Presenilin action in Notch and Wnt signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Delta 1/NOTCH/NOTCH(cleaved) 0.022 0.078 -9999.0 0.0 -0.511 1.0 1.0 HDAC1 0.016 0.009 -9999.0 0.0 -9999.0 0.0 0.0 AES 0.009 0.057 -9999.0 0.0 -0.408 1.0 1.0 FBXW11 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DTX1 0.012 0.043 -9999.0 0.0 -0.3 1.0 1.0 LRP6/FZD1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TLE1 0.011 0.043 -9999.0 0.0 -0.301 1.0 1.0 AP1 -0.078 0.134 -9999.0 0.0 -0.285 12.0 12.0 NCSTN 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADAM10 0.004 0.071 -9999.0 0.0 -0.355 2.0 2.0 Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 -0.007 0.102 -9999.0 0.0 -0.436 1.0 1.0 NICD/RBPSUH 0.022 0.077 -9999.0 0.0 -0.5 1.0 1.0 WIF1 -0.168 0.189 -9999.0 0.0 -0.353 27.0 27.0 NOTCH1 0.013 0.08 -9999.0 0.0 -0.533 1.0 1.0 PSENEN 0.01 0.058 -9999.0 0.0 -0.412 1.0 1.0 KREMEN2 -0.071 0.16 -9999.0 0.0 -0.351 13.0 13.0 DKK1 -0.152 0.179 -9999.0 0.0 -0.334 26.0 26.0 beta catenin/beta TrCP1 0.032 0.073 -9999.0 0.0 -0.255 2.0 2.0 APH1B 0.004 0.071 -9999.0 0.0 -0.355 2.0 2.0 APH1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AXIN1 -0.015 0.06 -9999.0 0.0 -0.393 1.0 1.0 CtBP/CBP/TCF1/TLE1/AES -0.005 0.087 -9999.0 0.0 -9999.0 0.0 0.0 PSEN1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FOS -0.079 0.166 -9999.0 0.0 -0.355 14.0 14.0 JUN -0.026 0.124 -9999.0 0.0 -0.374 6.0 6.0 MAP3K7 0.017 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.076 -9999.0 0.0 -0.274 2.0 2.0 MAPK3 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DKK2/LRP6/Kremen 2 -0.026 0.108 -9999.0 0.0 -0.249 7.0 7.0 HNF1A -0.052 0.156 -9999.0 0.0 -0.398 9.0 9.0 CTBP1 0.017 0.002 -9999.0 0.0 -9999.0 0.0 0.0 MYC 0.016 0.044 -9999.0 0.0 -9999.0 0.0 0.0 NKD1 -0.077 0.154 -9999.0 0.0 -0.322 15.0 15.0 FZD1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NOTCH1 precursor/Deltex homolog 1 0.02 0.079 -9999.0 0.0 -0.5 1.0 1.0 apoptosis -0.078 0.133 -9999.0 0.0 -0.283 12.0 12.0 Delta 1/NOTCHprecursor 0.022 0.077 -9999.0 0.0 -0.5 1.0 1.0 DLL1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PPARD 0.021 0.022 -9999.0 0.0 -9999.0 0.0 0.0 Gamma Secretase 0.041 0.049 -9999.0 0.0 -9999.0 0.0 0.0 APC -0.008 0.029 -9999.0 0.0 -9999.0 0.0 0.0 DVL1 0.012 0.026 -9999.0 0.0 -9999.0 0.0 0.0 CSNK2A1 0.018 0.001 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP1 0.017 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DKK1/LRP6/Kremen 2 -0.115 0.142 -9999.0 0.0 -0.295 15.0 15.0 LRP6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CSNK1A1 0.018 0.001 -9999.0 0.0 -9999.0 0.0 0.0 NLK 0.024 0.021 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 -0.061 0.301 -9999.0 0.0 -1.267 3.0 3.0 WNT1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Axin1/APC/beta catenin 0.023 0.067 -9999.0 0.0 -0.292 1.0 1.0 DKK2 0.004 0.071 -9999.0 0.0 -0.355 2.0 2.0 NOTCH1 precursor/DVL1 0.022 0.071 -9999.0 0.0 -0.438 1.0 1.0 GSK3B 0.017 0.001 -9999.0 0.0 -9999.0 0.0 0.0 FRAT1 0.017 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NOTCH/Deltex homolog 1 0.019 0.08 -9999.0 0.0 -0.511 1.0 1.0 PPP2R5D 0.052 0.073 0.219 3.0 -9999.0 0.0 3.0 MAPK1 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 WNT1/LRP6/FZD1 -0.058 0.107 -9999.0 0.0 -0.197 13.0 13.0 RBPJ 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CREBBP 0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0