Signaling events mediated by Stem cell factor receptor (c-Kit) Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MAP4K1 -0.093 0.168 -9999.0 0.0 -0.378 11.0 11.0 CRKL -0.104 0.177 -9999.0 0.0 -0.406 11.0 11.0 HRAS -0.071 0.157 -9999.0 0.0 -0.339 10.0 10.0 mol:PIP3 -0.094 0.165 0.269 1.0 -0.336 13.0 14.0 SPRED1 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 SPRED2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAB1 -0.115 0.186 -9999.0 0.0 -0.389 14.0 14.0 FOXO3 -0.089 0.17 -9999.0 0.0 -0.376 11.0 11.0 AKT1 -0.102 0.182 -9999.0 0.0 -0.41 11.0 11.0 BAD -0.091 0.172 -9999.0 0.0 -0.37 12.0 12.0 megakaryocyte differentiation -0.123 0.185 -9999.0 0.0 -0.408 13.0 13.0 GSK3B -0.089 0.17 -9999.0 0.0 -0.376 11.0 11.0 RAF1 -0.054 0.136 -9999.0 0.0 -0.287 10.0 10.0 SHC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 -0.111 0.186 -9999.0 0.0 -0.406 13.0 13.0 STAT1 -0.26 0.432 -9999.0 0.0 -0.892 15.0 15.0 HRAS/SPRED1 -0.055 0.133 -9999.0 0.0 -0.277 10.0 10.0 cell proliferation -0.112 0.181 -9999.0 0.0 -0.392 13.0 13.0 PIK3CA 0.009 0.058 -9999.0 0.0 -0.412 1.0 1.0 TEC 0.012 0.043 -9999.0 0.0 -0.3 1.0 1.0 RPS6KB1 -0.11 0.187 -9999.0 0.0 -0.414 12.0 12.0 HRAS/SPRED2 -0.052 0.134 -9999.0 0.0 -0.277 10.0 10.0 LYN/TEC/p62DOK -0.089 0.176 -9999.0 0.0 -0.387 11.0 11.0 MAPK3 -0.029 0.103 -9999.0 0.0 -0.228 4.0 4.0 STAP1 -0.109 0.185 -9999.0 0.0 -0.39 14.0 14.0 GRAP2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 -0.209 0.348 -9999.0 0.0 -0.72 15.0 15.0 STAT1 (dimer) -0.254 0.422 -9999.0 0.0 -0.872 15.0 15.0 mol:Gleevec 0.004 0.008 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOCS1/VAV1 -0.112 0.189 -9999.0 0.0 -0.405 13.0 13.0 actin filament polymerization -0.111 0.179 -9999.0 0.0 -0.344 18.0 18.0 LYN 0.012 0.043 -9999.0 0.0 -0.3 1.0 1.0 STAP1/STAT5A (dimer) -0.142 0.251 -9999.0 0.0 -0.495 16.0 16.0 PIK3R1 -0.038 0.134 -9999.0 0.0 -0.355 8.0 8.0 CBL/CRKL/GRB2 -0.081 0.167 -9999.0 0.0 -0.362 11.0 11.0 PI3K -0.117 0.186 -9999.0 0.0 -0.383 15.0 15.0 PTEN -0.022 0.124 -9999.0 0.0 -0.41 5.0 5.0 SCF/KIT/EPO/EPOR -0.274 0.493 -9999.0 0.0 -1.174 11.0 11.0 MAPK8 -0.114 0.184 -9999.0 0.0 -0.4 13.0 13.0 STAT3 (dimer) -0.108 0.183 -9999.0 0.0 -0.399 13.0 13.0 positive regulation of transcription -0.022 0.087 -9999.0 0.0 -0.187 4.0 4.0 mol:GDP -0.082 0.166 -9999.0 0.0 -0.355 11.0 11.0 PIK3C2B -0.111 0.181 -9999.0 0.0 -0.406 12.0 12.0 CBL/CRKL -0.09 0.17 -9999.0 0.0 -0.378 11.0 11.0 FER -0.107 0.182 -9999.0 0.0 -0.38 14.0 14.0 SH2B3 -0.107 0.182 -9999.0 0.0 -0.406 12.0 12.0 PDPK1 -0.083 0.154 0.244 1.0 -0.319 12.0 13.0 SNAI2 -0.114 0.189 -9999.0 0.0 -0.422 12.0 12.0 positive regulation of cell proliferation -0.184 0.308 -9999.0 0.0 -0.638 15.0 15.0 KITLG -0.02 0.096 -9999.0 0.0 -0.315 5.0 5.0 cell motility -0.184 0.308 -9999.0 0.0 -0.638 15.0 15.0 PTPN6 0.016 0.058 -9999.0 0.0 -0.399 1.0 1.0 EPOR -0.068 0.159 -9999.0 0.0 -0.543 1.0 1.0 STAT5A (dimer) -0.147 0.254 -9999.0 0.0 -0.504 16.0 16.0 SOCS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell migration 0.111 0.18 0.398 12.0 -9999.0 0.0 12.0 SOS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EPO 0.007 0.045 -9999.0 0.0 -0.315 1.0 1.0 VAV1 -0.047 0.138 -9999.0 0.0 -0.333 10.0 10.0 GRB10 -0.124 0.203 -9999.0 0.0 -0.452 12.0 12.0 PTPN11 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SCF/KIT -0.119 0.191 -9999.0 0.0 -0.367 18.0 18.0 GO:0007205 0.006 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 -0.037 0.112 -9999.0 0.0 -0.248 5.0 5.0 CBL 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KIT -0.261 0.494 -9999.0 0.0 -1.26 10.0 10.0 MAP2K2 -0.037 0.112 -9999.0 0.0 -0.248 5.0 5.0 SHC/Grb2/SOS1 -0.084 0.177 -9999.0 0.0 -0.387 11.0 11.0 STAT5A -0.151 0.261 -9999.0 0.0 -0.531 15.0 15.0 GRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to radiation -0.112 0.185 -9999.0 0.0 -0.413 12.0 12.0 SHC/GRAP2 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTPRO -0.126 0.189 -9999.0 0.0 -0.417 13.0 13.0 SH2B2 -0.113 0.182 -9999.0 0.0 -0.35 18.0 18.0 DOK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MATK -0.113 0.183 -9999.0 0.0 -0.406 12.0 12.0 CREBBP -0.001 0.06 -9999.0 0.0 -9999.0 0.0 0.0 BCL2 -0.213 0.466 -9999.0 0.0 -1.297 8.0 8.0