p75(NTR)-mediated signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Sortilin/TRAF6 0.015 0.058 -9999.0 0.0 -0.28 2.0 2.0 Necdin/E2F1 -0.021 0.122 -9999.0 0.0 -0.29 8.0 8.0 proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E 0.031 0.043 -9999.0 0.0 -0.185 1.0 1.0 NGF (dimer)/p75(NTR)/BEX1 -0.074 0.123 -9999.0 0.0 -0.217 22.0 22.0 NT-4/5 (dimer)/p75(NTR) 0.005 0.041 -9999.0 0.0 -0.203 2.0 2.0 IKBKB 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.005 0.083 -9999.0 0.0 -0.233 4.0 4.0 IKBKG 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BDNF -0.065 0.157 -9999.0 0.0 -0.355 12.0 12.0 MGDIs/NGR/p75(NTR)/LINGO1 0.003 0.074 -9999.0 0.0 -0.227 1.0 1.0 FURIN 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 proBDNF (dimer)/p75(NTR)/Sortilin -0.02 0.108 -9999.0 0.0 -0.216 12.0 12.0 LINGO1 -0.0 0.073 -9999.0 0.0 -0.3 3.0 3.0 Sortilin/TRAF6/NRIF -0.012 0.039 -9999.0 0.0 -9999.0 0.0 0.0 proBDNF (dimer) -0.065 0.157 -9999.0 0.0 -0.355 12.0 12.0 NTRK1 -0.004 0.09 -9999.0 0.0 -0.374 3.0 3.0 RTN4R -0.008 0.091 -9999.0 0.0 -0.327 4.0 4.0 neuron apoptosis -0.012 0.104 -9999.0 0.0 -0.349 1.0 1.0 IRAK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.013 0.034 -9999.0 0.0 -0.159 2.0 2.0 ARHGDIA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.007 0.041 -9999.0 0.0 -0.288 1.0 1.0 Gamma Secretase 0.041 0.048 -9999.0 0.0 -9999.0 0.0 0.0 proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 -0.024 0.091 -9999.0 0.0 -0.161 16.0 16.0 MAGEH1 -0.077 0.162 -9999.0 0.0 -0.347 14.0 14.0 proNGF (dimer)/p75(NTR)/Sortilin/Necdin 0.005 0.07 -9999.0 0.0 -0.204 3.0 3.0 Mammalian IAPs/DIABLO -0.008 0.085 -9999.0 0.0 -0.204 6.0 6.0 proNGF (dimer) -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAGED1 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 APP 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NT-4/5 (dimer) 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZNF274 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP/RHOGDI 0.02 0.041 -9999.0 0.0 -0.191 1.0 1.0 NGF -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell cycle arrest 0.05 0.059 -9999.0 0.0 -9999.0 0.0 0.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK 0.019 0.048 -9999.0 0.0 -0.19 2.0 2.0 NT-4/5 (dimer)/p75(NTR)/TRAF6 0.007 0.059 -9999.0 0.0 -0.197 4.0 4.0 NCSTN 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.017 0.034 -9999.0 0.0 -0.159 2.0 2.0 PSENEN 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 mol:ceramide 0.02 0.03 -9999.0 0.0 -0.134 2.0 2.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs 0.017 0.049 -9999.0 0.0 -9999.0 0.0 0.0 p75(NTR)/beta APP 0.018 0.042 -9999.0 0.0 -0.194 2.0 2.0 BEX1 -0.137 0.196 -9999.0 0.0 -0.379 21.0 21.0 mol:GDP 0.002 0.033 -9999.0 0.0 -0.167 2.0 2.0 NGF (dimer) -0.067 0.107 -9999.0 0.0 -0.175 26.0 26.0 MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI 0.015 0.068 -9999.0 0.0 -0.197 1.0 1.0 PIK3R1 -0.038 0.134 -9999.0 0.0 -0.355 8.0 8.0 RAC1/GTP 0.015 0.029 -9999.0 0.0 -0.132 2.0 2.0 MYD88 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CHUK 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 NGF (dimer)/p75(NTR)/PKA 0.017 0.035 -9999.0 0.0 -0.159 2.0 2.0 RHOB 0.006 0.06 -9999.0 0.0 -0.3 2.0 2.0 RHOA 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 MAGE-G1/E2F1 0.002 0.075 -9999.0 0.0 -0.228 5.0 5.0 NT3 (dimer) -0.0 0.073 -9999.0 0.0 -0.299 3.0 3.0 TP53 -0.013 0.092 -9999.0 0.0 -0.236 2.0 2.0 PRDM4 0.02 0.03 -9999.0 0.0 -9999.0 0.0 0.0 BDNF (dimer) -0.162 0.172 -9999.0 0.0 -0.305 26.0 26.0 PIK3CA 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 SORT1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 activation of caspase activity 0.028 0.041 -9999.0 0.0 -0.183 1.0 1.0 proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 0.019 0.054 -9999.0 0.0 -0.204 2.0 2.0 RHOC 0.012 0.043 -9999.0 0.0 -0.3 1.0 1.0 XIAP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK10 0.003 0.083 -9999.0 0.0 -0.34 1.0 1.0 DIABLO 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMPD2 0.02 0.03 -9999.0 0.0 -0.135 2.0 2.0 APH1B 0.004 0.071 -9999.0 0.0 -0.355 2.0 2.0 APH1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 proNGF (dimer)/p75(NTR)/Sortilin 0.017 0.035 -9999.0 0.0 -0.159 2.0 2.0 PSEN1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 APAF-1/Pro-Caspase 9 0.02 0.041 -9999.0 0.0 -0.28 1.0 1.0 NT3 (dimer)/p75(NTR) 0.006 0.064 -9999.0 0.0 -0.194 5.0 5.0 MAPK8 0.005 0.084 -9999.0 0.0 -0.287 1.0 1.0 MAPK9 0.005 0.087 -9999.0 0.0 -0.262 2.0 2.0 APAF1 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 NTF3 -0.0 0.073 -9999.0 0.0 -0.3 3.0 3.0 NTF4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NDN -0.024 0.119 -9999.0 0.0 -0.355 6.0 6.0 RAC1/GDP 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA-B-C/GDP 0.021 0.049 -9999.0 0.0 -9999.0 0.0 0.0 p75 CTF/Sortilin/TRAF6/NRIF 0.033 0.051 -9999.0 0.0 -0.197 2.0 2.0 RhoA-B-C/GTP 0.016 0.034 -9999.0 0.0 -0.158 2.0 2.0 proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF -0.006 0.1 -9999.0 0.0 -0.194 10.0 10.0 proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 -0.016 0.105 -9999.0 0.0 -0.213 10.0 10.0 PRKACB 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 proBDNF (dimer)/p75 ECD -0.037 0.113 -9999.0 0.0 -0.234 13.0 13.0 ChemicalAbstracts:86-01-1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BIRC3 -0.059 0.154 -9999.0 0.0 -0.36 11.0 11.0 BIRC2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 neuron projection morphogenesis 0.014 0.098 0.15 12.0 -0.264 1.0 13.0 BAD 0.007 0.083 -9999.0 0.0 -0.242 2.0 2.0 RIPK2 0.012 0.043 -9999.0 0.0 -0.3 1.0 1.0 NGFR 0.006 0.06 -9999.0 0.0 -0.3 2.0 2.0 CYCS 0.022 0.04 -9999.0 0.0 -0.184 1.0 1.0 ADAM17 0.012 0.043 -9999.0 0.0 -0.3 1.0 1.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2 0.016 0.058 -9999.0 0.0 -0.204 2.0 2.0 BCL2L11 0.008 0.083 -9999.0 0.0 -0.242 2.0 2.0 BDNF (dimer)/p75(NTR) -0.039 0.126 -9999.0 0.0 -0.268 12.0 12.0 PI3K -0.007 0.092 -9999.0 0.0 -0.257 4.0 4.0 proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 0.025 0.048 -9999.0 0.0 -0.284 1.0 1.0 NDNL2 0.012 0.043 -9999.0 0.0 -0.3 1.0 1.0 YWHAE 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 PRKCI 0.012 0.043 -9999.0 0.0 -0.3 1.0 1.0 NGF (dimer)/p75(NTR) 0.005 0.041 -9999.0 0.0 -0.203 2.0 2.0 ChemicalAbstracts:146-91-8 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 proNGF (dimer)/p75(NTR)/Sortilin/NRAGE 0.023 0.045 -9999.0 0.0 -0.204 1.0 1.0 TRAF6 0.002 0.081 -9999.0 0.0 -0.411 2.0 2.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCZ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLG 0.006 0.06 -9999.0 0.0 -0.3 2.0 2.0 oligodendrocyte cell fate commitment 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP6 -0.013 0.087 -9999.0 0.0 -0.202 8.0 8.0 SQSTM1 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 NGFRAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP3 0.01 0.079 -9999.0 0.0 -0.225 2.0 2.0 E2F1 -0.01 0.099 -9999.0 0.0 -0.355 4.0 4.0 CASP9 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IKK complex -0.016 0.039 -9999.0 0.0 -9999.0 0.0 0.0 NGF (dimer)/TRKA -0.002 0.063 -9999.0 0.0 -0.26 3.0 3.0 MMP7 -0.154 0.195 -9999.0 0.0 -0.369 24.0 24.0 proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.027 0.052 -9999.0 0.0 -0.185 2.0 2.0 MMP3 -0.105 0.176 -9999.0 0.0 -0.349 18.0 18.0 APAF-1/Caspase 9 -0.028 0.053 -9999.0 0.0 -0.238 1.0 1.0