Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.168 0.228 -9999.0 0.0 -0.556 11.0 11.0 IHH -0.239 0.212 -9999.0 0.0 -0.398 33.0 33.0 SHH Np/Cholesterol/GAS1 -0.075 0.119 -9999.0 0.0 -0.226 16.0 16.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.074 0.118 0.225 16.0 -9999.0 0.0 16.0 SMO/beta Arrestin2 -0.158 0.205 -9999.0 0.0 -0.427 15.0 15.0 SMO -0.173 0.214 -9999.0 0.0 -0.454 15.0 15.0 AKT1 -0.096 0.166 -9999.0 0.0 -0.564 4.0 4.0 ARRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.03 0.113 -9999.0 0.0 -0.3 8.0 8.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.171 0.211 -9999.0 0.0 -0.448 15.0 15.0 STIL -0.125 0.163 -9999.0 0.0 -0.339 16.0 16.0 DHH N/PTCH2 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.12 0.152 -9999.0 0.0 -0.356 11.0 11.0 PIK3CA 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 DHH 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.2 0.266 -9999.0 0.0 -0.639 11.0 11.0 determination of left/right symmetry -0.171 0.211 -9999.0 0.0 -0.448 15.0 15.0 PIK3R1 -0.038 0.134 -9999.0 0.0 -0.355 8.0 8.0 skeletal system development -0.199 0.263 -9999.0 0.0 -0.633 11.0 11.0 IHH N/Hhip -0.182 0.158 -9999.0 0.0 -0.304 29.0 29.0 DHH N/Hhip -0.032 0.111 -9999.0 0.0 -0.237 12.0 12.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.171 0.211 -9999.0 0.0 -0.448 15.0 15.0 pancreas development -0.065 0.157 -9999.0 0.0 -0.355 12.0 12.0 HHAT -0.052 0.156 -9999.0 0.0 -0.398 9.0 9.0 PI3K -0.018 0.112 -9999.0 0.0 -0.268 8.0 8.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.107 0.179 -9999.0 0.0 -0.355 18.0 18.0 somite specification -0.171 0.211 -9999.0 0.0 -0.448 15.0 15.0 SHH Np/Cholesterol/PTCH1 -0.131 0.164 -9999.0 0.0 -0.351 15.0 15.0 SHH Np/Cholesterol/PTCH2 -0.01 0.084 -9999.0 0.0 -0.204 8.0 8.0 SHH Np/Cholesterol/Megalin -0.021 0.096 -9999.0 0.0 -0.222 8.0 8.0 SHH -0.026 0.11 -9999.0 0.0 -0.27 9.0 9.0 catabolic process -0.145 0.17 -9999.0 0.0 -0.406 11.0 11.0 SMO/Vitamin D3 -0.153 0.195 -9999.0 0.0 -0.412 15.0 15.0 SHH Np/Cholesterol/Hhip -0.053 0.112 -9999.0 0.0 -0.22 13.0 13.0 LRP2 -0.006 0.083 -9999.0 0.0 -0.3 4.0 4.0 receptor-mediated endocytosis -0.144 0.189 -9999.0 0.0 -0.392 15.0 15.0 SHH Np/Cholesterol/BOC -0.033 0.11 -9999.0 0.0 -0.258 8.0 8.0 SHH Np/Cholesterol/CDO -0.021 0.096 -9999.0 0.0 -0.222 8.0 8.0 mesenchymal cell differentiation 0.053 0.111 0.219 13.0 -9999.0 0.0 13.0 mol:Vitamin D3 -0.131 0.165 -9999.0 0.0 -0.353 15.0 15.0 IHH N/PTCH2 -0.123 0.126 -9999.0 0.0 -0.251 23.0 23.0 CDON -0.006 0.083 -9999.0 0.0 -0.3 4.0 4.0 IHH N/PTCH1 -0.145 0.173 -9999.0 0.0 -0.41 11.0 11.0 Megalin/LRPAP1 0.01 0.058 -9999.0 0.0 -0.194 4.0 4.0 PTCH2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.019 0.083 -9999.0 0.0 -0.211 8.0 8.0 PTCH1 -0.145 0.17 -9999.0 0.0 -0.407 11.0 11.0 HHIP -0.065 0.157 -9999.0 0.0 -0.355 12.0 12.0