PLK1 signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations regulation of centriole-centriole cohesion -0.005 0.03 0.208 1.0 -9999.0 0.0 1.0 BUB1B -0.019 0.114 -9999.0 0.0 -0.325 6.0 6.0 PLK1 0.007 0.032 -9999.0 0.0 -0.109 3.0 3.0 PLK1S1 0.005 0.015 -9999.0 0.0 -0.047 3.0 3.0 KIF2A 0.009 0.043 -9999.0 0.0 -0.17 2.0 2.0 regulation of mitotic centrosome separation 0.007 0.032 -9999.0 0.0 -0.108 3.0 3.0 GOLGA2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Hec1/SPC24 -0.008 0.086 -9999.0 0.0 -0.244 6.0 6.0 WEE1 0.009 0.049 -9999.0 0.0 -0.205 1.0 1.0 cytokinesis -0.007 0.128 -9999.0 0.0 -0.424 4.0 4.0 PP2A-alpha B56 -0.018 0.233 -9999.0 0.0 -0.796 4.0 4.0 AURKA -0.002 0.065 -9999.0 0.0 -0.263 3.0 3.0 PICH/PLK1 -0.004 0.125 -9999.0 0.0 -0.43 3.0 3.0 CENPE -0.006 0.083 -9999.0 0.0 -0.253 5.0 5.0 RhoA/GTP 0.007 0.041 -9999.0 0.0 -0.288 1.0 1.0 positive regulation of microtubule depolymerization 0.009 0.043 -9999.0 0.0 -0.169 2.0 2.0 PPP2CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FZR1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TPX2 -0.018 0.092 -9999.0 0.0 -0.276 6.0 6.0 PAK1 0.017 0.001 -9999.0 0.0 -9999.0 0.0 0.0 SPC24 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FBXW11 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CLSPN -0.005 0.074 -9999.0 0.0 -0.302 3.0 3.0 GORASP1 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 metaphase 0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NLP 0.005 0.015 -9999.0 0.0 -0.047 3.0 3.0 G2 phase of mitotic cell cycle -0.001 0.003 -9999.0 0.0 -0.011 3.0 3.0 STAG2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRASP65/GM130/RAB1/GTP 0.009 0.085 -9999.0 0.0 -0.567 1.0 1.0 spindle elongation 0.007 0.032 -9999.0 0.0 -0.108 3.0 3.0 ODF2 0.017 0.003 -9999.0 0.0 -9999.0 0.0 0.0 BUB1 -0.042 0.255 -9999.0 0.0 -0.887 4.0 4.0 TPT1 0.006 0.038 -9999.0 0.0 -0.249 1.0 1.0 CDC25C -0.003 0.083 -9999.0 0.0 -0.414 2.0 2.0 CDC25B -0.002 0.082 -9999.0 0.0 -0.337 3.0 3.0 SGOL1 0.005 0.03 -9999.0 0.0 -0.208 1.0 1.0 RHOA 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 CCNB1/CDK1 0.004 0.108 -9999.0 0.0 -0.338 4.0 4.0 CDC14B 0.011 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC20 -0.014 0.112 -9999.0 0.0 -0.411 4.0 4.0 PLK1/PBIP1 0.001 0.068 -9999.0 0.0 -0.274 3.0 3.0 mitosis 0.001 0.008 0.035 3.0 -9999.0 0.0 3.0 FBXO5 0.008 0.034 -9999.0 0.0 -0.111 2.0 2.0 CDC2 0.009 0.06 -9999.0 0.0 -0.43 1.0 1.0 NDC80 -0.03 0.135 -9999.0 0.0 -0.411 6.0 6.0 metaphase plate congression 0.011 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ERCC6L -0.007 0.136 -9999.0 0.0 -0.405 4.0 4.0 NLP/gamma Tubulin 0.009 0.016 -9999.0 0.0 -9999.0 0.0 0.0 microtubule cytoskeleton organization 0.006 0.038 -9999.0 0.0 -0.248 1.0 1.0 G2/M transition DNA damage checkpoint -0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 PPP1R12A 0.009 0.058 -9999.0 0.0 -0.414 1.0 1.0 interphase -0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 PLK1/PRC1-2 0.005 0.102 -9999.0 0.0 -0.325 4.0 4.0 GRASP65/GM130/RAB1/GTP/PLK1 0.025 0.048 -9999.0 0.0 -0.174 2.0 2.0 RAB1A 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 prophase 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Aurora A/BORA 0.003 0.05 -9999.0 0.0 -0.163 4.0 4.0 mitotic prometaphase -0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 proteasomal ubiquitin-dependent protein catabolic process 0.023 0.043 -9999.0 0.0 -9999.0 0.0 0.0 microtubule-based process 0.004 0.073 -9999.0 0.0 -0.281 3.0 3.0 Golgi organization 0.007 0.032 -9999.0 0.0 -0.108 3.0 3.0 Cohesin/SA2 0.014 0.028 -9999.0 0.0 -9999.0 0.0 0.0 PPP1CB/MYPT1 0.013 0.058 -9999.0 0.0 -0.284 2.0 2.0 KIF20A -0.006 0.098 -9999.0 0.0 -0.411 3.0 3.0 APC/C/CDC20 0.0 0.078 -9999.0 0.0 -0.26 4.0 4.0 PPP2R1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 chromosome segregation 0.001 0.067 -9999.0 0.0 -0.27 3.0 3.0 PRC1 -0.004 0.09 -9999.0 0.0 -0.374 3.0 3.0 ECT2 0.006 0.045 -9999.0 0.0 -0.146 3.0 3.0 C13orf34 0.004 0.049 -9999.0 0.0 -0.156 4.0 4.0 NUDC 0.011 0.019 -9999.0 0.0 -9999.0 0.0 0.0 regulation of attachment of spindle microtubules to kinetochore -0.018 0.113 -9999.0 0.0 -0.321 6.0 6.0 spindle assembly 0.009 0.023 -9999.0 0.0 -0.078 2.0 2.0 spindle stabilization 0.005 0.015 -9999.0 0.0 -0.047 3.0 3.0 APC/C/HCDH1 0.021 0.001 -9999.0 0.0 -9999.0 0.0 0.0 MKLP2/PLK1 0.004 0.073 -9999.0 0.0 -0.283 3.0 3.0 CCNB1 -0.006 0.101 -9999.0 0.0 -0.423 3.0 3.0 PPP1CB 0.009 0.058 -9999.0 0.0 -0.413 1.0 1.0 BTRC 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK2 0.008 0.063 -9999.0 0.0 -0.275 2.0 2.0 TUBG1 0.011 0.015 -9999.0 0.0 -9999.0 0.0 0.0 G2/M transition of mitotic cell cycle -0.029 0.095 -9999.0 0.0 -0.331 4.0 4.0 MLF1IP -0.005 0.07 -9999.0 0.0 -0.294 3.0 3.0 INCENP 0.009 0.059 -9999.0 0.0 -0.421 1.0 1.0