IL27-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CD4-positive alpha-beta T cell lineage commitment -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cytokine production during immune response 0.082 0.247 0.744 5.0 -0.505 1.0 6.0 IL27/IL27R/JAK1 -0.129 0.351 0.47 1.0 -1.159 5.0 6.0 TBX21 -0.145 0.25 0.404 1.0 -0.531 11.0 12.0 IL12B 0.016 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IL12A 0.001 0.049 -9999.0 0.0 -0.245 2.0 2.0 IL6ST 0.002 0.063 -9999.0 0.0 -0.312 2.0 2.0 IL27RA/JAK1 -0.115 0.367 -9999.0 0.0 -1.239 5.0 5.0 IL27 -0.038 0.137 -9999.0 0.0 -0.388 7.0 7.0 TYK2 0.014 0.015 -9999.0 0.0 -9999.0 0.0 0.0 T-helper cell lineage commitment 0.024 0.051 -9999.0 0.0 -9999.0 0.0 0.0 T-helper 2 cell differentiation 0.082 0.247 0.744 5.0 -0.505 1.0 6.0 T cell proliferation during immune response 0.082 0.247 0.744 5.0 -0.505 1.0 6.0 MAPKKK cascade -0.082 0.247 0.505 1.0 -0.744 5.0 6.0 STAT3 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 STAT2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 -0.032 0.119 -9999.0 0.0 -0.316 8.0 8.0 IL12RB1 0.009 0.058 -9999.0 0.0 -0.411 1.0 1.0 positive regulation of tyrosine phosphorylation of STAT protein 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL12RB2 -0.121 0.235 0.406 1.0 -0.57 8.0 9.0 IL27/IL27R/JAK2/TYK2 -0.084 0.252 0.506 1.0 -0.759 5.0 6.0 positive regulation of T cell mediated cytotoxicity -0.082 0.247 0.505 1.0 -0.744 5.0 6.0 STAT1 (dimer) -0.19 0.326 0.553 1.0 -0.983 6.0 7.0 JAK2 0.003 0.063 -9999.0 0.0 -0.309 2.0 2.0 JAK1 -0.031 0.135 -9999.0 0.0 -0.412 6.0 6.0 STAT2 (dimer) -0.072 0.237 0.439 1.0 -0.713 5.0 6.0 T cell proliferation -0.091 0.236 0.469 1.0 -0.71 5.0 6.0 IL12/IL12R/TYK2/JAK2 0.004 0.074 -9999.0 0.0 -9999.0 0.0 0.0 IL17A 0.024 0.051 -9999.0 0.0 -9999.0 0.0 0.0 mast cell activation 0.082 0.247 0.744 5.0 -0.505 1.0 6.0 IFNG -0.012 0.043 0.143 1.0 -0.092 4.0 5.0 T cell differentiation -0.007 0.008 -9999.0 0.0 -0.02 13.0 13.0 STAT3 (dimer) -0.076 0.237 0.439 1.0 -0.713 5.0 6.0 STAT5A (dimer) -0.072 0.237 0.439 1.0 -0.713 5.0 6.0 STAT4 (dimer) -0.072 0.237 0.439 1.0 -0.713 5.0 6.0 STAT4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 T cell activation 0.003 0.038 0.123 5.0 -9999.0 0.0 5.0 IL27R/JAK2/TYK2 -0.085 0.322 0.412 1.0 -1.053 5.0 6.0 GATA3 0.011 0.097 -9999.0 0.0 -0.42 1.0 1.0 IL18 -0.017 0.082 -9999.0 0.0 -0.246 6.0 6.0 positive regulation of mast cell cytokine production -0.074 0.23 0.435 1.0 -0.694 5.0 6.0 IL27/EBI3 -0.028 0.112 0.186 1.0 -0.27 9.0 10.0 IL27RA -0.104 0.36 0.424 1.0 -1.214 5.0 6.0 IL6 -0.02 0.112 -9999.0 0.0 -0.289 8.0 8.0 STAT5A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 monocyte differentiation -0.001 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IL2 0.028 0.213 0.484 5.0 -1.152 1.0 6.0 IL1B -0.019 0.086 -9999.0 0.0 -0.26 6.0 6.0 EBI3 -0.002 0.083 -9999.0 0.0 -0.415 2.0 2.0 TNF -0.014 0.073 -9999.0 0.0 -0.217 6.0 6.0