HIF-2-alpha transcription factor network Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MMP14 -0.017 0.157 -9999.0 0.0 -1.147 1.0 1.0 oxygen homeostasis 0.003 0.015 -9999.0 0.0 -9999.0 0.0 0.0 TCEB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TCEB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VHL/Elongin B/Elongin C/HIF2A 0.017 0.143 -9999.0 0.0 -0.421 3.0 3.0 EPO 0.024 0.229 -9999.0 0.0 -0.5 3.0 3.0 FIH (dimer) 0.02 0.015 -9999.0 0.0 -9999.0 0.0 0.0 APEX1 0.02 0.018 -9999.0 0.0 -9999.0 0.0 0.0 SERPINE1 0.007 0.255 -9999.0 0.0 -0.541 6.0 6.0 FLT1 -0.073 0.282 -9999.0 0.0 -1.061 4.0 4.0 ADORA2A 0.007 0.236 -9999.0 0.0 -0.493 6.0 6.0 germ cell development -0.014 0.268 -9999.0 0.0 -0.577 6.0 6.0 SLC11A2 0.007 0.256 -9999.0 0.0 -0.563 6.0 6.0 BHLHE40 0.004 0.24 -9999.0 0.0 -0.515 6.0 6.0 HIF1AN 0.02 0.015 -9999.0 0.0 -9999.0 0.0 0.0 HIF2A/ARNT/SIRT1 0.018 0.182 -9999.0 0.0 -0.476 3.0 3.0 ETS1 0.024 0.046 -9999.0 0.0 -0.291 1.0 1.0 CITED2 -0.002 0.046 -9999.0 0.0 -9999.0 0.0 0.0 KDR -0.005 0.052 -9999.0 0.0 -9999.0 0.0 0.0 PGK1 0.008 0.246 -9999.0 0.0 -0.509 6.0 6.0 SIRT1 0.018 0.001 -9999.0 0.0 -9999.0 0.0 0.0 response to hypoxia 0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 HIF2A/ARNT 0.028 0.284 -9999.0 0.0 -0.585 6.0 6.0 EPAS1 0.001 0.158 -9999.0 0.0 -0.428 4.0 4.0 SP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABCG2 -0.002 0.265 -9999.0 0.0 -0.556 7.0 7.0 EFNA1 -0.008 0.276 -9999.0 0.0 -0.615 6.0 6.0 FXN 0.01 0.233 -9999.0 0.0 -0.493 6.0 6.0 POU5F1 -0.017 0.276 -9999.0 0.0 -0.6 6.0 6.0 neuron apoptosis -0.027 0.278 0.57 6.0 -9999.0 0.0 6.0 EP300 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 EGLN3 -0.055 0.16 -9999.0 0.0 -0.385 10.0 10.0 EGLN2 0.012 0.06 -9999.0 0.0 -0.411 1.0 1.0 EGLN1 0.014 0.047 -9999.0 0.0 -0.312 1.0 1.0 VHL/Elongin B/Elongin C 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VHL 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARNT 0.02 0.018 -9999.0 0.0 -9999.0 0.0 0.0 SLC2A1 0.003 0.245 -9999.0 0.0 -0.506 7.0 7.0 TWIST1 -0.009 0.25 -9999.0 0.0 -0.502 7.0 7.0 ELK1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 HIF2A/ARNT/Cbp/p300 0.017 0.182 -9999.0 0.0 -0.474 3.0 3.0 VEGFA -0.001 0.258 -9999.0 0.0 -0.499 8.0 8.0 CREBBP 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0