BCR signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations JUN -0.022 0.103 -9999.0 0.0 -0.251 6.0 6.0 IKBKB 0.006 0.081 -9999.0 0.0 -0.267 2.0 2.0 AKT1 0.009 0.081 0.19 4.0 -0.198 1.0 5.0 IKBKG 0.005 0.083 -9999.0 0.0 -0.277 2.0 2.0 CALM1 -0.006 0.087 -9999.0 0.0 -0.313 2.0 2.0 PIK3CA 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 MAP3K1 -0.017 0.12 -9999.0 0.0 -0.372 4.0 4.0 MAP3K7 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.015 0.09 -9999.0 0.0 -0.301 3.0 3.0 DOK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AP-1 -0.023 0.079 -9999.0 0.0 -0.17 3.0 3.0 LYN 0.012 0.043 -9999.0 0.0 -0.3 1.0 1.0 BLNK -0.006 0.098 -9999.0 0.0 -0.411 3.0 3.0 SHC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BCR complex 0.012 0.058 -9999.0 0.0 -0.222 3.0 3.0 CD22 -0.016 0.096 -9999.0 0.0 -0.326 2.0 2.0 CAMK2G 0.0 0.082 -9999.0 0.0 -0.289 2.0 2.0 CSNK2A1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 INPP5D 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC/GRB2/SOS1 -0.025 0.05 -9999.0 0.0 -9999.0 0.0 0.0 GO:0007205 -0.015 0.091 -9999.0 0.0 -0.305 3.0 3.0 SYK -0.012 0.106 -9999.0 0.0 -0.383 4.0 4.0 ELK1 -0.007 0.088 -9999.0 0.0 -0.285 3.0 3.0 NFATC1 0.002 0.113 -9999.0 0.0 -0.47 2.0 2.0 B-cell antigen/BCR complex 0.012 0.058 -9999.0 0.0 -0.222 3.0 3.0 PAG1/CSK 0.002 0.075 -9999.0 0.0 -0.228 5.0 5.0 NFKBIB 0.014 0.031 -9999.0 0.0 -9999.0 0.0 0.0 HRAS 0.0 0.079 -9999.0 0.0 -0.27 2.0 2.0 NFKBIA 0.014 0.03 -9999.0 0.0 -9999.0 0.0 0.0 NF-kappa-B/RelA/I kappa B beta 0.019 0.026 -9999.0 0.0 -9999.0 0.0 0.0 RasGAP/Csk 0.002 0.09 -9999.0 0.0 -0.254 1.0 1.0 mol:GDP -0.013 0.089 -9999.0 0.0 -0.294 3.0 3.0 PTEN -0.022 0.124 -9999.0 0.0 -0.411 5.0 5.0 CD79B 0.004 0.071 -9999.0 0.0 -0.355 2.0 2.0 NF-kappa-B/RelA/I kappa B alpha 0.019 0.026 -9999.0 0.0 -9999.0 0.0 0.0 GRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K/BCAP/CD19 -0.024 0.132 -9999.0 0.0 -0.371 4.0 4.0 PIK3R1 -0.038 0.134 -9999.0 0.0 -0.355 8.0 8.0 mol:IP3 -0.015 0.092 -9999.0 0.0 -0.307 3.0 3.0 CSK 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FOS -0.041 0.116 -9999.0 0.0 -0.327 4.0 4.0 CHUK -0.001 0.092 -9999.0 0.0 -0.259 4.0 4.0 IBTK 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 CARD11/BCL10/MALT1/TAK1 -0.015 0.106 -9999.0 0.0 -0.366 3.0 3.0 PTPN6 -0.013 0.094 -9999.0 0.0 -0.39 1.0 1.0 RELA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BCL2A1 0.015 0.027 -9999.0 0.0 -0.092 1.0 1.0 VAV2 -0.005 0.09 -9999.0 0.0 -0.413 1.0 1.0 ubiquitin-dependent protein catabolic process 0.018 0.03 -9999.0 0.0 -9999.0 0.0 0.0 BTK -0.017 0.14 -9999.0 0.0 -1.028 1.0 1.0 CD19 -0.012 0.093 -9999.0 0.0 -0.415 1.0 1.0 MAP4K1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CD72 -0.024 0.119 -9999.0 0.0 -0.355 6.0 6.0 PAG1 -0.016 0.106 -9999.0 0.0 -0.344 5.0 5.0 MAPK14 -0.007 0.107 -9999.0 0.0 -0.32 4.0 4.0 SH3BP5 -0.024 0.119 -9999.0 0.0 -0.355 6.0 6.0 PIK3AP1 -0.011 0.093 -9999.0 0.0 -0.311 3.0 3.0 B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 -0.034 0.116 -9999.0 0.0 -0.337 4.0 4.0 RAF1 0.004 0.077 -9999.0 0.0 -0.251 2.0 2.0 RasGAP/p62DOK/SHIP -0.003 0.084 -9999.0 0.0 -0.243 1.0 1.0 CD79A 0.012 0.043 -9999.0 0.0 -0.3 1.0 1.0 re-entry into mitotic cell cycle -0.023 0.079 -9999.0 0.0 -0.176 2.0 2.0 RASA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 0.016 0.069 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.013 0.071 -9999.0 0.0 -0.212 1.0 1.0 CD72/SHP1 -0.021 0.103 -9999.0 0.0 -0.364 1.0 1.0 NFKB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 -0.014 0.112 -9999.0 0.0 -0.307 5.0 5.0 actin cytoskeleton organization 0.002 0.082 -9999.0 0.0 -0.36 1.0 1.0 NF-kappa-B/RelA 0.04 0.056 -9999.0 0.0 -9999.0 0.0 0.0 Calcineurin -0.008 0.087 -9999.0 0.0 -0.259 3.0 3.0 PI3K -0.051 0.091 -9999.0 0.0 -0.352 2.0 2.0 B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 -0.016 0.097 -9999.0 0.0 -0.332 3.0 3.0 SOS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Bam32/HPK1 -0.05 0.188 -9999.0 0.0 -0.659 4.0 4.0 DAPP1 -0.065 0.207 -9999.0 0.0 -0.74 4.0 4.0 cytokine secretion 0.003 0.107 -9999.0 0.0 -0.436 2.0 2.0 mol:DAG -0.015 0.092 -9999.0 0.0 -0.307 3.0 3.0 PLCG2 -0.042 0.143 -9999.0 0.0 -0.383 8.0 8.0 MAP2K1 0.01 0.073 -9999.0 0.0 -0.23 2.0 2.0 B-cell antigen/BCR complex/FcgammaRIIB -0.021 0.103 -9999.0 0.0 -0.239 7.0 7.0 mol:PI-3-4-5-P3 -0.023 0.095 0.233 4.0 -0.273 1.0 5.0 ETS1 0.004 0.086 -9999.0 0.0 -0.322 2.0 2.0 B-cell antigen/BCR complex/LYN/SYK/BLNK 0.01 0.084 -9999.0 0.0 -9999.0 0.0 0.0 B-cell antigen/BCR complex/LYN -0.015 0.094 -9999.0 0.0 -0.299 3.0 3.0 MALT1 -0.008 0.091 -9999.0 0.0 -0.327 4.0 4.0 TRAF6 0.002 0.081 -9999.0 0.0 -0.41 2.0 2.0 RAC1 0.001 0.085 -9999.0 0.0 -0.38 1.0 1.0 B-cell antigen/BCR complex/LYN/SYK -0.007 0.1 -9999.0 0.0 -0.307 2.0 2.0 CARD11 -0.017 0.093 -9999.0 0.0 -0.317 2.0 2.0 FCGR2B -0.057 0.15 -9999.0 0.0 -0.35 11.0 11.0 PPP3CA 0.002 0.081 -9999.0 0.0 -0.411 2.0 2.0 BCL10 0.012 0.043 -9999.0 0.0 -0.299 1.0 1.0 IKK complex 0.013 0.041 -9999.0 0.0 -0.112 2.0 2.0 PTPRC -0.044 0.138 -9999.0 0.0 -0.349 9.0 9.0 PDPK1 0.006 0.076 0.179 4.0 -0.186 1.0 5.0 PPP3CB 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PPP3CC -0.012 0.106 -9999.0 0.0 -0.383 4.0 4.0 POU2F2 0.017 0.023 -9999.0 0.0 -9999.0 0.0 0.0