Hybridization REF p difference q subclass Composite Element REF p difference q subclass CCNB1|CYCLIN_B1-R-V 9.96552748707885e-39 1.28418150785585 7.11754317995109e-38 1 MSH6|MSH6-R-C 1.11529117164233e-22 0.806034310048532 1.70691267242609e-22 1 SYK|SYK-M-V 6.11164188173259e-19 0.707956567192463 5.23804184575644e-19 1 CASP7|CASPASE-7_CLEAVEDD198-R-C 1.07153613674546e-12 0.68181576176204 6.55978871626854e-13 1 CCNE1|CYCLIN_E1-M-V 3.09591383182433e-18 0.617340985924222 2.4568360400377e-18 1 TP53|P53-R-V 4.31843829350525e-21 0.578997780564988 5.44288139592102e-21 1 RPS6|S6-R-NA 1.91353830170145e-31 0.541407128578795 8.2000826387822e-31 1 MSH2|MSH2-M-C 2.42931345432817e-18 0.527088630262725 2.00198713066339e-18 1 RPS6|S6_PS235_S236-R-V 2.08413731893628e-09 0.493889091061008 8.93115033582111e-10 1 EGFR|EGFR_PY1068-R-V 3.36016346598706e-05 0.493674577408322 8.88845873636645e-06 1 CHEK2|CHK2_PT68-R-C 5.94342105304828e-23 0.492319407441602 9.7958972228284e-23 1 ERBB2|HER2-M-V 0.000641353795989269 0.475393137330804 0.000146191085170414 1 RPS6|S6_PS240_S244-R-V 3.93696231523496e-12 0.446774982296968 2.23796011308194e-12 1 CDH3|P-CADHERIN-R-C 8.07812853789157e-18 0.440117249429238 6.18164131547341e-18 1 CHEK2|CHK2-M-C 1.64833159995951e-17 0.432532602946952 1.1772654636497e-17 1 SRC|SRC_PY416-R-C 1.38043705400496e-17 0.392939564135898 1.01992839835995e-17 1 ERBB2|HER2_PY1248-R-V 0.000462479933905153 0.391592597286862 0.000107710028516418 1 RB1|RB_PS807_S811-R-V 1.54042161166465e-07 0.369852711095028 5.59420871254471e-08 1 NFKB1|NF-KB-P65_PS536-R-C 6.10948094126521e-08 0.360690975878725 2.33758472803898e-08 1 PECAM1|CD31-M-V 6.72408923145853e-11 0.327908140283789 3.43032486688332e-11 1 EGFR|EGFR-R-C 4.68898439104729e-05 0.326071880815348 1.21046369567376e-05 1 CDC2|CDK1-R-V 1.18922052243046e-20 0.3098983670221 1.27404120301572e-20 1 GSK3A GSK3B|GSK3-ALPHA-BETA-M-V 3.37993202858037e-10 0.307377022380076 1.60933526030356e-10 1 CDKN1B|P27_PT198-R-V 6.8071744643952e-21 0.306364391240514 7.67651944691811e-21 1 EIF4EBP1|4E-BP1_PT37-R-V 7.74795975121612e-06 0.302303490054714 2.33819152046424e-06 1 WWTR1|TAZ_PS89-R-C 7.84512484120135e-10 0.283169705377929 3.50194802042317e-10 1 EEF2|EEF2-R-V 7.0651602388753e-28 0.277853474232036 1.89226999544189e-27 1 AKT1 AKT2 AKT3|AKT_PT308-R-V 0.000696364776271415 0.272745083018917 0.000157059519339681 1 EIF4EBP1|4E-BP1_PS65-R-V 2.65390649475725e-19 0.26763198547566 2.3693294329476e-19 1 AKT1 AKT2 AKT3|AKT_PS473-R-V 0.0075579646802727 0.267397225615111 0.00154229209597456 1 XRCC5|KU80-R-C 1.34834457628849e-08 0.261927288118239 5.55582583346752e-09 1 EIF4EBP1|4E-BP1-R-V 1.5973044069483e-05 0.255136681360604 4.56328402193317e-06 1 KIT|C-KIT-R-V 0.0252167882065923 0.236554828113094 0.00478148063574498 1 AKT1S1|PRAS40_PT246-R-V 1.71820122003156e-14 0.231817622317033 1.1504695239987e-14 1 ATM|ATM-R-NA 0.000218388839193587 0.23074061431955 5.14209530230058e-05 1 TGM2|TRANSGLUTAMINASE-M-V 5.47464276399629e-11 0.229509919192241 2.86103389309331e-11 1 LCK|LCK-R-V 0.000203239127747672 0.222278368165328 4.83855728150615e-05 1 ARAF|A-RAF_PS299-R-NA 3.64627355666246e-09 0.20272808437034 1.53189904599268e-09 1 SHC1|SHC_PY317-R-NA 0.000168555615269655 0.19526259826565 4.05792758342547e-05 1 YBX1|YB-1_PS102-R-V 5.36332785263905e-06 0.19367539005353 1.66546813847027e-06 1 DVL3|DVL3-R-V 3.81966447837981e-08 0.181864261573169 1.53257924632251e-08 1 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9-R-V 0.0292210086823119 0.168020247207715 0.00539744577584076 1 BIRC2 |CIAP-R-V 1.6586382001882e-07 0.166959443867693 5.9231330328789e-08 1 EIF4EBP1|4E-BP1_PT170-R-V 3.75036066831174e-10 0.161804227727502 1.74689289163215e-10 1 PTGS2|COX-2-R-C 0.0121884799043629 0.156398228028024 0.00237414879707026 1 SNAI2|SNAIL-M-C 1.39453997870895e-06 0.151191063640025 4.59693842405858e-07 1 EGFR|EGFR_PY992-R-V 0.00171085349384121 0.145713575095213 0.000370278674456691 1 MET|C-MET_PY1235-R-C 2.47824361694491e-07 0.145556289789287 8.5645269576098e-08 1 CDKN1B|P27_PT157-R-C 3.2147343803326e-12 0.143185136903602 1.91334668383567e-12 1 NOTCH1|NOTCH1-R-V 7.90749479791936e-06 0.138473374139711 2.35319269946673e-06 1 RAF1|C-RAF-R-V 4.50032696104816e-05 0.131086492803206 1.17592950997973e-05 1 BECN1|BECLIN-G-V 1.92818946383623e-05 0.124123243322845 5.36549820815601e-06 1 PARP1|PARP_CLEAVED-M-C 2.5360266377477e-05 0.120759829952912 6.96643007340869e-06 1 CHEK1|CHK1_PS345-R-C 4.81954404487234e-08 0.119257193010439 1.87756222044801e-08 1 YBX1|YB-1-R-V 0.00179668860544401 0.109826918918595 0.000384967341069138 1 ERCC1|ERCC1-M-C 1.4812010528752e-07 0.104406185949506 5.47188665040951e-08 1 ANLN|ANLN-M-NA 8.06577313753348e-06 0.101776274817569 2.36741402665485e-06 1 NCOA3|AIB1-M-V 0.00220818048224581 0.100443345016288 0.000463858446378926 1 MRE11A|MRE11-R-C 0.00196602123069421 0.0942438295750935 0.000417078596577499 1 MYC|C-MYC-R-C 0.0083681086554441 0.0895222968082405 0.00169150201428679 1 PRKCD|PKC-DELTA_PS664-R-V 8.97656964705835e-05 0.0857756250530856 2.23646974545618e-05 1 RAB25|RAB25-R-C 0.0322260574100094 0.0808477987553768 0.00590163557818852 1 VASP|VASP-R-C 0.0243185735319803 0.0798605200550105 0.0046523368059053 1 RPS6KA1|P90RSK_PT359_S363-R-C 0.0412027961743027 0.0733344475111243 0.00735692820288647 1 NF2|NF2-R-C 0.0113800875419549 0.0729341735966387 0.00223702160695039 1 CTNNA1|ALPHA-CATENIN-M-V 0.0421937612507627 0.0704086902126383 0.00747160569976261 1 CHEK1|CHK1-R-V 0.0109949304764807 0.0582230116274757 0.00220085146845044 1 FOXO3|FOXO3A_PS318_S321-R-C 0.0432146700633246 0.0427038331382298 0.00758966216573342 1 XRCC1|XRCC1-R-C 0.00150329395591679 -0.0662295058067598 0.000328676693710057 1 YAP1|YAP-R-V 0.0358873572698311 -0.0679804713673046 0.0064616821425105 1 BCL2L1|BCL-XL-R-C 7.42040771029171e-05 -0.0735573626831896 1.8705094912315e-05 1 RPS6KB1|P70S6K_PT389-R-V 0.0185706116699644 -0.0740030681636616 0.00358471228077352 1 CASP9|CASPASE-9_CLEAVEDD330-R-C 0.0110933678795465 -0.0758219182512864 0.00220085146845044 1 XIAP|XIAP-R-C 0.000113393423573591 -0.0865752725796469 2.79267044579415e-05 1 KRAS|K-RAS-M-C 1.85879750863841e-06 -0.116019239061637 6.03447121620611e-07 1 CDH2|N-CADHERIN-R-V 2.80544310492859e-05 -0.122332784680228 7.60896257755509e-06 1 CASP8|CASPASE-8-M-C 1.97177342475722e-06 -0.123654277123089 6.30569964099161e-07 1 STAT3|STAT3_PY705-R-V 0.000475458913459569 -0.12457905867138 0.000109542114254295 1 BAX|BAX-R-V 0.000143435533132281 -0.124634995560138 3.49240944230912e-05 1 DIABLO|SMAC-M-V 0.00438752534415985 -0.128280298769148 0.00091271142593912 1 MET|C-MET-M-C 1.50870534446647e-09 -0.128751458630733 6.5971965423026e-10 1 SRC|SRC_PY527-R-V 0.0356904911813616 -0.140045631191723 0.0064616821425105 1 BID|BID-R-C 3.86247450764679e-08 -0.14381037507278 1.53257924632251e-08 1 MAPK14|P38_MAPK-R-C 6.19642592571882e-06 -0.145225846108244 1.89668101125272e-06 1 PRKAA1|AMPK_ALPHA-R-C 1.99515791120265e-07 -0.151770961648577 7.00807132907844e-08 1 YWHAE|14-3-3_EPSILON-M-C 1.75527502443556e-13 -0.152870586464184 1.13967837403018e-13 1 EGFR|EGFR_PY1173-R-C 1.0289688589547e-07 -0.158993714586533 3.86792860843802e-08 1 SMAD4|SMAD4-M-C 6.20032628996783e-13 -0.159779863636175 3.90738946797745e-13 1 RAD50|RAD50-M-C 9.37900307546393e-12 -0.162704891334321 5.02397836901228e-12 1 MAPT|TAU-M-C 0.006779908406948 -0.171858316225965 0.00139682359162047 1 BAK1|BAK-R-C 4.15324191978172e-10 -0.171991164822752 1.89339159454606e-10 1 BCL2L1|BCL-X-R-C 3.96903441447607e-12 -0.175909146596083 2.23796011308194e-12 1 PDK1|PDK1_PS241-R-V 4.46142352171036e-06 -0.178261487391034 1.40577434683751e-06 1 PTK2|FAK-R-C 0.00100099730476206 -0.181597898673565 0.000223415216508118 1 PRKAA1|AMPK_PT172-R-V 0.00112006739285484 -0.196057419883501 0.000247413557523371 1 PTCH1|PTCH-R-C 1.68969585957975e-05 -0.204968414999112 4.76371774856273e-06 1 PEA15|PEA-15-R-V 5.88234118161858e-12 -0.205071629506497 3.23174196199077e-12 1 EEF2K|EEF2K-R-V 9.51215139957575e-06 -0.218136103886795 2.7542167063177e-06 1 ERBB3|HER3-M-C 5.79825736836401e-07 -0.220631143220375 1.9411924275322e-07 1 FN1|FIBRONECTIN-R-C 0.0270773240653784 -0.224698664175842 0.00504497450966739 1 HSPA1A|HSP70-R-C 0.0257029748858982 -0.230633629188687 0.0048309174285471 1 SMAD3|SMAD3-R-V 1.460179459221e-24 -0.255401758344242 2.84422941483895e-24 1 IRS1|IRS1-R-V 5.13331888017335e-20 -0.259076429347573 5.23757219696525e-20 1 CDKN1B|P27-R-V 1.8581837938699e-10 -0.288164101895347 9.04871824371742e-11 1 RB1|RB-M-V 1.9883149482787e-19 -0.289073726049828 1.85228758333666e-19 1 KDR|VEGFR2-R-C 3.01993968150076e-05 -0.318944581944324 8.08833919421183e-06 1 BCL2L11|BIM-R-V 8.5156381771403e-11 -0.354914064464924 4.24326171248879e-11 1 MAPK9|JNK2-R-C 1.68891196658166e-22 -0.368561604031985 2.26171617574945e-22 1 PARK7|DJ-1-R-C 1.61460264556926e-22 -0.434850907951912 2.26171617574945e-22 1 ESR1|ER-ALPHA_PS118-R-V 5.46093090788215e-27 -0.519006800563358 1.30009547378791e-26 1 MAPK1 MAPK3|MAPK_PT202_Y204-R-V 5.41877560336014e-05 -0.529313617628586 1.38220657552421e-05 1 CCND1|CYCLIN_D1-R-V 6.20318401181549e-25 -0.567996947582238 1.32912472865661e-24 1 IGFBP2|IGFBP2-R-V 3.54935635483487e-07 -0.608290211957206 1.20714691574464e-07 1 INPP4B|INPP4B-G-C 5.04189538211981e-24 -0.71873389653378 9.00251094022942e-24 1 IGF1R|IGF-1R-BETA-R-C 1.97669780099413e-17 -0.794028390818125 1.3662483775128e-17 1 AR|AR-R-V 6.61210432596845e-20 -0.971074989559397 6.43973639648938e-20 1 COL6A1|COLLAGEN_VI-R-V 4.84641531468927e-21 -1.08177778197657 5.76898217630765e-21 1 BCL2|BCL-2-M-V 3.07550431135839e-29 -1.28597218151238 1.09828781088615e-28 1 GATA3|GATA3-M-V 9.65160077461581e-29 -1.43198629218461 2.95428495988714e-28 1 CAV1|CAVEOLIN-1-R-V 2.33965625877138e-34 -1.50952401785592 1.25326565525304e-33 1 PGR|PR-R-V 1.45361689252794e-55 -2.93035091883985 3.1145910780203e-54 1 ESR1|ER-ALPHA-R-V 1.37424739377863e-49 -3.51066785815807 1.47226504234275e-48 1 ESR1|ER-ALPHA-R-V 1.2262771438093e-71 3.59761543646376 3.82741238602939e-70 2 PGR|PR-R-V 2.57625756991013e-28 2.74643212812192 1.17002309725522e-27 2 GATA3|GATA3-M-V 1.89666129886096e-59 1.71838725589087 2.95989572341403e-58 2 BCL2|BCL-2-M-V 2.62407262669452e-28 1.15711849162291 1.17002309725522e-27 2 AR|AR-R-V 1.13579533077854e-32 1.0345561626966 8.8625094640355e-32 2 IGF1R|IGF-1R-BETA-R-C 1.09515209754282e-22 0.934998551900047 2.01067622287996e-22 2 INPP4B|INPP4B-G-C 1.17639727979652e-29 0.928026702128997 7.34345827501566e-29 2 CDH1|E-CADHERIN-R-V 5.35239938557151e-18 0.890220882319437 5.76059228696935e-18 2 ESR1|ER-ALPHA_PS118-R-V 2.99522126911924e-36 0.839253027155646 3.11619251874121e-35 2 KDR|VEGFR2-R-C 1.68592424793513e-24 0.825984302439253 5.84671832956627e-24 2 CLDN7|CLAUDIN-7-R-V 1.42482115592308e-11 0.687013775071018 9.66761056384177e-12 2 FRAP1|MTOR-R-V 8.34978067298095e-24 0.621129426997249 2.36918517820989e-23 2 TP53BP1|53BP1-R-C 1.93214256182348e-23 0.590321835328082 4.66433408171859e-23 2 CTNNB1|BETA-CATENIN-R-V 2.31899993745651e-15 0.588818276574822 2.06799420241305e-15 2 IGFBP2|IGFBP2-R-V 3.55136401402906e-08 0.557741510264209 1.60643339296067e-08 2 BRAF|B-RAF-M-NA 4.01160207945742e-16 0.539379985231558 3.68260853214749e-16 2 BCL2L11|BIM-R-V 1.10863240251422e-18 0.49696076690762 1.23579422317775e-18 2 EEF2K|EEF2K-R-V 1.94526611487936e-23 0.489247661437574 4.66433408171859e-23 2 TSC2|TUBERIN-R-C 2.09218970365783e-23 0.40274112670907 4.66433408171859e-23 2 PDK1|PDK1_PS241-R-V 5.91677862388883e-24 0.376699985748366 1.8467237936213e-23 2 ACACA|ACC1-R-C 1.17417109904673e-05 0.374380055687851 4.02723171618677e-06 2 MAPK9|JNK2-R-C 1.95954282021439e-22 0.370926015247812 3.39780833526462e-22 2 RPS6KB1|P70S6K-R-V 3.26731116489402e-07 0.361053835442182 1.29086263451007e-07 2 PRKAA1|AMPK_PT172-R-V 1.26258484920146e-09 0.351792958501447 6.4602208167585e-10 2 RBM3|RBM3-M-NA 3.24442108870576e-10 0.348310284310221 1.94737906251402e-10 2 DIABLO|SMAC-M-V 8.86183326095109e-15 0.34017662182835 7.68312144270737e-15 2 GSK3A GSK3B|GSK3-ALPHA-BETA-M-V 5.1514171191546e-10 0.301941626610331 2.92334890303666e-10 2 PTEN|PTEN-R-V 7.91159792855039e-10 0.295515152160397 4.25748217964341e-10 2 ACACA ACACB|ACC_PS79-R-V 0.000295784411492259 0.293175193065909 8.79230220823897e-05 2 PARK7|DJ-1-R-C 2.81858915232663e-10 0.288772154245026 1.72495680535033e-10 2 AKT1 AKT2 AKT3|AKT-R-V 1.62843666000086e-08 0.27132745278441 7.58599745094705e-09 2 STAT5A|STAT5-ALPHA-R-V 0.000191684005447368 0.270170147072804 5.8085171432279e-05 2 XRCC5|KU80-R-C 6.73966391083296e-10 0.259080623542243 3.75635679972835e-10 2 MAPK1|ERK2-R-NA 7.72359005225399e-07 0.241704672501161 2.90440881675617e-07 2 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9-R-V 0.00301315368296684 0.234489617802951 0.000807488572668563 2 CTNNA1|ALPHA-CATENIN-M-V 7.47480688003555e-08 0.227183837201229 3.28592958240823e-08 2 BIRC2 |CIAP-R-V 5.20856989464082e-09 0.205931280480549 2.54012533852067e-09 2 GAB2|GAB2-R-V 0.010308921257854 0.201815867112135 0.00261592166839157 2 NCOA3|AIB1-M-V 3.79694659053368e-10 0.1977048992267 2.19460999453237e-10 2 RB1|RB_PS807_S811-R-V 0.0094410689445891 0.182827178591362 0.0024153382708046 2 DVL3|DVL3-R-V 9.99428433961205e-09 0.179273838697317 4.79904661833799e-09 2 RAD50|RAD50-M-C 6.64438409090218e-12 0.179246987519451 4.82284049079992e-12 2 SMAD3|SMAD3-R-V 1.99832594011435e-11 0.177015029547351 1.32704329594547e-11 2 RAF1|C-RAF-R-V 9.2490028784185e-10 0.176240896218876 4.81127619396527e-10 2 PRKAA1|AMPK_ALPHA-R-C 1.43987533504352e-07 0.169441749100811 6.07309111500316e-08 2 CDKN1B|P27-R-V 0.000415653922685896 0.168560248785232 0.000120122607895946 2 NF2|NF2-R-C 2.27557708120562e-07 0.152577782864931 9.10570492530065e-08 2 PIK3CA |PI3K-P110-ALPHA-R-C 2.11967392019493e-07 0.15115686829293 8.70506640604547e-08 2 MAPK14|P38_MAPK-R-C 8.50404269814591e-06 0.147799392491909 2.98230495268675e-06 2 IRS1|IRS1-R-V 7.89013279547747e-06 0.144510573752152 2.79845459498749e-06 2 RPS6KA1|P90RSK_PT359_S363-R-C 0.000325385339652556 0.139591103591041 9.49141206267965e-05 2 RPS6|S6-R-NA 0.00655955983078648 0.135004637103597 0.00169202179024336 2 XRCC1|XRCC1-R-C 2.6842586289205e-10 0.129479603183153 1.67560241589796e-10 2 MAPT|TAU-M-C 0.0348469404912762 0.127861062116815 0.00817767105278365 2 STK11|LBK1-M-NA 5.72275678058971e-08 0.122794558446469 2.55166627064677e-08 2 YBX1|YB-1-R-V 0.00302695261548795 0.0977177035745366 0.000807488572668563 2 XIAP|XIAP-R-C 0.000242661647364932 0.078308552426678 7.28256595604453e-05 2 PXN|PAXILLIN-R-V 0.027251665267507 0.0771214084890866 0.00659355995959653 2 MAP2K1|MEK1_PS217_S221-R-V 0.0181029164715696 0.0740913362408816 0.00448429966456365 2 PEA15|PEA-15-R-V 0.0317051934164282 0.0672322694704748 0.00761208587221203 2 FOXO3|FOXO3A_PS318_S321-R-C 0.0341984686208662 -0.0441536964135677 0.00808629074096651 2 CDKN1B|P27_PT198-R-V 0.0319906180443702 -0.0616386014630801 0.00762198270874285 2 CDKN1A|P21-R-C 0.0375415627009482 -0.0618865926086164 0.00874428235218591 2 TGM2|TRANSGLUTAMINASE-M-V 0.0493584126566017 -0.069248521623263 0.0114115343102791 2 ITGA2|CD49B-M-V 0.0262491737205501 -0.0744297456468046 0.00640062364828823 2 JUN|C-JUN_PS73-R-C 0.0109642447165444 -0.0748575399285896 0.00275977489313716 2 YWHAE|14-3-3_EPSILON-M-C 5.8086884799311e-05 -0.0865790584445754 1.88852821278608e-05 2 XBP1|XBP1-G-C 0.0126780020970846 -0.0940847480688387 0.00316561015600462 2 VASP|VASP-R-C 0.00168370732952228 -0.100499217857893 0.000469207779473815 2 WWTR1|TAZ_PS89-R-C 0.00267230334896148 -0.102142874582003 0.000731640147986162 2 SRC|SRC-M-V 0.00399953196459673 -0.102290747068517 0.00104900808388771 2 BCL2L1|BCL-X-R-C 6.41743418830566e-05 -0.104344827493088 2.06493465846813e-05 2 EIF4EBP1|4E-BP1_PT170-R-V 4.9249977613047e-05 -0.107686499433751 1.63529010220222e-05 2 ANLN|ANLN-M-NA 9.81649918603387e-06 -0.110288729493766 3.404322928118e-06 2 SMAD4|SMAD4-M-C 4.14304626439123e-07 -0.114139601141357 1.59643554328831e-07 2 CHEK1|CHK1_PS345-R-C 6.24994010722553e-06 -0.114493095375808 2.2421942124846e-06 2 PCNA|PCNA-M-V 5.13936303605094e-05 -0.115819598118923 1.6885048624643e-05 2 RAB25|RAB25-R-C 0.00296257704505027 -0.116640159017933 0.000804059962693854 2 PARP1|PARP_CLEAVED-M-C 2.18362804536086e-05 -0.121651273826386 7.40811064991355e-06 2 MRE11A|MRE11-R-C 0.000644912018883158 -0.122544702950309 0.000184667554122164 2 STAT3|STAT3_PY705-R-V 0.00105090082635763 -0.123543846869003 0.000295498566946381 2 MYC|C-MYC-R-C 9.68529600024107e-05 -0.128388495742257 3.05347471309416e-05 2 RAF1|C-RAF_PS338-R-C 7.27751021402684e-10 -0.137091975736184 3.98496574277814e-10 2 SRC|SRC_PY416-R-C 0.00396750837296579 -0.148591735356447 0.00104900808388771 2 RPS6KB1|P70S6K_PT389-R-V 4.59481066676706e-06 -0.150100062200372 1.66757660515037e-06 2 YAP1|YAP-R-V 5.33611721206154e-07 -0.153019196764513 2.03108515783951e-07 2 FOXO3|FOXO3A-R-C 8.4908162779678e-08 -0.155115725632837 3.68072670125717e-08 2 PRKCA |PKC-ALPHA-M-V 6.34213628883949e-11 -0.156045897327046 4.12392689061881e-11 2 MET|C-MET-M-C 4.15150159519483e-12 -0.157914640986818 3.0851234230691e-12 2 YBX1|YB-1_PS102-R-V 0.000132000469585382 -0.160126144612582 4.07915987230716e-05 2 EIF4EBP1|4E-BP1_PS65-R-V 1.93256899994174e-08 -0.163803971590398 8.87039011744627e-09 2 CASP8|CASPASE-8-M-C 1.26522856122083e-10 -0.166880631202729 8.05915542382419e-11 2 MET|C-MET_PY1235-R-C 8.3403743774419e-07 -0.173970144376951 3.09900932939469e-07 2 TP53|P53-R-V 0.00588384983801373 -0.180360356335227 0.00153037181556929 2 SETD2|SETD2-R-NA 1.47839956685256e-09 -0.187910018487015 7.44246432308828e-10 2 BID|BID-R-C 6.31527052218979e-13 -0.190819949497339 4.92774915111571e-13 2 SNAI2|SNAIL-M-C 9.1240825470181e-10 -0.192160498543993 4.81127619396527e-10 2 RAD51|RAD51-M-C 4.52113136137839e-21 -0.193091542898796 7.33162656029951e-21 2 PRKCA |PKC-ALPHA_PS657-R-V 2.11354953535287e-06 -0.196114337725682 7.760865008884e-07 2 CHEK1|CHK1-R-V 1.42516167500723e-24 -0.202285189320151 5.56020459420033e-24 2 NOTCH1|NOTCH1-R-V 2.02557198793315e-17 -0.209767153145215 2.10738096048081e-17 2 BAK1|BAK-R-C 8.61041874226238e-14 -0.211965117570714 7.07224504874406e-14 2 SYK|SYK-M-V 0.00263884648027049 -0.222502145455578 0.000728873743756897 2 EGFR|EGFR_PY1173-R-C 3.63036152647634e-17 -0.22368294728182 3.65514665270557e-17 2 ERBB3|HER3_PY1298-R-V 1.61722471659601e-14 -0.225658056538635 1.36422269599137e-14 2 KRAS|K-RAS-M-C 9.66774492744698e-20 -0.225919358053942 1.17994746225837e-19 2 RB1|RB-M-V 2.01396583423421e-12 -0.229915285590683 1.53315077302384e-12 2 RPS6|S6_PS240_S244-R-V 3.91833923728888e-05 -0.232811237076483 1.31503014625309e-05 2 ERBB2|HER2_PY1248-R-V 0.000804192266231532 -0.232943514978673 0.000228183286748126 2 CHEK2|CHK2_PT68-R-C 0.000122283267636776 -0.244725659755653 3.81666163737883e-05 2 EIF4EBP1|4E-BP1_PT37-R-V 0.000323108273453742 -0.245902958755903 9.49141206267965e-05 2 CDC2|CDK1-R-V 3.97025314695072e-13 -0.250147893875255 3.17738774339615e-13 2 CDH2|N-CADHERIN-R-V 5.44256468457628e-20 -0.258302759737041 7.07797430848445e-20 2 CASP9|CASPASE-9_CLEAVEDD330-R-C 5.46455754079809e-21 -0.263432655741507 8.12180078906312e-21 2 EGFR|EGFR_PY992-R-V 3.36425837359411e-10 -0.284021712082842 1.98120810847018e-10 2 STMN1|STATHMIN-R-V 4.69800751581277e-21 -0.284759904016111 7.33162656029951e-21 2 RPS6|S6_PS235_S236-R-V 8.43777732150678e-05 -0.297595576683421 2.68731519939871e-05 2 CAV1|CAVEOLIN-1-R-V 0.0197014888164177 -0.309696008219483 0.00484185690021489 2 SRC|SRC_PY527-R-V 2.14878291280046e-07 -0.325764232515414 8.7100057347632e-08 2 PTK2|FAK-R-C 1.18345232472288e-08 -0.326337710908334 5.5965895326336e-09 2 CCNE1|CYCLIN_E1-M-V 9.4431371344146e-12 -0.335313621213268 6.6985413781747e-12 2 PTGS2|COX-2-R-C 2.46305502689387e-16 -0.336934363198693 2.32957554670276e-16 2 AKT1 AKT2 AKT3|AKT_PT308-R-V 1.85586589530392e-07 -0.356288266649377 7.72328305538993e-08 2 NOTCH3|NOTCH3-R-C 1.27352879068525e-11 -0.37314163783035 8.83309452705175e-12 2 CCNB1|CYCLIN_B1-R-V 0.00018456194128516 -0.380216135149716 5.64753072234225e-05 2 CDH3|P-CADHERIN-R-C 3.63570496103038e-23 -0.389121097161648 7.56508824020517e-23 2 EGFR|EGFR_PY1068-R-V 1.94968771580286e-09 -0.44572337792616 9.6591993712277e-10 2 AKT1 AKT2 AKT3|AKT_PS473-R-V 3.99848472902267e-07 -0.448923186790091 1.55999095050314e-07 2 LCK|LCK-R-V 9.8292276624709e-20 -0.498455590625585 1.17994746225837e-19 2 EGFR|EGFR-R-C 1.02499327920441e-22 -0.518173559966599 1.99948273939794e-22 2 CASP7|CASPASE-7_CLEAVEDD198-R-C 1.15475158353181e-20 -0.619636668207981 1.56703015829838e-20 2 ANXA1|ANNEXIN_I-R-V 2.2517009842164e-16 -0.648789910340514 2.19622769415651e-16 2 COL6A1|COLLAGEN_VI-R-V 1.3658742984188e-07 -0.651329800300254 5.83988771900561e-08 2 KIT|C-KIT-R-V 7.51306189358308e-19 -0.67794717777255 8.68500007996172e-19 2 HSPA1A|HSP70-R-C 8.35431228928243e-21 -0.940293667302754 1.18523549450542e-20 2 CAV1|CAVEOLIN-1-R-V 2.23381812463819e-36 2.03448373323033 1.16892088056069e-35 3 COL6A1|COLLAGEN_VI-R-V 2.00248809753368e-29 1.9525484827328 3.49289873462805e-29 3 HSPA1A|HSP70-R-C 7.04599689754515e-24 1.33935758945359 6.91323031774387e-24 3 ANXA1|ANNEXIN_I-R-V 3.71578287449925e-18 0.731101207583937 1.82288348942443e-18 3 CCND1|CYCLIN_D1-R-V 1.04964607843244e-25 0.634736963231649 1.37315702288549e-25 3 RB1|RB-M-V 5.56479019359762e-30 0.586107930847762 1.24798485762818e-29 3 PTK2|FAK-R-C 1.04803222443397e-13 0.57771048297918 3.73921571911086e-14 3 NOTCH3|NOTCH3-R-C 1.28830332744239e-12 0.544146002915899 4.21342678745149e-13 3 SRC|SRC_PY527-R-V 7.1149141545251e-16 0.530866145333525 2.93930483284143e-16 3 KIT|C-KIT-R-V 8.3414656834657e-11 0.51792790386636 2.56762001408077e-11 3 BAK1|BAK-R-C 3.52301829558616e-22 0.435300233357225 3.0725641170802e-22 3 EGFR|EGFR_PY1173-R-C 9.83209855133088e-25 0.434350475452024 1.18730263492169e-24 3 CDH2|N-CADHERIN-R-V 1.50762898478429e-24 0.433477808833361 1.69053825793544e-24 3 MAPK1 MAPK3|MAPK_PT202_Y204-R-V 0.000869919005431669 0.418997521814516 0.000124149419974951 3 KRAS|K-RAS-M-C 8.27028085975472e-22 0.389161796197169 6.491556236232e-22 3 CASP9|CASPASE-9_CLEAVEDD330-R-C 9.1337576163159e-22 0.387691236417627 6.82792510400053e-22 3 BID|BID-R-C 5.15784576645838e-19 0.379623621960171 2.89180417885631e-19 3 FN1|FIBRONECTIN-R-C 0.00434602911428607 0.37466480405711 0.000593271316965025 3 CASP8|CASPASE-8-M-C 6.30435456017594e-24 0.329647897349572 6.59793346877001e-24 3 LCK|LCK-R-V 2.14557621356511e-08 0.327059816866853 5.10338780129655e-09 3 PTCH1|PTCH-R-C 2.04676270913344e-10 0.326221970720293 6.17906427841043e-11 3 MET|C-MET-M-C 1.13506990962561e-20 0.324986327235681 7.42454647282676e-21 3 BCL2L1|BCL-X-R-C 3.56923116815119e-18 0.315699412977864 1.80747185682465e-18 3 ERBB3|HER3-M-C 1.11811391369501e-07 0.313648132656929 2.40448323086462e-08 3 SMAD4|SMAD4-M-C 2.1245265980591e-21 0.309053789958608 1.51599599056645e-21 3 ERBB3|HER3_PY1298-R-V 2.6481951865675e-17 0.296699558775922 1.18779230767134e-17 3 STAT3|STAT3_PY705-R-V 8.24627858506966e-08 0.280761068848502 1.79797673146318e-08 3 STMN1|STATHMIN-R-V 1.25619856294529e-09 0.275225049729427 3.28674191099359e-10 3 YWHAE|14-3-3_EPSILON-M-C 2.516330099626e-20 0.269630543745721 1.58010579109933e-20 3 RPS6KB1|P70S6K_PT389-R-V 2.41131793704737e-07 0.255134789395984 5.11542024477209e-08 3 YAP1|YAP-R-V 2.48598886390617e-10 0.251803112577107 7.36345895205927e-11 3 FOXO3|FOXO3A-R-C 2.02042085017344e-14 0.242763425010945 7.5518109977554e-15 3 EGFR|EGFR-R-C 1.77945619563125e-05 0.234408029447005 3.06976033472778e-06 3 AKT1 AKT2 AKT3|AKT_PS473-R-V 0.0143031768824842 0.219861155047482 0.00182551732476439 3 PTGS2|COX-2-R-C 2.38780527898577e-06 0.214245321564352 4.40999953008566e-07 3 PRKCA |PKC-ALPHA_PS657-R-V 1.03771949543105e-06 0.209851383293532 2.01119193054225e-07 3 SETD2|SETD2-R-NA 2.14241404822783e-06 0.198613650114467 4.00389502260475e-07 3 RAD51|RAD51-M-C 4.79574094442335e-10 0.188429259685978 1.3443930210149e-10 3 PRKCA |PKC-ALPHA-M-V 4.81342532537264e-08 0.171141342876481 1.09512503897317e-08 3 MAP2K1|MEK1-R-V 0.000208330099245208 0.169228618495968 3.30350818398348e-05 3 CHEK1|CHK1-R-V 3.71499639786068e-09 0.168276460317067 9.2571309756505e-10 3 EGFR|EGFR_PY992-R-V 0.00204247941907289 0.165176883734694 0.000288863900506609 3 YAP1|YAP_PS127-R-C 0.0100729058685388 0.164783414629938 0.00130685669191679 3 PARK7|DJ-1-R-C 0.00248571801567074 0.150717110875741 0.000345328146291496 3 PEA15|PEA-15-R-V 0.000161924319848147 0.150492388436965 2.59384826255734e-05 3 RAF1|C-RAF_PS338-R-C 1.3485423605732e-05 0.137682903254773 2.35223465779388e-06 3 MAPK14|P38_PT180_Y182-R-V 0.0219088822405775 0.136739889421412 0.00270816462569233 3 CDKN1B|P27-R-V 0.00408741055325576 0.126138489148041 0.00056286205436743 3 IRS1|IRS1-R-V 0.000126390459630639 0.121508685604098 2.06681507740596e-05 3 PCNA|PCNA-M-V 6.071021868603e-05 0.120041334376316 1.00322131967378e-05 3 CDKN1A|P21-R-C 0.000346208295558175 0.111896008625741 5.43495597834528e-05 3 SRC|SRC-M-V 0.0054589564635629 0.111835174886109 0.000726250065077191 3 BAX|BAX-R-V 0.0174458264563983 0.111464971698897 0.00219098848901946 3 ITGA2|CD49B-M-V 0.0197989913900131 0.0900773016287031 0.00246678377115887 3 NOTCH1|NOTCH1-R-V 0.00613058632096721 0.0876987599719388 0.000808748729356147 3 SMAD3|SMAD3-R-V 0.0050055559537505 0.0799862564200955 0.000671622163774029 3 XRCC1|XRCC1-R-C 0.000397037271278796 -0.0755211031742923 6.17118355959824e-05 3 PRDX1|PRDX1-R-NA 0.0142653037845689 -0.100143959110928 0.00182551732476439 3 EIF4EBP1|4E-BP1_PS65-R-V 0.000755655699662325 -0.108796010818137 0.00010883185343797 3 STK11|LBK1-M-NA 1.10470477514873e-05 -0.121562702924621 1.97070727593511e-06 3 PXN|PAXILLIN-R-V 0.0064086110307023 -0.125664550492182 0.00083838061462511 3 ERCC1|ERCC1-M-C 2.63371622562552e-05 -0.125935919455481 4.44574543966974e-06 3 MAP2K1|MEK1_PS217_S221-R-V 0.000420956905317773 -0.132538162211488 6.4788216853896e-05 3 PRKCD|PKC-DELTA_PS664-R-V 1.30053541295497e-05 -0.134461803392281 2.293985859846e-06 3 PIK3CA |PI3K-P110-ALPHA-R-C 3.88926933338298e-06 -0.151749328740701 7.09950597293116e-07 3 CDKN1B|P27_PT157-R-C 8.77469965472792e-06 -0.157629016205563 1.58333046593155e-06 3 SHC1|SHC_PY317-R-NA 0.0377871539669541 -0.166222772854674 0.00459846657204225 3 ERBB2|HER2_PY1248-R-V 0.0147413196155105 -0.166939722502963 0.00186626468574281 3 BECN1|BECLIN-G-V 0.000155539305653724 -0.174946887449144 2.51725366889664e-05 3 TGM2|TRANSGLUTAMINASE-M-V 4.49795214223864e-07 -0.175332356045919 9.05271375917453e-08 3 BCL2L11|BIM-R-V 0.000426084042730353 -0.177918413621379 6.49406462190683e-05 3 PRKAA1|AMPK_PT172-R-V 0.00213575984734765 -0.187279509711076 0.00029935943857402 3 AKT1S1|PRAS40_PT246-R-V 2.98743510902912e-08 -0.189766068994733 6.8968078882545e-09 3 IGF1R|IGF-1R-BETA-R-C 0.0402862910309539 -0.194384691498025 0.00486488405731032 3 WWTR1|TAZ_PS89-R-C 8.03236493287413e-09 -0.197085984331797 1.97025309493377e-09 3 RPS6|S6_PS235_S236-R-V 0.0232904501878615 -0.206173182962969 0.00285644900029556 3 ARAF|A-RAF_PS299-R-NA 4.49707363554036e-11 -0.222586812010533 1.44076277696618e-11 3 EIF4EBP1|4E-BP1-R-V 0.000537101722515451 -0.223570671974325 8.03018973924638e-05 3 RPS6|S6_PS240_S244-R-V 0.000696766520015646 -0.228425264866113 0.000101279623879383 3 PECAM1|CD31-M-V 0.00487130251490833 -0.234117102709513 0.000659243220632702 3 YBX1|YB-1-R-V 2.5744689552498e-07 -0.234618426469305 5.38871179341727e-08 3 PDK1|PDK1_PS241-R-V 7.84916760711033e-07 -0.235746590773535 1.55975028081968e-07 3 PTEN|PTEN-R-V 2.32931983775002e-05 -0.239238663043697 3.97465885361919e-06 3 RPS6KA1|P90RSK_PT359_S363-R-C 6.39713386971483e-11 -0.242287573792051 2.00850998751643e-11 3 DIABLO|SMAC-M-V 9.75474686248749e-07 -0.249231750501564 1.9141879490512e-07 3 NF2|NF2-R-C 1.33887028249574e-14 -0.256800555756419 5.12640845398745e-15 3 CHEK2|CHK2_PT68-R-C 0.000586990490932254 -0.265323352521396 8.6932818726253e-05 3 SRC|SRC_PY416-R-C 3.67805278091141e-05 -0.26559200124136 6.142549493296e-06 3 CDKN1B|P27_PT198-R-V 7.94873035976175e-13 -0.269518265710336 2.71267955455839e-13 3 INPP4B|INPP4B-G-C 0.000661589586977755 -0.270041669092742 9.70651755375051e-05 3 CCNE1|CYCLIN_E1-M-V 6.91690439204555e-10 -0.299942308021231 1.8404258390356e-10 3 EEF2|EEF2-R-V 2.08838818872705e-16 -0.305677271414006 9.10683123510324e-17 3 EEF2K|EEF2K-R-V 6.53192461042731e-08 -0.321058229605333 1.44424667303153e-08 3 NCOA3|AIB1-M-V 9.7417844317896e-21 -0.339352753578752 6.64919760942122e-21 3 CTNNA1|ALPHA-CATENIN-M-V 9.8318024247182e-09 -0.339923761664253 2.37453375064416e-09 3 RBM3|RBM3-M-NA 6.22334016975305e-08 -0.34397830306213 1.39567423488071e-08 3 RAF1|C-RAF-R-V 1.93723894893503e-18 -0.348689550606814 1.04868185863844e-18 3 MAPK1|ERK2-R-NA 4.31797532969391e-07 -0.352471852764813 8.80335048107871e-08 3 AKT1 AKT2 AKT3|AKT-R-V 3.9281684224559e-10 -0.374823860920754 1.12120744153606e-10 3 NFKB1|NF-KB-P65_PS536-R-C 2.3352432891075e-09 -0.383101146452107 5.91287916787805e-10 3 ATM|ATM-R-NA 1.30056054935026e-09 -0.385994138235681 3.34702766503239e-10 3 GATA3|GATA3-M-V 0.000523398805337823 -0.387613921303901 7.9005613278808e-05 3 ESR1|ER-ALPHA_PS118-R-V 2.57449991489435e-16 -0.389782722414006 1.09231958029895e-16 3 GAB2|GAB2-R-V 3.76245676920143e-10 -0.404592975487656 1.09379597182311e-10 3 DVL3|DVL3-R-V 1.3460655309004e-17 -0.40862046842207 6.215067462763e-18 3 BIRC2 |CIAP-R-V 3.50003290472612e-23 -0.422757973654131 3.23207750668905e-23 3 ACACA ACACB|ACC_PS79-R-V 3.69547097182282e-07 -0.430714592068795 7.63334275803996e-08 3 TP53|P53-R-V 1.10071305588001e-06 -0.435798205707291 2.10726341037284e-07 3 TSC2|TUBERIN-R-C 2.92287301805263e-15 -0.438139729577271 1.14711911782743e-15 3 STAT5A|STAT5-ALPHA-R-V 2.40764860861976e-08 -0.442737272322992 5.64126967245732e-09 3 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9-R-V 4.967756656982e-10 -0.456830102410303 1.36818246227756e-10 3 ACACA|ACC1-R-C 1.32094901036008e-06 -0.469444061949885 2.49842618184209e-07 3 SYK|SYK-M-V 5.85633639153446e-10 -0.530592832119486 1.58509969440333e-10 3 CHEK2|CHK2-M-C 4.63150944434148e-22 -0.544774243428489 3.82672729352482e-22 3 TP53BP1|53BP1-R-C 9.93615126036087e-20 -0.572406310235352 5.99933905809458e-20 3 RPS6KB1|P70S6K-R-V 8.16254212677357e-14 -0.577687097256666 2.97999503844723e-14 3 XRCC5|KU80-R-C 4.11851411086001e-30 -0.589527885482061 1.07757589751133e-29 3 KDR|VEGFR2-R-C 1.20578068759106e-12 -0.596861775268269 4.02743951366203e-13 3 RB1|RB_PS807_S811-R-V 2.59724280972564e-18 -0.621655385743828 1.35909513791154e-18 3 ERBB2|HER2-M-V 2.30324773181094e-13 -0.653566135572416 8.03501513730425e-14 3 MSH2|MSH2-M-C 2.36133601652627e-35 -0.682659901198403 9.26736697571778e-35 3 GSK3A GSK3B|GSK3-ALPHA-BETA-M-V 3.20107381972634e-26 -0.689410280581633 5.02521040565962e-26 3 BRAF|B-RAF-M-NA 1.12050755542093e-30 -0.724760651216754 3.51806084097296e-30 3 CLDN7|CLAUDIN-7-R-V 1.87773521781855e-15 -0.753924295218482 7.55837274603475e-16 3 RPS6|S6-R-NA 8.89580844336564e-30 -0.757250476083772 1.74563723276528e-29 3 CTNNB1|BETA-CATENIN-R-V 8.82231377455274e-26 -0.804638141079658 1.25906564991559e-25 3 FRAP1|MTOR-R-V 2.09274537078536e-39 -0.837181959262014 1.64264968662386e-38 3 MSH6|MSH6-R-C 2.63454451261294e-51 -0.865733804041968 4.13584354642837e-50 3 CCNB1|CYCLIN_B1-R-V 1.69319836141164e-19 -0.98939289007834 9.84470339895829e-20 3 CDH1|E-CADHERIN-R-V 1.04088338334951e-17 -1.11251879424333 4.95161302364706e-18 3