Class I PI3K signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations ARF5/GTP 0.03 0.063 0.209 4.0 -9999.0 0.0 4.0 DAPP1 -0.013 0.089 -9999.0 0.0 -0.296 2.0 2.0 Src family/SYK family/BLNK-LAT/BTK-ITK -0.026 0.162 -9999.0 0.0 -0.445 4.0 4.0 mol:DAG 0.001 0.092 0.184 2.0 -0.225 3.0 5.0 HRAS 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A -0.005 0.096 -9999.0 0.0 -0.401 3.0 3.0 ARF5/GDP -0.002 0.084 -9999.0 0.0 -0.258 2.0 2.0 PLCG2 -0.042 0.143 -9999.0 0.0 -0.383 8.0 8.0 PLCG1 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 ARF5 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.007 0.065 0.201 4.0 -9999.0 0.0 4.0 ARF1/GTP 0.008 0.062 0.197 4.0 -9999.0 0.0 4.0 RHOA 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 YES1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A/GTP 0.024 0.063 0.197 4.0 -0.169 2.0 6.0 ADAP1 0.007 0.062 0.193 4.0 -9999.0 0.0 4.0 ARAP3 0.007 0.064 0.2 4.0 -9999.0 0.0 4.0 INPPL1 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 PREX1 -0.052 0.156 -9999.0 0.0 -0.398 9.0 9.0 ARHGEF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARHGEF7 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NRAS 0.013 0.043 -9999.0 0.0 -0.298 1.0 1.0 FYN -0.006 0.098 -9999.0 0.0 -0.411 3.0 3.0 ARF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FGR 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.003 0.048 -9999.0 0.0 -0.131 1.0 1.0 mol:IP4 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 ZAP70 -0.02 0.106 -9999.0 0.0 -0.318 6.0 6.0 mol:IP3 -0.002 0.064 -9999.0 0.0 -0.165 3.0 3.0 LYN 0.012 0.043 -9999.0 0.0 -0.3 1.0 1.0 ARF1/GDP -0.002 0.084 -9999.0 0.0 -0.258 2.0 2.0 RhoA/GDP 0.019 0.071 0.208 3.0 -9999.0 0.0 3.0 PDK1/Src/Hsp90 0.026 0.05 -9999.0 0.0 -0.227 2.0 2.0 BLNK -0.006 0.098 -9999.0 0.0 -0.411 3.0 3.0 actin cytoskeleton reorganization 0.007 0.096 0.212 3.0 -0.259 2.0 5.0 SRC 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA2 0.013 0.034 -9999.0 0.0 -0.233 1.0 1.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTEN -0.022 0.117 -9999.0 0.0 -0.387 5.0 5.0 HSP90AA1 0.002 0.081 -9999.0 0.0 -0.411 2.0 2.0 ARF6/GTP 0.03 0.063 0.209 4.0 -9999.0 0.0 4.0 RhoA/GTP 0.026 0.068 0.198 4.0 -0.193 1.0 5.0 Src family/SYK family/BLNK-LAT -0.024 0.136 -9999.0 0.0 -0.4 4.0 4.0 BLK 0.004 0.071 -9999.0 0.0 -0.355 2.0 2.0 PDPK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYTH1 0.007 0.062 0.193 4.0 -9999.0 0.0 4.0 HCK -0.018 0.112 -9999.0 0.0 -0.366 5.0 5.0 CYTH3 0.007 0.062 0.193 4.0 -9999.0 0.0 4.0 CYTH2 0.007 0.062 0.193 4.0 -9999.0 0.0 4.0 KRAS 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GO:0030676 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FOXO3 0.028 0.056 0.158 4.0 -0.174 1.0 5.0 SGK1 0.001 0.058 0.159 4.0 -0.183 2.0 6.0 INPP5D -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.011 0.087 -9999.0 0.0 -0.246 3.0 3.0 SOS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SYK -0.012 0.106 -9999.0 0.0 -0.383 4.0 4.0 ARF6/GDP 0.02 0.067 0.211 3.0 -9999.0 0.0 3.0 mol:PI-3-4-5-P3 0.01 0.072 0.231 4.0 -9999.0 0.0 4.0 ARAP3/RAP1A/GTP 0.024 0.063 0.198 4.0 -0.169 2.0 6.0 VAV1 -0.047 0.138 -9999.0 0.0 -0.333 10.0 10.0 mol:PI-3-4-P2 0.006 0.04 -9999.0 0.0 -0.288 1.0 1.0 RAS family/GTP/PI3K Class I 0.032 0.059 0.18 4.0 -0.167 2.0 6.0 PLEKHA1 0.005 0.053 -9999.0 0.0 -0.209 3.0 3.0 Rac1/GDP -0.002 0.084 -9999.0 0.0 -0.258 2.0 2.0 LAT -0.008 0.091 -9999.0 0.0 -0.327 4.0 4.0 Rac1/GTP -0.011 0.102 -9999.0 0.0 -0.33 3.0 3.0 ITK 0.014 0.076 0.2 4.0 -9999.0 0.0 4.0 Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma -0.006 0.12 0.21 2.0 -0.318 3.0 5.0 LCK -0.022 0.113 -9999.0 0.0 -0.337 6.0 6.0 BTK 0.022 0.069 0.2 4.0 -9999.0 0.0 4.0