IL2RG(2), IL3(1), IL6(1), IL6ST(1), IL7R(3), IRF9(4), JAK1(5), JAK2(4), JAK3(3), LEPR(7), LIF(2), LIFR(6), OSM(2), OSMR(3), PIAS1(3), PIAS2(4), PIAS3(1), PIAS4(3), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PIM1(1), PRL(1), PRLR(2), PTPN11(3), SOCS2(2), SOCS3(2), SOCS4(1), SOCS7(2), SOS1(3), SOS2(4), SPRED1(2), SPRED2(4), SPRY1(2), SPRY2(1), SPRY4(3), STAM(3), STAM2(1), STAT1(3), STAT2(1), STAT3(4), STAT4(4), STAT5B(4), TPO(12), TSLP(3), TYK2(4) 28691558 307 77 292 99 69 99 80 21 36 2 0.033 0.13 161 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(9), GNAS(12), GNB1(1), GNGT1(2), PRKACA(1), PRKAR1A(2) 1348487 27 17 26 8 7 13 2 1 4 0 0.034 0.13 162 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), DRD1(2), DRD2(5), GRM1(11), PLCB1(8), PPP1CA(2), PPP2CA(1), PPP3CA(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5) 3162740 45 30 45 18 14 15 7 4 5 0 0.034 0.13 163 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(1), AKT3(3), BRAF(5), EIF4B(2), EIF4EBP1(1), HIF1A(1), IGF1(2), MAPK1(2), MAPK3(1), PDPK1(1), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PRKAA1(1), PRKAA2(2), RHEB(1), RICTOR(4), RPS6(1), RPS6KA1(2), RPS6KA2(6), RPS6KA6(6), RPS6KB1(2), RPS6KB2(2), TSC1(1), TSC2(3), ULK1(1), ULK2(2), ULK3(1), VEGFC(3) 10939782 114 51 102 44 29 42 30 4 9 0 0.034 0.13 164 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(4), F2R(2), F3(1), F5(8), F7(5), FGA(4), FGB(3), FGG(2), PROC(2), SERPINC1(2), TFPI(2) 3283504 38 28 38 14 8 12 14 1 3 0 0.035 0.13 165 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(4), BLNK(1), ELK1(2), GRB2(1), JUN(2), LYN(2), MAP2K1(3), MAP3K1(5), MAPK1(2), MAPK3(1), MAPK8IP3(7), PAPPA(12), RPS6KA1(2), SHC1(3), SOS1(3), SYK(1), VAV1(2), VAV2(5), VAV3(6) 6536418 64 40 64 34 13 24 13 5 9 0 0.036 0.14 166 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), CD3G(2), CD8A(1), ICAM1(2), ITGAL(6), ITGB2(5), PTPRC(13) 2154866 32 21 31 15 7 9 8 3 5 0 0.037 0.14 167 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(6), ALDH3A1(4), ALDH3B2(3), AOC2(4), AOC3(2), DDC(3), EPX(3), GOT1(2), GOT2(2), HPD(1), LPO(2), MAOA(1), MAOB(2), MPO(5), PRDX6(1), TAT(1), TPO(12) 4443530 54 33 54 15 18 21 5 4 4 2 0.037 0.14 168 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(3), ST3GAL2(3), ST3GAL4(1), ST3GAL5(1), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(3) 1125845 14 14 14 5 8 2 3 1 0 0 0.041 0.15 169 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(3), CFL1(1), GNAQ(1), GNAS(12), GNB1(1), GNGT1(2), LIMK1(2), MAP2K1(3), MAPK1(2), MAPK3(1), MYL2(1), NOX1(4), PIK3C2G(3), PLCB1(8), PPP1R12B(2), PTK2(5), RAF1(6), ROCK2(2) 5173168 59 35 58 18 9 27 10 2 11 0 0.042 0.15 170 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(7), EXT2(3), EXTL1(3), EXTL2(2), EXTL3(5), GLCE(2), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(2), HS6ST1(2), HS6ST2(1), HS6ST3(3), NDST1(8), NDST2(5), NDST3(3), NDST4(7) 4275684 63 35 63 25 17 26 15 0 5 0 0.042 0.15 171 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(2), AKT2(1), AKT3(3), BAD(1), BCR(4), BLNK(1), BTK(1), CSK(2), DAG1(7), EPHB2(10), GRB2(1), ITPKA(1), ITPKB(4), LYN(2), MAP2K1(3), MAP2K2(1), MAPK1(2), NFAT5(5), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), PI3(2), PIK3CA(23), PIK3CD(6), PIK3R1(5), PLCG2(5), PPP1R13B(3), RAF1(6), SERPINA4(1), SHC1(3), SOS1(3), SOS2(4), SYK(1), VAV1(2) 10709426 130 51 115 38 29 37 34 9 19 2 0.043 0.15 172 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(1), ACTN1(2), ACTR2(2), AKT1(2), AKT2(1), AKT3(3), ANGPTL2(3), ARHGEF6(8), ARHGEF7(7), BCAR1(3), BRAF(5), CAV1(2), CDC42(1), CDKN2A(2), CRK(1), CSE1L(2), DOCK1(10), EPHB2(10), FYN(3), GRB2(1), GRB7(6), GRLF1(8), ITGA1(4), ITGA10(4), ITGA11(5), ITGA2(3), ITGA3(6), ITGA4(7), ITGA5(4), ITGA6(2), ITGA7(5), ITGA8(3), ITGA9(6), ITGB3BP(1), MAP2K4(5), MAP2K7(8), MAP3K11(3), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP3(7), MAPK9(1), MYLK(7), MYLK2(2), P4HB(1), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PIK3CA(23), PIK3CB(4), PKLR(4), PLCG1(9), PLCG2(5), PTEN(5), PTK2(5), RAF1(6), RHO(1), ROCK1(5), ROCK2(2), SHC1(3), SOS1(3), SOS2(4), TERF2IP(3), TLN1(9), TLN2(11), VASP(2), ZYX(2) 24984316 296 72 280 98 92 91 52 20 41 0 0.044 0.16 173 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(2), ABP1(6), ACADL(1), ACADM(1), ACADSB(2), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), AOC2(4), AOC3(2), CNDP1(1), DPYD(12), DPYS(1), EHHADH(1), GAD1(3), GAD2(3), HADHA(2), MLYCD(2), SDS(1), SMS(2), UPB1(2) 5860379 69 35 68 15 18 25 13 5 6 2 0.044 0.16 174 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(1), AKT3(3), ASAH1(1), BRAF(5), DAG1(7), DRD2(5), EGFR(7), EPHB2(10), GRB2(1), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), KCNJ3(3), MAPK1(2), PI3(2), PIK3CB(4), PITX2(2), PLCB1(8), PLCB2(3), PLCB3(6), PLCB4(6), RAF1(6), RGS20(2), SHC1(3), SOS1(3), SOS2(4), STAT3(4), TERF2IP(3) 11970399 143 49 140 54 35 56 24 7 19 2 0.045 0.16 175 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(6), AGXT(1), AGXT2(4), ALAS2(4), AMT(3), AOC2(4), AOC3(2), BHMT(5), CBS(3), CHDH(3), CHKA(1), CTH(2), DAO(3), DLD(2), DMGDH(1), GARS(1), GATM(1), GCAT(3), GLDC(5), MAOA(1), MAOB(2), PEMT(1), PISD(2), PLCB2(3), PLCG1(9), PLCG2(5), PSPH(2), SARDH(2), SARS(2), SHMT1(1), SHMT2(2), TARS(3) 8610819 89 43 88 34 21 29 17 10 10 2 0.045 0.16 176 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(2), CD36(1), CITED2(1), CREBBP(11), DUSP1(1), DUT(1), EHHADH(1), EP300(10), HSD17B4(2), JUN(2), LPL(1), MAPK1(2), MAPK3(1), ME1(3), NCOA1(7), NCOR1(10), NCOR2(12), NR0B2(1), NR2F1(3), NRIP1(7), PDGFA(1), PIK3CA(23), PIK3R1(5), PPARA(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PTGS2(1), RB1(6), RELA(2), RXRA(2), SP1(2), STAT5B(4), TNF(1) 12674501 140 54 127 39 36 39 37 6 22 0 0.046 0.16 177 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(1), FLT3(4), IGF1(2), IL11(1), IL3(1), IL6(1), KITLG(3), TGFB1(2), TGFB2(4), TGFB3(3) 1711444 22 18 22 7 4 8 5 2 3 0 0.046 0.16 178 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(1), EGF(4), EGFR(7), GRB2(1), MAP2K1(3), MAPK1(2), MAPK3(1), PTPRB(10), RAF1(6), RASA1(10), SHC1(3), SOS1(3), SPRY1(2), SPRY2(1), SPRY4(3) 4923926 57 33 56 16 13 19 10 2 11 2 0.047 0.16 179 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), AKT2(1), AKT3(3), BAD(1), CASP9(1), CDC42(1), KDR(7), KRAS(7), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK3(3), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), NOS3(2), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLCG1(9), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKCG(4), PTGS2(1), PTK2(5), PXN(2), RAC2(1), RAF1(6), SH2D2A(1), SHC2(2), SPHK1(4) 14866873 174 57 158 51 51 57 42 9 15 0 0.050 0.17 180 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(9), FSHB(1), FSHR(11), GNAS(12), XPO1(2) 1941002 35 21 33 12 8 15 7 2 3 0 0.050 0.17 181 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(11), C5(7), C6(7), C7(2), ICAM1(2), IL6(1), IL8(1), ITGA4(7), ITGAL(6), ITGB1(2), ITGB2(5), SELP(2), SELPLG(5), TNF(1), VCAM1(4) 5023277 63 34 63 21 14 23 13 6 7 0 0.051 0.17 182 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 CNR1(4), DNMT1(10), MTNR1A(2), MTNR1B(2), PTAFR(2), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), TBXA2R(6) 2366336 37 24 37 13 8 20 7 0 2 0 0.052 0.17 183 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(5), CALCR(2), CALCRL(4), CD97(1), CRHR1(1), CRHR2(3), ELTD1(8), EMR1(8), EMR2(2), GLP1R(1), GLP2R(3), GPR64(5), LPHN1(6), LPHN2(10), LPHN3(9), SCTR(2), VIPR1(2) 5550223 72 38 72 16 22 23 17 4 6 0 0.052 0.17 184 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(13), MAP2(13), PPP1CA(2), PPP2CA(1), PRKACB(2), PRKACG(2), PRKAG1(1), PRKAR2A(1), PRKAR2B(5), PRKCE(3) 3661357 43 28 42 17 7 10 15 7 4 0 0.055 0.18 185 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(2), ABP1(6), ACADM(1), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), AOC2(4), AOC3(2), CNDP1(1), DPYD(12), DPYS(1), EHHADH(1), GAD1(3), GAD2(3), HADHA(2), MLYCD(2), SMS(2), SRM(1), UPB1(2) 5464438 59 33 58 13 16 21 12 3 5 2 0.056 0.19 186 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALNT1(2), B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GNT1(1), B3GNT2(1), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALNT1(2), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), FUT1(1), FUT4(1), FUT7(1), FUT9(1), GCNT2(2), PIGA(2), PIGB(3), PIGC(1), PIGG(5), PIGL(1), PIGM(4), PIGN(2), PIGO(1), PIGQ(1), PIGS(1), PIGT(3), PIGV(2), PIGX(2), PIGZ(2), ST3GAL1(3), ST3GAL2(3), ST3GAL3(2), ST3GAL4(1), ST3GAL5(1), ST3GAL6(2), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC6(2), ST8SIA1(3), ST8SIA5(2) 10013038 83 49 82 29 21 32 16 8 6 0 0.058 0.19 187 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(3) 144172 3 3 3 1 1 0 1 0 1 0 0.059 0.20 188 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(4), CPS1(8), GLS(4), GLUD1(3), GOT1(2) 1502767 22 17 22 5 3 10 7 0 2 0 0.060 0.20 189 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(1), CSK(2), CTLA4(2), DAG1(7), EPHB2(10), FBXW7(8), GRAP2(1), GRB2(1), ITK(2), ITPKA(1), ITPKB(4), LCK(1), LCP2(6), MAPK1(2), NCK1(2), NFAT5(5), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PLCG1(9), PTPRC(13), RAF1(6), RASGRP1(3), RASGRP2(2), RASGRP3(1), RASGRP4(2), SOS1(3), SOS2(4), VAV1(2), ZAP70(3) 11416986 131 47 125 43 30 37 31 10 21 2 0.061 0.20 190 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(8), HSD17B1(1), HSD17B2(1), HSD17B3(2), HSD17B4(2), HSD17B7(1), HSD3B1(1), HSD3B2(1) 1634304 18 16 18 4 3 5 6 1 3 0 0.062 0.20 191 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), ADRBK2(4), ARRB2(2), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CLCA1(2), CLCA2(4), CLCA4(4), CNGA3(4), CNGA4(5), CNGB1(6), GUCA1A(1), PDE1C(2), PRKACA(1), PRKACB(2), PRKACG(2), PRKG1(4), PRKG2(6), PRKX(1) 6165614 62 37 60 23 4 22 22 6 8 0 0.062 0.20 192 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(3), BCAR1(3), CAPN1(1), CAPN11(3), CAPN2(3), CAPN3(4), CAPN5(2), CAPN6(5), CAPN7(5), CAPN9(3), CAPNS1(1), CAV1(2), CDC42(1), CRK(1), CSK(2), DOCK1(10), FYN(3), GIT2(1), GRB2(1), ITGA10(4), ITGA11(5), ITGA2(3), ITGA2B(5), ITGA3(6), ITGA4(7), ITGA5(4), ITGA6(2), ITGA7(5), ITGA8(3), ITGA9(6), ITGAD(3), ITGAE(4), ITGAL(6), ITGAM(4), ITGAV(2), ITGAX(5), ITGB1(2), ITGB2(5), ITGB3(5), ITGB4(10), ITGB5(2), ITGB7(2), ITGB8(6), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAPK10(3), MAPK4(3), MAPK6(1), MAPK7(8), MYLK2(2), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PDPK1(1), PIK3R2(3), PTK2(5), PXN(2), RAC2(1), RAP1B(2), RAPGEF1(6), RHO(1), ROCK1(5), ROCK2(2), SHC1(3), SHC3(3), SORBS1(5), SOS1(3), TLN1(9), TNS1(12), VASP(2), VAV2(5), VAV3(6), VCL(2), ZYX(2) 27556004 277 73 277 119 87 83 49 22 36 0 0.063 0.20 193 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(7), ELK1(2), GNAS(12), GNB1(1), GNGT1(2), GRB2(1), IGF1R(11), ITGB1(2), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(1), NGFR(2), PDGFRA(2), PPP2CA(1), PTPRR(4), RAF1(6), RPS6KA1(2), SHC1(3), SOS1(3), STAT3(4) 6778478 73 38 72 29 14 34 11 4 10 0 0.063 0.20 194 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), AKR1C4(1), AKR1D1(2), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), SOAT2(2), SRD5A1(2), SRD5A2(2) 4716712 66 31 65 14 10 27 13 6 10 0 0.064 0.20 195 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(9), GNAS(12), GNB1(1), GNGT1(2), PPP2CA(1), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACB(2), PRKACG(2), PRKAG1(1), PRKAG2(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5) 3052217 45 27 44 18 12 20 4 3 6 0 0.064 0.20 196 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(2), ITGA4(7), ITGAL(6), ITGAM(4), ITGB1(2), ITGB2(5), SELE(2), SELL(3), SELP(2) 3525830 36 26 36 22 9 12 3 5 7 0 0.068 0.21 197 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(2), AKT1(2), APC(18), ASAH1(1), DAG1(7), DLG4(4), EPHB2(10), GNAI1(1), GNAQ(1), ITPR1(13), ITPR2(12), ITPR3(10), KCNJ3(3), MAPK1(2), PITX2(2), PTX3(1), RHO(1), RYR1(24) 9417464 114 45 110 46 26 44 18 6 18 2 0.069 0.21 198 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), CD3G(2), CD4(3), ICAM1(2), ITGAL(6), ITGB2(5), PTPRC(13) 2267384 34 20 33 18 6 11 8 4 5 0 0.070 0.22 199 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(4), CD44(3), FCGR3A(1), IL1B(1), SELL(3), TGFB1(2), TGFB2(4), TNF(1), TNFRSF1A(3), TNFRSF8(2), TNFSF8(1) 2823723 25 21 25 13 6 6 6 2 5 0 0.070 0.22 200 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(18), ASAH1(1), CASP3(1), CERK(3), CREB1(4), CREB3(3), CREB5(2), CXCL2(1), DAG1(7), EPHB2(10), GNAQ(1), ITPKA(1), ITPKB(4), JUN(2), MAP2K4(5), MAP2K7(8), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP3(7), MAPK9(1) 5877403 89 34 85 21 22 32 12 1 18 4 0.077 0.24 201 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(11), ACTN3(1), BCAR1(3), CSK(2), CTNNA1(3), CTNNA2(9), CTNNB1(8), PTK2(5), PXN(2), VCL(2) 4250281 48 30 47 21 14 15 10 5 4 0 0.077 0.24 202 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(3), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(1), HDAC3(3), NCOA1(7), NCOA2(10), NCOA3(7), NCOR2(12), POLR2A(6), RARA(1), RXRA(2), TBP(2) 5151888 62 34 62 24 15 30 6 4 7 0 0.078 0.24 203 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(4), ADRA1B(2), ADRA1D(1), ADRA2A(2), ADRA2C(3), ADRB1(2), ADRB2(2), ADRB3(1), CHRM1(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(3), DRD1(2), DRD2(5), DRD3(7), DRD5(8), HRH1(3), HRH2(2), HTR1A(5), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(3), HTR2A(1), HTR2B(4), HTR2C(2), HTR4(3), HTR5A(2), HTR7(3) 5232486 88 38 85 29 29 26 19 6 8 0 0.078 0.24 204 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(2), FOSB(2), GRIA2(8) 793079 12 11 12 5 5 2 2 2 1 0 0.078 0.24 205 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT5(2), FUT8(2), ST3GAL1(3), ST3GAL2(3), ST3GAL3(2), ST3GAL4(1) 1620073 22 20 21 8 10 7 4 0 1 0 0.079 0.24 206 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(6), AGXT(1), AGXT2(4), AKR1B10(1), ALAS2(4), AMT(3), AOC2(4), AOC3(2), BHMT(5), CBS(3), CHDH(3), CHKA(1), CTH(2), DAO(3), DLD(2), DMGDH(1), GARS(1), GATM(1), GCAT(3), GLDC(5), GNMT(2), HSD3B7(1), MAOA(1), MAOB(2), PEMT(1), PHGDH(1), PIPOX(2), PISD(2), PSPH(2), RDH11(1), RDH12(1), SARDH(2), SARS(2), SARS2(1), SDS(1), SHMT1(1), SHMT2(2), TARS(3), TARS2(5) 8739031 88 42 88 34 21 29 17 10 9 2 0.085 0.25 207 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(1), BRAF(5), CREB1(4), CREB3(3), CREB5(2), MAPK1(2), RAF1(6), SNX13(5), TERF2IP(3) 2340667 32 25 32 9 7 14 3 3 5 0 0.086 0.25 208 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(4), DYRK1B(4), GLI2(5), GLI3(11), GSK3B(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), SMO(6), SUFU(3) 3336571 46 26 46 22 11 18 6 4 7 0 0.087 0.26 209 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(2), AKT2(1), AKT3(3), BAD(1), GRB2(1), GSK3B(1), IRS1(5), IRS2(3), JAK1(5), JAK3(3), MAP4K1(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(23), PIK3CD(6), PIK3R1(5), PPP1R13B(3), RAF1(6), SHC1(3), SOS1(3), SOS2(4) 7529529 84 43 71 27 27 21 21 6 7 2 0.087 0.26 210 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD2(2), CD33(2), CD5(4), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(1), IL13(1), IL3(1), ITGAX(5), TLR2(2), TLR4(9), TLR7(3), TLR9(7) 3737034 46 28 43 23 5 17 19 1 4 0 0.090 0.27 211 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(6), AOC2(4), AOC3(2), CES1(5), ESD(1) 1204182 18 13 18 5 4 8 3 1 0 2 0.093 0.27 212 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(2), CCKBR(3), CCR2(1), CCR3(3), CELSR1(13), CELSR2(15), CELSR3(15), CHRM2(6), CHRM3(4), CIDEB(1), EDNRA(2), EMR2(2), EMR3(3), F2R(2), FSHR(11), GNRHR(2), GPR116(8), GPR132(1), GPR133(6), GPR135(2), GPR143(1), GPR55(5), GPR61(3), GPR84(1), GRM1(11), GRPR(3), LGR6(2), LPHN2(10), LPHN3(9), LTB4R2(2), NTSR1(1), OR8G2(4), P2RY13(4), PTGFR(3), SMO(6), TAAR5(1), TSHR(5), VN1R1(3) 13575975 176 55 173 46 37 65 45 13 16 0 0.097 0.28 213 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), AGPAT1(1), AGPAT3(2), AGPAT4(4), AKR1B1(3), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), CEL(6), DGKA(1), DGKB(3), DGKE(1), DGKH(8), DGKQ(2), DGKZ(1), GK(2), GLB1(2), LCT(10), LIPC(1), LIPF(1), LIPG(3), LPL(1), PNLIP(2), PNLIPRP1(2), PNLIPRP2(2), PPAP2C(4) 9731743 105 44 104 37 20 41 19 12 13 0 0.098 0.28 214 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(2), GLB1(2), HEXA(1), HEXB(2), LCT(10), SLC33A1(4), ST3GAL1(3), ST3GAL2(3), ST3GAL5(1), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC6(2), ST8SIA1(3), ST8SIA5(2) 3317818 39 26 39 19 14 10 9 4 2 0 0.10 0.29 215 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(3), ADCY4(4), ADCY6(5), ADCY8(8), CACNA1A(9), CACNA1B(1), GNAS(12), GNAT3(2), GNB1(1), GNB3(1), GRM4(3), ITPR3(10), KCNB1(3), PDE1A(2), PLCB2(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKX(1), SCNN1A(2), SCNN1B(3), SCNN1G(4), TAS1R1(4), TAS1R2(2), TAS2R1(1), TAS2R10(2), TAS2R16(3), TAS2R3(1), TAS2R38(2), TAS2R39(3), TAS2R4(1), TAS2R40(3), TAS2R41(1), TAS2R43(1), TAS2R50(1), TAS2R60(3), TAS2R7(1), TAS2R8(1), TAS2R9(1), TRPM5(1) 11551715 114 48 112 46 25 51 22 7 9 0 0.10 0.29 216 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(2), ITGA4(7), ITGAL(6), ITGB1(2), ITGB2(5), SELE(2), SELL(3) 2731554 30 22 30 15 7 9 3 5 6 0 0.10 0.29 217 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(1), AK3(3), CAD(4), CANT1(4), CDA(2), CTPS(2), CTPS2(1), DCTD(1), DHODH(1), DPYD(12), DPYS(1), DUT(1), ENTPD1(1), ENTPD3(2), ENTPD4(4), ENTPD6(1), NME6(1), NME7(1), NT5C1A(1), NT5C1B(3), NT5C2(4), NUDT2(1), PNPT1(3), POLA1(3), POLA2(1), POLD1(4), POLD3(2), POLE2(1), POLE3(1), POLR1A(7), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(9), POLR3B(5), POLR3G(1), PRIM1(1), PRIM2(3), RRM1(4), RRM2(1), RRM2B(1), TK1(2), TK2(1), TXNRD1(3), TXNRD2(3), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UPB1(2), UPP1(1), UPP2(3), UPRT(1) 16517004 137 52 137 42 25 52 28 11 21 0 0.10 0.30 218 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(4), EPHB2(10), F2(4), F2RL1(3), JUN(2), MAP2K5(1), MAPK1(2), MAPK7(8), MAPK8(4), MYEF2(3), PLD1(6), PLD2(10), PLD3(5), PTK2(5), RAF1(6), RASAL1(1), TEC(3), VAV1(2) 5612068 80 34 77 18 28 26 12 4 10 0 0.11 0.30 219 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(3), ANXA2(1), ANXA4(2), ANXA5(1), ANXA6(2), CYP11A1(2), EDN1(2), EDNRA(2), EDNRB(10), HSD11B1(1), HSD11B2(2), PLA2G4A(3), PRL(1), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), PTGIS(5), PTGS1(4), PTGS2(1), TBXAS1(2) 4223548 55 32 54 20 15 12 14 6 8 0 0.11 0.30 220 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(3), F11(2), F12(2), F13B(8), F2(4), F5(8), F7(5), F8(9), F9(3), FGA(4), FGB(3), FGG(2), LPA(6), PLAT(2), PLAU(1), PLG(9), SERPINB2(2), SERPINE1(1), SERPINF2(3), VWF(8) 7083713 85 41 85 24 17 30 19 7 12 0 0.11 0.31 221 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(5), GRB2(1), INSR(7), IRS1(5), JAK2(4), MAP2K1(3), MAPK1(2), MAPK3(1), PIK3CA(23), PIK3R1(5), PLCG1(9), RAF1(6), RPS6KA1(2), SHC1(3), SLC2A4(1), SOS1(3), SRF(1), STAT5B(4) 6676068 86 40 73 18 24 23 24 5 10 0 0.12 0.32 222 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(3), CDK5(2), F2(4), FYN(3), GNA11(1), GNAI1(1), GNB1(1), GNGT1(2), GRB2(1), JAK2(4), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), MAPT(4), MYLK(7), PLCG1(9), PTK2B(8), RAF1(6), SHC1(3), SOS1(3), STAT1(3), STAT3(4) 8455209 90 43 89 28 31 30 15 5 9 0 0.12 0.32 223 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(6), CARM1(1), CREBBP(11), EP300(10), ERCC3(3), ESR1(4), GRIP1(5), GTF2A1(2), GTF2E1(5), GTF2F1(1), HDAC1(2), HDAC2(3), HDAC3(3), HDAC4(6), HDAC5(3), HDAC6(3), MEF2C(1), NCOR2(12), NR0B1(2), NRIP1(7), PELP1(5), POLR2A(6), TBP(2) 9580921 103 44 101 31 25 39 13 4 22 0 0.12 0.32 224 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(2), BIRC2(1), BIRC3(3), CASP10(2), CASP3(1), CASP7(2), CASP8(3), CASP9(1), DFFA(2), DFFB(2), PRF1(1), SCAP(7), SREBF1(3), SREBF2(5) 3756452 35 28 35 11 7 11 7 5 5 0 0.12 0.32 225 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(4), CASP1(2), CASP3(1), CASP7(2), CASP8(3), GAPDH(1), INSR(7), ITCH(2), MAGI1(11), MAGI2(7), RERE(14), WWP1(6), WWP2(9) 4766188 69 31 68 16 15 11 13 9 21 0 0.12 0.34 226 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(3), CD4(3), HLA-DRA(2), HLA-DRB1(1), IL1B(1), IL6(1) 1075172 11 10 11 5 2 4 1 2 2 0 0.12 0.34 227 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(3), BAD(1), CABIN1(7), CALM1(1), CALM2(2), CALM3(1), CAMK2B(2), CAMK4(2), CD3E(1), CD3G(2), CDKN1A(1), CNR1(4), CREBBP(11), CSNK2A1(4), CTLA4(2), EGR2(3), EGR3(1), EP300(10), FCGR3A(1), GATA3(2), GATA4(2), GRLF1(8), GSK3B(1), ICOS(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL13(1), IL1B(1), IL2(1), IL2RA(1), IL3(1), IL6(1), IL8(1), ITK(2), KPNA5(4), MAP2K7(8), MAPK14(1), MAPK8(4), MAPK9(1), MEF2B(2), MEF2D(3), MYF5(2), NCK2(2), NFAT5(5), NFATC2(5), NFATC3(3), NFATC4(9), NFKB2(2), NFKBIB(3), NPPB(1), NUP214(8), OPRD1(1), PAK1(2), PIN1(1), PPP3CB(1), PTPRC(13), RELA(2), RPL13A(1), SP1(2), SP3(2), TGFB1(2), TNF(1), TRAF2(2), TRPV6(4), VAV1(2), VAV2(5), VAV3(6), XPO5(1) 18545919 199 57 198 81 55 58 43 16 27 0 0.12 0.34 228 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3) 2684871 37 23 36 4 6 11 8 6 6 0 0.13 0.34 229 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(1), CD3G(2), IFNG(2), IL2(1), IL2RA(1), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TGFBR2(4), TGFBR3(1), TOB1(1), TOB2(4) 2148881 27 18 26 6 5 5 11 3 3 0 0.13 0.34 230 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSR(4), GSS(1), IL8(1), NFKB1(4), NOX1(4), RELA(2), TNF(1), XDH(8) 2021600 26 17 26 8 5 10 5 3 3 0 0.13 0.35 231 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), AARS2(4), ABAT(2), ACY3(1), ADSL(4), ADSSL1(7), AGXT(1), AGXT2(4), ASL(4), ASNS(4), ASRGL1(1), ASS1(5), CAD(4), CRAT(1), DARS(1), DDO(2), DLAT(6), DLD(2), GAD1(3), GAD2(3), GOT1(2), GOT2(2), GPT(1), GPT2(3), NARS(1), NARS2(1), PC(3), PDHA1(1), PDHA2(4), PDHB(2) 7674100 81 41 80 31 20 37 14 6 4 0 0.13 0.35 232 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(3), EEF1D(4), EEF1G(2), EEF2K(6), EIF1AX(1), EIF1AY(1), EIF2AK1(3), EIF2AK2(2), EIF2AK3(6), EIF2B1(3), EIF2B3(3), EIF2B4(5), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF4A1(2), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4EBP2(1), EIF4G1(7), EIF4G3(5), EIF5(2), EIF5A(2), EIF5B(6), ETF1(2), GSPT2(1), KIAA0664(6), PABPC1(2), PABPC3(5), PAIP1(1), SLC35A4(3) 9010484 96 44 94 29 23 38 18 10 7 0 0.13 0.35 233 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), PARK2(5), SNCAIP(5), UBE2F(2), UBE2G2(1), UBE2L6(1) 1286509 15 14 15 4 3 5 3 2 2 0 0.13 0.35 234 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AGPAT1(1), AGPAT3(2), AGPAT4(4), AGPAT6(1), AKR1B1(3), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), CEL(6), DAK(2), DGKA(1), DGKB(3), DGKE(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), GK(2), GK2(1), GLB1(2), GPAM(4), LCT(10), LIPA(1), LIPC(1), LIPF(1), LIPG(3), LPL(1), PNLIP(2), PNLIPRP1(2), PNLIPRP2(2), PNPLA3(1), PPAP2C(4) 11868654 114 47 113 37 20 45 23 12 14 0 0.14 0.37 235 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(3), HLA-DRA(2), HLA-DRB1(1) 485982 6 6 6 5 2 2 0 2 0 0 0.14 0.37 236 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(1), BMPR1B(2), BMPR2(9) 1257914 17 13 16 4 3 6 3 0 3 2 0.14 0.38 237 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(4), ACE2(5), AGT(1), AGTR1(1), AGTR2(1), ANPEP(3), CPA3(1), CTSG(2), ENPEP(6), LNPEP(9), MAS1(1), MME(2), NLN(5), REN(3), THOP1(5) 4290314 49 29 49 15 15 16 11 6 1 0 0.15 0.39 238 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(1), ACAD9(2), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AKR1B10(1), AKR1C4(1), AKR1D1(2), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), HSD3B7(1), LIPA(1), RDH11(1), RDH12(1), SLC27A5(3), SOAT1(4), SOAT2(2), SRD5A1(2), SRD5A2(2) 6477233 75 34 74 17 14 29 13 9 10 0 0.15 0.39 239 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(3), CD80(1), HLA-DRA(2), HLA-DRB1(1), IL10(1), IL2(1) 805182 9 9 9 5 2 3 2 2 0 0 0.16 0.40 240 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(4), ABCA10(7), ABCA12(17), ABCA13(19), ABCA2(6), ABCA3(10), ABCA4(6), ABCA5(6), ABCA6(4), ABCA7(3), ABCA8(5), ABCA9(8), ABCB1(8), ABCB10(5), ABCB11(4), ABCB4(10), ABCB5(2), ABCB6(2), ABCB8(4), ABCB9(2), ABCC1(4), ABCC10(3), ABCC11(9), ABCC12(7), ABCC2(11), ABCC3(4), ABCC4(4), ABCC5(8), ABCC6(6), ABCC8(6), ABCC9(20), ABCD1(2), ABCD2(4), ABCD3(1), ABCD4(3), ABCG1(2), ABCG2(3), ABCG4(3), ABCG8(4), CFTR(2), TAP1(2), TAP2(5) 24248826 245 68 240 88 67 70 64 10 34 0 0.16 0.40 241 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), XYLT1(5), XYLT2(3) 1412726 21 15 21 6 5 6 7 0 3 0 0.16 0.40 242 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), XYLT1(5), XYLT2(3) 1412726 21 15 21 6 5 6 7 0 3 0 0.16 0.40 243 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(3), G6PD(1), GCLM(2), GGT1(7), GPX1(1), GPX3(1), GPX4(3), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(1), GSTP1(1), GSTT1(1), GSTT2(1), GSTZ1(1), IDH1(1), IDH2(1), MGST1(1), MGST2(1), MGST3(1), PGD(1) 3697001 37 26 36 9 7 12 13 4 1 0 0.16 0.40 244 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(2), LDLR(3), NR0B2(1), NR1H4(2), RXRA(2) 1094191 10 10 10 7 2 4 0 3 1 0 0.16 0.40 245 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(4), ENO1(2), GPI(4), HK1(5), PFKL(6), PGK1(1), PKLR(4), TPI1(1) 1779673 27 20 27 10 10 14 3 0 0 0 0.16 0.40 246 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX15(2), ALOX15B(1), ALOX5(2), GGT1(7), LTA4H(4), PLA2G6(3), PTGIS(5), PTGS1(4), PTGS2(1), TBXAS1(2) 3096772 33 25 32 9 9 12 6 5 1 0 0.16 0.40 247 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 5 CD3E(1), CD3G(2), CD4(3) 504735 6 6 5 5 0 2 1 1 2 0 0.16 0.40 248 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(3), IL1R1(2), IRAK1(4), MAP3K1(5), MAP3K14(1), MAP3K7(7), MYD88(2), NFKB1(4), RELA(2), TLR4(9), TNF(1), TNFAIP3(4), TNFRSF1A(3), TRAF6(3) 5009046 50 32 48 13 6 22 15 1 6 0 0.17 0.41 249 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(2), COASY(1), DPYD(12), DPYS(1), ENPP1(1), ENPP3(3), PANK1(1), PANK2(2), PANK4(2), UPB1(2) 2845668 27 20 27 4 4 7 10 2 4 0 0.17 0.41 250 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(5), JAK2(4), JAK3(3), PIAS1(3), PIAS3(1), PTPRU(10), REG1A(4), SOAT1(4) 2861362 36 23 36 11 7 17 4 2 4 2 0.17 0.42 251 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(5), COL4A2(4), COL4A3(3), COL4A4(4), COL4A5(2), COL4A6(5), F10(3), F11(2), F12(2), F2(4), F2R(2), F5(8), F8(9), F9(3), FGA(4), FGB(3), FGG(2), KLKB1(4), PROC(2), SERPINC1(2), SERPING1(5) 9021124 78 43 78 29 19 23 18 8 10 0 0.17 0.43 252 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 AK3(3), CAD(4), CANT1(4), CDA(2), CTPS(2), CTPS2(1), DCTD(1), DHODH(1), DPYD(12), DPYS(1), DUT(1), ENTPD1(1), NUDT2(1), POLD1(4), POLG(1), POLL(1), POLQ(11), POLR1B(2), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(8), RRM1(4), RRM2(1), TK1(2), TK2(1), TXNRD1(3), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UNG(1), UPB1(2), UPP1(1) 11716502 93 43 93 33 15 37 22 6 13 0 0.17 0.43 253 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12(2), ALOX12B(2), ALOX15(2), ALOX15B(1), ALOX5(2), CBR1(1), CBR3(1), CYP2B6(1), CYP2C18(4), CYP2C19(4), CYP2C9(1), CYP2E1(3), CYP2J2(2), CYP2U1(2), CYP4A22(1), CYP4F2(1), CYP4F3(3), DHRS4(1), EPHX2(4), GGT1(7), GPX1(1), GPX3(1), GPX4(3), GPX6(1), GPX7(2), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PTGES2(4), PTGIS(5), PTGS1(4), PTGS2(1), TBXAS1(2) 7949277 90 41 88 19 24 34 17 9 6 0 0.18 0.43 254 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3) 1609300 21 17 21 4 6 9 4 0 2 0 0.18 0.43 255 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3) 1609300 21 17 21 4 6 9 4 0 2 0 0.18 0.43 256 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 109 A4GNT(3), ALG1(2), ALG10(3), ALG10B(1), ALG13(1), ALG3(2), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), B4GALT5(2), B4GALT7(1), C1GALT1(1), C1GALT1C1(3), CHPF(2), CHST1(8), CHST11(1), CHST12(5), CHST13(1), CHST2(6), CHST3(1), CHST6(4), CHST7(1), EXT1(7), EXT2(3), EXTL1(3), EXTL2(2), EXTL3(5), FUT11(1), FUT8(2), GALNT1(2), GALNT10(3), GALNT11(3), GALNT12(1), GALNT13(3), GALNT14(5), GALNT2(2), GALNT3(1), GALNT4(1), GALNT5(3), GALNT6(1), GALNT8(3), GALNTL1(2), GALNTL2(4), GALNTL4(4), GALNTL5(4), GANAB(2), GCNT1(1), GCNT3(2), GCNT4(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(2), HS6ST1(2), HS6ST2(1), HS6ST3(3), MAN1A2(1), MAN1B1(1), MAN1C1(3), MAN2A1(6), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), MGAT5B(2), NDST1(8), NDST2(5), NDST3(3), NDST4(7), OGT(2), RPN1(1), RPN2(2), ST3GAL1(3), ST3GAL2(3), ST3GAL3(2), ST3GAL4(1), ST6GALNAC1(1), STT3B(4), UST(3), WBSCR17(7), XYLT1(5), XYLT2(3) 22628753 240 66 238 97 60 92 58 9 21 0 0.18 0.43 257 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(4), GLUD1(3), GLUD2(3) 857318 14 10 14 4 2 7 3 1 1 0 0.18 0.44 258 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), AKT2(1), AKT3(3), CISH(2), GRB2(1), IARS(6), IL13RA1(1), IL2RG(2), INPP5D(1), JAK1(5), JAK2(4), JAK3(3), NR0B2(1), PI3(2), PIK3CA(23), PPP1R13B(3), RPS6KB1(2), SERPINA4(1), SHC1(3), SOS1(3), SOS2(4), TYK2(4) 7518224 77 39 64 27 21 21 18 6 9 2 0.18 0.44 259 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(4), FADS2(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3) 2063628 26 20 26 5 8 12 5 0 1 0 0.20 0.48 260 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDC34(1), CDK2(2), CUL1(5), FBXW7(8), RB1(6) 1717030 22 17 19 2 3 7 6 2 4 0 0.20 0.48 261 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 12 ADCY1(9), ADRB2(2), GNAS(12), PLCE1(7), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5) 2960447 42 25 41 18 12 19 4 4 3 0 0.20 0.48 262 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(3), ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADCY9(4), ADK(1), ADSL(4), ADSSL1(7), AK5(2), AK7(2), ALLC(2), AMPD1(2), AMPD2(5), AMPD3(5), ATIC(3), CANT1(4), DGUOK(1), ENPP1(1), ENPP3(3), ENTPD1(1), ENTPD3(2), ENTPD4(4), ENTPD6(1), FHIT(1), GART(4), GDA(1), GMPR(2), GMPS(3), GUCY1A2(3), GUCY1A3(7), GUCY1B3(4), GUCY2C(1), GUCY2D(5), GUCY2F(5), GUK1(2), IMPDH1(1), NME6(1), NME7(1), NPR1(6), NPR2(2), NT5C1A(1), NT5C1B(3), NT5C2(4), NUDT2(1), NUDT5(1), NUDT9(1), PAPSS1(4), PAPSS2(2), PDE10A(1), PDE11A(2), PDE1A(2), PDE1C(2), PDE2A(6), PDE3B(9), PDE4A(4), PDE4B(4), PDE4C(2), PDE5A(5), PDE7A(5), PDE7B(2), PDE8A(5), PDE8B(2), PDE9A(5), PFAS(2), PKLR(4), PKM2(2), PNPT1(3), POLA1(3), POLA2(1), POLD1(4), POLD3(2), POLE2(1), POLE3(1), POLR1A(7), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(9), POLR3B(5), POLR3G(1), PPAT(1), PRIM1(1), PRIM2(3), PRPS1(1), PRPS1L1(1), PRPS2(3), PRUNE(2), RRM1(4), RRM2(1), RRM2B(1), XDH(8) 33403615 315 76 314 119 81 107 76 29 22 0 0.21 0.51 263 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(4), ESR2(5), ITPKA(1), PDE1A(2), PDE1B(1), PLCB1(8), PLCB2(3), PRL(1), TRH(1) 2273236 26 18 25 9 4 12 5 0 5 0 0.22 0.51 264 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(10), GNA12(1), PRKACB(2), PRKACG(2), PRKAG1(1), PRKAR2A(1), PRKAR2B(5) 2038757 22 16 22 7 3 10 4 3 2 0 0.22 0.51 265 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(2), EGR1(3), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), NGFR(2), RAF1(6) 1696149 20 16 20 12 4 10 3 2 1 0 0.22 0.51 266 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(1), CHKA(1), PCYT1A(6), PDHA1(1), PDHA2(4), PEMT(1) 1439592 17 15 17 5 6 7 3 1 0 0 0.22 0.51 267 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(6), ADC(1), AGMAT(2), ALDH18A1(3), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), AMD1(2), AOC2(4), AOC3(2), ARG1(1), ASL(4), ASS1(5), CPS1(8), GATM(1), MAOA(1), MAOB(2), NAGS(1), ODC1(3), OTC(1), SMS(2), SRM(1) 6001359 64 36 64 14 14 24 17 4 3 2 0.22 0.51 268 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACADL(1), ACADM(1), ACOX1(2), ACOX2(4), ACOX3(4), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(2), ACSL6(4), ADIPOQ(2), ANGPTL4(1), APOA5(4), AQP7(2), CD36(1), CPT1A(2), CPT1C(2), CPT2(3), CYP27A1(1), CYP4A22(1), CYP7A1(3), CYP8B1(4), DBI(1), EHHADH(1), FABP2(1), FABP3(1), FABP5(1), FABP6(2), FABP7(1), FADS2(4), GK(2), GK2(1), HMGCS2(1), LPL(1), ME1(3), MMP1(1), OLR1(2), PCK1(3), PCK2(4), PDPK1(1), PLTP(2), PPARA(2), PPARD(4), PPARG(1), RXRA(2), RXRG(2), SCD(4), SCP2(2), SLC27A1(1), SLC27A4(3), SLC27A5(3), SLC27A6(4), SORBS1(5), UBC(3) 13074432 119 49 119 29 31 47 18 10 13 0 0.22 0.51 269 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1), CD3G(2) 226898 3 3 2 1 0 0 1 0 2 0 0.22 0.51 270 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(1), ACAD9(2), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), DHRS7(1), ESCO2(1), MYST3(6), MYST4(12), NAT6(1), PNPLA3(1), SH3GLB1(1) 4903178 49 29 48 8 6 11 14 10 8 0 0.22 0.51 271 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(9), AMT(3), ATIC(3), GART(4), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(4), MTR(4), SHMT1(1), SHMT2(2), TYMS(1) 3599911 36 25 36 12 9 10 8 4 5 0 0.23 0.52 272 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(6), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH3B2(3), ALDH9A1(3), AOC2(4), AOC3(2), CNDP1(1), DDC(3), HARS(4), HDC(3), HNMT(1), MAOA(1), MAOB(2), PRPS1(1), PRPS2(3) 4913153 55 31 54 13 12 20 12 6 3 2 0.23 0.53 273 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(1), NR3C1(3), PPARG(1), RXRA(2), TNF(1) 1163617 9 9 9 2 2 2 3 1 1 0 0.24 0.55 274 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(2), ITGAL(6), ITGAM(4), ITGB2(5), SELE(2), SELL(3) 2416211 25 19 25 16 8 8 2 2 5 0 0.25 0.55 275 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(3), CTH(2), GGT1(7), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), PAPSS1(4), PAPSS2(2), SCLY(1), SEPHS1(1) 2517690 26 19 25 9 5 8 6 4 3 0 0.25 0.55 276 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(3), ADAM17(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), CASP3(1), CCL5(1), CDC42(1), CSK(2), EGFR(7), GIT1(2), IGSF5(1), IKBKB(3), IL8(1), JAM3(2), JUN(2), LYN(2), MAP2K4(5), MAP3K14(1), MAPK10(3), MAPK13(1), MAPK14(1), MAPK8(4), MAPK9(1), MET(3), NFKB1(4), NFKB2(2), NOD1(6), PAK1(2), PLCG1(9), PLCG2(5), PTPN11(3), PTPRZ1(13), RELA(2), TCIRG1(2), TJP1(4) 14264516 130 51 129 52 31 45 28 9 17 0 0.25 0.56 277 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(8), ACSS1(6), ACSS2(2), FH(1), IDH1(1), IDH2(1), MDH1(1), SUCLA2(3) 2654281 25 19 24 9 4 11 5 1 4 0 0.26 0.58 278 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(4), CREBBP(11), EP300(10), NCOA3(7), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RARA(1), RXRA(2) 4085494 48 27 48 17 13 15 4 6 10 0 0.26 0.58 279 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), AKT2(1), AKT3(3), BAD(1), BCR(4), BLNK(1), BTK(1), CD81(2), CR2(3), CSK(2), DAG1(7), FLOT1(1), FLOT2(3), GRB2(1), GSK3B(1), INPP5D(1), ITPR1(13), ITPR2(12), ITPR3(10), LYN(2), MAP4K1(2), MAPK1(2), MAPK3(1), NFATC2(5), NR0B2(1), PDK1(1), PIK3CA(23), PIK3CD(6), PIK3R1(5), PLCG2(5), PPP1R13B(3), PPP3CA(2), PPP3CB(1), PTPRC(13), RAF1(6), SHC1(3), SOS1(3), SOS2(4), SYK(1), VAV1(2) 15072491 160 55 147 63 40 48 42 11 19 0 0.26 0.58 280 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(2), ALDH4A1(2), ALDH5A1(3), CAD(4), CPS1(8), EPRS(3), GAD1(3), GAD2(3), GCLM(2), GFPT1(3), GLS(4), GLS2(4), GLUD1(3), GLUL(2), GMPS(3), GOT1(2), GOT2(2), GPT(1), GPT2(3), GSS(1), NADSYN1(3), PPAT(1), QARS(4) 6643217 66 36 65 28 21 22 14 5 4 0 0.27 0.59 281 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(3), G6PD(1), GCLM(2), GGT1(7), GPX1(1), GPX3(1), GPX4(3), GPX6(1), GPX7(2), GSR(4), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(1), GSTP1(1), GSTT1(1), GSTT2(1), GSTZ1(1), IDH1(1), IDH2(1), MGST1(1), MGST2(1), MGST3(1), OPLAH(4), TXNDC12(1) 4547935 49 28 48 11 11 18 12 5 3 0 0.28 0.61 282 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(2), JAK1(5), PTPRU(10), REG1A(4), STAT1(3), STAT2(1), TYK2(4) 2528064 31 20 31 10 3 16 6 1 3 2 0.28 0.61 283 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(2), BAD(1), CBL(1), GRB2(1), IL2RA(1), IL2RG(2), IRS1(5), JAK1(5), JAK3(3), MAPK1(2), MAPK3(1), NMI(1), PIK3CA(23), PIK3R1(5), RAF1(6), RPS6KB1(2), SHC1(3), SOCS3(2), SOS1(3), STAT5B(4), SYK(1) 7378308 74 38 61 26 21 16 20 4 11 2 0.28 0.61 284 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), ELK1(2), IKBKB(3), IRAK1(4), JUN(2), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K1(5), MAP3K14(1), MAP3K7(7), MAPK14(1), MAPK8(4), MYD88(2), NFKB1(4), PPARA(2), RELA(2), TIRAP(1), TLR10(1), TLR2(2), TLR3(1), TLR4(9), TLR7(3), TLR9(7), TOLLIP(1), TRAF6(3) 7403977 77 38 74 26 11 33 19 3 11 0 0.28 0.61 285 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(9), CALM1(1), CALM2(2), CALM3(1), CREB1(4), ELK1(2), GNAI1(1), GNAQ(1), GNAS(12), GNB1(1), GNGT1(2), JUN(2), MAP2K1(3), MAPK3(1), NFATC2(5), NFATC3(3), NFATC4(9), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RAF1(6) 7049399 89 39 87 24 28 34 14 4 9 0 0.29 0.63 286 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(2), ABP1(6), AOC2(4), AOC3(2), CES1(5), CES7(5), DDHD1(5), ESCO2(1), LIPA(1), MYST3(6), MYST4(12), NAT6(1), PNPLA3(1), PRDX6(1), SH3GLB1(1) 5117574 53 31 52 16 14 18 12 4 3 2 0.29 0.63 287 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG1(1), ASL(4), ASS1(5), CKMT1A(1), CKMT2(2), CPS1(8), DAO(3), EPRS(3), GATM(1), GLUD1(3), GLUD2(3), GOT1(2), GOT2(2), LAP3(1), NOS1(15), NOS3(2), OTC(1), P4HA2(6), P4HA3(1), PYCRL(1), RARS(2), RARS2(1) 7258342 70 36 69 23 21 23 17 2 7 0 0.29 0.63 288 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(6), AGMAT(2), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH4A1(2), ALDH9A1(3), AMD1(2), AOC2(4), AOC3(2), ARG1(1), ASL(4), CKMT1A(1), CKMT2(2), CPS1(8), DAO(3), GATM(1), GLUD1(3), GOT1(2), GOT2(2), MAOA(1), MAOB(2), NOS1(15), NOS3(2), ODC1(3), OTC(1), P4HA2(6), P4HA3(1), P4HB(1), RARS(2), SMS(2) 8899296 102 42 101 24 31 32 22 6 9 2 0.29 0.63 289 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(5), CBS(3), CTH(2), DNMT1(10), DNMT3A(5), DNMT3B(4), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), MTR(4) 3536470 39 23 39 26 5 21 7 3 3 0 0.29 0.63 290 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(9), CCNB1(1), CDC25C(2), GNAI1(1), GNAS(12), GNB1(1), GNGT1(2), MAPK1(2), MAPK3(1), PIN1(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RPS6KA1(2) 4121138 47 27 46 21 10 23 5 4 5 0 0.30 0.63 291 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(8), ABCB11(4), ABCB4(10), ABCC1(4), ABCC3(4), GSTP1(1) 2906715 31 21 31 12 11 4 9 1 6 0 0.30 0.64 292 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(4), F2R(2), GNAI1(1), GNB1(1), GNGT1(2), ITGA1(4), ITGB1(2), MAP2K1(3), MAPK1(2), MAPK3(1), PLA2G4A(3), PLCB1(8), PTGS1(4), PTK2(5), RAF1(6), SYK(1), TBXAS1(2) 4933901 51 30 51 20 9 17 14 3 8 0 0.30 0.64 293 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(9), AMT(3), ATIC(3), GART(4), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(4), MTR(4), SHMT1(1), SHMT2(2), TYMS(1) 3824947 36 25 36 12 9 10 8 4 5 0 0.31 0.65 294 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(2), ACTN2(11), ACTN3(1), BCAR1(3), BCR(4), CAPN1(1), CAPNS1(1), CAV1(2), CSK(2), FYN(3), GRB2(1), ITGA1(4), ITGB1(2), JUN(2), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(4), PPP1R12B(2), PTK2(5), PXN(2), RAF1(6), RAP1A(1), ROCK1(5), SHC1(3), SOS1(3), TLN1(9), VCL(2), ZYX(2) 9668967 91 44 91 40 29 29 17 8 8 0 0.31 0.65 295 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(3) 432915 5 5 5 0 1 1 1 0 2 0 0.31 0.65 296 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(7), EGF(4), EGFR(7), GRB2(1), MET(3), PDGFRA(2), SH3GLB1(1), SH3GLB2(2), SH3KBP1(4) 3896501 32 21 32 25 4 15 2 3 8 0 0.31 0.65 297 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(2), CALR(4), CANX(1), CD4(3), CD74(1), CD8A(1), CIITA(6), CREB1(4), CTSL1(2), HLA-A(8), HLA-B(10), HLA-C(4), HLA-DMA(1), HLA-DMB(2), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DRA(2), HLA-DRB1(1), HLA-E(3), HLA-F(4), HSP90AA1(1), HSP90AB1(2), IFI30(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(1), IFNA6(1), IFNA7(2), IFNA8(1), KIR2DL1(3), KIR2DL3(1), KIR2DL4(3), KIR2DS4(2), KIR3DL1(1), KLRC1(1), KLRC2(1), KLRD1(1), LGMN(2), LTA(1), PDIA3(1), PSME2(2), RFX5(3), RFXANK(1), TAP1(2), TAP2(5), TAPBP(3) 9487688 112 41 109 35 20 27 30 10 21 4 0.32 0.65 298 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 31 GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2E2(2), GTF2F1(1), GTF2F2(2), GTF2H1(1), GTF2H3(1), GTF2IRD1(7), TAF1(4), TAF10(1), TAF1L(10), TAF2(3), TAF4(2), TAF4B(2), TAF5(2), TAF5L(4), TAF6(6), TAF7(4), TAF7L(3), TBPL2(2) 7255549 65 32 64 17 23 20 7 6 9 0 0.32 0.65 299 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(2), BMP4(5), BMP5(5), BMP6(4), BMP7(2), BMP8A(1), BMP8B(1), BTRC(2), CSNK1A1L(1), CSNK1E(5), CSNK1G1(2), CSNK1G2(2), CSNK1G3(4), DHH(2), FBXW11(4), GLI1(9), GLI2(5), GLI3(11), GSK3B(1), HHIP(3), IHH(1), LRP2(32), PRKACA(1), PRKACB(2), PRKACG(2), PRKX(1), PTCH1(9), PTCH2(4), SMO(6), STK36(6), SUFU(3), WNT1(3), WNT10A(3), WNT10B(1), WNT16(2), WNT2(2), WNT2B(5), WNT3(3), WNT3A(1), WNT5A(2), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1), WNT9A(2) 12560254 168 52 165 56 50 62 23 9 24 0 0.32 0.65 300 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(9), ADRB2(2), CFTR(2), GNAS(12), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5) 2591904 37 22 36 12 11 16 4 4 2 0 0.32 0.65 301 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(2), BAG4(1), BID(1), BIRC2(1), BIRC3(3), CASP2(2), CASP3(1), CASP7(2), CASP8(3), CASP9(1), CYCS(1), DAXX(3), DFFA(2), DFFB(2), GSN(4), LMNA(2), LMNB1(1), LMNB2(3), MAP2K7(8), MAP3K1(5), MAP3K14(1), MAPK8(4), MDM2(2), NFKB1(4), NUMA1(10), PAK2(3), PRKCD(2), PRKDC(18), PSEN1(1), PSEN2(1), PTK2(5), RASA1(10), RB1(6), RELA(2), SPTAN1(8), TNF(1), TNFRSF1A(3), TRAF2(2) 14308273 131 48 129 42 23 49 27 8 22 2 0.32 0.65 302 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PLCG1(9), PTK2B(8) 1359526 17 14 16 6 7 7 2 0 1 0 0.32 0.66 303 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6(1), JAK1(5), JAK2(4), JAK3(3), PIAS3(1), PTPRU(10), REG1A(4), STAT3(4) 3159814 34 22 34 12 7 17 5 2 1 2 0.33 0.66 304 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(2), IFNGR1(2), JAK1(5), JAK2(4), PTPRU(10), REG1A(4), STAT1(3) 2319121 32 18 32 9 4 17 5 2 2 2 0.33 0.66 305 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(11), C5(7), C6(7), C7(2), C8A(3), C9(3) 2570624 33 21 33 9 9 12 7 2 3 0 0.33 0.67 306 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(7), GNAQ(1), ITPKA(1), ITPKB(4) 1260707 14 12 14 5 2 4 4 1 1 2 0.33 0.67 307 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), GPR109B(2), GPR161(2), GPR39(5), GPR45(3), GPR68(4), GPR75(3) 1974252 21 16 21 8 7 4 7 2 1 0 0.34 0.69 308 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM1(1), CALM2(2), CALM3(1), GNAQ(1), GRB2(1), JUN(2), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP3K1(5), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), PAK1(2), PLCG1(9), PTK2B(8), RAF1(6), SHC1(3), SOS1(3) 5824070 65 34 64 21 18 24 12 4 7 0 0.35 0.69 309 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BNIP1(2), GOSR1(1), GOSR2(2), SNAP25(1), SNAP29(3), STX10(1), STX11(1), STX16(3), STX18(1), STX4(1), STX5(1), STX6(3), STX7(1), STX8(1), TSNARE1(5), USE1(2), VAMP4(1), VAMP5(1), VTI1B(1) 3308375 32 23 32 10 11 14 2 3 2 0 0.35 0.69 310 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(4), CYP2C9(1) 401394 5 5 5 2 2 1 1 1 0 0 0.35 0.69 311 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(16), ASH2L(3), C17orf79(2), CARM1(1), CTCFL(1), DOT1L(8), EED(2), EHMT2(2), EZH1(1), EZH2(2), FBXO11(5), HCFC1(11), HSF4(2), JMJD4(1), JMJD6(1), KDM6A(5), MEN1(2), MLL(9), MLL2(27), MLL3(23), MLL4(20), MLL5(9), NSD1(9), OGT(2), PAXIP1(2), PPP1CA(2), PPP1CB(1), PPP1CC(2), PRDM2(15), PRDM9(5), PRMT1(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), RBBP5(1), SATB1(7), SETD1A(7), SETD2(4), SETDB1(11), SETDB2(4), SMYD3(2), SUV39H1(4), SUV39H2(1), SUV420H1(3), SUV420H2(1), SUZ12(3), WHSC1(5), WHSC1L1(6) 24537835 259 63 253 81 49 88 38 23 50 11 0.35 0.69 312 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(2), FUT1(1), FUT9(1), HEXA(1), HEXB(2), NAGA(3), ST3GAL1(3), ST3GAL2(3), ST8SIA1(3) 2176944 19 17 19 7 8 4 4 2 1 0 0.35 0.69 313 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(1), CREBBP(11), DFFA(2), DFFB(2), GZMA(1), HMGB2(2), PRF1(1), SET(1) 2137044 21 18 21 9 4 6 5 2 4 0 0.35 0.69 314 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(4), JUN(2), MAPK3(1), OPRK1(3), POLR2A(6), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5) 2528862 28 20 28 9 7 13 2 3 3 0 0.36 0.70 315 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(2), CASP3(1), CASP7(2), CASP8(3), DAXX(3), DFFA(2), DFFB(2), FAF1(3), JUN(2), LMNA(2), LMNB1(1), LMNB2(3), MAP2K4(5), MAP3K1(5), MAP3K7(7), MAPK8(4), PAK1(2), PAK2(3), PRKDC(18), PTPN13(10), RB1(6), RIPK2(1), SPTAN1(8) 8617336 95 41 94 31 13 35 21 8 18 0 0.36 0.70 316 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(3), ASNS(4), ASRGL1(1), CA1(1), CA13(1), CA14(1), CA3(1), CA4(2), CA5B(1), CA6(2), CA7(1), CA9(2), CPS1(8), CTH(2), GLS(4), GLS2(4), GLUD1(3), GLUD2(3), GLUL(2) 4214238 46 26 46 14 4 22 11 4 5 0 0.36 0.71 317 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASS(1), ACAT1(2), ACAT2(1), AKR1B10(1), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), BBOX1(1), DOT1L(8), EHHADH(1), EHMT2(2), GCDH(3), HADH(2), HADHA(2), HSD17B4(2), HSD3B7(1), NSD1(9), OGDH(7), OGDHL(3), PIPOX(2), PLOD1(5), PLOD2(3), PLOD3(4), RDH11(1), RDH12(1), SETD1A(7), SETDB1(11), SHMT1(1), SHMT2(2), SPCS3(1), SUV39H1(4), SUV39H2(1), TMLHE(3) 11834739 107 46 104 32 23 33 22 13 16 0 0.36 0.71 318 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(1), CALM1(1), CALM2(2), CALM3(1), EGFR(7), ELK1(2), GNAQ(1), GRB2(1), JUN(2), MAP2K1(3), MAP2K2(1), MAP2K4(5), MAP3K1(5), MAPK1(2), MAPK3(1), MAPK8(4), MEF2B(2), MEF2C(1), MEF2D(3), PAK1(2), PTK2(5), PTK2B(8), RAF1(6), SHC1(3), SOS1(3) 6817181 73 36 73 24 17 28 17 3 8 0 0.37 0.71 319 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(11), EP300(10), ESR1(4), MAPK1(2), MAPK3(1), PELP1(5) 3018169 33 20 32 6 8 10 3 1 11 0 0.37 0.71 320 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1R(6), C1S(3), C2(2), C3(11), C5(7), C6(7), C7(2), C8A(3), C9(3) 3617068 45 24 44 11 9 16 9 4 5 2 0.37 0.71 321 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(7), MAP2K1(3), MAP3K1(5), MAPK14(1), NCOR2(12), RARA(1), RXRA(2), THRA(1), THRB(4) 3581158 40 25 40 19 9 18 7 1 5 0 0.37 0.72 322 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(2), ADC(1), ALDH4A1(2), ALDH5A1(3), CAD(4), CPS1(8), EARS2(2), EPRS(3), GAD1(3), GAD2(3), GCLM(2), GFPT1(3), GFPT2(1), GLS(4), GLS2(4), GLUD1(3), GLUD2(3), GLUL(2), GMPS(3), GOT1(2), GOT2(2), GPT(1), GPT2(3), GSR(4), GSS(1), NADSYN1(3), PPAT(1), QARS(4) 7931455 77 39 76 31 23 27 17 6 4 0 0.38 0.72 323 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(1), B3GNT2(1), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), FUT1(1), FUT4(1), FUT7(1), FUT9(1), GCNT2(2), ST3GAL6(2), ST8SIA1(3) 3322606 28 23 27 11 6 11 7 3 1 0 0.38 0.73 324 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(5), JAK2(4), JAK3(3), MAPK1(2), MAPK3(1), STAT3(4), TYK2(4) 2438023 23 18 23 10 6 9 2 1 3 2 0.38 0.73 325 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(3), AKT1(2), AKT2(1), AKT3(3), DAG1(7), GNAQ(1), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), PDK1(1), PHKA2(4), PIK3CB(4), PITX2(2), PLD1(6), PLD2(10), PLD3(5), VN1R1(3) 9210782 107 41 107 37 21 44 20 10 10 2 0.39 0.73 326 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(1), CBS(3), CTH(2), GGT1(7), LCMT1(1), LCMT2(4), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), METTL6(1), PAPSS1(4), PAPSS2(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), SCLY(1), SEPHS1(1), SEPHS2(1), WBSCR22(1) 5052404 44 29 43 16 10 12 9 5 8 0 0.39 0.74 327 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(14), ACACB(11), ACAT1(2), ACAT2(1), ACOT12(3), ACSS1(6), ACSS2(2), ACYP2(1), AKR1B1(3), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), DLAT(6), DLD(2), GRHPR(2), HAGH(2), LDHAL6B(1), LDHB(2), LDHC(1), LDHD(1), MDH1(1), ME1(3), ME2(4), ME3(4), PC(3), PCK1(3), PCK2(4), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2) 9396184 109 43 109 30 24 42 22 7 14 0 0.39 0.74 328 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(6), ACY3(1), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH3B2(3), ALDH9A1(3), AOC2(4), AOC3(2), CARM1(1), CNDP1(1), DDC(3), HARS(4), HARS2(2), HDC(3), HNMT(1), LCMT1(1), LCMT2(4), MAOA(1), MAOB(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), PRPS1(1), PRPS2(3), UROC1(1), WBSCR22(1) 8006999 69 37 68 17 16 23 15 7 6 2 0.40 0.75 329 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(1), CASP2(2), CASP3(1), CASP8(3), DFFA(2), DFFB(2), JUN(2), LMNA(2), LMNB1(1), LMNB2(3), MADD(3), MAP2K4(5), MAP3K1(5), MAP3K7(7), MAPK8(4), PAK1(2), PAK2(3), PRKDC(18), RB1(6), SPTAN1(8), TNF(1), TNFRSF1A(3), TRAF2(2) 8117389 86 40 85 30 14 36 17 5 14 0 0.40 0.75 330 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), CASP8(3), CYCS(1), MAP2K1(3), MAP2K4(5), MAP3K1(5), MAPK1(2), MAPK3(1), MAPK8(4), NFKB1(4), NSMAF(6), RAF1(6), RELA(2), SMPD1(3), TNFRSF1A(3), TRAF2(2) 4206790 51 27 51 17 13 18 7 4 9 0 0.40 0.75 331 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(3), ADCY1(9), ADCY2(5), ADCY3(2), ADCY4(4), ADCY5(7), ADCY6(5), ADCY7(8), ADCY8(8), ADK(1), ADSL(4), AK5(2), ALLC(2), AMPD1(2), AMPD2(5), AMPD3(5), ATIC(3), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), CANT1(4), DGUOK(1), ENPP1(1), ENPP3(3), ENTPD1(1), FHIT(1), GART(4), GDA(1), GMPS(3), GUCY1A2(3), GUCY1A3(7), GUCY1B3(4), GUCY2C(1), GUCY2D(5), GUCY2F(5), GUK1(2), IMPDH1(1), NPR1(6), NPR2(2), NUDT2(1), PAPSS1(4), PAPSS2(2), PDE1A(2), PDE4A(4), PDE4B(4), PDE4C(2), PDE5A(5), PDE6B(7), PDE6C(2), PDE7B(2), PDE8A(5), PDE9A(5), PFAS(2), PKLR(4), PKM2(2), POLD1(4), POLG(1), POLL(1), POLQ(11), POLR1B(2), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(8), PPAT(1), PRPS1(1), PRPS1L1(1), PRPS2(3), PRUNE(2), RRM1(4), RRM2(1) 26283992 242 66 241 97 65 78 63 21 15 0 0.40 0.75 332 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(7), AMY2A(1), AMY2B(2), ENPP1(1), ENPP3(3), GAA(2), GANAB(2), GBA3(1), GBE1(3), GCK(2), GPI(4), GUSB(1), GYS1(4), GYS2(2), HK1(5), HK2(3), HK3(2), MGAM(4), PGM1(2), PGM3(5), PYGB(4), PYGL(4), PYGM(6), SI(9), UCHL1(1), UCHL3(3), UGDH(1), UGT1A5(1), UGT2B15(1), UGT2B4(2), UXS1(1) 11359929 89 43 89 34 22 27 21 5 14 0 0.40 0.75 333 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(2), BAD(1), CASP1(2), CASP10(2), CASP2(2), CASP3(1), CASP4(2), CASP7(2), CASP8(3), CASP9(1), CD40(1), CD40LG(3), CYCS(1), DAXX(3), DFFA(2), DFFB(2), FAS(1), IKBKE(2), LTA(1), NFKB1(4), NGFR(2), NR3C1(3), NTRK1(3), PTPN13(10), SFRS2IP(4), TNF(1), TNFRSF1A(3), TRAF2(2), TRAF3(2), TRAF6(3) 9025646 71 38 71 34 17 21 17 8 8 0 0.40 0.75 334 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AKR1C1(1), AKR1C3(1), AKR1C4(1), ALDH3A1(4), ALDH3B2(3), CYP1A1(1), CYP1A2(3), CYP1B1(1), CYP2B6(1), CYP2C18(4), CYP2C19(4), CYP2C9(1), CYP2E1(3), CYP2F1(1), CYP2S1(3), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), DHDH(4), EPHX1(3), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(1), GSTP1(1), GSTT1(1), GSTT2(1), GSTZ1(1), MGST1(1), MGST2(1), MGST3(1), UGT1A5(1), UGT2A1(2), UGT2A3(4), UGT2B10(2), UGT2B11(1), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(2) 11138750 102 42 101 29 22 31 23 14 12 0 0.41 0.75 335 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(1), FUT9(1), HEXA(1), HEXB(2), NAGA(3), ST3GAL1(3), ST3GAL2(3), ST3GAL4(1), ST8SIA1(3) 2053653 18 16 18 6 9 4 3 1 1 0 0.41 0.75 336 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(4), AGT(1), AGTR1(1), AGTR2(1), BDKRB2(2), KNG1(2), NOS3(2), REN(3) 2067086 16 14 16 9 3 6 3 1 3 0 0.42 0.76 337 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(2), BCAT2(1), COASY(1), DPYD(12), DPYS(1), ENPP1(1), ENPP3(3), ILVBL(2), PANK1(1), PANK2(2), PANK4(2), PPCDC(1), UPB1(2), VNN1(1) 3535672 32 20 32 4 7 8 10 3 4 0 0.42 0.76 338 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), SHMT1(1) 3032267 30 21 30 10 7 9 9 3 2 0 0.42 0.76 339 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), SHMT1(1) 3032267 30 21 30 10 7 9 9 3 2 0 0.42 0.76 340 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), SHMT1(1) 3032267 30 21 30 10 7 9 9 3 2 0 0.42 0.76 341 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1), CHRNA1(3), SNAP25(1), STX1A(1) 649705 6 6 6 3 4 0 2 0 0 0 0.42 0.76 342 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT1(2), GOT2(2), TAT(1), TYR(1) 938049 9 9 9 3 3 5 0 1 0 0 0.42 0.76 343 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(2), BHMT(5), CBS(3), CTH(2), DNMT1(10), DNMT3A(5), DNMT3B(4), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), MTR(4), SRM(1), TAT(1) 4214637 43 25 43 29 6 22 8 4 3 0 0.43 0.77 344 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(2), ACTN2(11), ACTN3(1), CAPN1(1), CAPNS1(1), ITGA1(4), ITGB1(2), ITGB3(5), PTK2(5), PXN(2), SPTAN1(8), TLN1(9) 5816489 52 31 52 29 16 17 9 5 5 0 0.43 0.78 345 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(3), MTMR1(2), MTMR2(1), MTMR6(3), NFS1(2), PHPT1(3), THTPA(1), TPK1(2) 1285977 17 12 17 2 6 3 6 1 1 0 0.43 0.78 346 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 2 FAH(2), GSTZ1(1) 263872 3 3 3 0 0 3 0 0 0 0 0.44 0.78 347 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(4), ALDOC(2), TPI1(1) 774725 8 8 8 2 2 5 1 0 0 0 0.44 0.78 348 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), ELK1(2), FPR1(1), GNA15(2), GNB1(1), GNGT1(2), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAP3K1(5), MAPK1(2), MAPK14(1), MAPK3(1), NCF1(1), NFATC2(5), NFATC3(3), NFATC4(9), NFKB1(4), PAK1(2), PIK3C2G(3), PLCB1(8), PPP3CA(2), PPP3CB(1), RAF1(6), RELA(2) 7873866 78 37 78 25 16 26 17 7 12 0 0.44 0.79 349 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2G(3), CAMK4(2), CAMKK1(2), CREB1(4) 2374183 22 16 22 8 4 9 4 2 3 0 0.45 0.79 350 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), DAB1(4), FYN(3), LRP8(1), RELN(15), VLDLR(3) 2806034 28 19 28 17 12 6 4 2 4 0 0.45 0.79 351 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 DAXX(3), EGF(4), EGFR(7), ETS1(3), ETS2(1), HOXA7(2), IKBKB(3), JUN(2), MAP2K1(3), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(8), MAP3K1(5), MAP3K14(1), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), NFKB1(4), PPP2CA(1), PRKCD(2), PRKCE(3), PRKCG(4), PRKCH(2), PRKCQ(1), RAF1(6), RELA(2), SP1(2), TNF(1), TNFRSF1A(3), TRAF2(2) 10037643 92 41 91 41 19 43 11 5 14 0 0.45 0.80 352 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 14 NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(4), NDUFS2(2), NDUFV1(1) 1362851 12 11 12 4 1 3 4 2 2 0 0.46 0.80 353 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(2), ADSL(4), AGXT(1), AGXT2(4), ASL(4), ASNS(4), CAD(4), CRAT(1), DARS(1), DDO(2), GAD1(3), GAD2(3), GOT1(2), GOT2(2), GPT(1), GPT2(3), NARS(1), PC(3) 5272652 47 29 46 21 13 21 7 5 1 0 0.46 0.80 354 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), IL6(1), LDLR(3), LPL(1) 1064399 7 7 7 3 1 0 1 2 3 0 0.46 0.80 355 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(1), JUN(2), MAP2K1(3), MAPK1(2), MAPK3(1), NFKB1(4), PLCB1(8), RAF1(6), RELA(2), TNF(1) 3131618 30 21 30 10 5 11 7 2 5 0 0.46 0.80 356 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNA1(1), IFNB1(2), IKBKB(3), IL1B(1), IL1R1(2), IL1RAP(3), IL6(1), IRAK1(4), IRAK2(4), IRAK3(2), JUN(2), MAP2K3(1), MAP2K6(2), MAP3K1(5), MAP3K14(1), MAP3K7(7), MAPK14(1), MAPK8(4), MYD88(2), NFKB1(4), RELA(2), TGFB1(2), TGFB2(4), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(3) 6023304 68 32 67 22 15 26 15 4 8 0 0.47 0.80 357 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(3), ALDH1A2(4), BCMO1(1), RDH5(1) 775124 9 8 9 5 4 3 1 0 1 0 0.47 0.80 358 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CBS(3), CTH(2), MUT(3) 996702 9 9 9 7 0 3 2 1 3 0 0.47 0.80 359 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 FH(1), IDH2(1), MDH1(1), OGDH(7), SDHA(4), SUCLA2(3) 1880753 17 14 16 6 3 6 3 1 4 0 0.47 0.80 360 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(3), ASNS(4), CA1(1), CA14(1), CA3(1), CA4(2), CA5B(1), CA6(2), CA7(1), CA9(2), CPS1(8), CTH(2), GLS(4), GLS2(4), GLUD1(3), GLUL(2) 3755521 41 23 41 13 4 18 10 4 5 0 0.47 0.80 361 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 27 CCR1(1), CCR2(1), CCR3(3), CD4(3), CXCR4(2), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(1), IL12RB1(3), IL12RB2(3), IL18R1(2), IL2(1), TGFB1(2), TGFB2(4), TGFB3(3) 3811514 34 21 34 17 4 12 10 2 6 0 0.47 0.80 362 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CDC34(1), CDK2(2), CUL1(5), RB1(6), SKP2(2) 1762383 18 14 17 3 1 5 8 2 2 0 0.47 0.80 363 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(14), ACAT1(2), ACAT2(1), ACYP2(1), ADH5(1), AKR1B1(3), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), DLAT(6), DLD(2), GRHPR(2), HAGH(2), LDHB(2), LDHC(1), LDHD(1), MDH1(1), ME1(3), ME2(4), ME3(4), PC(3), PCK1(3), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2) 7432705 90 38 90 24 17 35 21 6 11 0 0.48 0.81 364 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(2), CCNB1(1), CCND2(1), CCND3(2), CCNH(2), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(2), CDKN2D(1), RB1(6), RBL1(3) 3209955 29 21 28 9 7 10 8 1 3 0 0.48 0.81 365 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(11), EP300(10), LPL(1), NCOA1(7), NCOA2(10), PPARG(1), RXRA(2) 3710833 42 23 42 10 13 12 6 2 9 0 0.48 0.81 366 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25A(2), CDC25B(4), CDC25C(2), CSK(2), GRB2(1), PTPRA(4) 1870113 16 14 16 3 2 6 4 0 4 0 0.49 0.82 367 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(3), CD8A(1), CSF3(1), IL11(1), IL2(1), IL3(1), IL6(1), IL8(1) 1268554 10 9 10 6 1 5 2 1 1 0 0.49 0.83 368 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), CYCS(1), GPD2(2), NDUFA1(1), SDHA(4), SDHB(3), SDHC(1), UQCRC1(2) 1319626 15 12 15 4 5 5 3 0 2 0 0.49 0.83 369 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(2), IARS(6), LARS(2), LARS2(1), PDHA1(1), PDHA2(4), PDHB(2) 2008566 18 16 18 5 1 9 5 0 3 0 0.50 0.83 370 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), HMOX1(3), IL10(1), IL10RA(1), IL10RB(1), IL6(1), JAK1(5), STAT1(3), STAT3(4), TNF(1) 2455180 22 16 22 6 4 10 3 2 1 2 0.50 0.84 371 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(6), ATP4A(5), ATP4B(1), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), COX10(1), COX15(3), COX4I1(3), COX4I2(1), COX6B1(1), COX7A2(2), COX7C(1), LHPP(3), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA3(1), NDUFA8(1), NDUFA9(2), NDUFB2(1), NDUFB7(1), NDUFB8(1), NDUFC2(2), NDUFS1(4), NDUFS2(2), NDUFS5(1), NDUFS6(1), NDUFS8(1), NDUFV1(1), PPA2(1), SDHA(4), SDHB(3), SDHC(1), TCIRG1(2), UQCRB(1), UQCRC1(2), UQCRC2(1), UQCRQ(1) 11292764 102 43 102 46 29 30 27 8 8 0 0.50 0.84 372 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1R(6), C1S(3), C2(2), C3(11), C5(7), C6(7), C7(2), C8A(3), C8B(4), C9(3), MASP1(3) 4273157 52 26 51 11 11 18 11 4 6 2 0.51 0.84 373 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(2), TAT(1) 525084 5 5 5 3 1 4 0 0 0 0 0.51 0.85 374 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(2), CALM3(1), DLG4(4), GRIN1(3), GRIN2A(7), GRIN2B(9), GRIN2C(2), GRIN2D(1), NOS1(15), PPP3CA(2), PPP3CB(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5) 5138854 60 32 60 20 23 20 6 4 7 0 0.51 0.85 375 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(6), ARHGEF1(1), GNA12(1), GNAQ(1), GNB1(1), GNGT1(2), MYL2(1), MYLK(7), PLCB1(8), PPP1R12B(2), ROCK1(5) 4161836 35 24 35 20 8 10 6 1 8 2 0.52 0.85 376 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(8), DLD(2), FH(1), IDH1(1), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), OGDHL(3), PC(3), PCK1(3), PCK2(4), SDHA(4), SDHB(3), SDHC(1), SUCLA2(3), SUCLG1(2), SUCLG2(3) 5987261 56 31 54 22 10 24 10 4 8 0 0.52 0.85 377 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1R(6), C1S(3), C2(2), C3(11), C5(7), C6(7), C7(2), C8A(3), C9(3), MASP1(3), MASP2(2), MBL2(1) 4382217 51 25 50 12 11 19 10 4 5 2 0.52 0.85 378 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(11), DUSP1(1), EP300(10), IKBKB(3), IL1B(1), IL8(1), MAP2K3(1), MAP2K6(2), MAP3K14(1), MAP3K7(7), MAPK14(1), MYD88(2), NFKB1(4), NR3C1(3), RELA(2), TGFBR1(1), TGFBR2(4), TLR2(2), TNF(1) 6029555 58 30 58 15 14 15 12 5 12 0 0.52 0.85 379 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT5(2), DPM1(1), FUT8(2), MAN1B1(1), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), RPN1(1), RPN2(2) 4038944 32 24 31 19 9 10 8 1 4 0 0.53 0.85 380 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(8), FH(1), IDH1(1), IDH2(1), MDH1(1), SDHB(3), SUCLA2(3) 1777412 18 13 17 3 1 11 3 1 2 0 0.53 0.85 381 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP2(3), ACP5(2), ACP6(3), ACPP(3), ACPT(1), ALPI(3), ALPL(2), ALPP(3), ALPPL2(4), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), DHRS7(1), PON2(2) 3534608 34 22 33 13 8 13 3 4 6 0 0.53 0.85 382 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(2), IL12B(1), IL2(1) 599963 6 6 6 1 1 1 4 0 0 0 0.53 0.85 383 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), CHPT1(1), LCMT1(1), LCMT2(4), METTL6(1), PCYT1A(6), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), WBSCR22(1) 2862692 24 19 24 7 7 7 5 1 4 0 0.53 0.85 384 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(5), CREB1(4), DAXX(3), ELK1(2), GRB2(1), IKBKB(3), JUN(2), MAP2K1(3), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K5(1), MAP2K6(2), MAP2K7(8), MAP3K1(5), MAP3K10(5), MAP3K11(3), MAP3K12(3), MAP3K13(2), MAP3K14(1), MAP3K2(2), MAP3K3(1), MAP3K4(5), MAP3K6(5), MAP3K7(7), MAP3K9(3), MAP4K1(2), MAP4K2(3), MAP4K3(2), MAP4K4(4), MAP4K5(4), MAPK1(2), MAPK10(3), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(3), MAPK6(1), MAPK7(8), MAPK8(4), MAPK9(1), MAPKAPK3(3), MAPKAPK5(1), MEF2B(2), MEF2C(1), MEF2D(3), MKNK1(1), NFKB1(4), PAK1(2), PAK2(3), RAF1(6), RELA(2), RPS6KA1(2), RPS6KA2(6), RPS6KA4(2), RPS6KB1(2), RPS6KB2(2), SHC1(3), SP1(2), STAT1(3), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TRAF2(2) 19867274 185 51 183 64 45 72 27 12 29 0 0.53 0.85 385 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2B(1), ADORA3(2), LTB4R(2), P2RY1(3) 1196335 12 10 12 3 6 3 2 0 1 0 0.53 0.85 386 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), UGDH(1) 1731660 15 14 15 1 4 6 4 0 1 0 0.54 0.85 387 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(3), CASP8(3), TNF(1), TNFRSF1A(3), TRAF2(2) 1753073 13 12 13 4 5 3 2 1 2 0 0.54 0.86 388 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(15), B3GALT4(1), CDR1(2), DGKI(5), IL6ST(1), RPL10(1), RPL12(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL22(10), RPL27A(1), RPL3(1), RPL31(1), RPL36(1), RPL5(1), RPL6(1), RPL9(2), RPLP0(2), RPS10(1), RPS11(1), RPS13(1), RPS14(1), RPS23(1), RPS27A(1), RPS3A(1), RPS5(1), RPS6(1), RPS6KA1(2), RPS6KA2(6), RPS6KA6(6), RPS6KB1(2), RPS6KB2(2), RPSA(4), SLC36A2(3), TBC1D10C(1), TSPAN9(1), UBC(3) 10756375 90 42 81 33 21 24 21 6 18 0 0.54 0.86 389 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(3), ALAS2(4), CPOX(1), FECH(3), UROS(3) 1543066 14 13 14 6 5 5 1 2 1 0 0.54 0.86 390 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(5), AGT(1), AGTR1(1), AGTR2(1), COL4A1(5), COL4A2(4), COL4A3(3), COL4A4(4), COL4A5(2), COL4A6(5), REN(3) 5174099 34 26 34 16 11 9 6 5 3 0 0.55 0.86 391 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(13), RANGAP1(4) 1679923 18 13 18 13 1 7 4 5 1 0 0.55 0.86 392 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(1), IL13RA2(4), JAK1(5), JAK2(4), TYK2(4) 2104725 19 13 19 11 3 6 3 2 3 2 0.55 0.86 393 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(1), IL13RA2(4), JAK1(5), JAK2(4), TYK2(4) 2104725 19 13 19 11 3 6 3 2 3 2 0.55 0.86 394 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 16 CALM1(1), CALM2(2), CALM3(1), CXCR4(2), GNAQ(1), JUN(2), MAPK14(1), MAPK8(4), PLCG1(9), PTK2B(8) 2644838 31 20 30 8 12 13 5 0 1 0 0.55 0.86 395 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), FDXR(1), SHMT1(1) 3226314 31 21 31 11 7 9 9 3 3 0 0.55 0.86 396 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), IL22RA1(1), IL22RA2(1), JAK1(5), JAK2(4), JAK3(3), SOCS3(2), STAT1(3), STAT3(4), STAT5B(4), TYK2(4) 3790101 32 22 32 11 7 14 3 1 5 2 0.55 0.86 397 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), EHHADH(1), HADHA(2), SDS(1) 2460367 25 19 24 6 8 9 4 0 4 0 0.55 0.86 398 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(7), DDX20(3), ETS1(3), ETS2(1), HDAC2(3), HDAC5(3), JUN(2), NCOR2(12), RBL1(3), RBL2(1), SIN3A(4), SIN3B(5) 5431587 47 27 47 22 9 25 7 2 4 0 0.55 0.86 399 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(5), EPHB1(9), FYN(3), ITGA1(4), ITGB1(2), L1CAM(3), LYN(2), RAP1B(2), SELP(2) 3156755 33 20 33 23 6 15 6 4 2 0 0.56 0.86 400 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(4), ALDOC(2), FBP2(3), GOT1(2), GOT2(2), GPT(1), GPT2(3), MDH1(1), ME1(3), ME2(4), ME3(4), PGK1(1), PKLR(4), PKM2(2), TPI1(1) 3544450 37 24 36 14 10 18 6 1 2 0 0.56 0.86 401 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(2), ACAA2(1), ACADM(1), ACAT1(2), ACAT2(1), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH6A1(1), ALDH9A1(3), AOX1(3), AUH(5), BCAT1(2), BCAT2(1), BCKDHA(3), DBT(2), DLD(2), EHHADH(1), HADH(2), HADHA(2), HADHB(2), HIBADH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(2), IVD(1), MCCC1(1), MCCC2(2), MCEE(2), MUT(3), OXCT1(2), PCCA(7), PCCB(2) 8707510 73 32 70 24 17 20 14 4 16 2 0.57 0.86 402 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(2), IL13(1), MAF(1), MAP2K3(1), MAPK14(1), NFATC2(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5) 2436427 23 18 23 9 7 9 3 4 0 0 0.57 0.86 403 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(3), GALNT2(2), GALNT3(1), GALNT4(1), GALNT6(1), GALNT8(3), GCNT1(1), ST3GAL1(3), ST3GAL2(3), ST3GAL4(1), WBSCR17(7) 2879849 28 21 28 7 11 7 6 2 2 0 0.57 0.86 404 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(4), PLCB1(8), RELA(2) 1670613 15 11 15 6 2 4 4 1 4 0 0.57 0.86 405 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(4), GRB2(1), HBXIP(1), PTK2B(8), SHC1(3), SOS1(3) 1784727 20 14 20 5 5 7 3 1 4 0 0.57 0.86 406 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(4), PAPSS2(2), SULT1A2(4), SULT1E1(1), SULT2A1(1) 1215088 14 10 14 3 3 6 4 0 1 0 0.57 0.86 407 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 14 CD2(2), CD3E(1), CD3G(2), CD4(3), IFNG(2), IL12B(1), IL12RB1(3), IL12RB2(3), JAK2(4), STAT4(4), TYK2(4) 2861761 29 19 28 14 1 13 7 1 7 0 0.57 0.87 408 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(16), CDC25A(2), CDC25B(4), CDC25C(2), CHEK1(2), WEE1(1) 2771587 27 18 26 3 5 7 9 0 4 2 0.58 0.87 409 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(4), FARSA(2), FARSB(1), GOT1(2), GOT2(2), PAH(4), TAT(1), YARS2(1) 1755068 17 14 17 10 2 11 3 0 1 0 0.58 0.87 410 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(3), PDXK(3), PDXP(1), PNPO(1) 976087 8 7 8 2 0 2 1 1 2 2 0.58 0.87 411 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP2(3), MMP9(5), RECK(4), TIMP3(2) 1517530 14 11 14 10 2 7 2 0 3 0 0.58 0.87 412 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(6), DLD(2), FH(1), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), PC(3), PDHA1(1), PDHA2(4), PDHB(2), PDHX(1), PDK1(1), PDK3(2), PDP2(1), SDHA(4), SDHB(3), SDHC(1), SUCLA2(3), SUCLG1(2), SUCLG2(3) 5737354 53 31 52 28 10 20 13 2 8 0 0.59 0.88 413 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), FUCA1(1), FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(10), MAN2B1(7), MAN2B2(6), MAN2C1(3), MANBA(1), NEU1(1), NEU2(2), NEU3(1) 4184446 42 23 42 20 8 17 5 7 5 0 0.59 0.88 414 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(2), CDC25B(4), CDKN1A(1), CHEK1(2), NEK1(4), WEE1(1) 1479226 14 12 14 3 3 2 3 2 4 0 0.59 0.88 415 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(3), HDAC9(1), MEF2B(2), MEF2C(1), MEF2D(3), MYOD1(3) 1660904 14 14 14 6 3 8 2 1 0 0 0.60 0.88 416 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS7(1), ESCO2(1), MYST3(6), MYST4(12), NAT6(1), PNPLA3(1), SH3GLB1(1) 3204768 23 20 23 5 4 6 8 2 3 0 0.60 0.88 417 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 17 B3GAT1(2), B3GAT3(2), B4GALT7(1), CHPF(2), CHST11(1), CHST12(5), CHST13(1), CHST3(1), CHST7(1), DSE(6), UST(3), XYLT1(5), XYLT2(3) 3011785 33 21 33 9 6 13 10 2 2 0 0.60 0.89 418 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(6), EIF2AK4(4), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF5(2), GSK3B(1), PPP1CA(2) 2346918 22 18 22 7 4 8 6 3 1 0 0.60 0.89 419 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1), LIPT1(2) 304437 3 3 3 2 1 1 0 0 1 0 0.61 0.89 420 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(5), LCT(10), PGM1(2), PYGL(4), PYGM(6), TPI1(1), TREH(4) 2700299 32 19 32 9 11 12 3 2 4 0 0.61 0.89 421 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(1), ATG7(3), GABARAPL1(2), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(1), IFNA6(1), IFNA7(2), IFNA8(1), IFNG(2), PIK3C3(4), PIK3R4(7), PRKAA1(1), PRKAA2(2), ULK1(1), ULK2(2), ULK3(1) 4273157 39 23 39 17 10 5 14 3 7 0 0.61 0.89 422 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 CREB1(4), JUN(2), KEAP1(4), MAPK1(2), MAPK14(1), MAPK8(4), NFE2L2(1) 1781003 18 15 18 6 6 9 1 1 1 0 0.62 0.90 423 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(2), C1GALT1(1), C1GALT1C1(3), GALNT1(2), GALNT10(3), GALNT11(3), GALNT12(1), GALNT13(3), GALNT14(5), GALNT2(2), GALNT3(1), GALNT4(1), GALNT5(3), GALNT6(1), GALNT8(3), GALNTL1(2), GALNTL2(4), GALNTL4(4), GALNTL5(4), GCNT1(1), GCNT3(2), GCNT4(1), OGT(2), ST3GAL1(3), ST3GAL2(3), ST6GALNAC1(1), WBSCR17(7) 6502769 68 33 67 25 17 26 17 5 3 0 0.62 0.90 424 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(2), ALPP(3), ALPPL2(4) 1370698 12 10 11 6 1 8 0 2 1 0 0.62 0.90 425 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 58 ATP12A(6), ATP4B(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), ATP7B(10), COX10(1), COX4I1(3), COX6B1(1), COX7A2(2), COX7C(1), NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(4), NDUFS2(2), NDUFV1(1), PPA2(1), SDHA(4), SDHB(3), SHMT1(1), UQCRB(1), UQCRC1(2) 7025459 78 35 78 22 17 25 23 5 8 0 0.62 0.90 426 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(2), ARFGAP1(1), ARFGAP3(3), ARFGEF2(9), CLTA(2), COPA(1), GBF1(8), GPLD1(6) 3263554 32 22 32 10 10 9 8 4 1 0 0.62 0.90 427 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO3(2), FARS2(4), GOT1(2), GOT2(2), PAH(4), TAT(1) 1652525 17 14 17 9 3 12 1 0 1 0 0.62 0.90 428 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(3), CHAT(1), COMT(1), DBH(2), DDC(3), GAD1(3), GAD2(3), HDC(3), MAOA(1), PAH(4), PNMT(2), TH(1) 2972550 28 21 28 10 7 14 3 2 2 0 0.63 0.90 429 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1), IL8(1) 340613 2 2 2 2 0 2 0 0 0 0 0.63 0.90 430 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(3), ALAS2(4), CPO(1), FECH(3), GATA1(1), UROS(3) 1651195 15 13 15 7 5 5 1 3 1 0 0.63 0.91 431 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(4), ELK1(2), GRB2(1), IL6(1), IL6ST(1), JAK1(5), JAK2(4), JAK3(3), JUN(2), MAP2K1(3), MAPK3(1), PTPN11(3), RAF1(6), SHC1(3), SOS1(3), SRF(1), STAT3(4) 4898390 47 27 47 16 14 16 7 5 3 2 0.64 0.91 432 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), AGT(1), AGTR2(1), EDN1(2), EDNRA(2), EDNRB(10), EGF(4), EGFR(7), JUN(2), NFKB1(4), PLCG1(9), RELA(2) 4155053 46 24 44 17 14 17 6 1 8 0 0.64 0.92 433 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(4), GREB1(8), HSPB1(1), HSPB2(1), MTA1(4), PDZK1(2), TUBA8(3) 2279088 24 16 24 8 4 10 4 1 5 0 0.65 0.92 434 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(3), CYP11A1(2), CYP11B2(2), CYP17A1(1), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1) 1390382 13 11 13 4 5 4 1 3 0 0 0.65 0.92 435 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ABAT(2), ACAT1(2), ACAT2(1), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH5A1(3), ALDH9A1(3), EHHADH(1), GAD1(3), GAD2(3), HADHA(2), HMGCL(1), OXCT1(2), PDHA1(1), PDHA2(4), PDHB(2), SDHB(3), SDS(1) 5205487 54 29 53 21 15 23 8 2 6 0 0.65 0.92 436 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(3), ALG10B(1), ALG13(1), ALG3(2), ALG9(1), B4GALT1(2), B4GALT2(5), B4GALT3(1), DOLPP1(1), DPM1(1), FUT8(2), GANAB(2), MAN1A2(1), MAN1B1(1), MAN1C1(3), MAN2A1(6), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), MGAT5B(2), RFT1(1), RPN1(1), RPN2(2), STT3B(4) 8660960 58 35 57 26 15 16 14 2 11 0 0.65 0.92 437 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(1), ARSE(3), ASAH1(1), CERK(3), DEGS1(1), DEGS2(2), ENPP7(4), GAL3ST1(3), GALC(4), GBA(2), GLB1(2), LCT(10), NEU1(1), NEU2(2), NEU3(1), PPAP2C(4), SGMS1(2), SMPD1(3), SMPD3(4), SMPD4(3), SPHK1(4), SPTLC2(2), UGT8(2) 7343063 65 36 65 31 20 26 9 7 3 0 0.65 0.92 438 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(3), GGPS1(2), SQLE(3) 877667 8 6 7 2 1 2 1 1 3 0 0.65 0.92 439 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDK2(2), CUL1(5), NEDD8(1), RB1(6), SKP2(2) 1754669 16 12 15 1 1 4 6 2 3 0 0.66 0.92 440 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(8), DLD(2), FH(1), IDH1(1), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(1), MDH1(1), PC(3), PCK1(3), SDHA(4), SDHB(3), SUCLA2(3), SUCLG1(2), SUCLG2(3) 4140822 39 24 38 15 5 20 7 2 5 0 0.66 0.92 441 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(1), CAPN2(3), CAPNS1(1), EGF(4), EGFR(7), ITGA1(4), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(1), MYLK(7), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PTK2(5), PXN(2), TLN1(9) 6610366 62 33 62 30 20 23 6 5 8 0 0.66 0.92 442 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CCNA2(1), CCNE2(1), CDK2(2), CDKN2A(2), PRB1(1) 1757462 9 9 9 9 2 0 5 1 1 0 0.66 0.92 443 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(3), CTH(2), GOT1(2), GOT2(2), LDHB(2), LDHC(1), MPST(1) 1374954 13 11 13 3 2 7 3 0 1 0 0.67 0.93 444 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2G(3), CAMK4(2), HDAC5(3), MEF2B(2), MEF2C(1), MEF2D(3), PPARA(2), PPP3CA(2), PPP3CB(1), SLC2A4(1) 4141620 31 23 31 10 8 13 6 1 3 0 0.68 0.93 445 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(6), AP2A1(1), AP2M1(5), CALM1(1), CALM2(2), CALM3(1), DNM1(4), EPN1(3), PICALM(1), PPP3CA(2), PPP3CB(1), SYNJ1(5), SYNJ2(13) 4521335 45 25 42 10 11 18 7 3 6 0 0.68 0.93 446 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(2), BAK1(1), BID(1), BIRC2(1), BIRC3(3), CASP3(1), CASP7(2), CASP8(3), CASP9(1), CYCS(1), DFFA(2), DFFB(2), DIABLO(1), ENDOG(1) 2756957 22 18 22 4 4 7 5 2 4 0 0.68 0.93 447 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(1), CASP8(3), CFL1(1) 775922 5 5 5 2 0 3 0 0 2 0 0.68 0.93 448 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 57 AADAT(1), AANAT(1), ABP1(6), ACAT1(2), ACAT2(1), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), AOC2(4), AOC3(2), AOX1(3), CARM1(1), CAT(4), CYP1A1(1), CYP1A2(3), CYP1B1(1), DDC(3), EHHADH(1), GCDH(3), HADH(2), HADHA(2), HSD17B4(2), INMT(1), KYNU(4), LCMT1(1), LCMT2(4), LNX1(1), MAOA(1), MAOB(2), METTL6(1), NFX1(2), OGDH(7), OGDHL(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), TDO2(1), TPH2(3), WARS(3), WARS2(4), WBSCR22(1) 12112177 105 44 101 29 23 31 20 9 18 4 0.68 0.93 449 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(2), BIRC2(1), BIRC3(3), CASP1(2), CASP10(2), CASP2(2), CASP3(1), CASP4(2), CASP7(2), CASP8(3), CASP9(1), CYCS(1), DFFA(2), DFFB(2), LMNA(2), LMNB1(1), LMNB2(3), PRF1(1) 3910333 33 23 33 10 8 9 7 5 4 0 0.68 0.93 450 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(1), IL13(1), IL16(2), IL2(1), IL3(1), IL6(1), IL8(1), LTA(1), TNF(1) 1975316 16 13 16 9 0 7 9 0 0 0 0.68 0.93 451 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(4), EGFR(7), RAB5A(2), TF(5), TFRC(1) 2599618 21 16 21 11 4 8 4 1 4 0 0.69 0.93 452 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(7), AMY2A(1), AMY2B(2), ASCC3(14), ATP13A2(6), DDX18(7), DDX19A(2), DDX23(2), DDX4(1), DDX41(5), DDX47(2), DDX50(2), DDX54(5), DDX55(3), DDX56(4), DHX58(4), ENPP1(1), ENPP3(3), ENTPD7(6), EP400(2), ERCC2(3), ERCC3(3), GAA(2), GANC(3), GBA(2), GBA3(1), GBE1(3), GCK(2), GPI(4), GUSB(1), GYS1(4), GYS2(2), HK1(5), HK2(3), HK3(2), IFIH1(3), LYZL1(2), MGAM(4), NUDT5(1), NUDT8(1), PGM1(2), PGM3(5), PYGB(4), PYGL(4), PYGM(6), RAD54B(2), RAD54L(4), RUVBL2(2), SETX(8), SI(9), SKIV2L2(3), SMARCA2(13), SMARCA5(1), TREH(4), UGDH(1), UGP2(1), UGT1A5(1), UGT2A1(2), UGT2A3(4), UGT2B10(2), UGT2B11(1), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(2), UXS1(1) 24781092 217 60 215 74 50 69 45 21 32 0 0.69 0.93 453 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT3(2), AGPAT4(4), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(2), ENPP6(1), PAFAH1B1(3), PAFAH1B2(2), PAFAH1B3(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLD1(6), PLD2(10), PPAP2C(4) 4707136 55 28 55 14 9 27 11 3 5 0 0.69 0.93 454 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS1(6), ACSS2(2), ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH3B2(3), ALDH9A1(3), ALDOB(4), ALDOC(2), BPGM(1), DLAT(6), DLD(2), ENO1(2), ENO3(2), FBP2(3), GALM(1), GAPDH(1), GCK(2), GPI(4), HK1(5), HK2(3), HK3(2), LDHAL6B(1), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKL(6), PFKM(1), PFKP(7), PGAM2(2), PGK1(1), PGK2(1), PGM1(2), PGM3(5), PKLR(4), PKM2(2), TPI1(1) 11509554 132 44 131 45 37 52 22 10 11 0 0.69 0.93 455 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(11), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(2), ACSL6(4), ADIPOQ(2), ADIPOR1(1), ADIPOR2(2), AKT1(2), AKT2(1), AKT3(3), CAMKK1(2), CD36(1), CPT1A(2), CPT1C(2), CPT2(3), IKBKB(3), IRS1(5), IRS2(3), IRS4(9), JAK1(5), JAK2(4), JAK3(3), LEPR(7), MAPK10(3), MAPK8(4), MAPK9(1), NFKB1(4), NFKB2(2), NFKBIB(3), NPY(1), PCK1(3), PCK2(4), POMC(5), PPARA(2), PPARGC1A(5), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(1), PRKAG2(2), PRKAG3(2), PRKCQ(1), PTPN11(3), RELA(2), RXRA(2), RXRG(2), SLC2A1(3), SLC2A4(1), SOCS3(2), STAT3(4), TNF(1), TNFRSF1A(3), TRAF2(2), TYK2(4) 16985164 160 51 160 67 36 70 20 8 24 2 0.69 0.93 456 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(3), GCK(2), GFPT1(3), GNE(1), GNPDA1(3), GNPDA2(1), HEXA(1), HEXB(2), HK1(5), HK2(3), HK3(2), PGM3(5) 3425415 31 23 31 11 13 10 6 1 1 0 0.69 0.93 457 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(6), ACTR2(2), AKT1(2), ANGPTL2(3), CDC42(1), CFL1(1), FLNA(5), FLNC(18), FSCN1(4), FSCN3(6), GDI1(1), LIMK1(2), MYH2(9), MYLK(7), MYLK2(2), PAK1(2), PAK2(3), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PFN2(2), RHO(1), ROCK1(5), ROCK2(2), VASP(2), WASF1(3), WASL(1) 9799174 98 38 98 39 33 28 21 9 7 0 0.69 0.93 458 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(1), CASP7(2), DFFA(2), DFFB(2), ENDOG(1), HMGB2(2), TOP2A(3), TOP2B(8) 2033836 21 13 19 4 1 6 6 1 7 0 0.69 0.93 459 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(3), HDC(3), PNMT(2), TH(1) 1237698 11 9 11 5 2 5 3 1 0 0 0.70 0.93 460 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), CDC42(1), CREB1(4), CREB3(3), CREB5(2), DUSP1(1), DUSP10(2), EEF2K(6), EIF4E(1), ELK1(2), HSPB1(1), IL1R1(2), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K10(5), MAP3K4(5), MAP3K7(7), MAPK1(2), MAPK13(1), MAPK14(1), MAPKAPK5(1), MKNK1(1), MYEF2(3), NFKB1(4), NR2C2(3), SRF(1), TRAF6(3) 6868652 72 33 71 22 11 34 13 3 11 0 0.70 0.94 461 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), FUCA1(1), FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(10), MAN2C1(3), MANBA(1), NEU1(1), NEU2(2), NEU3(1) 3403603 29 18 29 17 6 9 4 5 5 0 0.70 0.94 462 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(2) 378385 4 3 4 2 0 2 2 0 0 0 0.71 0.94 463 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(1), AKT3(3), ARHGEF11(8), CDC42(1), DLG4(4), LPA(6), MAP2K4(5), MAP3K1(5), MAPK8(4), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), PDK1(1), PHKA2(4), PI3(2), PIK3CB(4), PLD1(6), PLD2(10), PLD3(5), PTK2(5), RDX(1), ROCK1(5), ROCK2(2), SERPINA4(1), SRF(1), TBXA2R(6) 9997078 107 41 107 36 21 48 21 6 11 0 0.71 0.94 464 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 IL1B(1), MST1(2), MST1R(7), TNF(1) 1331729 11 10 11 1 4 4 1 1 1 0 0.72 0.95 465 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX15(2), ALOX5(2), CYP1A2(3), CYP2C18(4), CYP2C19(4), CYP2C9(1), CYP2E1(3), CYP2J2(2), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), HSD3B7(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), RDH11(1), RDH12(1) 4813935 48 27 48 12 10 19 10 5 4 0 0.72 0.96 466 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(4), AASS(1), ACAT1(2), ACAT2(1), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), BBOX1(1), DOT1L(8), EHHADH(1), EHMT2(2), GCDH(3), HADHA(2), PLOD1(5), PLOD2(3), PLOD3(4), SDS(1), SHMT1(1), SHMT2(2), TMLHE(3) 7546420 66 33 65 21 15 20 17 3 11 0 0.72 0.96 467 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(1), IFNAR1(2), IFNAR2(3), IFNB1(2), MAPK8(4), NFKB1(4), RELA(2), TNFRSF11A(4), TNFSF11(1), TRAF6(3) 2251690 26 17 26 8 6 8 6 2 4 0 0.72 0.96 468 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDPS(3), HMGCR(4), MVD(1), MVK(3), NQO1(3), NQO2(2), SC5DL(1), SQLE(3), VKORC1(1) 2295713 23 16 23 8 5 10 3 3 2 0 0.73 0.96 469 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(2), BID(1), BIRC2(1), BIRC3(3), CASP10(2), CASP3(1), CASP7(2), CASP8(3), CASP9(1), CYCS(1), DFFA(2), DFFB(2), LMNA(2), MAP3K14(1), NFKB1(4), RELA(2), SPTAN1(8), TNFRSF10A(2), TNFRSF10B(1), TNFRSF25(2), TNFSF10(2), TRAF2(2) 6839924 47 31 47 17 10 16 6 6 9 0 0.73 0.96 470 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(11), EP300(10), HDAC3(3), IKBKB(3), NFKB1(4), RELA(2), TNF(1), TNFRSF1A(3), TRAF6(3) 4571210 40 23 40 13 11 11 6 2 10 0 0.73 0.96 471 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP2(3), ACP5(2), ACP6(3), ACPP(3), ACPT(1), ENPP1(1), ENPP3(3), FLAD1(1), LHPP(3), MTMR1(2), MTMR2(1), MTMR6(3), PHPT1(3), RFK(1), TYR(1) 3012317 31 18 31 4 9 8 8 4 2 0 0.74 0.96 472 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(2), COQ6(2), NDUFA13(1) 833245 6 6 6 3 2 3 1 0 0 0 0.74 0.97 473 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADL(1), ACADM(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH6A1(1), ALDH9A1(3), AOX1(3), BCAT1(2), BCKDHA(3), EHHADH(1), HADHA(2), HADHB(2), HIBADH(1), HMGCL(1), IVD(1), MCCC1(1), MCCC2(2), MCEE(2), MUT(3), OXCT1(2), PCCA(7), PCCB(2), SDS(1) 7238126 66 29 63 24 14 22 11 4 13 2 0.75 0.97 474 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(14), ACACB(11), AKT1(2), AKT2(1), AKT3(3), ARAF(6), BAD(1), BRAF(5), CALM1(1), CALM2(2), CALM3(1), CBL(1), CBLB(2), CBLC(2), CRK(1), EIF4EBP1(1), ELK1(2), EXOC7(4), FASN(3), FBP2(3), FLOT1(1), FLOT2(3), FOXO1(1), GCK(2), GRB2(1), GSK3B(1), GYS1(4), GYS2(2), IKBKB(3), INPP5D(1), INSR(7), IRS1(5), IRS2(3), IRS4(9), KRAS(7), LIPE(1), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(1), MKNK1(1), PCK1(3), PCK2(4), PDE3A(3), PDE3B(9), PDPK1(1), PFKL(6), PFKM(1), PFKP(7), PHKA1(4), PHKA2(4), PHKB(3), PHKG1(2), PHKG2(2), PIK3CA(23), PIK3CB(4), PIK3CD(6), PIK3CG(9), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(4), PKLR(4), PKM2(2), PPARGC1A(5), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R3A(9), PPP1R3B(1), PPP1R3C(3), PPP1R3D(2), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKAG1(1), PRKAG2(2), PRKAG3(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), PRKCI(4), PRKX(1), PTPRF(6), PYGB(4), PYGL(4), PYGM(6), RAF1(6), RAPGEF1(6), RHEB(1), RPS6(1), RPS6KB1(2), RPS6KB2(2), SH2B2(3), SHC1(3), SHC2(2), SHC3(3), SHC4(1), SLC2A4(1), SOCS2(2), SOCS3(2), SOCS4(1), SORBS1(5), SOS1(3), SOS2(4), SREBF1(3), TRIP10(6), TSC1(1), TSC2(3) 32922820 377 75 363 133 89 140 79 24 45 0 0.75 0.97 475 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH3B2(3), ALDH9A1(3), ALDOB(4), ALDOC(2), BPGM(1), DLAT(6), DLD(2), ENO1(2), ENO3(2), FBP2(3), GAPDH(1), GCK(2), GPI(4), HK1(5), HK2(3), HK3(2), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(1), PFKP(7), PGK1(1), PGM1(2), PGM3(5), PKLR(4), PKM2(2), TPI1(1) 9693705 119 41 118 42 29 48 21 10 11 0 0.75 0.97 476 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH3B2(3), ALDH9A1(3), ALDOB(4), ALDOC(2), BPGM(1), DLAT(6), DLD(2), ENO1(2), ENO3(2), FBP2(3), GAPDH(1), GCK(2), GPI(4), HK1(5), HK2(3), HK3(2), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(1), PFKP(7), PGK1(1), PGM1(2), PGM3(5), PKLR(4), PKM2(2), TPI1(1) 9693705 119 41 118 42 29 48 21 10 11 0 0.75 0.97 477 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 19 CD3E(1), CD3G(2), ETV5(4), IFNG(2), IL12B(1), IL12RB1(3), IL12RB2(3), IL18R1(2), JAK2(4), JUN(2), MAP2K6(2), MAPK14(1), MAPK8(4), STAT4(4), TYK2(4) 3651249 39 21 38 12 5 15 8 2 9 0 0.75 0.97 478 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(1), BRAF(5), CREB1(4), CREB3(3), CREB5(2), DUSP6(1), DUSP9(2), EEF2K(6), EIF4E(1), GRB2(1), MAP2K1(3), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(1), MOS(3), NFKB1(4), RAP1A(1), RPS6KA1(2), RPS6KA2(6), SHC1(3), SOS1(3), SOS2(4), TRAF3(2) 6059081 62 30 61 18 14 24 12 4 8 0 0.75 0.97 479 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(4), ALDOC(2), FBP2(3), GOT1(2), GOT2(2), GPT(1), GPT2(3), MDH1(1), ME1(3), ME3(4), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TKTL1(4), TKTL2(3), TPI1(1) 3966193 41 24 40 15 12 20 4 4 1 0 0.76 0.97 480 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(3), SQLE(3) 662872 6 4 6 2 1 2 1 1 1 0 0.77 0.98 481 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(2), ABAT(2), ACAT1(2), ACAT2(1), ACSM1(1), AKR1B10(1), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH5A1(3), ALDH9A1(3), DDHD1(5), EHHADH(1), GAD1(3), GAD2(3), HADH(2), HADHA(2), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(2), HSD3B7(1), ILVBL(2), OXCT1(2), PDHA1(1), PDHA2(4), PDHB(2), PRDX6(1), RDH11(1), RDH12(1) 8272733 64 36 62 25 20 24 10 4 6 0 0.77 0.98 482 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP2(3), ACP5(2), ACPP(3), ACPT(1), ALPI(3), ALPL(2), ALPP(3), ALPPL2(4), CYP19A1(4), CYP1A1(1), CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(4), CYP2C19(4), CYP2C9(1), CYP2D6(2), CYP2E1(3), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A5(1), CYP3A7(2), CYP4F8(1), CYP51A1(2) 5930470 62 31 61 16 19 23 9 6 5 0 0.77 0.99 483 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 COPS5(2), CREB1(4), EDN1(2), EP300(10), HIF1A(1), JUN(2), NOS3(2), P4HB(1) 3423952 24 20 24 7 6 6 5 1 6 0 0.77 0.99 484 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(2), IFNGR2(1), JAK1(5), JAK2(4), STAT1(3) 1646673 17 10 17 6 4 6 2 1 2 2 0.78 0.99 485 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(2), ACACA(14), ACADL(1), ACADM(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH6A1(1), ALDH9A1(3), EHHADH(1), HADHA(2), LDHB(2), LDHC(1), MCEE(2), MLYCD(2), MUT(3), PCCA(7), PCCB(2), SDS(1), SUCLA2(3), SUCLG1(2), SUCLG2(3) 6633641 76 30 73 20 19 23 13 5 16 0 0.78 0.99 486 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(2), UBE2A(1), UBE2B(1), UBE2D3(1), UBE2E3(3), UBE2G2(1), UBE2H(1), UBE2I(2), UBE2J2(3), UBE2L6(1), UBE2N(1), UBE3A(3) 2127734 21 15 21 13 6 8 2 2 3 0 0.78 0.99 487 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), GRB2(1), IL2RG(2), IRS1(5), JAK1(5), JAK3(3), RPS6KB1(2), SHC1(3) 3042508 23 17 22 15 7 4 5 1 4 2 0.79 0.99 488 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(1), FURIN(2), NOTCH1(9), PSEN1(1) 1987020 14 12 14 17 2 9 1 1 1 0 0.79 0.99 489 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(1), CHST12(5), CHST13(1), PAPSS1(4), PAPSS2(2), SULT1A1(2), SULT1A2(4), SULT1E1(1), SULT2A1(1) 1901102 23 13 23 7 6 9 6 0 2 0 0.79 0.99 490 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(6), ADCY3(2), ADCY9(4), ARF1(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1C1(1), ATP6V1C2(3), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1H(1), GNAS(12), PLCG1(9), PLCG2(5), SEC61B(1), SEC61G(1), TRIM23(2) 7479787 64 32 62 25 16 27 10 6 5 0 0.79 0.99 491 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), CD36(1), FYN(3), JUN(2), MAPK14(1), THBS1(5) 1482684 13 12 13 3 6 3 2 1 1 0 0.79 0.99 492 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), ACAT2(1), HMGCL(1), OXCT1(2) 673911 6 5 6 4 2 2 0 1 1 0 0.79 0.99 493 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(2), CALM3(1), CDKN1A(1), GNAQ(1), MARCKS(2), NFATC2(5), NFATC3(3), NFATC4(9), PLCG1(9), PPP3CA(2), PPP3CB(1), SP1(2), SP3(2) 4252542 41 23 39 11 15 11 10 0 5 0 0.79 0.99 494 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), FUT1(1), FUT9(1), GCNT2(2), ST8SIA1(3) 1270416 8 7 8 1 2 3 1 2 0 0 0.80 0.99 495 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(4), AGPAT6(1), CDS1(2), CDS2(1), CHAT(1), CHKA(1), CHPT1(1), DGKA(1), DGKB(3), DGKE(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), ESCO2(1), ETNK2(2), GNPAT(1), GPAM(4), GPD1(2), GPD1L(3), GPD2(2), LCAT(1), LYPLA2(1), MYST3(6), MYST4(12), NAT6(1), PCYT1A(6), PEMT(1), PISD(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(1), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLD1(6), PLD2(10), PNPLA3(1), PPAP2C(4), PTDSS1(1), SH3GLB1(1) 13520514 122 45 122 35 29 48 26 8 11 0 0.80 0.99 496 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(13), ANAPC2(3), ANAPC4(2), ANAPC5(2), ANAPC7(1), BTRC(2), CDC20(2), CDC23(4), CDC26(1), CDC27(1), CUL1(5), CUL2(4), CUL3(2), FBXW11(4), FBXW7(8), FZR1(3), ITCH(2), SKP2(2), SMURF1(1), UBE2D3(1), UBE2E3(3), WWP1(6), WWP2(9) 8206366 81 36 71 20 18 24 21 5 13 0 0.80 0.99 497 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(5), COL4A2(4), COL4A3(3), COL4A4(4), COL4A5(2), COL4A6(5), P4HB(1), SLC23A1(5), SLC23A2(5), SLC2A1(3), SLC2A3(1) 5127682 38 24 38 19 11 11 4 5 7 0 0.80 0.99 498 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(2), IKBKB(3), JUN(2), LTA(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K1(5), MAP3K14(1), MAP4K2(3), MAPK14(1), MAPK8(4), NFKB1(4), RELA(2), TANK(1), TNF(1), TNFRSF1A(3), TRAF2(2) 5004923 43 25 43 15 10 17 5 5 6 0 0.80 0.99 499 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), ARG1(1), GLS(4), GLUD1(3) 1080359 10 7 10 4 3 3 3 0 1 0 0.80 0.99 500 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(5), GRB2(1), IL3(1), JAK2(4), MAP2K1(3), MAPK3(1), RAF1(6), SHC1(3), SOS1(3), STAT5B(4) 3419031 31 19 31 10 6 13 6 2 4 0 0.80 0.99 501 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CCNH(2), CDC25A(2), CDC25B(4), CDC25C(2), MNAT1(2), XPO1(2) 1775550 15 10 15 3 1 6 4 0 4 0 0.80 0.99 502 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(1), CALM1(1), CALM2(2), CALM3(1), CD79A(5), ELK1(2), GRB2(1), JUN(2), LYN(2), MAP2K1(3), MAP3K1(5), MAPK14(1), MAPK3(1), MAPK8(4), NFATC2(5), NFATC3(3), NFATC4(9), PLCG1(9), PPP3CA(2), PPP3CB(1), RAF1(6), SHC1(3), SOS1(3), SYK(1), VAV1(2) 7736876 76 34 74 25 26 24 17 2 7 0 0.81 0.99 503 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GLB1(2), GNS(3), GUSB(1), HEXA(1), HEXB(2), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(4), IDS(3), LCT(10), SPAM1(2) 4206657 38 24 37 15 5 19 9 4 1 0 0.81 0.99 504 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(5), HK2(3), HK3(2), IMPA1(2), PGM1(2), PGM3(5), TGDS(2) 2059505 23 16 23 10 9 9 3 0 2 0 0.81 0.99 505 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(3), GPLD1(6), PGAP1(3), PIGA(2), PIGB(3), PIGC(1), PIGG(5), PIGL(1), PIGM(4), PIGN(2), PIGO(1), PIGQ(1), PIGS(1), PIGT(3), PIGV(2), PIGX(2), PIGZ(2) 4953718 42 26 42 10 12 14 9 3 4 0 0.81 0.99 506 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1), EPHX2(4), HSD3B7(1), RDH11(1), RDH12(1) 978614 8 7 8 3 4 3 0 1 0 0 0.81 0.99 507 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(2), CHIT1(2), CMAS(3), CTBS(2), GFPT1(3), GFPT2(1), GNE(1), GNPDA1(3), GNPDA2(1), HEXA(1), HEXB(2), HK1(5), HK2(3), HK3(2), LHPP(3), MTMR1(2), MTMR2(1), MTMR6(3), NPL(1), PGM3(5), PHPT1(3) 5795475 50 30 50 16 19 13 14 3 1 0 0.81 0.99 508 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GLB1(2), GNS(3), GUSB(1), HEXA(1), HEXB(2), IDS(3), LCT(10) 2959649 23 17 23 12 5 7 7 3 1 0 0.81 0.99 509 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP2(3), ACP5(2), ACPP(3), ACPT(1), ENPP1(1), ENPP3(3), FLAD1(1), RFK(1), TYR(1) 1937544 16 11 16 3 3 5 4 2 2 0 0.82 0.99 510 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(2), CRY1(1), CRY2(2), CSNK1E(5), PER1(3) 1746556 15 11 15 4 4 5 0 4 2 0 0.82 0.99 511 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ARHGAP4(1), ARHGAP5(6), ARHGAP6(3), ARHGEF1(1), ARHGEF11(8), ARHGEF5(5), ARPC1A(1), ARPC1B(1), ARPC4(1), CFL1(1), DIAPH1(3), GSN(4), LIMK1(2), MYL2(1), MYLK(7), OPHN1(6), PIP5K1A(2), PPP1R12B(2), ROCK1(5), TLN1(9), VCL(2) 9397514 73 34 73 33 19 28 10 5 9 2 0.82 0.99 512 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), MDH1(1), ME1(3), PC(3), PDHA1(1), SLC25A1(2) 1874635 12 10 12 7 0 7 3 1 1 0 0.83 0.99 513 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(7), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(9), POLR3B(5), POLR3G(1) 4701683 39 25 39 13 6 19 6 5 3 0 0.83 1.00 514 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNAR2(3), IFNB1(2), JAK1(5), STAT1(3), STAT2(1), TYK2(4) 2170959 21 12 21 8 3 7 5 1 3 2 0.83 1.00 515 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(8), GRHPR(2), HAO1(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1) 2562112 17 14 16 12 2 8 2 3 2 0 0.83 1.00 516 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(1), BIRC3(3), CASP3(1), CASP8(3), JUN(2), MAP2K4(5), MAP3K3(1), MAP3K7(7), NFKB1(4), NFKB2(2), NFKBIB(3), NFKBIL2(6), NR2C2(3), RALBP1(7), TNF(1), TNFAIP3(4), TNFRSF1A(3), TRAF2(2) 5596507 59 27 59 10 13 22 11 3 10 0 0.84 1.00 517 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(1), TGDS(2), UGDH(1), UXS1(1) 801857 6 5 6 3 2 1 2 0 1 0 0.84 1.00 518 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(14), ACACB(11), FASN(3), OXSM(2) 3309572 30 17 30 9 7 8 3 3 9 0 0.84 1.00 519 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(1), FUCA1(1), FUCA2(2), GBA(2), GLB1(2), GNS(3), GUSB(1), HEXA(1), HEXB(2), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(4), IDS(3), LCT(10), MAN2B1(7), MAN2B2(6), MAN2C1(3), MANBA(1), NEU1(1), NEU2(2), NEU3(1), SPAM1(2) 7115899 67 32 66 27 9 32 11 10 5 0 0.84 1.00 520 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(1) 325052 2 2 2 0 2 0 0 0 0 0 0.85 1.00 521 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 CARM1(1), DHRS7(1), LCMT1(1), LCMT2(4), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), WBSCR22(1) 2906582 18 15 18 7 5 4 4 1 4 0 0.85 1.00 522 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(4), ELK1(2), EPOR(2), GRB2(1), JAK2(4), JUN(2), MAP2K1(3), MAPK3(1), MAPK8(4), PLCG1(9), RAF1(6), SHC1(3), SOS1(3), STAT5B(4) 4379424 48 24 47 10 14 20 6 3 5 0 0.85 1.00 523 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ACAT2(1), ACYP2(1), EHHADH(1), GCDH(3), HADHA(2), SDHB(3), SDS(1) 1579508 14 10 13 2 2 4 3 2 3 0 0.85 1.00 524 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), DHCR7(2), FDPS(3), HMGCR(4), HMGCS1(1), MVD(1), MVK(3), NSDHL(3), SC4MOL(2), SC5DL(1), SQLE(3) 2714530 25 16 25 8 8 7 5 3 2 0 0.85 1.00 525 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(14), CPT1A(2), LEPR(7), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(1), PRKAG2(2) 2904321 31 17 31 9 6 10 5 3 7 0 0.85 1.00 526 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAP3K14(1), MAPK14(1), MAPK8(4), NFKB1(4), RELA(2), TNFRSF13B(1), TNFRSF17(1), TRAF2(2), TRAF3(2), TRAF6(3) 2969890 21 16 21 8 10 5 2 1 3 0 0.85 1.00 527 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(4), ELK1(2), GRB2(1), IL2(1), IL2RA(1), IL2RG(2), JAK1(5), JAK3(3), JUN(2), LCK(1), MAP2K1(3), MAPK3(1), MAPK8(4), RAF1(6), SHC1(3), SOS1(3), STAT5B(4), SYK(1) 4803428 47 24 46 11 13 14 8 4 6 2 0.85 1.00 528 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(5), HK2(3), HK3(2), IMPA1(2), ISYNA1(2), PGM1(2), PGM3(5), TGDS(2) 2372720 25 17 25 13 10 9 3 1 2 0 0.86 1.00 529 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(2), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1) 1812923 16 12 16 6 5 7 2 2 0 0 0.86 1.00 530 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(2), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1) 1812923 16 12 16 6 5 7 2 2 0 0 0.86 1.00 531 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(3), CD38(2), ENPP1(1), ENPP3(3), NADK(2), NADSYN1(3), NMNAT1(1), NMNAT3(1), NNMT(1), NNT(6), NT5C1A(1), NT5C1B(3), NT5C2(4), NUDT12(1) 4365060 32 21 32 18 10 7 6 4 3 2 0.86 1.00 532 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(2), CAMK2G(3), DAG1(7), ITPKA(1), ITPKB(4), ITPR1(13), ITPR2(12), ITPR3(10), NFAT5(5), PDE6A(1), PDE6B(7), PDE6C(2), TF(5) 7333620 73 30 73 30 13 26 17 3 12 2 0.86 1.00 533 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ACOT11(2), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), CYP2C19(4), CYP2C9(1), DHRS7(1), EHHADH(1), ESCO2(1), HADHA(2), MYST3(6), MYST4(12), NAT6(1), PNPLA3(1), SH3GLB1(1), YOD1(2) 6125714 49 28 48 10 12 14 13 4 6 0 0.87 1.00 534 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(4), ALDOC(2), DLAT(6), DLD(2), ENO1(2), ENO3(2), FBP2(3), GAPDH(1), GCK(2), GOT1(2), GOT2(2), GPI(4), HK1(5), HK2(3), HK3(2), LDHAL6B(1), LDHB(2), LDHC(1), MDH1(1), PC(3), PCK1(3), PDHA1(1), PDHA2(4), PDHB(2), PDHX(1), PFKL(6), PFKM(1), PFKP(7), PGAM2(2), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TNFAIP1(3), TPI1(1) 8432998 89 36 89 39 26 44 11 4 4 0 0.87 1.00 535 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(2), CDK2(2), DIAPH2(3), MCM10(2), MCM2(9), MCM3(3), MCM4(4), MCM5(3), MCM6(1), MCM7(3), NACA(1), ORC1L(9), ORC2L(1), ORC3L(4), ORC4L(2), ORC6L(1), PCNA(2), POLA2(1), POLD1(4), POLD3(2), POLE2(1), PRIM1(1), RFC1(1), RFC2(1), RFC3(4), RFC4(1), RPA1(1), RPA2(1), RPA3(1), RPS27A(1), UBC(3) 10370010 77 36 76 30 10 26 17 6 18 0 0.87 1.00 536 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(8), GRHPR(2), HAO1(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1) 2684206 17 14 16 12 2 8 2 3 2 0 0.87 1.00 537 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(3), ARG1(1), ASL(4), CKMT1A(1), CKMT2(2), CPS1(8), GATM(1), GLUD1(3), NAGS(1), ODC1(3), OTC(1), SMS(2) 3506678 30 19 30 8 7 10 11 1 1 0 0.88 1.00 538 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), CLOCK(2), CRY1(1), CRY2(2), DAZAP2(2), DNAJA1(1), EIF4G2(1), ETV6(3), G0S2(1), GFRA1(4), GSTM3(1), GSTP1(1), HERPUD1(1), HSPA8(3), KLF9(1), MYF6(1), NCKAP1(4), NR1D2(3), PER1(3), PER2(6), PPP1R3C(3), PSMA4(3), PURA(1), SF3A3(2), TOB1(1), UCP3(2), UGP2(1), ZFR(5) 7434035 61 33 61 20 12 21 16 8 4 0 0.88 1.00 539 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), TGM2(4) 1022371 6 6 6 4 3 3 0 0 0 0 0.89 1.00 540 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACAT1(2), ACAT2(1), ACOT11(2), ACYP2(1), DHRS7(1), EHHADH(1), ESCO2(1), GCDH(3), HADHA(2), ITGB1BP3(3), MYST3(6), MYST4(12), NAT6(1), PNPLA3(1), SH3GLB1(1), YOD1(2) 5115712 40 25 39 8 6 10 12 5 7 0 0.89 1.00 541 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(2), ALPP(3), ALPPL2(4), ASCC3(14), ATP13A2(6), DDX18(7), DDX19A(2), DDX23(2), DDX4(1), DDX41(5), DDX47(2), DDX50(2), DDX54(5), DDX55(3), DDX56(4), DHX58(4), ENTPD7(6), EP400(2), ERCC2(3), ERCC3(3), IFIH1(3), NUDT5(1), NUDT8(1), QDPR(3), RAD54B(2), RAD54L(4), RUVBL2(2), SETX(8), SKIV2L2(3), SMARCA2(13), SMARCA5(1) 12847002 124 42 121 40 25 49 20 12 18 0 0.89 1.00 542 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(1), TGDS(2), UGDH(1), UGP2(1), UXS1(1) 1010268 7 6 7 4 2 2 2 0 1 0 0.89 1.00 543 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(2), CRY1(1), CRY2(2), CSNK1E(5), NPAS2(4), NR1D1(1), PER1(3), PER2(6), PER3(5) 3475290 31 18 31 11 5 11 5 5 5 0 0.89 1.00 544 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), CREBBP(11), CTBP1(2), CTBP2(2), DLL1(1), DLL3(1), DLL4(1), DTX1(7), DTX2(1), DTX3L(1), DTX4(3), DVL1(3), DVL2(2), DVL3(3), EP300(10), HDAC1(2), HDAC2(3), JAG1(3), JAG2(1), MAML1(4), MAML2(6), MAML3(7), NCOR2(12), NCSTN(2), NOTCH1(9), NOTCH2(9), NOTCH3(8), NOTCH4(6), NUMB(2), NUMBL(3), PSEN1(1), PSEN2(1), PSENEN(1), PTCRA(1), RBPJ(1), RBPJL(1) 14493010 132 42 128 63 33 45 20 12 22 0 0.89 1.00 545 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(1), ARSD(1), ARSE(3), ASAH1(1), GAL3ST1(3), GALC(4), GBA(2), GLB1(2), LCT(10), NEU1(1), NEU2(2), NEU3(1), PPAP2C(4), SMPD1(3), SPTLC2(2) 4961698 41 25 41 25 9 18 6 6 2 0 0.89 1.00 546 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CDC42(1), CREB1(4), DAXX(3), DDIT3(3), ELK1(2), GRB2(1), HSPB1(1), HSPB2(1), MAP2K4(5), MAP2K6(2), MAP3K1(5), MAP3K7(7), MAP3K9(3), MAPK14(1), MAPKAPK5(1), MEF2B(2), MEF2C(1), MEF2D(3), MKNK1(1), PLA2G4A(3), SHC1(3), STAT1(3), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR1(1), TRAF2(2) 7469280 68 30 68 25 16 26 13 4 9 0 0.89 1.00 547 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(3), ALAS2(4), BLVRA(2), COX10(1), COX15(3), CP(5), CPOX(1), EARS2(2), EPRS(3), FECH(3), FTH1(1), FTMT(1), GUSB(1), HCCS(1), HMOX1(3), UGT1A5(1), UGT2A1(2), UGT2A3(4), UGT2B10(2), UGT2B11(1), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(2), UROS(3) 8082011 54 31 54 27 15 19 10 6 4 0 0.90 1.00 548 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(3), CYP2E1(3), PTGS1(4), PTGS2(1) 1058813 11 7 11 6 4 5 1 1 0 0 0.90 1.00 549 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(2), BCAT2(1), IARS(6), IARS2(3), ILVBL(2), LARS(2), LARS2(1), PDHA1(1), PDHA2(4), PDHB(2), VARS(5), VARS2(3) 3763900 32 20 32 10 6 14 8 0 4 0 0.90 1.00 550 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(3), CD38(2), ENPP1(1), ENPP3(3), NADSYN1(3), NMNAT1(1), NNMT(1), NNT(6) 2942758 20 15 20 13 5 4 4 3 2 2 0.90 1.00 551 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADM(1), ACAT1(2), HADHA(2) 1097383 6 6 5 1 0 0 1 2 3 0 0.90 1.00 552 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(2), RAB27A(2), RAB5A(2), RAB6A(1) 865298 8 5 8 10 2 2 4 0 0 0 0.91 1.00 553 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADL(1), ACADM(1), ACADSB(2), ACAT1(2), ACAT2(1), ACOX1(2), ACOX3(4), ACSL1(2), ACSL3(3), ACSL4(1), ACSL5(2), ACSL6(4), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), CPT1A(2), CPT1C(2), CPT2(3), CYP4A22(1), EHHADH(1), GCDH(3), HADH(2), HADHA(2), HADHB(2), HSD17B4(2) 9838010 83 33 81 17 15 26 15 10 17 0 0.91 1.00 554 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(2), BAD(1), BAK1(1), BCL10(1), BCL2L11(1), BID(1), CASP8AP2(4), CASP9(1), CES1(5) 2318190 17 13 17 9 4 10 1 1 1 0 0.91 1.00 555 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(6), SP1(2), SP3(2) 1340906 10 8 9 4 2 0 7 0 1 0 0.91 1.00 556 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(2), CAPN1(1), CAPNS1(1), CDK5(2), GSK3B(1), MAPT(4), PPP2CA(1) 1928101 12 11 12 11 5 4 2 0 1 0 0.92 1.00 557 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(2), CASP3(1), CASP9(1), CYCS(1), DAXX(3), FAS(1), HSPB1(1), HSPB2(1), MAPKAPK3(3), TNF(1) 2292521 16 13 16 12 7 6 2 0 1 0 0.92 1.00 558 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(2), HLA-DRA(2), HLA-DRB1(1), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(1), IL12RB1(3), IL12RB2(3), IL18R1(2), IL2(1), IL2RA(1) 2553467 21 14 21 10 4 5 7 2 3 0 0.93 1.00 559 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADH(2), HADHA(2), HADHB(2), HSD17B4(2), MECR(2), PPT2(2) 1723414 13 8 12 3 1 3 4 1 4 0 0.93 1.00 560 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 IFNG(2), IKBKB(3), IL2(1), JUN(2), MAP3K1(5), MAP4K5(4), MAPK14(1), MAPK8(4), NFKB1(4), RELA(2), TNFRSF9(3), TRAF2(2) 3993591 33 20 32 9 8 13 6 1 5 0 0.93 1.00 561 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(2), ARHGAP5(6), CASP1(2), CASP10(2), CASP3(1), CASP8(3), CASP9(1), CYCS(1), JUN(2), PRF1(1) 2581397 21 14 21 6 7 6 1 1 4 2 0.93 1.00 562 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 14 ABCA1(4), APOC1(1), APOC2(2), CETP(2), CYP7A1(3), HMGCR(4), LCAT(1), LDLR(3), LIPC(1), LPL(1), LRP1(14), SCARB1(3), SOAT1(4) 5054266 43 23 43 16 12 16 7 4 4 0 0.93 1.00 563 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(5), APOBEC3A(1), APOBEC3B(2), APOBEC3G(1) 1466724 9 8 9 6 4 3 1 1 0 0 0.94 1.00 564 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), B3GALT2(2), B3GNT5(1), FUT1(1), ST3GAL3(2), ST3GAL4(1) 1461005 8 7 8 4 1 6 0 1 0 0 0.94 1.00 565 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(1), CDC40(5), CLK2(2), CLK3(4), CLK4(2), COL2A1(7), CPSF1(8), CPSF2(1), CPSF3(1), CPSF4(2), CSTF1(3), CSTF2(2), CSTF2T(1), CSTF3(2), DDIT3(3), DDX1(3), DDX20(3), DHX15(5), DHX16(4), DHX38(5), DHX8(4), DHX9(1), DICER1(3), DNAJC8(1), METTL3(1), NCBP1(3), NUDT21(1), NXF1(2), PABPN1(1), PAPOLA(2), PHF5A(2), POLR2A(6), PPM1G(3), PRPF3(2), PRPF4(4), PRPF4B(8), PRPF8(7), PSKH1(3), PTBP1(2), PTBP2(1), RBM5(3), RNGTT(1), RNMT(2), RNPS1(1), SF3A1(2), SF3A2(1), SF3A3(2), SF3B1(4), SF3B2(4), SF3B4(3), SF4(3), SFRS12(3), SFRS14(6), SFRS16(2), SFRS4(2), SFRS5(4), SFRS6(5), SFRS7(1), SFRS8(5), SFRS9(1), SNRPA(4), SNRPB(1), SNRPD1(2), SNRPD2(2), SNRPD3(1), SNRPE(1), SNRPG(1), SPOP(2), SRPK1(2), SRPK2(5), SRRM1(3), SUPT5H(3), U2AF1(2), U2AF2(3), XRN2(11) 21322693 219 54 219 65 54 83 36 24 22 0 0.94 1.00 566 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(2), ACACA(14), ACACB(11), ACADM(1), ACAT1(2), ACAT2(1), ACSS1(6), ACSS2(2), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH6A1(1), ALDH9A1(3), EHHADH(1), HADHA(2), LDHAL6B(1), LDHB(2), LDHC(1), MCEE(2), MLYCD(2), MUT(3), PCCA(7), PCCB(2), SUCLA2(3), SUCLG1(2), SUCLG2(3) 7957523 85 31 82 25 23 25 14 4 19 0 0.94 1.00 567 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP19(1), SRP54(2), SRP72(3), SRPR(2) 1504496 9 8 9 4 2 5 1 0 1 0 0.94 1.00 568 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(8) 2797123 22 14 22 10 2 12 4 2 2 0 0.94 1.00 569 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(1), EPOR(2), GRIN1(3), HIF1A(1), JAK2(4), NFKB1(4), RELA(2), SOD2(1) 2579402 18 12 18 8 3 7 1 2 5 0 0.94 1.00 570 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(3), GTF2B(1), GTF2E1(5), GTF2E2(2), GTF2F2(2), GTF2H1(1), MNAT1(2), POLR1A(7), POLR1B(2), POLR2A(6), POLR2B(2), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3B(5), POLR3D(1), POLR3E(1), TAF5(2), TAF6(6), TAF7(4), TBP(2) 7127071 60 29 60 22 17 24 8 3 8 0 0.95 1.00 571 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), ACAT2(1), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(2) 1474837 8 7 8 5 3 2 1 1 1 0 0.95 1.00 572 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 DUSP1(1), IKBKAP(2), IKBKB(3), MAP3K1(5), MAP3K14(1), NFKB1(4), RELA(2), TNFAIP3(4), TRAF3(2), TRAF6(3) 3684632 27 18 27 9 5 13 4 1 4 0 0.95 1.00 573 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 AANAT(1), ABP1(6), ACAT1(2), ACAT2(1), ALDH1A1(3), ALDH1A2(4), ALDH1B1(3), ALDH2(1), ALDH3A1(4), ALDH3A2(3), ALDH9A1(3), AOC2(4), AOC3(2), AOX1(3), CAT(4), CYP19A1(4), CYP1A1(1), CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(4), CYP2C19(4), CYP2C9(1), CYP2D6(2), CYP2E1(3), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A5(1), CYP3A7(2), CYP4F8(1), CYP51A1(2), DDC(3), EHHADH(1), GCDH(3), HADHA(2), KYNU(4), MAOA(1), MAOB(2), SDS(1), TDO2(1), WARS(3), WARS2(4) 10981278 110 39 108 26 31 34 18 9 14 4 0.95 1.00 574 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(4), POLG(1), POLL(1), POLQ(11) 3407460 17 16 17 11 5 6 2 0 4 0 0.95 1.00 575 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), EIF4E(1), FBL(1), GPT(1), LDHB(2), LDHC(1), MAPK14(1), NCL(3) 1804544 13 10 13 2 5 4 3 0 1 0 0.96 1.00 576 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(3), ANKRD1(2), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(2), IL1R1(2) 2231075 13 10 13 7 0 7 5 0 1 0 0.96 1.00 577 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(3), CTH(2), GOT1(2), GOT2(2), LDHAL6B(1), LDHB(2), LDHC(1), MPST(1), SDS(1), SULT1B1(1), SULT4A1(1) 2535778 17 14 17 5 5 7 3 0 2 0 0.96 1.00 578 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(1), AP2M1(5), ARF1(2), BAD(1), BTK(1), EEA1(2), GRASP(1), GSK3B(1), LYN(2), PDPK1(1), PFKL(6), PFKM(1), PFKP(7), PLCG1(9), PRKCE(3), RAB5A(2), RPS6KB1(2), VAV2(5) 5202162 54 23 53 25 12 23 10 6 3 0 0.96 1.00 579 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(4), AASS(1), KARS(2) 1391712 8 7 8 9 1 2 5 0 0 0 0.96 1.00 580 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(3), GUSB(1), UGDH(1), UGP2(1), UGT1A5(1), UGT2A1(2), UGT2A3(4), UGT2B10(2), UGT2B11(1), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(2), XYLB(4) 5035912 27 22 27 13 7 7 7 4 2 0 0.96 1.00 581 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(2), ARSD(1), ARSE(3), CARM1(1), CYP11B1(2), CYP11B2(2), CYP19A1(4), HSD11B1(1), HSD11B2(2), HSD17B1(1), HSD17B12(2), HSD17B2(1), HSD17B3(2), HSD17B7(1), HSD3B1(1), HSD3B2(1), LCMT1(1), LCMT2(4), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(4), SRD5A1(2), SRD5A2(2), STS(3), SULT1E1(1), SULT2A1(1), UGT1A5(1), UGT2A1(2), UGT2A3(4), UGT2B10(2), UGT2B11(1), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(2), WBSCR22(1) 9714719 70 33 70 29 16 24 15 5 10 0 0.97 1.00 582 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(2), CALM3(1), EGR2(3), EGR3(1), GNAQ(1), MAP3K1(5), NFATC2(5), NFKB1(4), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(5), RELA(2) 5578951 49 27 48 20 17 17 9 3 3 0 0.97 1.00 583 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(1), SPCS3(1) 631484 2 2 2 0 0 2 0 0 0 0 0.97 1.00 584 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(3), ALDOB(4), ALDOC(2), FBP2(3), FPGT(2), GCK(2), GMDS(1), GMPPA(3), HK1(5), HK2(3), HK3(2), PFKFB3(2), PFKFB4(1), PFKM(1), PFKP(7), PMM1(1), TPI1(1) 4861549 43 24 43 15 9 24 5 2 3 0 0.97 1.00 585 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), AARS2(4), CARS(3), DARS(1), EARS2(2), EPRS(3), FARS2(4), FARSA(2), FARSB(1), GARS(1), HARS(4), HARS2(2), IARS(6), IARS2(3), KARS(2), LARS(2), LARS2(1), MARS(2), MARS2(1), NARS(1), NARS2(1), QARS(4), RARS(2), RARS2(1), SARS(2), SARS2(1), TARS(3), TARS2(5), VARS(5), VARS2(3), WARS(3), WARS2(4), YARS2(1) 10920630 82 38 81 33 15 43 15 5 4 0 0.97 1.00 586 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), CARS(3), DARS(1), EPRS(3), FARS2(4), GARS(1), HARS(4), IARS(6), KARS(2), LARS(2), LARS2(1), MARS(2), MARS2(1), NARS(1), QARS(4), RARS(2), SARS(2), TARS(3), WARS(3), WARS2(4) 6400226 51 27 50 17 6 30 8 5 2 0 0.97 1.00 587 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(2), ACOX3(4), ELOVL5(1), FADS1(2), FADS2(4), FASN(3), HADHA(2), HSD17B12(2), SCD(4) 3016307 24 14 23 4 8 7 3 0 6 0 0.97 1.00 588 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(4), AGPS(1), CDS1(2), CDS2(1), CHAT(1), CHKA(1), CLC(2), DGKA(1), DGKB(3), DGKE(1), DGKH(8), DGKQ(2), DGKZ(1), GNPAT(1), GPD1(2), GPD2(2), LCAT(1), LYPLA2(1), PAFAH1B1(3), PCYT1A(6), PEMT(1), PISD(2), PLA2G3(5), PLA2G4A(3), PLA2G6(3), PLCB2(3), PLCG1(9), PLCG2(5), PPAP2C(4) 10341415 85 35 84 27 21 39 14 4 7 0 0.97 1.00 589 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR2(2), ARPC1A(1), ARPC1B(1), ARPC4(1), CDC42(1), WASF1(3), WASL(1) 1629516 11 8 11 13 3 4 2 1 1 0 0.97 1.00 590 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 AKR1B10(1), DHRS7(1), HSD3B7(1), PON2(2), RDH11(1), RDH12(1) 1694686 7 7 7 7 2 2 1 1 1 0 0.98 1.00 591 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(3), AKR1B10(1), B4GALT1(2), B4GALT2(5), GAA(2), GALE(1), GALK1(1), GALK2(1), GALT(1), GANC(3), GCK(2), GLB1(2), HK1(5), HK2(3), HK3(2), HSD3B7(1), LALBA(1), LCT(10), MGAM(4), PFKL(6), PFKM(1), PFKP(7), PGM1(2), PGM3(5), RDH11(1), RDH12(1), UGP2(1) 7908180 74 31 73 36 23 30 7 9 5 0 0.98 1.00 592 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(3), BLVRA(2), CP(5), CPOX(1), EPRS(3), FECH(3), GUSB(1), HCCS(1), HMOX1(3), UGT1A5(1), UGT2B15(1), UGT2B4(2), UROS(3) 5247515 29 20 29 17 9 13 1 3 3 0 0.98 1.00 593 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10L(4), RPL12(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL23A(1), RPL27A(1), RPL3(1), RPL31(1), RPL36A(1), RPL6(1), RPL9(2), RPS10(1), RPS11(1), RPS13(1), RPS23(1), RPS3A(1), RPS5(1), RPS6(1), RPSA(4) 4679605 30 21 30 16 8 10 6 2 4 0 0.98 1.00 594 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA3(1), PSMA4(3), PSMA6(2), PSMB2(1), PSMB3(1), PSMB4(1), PSMC2(2), PSMC3(5), PSMD1(3), PSMD12(1), PSMD2(9) 3196123 30 14 30 8 7 7 9 4 3 0 0.98 1.00 595 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(3), POLA2(1), POLD1(4), POLD3(2), POLE2(1), POLE3(1), POLG(1), POLG2(3), POLH(1), POLK(3), POLL(1), POLM(3), POLQ(11), PRIM1(1), PRIM2(3), REV1(3), REV3L(12) 8384320 54 29 54 26 11 16 8 5 14 0 0.98 1.00 596 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(4), ABCC2(11), ABCG2(3), BCHE(3), CES1(5), CES2(3), CYP3A4(1), CYP3A5(1), UGT1A5(1) 4548334 32 18 32 18 8 10 9 0 5 0 0.98 1.00 597 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), ST3GAL3(2) 1044316 3 3 3 3 0 3 0 0 0 0 0.98 1.00 598 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(4), IMPDH1(1), MTHFD2(1), POLD1(4), POLG(1), PRPS2(3), RRM1(4), SRM(1) 2610923 19 11 19 7 4 8 4 2 1 0 0.98 1.00 599 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(2), ARSB(1), ARSD(1), ARSE(3), CYP11B1(2), CYP11B2(2), HSD11B1(1), HSD11B2(2), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1), SRD5A1(2), SRD5A2(2), STS(3), SULT1E1(1), SULT2A1(1), UGT1A5(1), UGT2B15(1), UGT2B4(2) 5276376 33 22 33 14 8 14 4 1 6 0 0.98 1.00 600 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR2(2), ARPC1A(1), ARPC1B(1), ARPC4(1), NCK1(2), NCKAP1(4), NTRK1(3), WASF1(3), WASF2(2), WASF3(3), WASL(1) 3085467 24 14 24 18 3 14 3 2 2 0 0.99 1.00 601 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 EHHADH(1), HADH(2), HADHA(2), HSD17B4(2), NTAN1(2), SIRT1(3), SIRT5(2), VNN2(1) 2356893 15 8 14 8 1 3 5 1 5 0 0.99 1.00 602 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(3), AKR1B10(1), ALDOB(4), ALDOC(2), FBP2(3), FPGT(2), GMDS(1), GMPPA(3), HK1(5), HK2(3), HK3(2), HSD3B7(1), LHPP(3), MTMR1(2), MTMR2(1), MTMR6(3), PFKFB2(5), PFKFB3(2), PFKFB4(1), PFKL(6), PFKM(1), PFKP(7), PGM2(2), PHPT1(3), PMM1(1), RDH11(1), RDH12(1), TPI1(1), TSTA3(4) 7602014 74 30 74 23 19 34 11 6 4 0 0.99 1.00 603 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(3), B4GALT1(2), B4GALT2(5), FBP2(3), GAA(2), GALE(1), GALK1(1), GALK2(1), GALT(1), GANAB(2), GCK(2), GLB1(2), HK1(5), HK2(3), HK3(2), LALBA(1), LCT(10), MGAM(4), PFKM(1), PFKP(7), PGM1(2), PGM3(5) 6658645 65 27 64 32 20 26 7 6 6 0 0.99 1.00 604 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA3(1), PSMA4(3), PSMA6(2), PSMB2(1), PSMB3(1), PSMB4(1), PSMC3(5), RPN1(1), RPN2(2), UBE2A(1), UBE3A(3) 2599884 22 11 22 5 2 4 10 2 4 0 0.99 1.00 605 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(4), ALDOC(2), FBP2(3), G6PD(1), GPI(4), H6PD(1), PFKL(6), PFKM(1), PFKP(7), PGD(1), PGLS(1), PGM1(2), PGM3(5), PRPS1(1), PRPS1L1(1), PRPS2(3), TALDO1(2), TKTL1(4), TKTL2(3) 4967018 52 23 52 19 14 25 6 4 3 0 0.99 1.00 606 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP51A1(2), DHCR24(1), DHCR7(2), EBP(1), FDPS(3), GGCX(1), GGPS1(2), HMGCR(4), HSD17B7(1), MVD(1), MVK(3), NQO1(3), NSDHL(3), SC4MOL(2), SC5DL(1), SQLE(3), TM7SF2(1), VKORC1(1) 3948903 35 17 34 14 8 11 9 3 4 0 0.99 1.00 607 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 DUSP1(1), IKBKAP(2), IKBKB(3), LTA(1), MAP3K1(5), MAP3K14(1), NFKB1(4), RELA(2), TANK(1), TNFAIP3(4), TRAF2(2), TRAF3(2) 4550994 28 18 28 12 6 14 3 1 4 0 0.99 1.00 608 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASS(1), KARS(2) 945763 4 3 4 4 0 1 3 0 0 0 0.99 1.00 609 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(7), CALM1(1), CALM2(2), CALM3(1), CAPN2(3), CAPNS1(1), EP300(10), HDAC1(2), HDAC2(3), MEF2D(3), NFATC2(5), PPP3CA(2), PPP3CB(1) 4930709 41 19 41 12 12 12 9 1 7 0 0.99 1.00 610 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADM(1), ACSL1(2), ACSL3(3), ACSL4(1), CPT1A(2), CPT2(3), EHHADH(1), HADHA(2), SCP2(2), SLC25A20(2) 3383520 20 12 19 5 4 6 3 1 6 0 0.99 1.00 611 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(3), GUSB(1), UCHL1(1), UCHL3(3), UGDH(1), UGT1A5(1), UGT2B15(1), UGT2B4(2) 3283770 13 12 13 7 3 4 3 1 2 0 0.99 1.00 612 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT1(2), ACAT2(1), EHHADH(1), HADHA(2), HADHB(2), SDS(1) 1683381 10 6 9 4 2 2 1 1 4 0 1.00 1.00 613 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA3(1), PSMA4(3), PSMA6(2), PSMB10(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB8(2) 1749349 13 7 13 4 4 1 6 0 2 0 1.00 1.00 614 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(1), HADHA(2), SDS(1) 985397 4 2 3 3 2 0 0 0 2 0 1.00 1.00 615 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(4), ALDOC(2), FBP2(3), G6PD(1), GPI(4), H6PD(1), PFKM(1), PFKP(7), PGD(1), PGLS(1), PGM1(2), PGM3(5), PRPS1(1), PRPS1L1(1), PRPS2(3), TAL1(1), TALDO1(2) 4148536 40 18 40 17 12 18 6 1 3 0 1.00 1.00 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 100814 0 0 0 0 0 0 0 0 0 0 1.00 1.00