rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	185	ACTB(2), ACTG1(1), ACTN2(4), ACTN3(1), ACTN4(4), AKT1(12), AKT2(1), AKT3(2), ARHGAP5(3), BAD(1), BRAF(2), CAPN2(2), CAV1(1), CCND1(1), CCND3(5), COL11A1(2), COL11A2(1), COL1A1(6), COL1A2(3), COL2A1(3), COL3A1(1), COL4A1(4), COL4A2(2), COL4A4(1), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A3(5), COL6A6(4), COMP(3), CRKL(1), EGF(2), EGFR(4), ELK1(2), ERBB2(4), FARP2(3), FIGF(1), FLNA(4), FLNB(7), FLNC(8), FLT1(2), FN1(3), GRB2(1), GRLF1(4), HGF(3), IGF1(1), IGF1R(1), ILK(2), ITGA1(3), ITGA10(1), ITGA11(4), ITGA2(2), ITGA2B(2), ITGA4(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGAV(3), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB8(1), JUN(1), KDR(2), LAMA1(6), LAMA2(7), LAMA3(6), LAMA4(4), LAMB1(3), LAMB2(3), LAMB3(4), LAMB4(6), LAMC1(2), LAMC2(1), LAMC3(1), MAP2K1(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MET(4), MYL7(1), MYLK(5), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PARVA(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PIP5K1C(3), PPP1R12A(1), PRKCG(1), PTEN(15), PTK2(1), PXN(1), RAF1(1), RAPGEF1(3), RELN(10), RHOA(2), ROCK1(1), ROCK2(2), SHC1(1), SHC3(1), SHC4(2), SOS1(3), SOS2(1), SPP1(1), THBS1(3), THBS3(1), THBS4(1), TLN1(7), TLN2(4), TNC(3), TNN(3), TNR(1), TNXB(3), VAV1(1), VAV3(1), VCL(3), VWF(6)	263403231	529	325	378	116	112	131	163	29	86	8	<1.00e-15	<5.98e-15
2	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AKT1(12), AKT2(1), AKT3(2), APAF1(1), ATM(9), BAD(1), BID(4), CAPN1(3), CAPN2(2), CASP6(1), CASP8(2), CSF2RB(2), DFFB(2), FAS(1), FASLG(1), IKBKB(2), IL1A(1), IL1R1(1), IL1RAP(2), IL3RA(1), IRAK1(1), IRAK2(2), IRAK3(1), IRAK4(2), NFKB1(1), NFKB2(4), NTRK1(1), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PPP3CA(3), PPP3CB(2), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RELA(1), RIPK1(3), TNFRSF10D(1), TNFRSF1A(1), TP53(142)	59436624	408	310	210	20	82	90	118	15	100	3	<1.00e-15	<5.98e-15
3	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	231	ACVR1B(4), ACVR1C(1), AKT1(12), AKT2(1), AKT3(2), ARRB1(1), ATF4(1), BDNF(1), BRAF(2), CACNA1A(5), CACNA1B(1), CACNA1C(4), CACNA1D(4), CACNA1E(8), CACNA1F(6), CACNA1G(5), CACNA1I(2), CACNA1S(1), CACNA2D1(4), CACNA2D2(2), CACNA2D3(5), CACNA2D4(1), CACNB1(1), CACNB2(2), CACNG2(1), CACNG3(2), CACNG4(1), CACNG6(1), CD14(1), CDC25B(3), CRKL(1), DUSP10(1), DUSP16(3), DUSP6(1), DUSP7(1), DUSP9(1), EGF(2), EGFR(4), ELK1(2), FAS(1), FASLG(1), FGF11(1), FGF13(2), FGF18(2), FGF23(1), FGF3(1), FGF5(1), FGF6(1), FGF7(2), FGFR2(2), FGFR4(3), FLNA(4), FLNB(7), FLNC(8), GRB2(1), IKBKB(2), IL1A(1), IL1R1(1), IL1R2(3), JUN(1), KRAS(1), MAP2K1(1), MAP2K3(1), MAP2K4(18), MAP2K5(1), MAP3K1(53), MAP3K10(4), MAP3K12(2), MAP3K13(3), MAP3K4(3), MAP3K5(1), MAP3K6(1), MAP3K8(2), MAP4K1(1), MAP4K4(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPKAPK3(1), MAPT(1), MAX(1), MEF2C(2), MOS(2), MYC(1), NF1(13), NFATC4(3), NFKB1(1), NFKB2(4), NLK(1), NR4A1(1), NTRK1(1), NTRK2(1), PAK1(2), PAK2(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PPP3CA(3), PPP3CB(2), PRKACA(1), PRKCG(1), PTPN5(2), PTPN7(1), PTPRR(1), RAF1(1), RAPGEF2(1), RASA1(2), RASA2(1), RASGRF1(3), RASGRP2(2), RASGRP4(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KA6(3), SOS1(3), SOS2(1), SRF(1), STK3(1), STK4(1), TAOK1(2), TAOK2(1), TGFB3(1), TGFBR1(2), TNFRSF1A(1), TP53(142), TRAF6(1), ZAK(1)	202419750	491	304	428	74	74	134	70	28	152	33	<1.00e-15	<5.98e-15
4	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	193	ACTN2(4), ACTN3(1), ACTN4(4), APC(3), ARAF(1), ARHGEF1(5), ARHGEF12(2), ARHGEF4(2), ARHGEF6(1), ARHGEF7(2), ARPC1A(1), ARPC1B(1), ARPC2(2), BAIAP2(1), BDKRB1(2), BRAF(2), C3orf10(1), CD14(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CRKL(1), CYFIP2(2), DIAPH3(1), EGF(2), EGFR(4), EZR(2), F2(2), F2R(2), FGD3(2), FGF11(1), FGF13(2), FGF18(2), FGF23(1), FGF3(1), FGF5(1), FGF6(1), FGF7(2), FGFR2(2), FGFR4(3), FN1(3), GIT1(1), GRLF1(4), GSN(1), IQGAP1(1), IQGAP2(2), IQGAP3(3), ITGA1(3), ITGA10(1), ITGA11(4), ITGA2(2), ITGA2B(2), ITGA4(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGAD(1), ITGAL(1), ITGAM(1), ITGAV(3), ITGAX(2), ITGB1(2), ITGB2(3), ITGB3(2), ITGB4(4), ITGB5(2), ITGB8(1), KRAS(1), LIMK1(3), LIMK2(1), MAP2K1(1), MAPK1(1), MAPK3(1), MOS(2), MSN(1), MYH10(4), MYH14(5), MYH9(5), MYL7(1), MYLK(5), NCKAP1(3), NCKAP1L(3), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PIP4K2A(1), PIP4K2C(5), PIP5K1A(1), PIP5K1C(3), PPP1R12A(1), PTK2(1), PXN(1), RAF1(1), RDX(1), RHOA(2), ROCK1(1), ROCK2(2), SCIN(2), SOS1(3), SOS2(1), SSH1(1), SSH2(1), SSH3(2), TIAM1(1), TIAM2(4), VAV1(1), VAV3(1), VCL(3), WAS(1), WASF1(1), WASL(1)	197302092	416	288	275	90	103	88	140	24	61	0	<1.00e-15	<5.98e-15
5	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	15	ABL1(2), E2F1(2), MDM2(1), MYC(1), PIK3CA(168), PIK3R1(14), POLR1A(1), POLR1B(2), POLR1C(2), POLR1D(1), RB1(9), TP53(142)	14867268	345	285	157	11	72	53	112	11	97	0	<1.00e-15	<5.98e-15
6	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	123	ACACA(1), ACACB(8), AKT1(12), AKT2(1), AKT3(2), ARAF(1), BAD(1), BRAF(2), CBLB(7), CBLC(3), CRKL(1), ELK1(2), G6PC2(1), GCK(2), GRB2(1), GYS1(5), GYS2(1), IKBKB(2), INPP5D(2), INSR(2), IRS1(1), IRS4(1), KRAS(1), LIPE(2), MAP2K1(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), PCK1(1), PCK2(1), PDE3A(6), PDE3B(1), PFKM(3), PFKP(2), PHKA2(4), PHKB(2), PHKG2(1), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PPARGC1A(1), PPP1R3A(6), PPP1R3B(1), PRKAA2(2), PRKAB1(1), PRKACA(1), PRKAG2(1), PRKAG3(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCI(1), PRKCZ(1), PTPRF(3), PYGB(3), PYGL(1), PYGM(2), RAF1(1), RAPGEF1(3), RPS6(1), RPS6KB2(3), SHC1(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS4(1), SORBS1(4), SOS1(3), SOS2(1), TRIP10(3), TSC1(2), TSC2(2)	107951961	335	261	185	44	86	81	112	14	42	0	<1.00e-15	<5.98e-15
7	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CDS1(2), DGKA(3), DGKD(1), DGKE(1), DGKG(4), DGKH(1), DGKI(5), IMPA1(1), INPP4A(2), INPP4B(3), INPP5B(4), INPP5D(2), INPPL1(1), ITGB1BP3(1), ITPK1(1), ITPKB(7), ITPR1(7), ITPR3(4), OCRL(3), PI4KA(3), PI4KB(1), PIK3C2A(2), PIK3C2B(2), PIK3C2G(1), PIK3C3(2), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PIP4K2A(1), PIP4K2C(5), PIP5K1A(1), PIP5K1C(3), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(2), PLCE1(5), PLCG1(4), PLCG2(2), PLCZ1(1), PRKCG(1), PTEN(15), SYNJ2(1)	89527581	306	254	165	39	77	50	113	14	50	2	<1.00e-15	<5.98e-15
8	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	148	AKT1(12), AKT2(1), AKT3(2), CBLB(7), CBLC(3), CCND1(1), CCND3(5), CNTFR(1), CREBBP(2), CSF2RA(1), CSF2RB(2), CSF3R(2), EP300(3), EPOR(1), GH2(1), GHR(2), GRB2(1), IFNA10(1), IFNA14(1), IFNA2(2), IFNA4(1), IFNAR2(1), IFNB1(1), IFNK(1), IL10RA(1), IL10RB(3), IL11RA(1), IL12A(1), IL12B(1), IL12RB1(2), IL13RA1(1), IL13RA2(2), IL15(1), IL2(1), IL21(1), IL21R(1), IL22(1), IL22RA1(1), IL22RA2(1), IL23R(3), IL28B(3), IL28RA(1), IL2RG(1), IL3RA(1), IL5RA(1), IL6(2), IL6R(1), IL6ST(3), IRF9(2), JAK1(1), JAK2(2), JAK3(1), LEPR(3), LIF(3), LIFR(4), MYC(1), OSMR(3), PIAS2(1), PIAS4(2), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PRLR(1), SOCS4(1), SOCS5(1), SOS1(3), SOS2(1), SPRED1(2), SPRED2(1), STAM(1), STAM2(1), STAT1(1), STAT2(1), STAT3(1), STAT4(5), STAT5B(4), TPO(6), TSLP(1), TYK2(3)	106057302	335	251	183	40	87	64	116	18	47	3	<1.00e-15	<5.98e-15
9	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(2), ABL2(2), AKT1(12), AKT2(1), AKT3(2), ARAF(1), BAD(1), BRAF(2), BTC(1), CAMK2A(1), CAMK2D(3), CBLB(7), CBLC(3), CDKN1B(5), CRKL(1), EGF(2), EGFR(4), ELK1(2), ERBB2(4), ERBB3(8), ERBB4(4), GAB1(1), GRB2(1), JUN(1), KRAS(1), MAP2K1(1), MAP2K4(18), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MYC(1), NRG3(1), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG1(4), PLCG2(2), PRKCG(1), PTK2(1), RAF1(1), RPS6KB2(3), SHC1(1), SHC3(1), SHC4(2), SOS1(3), SOS2(1), STAT5B(4), TGFA(1)	72661719	316	246	164	29	72	58	116	19	51	0	<1.00e-15	<5.98e-15
10	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	74	ABL1(2), AKT1(12), AKT2(1), AKT3(2), ARHGEF6(1), ARHGEF7(2), BRAF(2), CAV1(1), CSE1L(2), EPHB2(1), GRB2(1), GRB7(3), GRLF1(4), ILK(2), ITGA1(3), ITGA10(1), ITGA11(4), ITGA2(2), ITGA4(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGB3BP(1), MAP2K4(18), MAP3K11(1), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1), MYLK(5), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PIK3CA(168), PIK3CB(3), PLCG1(4), PLCG2(2), PTEN(15), PTK2(1), RAF1(1), RHO(2), ROCK1(1), ROCK2(2), SHC1(1), SOS1(3), SOS2(1), TERF2IP(2), TLN1(7), TLN2(4), WAS(1)	87730266	310	241	160	37	74	59	111	10	54	2	<1.00e-15	<5.98e-15
11	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	93	AKT1(12), AKT2(1), AKT3(2), CASP8(2), CD14(1), CD40(1), CD86(1), IFNA10(1), IFNA14(1), IFNA2(2), IFNA4(1), IFNAR2(1), IFNB1(1), IKBKB(2), IKBKE(1), IL12A(1), IL12B(1), IL6(2), IRAK1(1), IRAK4(2), IRF3(1), JUN(1), LBP(1), MAP2K1(1), MAP2K3(1), MAP2K4(18), MAP3K8(2), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(1), NFKB2(4), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), RELA(1), RIPK1(3), SPP1(1), STAT1(1), TICAM1(2), TIRAP(2), TLR1(1), TLR2(1), TLR3(1), TLR4(7), TLR5(1), TLR7(3), TLR8(2), TRAF6(1)	63743082	288	235	136	22	71	54	104	7	49	3	<1.00e-15	<5.98e-15
12	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	79	ACVR1(1), ACVR1B(4), AKT1(12), BMPR2(2), CDKL1(2), CDKL2(1), CDS1(2), CLK1(1), CLK4(1), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKA(3), DGKD(1), DGKE(1), DGKG(4), DGKH(1), IMPA1(1), INPP4A(2), INPP4B(3), INPPL1(1), ITPKB(7), MAP3K10(4), MOS(2), NEK1(1), NEK3(2), OCRL(3), PIK3C2A(2), PIK3C2B(2), PIK3C2G(1), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIM2(1), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCG1(4), PLCG2(2), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), PRKD1(1), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), TGFBR1(2)	82032093	283	234	132	33	74	56	112	13	28	0	<1.00e-15	<5.98e-15
13	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	ARAF(1), BID(4), BRAF(2), CD244(1), FAS(1), FASLG(1), GRB2(1), HLA-A(4), HLA-C(3), HLA-E(2), HLA-G(2), IFNA10(1), IFNA14(1), IFNA2(2), IFNA4(1), IFNAR2(1), IFNB1(1), ITGAL(1), ITGB2(3), KIR2DL3(1), KIR2DL4(1), KIR3DL2(4), KLRC1(3), KLRC2(1), KLRC3(1), KLRK1(2), KRAS(1), LAT(1), LCP2(1), MAP2K1(1), MAPK1(1), MAPK3(1), NCR2(1), NFAT5(1), NFATC3(3), NFATC4(3), PAK1(2), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG1(4), PLCG2(2), PPP3CA(3), PPP3CB(2), PRF1(2), PRKCG(1), PTK2B(3), RAF1(1), SH3BP2(1), SHC1(1), SHC3(1), SHC4(2), SOS1(3), SOS2(1), TNFRSF10D(1), ULBP3(2), VAV1(1), VAV3(1), ZAP70(1)	80572947	283	228	142	36	72	51	116	7	37	0	<1.00e-15	<5.98e-15
14	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	103	ACTN2(4), ACTN3(1), ACTN4(4), ARHGAP5(3), CD99(2), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN6(1), CTNNA1(1), CTNNA2(2), CTNNA3(2), CTNND1(1), CYBB(1), ESAM(2), EZR(2), F11R(1), GNAI1(1), GNAI2(1), GRLF1(4), ITGA4(1), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(3), ITK(3), MAPK14(1), MLLT4(7), MMP9(1), MSN(1), MYL7(1), NCF2(2), NOX1(1), NOX3(1), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG1(4), PLCG2(2), PRKCG(1), PTK2(1), PTK2B(3), PXN(1), RAPGEF3(2), RAPGEF4(2), RASSF5(1), RHOA(2), ROCK1(1), ROCK2(2), SIPA1(1), TXK(1), VAV1(1), VAV3(1), VCAM1(2), VCL(3)	88595208	282	228	142	42	77	46	107	7	45	0	<1.00e-15	<5.98e-15
15	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	69	AKT1(12), AKT2(1), AKT3(2), BTK(2), FCER1A(2), GAB2(1), GRB2(1), INPP5D(2), KRAS(1), LAT(1), LCP2(1), LYN(3), MAP2K1(1), MAP2K3(1), MAP2K4(18), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), PDK1(1), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLCG1(4), PLCG2(2), RAF1(1), SOS1(3), SOS2(1), VAV1(1), VAV3(1)	49987665	270	227	117	16	68	56	102	7	37	0	<1.00e-15	<5.98e-15
16	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(2), ELK1(2), FCER1A(2), GRB2(1), JUN(1), LYN(3), MAP2K1(1), MAP2K4(18), MAP3K1(53), MAPK1(1), MAPK3(1), MAPK8(2), NFATC3(3), NFATC4(3), PAK2(1), PIK3CA(168), PIK3R1(14), PLA2G4A(6), PLCG1(4), PPP3CA(3), PPP3CB(2), RAF1(1), SHC1(1), SOS1(3), VAV1(1)	30805320	297	226	154	8	66	36	107	3	57	28	<1.00e-15	<5.98e-15
17	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	44	IMPA1(1), INPP4A(2), INPP4B(3), INPP5B(4), INPPL1(1), IPMK(1), ITGB1BP3(1), ITPK1(1), ITPKB(7), MINPP1(1), OCRL(3), PI4KA(3), PI4KB(1), PIK3C3(2), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIP4K2A(1), PIP4K2C(5), PIP5K1A(1), PIP5K1C(3), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(2), PLCE1(5), PLCG1(4), PLCG2(2), PLCZ1(1), PTEN(15), SYNJ2(1)	51750504	257	222	118	23	69	39	105	8	34	2	<1.00e-15	<5.98e-15
18	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3E(1), CD3G(1), ELK1(2), GRB2(1), JUN(1), LAT(1), MAP2K1(1), MAP2K4(18), MAP3K1(53), MAPK3(1), MAPK8(2), NFATC3(3), NFATC4(3), NFKB1(1), PIK3CA(168), PIK3R1(14), PLCG1(4), PPP3CA(3), PPP3CB(2), PTPN7(1), RAF1(1), RASA1(2), RELA(1), SHC1(1), SOS1(3), VAV1(1), ZAP70(1)	34815183	291	222	149	11	64	32	106	2	59	28	<1.00e-15	<5.98e-15
19	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(12), BCR(1), CRKL(1), GRB2(1), JAK2(2), JUN(1), MAP2K1(1), MAP2K4(18), MAP3K1(53), MAPK3(1), MAPK8(2), MYC(1), PIK3CA(168), PIK3R1(14), RAF1(1), SOS1(3), STAT1(1), STAT5B(4)	20230821	285	220	133	8	60	39	97	3	58	28	<1.00e-15	<5.98e-15
20	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT1(12), AKT2(1), AKT3(2), ARHGEF11(1), BTK(2), GDI1(3), INPPL1(1), ITPR1(7), ITPR3(4), LIMK1(3), MYLK(5), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PDK1(1), PIK3CA(168), PIK3CG(2), PIK3R1(14), PITX2(1), PTEN(15), RHO(2), ROCK1(1), ROCK2(2), RPS4X(1), WASF1(1), WASL(1)	52170300	255	220	105	25	64	41	103	7	38	2	<1.00e-15	<5.98e-15
21	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(2), ATM(9), CCNA2(2), CCNB1(2), CCNB3(3), CCND3(5), CDC25B(3), CDC7(1), CDH1(31), CDK2(1), CHEK2(2), DTX4(1), E2F1(2), E2F3(1), E2F4(2), EP300(3), ESPL1(6), HDAC1(2), HDAC2(2), HDAC3(1), HDAC6(2), HDAC8(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(1), ORC2L(1), ORC3L(1), PLK1(1), PRKDC(7), PTPRA(1), RB1(9), RBL1(1), SMAD4(1), TBC1D8(1), TP53(142)	82755075	260	219	209	22	28	57	31	14	127	3	<1.00e-15	<5.98e-15
22	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(12), AKT2(1), AKT3(2), CARD11(2), CBLB(7), CBLC(3), CD3E(1), CD3G(1), CD4(1), CD40LG(1), CD8A(1), GRB2(1), IKBKB(2), IL2(1), ITK(3), JUN(1), KRAS(1), LAT(1), LCP2(1), MALT1(1), MAP3K8(2), NFAT5(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKB2(4), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PDK1(1), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG1(4), PPP3CA(3), PPP3CB(2), PRKCQ(2), PTPRC(1), RHOA(2), SOS1(3), SOS2(1), TEC(1), VAV1(1), VAV3(1), ZAP70(1)	72247500	274	219	124	29	69	54	111	9	28	3	<1.00e-15	<5.98e-15
23	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(2), EGFR(4), ELK1(2), GRB2(1), JAK1(1), JUN(1), MAP2K1(1), MAP2K4(18), MAP3K1(53), MAPK3(1), MAPK8(2), PIK3CA(168), PIK3R1(14), PLCG1(4), RAF1(1), RASA1(2), SHC1(1), SOS1(3), SRF(1), STAT1(1), STAT3(1)	27825174	283	218	141	7	63	29	98	7	58	28	<1.00e-15	<5.98e-15
24	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(1), ELK1(2), GRB2(1), JAK1(1), JUN(1), MAP2K1(1), MAP2K4(18), MAP3K1(53), MAPK3(1), MAPK8(2), PDGFRA(3), PIK3CA(168), PIK3R1(14), PLCG1(4), RAF1(1), RASA1(2), SHC1(1), SOS1(3), SRF(1), STAT1(1), STAT3(1)	25663326	280	215	138	7	64	28	99	3	58	28	<1.00e-15	<5.98e-15
25	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(12), AKT2(1), AKT3(2), CAP1(2), F2RL2(1), GRB2(1), GSK3A(1), INPPL1(1), IRS1(1), IRS4(1), MAPK1(1), MAPK3(1), PARD3(3), PDK1(1), PIK3CA(168), PIK3R1(14), PTEN(15), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SLC2A4(1), SORBS1(4), SOS1(3), SOS2(1), YWHAB(1)	42707145	243	215	93	18	61	41	102	4	33	2	<1.00e-15	<5.98e-15
26	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(12), AKT2(1), AKT3(2), BAD(1), CDK2(1), CDKN1B(5), CREB3(1), EBP(1), ERBB4(4), F2RL2(1), GAB1(1), GRB2(1), GSK3A(1), IGF1(1), INPPL1(1), IRS1(1), IRS4(1), MET(4), MYC(1), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PARD3(3), PDK1(1), PIK3CA(168), PREX1(5), PTEN(15), PTK2(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SLC2A4(1), SOS1(3), SOS2(1), TSC1(2), TSC2(2), YWHAB(1)	54199314	255	215	105	17	64	49	102	5	30	5	<1.00e-15	<5.98e-15
27	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	64	AKT1(12), AKT2(1), AKT3(2), BAD(1), KDR(2), KRAS(1), MAP2K1(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPKAPK3(1), NFAT5(1), NFATC3(3), NFATC4(3), NOS3(2), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLCG1(4), PLCG2(2), PPP3CA(3), PPP3CB(2), PRKCG(1), PTGS2(1), PTK2(1), PXN(1), RAF1(1), SH2D2A(2), SPHK2(2)	48350562	254	214	102	20	64	51	106	8	25	0	<1.00e-15	<5.98e-15
28	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(12), APC(3), AR(3), BRAF(2), CCL13(1), EGFR(4), GNAI1(1), GNAQ(1), ITPKB(7), ITPR1(7), ITPR3(4), KCNJ3(1), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(4), PIK3CA(168), PIK3R1(14), PITX2(1), PTX3(1), RAF1(1)	39066885	238	214	88	19	63	43	96	9	27	0	<1.00e-15	<5.98e-15
29	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	46	ACOX1(2), CD36(1), CITED2(1), CREBBP(2), EHHADH(2), EP300(3), FABP1(1), HSD17B4(3), JUN(1), LPL(1), MAPK1(1), MAPK3(1), MYC(1), NCOA1(1), NCOR1(16), NCOR2(3), NR0B2(2), PIK3CA(168), PIK3R1(14), PPARA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTGS2(1), RB1(9), RELA(1), SP1(1), STAT5B(4)	43690218	244	213	103	16	61	30	99	6	46	2	<1.00e-15	<5.98e-15
30	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(12), DLD(1), DUSP10(1), GAB1(1), GCK(2), IL1R1(1), JUN(1), MAP2K4(18), MAP2K5(1), MAP3K1(53), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(3), MAP3K4(3), MAP3K5(1), MAP3K9(1), MAPK10(1), MAPK8(2), MYEF2(1), NFATC3(3), PAPPA(4), SHC1(1), TP53(142), TRAF6(1), ZAK(1)	36173943	262	213	202	11	28	57	29	7	113	28	<1.00e-15	<5.98e-15
31	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(12), AKT2(1), AKT3(2), BAD(1), BCR(1), BLNK(1), BTK(2), CD19(1), CD22(1), CR2(2), GRB2(1), GSK3A(1), INPP5D(2), ITPR1(7), ITPR3(4), LYN(3), MAP4K1(1), MAPK1(1), MAPK3(1), NR0B2(2), PDK1(1), PIK3CA(168), PIK3R1(14), PLCG2(2), PPP3CA(3), PPP3CB(2), PTPRC(1), RAF1(1), SHC1(1), SOS1(3), SOS2(1), VAV1(1)	53513850	245	212	95	19	62	52	104	4	23	0	<1.00e-15	<5.98e-15
32	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(12), MAP2K1(1), MAP2K3(1), MAP3K1(53), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(1), PIK3CA(168), PIK3R1(14), RB1(9), RELA(1), SP1(1)	14376492	264	211	113	8	56	37	93	2	48	28	<1.00e-15	<5.98e-15
33	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(12), AKT2(1), AKT3(2), BLNK(1), BTK(2), CARD11(2), CD19(1), CD22(1), CD79A(1), CR2(2), IFITM1(1), IKBKB(2), INPP5D(2), JUN(1), KRAS(1), LYN(3), MALT1(1), NFAT5(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKB2(4), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG2(2), PPP3CA(3), PPP3CB(2), VAV1(1), VAV3(1)	52241787	245	211	95	23	61	49	102	5	25	3	<1.00e-15	<5.98e-15
34	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(12), AKT2(1), AKT3(2), BAD(1), BCR(1), BLNK(1), BTK(2), CD19(1), EPHB2(1), GRB2(1), ITPKB(7), LYN(3), MAP2K1(1), MAPK1(1), NFAT5(1), NFKB1(1), NFKB2(4), PI3(1), PIK3CA(168), PIK3R1(14), PLCG2(2), RAF1(1), SERPINA4(3), SHC1(1), SOS1(3), SOS2(1), VAV1(1)	36893883	236	210	86	10	60	48	96	5	24	3	<1.00e-15	<5.98e-15
35	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	54	ALG2(1), BAK1(1), BFAR(1), BTK(2), CAD(7), CASP8(2), EGFR(4), EPHB2(1), IL1A(1), MAP2K4(18), MAP3K1(53), MAP3K5(1), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1), MET(4), NFAT5(1), NFKB1(1), NFKB2(4), NR0B2(2), PTPN13(4), RIPK1(3), ROCK1(1), TP53(142), TUFM(2)	51259728	261	210	211	15	29	50	25	12	111	34	<1.00e-15	<5.98e-15
36	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	APAF1(1), BAD(1), BAK1(1), BCL2L11(1), BID(4), CASP1(1), CASP2(2), CASP6(1), CASP8(2), DFFB(2), FAS(1), FASLG(1), IKBKB(2), IRF3(1), IRF6(2), JUN(1), MAP2K4(18), MAP3K1(53), MAPK10(1), MDM2(1), MYC(1), NFKB1(1), PLEKHG5(3), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TNFRSF21(2), TP53(142)	40308528	253	209	203	13	27	51	26	9	112	28	<1.00e-15	<5.98e-15
37	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(12), AKT2(1), AKT3(2), BCR(1), BTK(2), CD19(1), GAB1(1), ITPR1(7), ITPR3(4), LYN(3), NR0B2(2), PDK1(1), PIK3CA(168), PITX2(1), PLCG2(2), PREX1(5), PTEN(15), PTPRC(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), TEC(1), VAV1(1)	41165358	236	208	87	13	61	44	100	4	25	2	<1.00e-15	<5.98e-15
38	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	AKT1(12), DGKA(3), ITPKB(7), ITPR1(7), ITPR3(4), MAP2K1(1), MAPK1(1), MAPK3(1), PAK1(2), PDE3A(6), PDE3B(1), PI3(1), PIK3C2G(1), PIK3CA(168), PIK3R1(14), RIPK3(1), RPS4X(1)	36446709	231	208	81	18	61	41	96	9	24	0	<1.00e-15	<5.98e-15
39	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	AGT(3), AKT1(12), CALR(1), CAMK1(1), CAMK1G(1), CREBBP(2), EDN1(2), F2(2), IGF1(1), LIF(3), MAP2K1(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MEF2C(2), MYH2(1), NFATC3(3), NFATC4(3), NPPA(1), PIK3CA(168), PIK3R1(14), PPP3CA(3), PPP3CB(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAF1(1)	36006126	235	207	85	17	61	43	102	7	22	0	<1.00e-15	<5.98e-15
40	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5(1), CHN1(1), LIMK1(3), MAP3K1(53), MYLK(5), NCF2(2), PAK1(2), PDGFRA(3), PIK3CA(168), PIK3R1(14), PLD1(1), TRIO(2), VAV1(1), WASF1(1)	26292006	257	206	116	17	62	28	95	5	39	28	<1.00e-15	<5.98e-15
41	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	37	AKT1(12), BRAF(2), CREB3(1), CREBBP(2), CRKL(1), EGR1(1), EGR2(1), EGR3(3), ELK1(2), GNAQ(1), JUN(1), MAP2K4(18), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), NTRK1(1), OPN1LW(1), PIK3C2G(1), PIK3CA(168), PIK3R1(14), RPS6KA3(2), SHC1(1), TERF2IP(2)	34096257	241	206	90	11	64	37	99	4	37	0	<1.00e-15	<5.98e-15
42	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	AKT1(12), AKT2(1), AKT3(2), BRAF(2), EIF4B(1), FIGF(1), IGF1(1), MAPK1(1), MAPK3(1), PIK3CA(168), PIK3CB(3), PIK3CG(2), PIK3R1(14), PIK3R3(1), PRKAA2(2), RICTOR(3), RPS6(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3), RPS6KB2(3), TSC1(2), TSC2(2)	34767018	231	205	81	17	62	43	98	6	22	0	<1.00e-15	<5.98e-15
43	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	CRKL(1), ELK1(2), GAB1(1), GRB2(1), HGF(3), ITGA1(3), ITGB1(2), JUN(1), MAP2K1(1), MAP4K1(1), MAPK1(1), MAPK3(1), MAPK8(2), MET(4), PAK1(2), PIK3CA(168), PIK3R1(14), PTEN(15), PTK2(1), PTK2B(3), PXN(1), RAF1(1), RASA1(2), SOS1(3), STAT3(1)	32792760	235	205	95	9	59	33	103	4	31	5	<1.00e-15	<5.98e-15
44	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	104	ABL1(2), ANAPC1(1), ANAPC5(4), ANAPC7(1), ATM(9), ATR(2), CCNA2(2), CCNB1(2), CCNB3(3), CCND1(1), CCND3(5), CDC23(1), CDC25B(3), CDC27(1), CDC7(1), CDK2(1), CDK6(1), CDK7(1), CDKN1B(5), CHEK2(2), CREBBP(2), CUL1(1), E2F1(2), E2F3(1), EP300(3), ESPL1(6), HDAC1(2), HDAC2(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(1), ORC2L(1), ORC3L(1), PLK1(1), PRKDC(7), RB1(9), RBL1(1), RBL2(1), SMAD2(3), SMAD3(2), SMAD4(1), SMC1A(2), SMC1B(2), TGFB3(1), TP53(142), YWHAB(1)	100298796	252	204	202	21	30	61	36	16	106	3	<1.00e-15	<5.98e-15
45	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(12), EIF4A2(3), EIF4G2(1), EIF4G3(2), GHR(2), IRS1(1), MAPK1(1), MAPK14(1), MAPK3(1), PABPC1(3), PDK2(1), PIK3CA(168), PIK3R1(14), PTEN(15)	21027825	225	203	75	12	56	37	95	4	31	2	<1.00e-15	<5.98e-15
46	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	135	APC(3), AXIN1(1), CAMK2A(1), CAMK2D(3), CCND1(1), CCND3(5), CER1(1), CHD8(2), CREBBP(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(1), CSNK2A2(1), CUL1(1), DAAM1(1), DAAM2(1), DKK4(1), DVL3(1), EP300(3), FZD1(1), FZD3(2), FZD6(2), FZD9(1), JUN(1), LRP6(2), MAPK10(1), MAPK8(2), MYC(1), NFAT5(1), NFATC3(3), NFATC4(3), NKD1(1), NLK(1), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PPP2CB(2), PPP3CA(3), PPP3CB(2), PRICKLE1(2), PRICKLE2(2), PRKACA(1), PRKCG(1), RHOA(2), ROCK1(1), ROCK2(2), SFRP1(2), SFRP4(1), SIAH1(2), SMAD2(3), SMAD3(2), SMAD4(1), TBL1X(3), TBL1XR1(6), TCF7(3), TCF7L2(1), TP53(142), VANGL2(1), WIF1(1), WNT10B(1), WNT11(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT6(1), WNT7A(5), WNT8B(1), WNT9A(1)	111465471	266	203	216	42	41	67	45	16	92	5	<1.00e-15	<5.98e-15
47	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(1), BAK1(1), BID(4), CASP2(2), CASP6(1), CASP8(2), FAS(1), FASLG(1), JUN(1), MAP2K4(18), MAP3K1(53), MAPK10(1), MDM2(1), MYC(1), NFKB1(1), PARP1(1), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TP53(142)	27048450	239	201	189	10	23	45	23	9	111	28	<1.00e-15	<5.98e-15
48	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	AKT1(12), CDKN1B(5), GRB2(1), ILK(2), ITGB1(2), MAPK1(1), MAPK3(1), PDK2(1), PIK3CA(168), PIK3R1(14), PTEN(15), PTK2(1), SHC1(1), SOS1(3)	13484679	227	201	76	8	56	36	96	3	34	2	<1.00e-15	<5.98e-15
49	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(12), EIF4A2(3), EIF4B(1), EIF4G2(1), EIF4G3(2), PDK2(1), PIK3CA(168), PIK3R1(14), PTEN(15), RPS6(1), TSC1(2), TSC2(2)	19119477	222	199	72	10	57	35	95	4	29	2	<1.00e-15	<5.98e-15
50	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT1(12), AKT2(1), AKT3(2), BAD(1), BTK(2), GRB2(1), GSK3A(1), IARS(5), INPP5D(2), PDK1(1), PIK3CA(168), PTEN(15), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(3), SOS2(1), TEC(1), YWHAB(1)	26700648	223	199	74	10	59	38	99	3	22	2	<1.00e-15	<5.98e-15
51	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(12), EIF2B5(1), EIF2S1(1), EIF2S2(1), IGF1(1), IGF1R(1), INPPL1(1), PDK2(1), PIK3CA(168), PIK3R1(14), PTEN(15), RPS6(1)	14779557	217	197	67	13	59	31	95	2	28	2	<1.00e-15	<5.98e-15
52	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(12), CCND1(1), CDK2(1), CDK6(1), CDKN1B(5), E2F1(2), MAPK1(1), MAPK3(1), NFKB1(1), PAK1(2), PIK3CA(168), PIK3R1(14), RAF1(1), RB1(9), RELA(1)	14877408	220	197	69	6	58	34	93	3	32	0	<1.00e-15	<5.98e-15
53	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(3), AKT1(12), CAMK2A(1), CAMK2D(3), GNAS(4), GRB2(1), MAPK1(1), MAPK14(1), MAPK3(1), PIK3CA(168), PIK3R1(14), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1), SOS1(3)	20339319	216	196	66	13	60	38	95	3	20	0	<1.00e-15	<5.98e-15
54	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(12), APC(3), AXIN1(1), CCND1(1), CD14(1), FZD1(1), GJA1(2), GNAI1(1), IRAK1(1), LBP(1), NFKB1(1), PIK3CA(168), PIK3R1(14), RELA(1), TIRAP(2), TLR4(7)	20994363	217	196	66	14	59	36	98	3	21	0	<1.00e-15	<5.98e-15
55	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(12), CABIN1(5), CAMK1(1), CAMK1G(1), IGF1(1), IGF1R(1), INSR(2), MAPK14(1), MEF2A(1), MEF2C(2), PIK3CA(168), PIK3R1(14), PPP3CA(3), PPP3CB(2)	23987184	214	194	64	14	58	36	96	3	21	0	<1.00e-15	<5.98e-15
56	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(12), BAD(1), CRKL(1), E2F1(2), GRB2(1), IL2RG(1), IRS1(1), JAK1(1), JAK3(1), MAPK1(1), MAPK3(1), MYC(1), PIK3CA(168), PIK3R1(14), RAF1(1), SHC1(1), SOS1(3), STAT5B(4)	26422305	215	194	65	13	57	38	95	4	21	0	<1.00e-15	<5.98e-15
57	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(3), AKT1(12), GNAI1(1), GNB1(1), ITGAV(3), ITGB3(2), MAPK1(1), MAPK3(1), PDGFRA(3), PIK3CA(168), PIK3R1(14), PLCB1(3), PTK2(1), SMPD2(2)	19871358	215	193	65	9	62	38	95	2	18	0	<1.00e-15	<5.98e-15
58	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(12), AKT2(1), AKT3(2), BAD(1), GRB2(1), GSK3A(1), IRS1(1), JAK1(1), JAK3(1), MAP4K1(1), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(168), PIK3R1(14), RAF1(1), SHC1(1), SOS1(3), SOS2(1)	25926966	213	193	63	10	56	38	94	3	22	0	<1.00e-15	<5.98e-15
59	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(3), AKT1(12), BAD(1), CSF2RB(2), IGF1(1), IGF1R(1), IL3RA(1), KIT(3), KITLG(2), PIK3CA(168), PIK3R1(14), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	15549183	211	192	61	9	63	33	94	3	18	0	<1.00e-15	<5.98e-15
60	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(12), AKT2(1), AKT3(2), GRB2(1), ILK(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(168), PTEN(15), PTK2B(3), RBL2(1), SHC1(1), SOS1(3)	14801358	212	192	63	5	56	35	96	1	22	2	<1.00e-15	<5.98e-15
61	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(3), GSN(1), ITGA1(3), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), MYLK(5), PIK3CA(168), PIK3R1(14), PTK2(1), PXN(1), RAF1(1), ROCK1(1), SHC1(1), TLN1(7)	28257645	211	191	71	12	56	31	97	5	22	0	<1.00e-15	<5.98e-15
62	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(12), GRB2(1), MAPK1(1), MAPK3(1), MEF2A(1), MEF2C(2), NTRK1(1), PIK3CA(168), PIK3R1(14), PLCG1(4), RPS6KA1(1), SHC1(1)	13869999	207	190	57	7	58	35	91	2	21	0	<1.00e-15	<5.98e-15
63	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(12), BAD(1), GRB2(1), IGF1R(1), IRS1(1), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3CA(168), PIK3R1(14), RAF1(1), SHC1(1), SOS1(3)	14032239	206	190	56	8	57	35	93	2	19	0	<1.00e-15	<5.98e-15
64	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(1), INPP4A(2), INPP4B(3), INPPL1(1), ITPKB(7), OCRL(3), PIK3C2A(2), PIK3C2B(2), PIK3C2G(1), PIK3CA(168), PIK3CB(3), PIK3CG(2), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCG1(4), PLCG2(2)	33169968	214	190	75	13	63	32	97	5	17	0	<1.00e-15	<5.98e-15
65	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(12), GRB2(1), KLK2(2), NTRK1(1), PIK3CA(168), PIK3R1(14), PLCG1(4), SHC1(1), SOS1(3)	11610807	206	190	56	6	57	34	93	2	20	0	<1.00e-15	<5.98e-15
66	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(12), PIK3CA(168), PIK3R1(14), PLCB1(3), PLCG1(4), VAV1(1)	9661899	202	189	52	6	58	33	90	2	19	0	<1.00e-15	<5.98e-15
67	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(12), BAD(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(1), PIK3CA(168), PIK3R1(14), RAF1(1), RELA(1), RHOA(2)	13809159	204	189	54	9	57	34	93	2	18	0	<1.00e-15	<5.98e-15
68	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	27	MAP2K4(18), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), NFKB1(1), NFKB2(4), PIK3CA(168), PIK3R1(14), TRAF6(1)	20489898	213	189	72	8	60	26	91	2	31	3	<1.00e-15	<5.98e-15
69	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(12), AKT2(1), AKT3(2), GRB2(1), IARS(5), IL13RA1(1), IL2RG(1), INPP5D(2), JAK1(1), JAK2(2), JAK3(1), NR0B2(2), PI3(1), PIK3CA(168), SERPINA4(3), SHC1(1), SOS1(3), SOS2(1), TYK2(3)	27222351	211	189	61	11	56	39	98	2	16	0	<1.00e-15	<5.98e-15
70	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GHR(2), GRB2(1), INSR(2), IRS1(1), JAK2(2), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3CA(168), PIK3R1(14), PLCG1(4), RAF1(1), RPS6KA1(1), SHC1(1), SLC2A4(1), SOS1(3), SRF(1), STAT5B(4)	24131679	209	188	69	9	56	30	95	4	24	0	<1.00e-15	<5.98e-15
71	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(3), ARHGEF1(5), F2(2), F2R(2), GNAI1(1), GNAQ(1), GNB1(1), PIK3CA(168), PIK3R1(14), PLCB1(3), PTK2B(3), ROCK1(1)	18676359	204	188	64	7	64	25	92	4	19	0	<1.00e-15	<5.98e-15
72	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(12), BAD(1), CHRNB1(2), CHRNG(1), MUSK(3), PIK3CA(168), PIK3R1(14), PTK2(1), PTK2B(3)	11523096	205	187	54	7	61	32	93	2	17	0	<1.00e-15	<5.98e-15
73	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(12), GNAS(4), GNB1(1), NFKB1(1), NOS3(2), NPPA(1), PIK3CA(168), PIK3R1(14), RELA(1)	12477270	204	186	54	6	56	33	93	3	19	0	<1.00e-15	<5.98e-15
74	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(12), GHR(2), IGF1(1), IGF1R(1), PIK3CA(168), PIK3R1(14), SHC1(1), SOD1(1)	9677109	200	186	50	7	56	31	94	2	17	0	<1.00e-15	<5.98e-15
75	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), HLA-A(4), ITGB1(2), KLRC1(3), KLRC2(1), KLRC3(1), LAT(1), MAP2K1(1), MAPK3(1), PAK1(2), PIK3CA(168), PIK3R1(14), PTK2B(3), VAV1(1)	13901940	204	186	63	8	60	25	93	4	22	0	<1.00e-15	<5.98e-15
76	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), GRB2(1), JAK2(2), JUN(1), MAP2K1(1), MAPK3(1), PIK3CA(168), PIK3R1(14), PLCG1(4), RAF1(1), RASA1(2), SHC1(1), SOS1(3), STAT1(1), STAT3(1), STAT5B(4)	22285692	206	186	66	6	57	27	93	3	26	0	<1.00e-15	<5.98e-15
77	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(12), BAD(1), GHR(2), NFKB1(1), PIK3CA(168), PIK3R1(14), RELA(1)	10681983	199	185	49	6	56	32	91	2	18	0	<1.00e-15	<5.98e-15
78	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	60	APAF1(1), ATM(9), ATR(2), BAI1(6), BID(4), CASP8(2), CCNB1(2), CCNB3(3), CCND1(1), CCND3(5), CCNG2(2), CDK2(1), CDK6(1), CHEK2(2), DDB2(1), FAS(1), GTSE1(4), IGF1(1), IGFBP3(1), MDM2(1), PERP(2), PTEN(15), RRM2(1), SERPINE1(1), SESN2(2), SIAH1(2), STEAP3(1), THBS1(3), TP53(142), TP53I3(1), TSC2(2)	43983264	222	185	174	10	20	56	28	14	97	7	<1.00e-15	<5.98e-15
79	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF2B5(1), EIF2S1(1), EIF2S2(1), ELAVL1(2), FLT1(2), FLT4(1), KDR(2), NOS3(2), PIK3CA(168), PIK3R1(14), PLCG1(4), PTK2(1), PXN(1), SHC1(1)	23495394	203	185	63	15	59	25	94	5	20	0	<1.00e-15	<5.98e-15
80	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), ELK1(2), GRB2(1), JUN(1), KLK2(2), MAP2K1(1), MAPK3(1), MAPK8(2), NGFR(1), PIK3CA(168), PIK3R1(14), PLCG1(4), RAF1(1), SHC1(1), SOS1(3)	14050491	203	184	63	5	57	27	94	2	23	0	<1.00e-15	<5.98e-15
81	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	GNAI1(1), GNAQ(1), GNB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), NFKB1(1), PIK3C2G(1), PIK3CA(168), PIK3R1(14), PLCG1(4), PTK2(1), PTK2B(3), PXN(1), RAF1(1), RELA(1)	19769958	201	183	61	6	59	26	94	2	20	0	<1.00e-15	<5.98e-15
82	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), ELK1(2), GRB2(1), IGF1(1), IGF1R(1), IRS1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PIK3CA(168), PIK3R1(14), RAF1(1), RASA1(2), SHC1(1), SOS1(3), SRF(1)	18177978	202	183	62	7	57	25	96	2	22	0	<1.00e-15	<5.98e-15
83	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(1), ELK1(2), GRB2(1), INSR(2), IRS1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PIK3CA(168), PIK3R1(14), RAF1(1), RASA1(2), SHC1(1), SLC2A4(1), SOS1(3), SRF(1)	18530850	203	183	63	8	56	26	96	3	22	0	<1.00e-15	<5.98e-15
84	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(9), CCNB1(2), CCND1(1), CCND3(5), CCNG2(2), CDK2(1), CDK7(1), CDKN1B(5), CREB3(1), CREB3L1(2), CREB3L3(1), E2F1(2), E2F3(1), E2F4(2), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(1), MNAT1(1), MYC(1), NACA(3), ORC2L(1), ORC3L(1), POLE2(1), RB1(9), RBL1(1), RPA1(1), TFDP2(1), TNXB(3), TP53(142)	56141124	209	180	160	12	26	48	26	10	96	3	<1.00e-15	<5.98e-15
85	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(2), EP300(3), IL2RG(1), JAK1(1), JAK3(1), PIK3CA(168), PIK3R1(14), PTK2B(3), STAT5B(4)	20444775	197	178	56	9	58	22	90	5	22	0	<1.00e-15	<5.98e-15
86	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(12), AKT2(1), AKT3(2), ELK1(2), GRB2(1), MAP2K1(1), NGFR(1), NTRK1(1), PIK3CA(168), SHC1(1), SOS1(3)	11119524	193	178	44	6	55	33	92	1	12	0	<1.00e-15	<5.98e-15
87	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3E(1), CD3G(1), CD86(1), GRB2(1), HLA-DRB1(2), IL2(1), ITK(3), PIK3CA(168), PIK3R1(14)	9665448	192	177	52	10	55	24	92	4	17	0	<1.00e-15	<5.98e-15
88	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1A(1), ARPC1B(1), ARPC2(2), PAK1(2), PDGFRA(3), PIK3CA(168), PIK3R1(14), WASL(1)	10121241	192	176	52	10	60	19	92	3	18	0	<1.00e-15	<5.98e-15
89	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(9), ATR(2), BRCA1(8), BRCA2(10), CHEK2(2), FANCA(2), FANCD2(3), FANCF(1), FANCG(1), RAD17(2), RAD50(1), RAD9A(2), TP53(142)	33361107	185	169	137	7	18	43	24	11	89	0	<1.00e-15	<5.98e-15
90	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(12), APAF1(1), ATM(9), BAD(1), BID(4), CASP6(1), EIF2S1(1), PTK2(1), PXN(1), STAT1(1), TLN1(7), TP53(142)	20568990	181	167	123	6	17	53	22	9	80	0	<1.00e-15	<5.98e-15
91	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(9), ATR(2), BRCA1(8), CCNB1(2), CDC25B(3), CHEK2(2), EP300(3), MDM2(1), PRKDC(7), RPS6KA1(1), TP53(142)	32064708	180	164	131	9	19	46	23	11	81	0	<1.00e-15	<5.98e-15
92	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(12), EGFR(4), IGF1R(1), MYC(1), POLR2A(2), RB1(9), TEP1(7), TP53(142)	20513220	178	164	120	8	16	50	22	12	78	0	<1.00e-15	<5.98e-15
93	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(2), ATM(9), ATR(2), CCND1(1), CDK2(1), CDK6(1), CDKN1B(5), E2F1(2), HDAC1(2), RB1(9), TGFB3(1), TP53(142)	22265919	177	163	128	7	17	41	21	9	89	0	<1.00e-15	<5.98e-15
94	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(3), AKT1(12), ATM(9), CPB2(1), IGFBP3(1), MAPK8(2), MDM2(1), NQO1(1), TP53(142)	14946867	172	161	114	12	15	51	23	9	74	0	<1.00e-15	<5.98e-15
95	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(2), ATM(9), BRCA1(8), CHEK2(2), JUN(1), MAPK8(2), MDM2(1), NFKB1(1), RAD50(1), RELA(1), TP53(142)	21702135	170	158	122	6	16	41	20	11	82	0	<1.00e-15	<5.98e-15
96	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(1), ATM(9), CCND1(1), CDK2(1), E2F1(2), MDM2(1), RB1(9), TP53(142)	13341705	166	157	118	4	17	38	21	8	82	0	<1.00e-15	<5.98e-15
97	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(9), CDC25B(3), CDK2(1), RB1(9), TP53(142)	13226616	164	155	116	6	15	38	19	10	82	0	<1.00e-15	<5.98e-15
98	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(2), PAX3(2), RARA(1), RB1(9), SP100(4), TNFRSF1A(1), TP53(142)	13647933	161	153	113	7	16	36	22	8	79	0	<1.00e-15	<5.98e-15
99	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(1), IKBKB(2), JAK2(2), NFKB1(1), RB1(9), RELA(1), TNFRSF1A(1), TP53(142), USH1C(1), WT1(1)	13158678	161	151	113	6	17	37	19	7	81	0	<1.00e-15	<5.98e-15
100	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), CCND1(1), CDK2(1), CDKN1B(5), E2F1(2), MDM2(1), TP53(142)	5855343	153	149	104	3	18	33	20	7	75	0	<1.00e-15	<5.98e-15
101	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(9), ATR(2), CHEK2(2), TP53(142)	12199941	155	148	107	5	15	39	19	9	73	0	<1.00e-15	<5.98e-15
102	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), MAX(1), MYC(1), SP1(1), SP3(3), TP53(142), WT1(1)	5161260	151	144	103	5	16	35	20	8	72	0	<1.00e-15	<5.98e-15
103	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	DNAJC3(2), EIF2S1(1), EIF2S2(1), NFKB1(1), RELA(1), TP53(142)	7230834	148	141	100	3	16	35	20	7	70	0	<1.00e-15	<5.98e-15
104	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACTB(2), ACTG1(1), ACTN2(4), ACTN3(1), ACTN4(4), ACVR1B(4), ACVR1C(1), BAIAP2(1), CDH1(31), CREBBP(2), CSNK2A1(1), CSNK2A2(1), CTNNA1(1), CTNNA2(2), CTNNA3(2), CTNND1(1), EGFR(4), EP300(3), ERBB2(4), FARP2(3), IGF1R(1), INSR(2), IQGAP1(1), MAPK1(1), MAPK3(1), MET(4), MLLT4(7), NLK(1), PARD3(3), PTPRB(2), PTPRF(3), PTPRJ(1), PTPRM(2), PVRL1(1), PVRL2(3), PVRL3(1), RHOA(2), SMAD2(3), SMAD3(2), SMAD4(1), SNAI1(1), SNAI2(1), SORBS1(4), SSX2IP(1), TCF7(3), TCF7L2(1), TGFBR1(2), TJP1(4), VCL(3), WAS(1), WASF1(1), WASF3(1), WASL(1), YES1(1)	87978696	140	120	137	35	25	31	17	7	57	3	6.22e-15	3.68e-14
105	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	AKT1(12), AKT2(1), AKT3(2), ARHGEF11(1), LPA(5), MAP2K4(18), MAP3K1(53), MAP3K5(1), MAPK8(2), NFKB1(1), NFKB2(4), PDK1(1), PHKA2(4), PI3(1), PIK3CB(3), PLD1(1), PLD3(1), PTK2(1), RDX(1), ROCK1(1), ROCK2(2), SERPINA4(3), SRF(1)	35629425	120	91	108	9	12	25	9	1	42	31	7.55e-15	4.43e-14
106	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(1), CASP6(1), CASP8(2), DFFB(2), JUN(1), LMNB1(1), MAP2K4(18), MAP3K1(53), MAPK8(2), PAK1(2), PAK2(1), PRKDC(7), PTPN13(4), RB1(9), SPTAN1(2)	31114590	106	84	104	4	11	8	9	3	47	28	8.88e-15	5.16e-14
107	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	IKBKB(2), IL1A(1), IL1R1(1), IRAK1(1), MAP3K1(53), NFKB1(1), RELA(1), RIPK1(3), TLR4(7), TNFAIP3(1), TNFRSF1A(1), TRAF6(1)	17466150	73	53	71	7	4	10	5	0	26	28	1.13e-14	6.52e-14
108	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	26	CRKL(1), GNAQ(1), GRB2(1), JUN(1), MAP2K1(1), MAP2K3(1), MAP2K4(18), MAP3K1(53), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(4), PTK2B(3), RAF1(1), SHC1(1), SOS1(3)	19511895	96	75	94	4	9	11	8	1	39	28	1.14e-14	6.52e-14
109	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	91	ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), ATF4(1), CACNA1C(4), CACNA1D(4), CACNA1F(6), CACNA1S(1), CAMK2A(1), CAMK2D(3), EGFR(4), ELK1(2), GNAQ(1), GNAS(4), GNRH2(1), GRB2(1), ITPR1(7), ITPR3(4), JUN(1), KRAS(1), LHB(1), MAP2K1(1), MAP2K3(1), MAP2K4(18), MAP3K1(53), MAP3K4(3), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MMP14(3), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PLD1(1), PRKACA(1), PTK2B(3), RAF1(1), SOS1(3), SOS2(1)	92365767	184	139	179	37	26	43	26	9	52	28	1.35e-14	7.65e-14
110	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	23	CASP2(2), IKBKB(2), JUN(1), MAP2K3(1), MAP2K4(18), MAP3K1(53), MAPK14(1), MAPK8(2), NFKB1(1), RELA(1), RIPK1(3), TANK(1), TNFRSF1A(1)	17076774	87	67	85	4	5	11	4	1	38	28	1.39e-14	7.77e-14
111	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(2), EGFR(4), MAP2K1(1), MAP3K1(53), MAPK14(1), NCOR2(3), RARA(1), THRB(1)	11236134	66	48	65	5	4	4	2	4	24	28	1.48e-14	8.19e-14
112	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	EGF(2), EGFR(4), ETS1(2), ETS2(3), HOXA7(1), IKBKB(2), JUN(1), MAP2K1(1), MAP2K3(1), MAP2K4(18), MAP3K1(53), MAP3K5(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(1), PRKCG(1), PRKCH(1), PRKCQ(2), RAF1(1), RELA(1), RIPK1(3), SP1(1), TNFRSF1A(1)	35395191	106	85	104	15	10	15	10	5	38	28	1.53e-14	8.39e-14
113	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(3), CDH1(31), CREBBP(2), EP300(3), MAP2K1(1), MAPK3(1), SKIL(1), TGFB3(1), TGFBR1(2)	18997797	45	44	42	5	1	9	4	1	30	0	1.54e-14	8.39e-14
114	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	IKBKB(2), IL2(1), JUN(1), MAP3K1(53), MAP3K5(1), MAPK14(1), MAPK8(2), NFKB1(1), RELA(1)	14513889	63	46	62	4	2	6	2	0	25	28	1.55e-14	8.39e-14
115	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	EGR2(1), EGR3(3), GNAQ(1), MAP3K1(53), MYC(1), NFKB1(1), PLCG1(4), PPP3CA(3), PPP3CB(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RELA(1), VIP(1)	19685289	74	56	73	7	6	7	4	1	28	28	1.57e-14	8.39e-14
116	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	IKBKAP(3), IKBKB(2), MAP3K1(53), NFKB1(1), RELA(1), RIPK1(3), TANK(1), TNFAIP3(1)	16616418	65	47	64	6	2	8	3	0	24	28	1.59e-14	8.43e-14
117	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(2), CD79A(1), ELK1(2), GRB2(1), JUN(1), LYN(3), MAP2K1(1), MAP3K1(53), MAPK14(1), MAPK3(1), MAPK8(2), NFATC3(3), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CB(2), RAF1(1), SHC1(1), SOS1(3), VAV1(1)	27743547	90	70	89	6	4	16	13	0	29	28	1.64e-14	8.65e-14
118	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	26	ARHGDIB(1), BAG4(1), CASP2(2), CASP8(2), DFFB(2), JUN(1), LMNB1(1), MADD(7), MAP2K4(18), MAP3K1(53), MAPK8(2), PAK1(2), PAK2(1), PRKDC(7), RB1(9), RIPK1(3), SPTAN1(2), TNFRSF1A(1)	28758561	115	89	113	6	11	15	9	3	49	28	1.71e-14	8.93e-14
119	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	124	ALCAM(1), CADM1(1), CD2(2), CD22(1), CD226(2), CD274(1), CD276(1), CD34(1), CD4(1), CD40(1), CD40LG(1), CD86(1), CD8A(1), CD99(2), CDH1(31), CDH2(1), CDH4(2), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN6(1), CNTN1(4), CNTN2(4), CNTNAP1(3), CNTNAP2(3), ESAM(2), F11R(1), GLG1(2), HLA-A(4), HLA-C(3), HLA-DMA(1), HLA-DMB(2), HLA-DQB1(1), HLA-DRB1(2), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), ICOSLG(1), ITGA4(1), ITGA6(3), ITGA8(2), ITGAL(1), ITGAM(1), ITGAV(3), ITGB1(2), ITGB2(3), ITGB8(1), L1CAM(1), MAG(1), MPZL1(1), NCAM1(4), NCAM2(2), NEO1(3), NFASC(4), NLGN1(1), NLGN3(3), NRCAM(1), NRXN1(1), NRXN2(3), NRXN3(5), PTPRC(1), PTPRF(3), PTPRM(2), PVRL1(1), PVRL2(3), PVRL3(1), SDC4(1), SELE(1), SELL(4), SELP(3), SELPLG(1), SIGLEC1(1), SPN(2), VCAM1(2), VCAN(7)	106226133	176	132	172	44	36	38	35	11	56	0	1.73e-14	8.97e-14
120	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	IKBKAP(3), IKBKB(2), MAP3K1(53), NFKB1(1), RELA(1), TNFAIP3(1), TRAF6(1)	13432965	62	44	61	5	2	7	2	0	23	28	1.80e-14	9.23e-14
121	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(1), CASP8(2), MAP2K1(1), MAP2K4(18), MAP3K1(53), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(1), NSMAF(2), RAF1(1), RELA(1), RIPK1(3), TNFRSF1A(1)	14909349	88	69	85	4	6	9	7	0	38	28	1.83e-14	9.33e-14
122	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	49	ACTG1(1), APAF1(1), ARHGDIB(1), BAG4(1), BID(4), CASP2(2), CASP6(1), CASP8(2), DFFB(2), GSN(1), LMNB1(1), MAP3K1(53), MAP3K5(1), MAPK8(2), MDM2(1), NFKB1(1), NUMA1(2), PAK2(1), PRKDC(7), PSEN2(2), PTK2(1), RASA1(2), RB1(9), RELA(1), RIPK1(3), SPTAN1(2), TNFRSF1A(1)	50633076	106	84	105	7	6	18	12	2	40	28	1.95e-14	9.79e-14
123	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	ELK1(2), GRB2(1), MAP2K4(18), MAP3K1(53), MAP3K5(1), MAP3K9(1), MAPK14(1), MAX(1), MEF2A(1), MEF2C(2), MYC(1), PLA2G4A(6), RIPK1(3), SHC1(1), STAT1(1), TGFB3(1), TGFBR1(2)	26936403	96	74	93	8	9	10	8	2	39	28	1.95e-14	9.79e-14
124	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(3), EGFR(4), ELK1(2), GNAQ(1), GRB2(1), JUN(1), MAP2K1(1), MAP2K4(18), MAP3K1(53), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(1), MEF2C(2), PAK1(2), PTK2(1), PTK2B(3), RAF1(1), SHC1(1), SOS1(3)	24519534	102	80	100	5	9	13	9	4	39	28	2.05e-14	1.02e-13
125	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	IFNB1(1), IKBKB(2), IL1A(1), IL1R1(1), IL1RAP(2), IL1RN(2), IL6(2), IRAK1(1), IRAK2(2), IRAK3(1), JUN(1), MAP2K3(1), MAP3K1(53), MAPK14(1), MAPK8(2), NFKB1(1), RELA(1), TGFB3(1), TRAF6(1)	21342165	77	57	76	6	5	12	4	1	27	28	2.24e-14	1.11e-13
126	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CAMK1(1), CAMK1G(1), ELK1(2), FPR1(1), GNB1(1), MAP2K1(1), MAP2K3(1), MAP3K1(53), MAPK1(1), MAPK14(1), MAPK3(1), NCF2(2), NFATC3(3), NFATC4(3), NFKB1(1), PAK1(2), PIK3C2G(1), PLCB1(3), PPP3CA(3), PPP3CB(2), RAF1(1), RELA(1)	27524016	86	66	85	11	7	12	14	1	24	28	2.30e-14	1.12e-13
127	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	GATA3(55), MAP2K3(1), MAPK14(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	7453914	60	58	37	6	3	3	0	1	51	2	2.34e-14	1.13e-13
128	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	BCR(1), BLNK(1), ELK1(2), GRB2(1), JUN(1), LYN(3), MAP2K1(1), MAP3K1(53), MAPK1(1), MAPK3(1), PAPPA(4), RPS6KA1(1), RPS6KA3(2), SHC1(1), SOS1(3), VAV1(1), VAV3(1)	21072441	78	60	77	4	5	14	7	0	24	28	2.35e-14	1.13e-13
129	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	89	ACTB(2), BAD(1), CABIN1(5), CD3E(1), CD3G(1), CD69(1), CNR1(1), CREBBP(2), CSNK2A1(1), EGR2(1), EGR3(3), EP300(3), FCER1A(2), GATA3(55), GRLF1(4), GSK3A(1), IFNB1(1), IL2(1), IL6(2), ITK(3), KPNA5(1), MAPK14(1), MAPK8(2), MEF2A(1), NFAT5(1), NFATC3(3), NFATC4(3), NFKB2(4), NUP214(4), OPRD1(1), P2RX7(1), PAK1(2), PPP3CB(2), PTPRC(1), RELA(1), RPL13A(2), SP1(1), SP3(3), TRPV6(1), VAV1(1), VAV3(1), XPO5(1)	65388804	129	115	105	31	14	17	18	3	72	5	2.53e-14	1.21e-13
130	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(1), ELK1(2), IKBKB(2), IRAK1(1), JUN(1), MAP2K3(1), MAP2K4(18), MAP3K1(53), MAPK14(1), MAPK8(2), NFKB1(1), PPARA(1), RELA(1), TIRAP(2), TLR10(1), TLR2(1), TLR3(1), TLR4(7), TLR7(3), TRAF6(1)	26549562	101	78	98	6	9	13	7	0	44	28	2.65e-14	1.26e-13
131	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	79	BRAF(2), ELK1(2), GRB2(1), IKBKB(2), JUN(1), MAP2K1(1), MAP2K3(1), MAP2K4(18), MAP2K5(1), MAP3K1(53), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(3), MAP3K4(3), MAP3K5(1), MAP3K6(1), MAP3K8(2), MAP3K9(1), MAP4K1(1), MAP4K4(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK4(2), MAPK6(1), MAPK8(2), MAPKAPK3(1), MAX(1), MEF2A(1), MEF2C(2), MYC(1), NFKB1(1), PAK1(2), PAK2(1), RAF1(1), RELA(1), RIPK1(3), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KB2(3), SHC1(1), SP1(1), STAT1(1), TGFB3(1), TGFBR1(2)	67732665	141	114	139	13	17	26	14	4	52	28	2.74e-14	1.29e-13
132	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTB(2), ACTG1(1), ARHGEF2(1), CD14(1), CDH1(31), CTTN(1), EZR(2), HCLS1(1), ITGB1(2), KRT18(1), NCL(1), RHOA(2), ROCK1(1), ROCK2(2), TLR4(7), TLR5(1), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2B(1), TUBB2C(2), TUBB4(1), WAS(1), WASL(1)	39551577	70	63	67	13	6	13	10	3	38	0	5.68e-13	2.63e-12
133	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTB(2), ACTG1(1), ARHGEF2(1), CD14(1), CDH1(31), CTTN(1), EZR(2), HCLS1(1), ITGB1(2), KRT18(1), NCL(1), RHOA(2), ROCK1(1), ROCK2(2), TLR4(7), TLR5(1), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2B(1), TUBB2C(2), TUBB4(1), WAS(1), WASL(1)	39551577	70	63	67	13	6	13	10	3	38	0	5.68e-13	2.63e-12
134	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	126	ACTB(2), ACTG1(1), ACTN2(4), ACTN3(1), ACTN4(4), AKT1(12), AKT2(1), AKT3(2), ASH1L(4), CASK(2), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN6(1), CRB3(1), CSNK2A1(1), CSNK2A2(1), CTNNA1(1), CTNNA2(2), CTNNA3(2), CTTN(1), EPB41(1), EPB41L1(4), EPB41L2(2), EPB41L3(3), EXOC3(1), EXOC4(1), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), IGSF5(3), INADL(5), KRAS(1), LLGL1(1), LLGL2(5), MAGI1(3), MAGI2(6), MAGI3(3), MLLT4(7), MPDZ(2), MYH1(4), MYH10(4), MYH11(5), MYH13(2), MYH14(5), MYH15(5), MYH2(1), MYH3(1), MYH4(4), MYH6(7), MYH7(6), MYH7B(5), MYH8(4), MYH9(5), MYL7(1), PARD3(3), PARD6B(1), PPP2CB(2), PPP2R3A(3), PPP2R4(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKCZ(1), PTEN(15), RHOA(2), SPTAN1(2), SYMPK(3), TJP1(4), TJP3(2), VAPA(1), YES1(1), ZAK(1)	140757903	206	161	195	69	35	60	46	14	47	4	3.63e-12	1.67e-11
135	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(4), ASH2L(3), CARM1(1), CTCFL(1), DOT1L(3), EED(2), EZH1(1), HCFC1(5), KDM6A(5), MEN1(1), MLL(5), MLL2(6), MLL3(30), MLL4(4), MLL5(4), OGT(2), PRDM2(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1), RBBP5(1), SATB1(2), SETD2(4), SETD7(1), SETDB1(7), SETMAR(2), SMYD3(3), SUV420H1(2), SUZ12(3), WHSC1(4), WHSC1L1(1)	86453133	115	102	114	17	19	24	19	8	43	2	1.45e-10	6.62e-10
136	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	ATM(9), BMPR1B(2), CDKN1B(5), DMC1(2), EGR1(1), ESR2(2), FSHR(3), GJA4(1), LHCGR(4), NCOR1(16), PGR(2), PRLR(1), ZP2(1)	25400700	49	45	48	9	2	10	5	5	25	2	1.95e-09	8.85e-09
137	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	32	AKT1(12), CREB3(1), DUSP10(1), EEF2K(2), ELK1(2), IL1R1(1), MAP2K3(1), MAP2K4(18), MAP3K10(4), MAP3K4(3), MAP3K5(1), MAPK1(1), MAPK14(1), MYEF2(1), NFKB1(1), SRF(1), TRAF6(1)	23536461	52	48	41	8	7	20	11	0	14	0	2.11e-08	9.50e-08
138	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	126	ACTB(2), ACTG1(1), COL11A1(2), COL11A2(1), COL17A1(3), COL1A1(6), COL1A2(3), COL2A1(3), COL3A1(1), COL4A1(4), COL4A2(2), COL4A4(1), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A3(5), COL6A6(4), COMP(3), DSC2(3), DSC3(1), DSG1(2), DSG4(2), FN1(3), GJA1(2), GJA10(1), GJA4(1), GJA9(1), GJB2(1), GJB3(2), GJB4(1), GJB5(1), GJC1(1), INA(1), ITGA6(3), ITGB4(4), KRT1(3), KRT14(1), KRT15(1), KRT17(4), KRT18(1), KRT19(2), KRT2(2), KRT25(2), KRT28(1), KRT3(1), KRT33A(1), KRT34(1), KRT35(1), KRT36(2), KRT37(1), KRT4(2), KRT6A(1), KRT6C(1), KRT71(1), KRT72(1), KRT81(1), KRT82(2), KRT83(1), KRT84(1), KRT85(1), KRT86(1), KRT9(2), LAMA1(6), LAMA2(7), LAMA3(6), LAMA4(4), LAMB1(3), LAMB2(3), LAMB3(4), LAMB4(6), LAMC1(2), LAMC2(1), LAMC3(1), LMNB1(1), NES(3), RELN(10), SPP1(1), THBS1(3), THBS3(1), THBS4(1), TNC(3), TNN(3), TNR(1), TNXB(3), VWF(6)	166605270	202	161	201	72	41	74	42	10	35	0	5.43e-08	2.42e-07
139	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	21	APC(3), CERK(1), CREB3(1), EPHB2(1), GNAQ(1), ITPKB(7), JUN(1), MAP2K4(18), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1)	17847414	38	36	37	4	7	6	4	3	18	0	1.76e-07	7.78e-07
140	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(2), CPEB1(2), EGFR(4), ERBB2(4), ERBB4(4), ETS1(2), ETS2(3), ETV6(1), FMN2(7), GRB2(1), KRAS(1), MAP2K1(1), MAPK1(1), MAPK3(1), NOTCH2(4), NOTCH3(3), NOTCH4(6), PIWIL1(8), PIWIL2(4), PIWIL4(1), RAF1(1), SOS1(3), SOS2(1), SPIRE1(1)	34373079	66	57	65	13	10	22	15	7	12	0	7.15e-07	3.15e-06
141	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDK2(1), CDKN1B(5), CUL1(1), E2F1(2), RB1(9)	6357780	18	18	17	0	1	1	2	0	14	0	7.84e-07	3.42e-06
142	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNB1(2), CCND1(1), CCND3(5), CDK2(1), CDK6(1), CDK7(1), CDKN1B(5), E2F1(2), RB1(9), RBL1(1)	11409021	28	25	27	3	4	2	2	2	15	3	1.03e-06	4.46e-06
143	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	63	ADAM10(1), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), EGFR(4), F11R(1), GIT1(1), IGSF5(3), IKBKB(2), JUN(1), LYN(3), MAP2K4(18), MAPK10(1), MAPK14(1), MAPK8(2), MET(4), NFKB1(1), NFKB2(4), NOD1(3), PAK1(2), PLCG1(4), PLCG2(2), PTPRZ1(4), RELA(1), TCIRG1(1), TJP1(4)	50633583	78	70	77	11	13	16	10	10	23	6	2.95e-06	0.000013
144	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	84	ACVR1(1), ACVR1B(4), ACVR1C(1), ACVR2A(3), AMHR2(2), BMP2(2), BMP4(2), BMP5(1), BMP6(1), BMP8B(1), BMPR1B(2), BMPR2(2), CHRD(2), COMP(3), CREBBP(2), CUL1(1), E2F4(2), EP300(3), FST(1), GDF6(2), ID2(1), INHBA(1), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(2), MAPK1(1), MAPK3(1), MYC(1), NODAL(1), PITX2(1), PPP2CB(2), RBL1(1), RBL2(1), RHOA(2), ROCK1(1), ROCK2(2), RPS6KB2(3), SMAD2(3), SMAD3(2), SMAD4(1), SMAD9(2), SMURF2(1), SP1(1), TGFB3(1), TGFBR1(2), THBS1(3), THBS3(1), THBS4(1), ZFYVE16(3), ZFYVE9(3)	70610904	86	77	84	29	13	23	18	7	25	0	2.99e-06	0.000013
145	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(12), AP2A1(3), AP2M1(2), ARF1(1), BAD(1), BTK(2), EEA1(1), GSK3A(1), LYN(3), PFKM(3), PFKP(2), PLCG1(4), PRKCZ(1)	16983993	36	36	26	10	6	18	4	2	6	0	5.05e-06	0.000021
146	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	163	ADCY1(3), ADCY3(2), ADCY4(1), ADCY7(1), ADCY8(2), ADCY9(5), ADRA1A(1), ADRA1B(1), ATP2A1(2), ATP2B1(4), ATP2B2(4), ATP2B3(4), ATP2B4(1), AVPR1B(1), BDKRB1(2), CACNA1A(5), CACNA1B(1), CACNA1C(4), CACNA1D(4), CACNA1E(8), CACNA1F(6), CACNA1G(5), CACNA1I(2), CACNA1S(1), CAMK2A(1), CAMK2D(3), CD38(2), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CYSLTR1(1), CYSLTR2(1), EDNRB(1), EGFR(4), ERBB2(4), ERBB3(8), ERBB4(4), F2R(2), GNAQ(1), GNAS(4), GRIN1(1), GRIN2A(9), GRIN2C(4), GRIN2D(3), GRM1(2), GRM5(1), GRPR(1), HRH2(2), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(3), ITPKB(7), ITPR1(7), ITPR3(4), LHCGR(4), LTB4R2(1), MYLK(5), NOS1(3), NOS3(2), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), PDE1A(2), PDE1B(1), PDGFRA(3), PDGFRB(2), PHKA2(4), PHKB(2), PHKG2(1), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(2), PLCE1(5), PLCG1(4), PLCG2(2), PLCZ1(1), PPP3CA(3), PPP3CB(2), PRKACA(1), PRKCG(1), PTGER3(2), PTGFR(1), PTK2B(3), RYR1(5), RYR2(13), RYR3(11), SPHK2(2), TACR2(1), TNNC2(1), TRPC1(2), VDAC2(1)	195029211	272	180	271	108	77	80	57	22	32	4	0.000012	0.000052
147	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), RB1(9), SP1(1), SP3(3)	5061888	14	14	14	2	0	0	3	0	11	0	0.000051	0.00021
148	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(12), AKT2(1), AKT3(2), BRAF(2), DRD2(1), EGFR(4), EPHB2(1), GRB2(1), ITPKB(7), ITPR1(7), ITPR3(4), KCNJ3(1), MAPK1(1), PI3(1), PIK3CB(3), PITX2(1), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), RAF1(1), RGS20(1), SHC1(1), SOS1(3), SOS2(1), STAT3(1), TERF2IP(2)	43331262	71	65	61	12	11	30	10	8	12	0	0.000087	0.00036
149	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	82	CD36(1), COL11A1(2), COL11A2(1), COL1A1(6), COL1A2(3), COL2A1(3), COL3A1(1), COL4A1(4), COL4A2(2), COL4A4(1), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A3(5), COL6A6(4), FN1(3), FNDC1(4), FNDC3A(1), GP1BA(3), GP6(1), HSPG2(5), ITGA1(3), ITGA10(1), ITGA11(4), ITGA2(2), ITGA2B(2), ITGA4(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGAV(3), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB8(1), LAMA1(6), LAMA2(7), LAMA3(6), LAMA4(4), LAMB1(3), LAMB2(3), LAMB3(4), LAMB4(6), LAMC1(2), LAMC2(1), LAMC3(1), RELN(10), SDC4(1), SPP1(1), SV2A(1), SV2B(1), THBS1(3), THBS3(1), THBS4(1), TNC(3), TNN(3), TNR(1), TNXB(3), VWF(6)	157698294	178	142	177	70	34	61	44	8	31	0	0.00014	0.00058
150	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	90	ANK2(4), B3GALT4(2), DGKI(5), IL6ST(3), RPL13A(2), RPL17(1), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL29(1), RPL35(2), RPL36(1), RPL3L(1), RPL4(1), RPL41(1), RPL5(2), RPLP2(1), RPS10(1), RPS14(1), RPS2(1), RPS21(1), RPS27(1), RPS4X(1), RPS5(2), RPS6(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3), RPS6KB2(3), TBC1D10C(2), UBC(6)	37966695	59	56	59	11	16	9	18	9	7	0	0.00025	0.0010
151	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), LPO(5), MPO(1), PRDX1(1), TPO(6), TYR(3)	6880497	17	17	17	2	2	7	4	0	4	0	0.00029	0.0012
152	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(1), CASP8(2), JUN(1), MAP2K4(18), NFKB1(1), NFKB2(4), RIPK1(3), TNFAIP3(1), TNFRSF1A(1)	19054074	32	29	31	8	6	4	3	0	16	3	0.00037	0.0015
153	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(3), CD14(1), CD19(1), CD1B(2), CD1C(2), CD1D(2), CD1E(1), CD2(2), CD22(1), CD33(1), CD34(1), CD36(1), CD37(1), CD38(2), CD3E(1), CD3G(1), CD4(1), CD5(2), CD55(2), CD8A(1), CD9(1), CR1(6), CR2(2), CSF1(2), CSF2RA(1), CSF3R(2), DNTT(2), EPOR(1), FCGR1A(1), FLT3(2), FLT3LG(1), GP1BA(3), HLA-DRB1(2), HLA-DRB5(1), IL11RA(1), IL1A(1), IL1R1(1), IL1R2(3), IL3RA(1), IL5RA(1), IL6(2), IL6R(1), ITGA1(3), ITGA2(2), ITGA2B(2), ITGA4(1), ITGA6(3), ITGAM(1), ITGB3(2), KIT(3), KITLG(2), TFRC(1), TPO(6)	61738911	93	78	93	26	17	28	25	7	16	0	0.00042	0.0017
154	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CDK2(1), CUL1(1), E2F1(2), FBXW7(1), RB1(9)	6048003	14	14	14	0	1	1	3	0	9	0	0.00042	0.0017
155	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(1), FADS2(4), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2)	7195851	20	19	18	1	3	5	6	5	1	0	0.00057	0.0023
156	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(12), CAV1(1), CHRM1(2), CHRNA1(1), FLT1(2), FLT4(1), KDR(2), NOS3(2), PDE2A(3), PDE3A(6), PDE3B(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKG1(1), PRKG2(4), RYR2(13)	28407717	54	50	44	24	12	23	11	5	3	0	0.00063	0.0025
157	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	242	ACVR1(1), ACVR1B(4), ACVR2A(3), AMHR2(2), BMP2(2), BMPR1B(2), BMPR2(2), CCL11(1), CCL13(1), CCL21(1), CCL23(1), CCL7(1), CCR2(4), CCR3(1), CCR7(2), CD40(1), CD40LG(1), CNTFR(1), CSF1(2), CSF2RA(1), CSF2RB(2), CSF3R(2), CX3CR1(2), EDA2R(1), EGF(2), EGFR(4), EPOR(1), FAS(1), FASLG(1), FLT1(2), FLT3(2), FLT3LG(1), FLT4(1), GH2(1), GHR(2), HGF(3), IFNA10(1), IFNA14(1), IFNA2(2), IFNA4(1), IFNAR2(1), IFNB1(1), IFNK(1), IL10RA(1), IL10RB(3), IL11RA(1), IL12A(1), IL12B(1), IL12RB1(2), IL13RA1(1), IL15(1), IL17B(2), IL17RA(2), IL17RB(3), IL18R1(1), IL18RAP(2), IL1A(1), IL1R1(1), IL1R2(3), IL1RAP(2), IL2(1), IL21(1), IL21R(1), IL22(1), IL22RA1(1), IL22RA2(1), IL23R(3), IL25(1), IL28B(3), IL28RA(1), IL2RG(1), IL3RA(1), IL5RA(1), IL6(2), IL6R(1), IL6ST(3), INHBA(1), INHBC(1), INHBE(1), KDR(2), KIT(3), KITLG(2), LEPR(3), LIF(3), LIFR(4), MET(4), NGFR(1), OSMR(3), PDGFB(1), PDGFRA(3), PDGFRB(2), PLEKHO2(1), PRLR(1), TGFB3(1), TGFBR1(2), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(2), TNFRSF1A(1), TNFRSF21(2), TNFRSF8(1), TNFSF13B(1), TNFSF18(1), TNFSF4(1), TPO(6), TSLP(1), XCR1(1)	127619505	180	137	178	55	45	49	35	17	31	3	0.00077	0.0030
158	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CDK2(1), CUL1(1), E2F1(2), RB1(9)	6195033	13	13	13	0	1	1	2	0	9	0	0.0014	0.0054
159	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	67	ACACB(8), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(2), AKT1(12), AKT2(1), AKT3(2), CAMKK1(3), CAMKK2(2), CD36(1), CPT1A(2), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(2), IRS1(1), IRS4(1), JAK1(1), JAK2(2), JAK3(1), LEPR(3), MAPK10(1), MAPK8(2), NFKB1(1), NFKB2(4), NPY(1), PCK1(1), PCK2(1), PPARA(1), PPARGC1A(1), PRKAA2(2), PRKAB1(1), PRKAG2(1), PRKAG3(2), PRKCQ(2), RELA(1), SLC2A4(1), STAT3(1), TNFRSF1A(1), TYK2(3)	59561346	79	68	68	20	13	36	9	4	14	3	0.0018	0.0068
160	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	B2M(2), CALR(1), CD4(1), CD74(1), CD8A(1), CIITA(3), CTSB(1), CTSS(1), HLA-A(4), HLA-C(3), HLA-DMA(1), HLA-DMB(2), HLA-DQB1(1), HLA-DRB1(2), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), HSP90AA1(2), HSP90AB1(2), IFNA10(1), IFNA14(1), IFNA2(2), IFNA4(1), KIR2DL3(1), KIR2DL4(1), KIR2DS4(1), KIR3DL2(4), KIR3DL3(1), KLRC1(3), KLRC2(1), KLRC3(1), NFYB(1), RFXANK(1), TAP1(1)	35103666	56	49	55	16	8	16	13	5	14	0	0.0018	0.0070
161	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(2), ALDH1A2(1), BCMO1(3), RDH5(2)	2893449	8	8	8	3	1	4	0	0	3	0	0.0019	0.0071
162	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA2(2), CCND1(1), CDK2(1), CDKN1B(5), E2F1(2), E2F4(2)	6082986	13	13	12	0	2	1	2	0	8	0	0.0019	0.0071
163	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	220	ADCYAP1R1(3), ADORA1(1), ADORA3(1), ADRA1A(1), ADRA1B(1), ADRA2B(1), AVPR1B(1), BDKRB1(2), BRS3(1), CALCR(1), CALCRL(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CNR1(1), CRHR1(3), CRHR2(1), CTSG(1), CYSLTR1(1), CYSLTR2(1), DRD2(1), DRD3(1), EDNRB(1), F2(2), F2R(2), F2RL2(1), FPR1(1), FSHR(3), GABBR2(1), GABRA1(2), GABRA3(3), GABRA6(3), GABRB2(1), GABRB3(1), GABRG1(2), GABRG2(2), GABRG3(1), GABRQ(3), GABRR1(1), GALR1(2), GALR2(1), GH2(1), GHR(2), GHRHR(1), GHSR(1), GIPR(1), GLRA2(1), GLRA3(1), GPR156(1), GPR50(2), GPR63(1), GPR83(3), GRIA1(6), GRIA2(1), GRIA3(2), GRIA4(1), GRID1(5), GRID2(2), GRIK1(5), GRIK2(5), GRIK3(3), GRIK4(1), GRIK5(2), GRIN1(1), GRIN2A(9), GRIN2B(4), GRIN2C(4), GRIN2D(3), GRIN3A(4), GRM1(2), GRM2(1), GRM3(3), GRM4(1), GRM5(1), GRM6(1), GRM8(1), GRPR(1), HCRTR1(1), HCRTR2(1), HRH2(2), HRH4(1), HTR1A(1), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(3), LEPR(3), LHB(1), LHCGR(4), LTB4R2(1), MAS1(2), MC2R(1), MC3R(2), MC4R(1), MCHR2(1), NMUR1(1), NMUR2(1), NPFFR2(1), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(1), OPRK1(2), OPRM1(5), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), P2RY1(1), P2RY10(1), P2RY11(1), P2RY13(2), P2RY2(1), P2RY4(2), PARD3(3), PRLR(1), PTGDR(1), PTGER3(2), PTGFR(1), PTH2R(1), RXFP1(3), SSTR2(1), SSTR3(1), TAAR1(1), TAAR2(1), TAAR5(3), TAAR6(1), TACR2(1), THRB(1), TSHR(3)	155343279	235	160	234	83	52	79	58	20	23	3	0.0019	0.0071
164	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(1), ACTG2(2), AKT1(12), FLNA(4), FLNC(8), FSCN3(1), GDI1(3), LIMK1(3), MYH2(1), MYLK(5), PAK1(2), PAK2(1), PAK3(1), PAK7(1), RHO(2), ROCK1(1), ROCK2(2), RPS4X(1), WASF1(1), WASL(1)	33949227	53	53	43	16	8	25	9	4	7	0	0.0021	0.0078
165	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	95	ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), CAMK2A(1), CAMK2D(3), CREB3(1), CREB3L1(2), CREB3L2(2), CREB3L3(1), CREBBP(2), DCT(2), DVL3(1), EDN1(2), EDNRB(1), EP300(3), FZD1(1), FZD3(2), FZD6(2), FZD9(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(4), KIT(3), KITLG(2), KRAS(1), MAP2K1(1), MAPK1(1), MAPK3(1), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PRKACA(1), PRKCG(1), RAF1(1), TCF7(3), TCF7L2(1), TYR(3), TYRP1(2), WNT10B(1), WNT11(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT6(1), WNT7A(5), WNT8B(1), WNT9A(1)	74182719	99	85	98	39	26	34	21	4	14	0	0.0030	0.011
166	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), LPO(5), MPO(1), TPO(6)	6052566	13	13	13	0	2	5	3	0	3	0	0.0048	0.018
167	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	52	ADH1A(1), ADH7(2), ADHFE1(1), ALDH3B1(2), ALDH3B2(2), AOC2(1), AOC3(2), AOX1(3), CARM1(1), DBH(4), DCT(2), DDC(1), ECH1(1), ESCO1(3), FAH(1), GOT2(1), GSTZ1(1), HPD(1), LCMT1(1), LCMT2(3), MAOA(2), METTL2B(2), MYST3(1), MYST4(5), PNPLA3(4), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1), TPO(6), TYR(3), TYRP1(2)	42266055	67	58	67	16	10	22	16	4	12	3	0.0059	0.022
168	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	GRIN1(1), GRIN2A(9), GRIN2B(4), GRIN2C(4), GRIN2D(3), NOS1(3), PPP3CA(3), PPP3CB(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	18157191	32	31	31	7	12	5	10	2	3	0	0.0062	0.023
169	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	29	ADH1A(1), ADH7(2), ADHFE1(1), ALDH3B1(2), ALDH3B2(2), AOC2(1), AOC3(2), AOX1(3), DBH(4), DCT(2), DDC(1), FAH(1), GOT2(1), GSTZ1(1), HPD(1), MAOA(2), TPO(6), TYR(3)	21981999	36	35	36	11	4	16	7	3	6	0	0.0064	0.023
170	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(3), ADCY8(2), ARAF(1), ATF4(1), BRAF(2), CACNA1C(4), CAMK2A(1), CAMK2D(3), CREBBP(2), EP300(3), GNAQ(1), GRIA1(6), GRIA2(1), GRIN1(1), GRIN2A(9), GRIN2B(4), GRIN2C(4), GRIN2D(3), GRM1(2), GRM5(1), ITPR1(7), ITPR3(4), KRAS(1), MAP2K1(1), MAPK1(1), MAPK3(1), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PPP1R12A(1), PPP1R1A(1), PPP3CA(3), PPP3CB(2), PRKACA(1), PRKCG(1), RAF1(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3)	73788780	101	84	99	29	29	24	25	7	16	0	0.0066	0.024
171	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(1), CBR3(1), CYP4F2(1), EPX(1), GGT1(1), LPO(5), MPO(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PRDX1(1), PTGDS(1), PTGS2(1), TBXAS1(1), TPO(6)	19579833	33	31	31	1	5	11	9	3	5	0	0.0073	0.026
172	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH3B1(2), ALDH3B2(2), AOC2(1), AOC3(2), DDC(1), EPX(1), GOT2(1), HPD(1), LPO(5), MAOA(2), MPO(1), PRDX1(1), TPO(6)	15990273	26	26	26	5	4	8	4	3	7	0	0.0077	0.028
173	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), CFTR(6), GNAS(4), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(2)	8846136	18	18	18	3	5	3	5	1	4	0	0.0081	0.029
174	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CD3E(1), CD3G(1), ETV5(1), IL12A(1), IL12B(1), IL12RB1(2), IL18R1(1), JAK2(2), JUN(1), MAPK14(1), MAPK8(2), STAT4(5), TYK2(3)	13537407	22	21	21	7	3	3	7	1	8	0	0.0083	0.029
175	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(1), CD3G(1), HLA-A(4), ITGAL(1), ITGB2(3), PRF1(2)	6079437	14	14	13	5	2	6	2	0	4	0	0.0084	0.029
176	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(1)	3884127	9	9	9	0	2	5	1	0	1	0	0.0084	0.029
177	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(3), BCAT2(2), COASY(3), DPYD(1), DPYS(1), ENPP1(3), ENPP3(2), ILVBL(2), PANK2(1), PANK4(1), UPB1(3), VNN1(1)	12231882	23	23	23	5	5	5	5	4	4	0	0.0088	0.031
178	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	25	ADRBK1(1), AKT1(12), AKT2(1), AKT3(2), GNAQ(1), ITPKB(7), ITPR1(7), ITPR3(4), NFKB1(1), NFKB2(4), PDK1(1), PHKA2(4), PIK3CB(3), PITX2(1), PLD1(1), PLD3(1)	32230497	51	44	41	12	7	22	5	5	9	3	0.010	0.036
179	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ACPP(1), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(1), CYP2C9(2), CYP2D6(2), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(2), CYP4F8(2), PON1(1)	21563217	41	36	40	8	7	12	11	4	7	0	0.011	0.036
180	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(3), AMY2A(1), ENPP1(3), ENPP3(2), GAA(2), GBE1(3), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(1), HK1(1), HK3(2), MGAM(8), PGM1(1), PGM3(1), PYGB(3), PYGL(1), PYGM(2), RNPC3(1), SI(4), UCHL3(1), UGT1A10(1), UGT1A6(2), UGT2B15(2), UGT2B4(1), UXS1(2)	41250534	58	54	58	16	11	15	16	6	10	0	0.011	0.038
181	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(1), CD3E(1), CD3G(1), CD4(1), CD8A(1), IL6(2), KITLG(2)	4662879	11	11	11	2	1	4	3	0	3	0	0.012	0.041
182	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(12), GRB2(1), IL2RG(1), IRS1(1), JAK1(1), JAK3(1), SHC1(1)	11087076	18	18	8	4	0	13	2	1	2	0	0.012	0.041
183	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3), GNAS(4), GNB1(1), PRKACA(1), PRKAR1A(1)	4388085	10	10	10	3	3	2	3	1	1	0	0.012	0.042
184	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	AKR1B1(2), B4GALT1(2), G6PC2(1), GAA(2), GALT(1), GANC(1), GCK(2), GLA(2), GLB1(1), HK1(1), HK3(2), LCT(3), MGAM(8), PFKM(3), PFKP(2), PGM1(1), PGM3(1), RDH11(2), RDH12(1), RDH14(1)	26363493	39	38	39	10	5	13	10	5	6	0	0.013	0.044
185	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	28	AKT1(12), AKT2(1), AKT3(2), ANKRD6(4), APC(3), AXIN1(1), CER1(1), DKK4(1), GSK3A(1), LRP1(7), MVP(1), NKD1(1), PTPRA(1), SFRP1(2), WIF1(1)	28312908	39	38	29	11	8	17	6	3	5	0	0.013	0.045
186	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(8), BAIAP2(1), CASP1(1), CASP8(2), INSR(2), MAGI1(3), MAGI2(6), RERE(1), WWP2(4)	17024046	28	25	26	7	6	9	4	1	8	0	0.014	0.046
187	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(1), BRAF(2), C7orf16(1), CACNA1A(5), CRHR1(3), GNAI1(1), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(4), GRIA1(6), GRIA2(1), GRIA3(2), GRID2(2), GRM1(2), GRM5(1), GUCY1A2(2), GUCY2C(5), GUCY2D(1), GUCY2F(2), IGF1(1), IGF1R(1), ITPR1(7), ITPR3(4), KRAS(1), LYN(3), MAP2K1(1), MAPK1(1), MAPK3(1), NOS1(3), NOS3(2), NPR1(1), NPR2(2), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PPP2CB(2), PRKCG(1), PRKG1(1), PRKG2(4), RAF1(1), RYR1(5)	80529852	111	96	108	24	33	34	22	9	13	0	0.014	0.047
188	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(3), COASY(3), DPYD(1), DPYS(1), ENPP1(3), ENPP3(2), PANK2(1), PANK4(1), UPB1(3)	9672546	18	18	18	3	3	2	5	4	4	0	0.015	0.048
189	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(3), AR(3), ESR1(2), ESR2(2), HNF4A(2), NR1D1(1), NR1D2(1), NR1H2(3), NR2E1(1), NR4A1(1), NR4A2(1), NR5A2(4), PGR(2), PPARA(1), PPARG(1), RARA(1), RARB(4), RARG(2), ROR1(6), RORC(2), THRB(1)	29827317	44	42	44	16	12	14	6	0	10	2	0.015	0.049
190	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CD2(2), CD3E(1), CD3G(1), CD4(1), IL12A(1), IL12B(1), IL12RB1(2), JAK2(2), STAT4(5), TYK2(3)	10578555	19	18	18	5	3	2	7	1	6	0	0.018	0.057
191	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(2), EPOR(1), GRB2(1), JAK2(2), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PLCG1(4), RAF1(1), SHC1(1), SOS1(3), STAT5B(4)	15806232	25	24	25	2	2	10	4	1	8	0	0.018	0.059
192	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	63	ATP8A1(2), AVPR1B(1), BDKRB1(2), BRS3(1), CCR2(4), CCR3(1), CCR7(2), CX3CR1(2), EDNRB(1), FPR1(1), FSHR(3), GALR1(2), GALR2(1), GALT(1), GHSR(1), GPR77(2), GRPR(1), LHCGR(4), MC2R(1), MC3R(2), MC4R(1), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(1), OPRK1(2), OPRM1(5), SSTR2(1), SSTR3(1), TACR2(1), TSHR(3)	36079134	55	51	55	22	5	25	11	7	7	0	0.019	0.059
193	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ACTG2(2), ADCY3(2), ADCY9(5), ARF1(1), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), ERO1L(2), GNAS(4), PDIA4(2), PLCG1(4), PLCG2(2), SEC61A1(1), TRIM23(2)	26759460	37	35	37	5	5	10	10	5	7	0	0.020	0.065
194	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), CD38(2), ENPP1(3), ENPP3(2), NMNAT1(1), NMNAT2(1), NNT(4), NT5E(3)	10647507	19	19	19	2	2	3	10	3	1	0	0.021	0.067
195	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), DDX20(2), E2F1(2), E2F4(2), ETS1(2), ETS2(3), ETV3(1), HDAC2(2), JUN(1), NCOR2(3), RBL1(1), RBL2(1), SIN3A(2), SIN3B(2)	17046354	26	26	26	9	6	5	7	2	6	0	0.021	0.068
196	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	148	ADORA1(1), ADORA3(1), ADRA1A(1), ADRA1B(1), AVPR1B(1), BDKRB1(2), BRS3(1), CCR2(4), CCR3(1), CCR7(2), CCRL1(1), CHML(2), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CMKLR1(1), CNR1(1), CX3CR1(2), DRD2(1), DRD3(1), EDNRB(1), F2R(2), F2RL2(1), FPR1(1), FSHR(3), GALR1(2), GALR2(1), GALT(1), GHSR(1), GPR37(2), GPR50(2), GPR6(1), GPR63(1), GPR77(2), GPR83(3), GRPR(1), HCRTR1(1), HCRTR2(1), HRH2(2), HTR1A(1), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(3), LHCGR(4), MAS1(2), MC3R(2), MC4R(1), NMUR1(1), NMUR2(1), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(1), OPRK1(2), OPRM1(5), OR12D3(4), OR7A5(1), P2RY1(1), P2RY10(1), P2RY11(1), P2RY13(2), P2RY2(1), PTGDR(1), PTGFR(1), RHO(2), SSTR2(1), SSTR3(1)	82767243	114	97	113	41	18	43	25	11	17	0	0.022	0.068
197	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3), CREM(1), FHL5(1), FSHR(3), GNAS(4), XPO1(2)	6646770	14	14	14	1	3	4	4	1	2	0	0.022	0.068
198	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	47	ACHE(2), AGPAT3(2), AGPS(1), CDS1(2), CLC(1), DGKA(3), DGKD(1), DGKE(1), DGKG(4), DGKH(1), ETNK1(3), GNPAT(1), GPD1(2), GPD2(1), LCAT(1), PAFAH1B1(1), PCYT1A(1), PCYT1B(2), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLCB2(2), PLCG1(4), PLCG2(2), PPAP2A(1)	34307169	50	46	47	9	7	17	11	9	6	0	0.022	0.070
199	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	EPX(1), LPO(5), MPO(1), PRDX1(1), TPO(6)	8287929	14	14	14	1	2	5	3	0	4	0	0.024	0.074
200	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(3), ELK1(2), GNAI1(1), GNAQ(1), GNAS(4), GNB1(1), JUN(1), MAP2K1(1), MAPK3(1), NFATC3(3), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CB(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAF1(1), RPS6KA3(2)	24281244	36	34	36	6	8	9	13	1	5	0	0.024	0.074
201	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), ADRA1A(1), ADRA1B(1), ANXA6(1), ARRB1(1), ATP1A4(5), ATP1B1(1), ATP2B1(4), ATP2B2(4), ATP2B3(4), CACNA1A(5), CACNA1B(1), CACNA1C(4), CACNA1D(4), CACNA1E(8), CACNA1S(1), CACNB1(1), CALR(1), CAMK1(1), CAMK2A(1), CAMK2D(3), CASQ2(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), GJA1(2), GJA4(1), GJB2(1), GJB3(2), GJB4(1), GJB5(1), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB3(2), GRK4(3), GRK6(1), ITPR1(7), ITPR3(4), KCNJ3(1), MIB1(2), NME7(2), PKIG(1), PLCB3(1), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), PRKD1(1), RGS1(1), RGS14(1), RGS17(2), RGS20(1), RGS3(2), RGS4(3), RGS5(1), RGS7(5), RGS9(2), RYR1(5), RYR2(13), RYR3(11), USP5(4), YWHAB(1)	139403706	175	130	175	79	43	52	44	8	24	4	0.025	0.075
202	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD2(2), CD33(1), CD5(2), IFNB1(1), IL12A(1), IL12B(1), ITGAX(2), TLR2(1), TLR4(7), TLR7(3)	14010945	24	21	23	7	5	6	4	1	8	0	0.025	0.077
203	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	ALDOB(2), ENO1(1), GPI(2), HK1(1), PGK1(2)	5463939	8	8	8	0	1	3	2	0	2	0	0.027	0.082
204	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), CHST1(1), CHST2(3), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	8156109	13	13	13	1	3	6	0	1	3	0	0.028	0.085
205	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ACTA2(1), ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), ARRB1(1), ATF3(1), ATF4(1), ATF5(2), CALCA(1), CAMK2A(1), CAMK2D(3), CORIN(1), CREB3(1), CRHR1(3), ETS2(3), GABPA(1), GJA1(2), GNAQ(1), GNB1(1), GNB3(2), GRK4(3), GRK6(1), IGFBP3(1), IL6(2), ITPR1(7), ITPR3(4), JUN(1), MIB1(2), NFKB1(1), NOS1(3), NOS3(2), PDE4B(2), PDE4D(3), PKIG(1), PLCB3(1), PLCD1(1), PLCG1(4), PLCG2(2), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCH(1), PRKCQ(2), PRKCZ(1), PRKD1(1), RAMP3(1), RGS1(1), RGS14(1), RGS17(2), RGS20(1), RGS3(2), RGS4(3), RGS5(1), RGS7(5), RGS9(2), RLN1(1), RYR1(5), RYR2(13), RYR3(11), SP1(1), TNXB(3), USP5(4), YWHAB(1)	127673754	151	122	151	64	35	43	42	6	25	0	0.029	0.087
206	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(3), ALDOB(2), G6PD(1), GPI(2), H6PD(2), PFKM(3), PFKP(2), PGD(2), PGLS(2), PGM1(1), PGM3(1), PRPS2(1), TKT(1)	14669031	23	23	23	4	7	5	3	4	4	0	0.029	0.087
207	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	64	A2M(3), BDKRB1(2), C2(1), C3(2), C4BPA(1), C4BPB(1), C5(3), C6(4), C7(3), C9(1), CD55(2), CFB(1), CFH(4), CPB2(1), CR1(6), CR2(2), F12(1), F13A1(3), F2(2), F2R(2), F5(7), F8(1), FGA(3), KLKB1(1), KNG1(1), MASP1(1), MASP2(1), MBL2(1), PLAT(1), PLAU(2), PLG(2), PROC(1), SERPINA1(1), SERPINA5(3), SERPINC1(2), SERPIND1(1), SERPINE1(1), TFPI(1), VWF(6)	66437787	82	75	81	25	11	27	21	12	11	0	0.029	0.087
208	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ALDH3B1(2), ALDH3B2(2), AOC2(1), AOC3(2), DDC(1), EPX(1), ESCO1(3), GOT2(1), HPD(1), LPO(5), MAOA(2), MPO(1), MYST3(1), MYST4(5), PNPLA3(4), TPO(6)	25210575	38	35	38	7	8	10	6	4	7	3	0.032	0.094
209	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(2), EGFR(4), ERBB3(8)	7630857	14	14	14	2	1	2	2	8	1	0	0.033	0.098
210	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	5	GNAQ(1), ITPKB(7)	3916575	8	8	8	0	1	2	0	3	2	0	0.035	0.10
211	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), GAA(2), GALT(1), GCK(2), GLA(2), GLB1(1), HK1(1), HK3(2), LCT(3), MGAM(8), PFKM(3), PFKP(2), PGM1(1), PGM3(1)	22943778	33	32	33	10	5	11	7	5	5	0	0.036	0.11
212	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(3), CALCR(1), CALCRL(1), CD97(5), CRHR1(3), CRHR2(1), ELTD1(2), EMR1(2), EMR2(3), GHRHR(1), GIPR(1), GPR64(3), LPHN1(2), LPHN2(3), LPHN3(4)	19996080	35	31	35	10	4	8	10	4	6	3	0.036	0.11
213	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	EGFR(4), ELK1(2), GNAS(4), GNB1(1), GRB2(1), IGF1R(1), ITGB1(2), KLK2(2), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), NGFR(1), PDGFRA(3), PTPRR(1), RAF1(1), RPS6KA1(1), SHC1(1), SOS1(3), STAT3(1)	23317944	33	33	33	6	4	13	9	4	3	0	0.038	0.11
214	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(3), ALDOB(2), G6PD(1), GPI(2), H6PD(2), PFKM(3), PFKP(2), PGD(2), PGLS(2), PGM1(1), PGM3(1), PRPS2(1), TKT(1), TKTL1(1), TKTL2(1)	16685877	25	25	25	4	7	6	4	4	4	0	0.039	0.11
215	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	27	ADRA1A(1), ADRA1B(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), DRD2(1), DRD3(1), HRH2(2), HTR1A(1), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(3)	16994640	26	25	26	10	9	8	3	0	6	0	0.040	0.11
216	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), DRD2(1), EGF(2), EGFR(4), GJA1(2), GNAI1(1), GNAI2(1), GNAQ(1), GNAS(4), GRB2(1), GRM1(2), GRM5(1), GUCY1A2(2), GUCY2C(5), GUCY2D(1), GUCY2F(2), HTR2A(3), HTR2B(1), HTR2C(1), ITPR1(7), ITPR3(4), KRAS(1), MAP2K1(1), MAP2K5(1), MAPK1(1), MAPK3(1), NPR1(1), NPR2(2), PDGFB(1), PDGFRA(3), PDGFRB(2), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PRKACA(1), PRKCG(1), PRKG1(1), PRKG2(4), RAF1(1), SOS1(3), SOS2(1), TJP1(4), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2B(1), TUBB2C(2), TUBB4(1)	95638452	114	93	113	36	26	41	20	10	17	0	0.041	0.12
217	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	AGXT(1), AGXT2(1), ALAS2(1), AMT(1), AOC2(1), AOC3(2), BHMT(1), CBS(1), CTH(1), DAO(1), DLD(1), DMGDH(3), GARS(1), GATM(3), GCAT(2), MAOA(2), PLCB2(2), PLCG1(4), PLCG2(2), SARDH(2), SARS(2), TARS(4)	29933280	39	37	39	17	7	16	6	2	8	0	0.043	0.12
218	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	35	ACTA2(1), ACTN2(4), ACTN3(1), ACTN4(4), DMD(11), MYBPC1(2), MYBPC2(1), MYBPC3(1), MYH3(1), MYH6(7), MYH7(6), MYH8(4), MYL1(1), MYOM1(2), NEB(13), TMOD1(1), TNNC2(1), TNNI3(1), TPM1(2), TPM2(1), TPM3(1), TTN(77)	104159094	143	112	143	25	26	35	45	13	20	4	0.044	0.13
219	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR1(2), ESR2(2), PDE1A(2), PDE1B(1), PLCB1(3), PLCB2(2), VIP(1)	7870668	13	13	13	2	9	2	1	0	1	0	0.046	0.13
220	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(1), LPO(5), MPO(1), TPO(6)	8250918	13	13	13	1	2	5	3	0	3	0	0.048	0.14
221	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(3), CAMK2A(1), CAMK2D(3), CDK5(1), F2(2), GNAI1(1), GNB1(1), GRB2(1), JAK2(2), MAP2K1(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPT(1), MYLK(5), PLCG1(4), PTK2B(3), RAF1(1), SHC1(1), SOS1(3), STAT1(1), STAT3(1)	30070170	41	39	41	11	6	17	8	2	8	0	0.050	0.14
222	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(3), ALDOB(2), GCK(2), GMDS(2), HK1(1), HK3(2), KHK(1), PFKFB1(1), PFKFB3(1), PFKFB4(1), PFKM(3), PFKP(2)	17381988	23	23	23	4	4	11	2	2	4	0	0.050	0.14
223	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	CYP2C18(2), CYP2C19(1), CYP2C8(1), CYP2C9(2), CYP3A4(3), CYP3A7(4), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), RDH11(2), RDH12(1), RDH14(1)	17358159	30	27	28	6	5	8	7	4	6	0	0.054	0.15
224	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(1), ACP6(1), ACPP(1), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP3A4(3), CYP3A7(4), DHRS2(2), DHRS7(1), PON1(1), PON3(1)	12883377	25	20	24	6	6	6	6	3	4	0	0.058	0.16
225	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), CD38(2), ENPP1(3), ENPP3(2), NADK(1), NMNAT1(1), NMNAT2(1), NNT(4), NT5C1B(3), NT5C3(1), NT5E(3)	15745899	24	24	24	3	4	4	12	3	1	0	0.059	0.16
226	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(3), F2(2), F2R(2), FGA(3), PLAT(1), PLAU(2), PLG(2), SERPINE1(1)	10074597	17	17	17	5	3	7	3	3	1	0	0.059	0.16
227	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), CHPT1(1), LCMT1(1), LCMT2(3), METTL2B(2), PCYT1A(1), PCYT1B(2), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1)	10125297	19	16	19	3	2	6	6	1	4	0	0.063	0.17
228	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(4), PTK2B(3)	5011695	8	8	8	0	3	2	1	0	2	0	0.065	0.17
229	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), AGT(3), EDN1(2), EDNRB(1), EGF(2), EGFR(4), JUN(1), MYC(1), NFKB1(1), PLCG1(4), RELA(1)	15368184	21	21	21	4	5	6	1	5	4	0	0.065	0.17
230	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(2), BMP4(2), BMP5(1), BMP6(1), BMP8B(1), CSNK1A1L(2), CSNK1E(1), DHH(1), GLI1(2), GLI2(2), GLI3(3), LRP2(17), PRKACA(1), PTCH1(3), SMO(2), SUFU(2), WNT10B(1), WNT11(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT6(1), WNT7A(5), WNT8B(1), WNT9A(1), ZIC2(1)	42390270	58	52	58	23	13	21	10	8	6	0	0.065	0.17
231	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(1), DHRS2(2), DHRS7(1), LCMT1(1), LCMT2(3), METTL2B(2), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1)	10633311	18	16	18	4	3	4	6	1	4	0	0.066	0.18
232	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(1), CD4(1), HLA-DRB1(2), IL5RA(1), IL6(2)	4083885	8	8	8	3	0	3	1	1	3	0	0.068	0.18
233	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), GCH1(1)	4283643	9	8	8	2	2	2	3	1	1	0	0.071	0.19
234	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(3), GNAS(4), PLCE1(5), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAP2B(1)	10122762	16	16	16	4	5	4	3	1	3	0	0.071	0.19
235	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	37	CREBBP(2), DTX1(3), DTX2(1), DTX4(1), DVL3(1), EP300(3), HDAC1(2), HDAC2(2), JAG1(1), MAML1(1), MAML2(1), MAML3(1), NCOR2(3), NCSTN(1), NOTCH2(4), NOTCH3(3), NOTCH4(6), NUMB(1), NUMBL(3), PSEN2(2), PTCRA(1), RBPJL(3), SNW1(2)	42009006	48	43	46	17	11	12	9	2	12	2	0.072	0.19
236	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(1), GNB1(1), HTR2C(1), PLCB1(3), TUB(2)	5256069	10	10	10	1	4	4	2	0	0	0	0.073	0.19
237	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	86	AKT1(12), AKT3(2), CAPN1(3), CAPN10(1), CAPN11(1), CAPN2(2), CAPN6(1), CAV1(1), GRB2(1), ILK(2), ITGA10(1), ITGA11(4), ITGA2(2), ITGA2B(2), ITGA4(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGAD(1), ITGAL(1), ITGAM(1), ITGAV(3), ITGAX(2), ITGB1(2), ITGB2(3), ITGB3(2), ITGB4(4), ITGB5(2), ITGB8(1), MAP2K1(1), MAP2K3(1), MAPK10(1), MAPK4(2), MAPK6(1), PAK1(2), PAK2(1), PAK3(1), PTK2(1), PXN(1), RAPGEF1(3), RHO(2), ROCK1(1), ROCK2(2), SDCCAG8(3), SHC1(1), SHC3(1), SORBS1(4), SOS1(3), TLN1(7), TNS1(4), VAV3(1), VCL(3)	96464862	115	94	105	35	21	36	27	9	22	0	0.075	0.19
238	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACAA1(1), ACOX1(2), ACOX3(1), ELOVL5(2), ELOVL6(2), FADS2(4), SCD(1)	7883850	13	13	13	4	0	3	4	4	2	0	0.075	0.20
239	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	48	ADORA3(1), ALG6(1), CCR2(4), CCR3(1), CELSR2(1), CELSR3(4), CHRM2(2), CHRM3(1), EMR2(3), EMR3(2), F2R(2), FSHR(3), GHRHR(1), GPR132(1), GPR133(1), GPR143(2), GPR56(1), GPR77(2), GPR84(2), GRM1(2), GRPR(1), HRH4(1), LGR6(2), LPHN2(3), LPHN3(4), LTB4R2(1), P2RY11(1), P2RY13(2), PTGFR(1), SMO(2), SSTR2(1), TAAR5(3), TSHR(3)	43026048	62	55	62	13	12	25	14	5	6	0	0.080	0.21
240	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(3), CAPN2(2), EGF(2), EGFR(4), ITGA1(3), ITGB1(2), MAPK1(1), MAPK3(1), MYLK(5), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTK2(1), PXN(1), TLN1(7)	24248796	35	33	35	12	5	13	6	8	3	0	0.083	0.21
241	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	33	ACTN2(4), ACTN3(1), BCR(1), CAPN1(3), CAV1(1), CRKL(1), GRB2(1), ITGA1(3), ITGB1(2), JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(2), PTK2(1), PXN(1), RAF1(1), ROCK1(1), SHC1(1), SOS1(3), TLN1(7), VCL(3)	32807463	41	40	41	12	3	13	13	2	10	0	0.084	0.22
242	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	61	ACHE(2), AGPAT3(2), AGPAT6(1), CDS1(2), CHPT1(1), DGKA(3), DGKD(1), DGKE(1), DGKG(4), DGKH(1), DGKI(5), ESCO1(3), ETNK1(3), ETNK2(1), GNPAT(1), GPD1(2), GPD1L(1), GPD2(1), LCAT(1), MYST3(1), MYST4(5), PCYT1A(1), PCYT1B(2), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLD1(1), PNPLA3(4), PPAP2A(1), PTDSS2(1)	45749145	65	57	62	13	12	20	13	10	7	3	0.086	0.22
243	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(1), IDI1(2), SQLE(1)	2398617	5	5	5	3	2	2	0	0	1	0	0.087	0.22
244	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(3), CSF1(2), IL6R(1), SELL(4), SPN(2), TNFRSF1A(1), TNFRSF8(1)	9757722	14	14	13	4	4	2	3	2	3	0	0.10	0.25
245	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(1), ACOX1(2), ACOX3(1), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(2), APOA5(1), AQP7(2), CD36(1), CPT1A(2), CPT1C(2), CPT2(1), CYP27A1(1), CYP8B1(1), EHHADH(2), FABP1(1), FABP2(1), FABP4(1), FABP6(1), FADS2(4), GK2(1), HMGCS2(1), ILK(2), LPL(1), PCK1(1), PCK2(1), PLTP(1), PPARA(1), PPARG(1), SCD(1), SLC27A2(1), SLC27A4(2), SLC27A5(2), SORBS1(4), UBC(6)	47968791	56	52	56	18	8	15	14	5	14	0	0.10	0.26
246	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(1), CYP11B1(2), CYP11B2(3), CYP17A1(1), CYP21A2(2), HSD3B2(2)	6722313	12	12	12	1	4	3	4	1	0	0	0.10	0.26
247	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(1), CYP11B1(2), CYP11B2(3), CYP17A1(1), CYP21A2(2), HSD3B2(2)	6722313	12	12	12	1	4	3	4	1	0	0	0.10	0.26
248	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT2(2), FUT3(2), ST3GAL3(1)	3254940	5	5	4	0	3	0	0	0	2	0	0.11	0.26
249	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	AGXT(1), AGXT2(1), ALAS2(1), AMT(1), AOC2(1), AOC3(2), BHMT(1), CBS(1), CTH(1), DAO(1), DLD(1), DMGDH(3), GARS(1), GATM(3), GCAT(2), MAOA(2), PIPOX(1), RDH11(2), RDH12(1), RDH14(1), SARDH(2), SARS(2), SARS2(2), TARS(4), TARS2(2)	30761211	40	38	40	20	7	16	8	2	7	0	0.11	0.26
250	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ACPP(1), ACPT(2), ENPP1(3), ENPP3(2), TYR(3)	7215117	12	12	12	4	2	4	3	2	1	0	0.11	0.26
251	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	103	ALG1(1), ALG10(1), ALG10B(3), ALG11(1), ALG13(2), ALG2(1), ALG6(1), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), C1GALT1(1), C1GALT1C1(1), CHPF(1), CHST1(1), CHST11(1), CHST2(3), CHST3(1), DPAGT1(2), EXT1(3), EXT2(2), EXTL3(3), FUT11(1), GALNT10(2), GALNT11(3), GALNT13(1), GALNT3(1), GALNT4(1), GALNT5(2), GALNT7(2), GALNTL1(1), GALNTL5(1), GCNT4(1), HS2ST1(1), HS3ST2(1), HS3ST5(3), HS6ST2(3), HS6ST3(1), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT3(1), MGAT5(2), MGAT5B(4), NDST3(1), OGT(2), RPN1(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(2), UST(1), WBSCR17(4), XYLT2(1)	78611871	88	79	88	39	22	25	17	6	18	0	0.11	0.27
252	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(3), AMY2A(1), ASCC3(1), ATP13A2(1), DDX41(1), DDX50(3), DDX55(3), DDX56(1), DHX58(2), ENPP1(3), ENPP3(2), ENTPD7(1), ERCC3(2), G6PC2(1), GAA(2), GANC(1), GBE1(3), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(1), HK1(1), HK3(2), IFIH1(1), MGAM(8), NUDT8(1), PGM1(1), PGM3(1), PYGB(3), PYGL(1), PYGM(2), RAD54B(4), RAD54L(2), SETX(6), SI(4), SKIV2L2(1), SMARCA2(3), SMARCA5(1), TREH(1), UGT1A10(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B15(2), UGT2B28(1), UGT2B4(1), UXS1(2)	89551410	97	86	97	21	20	24	27	10	16	0	0.11	0.28
253	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	CDK5(1), EGR1(1), KLK2(2), MAP2K1(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1)	5585112	9	9	9	2	0	5	2	1	1	0	0.11	0.28
254	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	13	ACHE(2), DBH(4), DDC(1), GAD1(2), GAD2(3), MAOA(2), PAH(1)	9864699	15	15	15	1	3	5	5	0	2	0	0.12	0.28
255	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT5(1), FUT2(2), FUT3(2), ST3GAL3(1), ST3GAL4(1)	5462925	8	8	7	0	3	2	1	0	2	0	0.12	0.28
256	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), B3GALT5(1), FUT2(2), GLA(2), HEXB(1), ST3GAL1(1), ST8SIA1(1)	7540104	9	9	8	1	2	0	3	1	3	0	0.12	0.28
257	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(2), F2R(2), F5(7), FGA(3), PROC(1), SERPINC1(2), TFPI(1)	11751246	18	18	18	6	2	6	2	5	3	0	0.12	0.29
258	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(2), GALNT3(1), GALNT4(1), GALNT7(2), ST3GAL1(1), ST3GAL4(1), WBSCR17(4)	10584639	12	12	12	6	2	3	2	0	5	0	0.12	0.29
259	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(3)	1383603	3	3	3	1	1	1	0	0	1	0	0.12	0.29
260	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), AKAP1(1), AKAP11(5), AKAP12(2), AKAP3(2), AKAP6(3), AKAP8(1), AKAP9(7), ARHGEF1(5), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB3(2), ITPR1(7), KCNJ3(1), KRAS(1), PDE1A(2), PDE1B(1), PDE4A(1), PDE4B(2), PDE4C(3), PDE4D(3), PLCB3(1), PPP3CA(3), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKCZ(1), PRKD1(1), RHOA(2), USP5(4)	85302243	91	81	91	36	22	23	25	8	13	0	0.13	0.30
261	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1), CD3G(1)	864942	2	2	2	0	0	1	1	0	0	0	0.13	0.30
262	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(2), C5(3), C6(4), C7(3), IL1A(1), IL6(2), ITGA4(1), ITGAL(1), ITGB1(2), ITGB2(3), SELP(3), SELPLG(1), VCAM1(2)	17954898	28	25	28	6	8	5	6	4	5	0	0.13	0.31
263	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(1), HLA-DRB1(2)	2298231	4	4	4	1	0	1	1	1	1	0	0.13	0.31
264	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(3), IARS(5), LARS2(2), PDHA1(1), PDHA2(1), PDHB(1)	7556328	13	12	13	4	2	5	4	0	2	0	0.13	0.31
265	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	549588	1	1	1	1	0	0	0	0	1	0	0.13	0.31
266	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F12(1), F2(2), F5(7), F8(1), FGA(3), LPA(5), PLAT(1), PLAU(2), PLG(2), SERPINE1(1), VWF(6)	25646088	31	31	30	12	3	12	7	5	4	0	0.13	0.31
267	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	20	ABAT(3), ADSL(1), AGXT(1), AGXT2(1), ASL(3), ASPA(1), CAD(7), CRAT(3), DARS(1), GAD1(2), GAD2(3), GOT2(1), GPT2(2), NARS(1), PC(1)	18343767	31	28	31	4	7	13	5	3	3	0	0.14	0.31
268	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CDO1(1), GAD1(2), GAD2(3), GGT1(1)	4305951	8	8	8	0	2	3	3	0	0	0	0.14	0.31
269	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT2(2), GLA(2), HEXB(1), ST3GAL1(1), ST3GAL4(1), ST8SIA1(1)	7070115	8	8	7	1	2	1	2	0	3	0	0.14	0.32
270	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(2), ALDOA(3), ALDOB(2), FUK(2), GMDS(2), HK1(1), HK3(2), KHK(1), MTMR6(1), PFKFB1(1), PFKFB3(1), PFKFB4(1), PFKM(3), PFKP(2), RDH11(2), RDH12(1), RDH14(1)	25502100	28	27	28	8	4	11	4	3	6	0	0.14	0.33
271	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12A(1), IL12B(1), IL2(1)	2321046	4	4	4	1	0	0	2	1	1	0	0.14	0.33
272	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	16	GNAQ(1), JUN(1), MAPK14(1), MAPK8(2), PLCG1(4), PTK2B(3)	9682686	12	12	12	2	3	4	1	0	4	0	0.16	0.36
273	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), GNAS(4), GNB1(1), PRKAA2(2), PRKAB1(1), PRKAG2(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	10483239	15	15	15	6	6	3	3	1	2	0	0.16	0.36
274	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	12	ECHS1(1), EHHADH(2), HADH(1), HSD17B10(1), HSD17B4(3), NTAN1(1), VNN2(3)	8264100	12	12	12	5	2	2	6	1	1	0	0.16	0.36
275	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(1), ELK1(2), GRB2(1), IL6(2), IL6R(1), IL6ST(3), JAK1(1), JAK2(2), JAK3(1), JUN(1), MAP2K1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(3), SRF(1), STAT3(1)	17464629	24	23	24	3	1	6	7	3	7	0	0.16	0.36
276	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(1), HADH(1), HADHB(1), HSD17B10(1), HSD17B4(3), PPT2(1)	6138756	9	9	9	3	3	2	1	2	1	0	0.16	0.36
277	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(3), EDN1(2), EP300(3), JUN(1), NOS3(2)	11883066	13	13	12	4	4	1	1	1	6	0	0.17	0.37
278	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	30	ABAT(3), ADC(1), ALDH5A1(1), CAD(7), CPS1(2), EARS2(3), EPRS(2), GAD1(2), GAD2(3), GCLC(1), GCLM(1), GFPT2(3), GLS(1), GLUD2(1), GMPS(1), GNPNAT1(1), GOT2(1), GPT2(2), GSS(1), NAGK(1), PPAT(1), QARS(2)	28367664	41	37	41	5	7	11	17	3	3	0	0.17	0.38
279	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(6), CR2(2), HLA-DRB1(2), ITGAL(1), ITGB2(3), PTPRC(1)	11272638	15	15	15	7	3	2	5	4	1	0	0.17	0.38
280	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(2), C5(3), C6(4), C7(3), C9(1)	9174165	13	13	13	3	2	4	3	2	2	0	0.17	0.38
281	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(8), CARM1(1), CCND1(1), CREBBP(2), EP300(3), ERCC3(2), ESR1(2), HDAC1(2), HDAC2(2), HDAC3(1), HDAC6(2), MEF2C(2), NCOR2(3), POLR2A(2), TBP(1)	32082453	34	32	33	9	7	5	7	1	14	0	0.18	0.38
282	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ITGA4(1), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(3), SELE(1), SELL(4), SELP(3)	12912783	16	16	16	2	4	1	5	3	3	0	0.18	0.38
283	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	GNAQ(1), NFATC3(3), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CB(2), SP1(1), SP3(3)	14787669	20	18	20	3	2	4	9	0	5	0	0.18	0.39
284	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(1), SNAP25(1)	2437656	4	4	4	1	1	1	1	1	0	0	0.18	0.39
285	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(2), LRP8(1), RELN(10), VLDLR(2)	10596300	16	16	15	3	4	5	4	0	3	0	0.18	0.39
286	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT3(2), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH1B3(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLD1(1), PPAP2A(1)	16270137	25	23	23	3	5	6	7	5	2	0	0.19	0.40
287	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN2(4), ACTN3(1), CAPN1(3), ITGA1(3), ITGB1(2), ITGB3(2), PTK2(1), PXN(1), SPTAN1(2), TLN1(7)	21083595	26	26	26	8	2	9	9	2	4	0	0.19	0.40
288	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(2), GABRA3(3), GABRA6(3), SOD1(1)	5944068	9	9	9	4	2	5	2	0	0	0	0.19	0.40
289	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	9	ANPEP(3), FBL(2), LDHC(1), MAPK14(1), NCL(1)	6315699	8	8	8	1	2	4	1	0	1	0	0.19	0.41
290	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(2), B4GALT3(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	5528328	7	7	7	0	2	2	0	1	2	0	0.19	0.41
291	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH7(2), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH3B1(2), ALDH3B2(2), ALDH9A1(1), ALDOA(3), ALDOB(2), DLD(1), ENO1(1), ENO3(1), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(3), PFKP(2), PGK1(2), PGM1(1), PGM3(1)	35244612	42	39	42	10	6	21	5	7	3	0	0.19	0.41
292	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH7(2), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH3B1(2), ALDH3B2(2), ALDH9A1(1), ALDOA(3), ALDOB(2), DLD(1), ENO1(1), ENO3(1), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(3), PFKP(2), PGK1(2), PGM1(1), PGM3(1)	35244612	42	39	42	10	6	21	5	7	3	0	0.19	0.41
293	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(2), IL6(2), LDLR(1), LPL(1)	3979443	7	7	7	5	2	2	1	0	2	0	0.19	0.41
294	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	18	B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(1), FUT2(2), FUT3(2), ST3GAL6(1), ST8SIA1(1)	10440651	13	13	12	2	6	1	1	2	3	0	0.19	0.41
295	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(1), CAMK1G(1), CAMK2A(1), CAMK2D(3), CAMKK1(3), CAMKK2(2)	8115042	11	11	11	5	2	2	4	0	3	0	0.20	0.41
296	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(2), F2R(2), GNAI1(1), GNB1(1), ITGA1(3), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), PLA2G4A(6), PLCB1(3), PTK2(1), RAF1(1), TBXAS1(1)	17665908	26	24	25	5	5	10	7	4	0	0	0.20	0.41
297	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(3), CAP1(2), CCNB1(2), GNAI1(1), GNAS(4), GNB1(1), MAPK1(1), MAPK3(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1)	13810173	19	18	19	5	5	6	4	2	2	0	0.20	0.41
298	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	122	ABL1(2), ARHGEF12(2), CDK5(1), DCC(6), DPYSL2(1), DPYSL5(1), EFNA3(1), EFNB1(1), EFNB2(1), EPHA1(2), EPHA2(2), EPHA3(2), EPHA4(1), EPHA5(5), EPHA6(2), EPHA7(2), EPHB1(2), EPHB2(1), EPHB3(1), EPHB4(1), EPHB6(2), FES(1), GNAI1(1), GNAI2(1), ITGB1(2), KRAS(1), L1CAM(1), LIMK1(3), LIMK2(1), MAPK1(1), MAPK3(1), MET(4), NFAT5(1), NFATC3(3), NFATC4(3), NGEF(2), NRP1(3), NTNG1(2), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PLXNA1(3), PLXNA2(4), PLXNA3(3), PLXNB1(1), PLXNC1(1), PPP3CA(3), PPP3CB(2), PTK2(1), RASA1(2), RGS3(2), RHOA(2), ROBO1(2), ROBO2(3), ROCK1(1), ROCK2(2), SEMA3A(2), SEMA3B(1), SEMA3C(1), SEMA3D(1), SEMA3E(1), SEMA3F(1), SEMA4A(1), SEMA4F(5), SEMA4G(1), SEMA5A(3), SEMA5B(2), SEMA6A(1), SEMA7A(1), SLIT1(1), SLIT2(2), SLIT3(1), SRGAP1(5), SRGAP3(1), UNC5B(1), UNC5C(3), UNC5D(6)	136224816	148	120	148	44	34	47	33	8	23	3	0.20	0.41
299	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(5), GNAQ(1), GNB1(1), MYLK(5), PLCB1(3), ROCK1(1)	15472119	19	19	19	5	5	9	1	1	3	0	0.20	0.42
300	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(1), HK3(2), IMPA1(1), PGM1(1), PGM3(1), TGDS(2)	7469631	10	10	10	2	1	4	2	2	1	0	0.20	0.42
301	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(3), G6PD(1), GCLC(1), GCLM(1), GGT1(1), GPX5(1), GSS(1), GSTA1(1), GSTA4(1), GSTO2(1), GSTZ1(1), IDH1(1), PGD(2)	13306722	16	16	16	2	5	3	6	0	2	0	0.21	0.43
302	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	55	APC(3), AXIN1(1), CCND1(1), CCND3(5), CSNK1E(1), DVL3(1), FBXW2(1), FZD1(1), FZD3(2), FZD6(2), FZD9(1), JUN(1), LDLR(1), MAPK10(1), MYC(1), PAFAH1B1(1), PLAU(2), PPP2R5C(1), PPP2R5E(1), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKCZ(1), PRKD1(1), RHOA(2), SFRP4(1), TCF7(3), WNT10B(1), WNT11(2), WNT2B(1), WNT5B(1), WNT6(1), WNT7A(5)	40121952	52	46	52	21	11	17	10	6	5	3	0.21	0.43
303	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	18	CAMK2A(1), CAMK2D(3), ITPKB(7), ITPR1(7), ITPR3(4), NFAT5(1), PDE6A(1), PDE6B(2), PDE6C(2), PDE6G(1), SLC6A13(1), TF(1)	25751037	31	31	31	11	7	6	6	4	8	0	0.21	0.43
304	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1B(2), BMPR2(2)	4549818	5	5	4	3	1	1	0	0	3	0	0.21	0.43
305	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(1), IDI1(2), SQLE(1)	3217422	5	5	5	4	2	2	0	0	1	0	0.22	0.43
306	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(2), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(1), RELA(1), TNFRSF11A(2), TRAF6(1)	8257002	11	11	11	3	3	4	1	1	2	0	0.22	0.44
307	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2	FAH(1), GSTZ1(1)	983073	2	2	2	1	0	2	0	0	0	0	0.22	0.44
308	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(5), DYRK1B(1), GLI2(2), GLI3(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), SMO(2), SUFU(2)	11675703	18	16	18	8	4	5	4	4	1	0	0.22	0.44
309	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), CNDP1(2), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), HIBCH(2), MLYCD(2), UPB1(3)	19599099	27	25	27	8	2	9	9	3	4	0	0.22	0.44
310	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT2(1), TYR(3)	3468894	5	5	5	2	1	3	1	0	0	0	0.23	0.45
311	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), KHK(1), LCT(3), PGM1(1), PYGL(1), PYGM(2), TREH(1)	9918441	10	10	10	0	0	3	0	2	5	0	0.23	0.45
312	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(4), GNB1(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	6444477	9	9	9	3	3	2	2	1	1	0	0.23	0.45
313	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(1), HLA-DRB1(2)	1837368	3	3	3	2	0	1	1	1	0	0	0.23	0.45
314	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(3), ACADSB(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), CNDP1(2), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), MLYCD(2), UPB1(3)	21314787	29	27	29	10	2	12	7	4	4	0	0.23	0.45
315	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	31	ARG1(2), ARG2(1), ASL(3), ASS1(1), CKMT2(1), CPS1(2), DAO(1), EPRS(2), GATM(3), GLUD2(1), GOT2(1), NOS1(3), NOS3(2), P4HA3(1), PARS2(1), PYCRL(3), RARS(1), RARS2(1)	24333972	30	29	29	6	5	12	10	1	2	0	0.23	0.45
316	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(2), SULT1E1(2), SUOX(3)	4623840	7	7	7	2	1	4	1	0	1	0	0.23	0.45
317	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(1), NDUFA1(1), SDHA(1), SDHB(1), UQCRC1(2)	4941729	7	7	7	3	0	2	1	3	1	0	0.23	0.45
318	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(4), GAD1(2)	3937869	6	6	6	1	1	2	2	0	1	0	0.23	0.45
319	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(2)	1530126	3	3	3	1	1	1	1	0	0	0	0.23	0.45
320	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(1), PTPRU(5), STAT1(1), STAT2(1), TYK2(3)	9173151	12	12	11	5	2	3	3	2	2	0	0.24	0.46
321	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), GRB2(1), IL3RA(1), JAK2(2), MAP2K1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(3), STAT5B(4)	12693759	17	17	17	2	1	7	3	1	5	0	0.24	0.46
322	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(1)	1601106	3	3	3	0	2	0	1	0	0	0	0.24	0.46
323	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(3), ALDOB(2)	2934009	5	5	5	0	1	3	0	1	0	0	0.24	0.46
324	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA1(2), GABRA3(3), GABRA6(3), GPHN(1), UBQLN1(1)	8917116	12	12	12	4	2	7	1	1	1	0	0.24	0.46
325	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(3), SNCAIP(2)	4594434	7	7	7	2	2	2	2	1	0	0	0.25	0.47
326	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	9	GCK(2), HK1(1), HK3(2), IMPA1(1), PGM1(1), PGM3(1), TGDS(2)	7846839	10	10	10	2	1	4	2	2	1	0	0.25	0.47
327	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(1), AASDHPPT(2), AASS(3)	5207904	6	6	6	3	0	2	2	0	2	0	0.25	0.47
328	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	BAD(1), BRAF(2), CREB3(1), DUSP6(1), DUSP9(1), EEF2K(2), GRB2(1), MAP2K1(1), MAP3K8(2), MAPK1(1), MAPK3(1), MOS(2), NFKB1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(3), SOS2(1)	21150519	27	27	27	4	6	9	8	1	3	0	0.25	0.47
329	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(3), ALDOB(2), DLD(1), ENO1(1), ENO3(1), GCK(2), GOT2(1), GPI(2), HK1(1), HK3(2), LDHC(1), MDH2(2), PC(1), PCK1(1), PDHA1(1), PDHA2(1), PDHB(1), PDHX(1), PFKM(3), PFKP(2), PGK1(2)	29427801	32	31	32	7	6	15	4	4	3	0	0.26	0.48
330	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(1), IL22RA1(1), IL22RA2(1), JAK1(1), JAK2(2), JAK3(1), STAT1(1), STAT3(1), STAT5B(4), TYK2(3)	13375674	17	16	16	3	2	4	4	2	5	0	0.26	0.48
331	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	17	EXT1(3), EXT2(2), EXTL3(3), GLCE(2), HS2ST1(1), HS3ST2(1), HS3ST5(3), HS6ST2(3), HS6ST3(1), NDST3(1)	14650272	20	19	20	7	3	5	7	1	4	0	0.26	0.48
332	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(1), CYP11B2(3), CYP17A1(1), HSD3B2(2)	5218551	8	8	8	1	4	2	1	1	0	0	0.26	0.49
333	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	27	CD4(1), CSF1(2), HLA-DRB1(2), IFNB1(1), IL12A(1), IL12B(1), IL15(1), IL1A(1), IL2(1), IL6(2), TGFB3(1)	9781044	14	13	14	6	4	2	3	2	3	0	0.26	0.49
334	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(2), AASS(3)	3507933	5	5	5	3	0	2	2	0	1	0	0.26	0.49
335	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ITGA4(1), ITGAL(1), ITGB1(2), ITGB2(3), SELE(1), SELL(4)	9914385	12	12	12	2	2	1	4	3	2	0	0.27	0.49
336	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP5(3), ARHGAP6(1), ARHGEF1(5), ARHGEF11(1), ARPC1A(1), ARPC1B(1), ARPC2(2), BAIAP2(1), GSN(1), LIMK1(3), MYLK(5), OPHN1(2), PIP5K1A(1), ROCK1(1), TLN1(7), VCL(3)	34057725	38	34	38	17	7	10	7	3	11	0	0.27	0.49
337	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3), PNPO(2)	3425799	5	5	5	1	0	2	2	0	1	0	0.27	0.49
338	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	16	ACY1(2), ALDH18A1(1), ARG1(2), ARG2(1), ASL(3), CKMT2(1), CPS1(2), GATM(3)	11416119	15	15	15	3	2	7	4	1	1	0	0.27	0.50
339	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(1), CD8A(1), CSF1(2), IL2(1), IL6(2)	4508751	7	7	7	2	1	2	2	0	2	0	0.27	0.50
340	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	C1GALT1(1), C1GALT1C1(1), GALNT10(2), GALNT11(3), GALNT13(1), GALNT3(1), GALNT4(1), GALNT5(2), GALNT7(2), GALNTL1(1), GALNTL5(1), GCNT4(1), OGT(2), ST3GAL1(1), ST6GALNAC1(2), WBSCR17(4)	23704785	26	24	26	11	9	5	4	2	6	0	0.28	0.50
341	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ABAT(3), ACAT1(1), ACSM1(1), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), HADH(1), HMGCS1(1), HMGCS2(1), HSD17B10(1), HSD17B4(3), ILVBL(2), L2HGDH(1), OXCT1(1), OXCT2(1), PDHA1(1), PDHA2(1), PDHB(1), PLA1A(2), RDH11(2), RDH12(1), RDH14(1)	29395353	38	36	38	14	8	11	13	3	3	0	0.28	0.50
342	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A13(4), CYP2A6(1), CYP2A7(1), XDH(3)	6075381	9	9	9	1	3	2	3	1	0	0	0.29	0.51
343	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	ACY1(2), ADC(1), AGMAT(1), ALDH18A1(1), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(2), ARG1(2), ARG2(1), ASL(3), ASS1(1), CPS1(2), GATM(3), MAOA(2), SAT1(1), SAT2(1)	21234681	27	27	27	5	3	13	7	1	3	0	0.29	0.52
344	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS2(2), ABAT(3), ADSL(1), AGXT(1), AGXT2(1), ASL(3), ASPA(1), ASS1(1), CAD(7), CRAT(3), DARS(1), DARS2(1), DLD(1), GAD1(2), GAD2(3), GOT2(1), GPT2(2), NARS(1), NARS2(1), PC(1), PDHA1(1), PDHA2(1), PDHB(1)	26791908	40	35	40	6	7	17	9	4	3	0	0.29	0.52
345	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(3), CPS1(2), GLS(1)	5560776	8	8	8	0	1	3	2	1	1	0	0.29	0.52
346	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ITGAL(1), ITGAM(1), ITGB2(3), SELE(1), SELL(4)	8792901	10	10	10	1	2	1	3	1	3	0	0.30	0.53
347	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), MST1(3)	4472247	5	5	5	0	1	1	1	1	1	0	0.30	0.54
348	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CDC25B(3), CDK7(1), MNAT1(1), XPO1(2)	6424704	9	9	9	3	2	3	1	2	1	0	0.31	0.54
349	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(3), AGT(3), KNG1(1), NOS3(2)	6494670	9	9	9	2	3	2	2	0	2	0	0.31	0.54
350	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(3), BCAT2(2), IARS(5), IARS2(2), ILVBL(2), LARS2(2), PDHA1(1), PDHA2(1), PDHB(1)	13871013	19	18	19	6	5	8	4	0	2	0	0.31	0.54
351	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(2), GRB2(1), IL2(1), IL2RG(1), JAK1(1), JAK3(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(3), STAT5B(4)	17205552	22	21	22	6	1	9	5	2	5	0	0.31	0.54
352	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(1), CD3G(1), CD4(1), CREBBP(2), GNAS(4), GNB1(1), HLA-DRB1(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTPRC(1), ZAP70(1)	15967458	20	20	20	8	6	4	5	3	2	0	0.31	0.54
353	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(1), CD3G(1), CD4(1), CREBBP(2), GNAS(4), GNB1(1), HLA-DRB1(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTPRC(1), ZAP70(1)	15967458	20	20	20	8	6	4	5	3	2	0	0.31	0.54
354	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(12), APC(3), EPHB2(1), GNAI1(1), GNAQ(1), ITPR1(7), ITPR3(4), KCNJ3(1), MAPK1(1), PITX2(1), PTX3(1), RHO(2), RYR1(5)	34497294	40	38	30	13	7	19	6	1	7	0	0.31	0.54
355	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(1), MBTPS1(1), MBTPS2(1), SCAP(3), SREBF2(3)	7526922	10	10	10	6	2	3	2	2	1	0	0.31	0.54
356	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CD3E(1), CD3G(1), CD4(1)	1925586	3	3	3	1	0	2	1	0	0	0	0.31	0.54
357	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(7), MAP2(7), PRKAR2A(1), PRKAR2B(1)	13720941	16	16	16	6	2	5	0	7	2	0	0.32	0.55
358	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	46	ADCY4(1), ADCY8(2), CACNA1A(5), CACNA1B(1), GNAS(4), GNB1(1), GNB3(2), GRM4(1), ITPR3(4), PDE1A(2), PLCB2(2), PRKACA(1), TAS1R1(1), TAS1R2(1), TAS2R1(1), TAS2R10(1), TAS2R13(1), TAS2R14(1), TAS2R16(2), TAS2R3(1), TAS2R43(3), TAS2R46(1), TAS2R8(1), TAS2R9(2)	40245660	42	39	42	24	7	13	9	4	9	0	0.32	0.55
359	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(9), CDC25B(3)	10220106	12	11	12	3	0	5	0	3	4	0	0.32	0.55
360	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(1), APC(3), AXIN1(1), BMP10(1), BMP2(2), BMP4(2), BMP5(1), BMPR2(2), CHRD(2), FZD1(1), MEF2C(2), NPPA(1), RFC1(2), TGFB3(1), TGFBR1(2), TGFBR3(2)	25249107	26	25	25	16	2	13	4	3	4	0	0.32	0.55
361	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(1), CBS(1), CTH(1), GGT1(1), LCMT1(1), LCMT2(3), MAT2B(1), METTL2B(2), PAPSS1(2), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1), SEPHS1(1)	17718636	23	20	23	7	2	10	7	0	4	0	0.33	0.57
362	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(2), CS(1), HAO1(3), HAO2(1), MDH2(2), MTHFD1(4), MTHFD1L(1)	9514869	15	13	15	2	4	6	3	1	1	0	0.33	0.57
363	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACYP1(1), ECHS1(1), EHHADH(2), GCDH(1), SDHB(1)	5613504	7	7	7	5	0	2	3	2	0	0	0.34	0.57
364	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	CHST11(1), PAPSS1(2), SULT1A1(1), SULT1E1(2), SUOX(3)	6736002	9	9	9	5	2	4	2	0	1	0	0.34	0.58
365	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), HSD17B1(1), HSD17B2(1), HSD17B4(3), HSD3B2(2)	6020625	8	8	8	1	4	1	1	1	1	0	0.34	0.58
366	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(1), EPHB1(2), ITGA1(3), ITGB1(2), L1CAM(1), LYN(3), SELP(3)	12027054	15	15	15	4	4	6	4	1	0	0	0.34	0.58
367	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS2(2), DHRS7(1), PON1(1), PON3(1), RDH11(2), RDH12(1), RDH14(1)	6518499	9	8	9	3	2	1	2	1	3	0	0.35	0.59
368	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(3), ACAA1(1), ACAA2(1), ACAT1(1), ALDH1B1(1), ALDH9A1(1), AOX1(3), BCAT1(3), BCAT2(2), BCKDHA(1), DLD(1), ECHS1(1), EHHADH(2), HADH(1), HADHB(1), HIBCH(2), HMGCS1(1), HMGCS2(1), HSD17B10(1), HSD17B4(3), MCCC1(2), OXCT1(1), OXCT2(1), PCCA(1)	31026879	36	36	36	11	5	14	12	2	3	0	0.35	0.59
369	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACOT11(2), ACYP1(1), DHRS2(2), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(3), GCDH(1), ITGB1BP3(1), MYST3(1), MYST4(5), PNPLA3(4)	19064214	25	22	25	8	6	4	6	4	2	3	0.35	0.59
370	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ACP6(1), ACPP(1), ACPT(2), ENPP1(3), ENPP3(2), MTMR6(1), TYR(3)	11073894	14	14	14	4	3	4	4	2	1	0	0.35	0.59
371	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(2), IL6R(1), JAK1(1), JAK2(2), JAK3(1), PTPRU(5), STAT3(1)	11162112	13	13	13	6	1	4	0	2	6	0	0.36	0.60
372	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(1), GNAQ(1), GNAS(4), GNB1(1), LIMK1(3), MAP2K1(1), MAPK1(1), MAPK3(1), NOX1(1), PIK3C2G(1), PLCB1(3), PTK2(1), RAF1(1), ROCK2(2)	18579015	23	22	23	4	3	11	7	0	2	0	0.37	0.60
373	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), CD3G(1), CD8A(1), ITGAL(1), ITGB2(3), PTPRC(1)	7738848	10	10	10	1	2	3	3	0	2	0	0.37	0.61
374	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB11A(1), RAB1A(1), RAB6A(1)	3261024	3	3	3	0	0	0	1	0	2	0	0.37	0.61
375	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(3), G6PD(1), GCLC(1), GCLM(1), GGT1(1), GPX5(1), GSS(1), GSTA1(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTZ1(1), IDH1(1), TXNDC12(1)	14852058	16	16	16	2	4	4	6	0	2	0	0.38	0.62
376	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(1), CAMK1G(1), CAMK2A(1), CAMK2D(3), MEF2A(1), MEF2C(2), PPARA(1), PPP3CA(3), PPP3CB(2), SLC2A4(1)	14370408	16	16	16	7	2	3	7	0	4	0	0.38	0.62
377	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(1), CASP8(2), RIPK1(3), TNFRSF1A(1)	5788419	7	7	7	2	0	3	1	0	3	0	0.38	0.62
378	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	65	MRPL13(1), MRPS7(2), RPL13A(2), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL29(1), RPL35(2), RPL3L(1), RPL41(1), RPS10(1), RPS2(1), RPS21(1), RPS27(1), RPS5(2), RPS6(1)	15928419	21	20	21	6	5	5	6	4	1	0	0.38	0.62
379	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(1), NR0B2(2), NR1H4(1)	3914547	5	5	5	4	0	2	3	0	0	0	0.38	0.62
380	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(1), HLA-DRB1(2), IL2(1)	3054168	4	4	4	3	0	1	2	1	0	0	0.38	0.62
381	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	22	NRF1(1), UBE2A(1), UBE2D2(2), UBE2J1(3), UBE2J2(1), UBE3A(1)	7147179	9	9	9	1	0	3	3	0	3	0	0.38	0.62
382	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(3), ARHGDIB(1), CASP1(1), CASP8(2), JUN(1), PRF1(2)	9689784	11	11	11	2	0	5	2	0	4	0	0.39	0.64
383	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(2), CS(1), HAO1(3), HAO2(1), MDH2(2), MTHFD1(4), MTHFD1L(1)	9980295	15	13	15	2	4	6	3	1	1	0	0.40	0.64
384	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(1), PDHB(1), SDHB(1)	18572424	24	23	24	10	2	11	9	2	0	0	0.40	0.64
385	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT2(2), ST8SIA1(1)	4510272	4	4	3	1	2	0	0	0	2	0	0.40	0.64
386	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	42	ABCA1(5), ABCA10(2), ABCA12(4), ABCA13(13), ABCA3(2), ABCA4(5), ABCA5(3), ABCA6(1), ABCA8(4), ABCA9(3), ABCB1(3), ABCB10(1), ABCB11(4), ABCB6(1), ABCB7(1), ABCB8(2), ABCC1(3), ABCC10(2), ABCC11(1), ABCC12(3), ABCC2(3), ABCC4(3), ABCC5(1), ABCC6(2), ABCC8(7), ABCC9(3), ABCD1(2), ABCD2(1), ABCD3(2), ABCG5(1), CFTR(6), TAP1(1)	83159154	95	83	95	28	25	29	23	6	12	0	0.40	0.64
387	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	1124019	1	1	1	0	0	0	0	0	1	0	0.40	0.64
388	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(1), PTK2B(3), SHC1(1), SOS1(3)	6313671	8	8	8	1	2	2	3	0	1	0	0.41	0.65
389	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP68(1), SRP72(1), SRPR(7)	5603871	9	7	9	3	1	2	2	2	2	0	0.41	0.65
390	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(2), JAK3(1), MAPK1(1), MAPK3(1), STAT3(1), TYK2(3)	8584017	10	9	9	2	0	3	3	1	3	0	0.41	0.65
391	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(1), ACAT1(1), ECHS1(1), EHHADH(2), HADHB(1)	6045975	7	7	7	5	1	2	2	1	1	0	0.42	0.66
392	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(2), CBS(1), CTH(1)	3350763	4	4	4	0	0	2	0	0	2	0	0.42	0.66
393	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	89	CD2BP2(1), CLK4(1), COL2A1(3), CPSF1(2), CPSF3(1), CPSF4(2), CSTF2T(1), CSTF3(3), DDX20(2), DHX15(1), DHX16(1), DHX38(2), DHX8(1), DICER1(1), FUS(1), GIPC1(1), NCBP1(1), NUDT21(1), NXF1(2), PABPN1(1), PAPOLA(1), POLR2A(2), PRPF4(2), PRPF4B(3), PRPF8(5), PSKH1(2), PTBP1(2), RBM17(1), RBM5(1), SF3B1(10), SF3B2(1), SF3B4(1), SF4(4), SFRS16(3), SFRS2(1), SFRS4(2), SFRS5(1), SFRS9(1), SNRPB(1), SPOP(1), SRPK1(1), SRRM1(1), SUPT5H(4), TXNL4A(1), XRN2(3)	77043213	84	73	80	17	15	24	26	4	13	2	0.42	0.66
394	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(2), EP300(3), ESR1(2), MAPK1(1), MAPK3(1)	10444200	9	9	8	2	2	2	0	1	4	0	0.43	0.66
395	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDFT1(1), FDPS(1), IDI1(2), NQO1(1), PMVK(1), SQLE(1), VKORC1(1)	7224750	8	8	8	7	2	4	1	0	1	0	0.43	0.66
396	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(2), UXS1(2)	3016650	5	4	5	0	2	1	0	2	0	0	0.43	0.67
397	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), AMT(1), ATIC(3), MTHFD1(4), MTHFD1L(1), MTHFS(1), MTR(5)	13366041	16	15	16	7	3	4	2	2	5	0	0.43	0.67
398	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), JUN(1), MAPK14(1), THBS1(3)	5522244	6	5	6	3	0	3	0	1	2	0	0.44	0.67
399	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	23	ABAT(3), ALDH5A1(1), CAD(7), CPS1(2), EPRS(2), GAD1(2), GAD2(3), GCLC(1), GCLM(1), GLS(1), GMPS(1), GOT2(1), GPT2(2), GSS(1), PPAT(1), QARS(2)	23776272	31	28	31	3	4	11	11	2	3	0	0.44	0.67
400	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	20	ALDOA(3), ALDOB(2), GOT2(1), GPT2(2), MDH2(2), ME2(1), ME3(1), PGK1(2), TKT(1)	12363702	15	15	15	2	4	9	1	1	0	0	0.44	0.67
401	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCR2(4), CCR3(1), CCR7(2), CD4(1), IL12A(1), IL12B(1), IL12RB1(2), IL18R1(1), IL2(1), TGFB3(1)	14461668	15	15	15	7	1	6	2	1	5	0	0.44	0.67
402	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), CD3G(1), CD4(1), ITGAL(1), ITGB2(3), PTPRC(1)	8179431	10	10	10	2	2	3	3	0	2	0	0.44	0.67
403	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CAPN2(2), EP300(3), HDAC1(2), HDAC2(2), PPP3CA(3), PPP3CB(2)	17211129	19	17	18	7	4	5	4	0	6	0	0.45	0.68
404	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH7(2), ADHFE1(1), AKR1C1(1), AKR1C2(2), AKR1C3(1), AKR1C4(1), ALDH3B1(2), ALDH3B2(2), CYP1B1(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(1), CYP2C9(2), CYP2F1(1), CYP2S1(3), CYP3A4(3), CYP3A7(4), EPHX1(1), GSTA1(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTZ1(1), UGT1A10(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B15(2), UGT2B28(1), UGT2B4(1)	41307825	49	46	49	19	10	14	13	4	8	0	0.45	0.68
405	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(3), ACE2(1), AGT(3), ANPEP(3), CTSA(1), CTSG(1), ENPEP(1), MAS1(2)	14904786	15	15	15	6	4	4	2	1	4	0	0.45	0.68
406	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH11(2), RDH12(1), RDH14(1)	3500328	4	4	4	2	0	1	2	0	1	0	0.45	0.68
407	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(2), DHRS7(1), ESCO1(3), MYST3(1), MYST4(5), PNPLA3(4)	12283089	16	14	16	3	5	2	2	2	2	3	0.45	0.68
408	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(1), CBS(1), CTH(1), DNMT3A(3), DNMT3B(1), MAT2B(1), MTR(5)	12459018	14	13	14	4	1	5	3	3	2	0	0.46	0.69
409	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), AP2A1(3), AP2M1(2), BIN1(1), DNM1(2), EPS15(1), PPP3CA(3), PPP3CB(2), SYNJ2(1)	15971007	17	17	17	6	0	7	4	1	5	0	0.46	0.69
410	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), EPOR(1), GRIN1(1), JAK2(2), NFKB1(1), RELA(1)	9009390	8	8	8	3	0	2	0	2	4	0	0.47	0.70
411	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), AMT(1), ATIC(3), MTHFD1(4), MTHFD1L(1), MTHFS(1), MTR(5)	13668213	16	15	16	7	3	4	2	2	5	0	0.47	0.70
412	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), GLB1(1), HEXB(1), LCT(3), ST3GAL1(1), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(1)	12058488	12	12	12	0	2	5	3	0	2	0	0.47	0.70
413	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(1), CD3G(1), IL2(1), TGFB3(1), TGFBR1(2), TGFBR3(2), TOB1(1)	7884864	9	9	9	3	0	6	3	0	0	0	0.48	0.71
414	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	107	ATP12A(3), ATP4A(4), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(1), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), COX10(2), COX4I2(1), COX5A(1), COX6C(1), COX7B2(1), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA2(1), NDUFA3(1), NDUFB9(1), NDUFS2(1), NDUFS3(1), NDUFV1(1), NDUFV2(1), PPA1(1), SDHA(1), SDHB(1), TCIRG1(1), UQCRC1(2), UQCRC2(1)	39958698	44	42	44	8	6	10	11	9	8	0	0.48	0.71
415	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK1(1), JAK2(2), PTPRU(5), STAT1(1)	8494785	9	9	9	4	1	3	0	1	4	0	0.48	0.71
416	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), ACO2(2), IDH1(1), MDH2(2), SDHB(1), SUCLA2(1)	6645249	8	8	8	2	2	2	4	0	0	0	0.48	0.71
417	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(1), HDAC9(1), MEF2A(1), MEF2C(2)	5971446	6	6	6	2	1	1	1	0	3	0	0.48	0.71
418	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(1), BRAF(2), CREB3(1), MAPK1(1), RAF1(1), SNX13(1), TERF2IP(2)	8413665	9	9	9	1	1	2	5	0	1	0	0.49	0.72
419	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(1), BAK1(1), BID(4), CASP6(1), CASP8(2), DFFB(2)	9767355	11	11	11	0	2	4	1	0	4	0	0.49	0.72
420	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	37	ARNTL(1), AZIN1(1), CBX3(1), CRY1(1), EIF4G2(1), ETV6(1), HSPA8(3), IDI1(2), MYF6(1), NCKAP1(3), NR1D2(1), PER1(2), PER2(3), PPP2CB(2), TOB1(1), UCP3(1), VAPA(1), ZFR(4)	26284401	30	28	30	11	7	9	5	3	6	0	0.49	0.72
421	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(3), ESR1(2), GREB1(1), MTA3(1)	7239960	7	7	7	3	2	2	1	1	1	0	0.49	0.72
422	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	ARSB(3), GLB1(1), GUSB(1), HEXB(1), HGSNAT(1), HPSE(3), HPSE2(1), HYAL2(1), IDS(2), LCT(3), NAGLU(1)	14409954	18	17	18	3	3	7	6	0	2	0	0.50	0.73
423	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	FLT3(2), IGF1(1), IL1A(1), IL6(2), KITLG(2), TGFB3(1)	6119490	9	7	9	4	3	1	3	0	2	0	0.50	0.73
424	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(3), GLB1(1), GUSB(1), HEXB(1), IDS(2), LCT(3), NAGLU(1)	9843912	12	12	12	1	2	5	4	0	1	0	0.51	0.74
425	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(2), HDAC3(1), NCOA1(1), NCOA2(1), NCOA3(4), NCOR2(3), POLR2A(2), RARA(1), TBP(1)	17054973	16	16	16	7	2	4	5	1	4	0	0.51	0.74
426	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	106	ADA(2), ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADK(1), ADSL(1), AK2(1), AK5(1), AMPD1(3), ATIC(3), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(1), ENPP1(3), ENPP3(2), ENTPD1(2), FHIT(1), GMPS(1), GUCY1A2(2), GUCY2C(5), GUCY2D(1), GUCY2F(2), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(2), NT5E(3), PAICS(1), PAPSS1(2), PDE1A(2), PDE4A(1), PDE4B(2), PDE4C(3), PDE4D(3), PDE5A(1), PDE6B(2), PDE6C(2), PDE6G(1), PDE9A(3), PFAS(1), POLB(1), POLD2(1), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2A(2), POLR2B(3), POLR2H(1), PPAT(1), PRPS2(1), PRUNE(3), RRM2(1)	91146939	103	85	102	35	22	28	25	10	18	0	0.51	0.74
427	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(1), BHMT(1), CBS(1), CTH(1), DNMT3A(3), DNMT3B(1), MAT2B(1), MTAP(1), MTR(5)	14677650	16	15	16	4	1	7	3	3	2	0	0.52	0.74
428	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(2), JAK1(1), JAK2(2), TYK2(3)	7770282	9	8	8	2	1	0	4	2	2	0	0.52	0.74
429	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(2), JAK1(1), JAK2(2), TYK2(3)	7770282	9	8	8	2	1	0	4	2	2	0	0.52	0.74
430	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ALDH1B1(1), ALDH3B1(2), ALDH3B2(2), ALDH9A1(1), AMDHD1(1), AOC2(1), AOC3(2), ASPA(1), CARM1(1), CNDP1(2), DDC(1), HAL(2), LCMT1(1), LCMT2(3), MAOA(2), METTL2B(2), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1), PRPS2(1)	28319499	34	29	34	10	6	8	10	4	6	0	0.52	0.74
431	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C2(1), C3(2), C5(3), C6(4), C7(3), C9(1), MASP1(1), MASP2(1), MBL2(1)	15790008	17	17	17	4	2	6	4	2	3	0	0.52	0.75
432	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(3), ALDOB(2), GOT2(1), GPT2(2), MDH2(2), ME3(1), PGK1(2), TKT(1), TKTL1(1), TKTL2(1)	13850733	16	16	16	4	4	10	1	1	0	0	0.52	0.75
433	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C2(1), C3(2), C5(3), C6(4), C7(3), C9(1)	13106457	14	14	14	4	2	5	3	2	2	0	0.53	0.75
434	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), JUN(1), MAPK3(1), OPRK1(2), POLR2A(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	9177714	10	10	10	3	3	2	2	2	1	0	0.53	0.75
435	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	FDFT1(1), FDPS(1), HMGCS1(1), IDI1(2), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1)	8798478	9	9	9	8	2	3	2	0	2	0	0.53	0.75
436	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACA(1), ACACB(8), MCAT(1)	8967816	10	10	10	1	5	5	0	0	0	0	0.53	0.75
437	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	49	AKR1C3(1), ALOX12(1), CBR3(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(1), CYP2C9(2), CYP4F2(1), DHRS4(1), GGT1(1), GPX5(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PTGDS(1), PTGS2(1), TBXAS1(1)	27431742	31	30	29	5	6	10	8	3	4	0	0.53	0.75
438	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), DRD2(1), GRM1(2), PLCB1(3), PPP3CA(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	11477466	13	13	13	6	7	2	3	1	0	0	0.53	0.75
439	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	EGF(2), EGFR(4), GRB2(1), MAP2K1(1), MAPK1(1), MAPK3(1), PTPRB(2), RAF1(1), RASA1(2), SHC1(1), SOS1(3)	18580536	19	19	19	7	2	6	4	4	3	0	0.54	0.75
440	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	1294371	1	1	1	1	1	0	0	0	0	0	0.54	0.75
441	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(2), CTBS(1), CYB5R1(2), GFPT2(3), GNE(3), GNPNAT1(1), HEXB(1), HK1(1), HK3(2), MTMR6(1), NAGK(1), NANS(1), PGM3(1), RENBP(1)	20888907	22	21	22	2	4	5	8	2	3	0	0.54	0.75
442	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(1), AOC3(2), CES1(1), ESD(1)	4679610	5	5	5	2	0	3	1	0	1	0	0.54	0.75
443	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(5), CETP(1), LCAT(1), LDLR(1), LPL(1), LRP1(7), SCARB1(2), SOAT1(1)	18633264	19	19	19	8	10	3	3	0	3	0	0.54	0.75
444	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1B1(1), ALDH9A1(1), CYP2C19(1), CYP2C9(2), DHRS2(2), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(3), MYST3(1), MYST4(5), PNPLA3(4)	22605609	26	24	26	9	6	5	7	3	2	3	0.55	0.76
445	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	12	NDUFA1(1), NDUFA10(1), NDUFS2(1), NDUFV1(1), NDUFV2(1)	4791657	5	5	5	1	0	2	2	0	1	0	0.55	0.76
446	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGAP3(1), ARFGEF2(2), COPA(1), GBF1(4), GPLD1(2), KDELR3(1)	11684322	13	13	13	0	3	2	3	3	2	0	0.55	0.76
447	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	138	ADA(2), ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), ADK(1), ADSL(1), AK2(1), AK5(1), AK7(1), AMPD1(3), ATIC(3), ENPP1(3), ENPP3(2), ENTPD1(2), ENTPD4(1), ENTPD6(1), FHIT(1), GMPR2(1), GMPS(1), GUCY1A2(2), GUCY2C(5), GUCY2D(1), GUCY2F(2), IMPDH1(2), IMPDH2(1), NME6(1), NME7(2), NPR1(1), NPR2(2), NT5C1B(3), NT5C3(1), NT5E(3), PAICS(1), PAPSS1(2), PDE10A(1), PDE11A(1), PDE1A(2), PDE2A(3), PDE3B(1), PDE4A(1), PDE4B(2), PDE4C(3), PDE4D(3), PDE5A(1), PDE6G(1), PDE9A(3), PFAS(1), POLA1(4), POLD2(1), POLD4(1), POLE2(1), POLE3(1), POLR1A(1), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(2), POLR2B(3), POLR2H(1), POLR3A(1), POLR3B(2), POLR3GL(2), PPAT(1), PRPS2(1), PRUNE(3), RRM2(1), XDH(3)	118570569	128	102	127	46	27	35	38	9	19	0	0.55	0.76
448	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(2), DFFB(2), HMGB2(1), PRF1(2), SET(1)	7647588	9	8	9	3	2	2	0	2	3	0	0.55	0.76
449	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	9	JUN(1), KEAP1(2), MAPK1(1), MAPK14(1), MAPK8(2)	6141291	7	6	7	1	0	3	0	0	2	2	0.56	0.77
450	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), CASP8(2), DFFB(2), PRF1(2), SCAP(3), SREBF2(3)	12415416	13	13	13	2	2	5	1	2	3	0	0.56	0.77
451	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(2), CAPN1(3), CDK5(1), MAPT(1)	6567678	7	7	7	1	0	4	1	1	1	0	0.56	0.77
452	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH7(2), ADHFE1(1)	4275531	4	4	4	1	0	3	1	0	0	0	0.57	0.77
453	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	62	ACYP1(1), ADH1A(1), ADH7(2), ADHFE1(1), ALDH1B1(1), ALDH3B1(2), ALDH3B2(2), ALDH9A1(1), ALDOA(3), ALDOB(2), DLD(1), ENO1(1), ENO3(1), G6PC2(1), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(3), PFKP(2), PGK1(2), PGM1(1), PGM3(1)	40754688	40	37	40	11	6	19	5	7	3	0	0.57	0.77
454	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25B(3), GRB2(1), PTPRA(1)	6812559	7	7	7	2	0	4	0	2	1	0	0.57	0.77
455	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), IFNB1(1), JAK1(1), STAT1(1), STAT2(1), TYK2(3)	8103381	8	8	7	3	2	0	3	2	1	0	0.57	0.78
456	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(1), NFKB1(1), NOX1(1), RELA(1), SOD1(1), XDH(3)	7579143	8	8	8	0	2	1	4	0	1	0	0.58	0.78
457	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(2), JAK3(1), PTPRU(5), SOAT1(1)	10227711	10	10	10	5	2	3	0	1	4	0	0.58	0.78
458	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), EHHADH(2)	3434418	3	3	3	4	0	0	2	1	0	0	0.58	0.78
459	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), AOX1(3), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(1), CYP2C9(2), CYP2D6(2), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(2), CYP4F8(2), DDC(1), ECHS1(1), EHHADH(2), GCDH(1), KYNU(1), MAOA(2), WARS2(1)	41060916	49	43	49	19	5	18	13	5	8	0	0.59	0.78
460	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), HLA-DRB1(2), IL12A(1), IL12B(1), IL12RB1(2), IL18R1(1), IL2(1)	9572667	9	9	9	6	1	0	3	3	2	0	0.59	0.78
461	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(1), CPT1A(2), LEPR(3), PRKAA2(2), PRKAB1(1), PRKAG2(1)	10819887	10	10	10	5	4	3	1	0	2	0	0.59	0.78
462	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGF(2), EGFR(4), TF(1), TFRC(1)	9514362	9	9	9	4	1	2	2	4	0	0	0.59	0.78
463	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SNAP23(2), SNAP25(1), STX10(1), STX17(1), STX3(1), STX6(1), STX7(1), TSNARE1(3), USE1(1)	12155832	12	12	12	9	3	2	1	3	3	0	0.59	0.79
464	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	IL10RA(1), IL10RB(3), IL1A(1), IL6(2), JAK1(1), STAT1(1), STAT3(1)	9056034	10	9	10	1	3	2	1	1	3	0	0.60	0.80
465	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(1), ANXA4(1), ANXA6(1), CYP11A1(1), EDN1(2), EDNRB(1), PLA2G4A(6), PTGDR(1), PTGDS(1), PTGFR(1), PTGS2(1), S100A6(1), TBXAS1(1)	15335229	19	18	18	3	6	5	6	2	0	0	0.61	0.80
466	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), ARSB(3), ARSE(1), CYP11B1(2), CYP11B2(3), HSD17B2(1), HSD3B2(2), SRD5A1(1), SRD5A2(2), SULT1E1(2), UGT1A10(1), UGT1A6(2), UGT2B15(2), UGT2B4(1)	19720779	24	21	24	6	6	7	6	3	2	0	0.61	0.81
467	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(2), UXS1(2)	3811119	5	4	5	0	2	1	0	2	0	0	0.61	0.81
468	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), HMGCS1(1), HMGCS2(1), OXCT1(1), OXCT2(1)	5172414	5	5	5	2	0	2	2	1	0	0	0.62	0.81
469	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), CA2(1), CA4(1), CA6(2), CA9(3), CPS1(2), CTH(1), GLS(1), HAL(2)	14028690	14	14	14	3	2	5	3	1	3	0	0.62	0.81
470	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), PCYT1A(1), PDHA1(1), PDHA2(1)	5048199	5	5	5	1	0	4	1	0	0	0	0.62	0.81
471	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(1), FARSB(3), GOT2(1), PAH(1)	6516471	7	7	7	0	1	3	2	1	0	0	0.62	0.81
472	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(1), ACADSB(1), ACADVL(2), ACAT1(1), ACOX1(2), ACOX3(1), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(2), ADH1A(1), ADH7(2), ADHFE1(1), ALDH1B1(1), ALDH9A1(1), CPT1A(2), CPT1C(2), CPT2(1), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HADHB(1), HSD17B10(1), HSD17B4(3), PECI(1)	35644128	36	35	36	13	6	15	6	5	4	0	0.62	0.81
473	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CREBBP(2), EP300(3), HDAC3(1), IKBKB(2), NFKB1(1), RELA(1), RIPK1(3), TNFRSF1A(1), TRAF6(1)	16086096	15	15	14	3	1	8	0	1	5	0	0.63	0.82
474	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA3(1), P2RY1(1), P2RY2(1)	4245111	4	4	4	2	1	3	0	0	0	0	0.63	0.82
475	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GCK(2), GNE(3), HEXB(1), HK1(1), HK3(2), PGM3(1), RENBP(1)	12357618	11	11	11	2	2	4	3	0	2	0	0.63	0.82
476	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), ARSE(1), CARM1(1), CYP11B1(2), CYP11B2(3), HSD17B1(1), HSD17B2(1), HSD3B2(2), LCMT1(1), LCMT2(3), METTL2B(2), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1), SRD5A1(1), SRD5A2(2), SULT1E1(2), UGT1A10(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B15(2), UGT2B28(1), UGT2B4(1)	35708010	41	36	41	14	9	10	14	3	5	0	0.64	0.82
477	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(1), ARHGDIB(1), CASP1(1), CASP2(2), CASP6(1), CASP8(2), DFFB(2), LMNB1(1), PRF1(2)	13661115	13	13	13	2	1	5	2	2	3	0	0.64	0.82
478	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	40	AGMAT(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(2), ARG1(2), ARG2(1), ASL(3), CKMT2(1), CPS1(2), DAO(1), GATM(3), GOT2(1), MAOA(2), NOS1(3), NOS3(2), P4HA3(1), RARS(1)	30495543	33	30	33	10	5	17	7	1	3	0	0.64	0.82
479	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(2)	2765178	2	2	2	0	0	0	1	0	1	0	0.64	0.82
480	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(1), CD3G(1), CD4(1), HLA-DRB1(2), PTPRC(1), ZAP70(1)	6755775	7	7	7	5	2	2	2	1	0	0	0.64	0.83
481	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(1), GPR109B(1), GPR161(2), GPR34(1), GPR75(1)	7405749	7	7	7	7	0	2	2	3	0	0	0.65	0.83
482	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(1), CTH(1), GGT1(1), MAT2B(1), PAPSS1(2), SEPHS1(1)	8761974	8	8	8	4	0	6	1	0	1	0	0.65	0.83
483	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	EPHB2(1), FBXW7(1), GRB2(1), ITK(3), ITPKB(7), LAT(1), LCP2(1), MAPK1(1), NFAT5(1), NFKB1(1), NFKB2(4), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PLCG1(4), PTPRC(1), RAF1(1), RASGRP2(2), RASGRP4(1), SOS1(3), SOS2(1), VAV1(1), ZAP70(1)	39911547	42	37	42	12	10	13	4	6	6	3	0.65	0.83
484	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH3B1(2), ALDH3B2(2), ALDH9A1(1), AOC2(1), AOC3(2), ASPA(1), CNDP1(2), DDC(1), HAL(2), MAOA(2), PRPS2(1)	18196230	21	19	21	7	4	7	3	4	3	0	0.65	0.83
485	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(4), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(4), COL4A6(3), F12(1), F2(2), F2R(2), F5(7), F8(1), FGA(3), KLKB1(1), PROC(1), SERPINC1(2)	33025473	35	34	35	11	6	11	8	6	4	0	0.65	0.83
486	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAD(1), BAK1(1), BCL2L11(1), BID(4), CES1(1)	8450676	9	9	9	0	3	4	0	0	2	0	0.65	0.83
487	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(1), GRIA2(1)	2589249	2	2	2	1	1	1	0	0	0	0	0.66	0.83
488	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC1A(1), ARPC1B(1), ARPC2(2), NCKAP1(3), NTRK1(1), PIR(1), WASF1(1), WASF3(1), WASL(1)	11461749	12	12	12	5	6	1	4	0	1	0	0.66	0.83
489	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	52	ADH1A(1), ADH7(2), ADHFE1(1), AGK(2), AGPAT3(2), AGPAT6(1), AKR1B1(2), ALDH1B1(1), ALDH9A1(1), CEL(1), DAK(2), DGKA(3), DGKD(1), DGKE(1), DGKG(4), DGKH(1), DGKI(5), GK2(1), GLA(2), GLB1(1), LCT(3), LPL(1), PNLIP(1), PNLIPRP1(2), PNPLA3(4), PPAP2A(1)	41479191	47	41	46	13	9	16	8	4	7	3	0.66	0.83
490	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	53	CAD(7), CTPS2(2), DPYD(1), DPYS(1), ENTPD1(2), NT5E(3), POLB(1), POLD2(1), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2A(2), POLR2B(3), POLR2H(1), RRM2(1), TK2(1), UCK2(2), UMPS(1), UPB1(3), UPP1(2)	40676103	42	38	42	12	7	10	10	4	11	0	0.66	0.83
491	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(1), PLCB1(3), RELA(1)	6134700	6	6	6	1	2	3	0	0	1	0	0.66	0.83
492	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ACAA2(1), ADH1A(1), ADH7(2), ADHFE1(1), AKR1C4(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(1), SRD5A1(1), SRD5A2(2)	17098068	19	17	19	5	1	12	3	1	2	0	0.67	0.83
493	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH1A(1), ADH7(2), ADHFE1(1), DHRS2(2), DHRS7(1), ESCO1(3), MYST3(1), MYST4(5), PNPLA3(4)	18603351	20	18	20	4	5	5	3	2	2	3	0.67	0.83
494	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(3), CDK7(1), NEK1(1)	5474079	5	5	5	2	1	2	0	2	0	0	0.67	0.83
495	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C2(1), C3(2), C5(3), C6(4), C7(3), C9(1), MASP1(1)	15607488	15	15	15	4	2	5	3	2	3	0	0.67	0.83
496	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT3(1), CHPF(1), CHST11(1), CHST3(1), DSE(4), UST(1), XYLT2(1)	9839856	10	10	10	7	3	4	2	0	1	0	0.67	0.83
497	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IL12A(1), IL12B(1), IL15(1), IL1A(1), IL2(1), IL6(2)	7624773	8	7	8	4	3	0	1	1	3	0	0.68	0.84
498	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAA2(1), ADH1A(1), ADH7(2), ADHFE1(1), AKR1C4(1), ALDH1B1(1), ALDH9A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(1), RDH11(2), RDH12(1), RDH14(1), SLC27A5(2), SOAT1(1), SRD5A1(1), SRD5A2(2)	23033517	23	22	23	6	2	11	5	1	4	0	0.68	0.84
499	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), CA2(1), CA4(1), CA6(2), CA9(3), CPS1(2), CTH(1), GLS(1), GLUD2(1), HAL(2)	15598362	15	15	15	4	2	5	4	1	3	0	0.68	0.84
500	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREBBP(2), EP300(3), NCOA3(4), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RARA(1)	14774487	14	12	13	5	4	1	0	3	6	0	0.69	0.85
501	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), NFKB1(1), PLCB1(3), RAF1(1), RELA(1)	11420682	11	11	11	3	2	6	1	0	2	0	0.69	0.85
502	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CRY1(1), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(2), PER2(3), PER3(2)	11869884	12	12	12	7	4	4	1	0	3	0	0.69	0.85
503	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), HLCS(1)	2248545	2	2	2	0	1	0	1	0	0	0	0.70	0.86
504	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), ASCC3(1), ATP13A2(1), DDX41(1), DDX50(3), DDX55(3), DDX56(1), DHX58(2), ENTPD7(1), ERCC3(2), GCH1(1), IFIH1(1), NUDT8(1), RAD54B(4), RAD54L(2), SETX(6), SKIV2L2(1), SMARCA2(3), SMARCA5(1)	45087510	43	38	42	6	9	9	12	6	7	0	0.70	0.86
505	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR24(1), EBP(1), FDFT1(1), FDPS(1), IDI1(2), NQO1(1), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1), VKORC1(1)	13375167	12	12	12	10	3	5	2	0	2	0	0.71	0.86
506	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	56	B3GALNT1(1), B3GALT1(1), B3GALT4(2), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(1), B4GALT6(1), FUT2(2), FUT3(2), PIGA(1), PIGB(1), PIGG(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(1), ST6GALNAC4(1), ST8SIA1(1)	32978829	28	28	27	5	9	7	4	4	4	0	0.71	0.86
507	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(2), GLS(1)	3483090	3	3	3	1	0	1	0	1	1	0	0.72	0.88
508	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(1)	1909869	1	1	1	0	0	1	0	0	0	0	0.72	0.88
509	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	35	EEF1D(1), EEF2(1), EEF2K(2), EIF1AX(2), EIF2AK1(1), EIF2AK3(1), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF4A2(3), EIF4G3(2), EIF5(1), EIF5B(2), ETF1(1), GSPT2(2), PABPC1(3), PABPC3(1), SLC35A4(2)	30443322	28	27	28	12	4	5	7	5	7	0	0.73	0.88
510	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC1A(1), ARPC1B(1), ARPC2(2), WASF1(1), WASL(1)	6118476	6	6	6	5	3	0	2	0	1	0	0.73	0.88
511	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN2(4), ACTN3(1), CTNNA1(1), CTNNA2(2), PTK2(1), PXN(1), VCL(3)	14072292	13	13	13	10	4	4	2	0	3	0	0.73	0.88
512	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	42	ADH1A(1), ADH7(2), ADHFE1(1), AGPAT3(2), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), CEL(1), DGKA(3), DGKD(1), DGKE(1), DGKG(4), DGKH(1), GLA(2), GLB1(1), LCT(3), LPL(1), PNLIP(1), PNLIPRP1(2), PPAP2A(1)	33672405	35	33	34	12	4	17	6	3	5	0	0.74	0.89
513	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(1), AOC3(2), CES1(1), CES7(1), ESCO1(3), MYST3(1), MYST4(5), PLA1A(2), PNPLA3(4)	19069284	21	19	21	8	6	6	2	1	3	3	0.74	0.89
514	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2)	8614437	8	8	8	7	0	5	2	1	0	0	0.74	0.89
515	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(3), ABCB11(4), ABCC1(3)	11039418	10	10	10	9	1	3	4	1	1	0	0.74	0.89
516	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	33	ARSE(1), B4GALT6(1), CERK(1), DEGS1(2), ENPP7(1), GLA(2), GLB1(1), LCT(3), NEU2(1), PPAP2A(1), SGMS1(1), SGPP1(1), SGPP2(1), SMPD2(2), SPHK2(2), SPTLC1(1), SPTLC2(2), UGT8(1)	23712897	25	24	25	7	4	8	8	1	4	0	0.74	0.89
517	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS2(2), CARS2(1), DARS(1), DARS2(1), EARS2(3), EPRS(2), FARS2(1), FARSA(1), FARSB(3), GARS(1), IARS(5), IARS2(2), LARS2(2), NARS(1), NARS2(1), PARS2(1), QARS(2), RARS(1), RARS2(1), SARS(2), SARS2(2), TARS(4), TARS2(2), WARS2(1)	40526031	43	39	43	9	7	14	14	3	5	0	0.75	0.89
518	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	ARSB(3), GLB1(1), GUSB(1), HEXB(1), HGSNAT(1), HPSE(3), HPSE2(1), HYAL2(1), IDS(2), LCT(3), MAN2B1(2), MAN2B2(3), MANBA(1), NAGLU(1), NEU2(1)	24132186	25	24	25	7	3	7	11	1	3	0	0.75	0.89
519	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CRY1(1), CSNK1E(1), PER1(2)	5832021	5	5	5	4	1	3	0	0	1	0	0.76	0.90
520	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	55	ATP12A(3), ATP6V0A4(2), ATP6V0B(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), ATP7B(1), COX10(2), COX5A(1), COX6C(1), NDUFA1(1), NDUFA10(1), NDUFS2(1), NDUFV1(1), NDUFV2(1), SDHA(1), SDHB(1), UQCRC1(2)	25584234	24	23	24	8	5	6	5	2	6	0	0.76	0.90
521	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(3), MMP9(1)	5542524	4	4	3	4	1	3	0	0	0	0	0.76	0.90
522	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(1), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(2), POLR2B(3), POLR2H(1), POLR3A(1), POLR3B(2), POLR3GL(2)	17322162	17	16	17	8	3	3	6	1	4	0	0.77	0.91
523	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(4), COL4A6(3), SLC23A1(2), SLC2A3(2)	18875103	19	18	19	9	3	6	7	1	2	0	0.77	0.91
524	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO3(1), FARS2(1), GOT2(1), PAH(1)	6207201	5	5	5	0	0	2	1	2	0	0	0.77	0.91
525	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(2), POLR2A(2), POLR2B(3), POLR2H(1)	8445606	8	7	8	5	3	0	2	0	3	0	0.78	0.91
526	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(1), ACO2(2), IDH1(1), MDH2(2), SUCLA2(1)	9951396	9	9	9	2	2	4	3	0	0	0	0.78	0.91
527	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), OXCT1(1)	2475174	2	2	2	1	0	1	1	0	0	0	0.78	0.92
528	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(1), ATF3(1), CYR61(1), IFRD1(1), IL1A(1), IL1R1(1)	7695246	6	6	6	2	1	1	3	1	0	0	0.80	0.93
529	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1)	5692089	5	5	5	3	0	5	0	0	0	0	0.80	0.93
530	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1)	5692089	5	5	5	3	0	5	0	0	0	0	0.80	0.93
531	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	83	CAD(7), CTPS2(2), DPYD(1), DPYS(1), ENTPD1(2), ENTPD4(1), ENTPD6(1), NME6(1), NME7(2), NT5C1B(3), NT5C3(1), NT5E(3), POLA1(4), POLD2(1), POLD4(1), POLE2(1), POLE3(1), POLR1A(1), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(2), POLR2B(3), POLR2H(1), POLR3A(1), POLR3B(2), POLR3GL(2), RRM2(1), TK2(1), UCK2(2), UMPS(1), UPB1(3), UPP1(2), UPRT(1)	59012265	61	53	61	19	11	14	19	5	12	0	0.80	0.93
532	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	27	ATG7(2), IFNA10(1), IFNA14(1), IFNA2(2), IFNA4(1), PIK3C3(2), PIK3R4(3), PRKAA2(2)	14310582	14	13	14	5	4	3	3	2	2	0	0.80	0.93
533	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(2), EPHB2(1), F2(2), F2RL2(1), JUN(1), MAP2K5(1), MAPK1(1), MAPK8(2), MYEF2(1), PLD1(1), PLD3(1), PTK2(1), RAF1(1), RASAL1(1), TEC(1), VAV1(1)	19738524	19	18	19	5	1	9	3	3	3	0	0.81	0.93
534	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK1(1), JAK2(2), STAT1(1)	6231537	4	4	4	1	0	0	0	1	3	0	0.81	0.93
535	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(2), CS(1), DLD(1), IDH3A(1), IDH3G(1), MDH2(2), OGDH(1), PC(1), PDHA1(1), PDHA2(1), PDHB(1), PDHX(1), PDK1(1), PDK2(1), PDK4(1), PDP2(1), SDHA(1), SDHB(1), SUCLA2(1)	20894484	21	20	21	6	4	8	7	2	0	0	0.81	0.93
536	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), ACO2(2), CS(1), DLD(1), IDH1(1), IDH3A(1), IDH3G(1), MDH2(2), PC(1), PCK1(1), SDHA(1), SDHB(1), SUCLA2(1)	15259179	15	14	15	3	2	6	6	1	0	0	0.81	0.93
537	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(1), ALG10B(3), ALG11(1), ALG13(2), ALG2(1), ALG6(1), ALG9(1), B4GALT1(2), B4GALT3(1), DPAGT1(2), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT3(1), MGAT5(2), MGAT5B(4), RPN1(1)	30462588	29	28	29	13	5	8	6	3	7	0	0.81	0.93
538	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(1), AASDHPPT(2), AASS(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), DOT1L(3), ECHS1(1), EHHADH(2), GCDH(1), PLOD1(1), PLOD2(1), PLOD3(1)	25485369	22	21	22	14	1	9	5	3	4	0	0.82	0.93
539	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(1)	3752814	2	2	2	3	0	0	0	0	2	0	0.82	0.94
540	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLUD2(1)	3079011	2	2	2	1	0	0	1	0	1	0	0.82	0.94
541	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A4(2), ATP6V0B(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), FDXR(3)	11895234	10	10	9	3	2	2	3	1	2	0	0.82	0.94
542	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CTH(1), GOT2(1), LDHC(1)	4869228	3	3	3	0	0	2	0	0	1	0	0.82	0.94
543	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(1), HS3ST2(1), XYLT2(1)	4417998	3	3	3	2	1	1	1	0	0	0	0.83	0.94
544	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(1), HS3ST2(1), XYLT2(1)	4417998	3	3	3	2	1	1	1	0	0	0	0.83	0.94
545	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(1), UCHL3(1), UGT1A10(1), UGT1A6(2), UGT2B15(2), UGT2B4(1)	12038715	10	10	10	5	2	2	3	1	2	0	0.83	0.94
546	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(3), COL4A1(4), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(4), COL4A6(3)	19148376	19	17	19	8	3	7	6	0	3	0	0.83	0.94
547	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), CS(1), PC(1), PDHA1(1)	6708624	5	5	5	2	0	3	1	1	0	0	0.83	0.94
548	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	DARS(1), EPRS(2), FARS2(1), GARS(1), IARS(5), LARS2(2), NARS(1), QARS(2), RARS(1), SARS(2), TARS(4), WARS2(1)	23973495	23	22	23	6	3	7	7	2	4	0	0.84	0.94
549	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	EGF(2), EGFR(4), GRB2(1), MET(4), PDGFRA(3)	14554956	14	12	14	4	3	3	1	4	0	3	0.84	0.94
550	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1), APOBEC2(1), APOBEC3B(1), APOBEC4(1)	5493345	4	4	4	1	0	2	1	0	1	0	0.84	0.94
551	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	GLB1(1), HEXB(1), LCT(3), MAN2B1(2), MAN2B2(3), MANBA(1), NEU2(1)	14468259	12	12	12	4	0	2	7	1	2	0	0.84	0.94
552	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(1), ACO2(2), CLYBL(2), CS(1), DLD(1), IDH1(1), IDH3A(1), IDH3G(1), MDH2(2), OGDH(1), OGDHL(1), PC(1), PCK1(1), PCK2(1), SDHA(1), SDHB(1), SUCLA2(1)	22200516	22	20	22	5	2	11	7	2	0	0	0.84	0.94
553	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), NDUFA13(1)	2989272	2	2	2	0	0	2	0	0	0	0	0.85	0.95
554	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACAT1(1), ECHS1(1)	3846609	2	2	2	3	0	1	0	1	0	0	0.86	0.95
555	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(1), ACADSB(1), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), AOX1(3), BCAT1(3), BCKDHA(1), ECHS1(1), EHHADH(2), HADHB(1), MCCC1(2), OXCT1(1), PCCA(1)	25785513	24	23	24	10	3	10	7	2	2	0	0.86	0.96
556	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF5(1)	8609367	5	5	5	3	2	1	1	0	1	0	0.86	0.96
557	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(4), NRG3(1)	6545370	5	5	5	2	2	2	1	0	0	0	0.87	0.96
558	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC7(1), CDK2(1), MCM10(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), NACA(3), ORC2L(1), ORC3L(1), POLD2(1), POLD4(1), POLE2(1), RFC1(2), RFC4(3), RPA1(1), UBC(6)	36393981	31	30	31	8	7	7	9	1	5	2	0.88	0.97
559	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACAT1(1), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), AOX1(3), CARM1(1), CYP1B1(1), DDC(1), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HSD17B10(1), HSD17B4(3), INMT(1), KYNU(1), LCMT1(1), LCMT2(3), LNX1(1), MAOA(2), METTL2B(2), OGDH(1), OGDHL(1), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1), WARS2(1)	44382780	43	38	43	20	5	15	14	2	7	0	0.88	0.97
560	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA5(1), PSMB6(1), PSMD1(4), PSMD2(1), PSMD6(2)	11864814	9	9	9	3	2	2	3	0	2	0	0.88	0.97
561	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	20	ARSB(3), ARSE(1), GLA(2), GLB1(1), LCT(3), NEU2(1), PPAP2A(1), SMPD2(2), SPTLC1(1), SPTLC2(2)	16675230	17	14	17	2	3	6	5	1	2	0	0.88	0.97
562	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(1), RANGAP1(2)	6114420	4	4	4	0	1	0	1	1	1	0	0.88	0.97
563	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), CAMK2A(1), CAMK2D(3), CNGA3(3), CNGA4(2), GUCA1A(1), GUCA1C(1), PRKACA(1), PRKG1(1), PRKG2(4)	22180743	19	19	19	10	4	4	5	4	2	0	0.89	0.97
564	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(2), EP300(3), LPL(1), NCOA1(1), NCOA2(1), PPARG(1)	13479609	9	9	8	4	2	1	1	1	4	0	0.89	0.97
565	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), PPARG(1)	4189848	2	2	2	1	1	0	1	0	0	0	0.89	0.97
566	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1)	2775318	1	1	1	0	1	0	0	0	0	0	0.89	0.97
567	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(1), ERCC3(2), GTF2E2(1), GTF2F2(1), ILK(2), MNAT1(1), POLR1A(1), POLR1B(2), POLR2A(2), POLR2B(3), POLR2H(1), POLR3B(2), POLR3E(2), TAF6(1), TAF7(1), TBP(1)	26232180	24	22	24	11	4	7	7	0	6	0	0.89	0.97
568	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1)	3155061	1	1	1	1	0	1	0	0	0	0	0.90	0.97
569	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(2), AASS(3), ACAT1(1), ALDH1B1(1), ALDH9A1(1), DOT1L(3), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HSD17B10(1), HSD17B4(3), OGDH(1), OGDHL(1), PIPOX(1), PLOD1(1), PLOD2(1), PLOD3(1), RDH11(2), RDH12(1), RDH14(1), SETD7(1), SETDB1(7)	41347878	38	37	37	18	6	14	9	4	5	0	0.90	0.97
570	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	15	ALOX12(1), GGT1(1), PLA2G6(2), PTGDS(1), PTGS2(1), TBXAS1(1)	9843912	7	7	7	1	0	4	2	0	1	0	0.90	0.97
571	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADVL(2), ACSL3(1), ACSL4(1), CPT1A(2), CPT2(1), EHHADH(2), SLC25A20(1)	12381447	10	10	10	7	1	6	3	0	0	0	0.91	0.98
572	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(2), CS(1), OGDH(1), SDHA(1), SUCLA2(1)	7055919	6	5	6	2	1	2	2	1	0	0	0.91	0.98
573	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT1(2), B4GALT3(1), DPAGT1(2), MAN1B1(1), MGAT3(1), MGAT5(2), RPN1(1)	13911066	10	10	10	3	0	4	2	1	3	0	0.92	0.99
574	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLB(1), POLD2(1), POLD4(1), POLE2(1), POLE3(1), POLG(1), POLH(2), POLI(3), POLL(1), POLQ(4), REV1(1), REV3L(4)	31128279	25	24	25	7	3	8	5	3	6	0	0.92	0.99
575	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(1), BAD(1), CASP1(1), CASP2(2), CASP6(1), CASP8(2), CD40(1), CD40LG(1), DFFB(2), FAS(1), FASLG(1), IKBKE(1), NFKB1(1), NGFR(1), NTRK1(1), PTPN13(4), RIPK1(3), SFRS2IP(1), TNFRSF1A(1), TRAF6(1)	32007924	28	26	28	5	9	9	2	2	6	0	0.92	0.99
576	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	13	ADSL(1), IMPDH1(2), POLB(1), POLG(1), PRPS2(1)	8741187	6	6	6	3	2	2	0	1	1	0	0.93	0.99
577	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	MAPK14(1), MAPK8(2), NFKB1(1), RELA(1), TNFSF13B(1), TRAF6(1)	10531404	7	7	7	1	1	4	0	0	2	0	0.93	0.99
578	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(3), PRKAR2A(1), PRKAR2B(1)	7388004	5	5	5	3	2	2	0	1	0	0	0.93	0.99
579	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS2(1), CDO1(1), CTH(1), GOT2(1), LDHC(1)	8927256	5	5	5	1	0	2	1	0	2	0	0.93	0.99
580	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH7(2), ADHFE1(1), ALDH1B1(1), ALDH9A1(1)	9670011	6	6	6	2	0	5	1	0	0	0	0.93	0.99
581	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CREBBP(2), EP300(3), IKBKB(2), MAP2K3(1), MAPK14(1), NFKB1(1), RELA(1), TGFBR1(2), TLR2(1)	21208317	14	14	13	4	1	6	1	1	5	0	0.94	0.99
582	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(3), ACACA(1), ACACB(8), ACAT1(1), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HIBCH(2), LDHC(1), MLYCD(2), PCCA(1), SUCLA2(1)	29235141	25	24	25	7	4	12	7	1	1	0	0.94	0.99
583	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	FURIN(1)	3715803	1	1	1	2	0	0	0	1	0	0	0.94	0.99
584	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(3), BCHE(1), CES1(1), CYP3A4(3), UGT1A10(1), UGT1A6(2)	17340921	14	14	14	6	4	3	6	0	1	0	0.94	0.99
585	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	31	GTF2E2(1), GTF2F2(1), TAF1(6), TAF1L(6), TAF4B(2), TAF5L(1), TAF6(1), TAF7(1), TBPL2(2)	26955162	21	21	20	5	4	5	8	0	4	0	0.95	1.00
586	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(2), ATP6V0B(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1)	11287848	7	7	7	3	2	0	2	1	2	0	0.95	1.00
587	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(2), ATP6V0B(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1)	11287848	7	7	7	3	2	0	2	1	2	0	0.95	1.00
588	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(2), ATP6V0B(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1)	11287848	7	7	7	3	2	0	2	1	2	0	0.95	1.00
589	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(3), AXIN1(1), CREBBP(2), EP300(3), FZD1(1), HDAC1(2), PITX2(1), TRRAP(3)	23100948	16	15	15	8	2	3	4	2	5	0	0.96	1.00
590	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	PTGS2(1)	3974880	1	1	1	0	0	1	0	0	0	0	0.96	1.00
591	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	GLB1(1), HEXB(1), LCT(3), MANBA(1), NEU2(1)	11744148	7	7	7	1	0	2	3	0	2	0	0.96	1.00
592	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFB(2), HMGB2(1), TOP2A(1)	7465575	4	4	4	0	2	1	0	1	0	0	0.96	1.00
593	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(1)	4176159	1	1	1	1	0	1	0	0	0	0	0.96	1.00
594	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA5(1), PSMB6(1), PSMB8(1)	6472869	3	3	3	0	1	0	2	0	0	0	0.96	1.00
595	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD2(1), POLG(1), POLL(1), POLQ(4)	12519351	8	8	8	1	0	5	0	1	2	0	0.97	1.00
596	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	APAF1(1), FAS(1), FASLG(1), IL1A(1), MAPKAPK3(1)	8080059	5	5	5	1	4	1	0	0	0	0	0.97	1.00
597	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(3), ACACA(1), ACADSB(1), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), LDHC(1), MLYCD(2), PCCA(1), SUCLA2(1)	24317241	19	18	19	9	1	10	5	2	1	0	0.97	1.00
598	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA5(1), PSMB6(1), RPN1(1), UBE2A(1), UBE3A(1)	9834279	5	5	5	1	0	1	3	0	1	0	0.97	1.00
599	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(3), GRM1(2), GRM2(1), GRM3(3), GRM4(1), GRM5(1), GRM8(1)	15237885	12	11	12	6	6	2	2	1	1	0	0.97	1.00
600	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR6(1), TPK1(1)	4689750	2	2	2	0	1	1	0	0	0	0	0.98	1.00
601	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	20	APC(3), AXIN1(1), CCND1(1), CREBBP(2), CSNK2A1(1), FZD1(1), HDAC1(2), MYC(1), NLK(1), WIF1(1)	19757283	14	13	14	7	2	5	2	3	2	0	0.98	1.00
602	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(1), ACACB(8), ACAT1(1), ACYP1(1), AKR1B1(2), ALDH1B1(1), ALDH9A1(1), DLD(1), LDHC(1), MDH2(2), ME2(1), ME3(1), PC(1), PCK1(1), PCK2(1), PDHA1(1), PDHA2(1), PDHB(1)	33688629	27	26	27	4	6	16	4	0	1	0	0.98	1.00
603	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(1), UGT1A10(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B15(2), UGT2B28(1), UGT2B4(1)	18672810	13	13	13	8	4	2	5	0	2	0	0.98	1.00
604	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	11	CNR1(1), PTGDR(1), PTGFR(1)	7365189	3	3	3	5	0	0	3	0	0	0	0.98	1.00
605	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(1), BID(4), CASP6(1), CASP8(2), DFFB(2), NFKB1(1), RELA(1), RIPK1(3), SPTAN1(2)	23946117	17	16	17	2	1	8	2	0	6	0	0.98	1.00
606	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(1), PPOX(1)	5778279	2	2	2	2	1	0	1	0	0	0	0.98	1.00
607	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(1), ALDH9A1(1)	5833035	2	2	2	1	0	2	0	0	0	0	0.98	1.00
608	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS2(1), COX10(2), CP(2), EARS2(3), EPRS(2), GUSB(1), PPOX(1), UGT1A10(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B15(2), UGT2B28(1), UGT2B4(1)	29682822	22	21	22	11	7	2	8	1	4	0	0.99	1.00
609	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(1), ACAT1(1), ACYP1(1), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), DLD(1), LDHC(1), MDH2(2), ME2(1), ME3(1), PC(1), PCK1(1), PDHA1(1), PDHA2(1), PDHB(1)	26318370	21	19	21	6	3	14	3	0	1	0	0.99	1.00
610	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	APC(3), AXIN1(1), FZD1(1)	11563656	5	5	5	7	0	2	2	1	0	0	0.99	1.00
611	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(1), ANAPC5(4), ANAPC7(1), CDC23(1), CDC27(1), CUL1(1), FBXW7(1), SMURF2(1), UBA1(3), UBE2D2(2), WWP2(4)	29671161	20	20	20	7	4	9	3	1	3	0	0.99	1.00
612	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	CP(2), EPRS(2), GUSB(1), PPOX(1), UGT1A10(1), UGT1A6(2), UGT2B15(2), UGT2B4(1)	19384638	12	11	12	6	3	2	4	1	2	0	1.00	1.00
613	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	10	ALAS2(1)	5981079	1	1	1	2	1	0	0	0	0	0	1.00	1.00
614	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	22	GPLD1(2), PGAP1(2), PIGA(1), PIGB(1), PIGG(1)	17040270	7	7	7	3	1	3	2	1	0	0	1.00	1.00
615	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		1220856	0	0	0	0	0	0	0	0	0	0	1.00	1.00
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		384306	0	0	0	0	0	0	0	0	0	0	1.00	1.00
