E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.07 0.164 -9999.0 0.0 -0.408 66.0 66.0 KLHL20 -0.025 0.09 0.251 1.0 -0.247 17.0 18.0 CYFIP2 -0.006 0.13 -9999.0 0.0 -0.42 45.0 45.0 Rac1/GDP -0.035 0.117 0.269 4.0 -0.264 60.0 64.0 ENAH -0.065 0.162 -9999.0 0.0 -0.347 110.0 110.0 AP1M1 0.035 0.021 -9999.0 0.0 -0.42 1.0 1.0 RAP1B 0.033 0.03 -9999.0 0.0 -0.42 2.0 2.0 RAP1A 0.031 0.045 -9999.0 0.0 -0.42 5.0 5.0 CTNNB1 0.025 0.067 -9999.0 0.0 -0.42 11.0 11.0 CDC42/GTP -0.013 0.083 -9999.0 0.0 -0.227 13.0 13.0 ABI1/Sra1/Nap1 -0.046 0.054 -9999.0 0.0 -0.157 40.0 40.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.03 0.104 -9999.0 0.0 -0.233 58.0 58.0 RAPGEF1 -0.073 0.154 0.236 2.0 -0.363 80.0 82.0 CTNND1 0.034 0.022 -9999.0 0.0 -0.42 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.074 0.183 -9999.0 0.0 -0.351 144.0 144.0 CRK -0.069 0.162 -9999.0 0.0 -0.386 81.0 81.0 E-cadherin/gamma catenin/alpha catenin 0.018 0.098 -9999.0 0.0 -0.26 49.0 49.0 alphaE/beta7 Integrin 0.044 0.039 -9999.0 0.0 -0.3 5.0 5.0 IQGAP1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.035 0.021 -9999.0 0.0 -0.42 1.0 1.0 Rap1/GTP/I-afadin 0.047 0.064 -9999.0 0.0 -0.229 22.0 22.0 DLG1 -0.082 0.177 -9999.0 0.0 -0.345 146.0 146.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.031 0.056 -9999.0 0.0 -0.153 60.0 60.0 MLLT4 0.02 0.078 -9999.0 0.0 -0.42 15.0 15.0 ARF6/GTP/NME1/Tiam1 0.056 0.045 -9999.0 0.0 -0.235 9.0 9.0 PI3K -0.036 0.074 -9999.0 0.0 -0.195 57.0 57.0 ARF6 0.033 0.029 -9999.0 0.0 -0.42 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.004 0.104 -9999.0 0.0 -0.305 48.0 48.0 TIAM1 0.028 0.057 -9999.0 0.0 -0.42 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.03 0.097 -9999.0 0.0 -0.219 57.0 57.0 AKT1 -0.024 0.053 0.173 3.0 -0.169 5.0 8.0 PIK3R1 0.019 0.08 -9999.0 0.0 -0.42 16.0 16.0 CDH1 -0.012 0.129 -9999.0 0.0 -0.42 45.0 45.0 RhoA/GDP -0.036 0.121 0.268 4.0 -0.27 63.0 67.0 actin cytoskeleton organization -0.017 0.068 0.175 2.0 -0.181 16.0 18.0 CDC42/GDP -0.033 0.116 0.268 4.0 -0.263 60.0 64.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.01 0.077 -9999.0 0.0 -0.216 56.0 56.0 ITGB7 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.033 0.104 -9999.0 0.0 -0.233 57.0 57.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.018 0.087 -9999.0 0.0 -0.215 56.0 56.0 mol:GDP -0.054 0.122 0.268 4.0 -0.298 64.0 68.0 CDC42/GTP/IQGAP1 0.045 0.014 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.042 -9999.0 0.0 -0.42 4.0 4.0 p120 catenin/RhoA/GDP -0.031 0.127 0.281 3.0 -0.277 63.0 66.0 RAC1/GTP/IQGAP1 0.046 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.049 0.033 -9999.0 0.0 -0.3 4.0 4.0 RHOA 0.026 0.061 -9999.0 0.0 -0.42 9.0 9.0 CDC42 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.035 0.021 -9999.0 0.0 -0.42 1.0 1.0 positive regulation of S phase of mitotic cell cycle -0.03 0.077 0.146 1.0 -0.185 80.0 81.0 NME1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.08 0.175 -9999.0 0.0 -0.405 83.0 83.0 regulation of cell-cell adhesion -0.018 0.069 -9999.0 0.0 -0.174 54.0 54.0 WASF2 -0.016 0.042 0.115 2.0 -0.108 12.0 14.0 Rap1/GTP -0.015 0.091 0.248 1.0 -0.251 13.0 14.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.036 0.104 -9999.0 0.0 -0.227 53.0 53.0 CCND1 -0.038 0.094 0.166 1.0 -0.229 80.0 81.0 VAV2 -0.068 0.183 -9999.0 0.0 -0.509 18.0 18.0 RAP1/GDP -0.02 0.101 0.264 1.0 -0.259 17.0 18.0 adherens junction assembly -0.078 0.171 -9999.0 0.0 -0.39 85.0 85.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.033 0.036 -9999.0 0.0 -0.42 3.0 3.0 regulation of heterotypic cell-cell adhesion 0.028 0.106 -9999.0 0.0 -0.219 62.0 62.0 E-cadherin/beta catenin -0.024 0.102 -9999.0 0.0 -0.286 63.0 63.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.081 0.175 -9999.0 0.0 -0.401 87.0 87.0 PIK3CA 0.033 0.022 -9999.0 0.0 -0.42 1.0 1.0 Rac1/GTP -0.076 0.128 -9999.0 0.0 -0.377 32.0 32.0 E-cadherin/beta catenin/alpha catenin 0.02 0.102 -9999.0 0.0 -0.254 56.0 56.0 ITGAE 0.028 0.046 -9999.0 0.0 -0.42 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.076 0.187 -9999.0 0.0 -0.359 143.0 143.0