Signaling events mediated by VEGFR1 and VEGFR2 Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations alphaV beta3 Integrin -0.019 0.103 -9999.0 0.0 -0.243 9.0 9.0 AKT1 -0.012 0.171 -9999.0 0.0 -0.46 4.0 4.0 PTK2B -0.006 0.117 -9999.0 0.0 -0.305 3.0 3.0 VEGFR2 homodimer/Frs2 0.025 0.057 -9999.0 0.0 -0.275 1.0 1.0 CAV1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CALM1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR2 homodimer/VEGFA homodimer/Frs2 0.017 0.096 -9999.0 0.0 -0.285 2.0 2.0 endothelial cell proliferation 0.007 0.147 -9999.0 0.0 -0.389 4.0 4.0 mol:Ca2+ 0.005 0.132 -9999.0 0.0 -0.375 4.0 4.0 VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Rac 0.027 0.092 -9999.0 0.0 -0.262 2.0 2.0 RP11-342D11.1 -0.001 0.129 -9999.0 0.0 -0.381 4.0 4.0 CDH5 -0.006 0.098 -9999.0 0.0 -0.411 3.0 3.0 VEGFA homodimer 0.03 0.058 -9999.0 0.0 -0.204 3.0 3.0 SHC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC2 -0.035 0.118 -9999.0 0.0 -0.3 9.0 9.0 HRAS/GDP -0.037 0.089 -9999.0 0.0 -0.316 4.0 4.0 SH2D2A -0.0 0.073 -9999.0 0.0 -0.3 3.0 3.0 VEGFR2 homodimer/VEGFA homodimer/SHP1/eNOS 0.021 0.125 -9999.0 0.0 -0.344 3.0 3.0 VEGFR2 homodimer/VEGFA homodimer/TsAd 0.007 0.099 -9999.0 0.0 -0.285 2.0 2.0 VEGFR1 homodimer -0.014 0.112 -9999.0 0.0 -0.41 4.0 4.0 SHC/GRB2/SOS1 0.024 0.126 -9999.0 0.0 -0.346 4.0 4.0 GRB10 -0.01 0.184 -9999.0 0.0 -0.493 6.0 6.0 PTPN11 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PAK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Cadherin/beta catenin 0.015 0.128 -9999.0 0.0 -0.355 4.0 4.0 HRAS 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VEGF/Rho/ROCK1/Integrin Complex -0.006 0.115 -9999.0 0.0 -0.363 3.0 3.0 HIF1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FRS2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 oxygen and reactive oxygen species metabolic process 0.025 0.09 -9999.0 0.0 -0.259 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FLT4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nck/Pak 0.02 0.041 -9999.0 0.0 -0.28 1.0 1.0 VEGFR2 homodimer/VEGFA homodimer/Fyn 0.004 0.105 -9999.0 0.0 -0.285 2.0 2.0 mol:GDP -0.04 0.096 -9999.0 0.0 -0.338 4.0 4.0 mol:NADP 0.02 0.114 -9999.0 0.0 -0.311 3.0 3.0 eNOS/Hsp90 0.023 0.117 -9999.0 0.0 -0.316 3.0 3.0 PIK3R1 -0.038 0.134 -9999.0 0.0 -0.355 8.0 8.0 mol:IP3 0.005 0.133 -9999.0 0.0 -0.379 4.0 4.0 HIF1A/ARNT 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHB 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VEGFA -0.011 0.103 -9999.0 0.0 -0.421 3.0 3.0 VEGFC -0.024 0.119 -9999.0 0.0 -0.355 6.0 6.0 FAK1/Vinculin 0.008 0.124 -9999.0 0.0 -0.368 2.0 2.0 mol:Ca ++ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.005 0.127 -9999.0 0.0 -0.301 5.0 5.0 PTPN6 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 EPAS1 0.009 0.078 -9999.0 0.0 -0.36 2.0 2.0 mol:L-citrulline 0.02 0.114 -9999.0 0.0 -0.311 3.0 3.0 ITGAV -0.004 0.09 -9999.0 0.0 -0.374 3.0 3.0 PIK3CA 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 VEGFR2 homodimer/VEGFA homodimer/Frs2/GRB2 0.027 0.092 -9999.0 0.0 -0.262 2.0 2.0 VEGFR2 homodimer/VEGFA homodimer 0.009 0.145 -9999.0 0.0 -0.414 4.0 4.0 VEGFR2/3 heterodimer 0.025 0.057 -9999.0 0.0 -0.275 1.0 1.0 VEGFB 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK11 0.009 0.14 -9999.0 0.0 -0.403 4.0 4.0 VEGFR2 homodimer 0.018 0.069 -9999.0 0.0 -0.335 1.0 1.0 FLT1 -0.014 0.112 -9999.0 0.0 -0.411 4.0 4.0 NEDD4 0.013 0.026 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 0.005 0.121 -9999.0 0.0 -0.339 4.0 4.0 MAPK1 0.003 0.124 -9999.0 0.0 -0.339 4.0 4.0 VEGFA145/NRP2 -0.007 0.093 -9999.0 0.0 -0.263 6.0 6.0 VEGFR1/2 heterodimer 0.006 0.092 -9999.0 0.0 -0.287 3.0 3.0 KDR 0.018 0.069 -9999.0 0.0 -0.336 1.0 1.0 VEGFA165/NRP1/VEGFR2 homodimer 0.007 0.145 -9999.0 0.0 -0.415 4.0 4.0 SRC 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 platelet activating factor biosynthetic process 0.005 0.125 -9999.0 0.0 -0.348 4.0 4.0 PI3K -0.017 0.178 -9999.0 0.0 -0.559 3.0 3.0 VEGFR2 homodimer/VEGFA homodimer/NCK1 0.012 0.099 -9999.0 0.0 -0.285 2.0 2.0 FES -0.008 0.138 -9999.0 0.0 -0.383 4.0 4.0 GAB1 -0.009 0.163 -9999.0 0.0 -0.604 2.0 2.0 VEGFR2 homodimer/VEGFA homodimer/Src 0.017 0.096 -9999.0 0.0 -0.285 2.0 2.0 CTNNB1 0.002 0.081 -9999.0 0.0 -0.411 2.0 2.0 SOS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARNT 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 eNOS/Caveolin-1 0.027 0.11 -9999.0 0.0 -0.307 2.0 2.0 VEGFR2 homodimer/VEGFA homodimer/Yes 0.017 0.096 -9999.0 0.0 -0.285 2.0 2.0 PI3K/GAB1 -0.018 0.186 -9999.0 0.0 -0.483 5.0 5.0 VEGFR2 homodimer/VEGFA homodimer/Frs2/Nck/Pak 0.029 0.092 -9999.0 0.0 -9999.0 0.0 0.0 PRKACA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR2/3 heterodimer/VEGFC homodimer 0.012 0.079 -9999.0 0.0 -0.242 1.0 1.0 HSP90AA1 0.002 0.081 -9999.0 0.0 -0.411 2.0 2.0 CDC42 0.009 0.133 -9999.0 0.0 -0.383 4.0 4.0 actin cytoskeleton reorganization 0.007 0.099 -9999.0 0.0 -0.283 2.0 2.0 PTK2 0.0 0.129 -9999.0 0.0 -0.394 2.0 2.0 EDG1 -0.006 0.176 -9999.0 0.0 -0.504 5.0 5.0 mol:DAG 0.005 0.133 -9999.0 0.0 -0.379 4.0 4.0 CaM/Ca2+ 0.012 0.124 -9999.0 0.0 -0.344 4.0 4.0 MAP2K3 0.01 0.14 -9999.0 0.0 -0.406 4.0 4.0 VEGFR2 homodimer/VEGFA homodimer/GRB10/NEDD4 -0.001 0.19 -9999.0 0.0 -0.5 6.0 6.0 PLCG1 0.005 0.135 -9999.0 0.0 -0.383 4.0 4.0 VEGFR2 homodimer/VEGFA homodimer/Src/Shb 0.027 0.092 -9999.0 0.0 -0.262 2.0 2.0 IQGAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 YES1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR2 homodimer/VEGFA homodimer/SHP2 0.017 0.096 -9999.0 0.0 -0.285 2.0 2.0 VEGFR2 homodimer/VEGFA homodimer/SHP1 0.012 0.099 -9999.0 0.0 -0.285 2.0 2.0 cell migration 0.02 0.134 -9999.0 0.0 -0.384 1.0 1.0 mol:PI-3-4-5-P3 -0.014 0.167 -9999.0 0.0 -0.516 3.0 3.0 FYN -0.006 0.098 -9999.0 0.0 -0.411 3.0 3.0 VEGFB/NRP1 0.009 0.124 -9999.0 0.0 -0.356 4.0 4.0 mol:NO 0.02 0.114 -9999.0 0.0 -0.311 3.0 3.0 PXN 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HRAS/GTP -0.037 0.089 -9999.0 0.0 -0.314 4.0 4.0 VEGFR2 homodimer/VEGFA homodimer/GRB10 -0.004 0.189 -9999.0 0.0 -0.498 6.0 6.0 VHL 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ITGB3 -0.026 0.113 -9999.0 0.0 -0.315 7.0 7.0 NOS3 0.018 0.123 -9999.0 0.0 -0.344 3.0 3.0 VEGFR2 homodimer/VEGFA homodimer/Sck -0.011 0.107 -9999.0 0.0 -0.273 3.0 3.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCA 0.002 0.128 -9999.0 0.0 -0.351 4.0 4.0 PRKCB 0.002 0.124 -9999.0 0.0 -0.357 4.0 4.0 VCL 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 VEGFA165/NRP1 0.004 0.132 -9999.0 0.0 -0.383 4.0 4.0 VEGFR1/2 heterodimer/VEGFA homodimer 0.0 0.126 -9999.0 0.0 -0.398 3.0 3.0 VEGFA165/NRP2 -0.007 0.093 -9999.0 0.0 -0.263 6.0 6.0 MAPKKK cascade 0.02 0.162 -9999.0 0.0 -0.435 5.0 5.0 NRP2 -0.002 0.082 -9999.0 0.0 -0.337 3.0 3.0 VEGFC homodimer -0.024 0.118 -9999.0 0.0 -0.355 6.0 6.0 NCK1 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 ROCK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FAK1/Paxillin 0.009 0.124 -9999.0 0.0 -0.368 2.0 2.0 MAP3K13 0.009 0.133 -9999.0 0.0 -0.383 4.0 4.0 PDPK1 -0.008 0.151 -9999.0 0.0 -0.456 3.0 3.0