Integrins in angiogenesis Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR2 homodimer/VEGFA homodimer 0.009 0.07 -9999.0 0.0 -0.28 3.0 3.0 alphaV beta3 Integrin -0.01 0.093 -9999.0 0.0 -0.248 4.0 4.0 PTK2 0.005 0.124 -9999.0 0.0 -0.413 2.0 2.0 IGF1R -0.042 0.143 -9999.0 0.0 -0.383 8.0 8.0 PI4KB 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MFGE8 -0.008 0.091 -9999.0 0.0 -0.327 4.0 4.0 SRC 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDKN1B -0.041 0.154 -9999.0 0.0 -0.449 6.0 6.0 VEGFA -0.006 0.098 -9999.0 0.0 -0.411 3.0 3.0 ILK 0.013 0.039 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.019 0.036 -9999.0 0.0 -9999.0 0.0 0.0 PTK2B -0.005 0.092 -9999.0 0.0 -0.315 2.0 2.0 alphaV/beta3 Integrin/JAM-A 0.01 0.08 -9999.0 0.0 -0.255 1.0 1.0 CBL 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV beta3 Integrin/ANGPTL3 -0.008 0.093 -9999.0 0.0 -0.244 5.0 5.0 IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.073 0.159 -9999.0 0.0 -0.286 15.0 15.0 VEGF/Rho/ROCK/alphaV/beta3 Integrin -0.001 0.104 -9999.0 0.0 -0.421 2.0 2.0 alphaV/beta3 Integrin/Syndecan-1 -0.013 0.098 -9999.0 0.0 -0.241 6.0 6.0 PI4KA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/IRS1 -0.114 0.148 -9999.0 0.0 -0.384 10.0 10.0 PI4 Kinase 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 alphaV/beta3 Integrin/Osteopontin -0.074 0.156 -9999.0 0.0 -0.306 14.0 14.0 RPS6KB1 -0.085 0.16 -9999.0 0.0 -0.37 10.0 10.0 TLN1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 -0.032 0.112 -9999.0 0.0 -0.32 4.0 4.0 GPR124 0.002 0.081 -9999.0 0.0 -0.411 2.0 2.0 MAPK1 -0.036 0.112 -9999.0 0.0 -0.32 4.0 4.0 PXN 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 -0.038 0.134 -9999.0 0.0 -0.355 8.0 8.0 alphaV/beta3 Integrin/Tumstatin -0.01 0.104 -9999.0 0.0 -0.274 5.0 5.0 cell adhesion -0.019 0.11 -9999.0 0.0 -0.266 6.0 6.0 ANGPTL3 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 VEGFR2 homodimer/VEGFA homodimer/Src 0.021 0.06 -9999.0 0.0 -0.227 3.0 3.0 IGF-1R heterotetramer -0.042 0.143 -9999.0 0.0 -0.382 8.0 8.0 Rac1/GDP 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TGFBR2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ITGB3 -0.026 0.113 -9999.0 0.0 -0.315 7.0 7.0 IGF1 -0.103 0.18 -9999.0 0.0 -0.365 17.0 17.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-matrix adhesion -0.013 0.097 -9999.0 0.0 -0.24 6.0 6.0 apoptosis -0.004 0.09 -9999.0 0.0 -0.373 3.0 3.0 CD47 -0.004 0.09 -9999.0 0.0 -0.374 3.0 3.0 alphaV/beta3 Integrin/CD47 -0.015 0.111 -9999.0 0.0 -0.274 7.0 7.0 VCL 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 alphaV/beta3 Integrin/Del1 -0.026 0.106 -9999.0 0.0 -0.238 8.0 8.0 CSF1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3C2A 0.006 0.065 -9999.0 0.0 -0.371 1.0 1.0 PI4 Kinase/Pyk2 -0.029 0.062 -9999.0 0.0 -0.313 1.0 1.0 VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.003 0.103 -9999.0 0.0 -0.246 6.0 6.0 FAK1/Vinculin 0.014 0.105 -9999.0 0.0 -0.328 2.0 2.0 alphaV beta3/Integrin/ppsTEM5 -0.013 0.098 -9999.0 0.0 -0.241 6.0 6.0 RHOA 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 VTN 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BCAR1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FGF2 0.006 0.06 -9999.0 0.0 -0.3 2.0 2.0 F11R 0.015 0.041 -9999.0 0.0 -0.194 2.0 2.0 alphaV/beta3 Integrin/Lactadherin -0.018 0.103 -9999.0 0.0 -0.256 6.0 6.0 alphaV/beta3 Integrin/TGFBR2 -0.003 0.089 -9999.0 0.0 -0.248 4.0 4.0 alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.033 0.051 -9999.0 0.0 -0.197 2.0 2.0 HSP90AA1 0.002 0.081 -9999.0 0.0 -0.411 2.0 2.0 alphaV/beta3 Integrin/Talin -0.001 0.08 -9999.0 0.0 -0.224 4.0 4.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FN1 -0.0 0.073 -9999.0 0.0 -0.3 3.0 3.0 alphaV/beta3 Integrin/Pyk2 0.001 0.095 -9999.0 0.0 -0.317 2.0 2.0 SDC1 0.002 0.081 -9999.0 0.0 -0.411 2.0 2.0 VAV3 -0.005 0.085 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IRS1 -0.02 0.118 -9999.0 0.0 -0.389 5.0 5.0 FAK1/Paxillin 0.015 0.105 -9999.0 0.0 -0.328 2.0 2.0 cell migration 0.02 0.098 -9999.0 0.0 -0.295 2.0 2.0 ITGAV -0.004 0.09 -9999.0 0.0 -0.374 3.0 3.0 PI3K -0.01 0.112 -9999.0 0.0 -0.295 5.0 5.0 SPP1 -0.107 0.179 -9999.0 0.0 -0.355 18.0 18.0 KDR 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Caspase 8 -0.004 0.09 -9999.0 0.0 -0.373 3.0 3.0 COL4A3 0.004 0.071 -9999.0 0.0 -0.355 2.0 2.0 angiogenesis -0.025 0.112 -9999.0 0.0 -0.333 4.0 4.0 Rac1/GTP 0.004 0.08 -9999.0 0.0 -9999.0 0.0 0.0 EDIL3 -0.02 0.118 -9999.0 0.0 -0.389 5.0 5.0 cell proliferation -0.003 0.088 -9999.0 0.0 -0.248 4.0 4.0