rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	181	ACTB(2), ACTG1(1), ACTN2(4), ACTN3(1), ACTN4(4), AKT2(1), AKT3(2), ARHGAP5(3), BAD(1), BRAF(2), CAPN2(2), CAV1(1), CCND1(1), CCND3(5), COL11A1(2), COL11A2(1), COL1A1(6), COL1A2(3), COL2A1(3), COL3A1(1), COL4A1(4), COL4A2(2), COL4A4(1), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A3(5), COL6A6(4), COMP(3), CRKL(1), EGF(2), EGFR(4), ELK1(2), ERBB2(4), FARP2(3), FIGF(1), FLNA(4), FLNB(7), FLNC(8), FLT1(2), FN1(3), GRB2(1), GRLF1(4), HGF(3), IGF1(1), IGF1R(1), ILK(2), ITGA1(3), ITGA10(1), ITGA11(4), ITGA2(2), ITGA2B(2), ITGA4(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGAV(3), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB8(1), JUN(1), KDR(2), LAMA1(6), LAMA2(7), LAMA3(6), LAMA4(4), LAMB1(3), LAMB2(3), LAMB3(4), LAMB4(6), LAMC1(2), LAMC2(1), LAMC3(1), MAP2K1(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MET(4), MYL7(1), MYLK(5), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PARVA(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PIK3CB(3), PIK3CG(2), PIK3R3(1), PIP5K1C(3), PPP1R12A(1), PRKCG(1), PTK2(1), PXN(1), RAF1(1), RAPGEF1(3), RELN(10), RHOA(2), ROCK1(1), ROCK2(2), SHC1(1), SHC3(1), SHC4(2), SOS1(3), SOS2(1), SPP1(1), THBS1(3), THBS3(1), THBS4(1), TLN1(7), TLN2(4), TNC(3), TNN(3), TNR(1), TNXB(3), VAV1(1), VAV3(1), VCL(3), VWF(6)	259172823	320	212	319	111	57	101	70	27	59	6	<1.00e-15	<6.16e-13
2	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	126	ACTB(2), ACTG1(1), COL11A1(2), COL11A2(1), COL17A1(3), COL1A1(6), COL1A2(3), COL2A1(3), COL3A1(1), COL4A1(4), COL4A2(2), COL4A4(1), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A3(5), COL6A6(4), COMP(3), DSC2(3), DSC3(1), DSG1(2), DSG4(2), FN1(3), GJA1(2), GJA10(1), GJA4(1), GJA9(1), GJB2(1), GJB3(2), GJB4(1), GJB5(1), GJC1(1), INA(1), ITGA6(3), ITGB4(4), KRT1(3), KRT14(1), KRT15(1), KRT17(4), KRT18(1), KRT19(2), KRT2(2), KRT25(2), KRT28(1), KRT3(1), KRT33A(1), KRT34(1), KRT35(1), KRT36(2), KRT37(1), KRT4(2), KRT6A(1), KRT6C(1), KRT71(1), KRT72(1), KRT81(1), KRT82(2), KRT83(1), KRT84(1), KRT85(1), KRT86(1), KRT9(2), LAMA1(6), LAMA2(7), LAMA3(6), LAMA4(4), LAMB1(3), LAMB2(3), LAMB3(4), LAMB4(6), LAMC1(2), LAMC2(1), LAMC3(1), LMNB1(1), NES(3), RELN(10), SPP1(1), THBS1(3), THBS3(1), THBS4(1), TNC(3), TNN(3), TNR(1), TNXB(3), VWF(6)	166605270	202	161	201	72	41	74	42	10	35	0	5.43e-08	0.000017
3	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	84	ACVR1(1), ACVR1B(4), ACVR1C(1), ACVR2A(3), AMHR2(2), BMP2(2), BMP4(2), BMP5(1), BMP6(1), BMP8B(1), BMPR1B(2), BMPR2(2), CHRD(2), COMP(3), CREBBP(2), CUL1(1), E2F4(2), EP300(3), FST(1), GDF6(2), ID2(1), INHBA(1), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(2), MAPK1(1), MAPK3(1), MYC(1), NODAL(1), PITX2(1), PPP2CB(2), RBL1(1), RBL2(1), RHOA(2), ROCK1(1), ROCK2(2), RPS6KB2(3), SMAD2(3), SMAD3(2), SMAD4(1), SMAD9(2), SMURF2(1), SP1(1), TGFB3(1), TGFBR1(2), THBS1(3), THBS3(1), THBS4(1), ZFYVE16(3), ZFYVE9(3)	70610904	86	77	84	29	13	23	18	7	25	0	2.99e-06	0.00061
4	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	226	ACVR1B(4), ACVR1C(1), AKT2(1), AKT3(2), ARRB1(1), ATF4(1), BDNF(1), BRAF(2), CACNA1A(5), CACNA1B(1), CACNA1C(4), CACNA1D(4), CACNA1E(8), CACNA1F(6), CACNA1G(5), CACNA1I(2), CACNA1S(1), CACNA2D1(4), CACNA2D2(2), CACNA2D3(5), CACNA2D4(1), CACNB1(1), CACNB2(2), CACNG2(1), CACNG3(2), CACNG4(1), CACNG6(1), CD14(1), CDC25B(3), CRKL(1), DUSP10(1), DUSP16(3), DUSP6(1), DUSP7(1), DUSP9(1), EGF(2), EGFR(4), ELK1(2), FAS(1), FASLG(1), FGF11(1), FGF13(2), FGF18(2), FGF23(1), FGF3(1), FGF5(1), FGF6(1), FGF7(2), FGFR2(2), FGFR4(3), FLNA(4), FLNB(7), FLNC(8), GRB2(1), IKBKB(2), IL1A(1), IL1R1(1), IL1R2(3), JUN(1), KRAS(1), MAP2K1(1), MAP2K3(1), MAP2K5(1), MAP3K10(4), MAP3K12(2), MAP3K13(3), MAP3K4(3), MAP3K5(1), MAP3K6(1), MAP3K8(2), MAP4K1(1), MAP4K4(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPKAPK3(1), MAPT(1), MAX(1), MEF2C(2), MOS(2), MYC(1), NFATC4(3), NFKB1(1), NFKB2(4), NLK(1), NR4A1(1), NTRK1(1), NTRK2(1), PAK1(2), PAK2(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PPP3CA(3), PPP3CB(2), PRKACA(1), PRKCG(1), PTPN5(2), PTPN7(1), PTPRR(1), RAF1(1), RAPGEF2(1), RASA1(2), RASA2(1), RASGRF1(3), RASGRP2(2), RASGRP4(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KA6(3), SOS1(3), SOS2(1), SRF(1), STK3(1), STK4(1), TAOK1(2), TAOK2(1), TGFB3(1), TGFBR1(2), TNFRSF1A(1), TRAF6(1), ZAK(1)	193925472	253	175	250	69	54	88	46	18	44	3	9.28e-06	0.0014
5	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	77	ABL1(2), ABL2(2), AKT2(1), AKT3(2), ARAF(1), BAD(1), BRAF(2), BTC(1), CAMK2A(1), CAMK2D(3), CBLB(7), CBLC(3), CRKL(1), EGF(2), EGFR(4), ELK1(2), ERBB2(4), ERBB3(8), ERBB4(4), GAB1(1), GRB2(1), JUN(1), KRAS(1), MAP2K1(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MYC(1), NRG3(1), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PIK3CB(3), PIK3CG(2), PIK3R3(1), PLCG1(4), PLCG2(2), PRKCG(1), PTK2(1), RAF1(1), RPS6KB2(3), SHC1(1), SHC3(1), SHC4(2), SOS1(3), SOS2(1), STAT5B(4), TGFA(1)	68217357	99	86	99	24	13	28	24	17	17	0	0.000018	0.0022
6	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	120	ACACA(1), ACACB(8), AKT2(1), AKT3(2), ARAF(1), BAD(1), BRAF(2), CBLB(7), CBLC(3), CRKL(1), ELK1(2), G6PC2(1), GCK(2), GRB2(1), GYS1(5), GYS2(1), IKBKB(2), INPP5D(2), INSR(2), IRS1(1), IRS4(1), KRAS(1), LIPE(2), MAP2K1(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), PCK1(1), PCK2(1), PDE3A(6), PDE3B(1), PFKM(3), PFKP(2), PHKA2(4), PHKB(2), PHKG2(1), PIK3CB(3), PIK3CG(2), PIK3R3(1), PPARGC1A(1), PPP1R3A(6), PPP1R3B(1), PRKAA2(2), PRKAB1(1), PRKACA(1), PRKAG2(1), PRKAG3(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCI(1), PRKCZ(1), PTPRF(3), PYGB(3), PYGL(1), PYGM(2), RAF1(1), RAPGEF1(3), RPS6(1), RPS6KB2(3), SHC1(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS4(1), SORBS1(4), SOS1(3), SOS2(1), TRIP10(3), TSC1(2), TSC2(2)	104354289	141	118	141	39	31	51	22	12	25	0	0.000051	0.0053
7	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	145	AKT2(1), AKT3(2), CBLB(7), CBLC(3), CCND1(1), CCND3(5), CNTFR(1), CREBBP(2), CSF2RA(1), CSF2RB(2), CSF3R(2), EP300(3), EPOR(1), GH2(1), GHR(2), GRB2(1), IFNA10(1), IFNA14(1), IFNA2(2), IFNA4(1), IFNAR2(1), IFNB1(1), IFNK(1), IL10RA(1), IL10RB(3), IL11RA(1), IL12A(1), IL12B(1), IL12RB1(2), IL13RA1(1), IL13RA2(2), IL15(1), IL2(1), IL21(1), IL21R(1), IL22(1), IL22RA1(1), IL22RA2(1), IL23R(3), IL28B(3), IL28RA(1), IL2RG(1), IL3RA(1), IL5RA(1), IL6(2), IL6R(1), IL6ST(3), IRF9(2), JAK1(1), JAK2(2), JAK3(1), LEPR(3), LIF(3), LIFR(4), MYC(1), OSMR(3), PIAS2(1), PIAS4(2), PIK3CB(3), PIK3CG(2), PIK3R3(1), PRLR(1), SOCS4(1), SOCS5(1), SOS1(3), SOS2(1), SPRED1(2), SPRED2(1), STAM(1), STAM2(1), STAT1(1), STAT2(1), STAT3(1), STAT4(5), STAT5B(4), TPO(6), TSLP(1), TYK2(3)	102459630	141	113	139	35	32	34	26	16	30	3	0.000063	0.0055
8	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	BRAF(2), CPEB1(2), EGFR(4), ERBB2(4), ERBB4(4), ETS1(2), ETS2(3), ETV6(1), FMN2(7), GRB2(1), KRAS(1), MAP2K1(1), MAPK1(1), MAPK3(1), NOTCH2(4), NOTCH3(3), NOTCH4(6), PIWIL2(4), PIWIL4(1), RAF1(1), SOS1(3), SOS2(1), SPIRE1(1)	33021417	58	50	57	12	8	19	13	7	11	0	0.000083	0.0064
9	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	82	CD36(1), COL11A1(2), COL11A2(1), COL1A1(6), COL1A2(3), COL2A1(3), COL3A1(1), COL4A1(4), COL4A2(2), COL4A4(1), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A3(5), COL6A6(4), FN1(3), FNDC1(4), FNDC3A(1), GP1BA(3), GP6(1), HSPG2(5), ITGA1(3), ITGA10(1), ITGA11(4), ITGA2(2), ITGA2B(2), ITGA4(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGAV(3), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB8(1), LAMA1(6), LAMA2(7), LAMA3(6), LAMA4(4), LAMB1(3), LAMB2(3), LAMB3(4), LAMB4(6), LAMC1(2), LAMC2(1), LAMC3(1), RELN(10), SDC4(1), SPP1(1), SV2A(1), SV2B(1), THBS1(3), THBS3(1), THBS4(1), TNC(3), TNN(3), TNR(1), TNXB(3), VWF(6)	157698294	178	142	177	70	34	61	44	8	31	0	0.00014	0.0096
10	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	161	ADCY1(3), ADCY3(2), ADCY4(1), ADCY7(1), ADCY8(2), ADCY9(5), ADRA1A(1), ADRA1B(1), ATP2A1(2), ATP2B1(4), ATP2B2(4), ATP2B3(4), ATP2B4(1), AVPR1B(1), BDKRB1(2), CACNA1A(5), CACNA1B(1), CACNA1C(4), CACNA1D(4), CACNA1E(8), CACNA1F(6), CACNA1G(5), CACNA1I(2), CACNA1S(1), CAMK2A(1), CAMK2D(3), CD38(2), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CYSLTR1(1), CYSLTR2(1), EDNRB(1), EGFR(4), ERBB2(4), ERBB3(8), ERBB4(4), F2R(2), GNAQ(1), GNAS(4), GRIN1(1), GRIN2C(4), GRIN2D(3), GRM1(2), GRM5(1), GRPR(1), HRH2(2), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(3), ITPR1(7), ITPR3(4), LHCGR(4), LTB4R2(1), MYLK(5), NOS1(3), NOS3(2), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), PDE1A(2), PDE1B(1), PDGFRA(3), PDGFRB(2), PHKA2(4), PHKB(2), PHKG2(1), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(2), PLCE1(5), PLCG1(4), PLCG2(2), PLCZ1(1), PPP3CA(3), PPP3CB(2), PRKACA(1), PRKCG(1), PTGER3(2), PTGFR(1), PTK2B(3), RYR1(5), RYR2(13), RYR3(11), SPHK2(2), TACR2(1), TNNC2(1), TRPC1(2), VDAC2(1)	191542572	256	175	255	108	73	79	54	19	27	4	0.00023	0.014
11	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), LPO(5), MPO(1), PRDX1(1), TPO(6), TYR(3)	6880497	17	17	17	2	2	7	4	0	4	0	0.00029	0.016
12	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(3), CD14(1), CD19(1), CD1B(2), CD1C(2), CD1D(2), CD1E(1), CD2(2), CD22(1), CD33(1), CD34(1), CD36(1), CD37(1), CD38(2), CD3E(1), CD3G(1), CD4(1), CD5(2), CD55(2), CD8A(1), CD9(1), CR1(6), CR2(2), CSF1(2), CSF2RA(1), CSF3R(2), DNTT(2), EPOR(1), FCGR1A(1), FLT3(2), FLT3LG(1), GP1BA(3), HLA-DRB1(2), HLA-DRB5(1), IL11RA(1), IL1A(1), IL1R1(1), IL1R2(3), IL3RA(1), IL5RA(1), IL6(2), IL6R(1), ITGA1(3), ITGA2(2), ITGA2B(2), ITGA4(1), ITGA6(3), ITGAM(1), ITGB3(2), KIT(3), KITLG(2), TFRC(1), TPO(6)	61738911	93	78	93	26	17	28	25	7	16	0	0.00042	0.021
13	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(1), FADS2(4), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2)	7195851	20	19	18	1	3	5	6	5	1	0	0.00057	0.027
14	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	241	ACVR1(1), ACVR1B(4), ACVR2A(3), AMHR2(2), BMP2(2), BMPR1B(2), BMPR2(2), CCL11(1), CCL13(1), CCL21(1), CCL23(1), CCL7(1), CCR3(1), CCR7(2), CD40(1), CD40LG(1), CNTFR(1), CSF1(2), CSF2RA(1), CSF2RB(2), CSF3R(2), CX3CR1(2), EDA2R(1), EGF(2), EGFR(4), EPOR(1), FAS(1), FASLG(1), FLT1(2), FLT3(2), FLT3LG(1), FLT4(1), GH2(1), GHR(2), HGF(3), IFNA10(1), IFNA14(1), IFNA2(2), IFNA4(1), IFNAR2(1), IFNB1(1), IFNK(1), IL10RA(1), IL10RB(3), IL11RA(1), IL12A(1), IL12B(1), IL12RB1(2), IL13RA1(1), IL15(1), IL17B(2), IL17RA(2), IL17RB(3), IL18R1(1), IL18RAP(2), IL1A(1), IL1R1(1), IL1R2(3), IL1RAP(2), IL2(1), IL21(1), IL21R(1), IL22(1), IL22RA1(1), IL22RA2(1), IL23R(3), IL25(1), IL28B(3), IL28RA(1), IL2RG(1), IL3RA(1), IL5RA(1), IL6(2), IL6R(1), IL6ST(3), INHBA(1), INHBC(1), INHBE(1), KDR(2), KIT(3), KITLG(2), LEPR(3), LIF(3), LIFR(4), MET(4), NGFR(1), OSMR(3), PDGFB(1), PDGFRA(3), PDGFRB(2), PLEKHO2(1), PRLR(1), TGFB3(1), TGFBR1(2), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(2), TNFRSF1A(1), TNFRSF21(2), TNFRSF8(1), TNFSF13B(1), TNFSF18(1), TNFSF4(1), TPO(6), TSLP(1), XCR1(1)	127258014	176	136	174	54	45	46	35	17	30	3	0.00093	0.041
15	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(2), ALDH1A2(1), BCMO1(3), RDH5(2)	2893449	8	8	8	3	1	4	0	0	3	0	0.0019	0.072
16	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	190	ACTN2(4), ACTN3(1), ACTN4(4), APC(3), ARAF(1), ARHGEF1(5), ARHGEF12(2), ARHGEF4(2), ARHGEF6(1), ARHGEF7(2), ARPC1A(1), ARPC1B(1), ARPC2(2), BAIAP2(1), BDKRB1(2), BRAF(2), C3orf10(1), CD14(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CRKL(1), CYFIP2(2), DIAPH3(1), EGF(2), EGFR(4), EZR(2), F2(2), F2R(2), FGD3(2), FGF11(1), FGF13(2), FGF18(2), FGF23(1), FGF3(1), FGF5(1), FGF6(1), FGF7(2), FGFR2(2), FGFR4(3), FN1(3), GIT1(1), GRLF1(4), GSN(1), IQGAP1(1), IQGAP2(2), IQGAP3(3), ITGA1(3), ITGA10(1), ITGA11(4), ITGA2(2), ITGA2B(2), ITGA4(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGAD(1), ITGAL(1), ITGAM(1), ITGAV(3), ITGAX(2), ITGB1(2), ITGB2(3), ITGB3(2), ITGB4(4), ITGB5(2), ITGB8(1), KRAS(1), LIMK1(3), LIMK2(1), MAP2K1(1), MAPK1(1), MAPK3(1), MOS(2), MSN(1), MYH10(4), MYH14(5), MYH9(5), MYL7(1), MYLK(5), NCKAP1(3), NCKAP1L(3), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PIK3CB(3), PIK3CG(2), PIK3R3(1), PIP4K2A(1), PIP5K1A(1), PIP5K1C(3), PPP1R12A(1), PTK2(1), PXN(1), RAF1(1), RDX(1), RHOA(2), ROCK1(1), ROCK2(2), SCIN(2), SOS1(3), SOS2(1), SSH1(1), SSH2(1), SSH3(2), TIAM1(1), TIAM2(4), VAV1(1), VAV3(1), VCL(3), WAS(1), WASF1(1), WASL(1)	193775907	229	172	228	86	47	69	49	22	42	0	0.0019	0.072
17	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(9), ATR(2), BRCA1(8), BRCA2(10), CHEK2(2), FANCA(2), FANCD2(3), FANCF(1), FANCG(1), RAD17(2), RAD50(1), RAD9A(2)	32696430	43	39	43	4	3	10	6	4	20	0	0.0039	0.14
18	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	89	ANK2(4), B3GALT4(2), DGKI(5), IL6ST(3), RPL13A(2), RPL17(1), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL29(1), RPL35(2), RPL36(1), RPL3L(1), RPL4(1), RPL41(1), RPL5(2), RPLP2(1), RPS10(1), RPS14(1), RPS2(1), RPS21(1), RPS27(1), RPS4X(1), RPS5(2), RPS6(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3), RPS6KB2(3), TBC1D10C(2)	36936978	53	50	53	11	15	9	15	9	5	0	0.0044	0.14
19	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), LPO(5), MPO(1), TPO(6)	6052566	13	13	13	0	2	5	3	0	3	0	0.0048	0.14
20	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(1), ELK1(2), GRB2(1), JUN(1), KLK2(2), MAP2K1(1), MAPK3(1), MAPK8(2), NGFR(1), PLCG1(4), RAF1(1), SHC1(1), SOS1(3)	11184927	21	20	21	1	2	8	5	0	6	0	0.0049	0.14
21	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	76	ACVR1(1), ACVR1B(4), BMPR2(2), CDKL1(2), CDKL2(1), CDS1(2), CLK1(1), CLK4(1), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKA(3), DGKD(1), DGKE(1), DGKG(4), DGKH(1), IMPA1(1), INPP4A(2), INPP4B(3), INPPL1(1), MAP3K10(4), MOS(2), NEK1(1), NEK3(2), OCRL(3), PIK3C2A(2), PIK3C2B(2), PIK3C2G(1), PIK3CB(3), PIK3CG(2), PIM2(1), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCG1(4), PLCG2(2), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), PRKD1(1), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), TGFBR1(2)	78399438	96	89	94	29	19	27	23	9	18	0	0.0049	0.14
22	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	219	ADCYAP1R1(3), ADORA1(1), ADORA3(1), ADRA1A(1), ADRA1B(1), ADRA2B(1), AVPR1B(1), BDKRB1(2), BRS3(1), CALCR(1), CALCRL(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CNR1(1), CRHR1(3), CRHR2(1), CTSG(1), CYSLTR1(1), CYSLTR2(1), DRD2(1), DRD3(1), EDNRB(1), F2(2), F2R(2), F2RL2(1), FPR1(1), FSHR(3), GABBR2(1), GABRA1(2), GABRA3(3), GABRA6(3), GABRB2(1), GABRB3(1), GABRG1(2), GABRG2(2), GABRG3(1), GABRQ(3), GABRR1(1), GALR1(2), GALR2(1), GH2(1), GHR(2), GHRHR(1), GHSR(1), GIPR(1), GLRA2(1), GLRA3(1), GPR156(1), GPR50(2), GPR63(1), GPR83(3), GRIA1(6), GRIA2(1), GRIA3(2), GRIA4(1), GRID1(5), GRID2(2), GRIK1(5), GRIK2(5), GRIK3(3), GRIK4(1), GRIK5(2), GRIN1(1), GRIN2B(4), GRIN2C(4), GRIN2D(3), GRIN3A(4), GRM1(2), GRM2(1), GRM3(3), GRM4(1), GRM5(1), GRM6(1), GRM8(1), GRPR(1), HCRTR1(1), HCRTR2(1), HRH2(2), HRH4(1), HTR1A(1), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(3), LEPR(3), LHB(1), LHCGR(4), LTB4R2(1), MAS1(2), MC2R(1), MC3R(2), MC4R(1), MCHR2(1), NMUR1(1), NMUR2(1), NPFFR2(1), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(1), OPRK1(2), OPRM1(5), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), P2RY1(1), P2RY10(1), P2RY11(1), P2RY13(2), P2RY2(1), P2RY4(2), PARD3(3), PRLR(1), PTGDR(1), PTGER3(2), PTGFR(1), PTH2R(1), RXFP1(3), SSTR2(1), SSTR3(1), TAAR1(1), TAAR2(1), TAAR5(3), TAAR6(1), TACR2(1), THRB(1), TSHR(3)	153090678	226	159	225	83	49	79	55	20	20	3	0.0050	0.14
23	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	57	APAF1(1), ATM(9), ATR(2), BAI1(6), CASP8(2), CCNB1(2), CCNB3(3), CCND1(1), CCND3(5), CCNG2(2), CDK2(1), CDK6(1), CHEK2(2), DDB2(1), FAS(1), GTSE1(4), IGF1(1), IGFBP3(1), MDM2(1), PERP(2), RRM2(1), SERPINE1(1), SESN2(2), SIAH1(2), STEAP3(1), THBS1(3), TP53I3(1), TSC2(2)	42476967	61	52	61	7	5	21	7	7	16	5	0.0054	0.14
24	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	32	BTK(2), ELK1(2), FCER1A(2), GRB2(1), JUN(1), LYN(3), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(2), NFATC3(3), NFATC4(3), PAK2(1), PLA2G4A(6), PLCG1(4), PPP3CA(3), PPP3CB(2), RAF1(1), SHC1(1), SOS1(3), VAV1(1)	25273950	44	40	43	3	6	16	15	1	6	0	0.0056	0.14
25	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	40	IMPA1(1), INPP4A(2), INPP4B(3), INPP5B(4), INPPL1(1), IPMK(1), ITGB1BP3(1), ITPK1(1), MINPP1(1), OCRL(3), PI4KA(3), PI4KB(1), PIK3C3(2), PIK3CB(3), PIK3CG(2), PIP4K2A(1), PIP5K1A(1), PIP5K1C(3), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(2), PLCE1(5), PLCG1(4), PLCG2(2), PLCZ1(1), SYNJ2(1)	47556600	62	59	62	20	13	21	12	4	12	0	0.0058	0.14
26	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	52	ADH1A(1), ADH7(2), ADHFE1(1), ALDH3B1(2), ALDH3B2(2), AOC2(1), AOC3(2), AOX1(3), CARM1(1), DBH(4), DCT(2), DDC(1), ECH1(1), ESCO1(3), FAH(1), GOT2(1), GSTZ1(1), HPD(1), LCMT1(1), LCMT2(3), MAOA(2), METTL2B(2), MYST3(1), MYST4(5), PNPLA3(4), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1), TPO(6), TYR(3), TYRP1(2)	42266055	67	58	67	16	10	22	16	4	12	3	0.0059	0.14
27	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	29	ADH1A(1), ADH7(2), ADHFE1(1), ALDH3B1(2), ALDH3B2(2), AOC2(1), AOC3(2), AOX1(3), DBH(4), DCT(2), DDC(1), FAH(1), GOT2(1), GSTZ1(1), HPD(1), MAOA(2), TPO(6), TYR(3)	21981999	36	35	36	11	4	16	7	3	6	0	0.0064	0.14
28	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	71	B2M(2), CALR(1), CD4(1), CD74(1), CD8A(1), CIITA(3), CTSB(1), CTSS(1), HLA-C(3), HLA-DMA(1), HLA-DMB(2), HLA-DQB1(1), HLA-DRB1(2), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), HSP90AA1(2), HSP90AB1(2), IFNA10(1), IFNA14(1), IFNA2(2), IFNA4(1), KIR2DL3(1), KIR2DL4(1), KIR2DS4(1), KIR3DL2(4), KIR3DL3(1), KLRC1(3), KLRC2(1), KLRC3(1), NFYB(1), RFXANK(1), TAP1(1)	34670688	52	46	52	14	8	14	13	5	12	0	0.0065	0.14
29	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(1), CBR3(1), CYP4F2(1), EPX(1), GGT1(1), LPO(5), MPO(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PRDX1(1), PTGDS(1), PTGS2(1), TBXAS1(1), TPO(6)	19579833	33	31	31	1	5	11	9	3	5	0	0.0073	0.16
30	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH3B1(2), ALDH3B2(2), AOC2(1), AOC3(2), DDC(1), EPX(1), GOT2(1), HPD(1), LPO(5), MAOA(2), MPO(1), PRDX1(1), TPO(6)	15990273	26	26	26	5	4	8	4	3	7	0	0.0077	0.16
31	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), CFTR(6), GNAS(4), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(2)	8846136	18	18	18	3	5	3	5	1	4	0	0.0081	0.16
32	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CD3E(1), CD3G(1), ETV5(1), IL12A(1), IL12B(1), IL12RB1(2), IL18R1(1), JAK2(2), JUN(1), MAPK14(1), MAPK8(2), STAT4(5), TYK2(3)	13537407	22	21	21	7	3	3	7	1	8	0	0.0083	0.16
33	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(1)	3884127	9	9	9	0	2	5	1	0	1	0	0.0084	0.16
34	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	89	ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), ATF4(1), CACNA1C(4), CACNA1D(4), CACNA1F(6), CACNA1S(1), CAMK2A(1), CAMK2D(3), EGFR(4), ELK1(2), GNAQ(1), GNAS(4), GNRH2(1), GRB2(1), ITPR1(7), ITPR3(4), JUN(1), KRAS(1), LHB(1), MAP2K1(1), MAP2K3(1), MAP3K4(3), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MMP14(3), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PLD1(1), PRKACA(1), PTK2B(3), RAF1(1), SOS1(3), SOS2(1)	89699961	113	94	110	36	21	42	23	9	18	0	0.0088	0.16
35	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(3), BCAT2(2), COASY(3), DPYD(1), DPYS(1), ENPP1(3), ENPP3(2), ILVBL(2), PANK2(1), PANK4(1), UPB1(3), VNN1(1)	12231882	23	23	23	5	5	5	5	4	4	0	0.0088	0.16
36	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ACPP(1), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(1), CYP2C9(2), CYP2D6(2), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(2), CYP4F8(2), PON1(1)	21563217	41	36	40	8	7	12	11	4	7	0	0.011	0.18
37	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(3), AMY2A(1), ENPP1(3), ENPP3(2), GAA(2), GBE1(3), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(1), HK1(1), HK3(2), MGAM(8), PGM1(1), PGM3(1), PYGB(3), PYGL(1), PYGM(2), RNPC3(1), SI(4), UCHL3(1), UGT1A10(1), UGT1A6(2), UGT2B15(2), UGT2B4(1), UXS1(2)	41250534	58	54	58	16	11	15	16	6	10	0	0.011	0.19
38	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(1), CD3E(1), CD3G(1), CD4(1), CD8A(1), IL6(2), KITLG(2)	4662879	11	11	11	2	1	4	3	0	3	0	0.012	0.20
39	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3), GNAS(4), GNB1(1), PRKACA(1), PRKAR1A(1)	4388085	10	10	10	3	3	2	3	1	1	0	0.012	0.20
40	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	AKR1B1(2), B4GALT1(2), G6PC2(1), GAA(2), GALT(1), GANC(1), GCK(2), GLA(2), GLB1(1), HK1(1), HK3(2), LCT(3), MGAM(8), PFKM(3), PFKP(2), PGM1(1), PGM3(1), RDH11(2), RDH12(1), RDH14(1)	26363493	39	38	39	10	5	13	10	5	6	0	0.013	0.20
41	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(1), BRAF(2), C7orf16(1), CACNA1A(5), CRHR1(3), GNAI1(1), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(4), GRIA1(6), GRIA2(1), GRIA3(2), GRID2(2), GRM1(2), GRM5(1), GUCY1A2(2), GUCY2C(5), GUCY2D(1), GUCY2F(2), IGF1(1), IGF1R(1), ITPR1(7), ITPR3(4), KRAS(1), LYN(3), MAP2K1(1), MAPK1(1), MAPK3(1), NOS1(3), NOS3(2), NPR1(1), NPR2(2), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PPP2CB(2), PRKCG(1), PRKG1(1), PRKG2(4), RAF1(1), RYR1(5)	80529852	111	96	108	24	33	34	22	9	13	0	0.014	0.21
42	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(3), COASY(3), DPYD(1), DPYS(1), ENPP1(3), ENPP3(2), PANK2(1), PANK4(1), UPB1(3)	9672546	18	18	18	3	3	2	5	4	4	0	0.015	0.21
43	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(3), AR(3), ESR1(2), ESR2(2), HNF4A(2), NR1D1(1), NR1D2(1), NR1H2(3), NR2E1(1), NR4A1(1), NR4A2(1), NR5A2(4), PGR(2), PPARA(1), PPARG(1), RARA(1), RARB(4), RARG(2), ROR1(6), RORC(2), THRB(1)	29827317	44	42	44	16	12	14	6	0	10	2	0.015	0.21
44	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	61	AKT2(1), AKT3(2), BAD(1), KDR(2), KRAS(1), MAP2K1(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPKAPK3(1), NFAT5(1), NFATC3(3), NFATC4(3), NOS3(2), PIK3CB(3), PIK3CG(2), PIK3R3(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLCG1(4), PLCG2(2), PPP3CA(3), PPP3CB(2), PRKCG(1), PTGS2(1), PTK2(1), PXN(1), RAF1(1), SH2D2A(2), SPHK2(2)	44752890	60	51	58	15	9	21	16	6	8	0	0.015	0.21
45	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	94	ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), CAMK2A(1), CAMK2D(3), CREB3(1), CREB3L1(2), CREB3L2(2), CREB3L3(1), CREBBP(2), DCT(2), DVL3(1), EDN1(2), EDNRB(1), EP300(3), FZD1(1), FZD3(2), FZD6(2), FZD9(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(4), KIT(3), KITLG(2), KRAS(1), MAP2K1(1), MAPK1(1), MAPK3(1), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PRKACA(1), PRKCG(1), RAF1(1), TCF7(3), TCF7L2(1), TYR(3), TYRP1(2), WNT10B(1), WNT11(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT6(1), WNT8B(1), WNT9A(1)	73680282	94	80	93	37	25	32	21	4	12	0	0.016	0.22
46	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	20	AP2A1(3), AP2M1(2), ARF1(1), BAD(1), BTK(2), EEA1(1), GSK3A(1), LYN(3), PFKM(3), PFKP(2), PLCG1(4), PRKCZ(1)	16251885	24	24	24	9	6	7	3	2	6	0	0.017	0.23
47	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CD2(2), CD3E(1), CD3G(1), CD4(1), IL12A(1), IL12B(1), IL12RB1(2), JAK2(2), STAT4(5), TYK2(3)	10578555	19	18	18	5	3	2	7	1	6	0	0.018	0.23
48	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(2), EPOR(1), GRB2(1), JAK2(2), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PLCG1(4), RAF1(1), SHC1(1), SOS1(3), STAT5B(4)	15806232	25	24	25	2	2	10	4	1	8	0	0.018	0.23
49	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	100	ACTN2(4), ACTN3(1), ACTN4(4), ARHGAP5(3), CD99(2), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN6(1), CTNNA1(1), CTNNA2(2), CTNNA3(2), CTNND1(1), CYBB(1), ESAM(2), EZR(2), F11R(1), GNAI1(1), GNAI2(1), GRLF1(4), ITGA4(1), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(3), ITK(3), MAPK14(1), MMP9(1), MSN(1), MYL7(1), NCF2(2), NOX1(1), NOX3(1), PIK3CB(3), PIK3CG(2), PIK3R3(1), PLCG1(4), PLCG2(2), PRKCG(1), PTK2(1), PTK2B(3), PXN(1), RAPGEF3(2), RAPGEF4(2), RASSF5(1), RHOA(2), ROCK1(1), ROCK2(2), SIPA1(1), TXK(1), VAV1(1), VAV3(1), VCAM1(2), VCL(3)	83608863	93	86	93	38	22	26	17	5	23	0	0.020	0.25
50	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ACTG2(2), ADCY3(2), ADCY9(5), ARF1(1), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), ERO1L(2), GNAS(4), PDIA4(2), PLCG1(4), PLCG2(2), SEC61A1(1), TRIM23(2)	26759460	37	35	37	5	5	10	10	5	7	0	0.020	0.25
51	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), CD38(2), ENPP1(3), ENPP3(2), NMNAT1(1), NMNAT2(1), NNT(4), NT5E(3)	10647507	19	19	19	2	2	3	10	3	1	0	0.021	0.25
52	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), DDX20(2), E2F1(2), E2F4(2), ETS1(2), ETS2(3), ETV3(1), HDAC2(2), JUN(1), NCOR2(3), RBL1(1), RBL2(1), SIN3A(2), SIN3B(2)	17046354	26	26	26	9	6	5	7	2	6	0	0.021	0.25
53	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(3), ADCY8(2), ARAF(1), ATF4(1), BRAF(2), CACNA1C(4), CAMK2A(1), CAMK2D(3), CREBBP(2), EP300(3), GNAQ(1), GRIA1(6), GRIA2(1), GRIN1(1), GRIN2B(4), GRIN2C(4), GRIN2D(3), GRM1(2), GRM5(1), ITPR1(7), ITPR3(4), KRAS(1), MAP2K1(1), MAPK1(1), MAPK3(1), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PPP1R12A(1), PPP1R1A(1), PPP3CA(3), PPP3CB(2), PRKACA(1), PRKCG(1), RAF1(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3)	71536179	92	80	90	29	26	24	22	7	13	0	0.022	0.25
54	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3), CREM(1), FHL5(1), FSHR(3), GNAS(4), XPO1(2)	6646770	14	14	14	1	3	4	4	1	2	0	0.022	0.25
55	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	47	ACHE(2), AGPAT3(2), AGPS(1), CDS1(2), CLC(1), DGKA(3), DGKD(1), DGKE(1), DGKG(4), DGKH(1), ETNK1(3), GNPAT(1), GPD1(2), GPD2(1), LCAT(1), PAFAH1B1(1), PCYT1A(1), PCYT1B(2), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLCB2(2), PLCG1(4), PLCG2(2), PPAP2A(1)	34307169	50	46	47	9	7	17	11	9	6	0	0.022	0.25
56	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	EPX(1), LPO(5), MPO(1), PRDX1(1), TPO(6)	8287929	14	14	14	1	2	5	3	0	4	0	0.024	0.26
57	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(3), ELK1(2), GNAI1(1), GNAQ(1), GNAS(4), GNB1(1), JUN(1), MAP2K1(1), MAPK3(1), NFATC3(3), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CB(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAF1(1), RPS6KA3(2)	24281244	36	34	36	6	8	9	13	1	5	0	0.024	0.26
58	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), ADRA1A(1), ADRA1B(1), ANXA6(1), ARRB1(1), ATP1A4(5), ATP1B1(1), ATP2B1(4), ATP2B2(4), ATP2B3(4), CACNA1A(5), CACNA1B(1), CACNA1C(4), CACNA1D(4), CACNA1E(8), CACNA1S(1), CACNB1(1), CALR(1), CAMK1(1), CAMK2A(1), CAMK2D(3), CASQ2(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), GJA1(2), GJA4(1), GJB2(1), GJB3(2), GJB4(1), GJB5(1), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB3(2), GRK4(3), GRK6(1), ITPR1(7), ITPR3(4), KCNJ3(1), MIB1(2), NME7(2), PKIG(1), PLCB3(1), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), PRKD1(1), RGS1(1), RGS14(1), RGS17(2), RGS20(1), RGS3(2), RGS4(3), RGS5(1), RGS7(5), RGS9(2), RYR1(5), RYR2(13), RYR3(11), USP5(4), YWHAB(1)	139403706	175	130	175	79	43	52	44	8	24	4	0.025	0.26
59	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	147	ADORA1(1), ADORA3(1), ADRA1A(1), ADRA1B(1), AVPR1B(1), BDKRB1(2), BRS3(1), CCR3(1), CCR7(2), CCRL1(1), CHML(2), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CMKLR1(1), CNR1(1), CX3CR1(2), DRD2(1), DRD3(1), EDNRB(1), F2R(2), F2RL2(1), FPR1(1), FSHR(3), GALR1(2), GALR2(1), GALT(1), GHSR(1), GPR37(2), GPR50(2), GPR6(1), GPR63(1), GPR77(2), GPR83(3), GRPR(1), HCRTR1(1), HCRTR2(1), HRH2(2), HTR1A(1), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(3), LHCGR(4), MAS1(2), MC3R(2), MC4R(1), NMUR1(1), NMUR2(1), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(1), OPRK1(2), OPRM1(5), OR12D3(4), OR7A5(1), P2RY1(1), P2RY10(1), P2RY11(1), P2RY13(2), P2RY2(1), PTGDR(1), PTGFR(1), RHO(2), SSTR2(1), SSTR3(1)	82405752	110	96	109	40	18	40	25	11	16	0	0.025	0.26
60	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD2(2), CD33(1), CD5(2), IFNB1(1), IL12A(1), IL12B(1), ITGAX(2), TLR2(1), TLR4(7), TLR7(3)	14010945	24	21	23	7	5	6	4	1	8	0	0.025	0.26
61	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	ALDOB(2), ENO1(1), GPI(2), HK1(1), PGK1(2)	5463939	8	8	8	0	1	3	2	0	2	0	0.027	0.27
62	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), CHST1(1), CHST2(3), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	8156109	13	13	13	1	3	6	0	1	3	0	0.028	0.28
63	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ACTA2(1), ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), ARRB1(1), ATF3(1), ATF4(1), ATF5(2), CALCA(1), CAMK2A(1), CAMK2D(3), CORIN(1), CREB3(1), CRHR1(3), ETS2(3), GABPA(1), GJA1(2), GNAQ(1), GNB1(1), GNB3(2), GRK4(3), GRK6(1), IGFBP3(1), IL6(2), ITPR1(7), ITPR3(4), JUN(1), MIB1(2), NFKB1(1), NOS1(3), NOS3(2), PDE4B(2), PDE4D(3), PKIG(1), PLCB3(1), PLCD1(1), PLCG1(4), PLCG2(2), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCH(1), PRKCQ(2), PRKCZ(1), PRKD1(1), RAMP3(1), RGS1(1), RGS14(1), RGS17(2), RGS20(1), RGS3(2), RGS4(3), RGS5(1), RGS7(5), RGS9(2), RLN1(1), RYR1(5), RYR2(13), RYR3(11), SP1(1), TNXB(3), USP5(4), YWHAB(1)	127673754	151	122	151	64	35	43	42	6	25	0	0.029	0.28
64	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(3), ALDOB(2), G6PD(1), GPI(2), H6PD(2), PFKM(3), PFKP(2), PGD(2), PGLS(2), PGM1(1), PGM3(1), PRPS2(1), TKT(1)	14669031	23	23	23	4	7	5	3	4	4	0	0.029	0.28
65	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	64	A2M(3), BDKRB1(2), C2(1), C3(2), C4BPA(1), C4BPB(1), C5(3), C6(4), C7(3), C9(1), CD55(2), CFB(1), CFH(4), CPB2(1), CR1(6), CR2(2), F12(1), F13A1(3), F2(2), F2R(2), F5(7), F8(1), FGA(3), KLKB1(1), KNG1(1), MASP1(1), MASP2(1), MBL2(1), PLAT(1), PLAU(2), PLG(2), PROC(1), SERPINA1(1), SERPINA5(3), SERPINC1(2), SERPIND1(1), SERPINE1(1), TFPI(1), VWF(6)	66437787	82	75	81	25	11	27	21	12	11	0	0.029	0.28
66	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	65	AKT2(1), AKT3(2), BTK(2), FCER1A(2), GAB2(1), GRB2(1), INPP5D(2), KRAS(1), LAT(1), LCP2(1), LYN(3), MAP2K1(1), MAP2K3(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), PDK1(1), PIK3CB(3), PIK3CG(2), PIK3R3(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLCG1(4), PLCG2(2), RAF1(1), SOS1(3), SOS2(1), VAV1(1), VAV3(1)	45819618	58	52	56	11	9	26	10	5	8	0	0.030	0.28
67	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ALDH3B1(2), ALDH3B2(2), AOC2(1), AOC3(2), DDC(1), EPX(1), ESCO1(3), GOT2(1), HPD(1), LPO(5), MAOA(2), MPO(1), MYST3(1), MYST4(5), PNPLA3(4), TPO(6)	25210575	38	35	38	7	8	10	6	4	7	3	0.032	0.29
68	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(2), EGFR(4), ERBB3(8)	7630857	14	14	14	2	1	2	2	8	1	0	0.033	0.30
69	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), GAA(2), GALT(1), GCK(2), GLA(2), GLB1(1), HK1(1), HK3(2), LCT(3), MGAM(8), PFKM(3), PFKP(2), PGM1(1), PGM3(1)	22943778	33	32	33	10	5	11	7	5	5	0	0.036	0.32
70	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(3), CALCR(1), CALCRL(1), CD97(5), CRHR1(3), CRHR2(1), ELTD1(2), EMR1(2), EMR2(3), GHRHR(1), GIPR(1), GPR64(3), LPHN1(2), LPHN2(3), LPHN3(4)	19996080	35	31	35	10	4	8	10	4	6	3	0.036	0.32
71	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	122	ACTB(2), ACTG1(1), ACTN2(4), ACTN3(1), ACTN4(4), AKT2(1), AKT3(2), ASH1L(4), CASK(2), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN6(1), CRB3(1), CSNK2A1(1), CSNK2A2(1), CTNNA1(1), CTNNA2(2), CTNNA3(2), CTTN(1), EPB41(1), EPB41L1(4), EPB41L2(2), EPB41L3(3), EXOC3(1), EXOC4(1), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), IGSF5(3), INADL(5), KRAS(1), LLGL1(1), MAGI1(3), MAGI2(6), MAGI3(3), MPDZ(2), MYH1(4), MYH10(4), MYH11(5), MYH13(2), MYH14(5), MYH15(5), MYH2(1), MYH3(1), MYH4(4), MYH6(7), MYH7(6), MYH7B(5), MYH8(4), MYH9(5), MYL7(1), PARD3(3), PARD6B(1), PPP2CB(2), PPP2R3A(3), PPP2R4(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKCZ(1), RHOA(2), SPTAN1(2), SYMPK(3), TJP1(4), TJP3(2), VAPA(1), YES1(1), ZAK(1)	136536114	167	129	167	68	35	46	40	13	31	2	0.036	0.32
72	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	38	AKT2(1), AKT3(2), BRAF(2), EIF4B(1), FIGF(1), IGF1(1), MAPK1(1), MAPK3(1), PIK3CB(3), PIK3CG(2), PIK3R3(1), PRKAA2(2), RICTOR(3), RPS6(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3), RPS6KB2(3), TSC1(2), TSC2(2)	31169346	37	37	37	12	7	13	8	4	5	0	0.037	0.32
73	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	EGFR(4), ELK1(2), GNAS(4), GNB1(1), GRB2(1), IGF1R(1), ITGB1(2), KLK2(2), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), NGFR(1), PDGFRA(3), PTPRR(1), RAF1(1), RPS6KA1(1), SHC1(1), SOS1(3), STAT3(1)	23317944	33	33	33	6	4	13	9	4	3	0	0.038	0.32
74	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	12	AKT2(1), AKT3(2), ELK1(2), GRB2(1), MAP2K1(1), NGFR(1), NTRK1(1), SHC1(1), SOS1(3)	8720907	13	13	13	2	1	5	3	0	4	0	0.039	0.32
75	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(3), ALDOB(2), G6PD(1), GPI(2), H6PD(2), PFKM(3), PFKP(2), PGD(2), PGLS(2), PGM1(1), PGM3(1), PRPS2(1), TKT(1), TKTL1(1), TKTL2(1)	16685877	25	25	25	4	7	6	4	4	4	0	0.039	0.32
76	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	27	ADRA1A(1), ADRA1B(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), DRD2(1), DRD3(1), HRH2(2), HTR1A(1), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(3)	16994640	26	25	26	10	9	8	3	0	6	0	0.040	0.32
77	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(4), ASH2L(3), CARM1(1), CTCFL(1), DOT1L(3), EED(2), EZH1(1), HCFC1(5), KDM6A(5), MEN1(1), MLL(5), MLL2(6), MLL4(4), MLL5(4), OGT(2), PRDM2(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1), RBBP5(1), SATB1(2), SETD2(4), SETD7(1), SETDB1(7), SETMAR(2), SMYD3(3), SUV420H1(2), SUZ12(3), WHSC1(4), WHSC1L1(1)	78945984	85	76	84	15	15	23	16	8	23	0	0.040	0.32
78	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	65	CDS1(2), DGKA(3), DGKD(1), DGKE(1), DGKG(4), DGKH(1), DGKI(5), IMPA1(1), INPP4A(2), INPP4B(3), INPP5B(4), INPP5D(2), INPPL1(1), ITGB1BP3(1), ITPK1(1), ITPR1(7), ITPR3(4), OCRL(3), PI4KA(3), PI4KB(1), PIK3C2A(2), PIK3C2B(2), PIK3C2G(1), PIK3C3(2), PIK3CB(3), PIK3CG(2), PIK3R3(1), PIP4K2A(1), PIP5K1A(1), PIP5K1C(3), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(2), PLCE1(5), PLCG1(4), PLCG2(2), PLCZ1(1), PRKCG(1), SYNJ2(1)	84134622	97	87	96	35	20	30	19	9	19	0	0.040	0.32
79	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	22	CSNK2A1(1), EGF(2), EGFR(4), ELK1(2), GRB2(1), JAK1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PLCG1(4), RAF1(1), RASA1(2), SHC1(1), SOS1(3), SRF(1), STAT1(1), STAT3(1)	22293804	30	29	30	2	3	9	6	5	7	0	0.041	0.32
80	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), DRD2(1), EGF(2), EGFR(4), GJA1(2), GNAI1(1), GNAI2(1), GNAQ(1), GNAS(4), GRB2(1), GRM1(2), GRM5(1), GUCY1A2(2), GUCY2C(5), GUCY2D(1), GUCY2F(2), HTR2A(3), HTR2B(1), HTR2C(1), ITPR1(7), ITPR3(4), KRAS(1), MAP2K1(1), MAP2K5(1), MAPK1(1), MAPK3(1), NPR1(1), NPR2(2), PDGFB(1), PDGFRA(3), PDGFRB(2), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PRKACA(1), PRKCG(1), PRKG1(1), PRKG2(4), RAF1(1), SOS1(3), SOS2(1), TJP1(4), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2B(1), TUBB2C(2), TUBB4(1)	95638452	114	93	113	36	26	41	20	10	17	0	0.041	0.32
81	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	AGXT(1), AGXT2(1), ALAS2(1), AMT(1), AOC2(1), AOC3(2), BHMT(1), CBS(1), CTH(1), DAO(1), DLD(1), DMGDH(3), GARS(1), GATM(3), GCAT(2), MAOA(2), PLCB2(2), PLCG1(4), PLCG2(2), SARDH(2), SARS(2), TARS(4)	29933280	39	37	39	17	7	16	6	2	8	0	0.043	0.32
82	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	35	ACTA2(1), ACTN2(4), ACTN3(1), ACTN4(4), DMD(11), MYBPC1(2), MYBPC2(1), MYBPC3(1), MYH3(1), MYH6(7), MYH7(6), MYH8(4), MYL1(1), MYOM1(2), NEB(13), TMOD1(1), TNNC2(1), TNNI3(1), TPM1(2), TPM2(1), TPM3(1), TTN(77)	104159094	143	112	143	25	26	35	45	13	20	4	0.044	0.33
83	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	66	ACACB(8), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(2), AKT2(1), AKT3(2), CAMKK1(3), CAMKK2(2), CD36(1), CPT1A(2), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(2), IRS1(1), IRS4(1), JAK1(1), JAK2(2), JAK3(1), LEPR(3), MAPK10(1), MAPK8(2), NFKB1(1), NFKB2(4), NPY(1), PCK1(1), PCK2(1), PPARA(1), PPARGC1A(1), PRKAA2(2), PRKAB1(1), PRKAG2(1), PRKAG3(2), PRKCQ(2), RELA(1), SLC2A4(1), STAT3(1), TNFRSF1A(1), TYK2(3)	58829238	67	59	66	19	13	25	8	4	14	3	0.045	0.33
84	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR1(2), ESR2(2), PDE1A(2), PDE1B(1), PLCB1(3), PLCB2(2), VIP(1)	7870668	13	13	13	2	9	2	1	0	1	0	0.046	0.34
85	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(1), BTK(2), CD79A(1), ELK1(2), GRB2(1), JUN(1), LYN(3), MAP2K1(1), MAPK14(1), MAPK3(1), MAPK8(2), NFATC3(3), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CB(2), RAF1(1), SHC1(1), SOS1(3), VAV1(1)	25648116	37	35	37	5	3	15	12	0	7	0	0.047	0.34
86	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(1), LPO(5), MPO(1), TPO(6)	8250918	13	13	13	1	2	5	3	0	3	0	0.048	0.34
87	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	89	AKT2(1), AKT3(2), CASP8(2), CD14(1), CD40(1), CD86(1), IFNA10(1), IFNA14(1), IFNA2(2), IFNA4(1), IFNAR2(1), IFNB1(1), IKBKB(2), IKBKE(1), IL12A(1), IL12B(1), IL6(2), IRAK1(1), IRAK4(2), IRF3(1), JUN(1), LBP(1), MAP2K1(1), MAP2K3(1), MAP3K8(2), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(1), NFKB2(4), PIK3CB(3), PIK3CG(2), PIK3R3(1), RELA(1), RIPK1(3), SPP1(1), STAT1(1), TICAM1(2), TIRAP(2), TLR1(1), TLR2(1), TLR3(1), TLR4(7), TLR5(1), TLR7(3), TLR8(2), TRAF6(1)	59575035	76	68	75	17	12	24	12	5	20	3	0.049	0.34
88	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MAX(1), MYC(1), SP1(1), SP3(3), WT1(1)	4496583	9	9	9	2	1	2	2	1	3	0	0.049	0.34
89	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	24	CRKL(1), GNAQ(1), GRB2(1), JUN(1), MAP2K1(1), MAP2K3(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(4), PTK2B(3), RAF1(1), SHC1(1), SOS1(3)	16846089	25	24	25	3	4	10	5	1	5	0	0.050	0.34
90	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(3), CAMK2A(1), CAMK2D(3), CDK5(1), F2(2), GNAI1(1), GNB1(1), GRB2(1), JAK2(2), MAP2K1(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPT(1), MYLK(5), PLCG1(4), PTK2B(3), RAF1(1), SHC1(1), SOS1(3), STAT1(1), STAT3(1)	30070170	41	39	41	11	6	17	8	2	8	0	0.050	0.34
91	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(3), ALDOB(2), GCK(2), GMDS(2), HK1(1), HK3(2), KHK(1), PFKFB1(1), PFKFB3(1), PFKFB4(1), PFKM(3), PFKP(2)	17381988	23	23	23	4	4	11	2	2	4	0	0.050	0.34
92	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	122	ALCAM(1), CADM1(1), CD2(2), CD22(1), CD226(2), CD274(1), CD276(1), CD34(1), CD4(1), CD40(1), CD40LG(1), CD86(1), CD8A(1), CD99(2), CDH2(1), CDH4(2), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN6(1), CNTN1(4), CNTN2(4), CNTNAP1(3), CNTNAP2(3), ESAM(2), F11R(1), GLG1(2), HLA-C(3), HLA-DMA(1), HLA-DMB(2), HLA-DQB1(1), HLA-DRB1(2), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), ICOSLG(1), ITGA4(1), ITGA6(3), ITGA8(2), ITGAL(1), ITGAM(1), ITGAV(3), ITGB1(2), ITGB2(3), ITGB8(1), L1CAM(1), MAG(1), MPZL1(1), NCAM1(4), NCAM2(2), NEO1(3), NFASC(4), NLGN1(1), NLGN3(3), NRCAM(1), NRXN1(1), NRXN2(3), NRXN3(5), PTPRC(1), PTPRF(3), PTPRM(2), PVRL1(1), PVRL2(3), PVRL3(1), SDC4(1), SELE(1), SELL(4), SELP(3), SELPLG(1), SIGLEC1(1), SPN(2), VCAM1(2), VCAN(7)	104504361	141	103	140	42	36	32	35	11	27	0	0.051	0.34
93	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	CYP2C18(2), CYP2C19(1), CYP2C8(1), CYP2C9(2), CYP3A4(3), CYP3A7(4), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), RDH11(2), RDH12(1), RDH14(1)	17358159	30	27	28	6	5	8	7	4	6	0	0.054	0.36
94	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(1), ACP6(1), ACPP(1), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP3A4(3), CYP3A7(4), DHRS2(2), DHRS7(1), PON1(1), PON3(1)	12883377	25	20	24	6	6	6	6	3	4	0	0.058	0.38
95	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), CD38(2), ENPP1(3), ENPP3(2), NADK(1), NMNAT1(1), NMNAT2(1), NNT(4), NT5C1B(3), NT5C3(1), NT5E(3)	15745899	24	24	24	3	4	4	12	3	1	0	0.059	0.38
96	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(3), F2(2), F2R(2), FGA(3), PLAT(1), PLAU(2), PLG(2), SERPINE1(1)	10074597	17	17	17	5	3	7	3	3	1	0	0.059	0.38
97	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	21	GHR(2), GRB2(1), INSR(2), IRS1(1), JAK2(2), MAP2K1(1), MAPK1(1), MAPK3(1), PLCG1(4), RAF1(1), RPS6KA1(1), SHC1(1), SLC2A4(1), SOS1(3), SRF(1), STAT5B(4)	21266115	27	26	27	5	1	11	6	2	7	0	0.060	0.38
98	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	13	AKT2(1), AKT3(2), GRB2(1), ILK(2), MAPK1(1), MAPK3(1), PDK1(1), PTK2B(3), RBL2(1), SHC1(1), SOS1(3)	11770005	17	16	17	1	2	7	4	0	4	0	0.060	0.38
99	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), CHPT1(1), LCMT1(1), LCMT2(3), METTL2B(2), PCYT1A(1), PCYT1B(2), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1)	10125297	19	16	19	3	2	6	6	1	4	0	0.063	0.39
100	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(4), PTK2B(3)	5011695	8	8	8	0	3	2	1	0	2	0	0.065	0.39
101	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), AGT(3), EDN1(2), EDNRB(1), EGF(2), EGFR(4), JUN(1), MYC(1), NFKB1(1), PLCG1(4), RELA(1)	15368184	21	21	21	4	5	6	1	5	4	0	0.065	0.39
102	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	24	AKT2(1), AKT3(2), GRB2(1), IARS(5), IL13RA1(1), IL2RG(1), INPP5D(2), JAK1(1), JAK2(2), JAK3(1), NR0B2(2), PI3(1), SERPINA4(3), SHC1(1), SOS1(3), SOS2(1), TYK2(3)	24823734	31	30	30	7	2	11	9	1	8	0	0.066	0.39
103	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(1), DHRS2(2), DHRS7(1), LCMT1(1), LCMT2(3), METTL2B(2), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1)	10633311	18	16	18	4	3	4	6	1	4	0	0.066	0.39
104	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(1), CD4(1), HLA-DRB1(2), IL5RA(1), IL6(2)	4083885	8	8	8	3	0	3	1	1	3	0	0.068	0.40
105	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	70	ABL1(2), AKT2(1), AKT3(2), ARHGEF6(1), ARHGEF7(2), BRAF(2), CAV1(1), CSE1L(2), EPHB2(1), GRB2(1), GRB7(3), GRLF1(4), ILK(2), ITGA1(3), ITGA10(1), ITGA11(4), ITGA2(2), ITGA4(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGB3BP(1), MAP3K11(1), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1), MYLK(5), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PIK3CB(3), PLCG1(4), PLCG2(2), PTK2(1), RAF1(1), RHO(2), ROCK1(1), ROCK2(2), SHC1(1), SOS1(3), SOS2(1), TERF2IP(2), TLN1(7), TLN2(4), WAS(1)	84128538	97	80	97	33	16	31	17	9	24	0	0.068	0.40
106	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), GCH1(1)	4283643	9	8	8	2	2	2	3	1	1	0	0.071	0.40
107	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(3), GNAS(4), PLCE1(5), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAP2B(1)	10122762	16	16	16	4	5	4	3	1	3	0	0.071	0.40
108	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	37	CREBBP(2), DTX1(3), DTX2(1), DTX4(1), DVL3(1), EP300(3), HDAC1(2), HDAC2(2), JAG1(1), MAML1(1), MAML2(1), MAML3(1), NCOR2(3), NCSTN(1), NOTCH2(4), NOTCH3(3), NOTCH4(6), NUMB(1), NUMBL(3), PSEN2(2), PTCRA(1), RBPJL(3), SNW1(2)	42009006	48	43	46	17	11	12	9	2	12	2	0.072	0.40
109	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(1), GNB1(1), HTR2C(1), PLCB1(3), TUB(2)	5256069	10	10	10	1	4	4	2	0	0	0	0.073	0.40
110	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(2), ATM(9), BRCA1(8), CHEK2(2), JUN(1), MAPK8(2), MDM2(1), NFKB1(1), RAD50(1), RELA(1)	21037458	28	26	28	3	1	8	2	4	13	0	0.073	0.40
111	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	16	ADCY1(3), ARHGEF1(5), F2(2), F2R(2), GNAI1(1), GNAQ(1), GNB1(1), PLCB1(3), PTK2B(3), ROCK1(1)	15810795	22	22	22	3	9	6	3	2	2	0	0.074	0.40
112	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	21	CSNK2A1(1), ELK1(2), GRB2(1), JAK1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PDGFRA(3), PLCG1(4), RAF1(1), RASA1(2), SHC1(1), SOS1(3), SRF(1), STAT1(1), STAT3(1)	20131956	27	26	27	2	4	8	7	1	7	0	0.074	0.40
113	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACAA1(1), ACOX1(2), ACOX3(1), ELOVL5(2), ELOVL6(2), FADS2(4), SCD(1)	7883850	13	13	13	4	0	3	4	4	2	0	0.075	0.41
114	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	72	ACTB(2), ACTG1(1), ACTN2(4), ACTN3(1), ACTN4(4), ACVR1B(4), ACVR1C(1), BAIAP2(1), CREBBP(2), CSNK2A1(1), CSNK2A2(1), CTNNA1(1), CTNNA2(2), CTNNA3(2), CTNND1(1), EGFR(4), EP300(3), ERBB2(4), FARP2(3), IGF1R(1), INSR(2), IQGAP1(1), MAPK1(1), MAPK3(1), MET(4), NLK(1), PARD3(3), PTPRB(2), PTPRF(3), PTPRJ(1), PTPRM(2), PVRL1(1), PVRL2(3), PVRL3(1), RHOA(2), SMAD2(3), SMAD3(2), SMAD4(1), SNAI1(1), SNAI2(1), SORBS1(4), SSX2IP(1), TCF7(3), TCF7L2(1), TGFBR1(2), TJP1(4), VCL(3), WAS(1), WASF1(1), WASF3(1), WASL(1), YES1(1)	84569121	102	90	101	35	25	26	16	7	25	3	0.080	0.43
115	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(3), CAPN2(2), EGF(2), EGFR(4), ITGA1(3), ITGB1(2), MAPK1(1), MAPK3(1), MYLK(5), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTK2(1), PXN(1), TLN1(7)	24248796	35	33	35	12	5	13	6	8	3	0	0.083	0.45
116	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	33	ACTN2(4), ACTN3(1), BCR(1), CAPN1(3), CAV1(1), CRKL(1), GRB2(1), ITGA1(3), ITGB1(2), JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(2), PTK2(1), PXN(1), RAF1(1), ROCK1(1), SHC1(1), SOS1(3), TLN1(7), VCL(3)	32807463	41	40	41	12	3	13	13	2	10	0	0.084	0.45
117	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	61	ACHE(2), AGPAT3(2), AGPAT6(1), CDS1(2), CHPT1(1), DGKA(3), DGKD(1), DGKE(1), DGKG(4), DGKH(1), DGKI(5), ESCO1(3), ETNK1(3), ETNK2(1), GNPAT(1), GPD1(2), GPD1L(1), GPD2(1), LCAT(1), MYST3(1), MYST4(5), PCYT1A(1), PCYT1B(2), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLD1(1), PNPLA3(4), PPAP2A(1), PTDSS2(1)	45749145	65	57	62	13	12	20	13	10	7	3	0.086	0.45
118	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(1), IDI1(2), SQLE(1)	2398617	5	5	5	3	2	2	0	0	1	0	0.087	0.45
119	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	17	B2M(2), ITGB1(2), KLRC1(3), KLRC2(1), KLRC3(1), LAT(1), MAP2K1(1), MAPK3(1), PAK1(2), PTK2B(3), VAV1(1)	10603398	18	18	18	2	5	4	4	2	3	0	0.087	0.45
120	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	27	CAV1(1), CHRM1(2), CHRNA1(1), FLT1(2), FLT4(1), KDR(2), NOS3(2), PDE2A(3), PDE3A(6), PDE3B(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKG1(1), PRKG2(4), RYR2(13)	27675609	42	39	42	23	12	12	10	5	3	0	0.087	0.45
121	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	62	ATP8A1(2), AVPR1B(1), BDKRB1(2), BRS3(1), CCR3(1), CCR7(2), CX3CR1(2), EDNRB(1), FPR1(1), FSHR(3), GALR1(2), GALR2(1), GALT(1), GHSR(1), GPR77(2), GRPR(1), LHCGR(4), MC2R(1), MC3R(2), MC4R(1), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(1), OPRK1(2), OPRM1(5), SSTR2(1), SSTR3(1), TACR2(1), TSHR(3)	35717643	51	48	51	21	5	22	11	7	6	0	0.088	0.45
122	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(2), EGFR(4), MAP2K1(1), MAPK14(1), NCOR2(3), RARA(1), THRB(1)	9140703	13	13	13	4	3	3	1	4	2	0	0.089	0.45
123	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	17	BCR(1), CRKL(1), GRB2(1), JAK2(2), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), MYC(1), RAF1(1), SOS1(3), STAT1(1), STAT5B(4)	13967343	20	20	20	2	0	8	4	1	7	0	0.090	0.45
124	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	23	ARHGDIB(1), BAG4(1), CASP2(2), CASP8(2), DFFB(2), JUN(1), LMNB1(1), MADD(7), MAPK8(2), PAK1(2), PAK2(1), PRKDC(7), RIPK1(3), SPTAN1(2), TNFRSF1A(1)	24696477	35	32	35	5	6	14	5	3	7	0	0.095	0.47
125	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	18	CSNK2A1(1), ELK1(2), GRB2(1), INSR(2), IRS1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), RAF1(1), RASA1(2), SHC1(1), SLC2A4(1), SOS1(3), SRF(1)	15665286	21	21	21	4	1	7	7	1	5	0	0.098	0.48
126	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	74	AKT2(1), AKT3(2), APAF1(1), ATM(9), BAD(1), CAPN1(3), CAPN2(2), CASP6(1), CASP8(2), CSF2RB(2), DFFB(2), FAS(1), FASLG(1), IKBKB(2), IL1A(1), IL1R1(1), IL1RAP(2), IL3RA(1), IRAK1(1), IRAK2(2), IRAK3(1), IRAK4(2), NFKB1(1), NFKB2(4), NTRK1(1), PIK3CB(3), PIK3CG(2), PIK3R3(1), PPP3CA(3), PPP3CB(2), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RELA(1), RIPK1(3), TNFRSF10D(1), TNFRSF1A(1)	54965391	68	57	68	12	12	25	10	6	12	3	0.099	0.49
127	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(3), CSF1(2), IL6R(1), SELL(4), SPN(2), TNFRSF1A(1), TNFRSF8(1)	9757722	14	14	13	4	4	2	3	2	3	0	0.10	0.49
128	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	38	CD3E(1), CD3G(1), ELK1(2), GRB2(1), JUN(1), LAT(1), MAP2K1(1), MAPK3(1), MAPK8(2), NFATC3(3), NFATC4(3), NFKB1(1), PLCG1(4), PPP3CA(3), PPP3CB(2), PTPN7(1), RAF1(1), RASA1(2), RELA(1), SHC1(1), SOS1(3), VAV1(1), ZAP70(1)	29283813	38	36	38	6	4	12	14	0	8	0	0.10	0.49
129	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(1), CYP11B1(2), CYP11B2(3), CYP17A1(1), CYP21A2(2), HSD3B2(2)	6722313	12	12	12	1	4	3	4	1	0	0	0.10	0.49
130	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(1), CYP11B1(2), CYP11B2(3), CYP17A1(1), CYP21A2(2), HSD3B2(2)	6722313	12	12	12	1	4	3	4	1	0	0	0.10	0.49
131	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT2(2), FUT3(2), ST3GAL3(1)	3254940	5	5	4	0	3	0	0	0	2	0	0.11	0.49
132	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	AGXT(1), AGXT2(1), ALAS2(1), AMT(1), AOC2(1), AOC3(2), BHMT(1), CBS(1), CTH(1), DAO(1), DLD(1), DMGDH(3), GARS(1), GATM(3), GCAT(2), MAOA(2), PIPOX(1), RDH11(2), RDH12(1), RDH14(1), SARDH(2), SARS(2), SARS2(2), TARS(4), TARS2(2)	30761211	40	38	40	20	7	16	8	2	7	0	0.11	0.49
133	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ACPP(1), ACPT(2), ENPP1(3), ENPP3(2), TYR(3)	7215117	12	12	12	4	2	4	3	2	1	0	0.11	0.50
134	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(1), ELK1(2), GRB2(1), IGF1(1), IGF1R(1), IRS1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), RAF1(1), RASA1(2), SHC1(1), SOS1(3), SRF(1)	15312414	20	20	20	3	2	6	7	0	5	0	0.11	0.50
135	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	103	ALG1(1), ALG10(1), ALG10B(3), ALG11(1), ALG13(2), ALG2(1), ALG6(1), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), C1GALT1(1), C1GALT1C1(1), CHPF(1), CHST1(1), CHST11(1), CHST2(3), CHST3(1), DPAGT1(2), EXT1(3), EXT2(2), EXTL3(3), FUT11(1), GALNT10(2), GALNT11(3), GALNT13(1), GALNT3(1), GALNT4(1), GALNT5(2), GALNT7(2), GALNTL1(1), GALNTL5(1), GCNT4(1), HS2ST1(1), HS3ST2(1), HS3ST5(3), HS6ST2(3), HS6ST3(1), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT3(1), MGAT5(2), MGAT5B(4), NDST3(1), OGT(2), RPN1(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(2), UST(1), WBSCR17(4), XYLT2(1)	78611871	88	79	88	39	22	25	17	6	18	0	0.11	0.50
136	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	9	GRB2(1), KLK2(2), NTRK1(1), PLCG1(4), SHC1(1), SOS1(3)	8013135	12	11	12	1	2	4	3	0	3	0	0.11	0.50
137	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(3), AMY2A(1), ASCC3(1), ATP13A2(1), DDX41(1), DDX50(3), DDX55(3), DDX56(1), DHX58(2), ENPP1(3), ENPP3(2), ENTPD7(1), ERCC3(2), G6PC2(1), GAA(2), GANC(1), GBE1(3), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(1), HK1(1), HK3(2), IFIH1(1), MGAM(8), NUDT8(1), PGM1(1), PGM3(1), PYGB(3), PYGL(1), PYGM(2), RAD54B(4), RAD54L(2), SETX(6), SI(4), SKIV2L2(1), SMARCA2(3), SMARCA5(1), TREH(1), UGT1A10(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B15(2), UGT2B28(1), UGT2B4(1), UXS1(2)	89551410	97	86	97	21	20	24	27	10	16	0	0.11	0.51
138	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	CDK5(1), EGR1(1), KLK2(2), MAP2K1(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1)	5585112	9	9	9	2	0	5	2	1	1	0	0.11	0.51
139	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	13	ACHE(2), DBH(4), DDC(1), GAD1(2), GAD2(3), MAOA(2), PAH(1)	9864699	15	15	15	1	3	5	5	0	2	0	0.12	0.51
140	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT5(1), FUT2(2), FUT3(2), ST3GAL3(1), ST3GAL4(1)	5462925	8	8	7	0	3	2	1	0	2	0	0.12	0.51
141	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	31	AKT2(1), AKT3(2), BRAF(2), DRD2(1), EGFR(4), EPHB2(1), GRB2(1), ITPR1(7), ITPR3(4), KCNJ3(1), MAPK1(1), PI3(1), PIK3CB(3), PITX2(1), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), RAF1(1), RGS20(1), SHC1(1), SOS1(3), SOS2(1), STAT3(1), TERF2IP(2)	41365116	52	47	52	11	10	18	9	5	10	0	0.12	0.51
142	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), B3GALT5(1), FUT2(2), GLA(2), HEXB(1), ST3GAL1(1), ST8SIA1(1)	7540104	9	9	8	1	2	0	3	1	3	0	0.12	0.51
143	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(2), F2R(2), F5(7), FGA(3), PROC(1), SERPINC1(2), TFPI(1)	11751246	18	18	18	6	2	6	2	5	3	0	0.12	0.51
144	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(2), GALNT3(1), GALNT4(1), GALNT7(2), ST3GAL1(1), ST3GAL4(1), WBSCR17(4)	10584639	12	12	12	6	2	3	2	0	5	0	0.12	0.51
145	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	9	B2M(2), CD3E(1), CD3G(1), ITGAL(1), ITGB2(3), PRF1(2)	5646459	10	10	10	3	2	4	2	0	2	0	0.12	0.51
146	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(9), ATR(2), BRCA1(8), CCNB1(2), CDC25B(3), CHEK2(2), EP300(3), MDM2(1), PRKDC(7), RPS6KA1(1)	31400031	38	35	37	6	4	13	5	4	12	0	0.12	0.51
147	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(3)	1383603	3	3	3	1	1	1	0	0	1	0	0.12	0.51
148	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	20	GRIN1(1), GRIN2B(4), GRIN2C(4), GRIN2D(3), NOS1(3), PPP3CA(3), PPP3CB(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	15904590	23	23	22	7	9	5	7	2	0	0	0.12	0.51
149	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), AKAP1(1), AKAP11(5), AKAP12(2), AKAP3(2), AKAP6(3), AKAP8(1), AKAP9(7), ARHGEF1(5), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB3(2), ITPR1(7), KCNJ3(1), KRAS(1), PDE1A(2), PDE1B(1), PDE4A(1), PDE4B(2), PDE4C(3), PDE4D(3), PLCB3(1), PPP3CA(3), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKCZ(1), PRKD1(1), RHOA(2), USP5(4)	85302243	91	81	91	36	22	23	25	8	13	0	0.13	0.51
150	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	118	ARAF(1), BRAF(2), CD244(1), FAS(1), FASLG(1), GRB2(1), HLA-C(3), HLA-E(2), HLA-G(2), IFNA10(1), IFNA14(1), IFNA2(2), IFNA4(1), IFNAR2(1), IFNB1(1), ITGAL(1), ITGB2(3), KIR2DL3(1), KIR2DL4(1), KIR3DL2(4), KLRC1(3), KLRC2(1), KLRC3(1), KLRK1(2), KRAS(1), LAT(1), LCP2(1), MAP2K1(1), MAPK1(1), MAPK3(1), NCR2(1), NFAT5(1), NFATC3(3), NFATC4(3), PAK1(2), PIK3CB(3), PIK3CG(2), PIK3R3(1), PLCG1(4), PLCG2(2), PPP3CA(3), PPP3CB(2), PRF1(2), PRKCG(1), PTK2B(3), RAF1(1), SH3BP2(1), SHC1(1), SHC3(1), SHC4(2), SOS1(3), SOS2(1), TNFRSF10D(1), ULBP3(2), VAV1(1), VAV3(1), ZAP70(1)	77065521	93	80	93	30	17	28	27	5	16	0	0.13	0.51
151	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1), CD3G(1)	864942	2	2	2	0	0	1	1	0	0	0	0.13	0.51
152	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	21	ATM(9), BMPR1B(2), DMC1(2), EGR1(1), ESR2(2), FSHR(3), GJA4(1), LHCGR(4), PGR(2), PRLR(1), ZP2(1)	21383232	28	26	28	9	2	10	3	5	8	0	0.13	0.51
153	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(2), C5(3), C6(4), C7(3), IL1A(1), IL6(2), ITGA4(1), ITGAL(1), ITGB1(2), ITGB2(3), SELP(3), SELPLG(1), VCAM1(2)	17954898	28	25	28	6	8	5	6	4	5	0	0.13	0.51
154	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(1), HLA-DRB1(2)	2298231	4	4	4	1	0	1	1	1	1	0	0.13	0.51
155	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	26	EGR2(1), EGR3(3), GNAQ(1), MYC(1), NFKB1(1), PLCG1(4), PPP3CA(3), PPP3CB(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RELA(1), VIP(1)	17589858	21	21	21	6	5	6	3	1	6	0	0.13	0.51
156	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(3), IARS(5), LARS2(2), PDHA1(1), PDHA2(1), PDHB(1)	7556328	13	12	13	4	2	5	4	0	2	0	0.13	0.51
157	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	30	AKT2(1), AKT3(2), ARHGEF11(1), LPA(5), MAP3K5(1), MAPK8(2), NFKB1(1), NFKB2(4), PDK1(1), PHKA2(4), PI3(1), PIK3CB(3), PLD1(1), PLD3(1), PTK2(1), RDX(1), ROCK1(1), ROCK2(2), SERPINA4(3), SRF(1)	32231511	37	31	37	7	7	13	5	1	8	3	0.13	0.51
158	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	30	AGT(3), EGFR(4), ELK1(2), GNAQ(1), GRB2(1), JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(1), MEF2C(2), PAK1(2), PTK2(1), PTK2B(3), RAF1(1), SHC1(1), SOS1(3)	21853728	31	29	31	4	4	12	6	4	5	0	0.13	0.51
159	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	18	BAD(1), CASP8(2), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(1), NSMAF(2), RAF1(1), RELA(1), RIPK1(3), TNFRSF1A(1)	12243543	17	17	16	3	1	8	4	0	4	0	0.13	0.51
160	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	549588	1	1	1	1	0	0	0	0	1	0	0.13	0.51
161	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F12(1), F2(2), F5(7), F8(1), FGA(3), LPA(5), PLAT(1), PLAU(2), PLG(2), SERPINE1(1), VWF(6)	25646088	31	31	30	12	3	12	7	5	4	0	0.13	0.51
162	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	20	ABAT(3), ADSL(1), AGXT(1), AGXT2(1), ASL(3), ASPA(1), CAD(7), CRAT(3), DARS(1), GAD1(2), GAD2(3), GOT2(1), GPT2(2), NARS(1), PC(1)	18343767	31	28	31	4	7	13	5	3	3	0	0.14	0.51
163	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CDO1(1), GAD1(2), GAD2(3), GGT1(1)	4305951	8	8	8	0	2	3	3	0	0	0	0.14	0.51
164	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	15	ABCB1(3), ATM(9), CPB2(1), IGFBP3(1), MAPK8(2), MDM2(1), NQO1(1)	13550082	18	17	18	8	0	7	4	2	5	0	0.14	0.52
165	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT2(2), GLA(2), HEXB(1), ST3GAL1(1), ST3GAL4(1), ST8SIA1(1)	7070115	8	8	7	1	2	1	2	0	3	0	0.14	0.52
166	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(2), ALDOA(3), ALDOB(2), FUK(2), GMDS(2), HK1(1), HK3(2), KHK(1), MTMR6(1), PFKFB1(1), PFKFB3(1), PFKFB4(1), PFKM(3), PFKP(2), RDH11(2), RDH12(1), RDH14(1)	25502100	28	27	28	8	4	11	4	3	6	0	0.14	0.53
167	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12A(1), IL12B(1), IL2(1)	2321046	4	4	4	1	0	0	2	1	1	0	0.14	0.53
168	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(1), GRB2(1), JAK2(2), JUN(1), MAP2K1(1), MAPK3(1), PLCG1(4), RAF1(1), RASA1(2), SHC1(1), SOS1(3), STAT1(1), STAT3(1), STAT5B(4)	19420128	24	23	24	2	2	8	4	1	9	0	0.15	0.54
169	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	20	IMPA1(1), INPP4A(2), INPP4B(3), INPPL1(1), OCRL(3), PIK3C2A(2), PIK3C2B(2), PIK3C2G(1), PIK3CB(3), PIK3CG(2), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCG1(4), PLCG2(2)	30269421	39	37	39	10	8	14	9	1	7	0	0.15	0.56
170	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	16	GNAQ(1), JUN(1), MAPK14(1), MAPK8(2), PLCG1(4), PTK2B(3)	9682686	12	12	12	2	3	4	1	0	4	0	0.16	0.57
171	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), GNAS(4), GNB1(1), PRKAA2(2), PRKAB1(1), PRKAG2(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	10483239	15	15	15	6	6	3	3	1	2	0	0.16	0.57
172	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	12	ECHS1(1), EHHADH(2), HADH(1), HSD17B10(1), HSD17B4(3), NTAN1(1), VNN2(3)	8264100	12	12	12	5	2	2	6	1	1	0	0.16	0.57
173	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(1), ELK1(2), GRB2(1), IL6(2), IL6R(1), IL6ST(3), JAK1(1), JAK2(2), JAK3(1), JUN(1), MAP2K1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(3), SRF(1), STAT3(1)	17464629	24	23	24	3	1	6	7	3	7	0	0.16	0.57
174	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(1), HADH(1), HADHB(1), HSD17B10(1), HSD17B4(3), PPT2(1)	6138756	9	9	9	3	3	2	1	2	1	0	0.16	0.58
175	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(2), ATM(9), CCNA2(2), CCNB1(2), CCNB3(3), CCND3(5), CDC25B(3), CDC7(1), CDK2(1), CHEK2(2), DTX4(1), E2F1(2), E2F3(1), E2F4(2), EP300(3), ESPL1(6), HDAC1(2), HDAC2(2), HDAC3(1), HDAC6(2), HDAC8(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(1), ORC2L(1), ORC3L(1), PLK1(1), PRKDC(7), PTPRA(1), RBL1(1), SMAD4(1), TBC1D8(1)	79405326	78	68	77	19	13	20	12	7	23	3	0.17	0.58
176	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(3), EDN1(2), EP300(3), JUN(1), NOS3(2)	11883066	13	13	12	4	4	1	1	1	6	0	0.17	0.58
177	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	4	PLCB1(3), PLCG1(4), VAV1(1)	6064227	8	8	8	1	3	3	0	0	2	0	0.17	0.58
178	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	28	CD14(1), ELK1(2), IKBKB(2), IRAK1(1), JUN(1), MAP2K3(1), MAPK14(1), MAPK8(2), NFKB1(1), PPARA(1), RELA(1), TIRAP(2), TLR10(1), TLR2(1), TLR3(1), TLR4(7), TLR7(3), TRAF6(1)	23883756	30	28	29	5	4	12	4	0	10	0	0.17	0.58
179	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	33	ACTG1(1), ACTG2(2), FLNA(4), FLNC(8), FSCN3(1), GDI1(3), LIMK1(3), MYH2(1), MYLK(5), PAK1(2), PAK2(1), PAK3(1), PAK7(1), RHO(2), ROCK1(1), ROCK2(2), RPS4X(1), WASF1(1), WASL(1)	33217119	41	41	41	15	8	14	8	4	7	0	0.17	0.58
180	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	53	BMP2(2), BMP4(2), BMP5(1), BMP6(1), BMP8B(1), CSNK1A1L(2), CSNK1E(1), DHH(1), GLI1(2), GLI2(2), GLI3(3), LRP2(17), PRKACA(1), PTCH1(3), SMO(2), SUFU(2), WNT10B(1), WNT11(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT6(1), WNT8B(1), WNT9A(1), ZIC2(1)	41887833	53	48	53	21	12	19	10	8	4	0	0.17	0.58
181	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	13	BAIAP2(1), CASP1(1), CASP8(2), INSR(2), MAGI1(3), MAGI2(6), RERE(1), WWP2(4)	15389478	20	20	20	7	6	5	4	1	4	0	0.17	0.58
182	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	30	ABAT(3), ADC(1), ALDH5A1(1), CAD(7), CPS1(2), EARS2(3), EPRS(2), GAD1(2), GAD2(3), GCLC(1), GCLM(1), GFPT2(3), GLS(1), GLUD2(1), GMPS(1), GNPNAT1(1), GOT2(1), GPT2(2), GSS(1), NAGK(1), PPAT(1), QARS(2)	28367664	41	37	41	5	7	11	17	3	3	0	0.17	0.58
183	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(6), CR2(2), HLA-DRB1(2), ITGAL(1), ITGB2(3), PTPRC(1)	11272638	15	15	15	7	3	2	5	4	1	0	0.17	0.58
184	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	62	ADAM10(1), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), EGFR(4), F11R(1), GIT1(1), IGSF5(3), IKBKB(2), JUN(1), LYN(3), MAPK10(1), MAPK14(1), MAPK8(2), MET(4), NFKB1(1), NFKB2(4), NOD1(3), PAK1(2), PLCG1(4), PLCG2(2), PTPRZ1(4), RELA(1), TCIRG1(1), TJP1(4)	50063208	60	53	60	11	9	16	8	10	11	6	0.17	0.58
185	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(2), C5(3), C6(4), C7(3), C9(1)	9174165	13	13	13	3	2	4	3	2	2	0	0.17	0.58
186	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(8), CARM1(1), CCND1(1), CREBBP(2), EP300(3), ERCC3(2), ESR1(2), HDAC1(2), HDAC2(2), HDAC3(1), HDAC6(2), MEF2C(2), NCOR2(3), POLR2A(2), TBP(1)	32082453	34	32	33	9	7	5	7	1	14	0	0.18	0.58
187	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ITGA4(1), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(3), SELE(1), SELL(4), SELP(3)	12912783	16	16	16	2	4	1	5	3	3	0	0.18	0.58
188	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	GNAQ(1), NFATC3(3), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CB(2), SP1(1), SP3(3)	14787669	20	18	20	3	2	4	9	0	5	0	0.18	0.58
189	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	19	CCNB1(2), CCND1(1), CCND3(5), CDK2(1), CDK6(1), CDK7(1), E2F1(2), RBL1(1)	9736428	14	12	14	3	4	2	1	2	2	3	0.18	0.58
190	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	14	GRB2(1), MAPK1(1), MAPK3(1), MEF2A(1), MEF2C(2), NTRK1(1), PLCG1(4), RPS6KA1(1), SHC1(1)	10272327	13	12	13	2	3	5	1	0	4	0	0.18	0.58
191	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(1), SNAP25(1)	2437656	4	4	4	1	1	1	1	1	0	0	0.18	0.58
192	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(2), LRP8(1), RELN(10), VLDLR(2)	10596300	16	16	15	3	4	5	4	0	3	0	0.18	0.58
193	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	88	AKT2(1), AKT3(2), CARD11(2), CBLB(7), CBLC(3), CD3E(1), CD3G(1), CD4(1), CD40LG(1), CD8A(1), GRB2(1), IKBKB(2), IL2(1), ITK(3), JUN(1), KRAS(1), LAT(1), LCP2(1), MALT1(1), MAP3K8(2), NFAT5(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKB2(4), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PDK1(1), PIK3CB(3), PIK3CG(2), PIK3R3(1), PLCG1(4), PPP3CA(3), PPP3CB(2), PRKCQ(2), PTPRC(1), RHOA(2), SOS1(3), SOS2(1), TEC(1), VAV1(1), VAV3(1), ZAP70(1)	68649828	80	66	80	24	14	24	21	7	11	3	0.18	0.58
194	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT3(2), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH1B3(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PLD1(1), PPAP2A(1)	16270137	25	23	23	3	5	6	7	5	2	0	0.19	0.58
195	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN2(4), ACTN3(1), CAPN1(3), ITGA1(3), ITGB1(2), ITGB3(2), PTK2(1), PXN(1), SPTAN1(2), TLN1(7)	21083595	26	26	26	8	2	9	9	2	4	0	0.19	0.58
196	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(2), GABRA3(3), GABRA6(3), SOD1(1)	5944068	9	9	9	4	2	5	2	0	0	0	0.19	0.58
197	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	9	ANPEP(3), FBL(2), LDHC(1), MAPK14(1), NCL(1)	6315699	8	8	8	1	2	4	1	0	1	0	0.19	0.58
198	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	10	GRB2(1), ILK(2), ITGB1(2), MAPK1(1), MAPK3(1), PDK2(1), PTK2(1), SHC1(1), SOS1(3)	8977956	13	13	13	3	1	6	3	1	2	0	0.19	0.58
199	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(1), ATM(9), CCND1(1), CDK2(1), E2F1(2), MDM2(1)	11280750	15	14	15	1	2	5	2	1	5	0	0.19	0.58
200	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(2), B4GALT3(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	5528328	7	7	7	0	2	2	0	1	2	0	0.19	0.58
201	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH7(2), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH3B1(2), ALDH3B2(2), ALDH9A1(1), ALDOA(3), ALDOB(2), DLD(1), ENO1(1), ENO3(1), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(3), PFKP(2), PGK1(2), PGM1(1), PGM3(1)	35244612	42	39	42	10	6	21	5	7	3	0	0.19	0.58
202	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH7(2), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH3B1(2), ALDH3B2(2), ALDH9A1(1), ALDOA(3), ALDOB(2), DLD(1), ENO1(1), ENO3(1), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(3), PFKP(2), PGK1(2), PGM1(1), PGM3(1)	35244612	42	39	42	10	6	21	5	7	3	0	0.19	0.58
203	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(2), IL6(2), LDLR(1), LPL(1)	3979443	7	7	7	5	2	2	1	0	2	0	0.19	0.58
204	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	18	B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(1), FUT2(2), FUT3(2), ST3GAL6(1), ST8SIA1(1)	10440651	13	13	12	2	6	1	1	2	3	0	0.19	0.58
205	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	77	BRAF(2), ELK1(2), GRB2(1), IKBKB(2), JUN(1), MAP2K1(1), MAP2K3(1), MAP2K5(1), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(3), MAP3K4(3), MAP3K5(1), MAP3K6(1), MAP3K8(2), MAP3K9(1), MAP4K1(1), MAP4K4(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK4(2), MAPK6(1), MAPK8(2), MAPKAPK3(1), MAX(1), MEF2A(1), MEF2C(2), MYC(1), NFKB1(1), PAK1(2), PAK2(1), RAF1(1), RELA(1), RIPK1(3), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KB2(3), SHC1(1), SP1(1), STAT1(1), TGFB3(1), TGFBR1(2)	65066859	70	66	70	12	12	25	11	4	18	0	0.20	0.58
206	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(1), CAMK1G(1), CAMK2A(1), CAMK2D(3), CAMKK1(3), CAMKK2(2)	8115042	11	11	11	5	2	2	4	0	3	0	0.20	0.58
207	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(2), F2R(2), GNAI1(1), GNB1(1), ITGA1(3), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), PLA2G4A(6), PLCB1(3), PTK2(1), RAF1(1), TBXAS1(1)	17665908	26	24	25	5	5	10	7	4	0	0	0.20	0.58
208	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(3), CAP1(2), CCNB1(2), GNAI1(1), GNAS(4), GNB1(1), MAPK1(1), MAPK3(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1)	13810173	19	18	19	5	5	6	4	2	2	0	0.20	0.58
209	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	122	ABL1(2), ARHGEF12(2), CDK5(1), DCC(6), DPYSL2(1), DPYSL5(1), EFNA3(1), EFNB1(1), EFNB2(1), EPHA1(2), EPHA2(2), EPHA3(2), EPHA4(1), EPHA5(5), EPHA6(2), EPHA7(2), EPHB1(2), EPHB2(1), EPHB3(1), EPHB4(1), EPHB6(2), FES(1), GNAI1(1), GNAI2(1), ITGB1(2), KRAS(1), L1CAM(1), LIMK1(3), LIMK2(1), MAPK1(1), MAPK3(1), MET(4), NFAT5(1), NFATC3(3), NFATC4(3), NGEF(2), NRP1(3), NTNG1(2), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PLXNA1(3), PLXNA2(4), PLXNA3(3), PLXNB1(1), PLXNC1(1), PPP3CA(3), PPP3CB(2), PTK2(1), RASA1(2), RGS3(2), RHOA(2), ROBO1(2), ROBO2(3), ROCK1(1), ROCK2(2), SEMA3A(2), SEMA3B(1), SEMA3C(1), SEMA3D(1), SEMA3E(1), SEMA3F(1), SEMA4A(1), SEMA4F(5), SEMA4G(1), SEMA5A(3), SEMA5B(2), SEMA6A(1), SEMA7A(1), SLIT1(1), SLIT2(2), SLIT3(1), SRGAP1(5), SRGAP3(1), UNC5B(1), UNC5C(3), UNC5D(6)	136224816	148	120	148	44	34	47	33	8	23	3	0.20	0.58
210	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD3E(1), CD3G(1), CD86(1), GRB2(1), HLA-DRB1(2), IL2(1), ITK(3)	6799884	10	10	10	6	0	5	3	2	0	0	0.20	0.59
211	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(5), GNAQ(1), GNB1(1), MYLK(5), PLCB1(3), ROCK1(1)	15472119	19	19	19	5	5	9	1	1	3	0	0.20	0.59
212	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(1), HK3(2), IMPA1(1), PGM1(1), PGM3(1), TGDS(2)	7469631	10	10	10	2	1	4	2	2	1	0	0.20	0.60
213	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(3), G6PD(1), GCLC(1), GCLM(1), GGT1(1), GPX5(1), GSS(1), GSTA1(1), GSTA4(1), GSTO2(1), GSTZ1(1), IDH1(1), PGD(2)	13306722	16	16	16	2	5	3	6	0	2	0	0.21	0.61
214	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1B(2), BMPR2(2)	4549818	5	5	4	3	1	1	0	0	3	0	0.21	0.61
215	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	AKT2(1), AKT3(2), BAD(1), BTK(2), GRB2(1), GSK3A(1), IARS(5), INPP5D(2), PDK1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(3), SOS2(1), TEC(1), YWHAB(1)	23669295	28	26	28	6	5	10	7	2	4	0	0.21	0.61
216	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(1), IDI1(2), SQLE(1)	3217422	5	5	5	4	2	2	0	0	1	0	0.22	0.61
217	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(2), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(1), RELA(1), TNFRSF11A(2), TRAF6(1)	8257002	11	11	11	3	3	4	1	1	2	0	0.22	0.61
218	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	23	ADCY1(3), CAMK2A(1), CAMK2D(3), GNAS(4), GRB2(1), MAPK1(1), MAPK14(1), MAPK3(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1), SOS1(3)	16741647	22	22	22	8	5	8	5	1	3	0	0.22	0.62
219	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2	FAH(1), GSTZ1(1)	983073	2	2	2	1	0	2	0	0	0	0	0.22	0.62
220	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	10	BAD(1), CHRNB1(2), CHRNG(1), MUSK(3), PTK2(1), PTK2B(3)	7925424	11	11	10	2	6	2	3	0	0	0	0.22	0.62
221	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA2(2), CCND1(1), CDK2(1), E2F1(2), E2F4(2)	5806671	8	8	8	0	2	1	2	0	3	0	0.22	0.62
222	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(5), DYRK1B(1), GLI2(2), GLI3(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), SMO(2), SUFU(2)	11675703	18	16	18	8	4	5	4	4	1	0	0.22	0.62
223	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), CNDP1(2), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), HIBCH(2), MLYCD(2), UPB1(3)	19599099	27	25	27	8	2	9	9	3	4	0	0.22	0.62
224	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT2(1), TYR(3)	3468894	5	5	5	2	1	3	1	0	0	0	0.23	0.62
225	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), KHK(1), LCT(3), PGM1(1), PYGL(1), PYGM(2), TREH(1)	9918441	10	10	10	0	0	3	0	2	5	0	0.23	0.62
226	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(4), GNB1(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	6444477	9	9	9	3	3	2	2	1	1	0	0.23	0.62
227	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(1), HLA-DRB1(2)	1837368	3	3	3	2	0	1	1	1	0	0	0.23	0.62
228	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(3), ACADSB(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), CNDP1(2), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), MLYCD(2), UPB1(3)	21314787	29	27	29	10	2	12	7	4	4	0	0.23	0.62
229	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(2), SULT1E1(2), SUOX(3)	4623840	7	7	7	2	1	4	1	0	1	0	0.23	0.62
230	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(1), NDUFA1(1), SDHA(1), SDHB(1), UQCRC1(2)	4941729	7	7	7	3	0	2	1	3	1	0	0.23	0.62
231	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(4), GAD1(2)	3937869	6	6	6	1	1	2	2	0	1	0	0.23	0.62
232	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(2)	1530126	3	3	3	1	1	1	1	0	0	0	0.23	0.62
233	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	17	APAF1(1), ATM(9), BAD(1), CASP6(1), EIF2S1(1), PTK2(1), PXN(1), STAT1(1), TLN1(7)	18963321	23	21	23	2	2	7	3	2	9	0	0.24	0.62
234	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(1), PTPRU(5), STAT1(1), STAT2(1), TYK2(3)	9173151	12	12	11	5	2	3	3	2	2	0	0.24	0.62
235	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), GRB2(1), IL3RA(1), JAK2(2), MAP2K1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(3), STAT5B(4)	12693759	17	17	17	2	1	7	3	1	5	0	0.24	0.63
236	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(1)	1601106	3	3	3	0	2	0	1	0	0	0	0.24	0.63
237	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(3), ALDOB(2)	2934009	5	5	5	0	1	3	0	1	0	0	0.24	0.63
238	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA1(2), GABRA3(3), GABRA6(3), GPHN(1), UBQLN1(1)	8917116	12	12	12	4	2	7	1	1	1	0	0.24	0.63
239	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(3), SNCAIP(2)	4594434	7	7	7	2	2	2	2	1	0	0	0.25	0.63
240	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	101	ABL1(2), ANAPC1(1), ANAPC5(4), ANAPC7(1), ATM(9), ATR(2), CCNA2(2), CCNB1(2), CCNB3(3), CCND1(1), CCND3(5), CDC23(1), CDC25B(3), CDC27(1), CDC7(1), CDK2(1), CDK6(1), CDK7(1), CHEK2(2), CREBBP(2), CUL1(1), E2F1(2), E2F3(1), EP300(3), ESPL1(6), HDAC1(2), HDAC2(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(1), ORC2L(1), ORC3L(1), PLK1(1), PRKDC(7), RBL1(1), RBL2(1), SMAD2(3), SMAD3(2), SMAD4(1), SMC1A(2), SMC1B(2), TGFB3(1), YWHAB(1)	97961526	96	82	95	18	15	28	17	9	24	3	0.25	0.63
241	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	9	GCK(2), HK1(1), HK3(2), IMPA1(1), PGM1(1), PGM3(1), TGDS(2)	7846839	10	10	10	2	1	4	2	2	1	0	0.25	0.63
242	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(1), AASDHPPT(2), AASS(3)	5207904	6	6	6	3	0	2	2	0	2	0	0.25	0.63
243	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	BAD(1), BRAF(2), CREB3(1), DUSP6(1), DUSP9(1), EEF2K(2), GRB2(1), MAP2K1(1), MAP3K8(2), MAPK1(1), MAPK3(1), MOS(2), NFKB1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(3), SOS2(1)	21150519	27	27	27	4	6	9	8	1	3	0	0.25	0.63
244	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(3), ALDOB(2), DLD(1), ENO1(1), ENO3(1), GCK(2), GOT2(1), GPI(2), HK1(1), HK3(2), LDHC(1), MDH2(2), PC(1), PCK1(1), PDHA1(1), PDHA2(1), PDHB(1), PDHX(1), PFKM(3), PFKP(2), PGK1(2)	29427801	32	31	32	7	6	15	4	4	3	0	0.26	0.64
245	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(1), IL22RA1(1), IL22RA2(1), JAK1(1), JAK2(2), JAK3(1), STAT1(1), STAT3(1), STAT5B(4), TYK2(3)	13375674	17	16	16	3	2	4	4	2	5	0	0.26	0.64
246	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	17	EXT1(3), EXT2(2), EXTL3(3), GLCE(2), HS2ST1(1), HS3ST2(1), HS3ST5(3), HS6ST2(3), HS6ST3(1), NDST3(1)	14650272	20	19	20	7	3	5	7	1	4	0	0.26	0.64
247	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(1), CYP11B2(3), CYP17A1(1), HSD3B2(2)	5218551	8	8	8	1	4	2	1	1	0	0	0.26	0.65
248	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	27	CD4(1), CSF1(2), HLA-DRB1(2), IFNB1(1), IL12A(1), IL12B(1), IL15(1), IL1A(1), IL2(1), IL6(2), TGFB3(1)	9781044	14	13	14	6	4	2	3	2	3	0	0.26	0.65
249	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(2), AASS(3)	3507933	5	5	5	3	0	2	2	0	1	0	0.26	0.65
250	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ITGA4(1), ITGAL(1), ITGB1(2), ITGB2(3), SELE(1), SELL(4)	9914385	12	12	12	2	2	1	4	3	2	0	0.27	0.65
251	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	12	BAD(1), GRB2(1), IGF1R(1), IRS1(1), MAP2K1(1), MAPK1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(3)	10434567	12	12	12	3	2	5	3	0	2	0	0.27	0.65
252	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP5(3), ARHGAP6(1), ARHGEF1(5), ARHGEF11(1), ARPC1A(1), ARPC1B(1), ARPC2(2), BAIAP2(1), GSN(1), LIMK1(3), MYLK(5), OPHN1(2), PIP5K1A(1), ROCK1(1), TLN1(7), VCL(3)	34057725	38	34	38	17	7	10	7	3	11	0	0.27	0.65
253	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	21	APC(3), AXIN1(1), CCND1(1), CD14(1), FZD1(1), GJA1(2), GNAI1(1), IRAK1(1), LBP(1), NFKB1(1), RELA(1), TIRAP(2), TLR4(7)	17396691	23	22	22	9	4	6	8	1	4	0	0.27	0.66
254	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3), PNPO(2)	3425799	5	5	5	1	0	2	2	0	1	0	0.27	0.66
255	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	35	CAMK1(1), CAMK1G(1), ELK1(2), FPR1(1), GNB1(1), MAP2K1(1), MAP2K3(1), MAPK1(1), MAPK14(1), MAPK3(1), NCF2(2), NFATC3(3), NFATC4(3), NFKB1(1), PAK1(2), PIK3C2G(1), PLCB1(3), PPP3CA(3), PPP3CB(2), RAF1(1), RELA(1)	25428585	33	32	33	10	6	11	13	1	2	0	0.27	0.66
256	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	16	ACY1(2), ALDH18A1(1), ARG1(2), ARG2(1), ASL(3), CKMT2(1), CPS1(2), GATM(3)	11416119	15	15	15	3	2	7	4	1	1	0	0.27	0.66
257	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(1), CD8A(1), CSF1(2), IL2(1), IL6(2)	4508751	7	7	7	2	1	2	2	0	2	0	0.27	0.66
258	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	C1GALT1(1), C1GALT1C1(1), GALNT10(2), GALNT11(3), GALNT13(1), GALNT3(1), GALNT4(1), GALNT5(2), GALNT7(2), GALNTL1(1), GALNTL5(1), GCNT4(1), OGT(2), ST3GAL1(1), ST6GALNAC1(2), WBSCR17(4)	23704785	26	24	26	11	9	5	4	2	6	0	0.28	0.66
259	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ABAT(3), ACAT1(1), ACSM1(1), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), HADH(1), HMGCS1(1), HMGCS2(1), HSD17B10(1), HSD17B4(3), ILVBL(2), L2HGDH(1), OXCT1(1), OXCT2(1), PDHA1(1), PDHA2(1), PDHB(1), PLA1A(2), RDH11(2), RDH12(1), RDH14(1)	29395353	38	36	38	14	8	11	13	3	3	0	0.28	0.66
260	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYB(1), SP1(1), SP3(3)	3665610	5	5	5	2	0	0	2	0	3	0	0.28	0.66
261	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	47	ADORA3(1), ALG6(1), CCR3(1), CELSR2(1), CELSR3(4), CHRM2(2), CHRM3(1), EMR2(3), EMR3(2), F2R(2), FSHR(3), GHRHR(1), GPR132(1), GPR133(1), GPR143(2), GPR56(1), GPR77(2), GPR84(2), GRM1(2), GRPR(1), HRH4(1), LGR6(2), LPHN2(3), LPHN3(4), LTB4R2(1), P2RY11(1), P2RY13(2), PTGFR(1), SMO(2), SSTR2(1), TAAR5(3), TSHR(3)	42664557	58	51	58	12	12	22	14	5	5	0	0.28	0.66
262	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A13(4), CYP2A6(1), CYP2A7(1), XDH(3)	6075381	9	9	9	1	3	2	3	1	0	0	0.29	0.67
263	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	47	AGT(3), CALR(1), CAMK1(1), CAMK1G(1), CREBBP(2), EDN1(2), F2(2), IGF1(1), LIF(3), MAP2K1(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MEF2C(2), MYH2(1), NFATC3(3), NFATC4(3), NPPA(1), PPP3CA(3), PPP3CB(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAF1(1)	32408454	41	38	41	12	6	13	12	5	5	0	0.29	0.67
264	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	ACY1(2), ADC(1), AGMAT(1), ALDH18A1(1), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(2), ARG1(2), ARG2(1), ASL(3), ASS1(1), CPS1(2), GATM(3), MAOA(2), SAT1(1), SAT2(1)	21234681	27	27	27	5	3	13	7	1	3	0	0.29	0.67
265	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS2(2), ABAT(3), ADSL(1), AGXT(1), AGXT2(1), ASL(3), ASPA(1), ASS1(1), CAD(7), CRAT(3), DARS(1), DARS2(1), DLD(1), GAD1(2), GAD2(3), GOT2(1), GPT2(2), NARS(1), NARS2(1), PC(1), PDHA1(1), PDHA2(1), PDHB(1)	26791908	40	35	40	6	7	17	9	4	3	0	0.29	0.68
266	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(3), CPS1(2), GLS(1)	5560776	8	8	8	0	1	3	2	1	1	0	0.29	0.68
267	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ITGAL(1), ITGAM(1), ITGB2(3), SELE(1), SELL(4)	8792901	10	10	10	1	2	1	3	1	3	0	0.30	0.69
268	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	18	ADCY1(3), GNAI1(1), GNB1(1), ITGAV(3), ITGB3(2), MAPK1(1), MAPK3(1), PDGFRA(3), PLCB1(3), PTK2(1), SMPD2(2)	16273686	21	21	21	4	7	8	5	0	1	0	0.30	0.69
269	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), MST1(3)	4472247	5	5	5	0	1	1	1	1	1	0	0.30	0.69
270	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CDC25B(3), CDK7(1), MNAT1(1), XPO1(2)	6424704	9	9	9	3	2	3	1	2	1	0	0.31	0.69
271	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(3), AGT(3), KNG1(1), NOS3(2)	6494670	9	9	9	2	3	2	2	0	2	0	0.31	0.69
272	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(3), BCAT2(2), IARS(5), IARS2(2), ILVBL(2), LARS2(2), PDHA1(1), PDHA2(1), PDHB(1)	13871013	19	18	19	6	5	8	4	0	2	0	0.31	0.69
273	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	31	CRKL(1), ELK1(2), GAB1(1), GRB2(1), HGF(3), ITGA1(3), ITGB1(2), JUN(1), MAP2K1(1), MAP4K1(1), MAPK1(1), MAPK3(1), MAPK8(2), MET(4), PAK1(2), PTK2(1), PTK2B(3), PXN(1), RAF1(1), RASA1(2), SOS1(3), STAT3(1)	29294460	38	34	38	5	4	14	11	2	4	3	0.31	0.69
274	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(2), GRB2(1), IL2(1), IL2RG(1), JAK1(1), JAK3(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(3), STAT5B(4)	17205552	22	21	22	6	1	9	5	2	5	0	0.31	0.69
275	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(1), CD3G(1), CD4(1), CREBBP(2), GNAS(4), GNB1(1), HLA-DRB1(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTPRC(1), ZAP70(1)	15967458	20	20	20	8	6	4	5	3	2	0	0.31	0.69
276	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(1), CD3G(1), CD4(1), CREBBP(2), GNAS(4), GNB1(1), HLA-DRB1(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTPRC(1), ZAP70(1)	15967458	20	20	20	8	6	4	5	3	2	0	0.31	0.69
277	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(9), CDC25B(3), CDK2(1)	11165661	13	12	13	3	0	5	0	3	5	0	0.31	0.69
278	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(1), MBTPS1(1), MBTPS2(1), SCAP(3), SREBF2(3)	7526922	10	10	10	6	2	3	2	2	1	0	0.31	0.69
279	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CD3E(1), CD3G(1), CD4(1)	1925586	3	3	3	1	0	2	1	0	0	0	0.31	0.69
280	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	42	ACOX1(2), CD36(1), CITED2(1), CREBBP(2), EHHADH(2), EP300(3), FABP1(1), HSD17B4(3), JUN(1), LPL(1), MAPK1(1), MAPK3(1), MYC(1), NCOA1(1), NCOR2(3), NR0B2(2), PPARA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTGS2(1), RELA(1), SP1(1), STAT5B(4)	35687223	37	37	36	12	6	11	7	4	9	0	0.31	0.69
281	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	33	AKT2(1), AKT3(2), BAD(1), BCR(1), BLNK(1), BTK(2), CD19(1), EPHB2(1), GRB2(1), LYN(3), MAP2K1(1), MAPK1(1), NFAT5(1), NFKB1(1), NFKB2(4), PI3(1), PLCG2(2), RAF1(1), SERPINA4(3), SHC1(1), SOS1(3), SOS2(1), VAV1(1)	32062173	35	33	35	5	4	17	6	0	5	3	0.32	0.69
282	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(7), MAP2(7), PRKAR2A(1), PRKAR2B(1)	13720941	16	16	16	6	2	5	0	7	2	0	0.32	0.70
283	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	46	ADCY4(1), ADCY8(2), CACNA1A(5), CACNA1B(1), GNAS(4), GNB1(1), GNB3(2), GRM4(1), ITPR3(4), PDE1A(2), PLCB2(2), PRKACA(1), TAS1R1(1), TAS1R2(1), TAS2R1(1), TAS2R10(1), TAS2R13(1), TAS2R14(1), TAS2R16(2), TAS2R3(1), TAS2R43(3), TAS2R46(1), TAS2R8(1), TAS2R9(2)	40245660	42	39	42	24	7	13	9	4	9	0	0.32	0.70
284	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(9), CDC25B(3)	10220106	12	11	12	3	0	5	0	3	4	0	0.32	0.70
285	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(1), APC(3), AXIN1(1), BMP10(1), BMP2(2), BMP4(2), BMP5(1), BMPR2(2), CHRD(2), FZD1(1), MEF2C(2), NPPA(1), RFC1(2), TGFB3(1), TGFBR1(2), TGFBR3(2)	25249107	26	25	25	16	2	13	4	3	4	0	0.32	0.70
286	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	19	ADCY1(3), BAD(1), CSF2RB(2), IGF1(1), IGF1R(1), IL3RA(1), KIT(3), KITLG(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	11951511	17	16	17	4	8	3	4	1	1	0	0.33	0.70
287	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(1), CBS(1), CTH(1), GGT1(1), LCMT1(1), LCMT2(3), MAT2B(1), METTL2B(2), PAPSS1(2), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1), SEPHS1(1)	17718636	23	20	23	7	2	10	7	0	4	0	0.33	0.71
288	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	22	BCR(1), BLNK(1), ELK1(2), GRB2(1), JUN(1), LYN(3), MAP2K1(1), MAPK1(1), MAPK3(1), PAPPA(4), RPS6KA1(1), RPS6KA3(2), SHC1(1), SOS1(3), VAV1(1), VAV3(1)	18977010	25	24	25	3	4	13	6	0	2	0	0.33	0.71
289	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(2), CS(1), HAO1(3), HAO2(1), MDH2(2), MTHFD1(4), MTHFD1L(1)	9514869	15	13	15	2	4	6	3	1	1	0	0.33	0.71
290	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACYP1(1), ECHS1(1), EHHADH(2), GCDH(1), SDHB(1)	5613504	7	7	7	5	0	2	3	2	0	0	0.34	0.72
291	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	20	GNAI1(1), GNAQ(1), GNB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), NFKB1(1), PIK3C2G(1), PLCG1(4), PTK2(1), PTK2B(3), PXN(1), RAF1(1), RELA(1)	16904394	19	18	19	2	4	7	5	0	3	0	0.34	0.72
292	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	CHST11(1), PAPSS1(2), SULT1A1(1), SULT1E1(2), SUOX(3)	6736002	9	9	9	5	2	4	2	0	1	0	0.34	0.72
293	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), HSD17B1(1), HSD17B2(1), HSD17B4(3), HSD3B2(2)	6020625	8	8	8	1	4	1	1	1	1	0	0.34	0.72
294	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(1), EPHB1(2), ITGA1(3), ITGB1(2), L1CAM(1), LYN(3), SELP(3)	12027054	15	15	15	4	4	6	4	1	0	0	0.34	0.72
295	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	17	CCND1(1), CDK2(1), CDK6(1), E2F1(2), MAPK1(1), MAPK3(1), NFKB1(1), PAK1(2), RAF1(1), RELA(1)	9607143	12	12	12	1	3	4	2	1	2	0	0.35	0.72
296	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(9), ATR(2), CHEK2(2)	11535264	13	12	13	2	0	6	1	2	4	0	0.35	0.72
297	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	64	ACAA1(1), ACOX1(2), ACOX3(1), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(2), APOA5(1), AQP7(2), CD36(1), CPT1A(2), CPT1C(2), CPT2(1), CYP27A1(1), CYP8B1(1), EHHADH(2), FABP1(1), FABP2(1), FABP4(1), FABP6(1), FADS2(4), GK2(1), HMGCS2(1), ILK(2), LPL(1), PCK1(1), PCK2(1), PLTP(1), PPARA(1), PPARG(1), SCD(1), SLC27A2(1), SLC27A4(2), SLC27A5(2), SORBS1(4)	46939074	50	46	50	18	7	15	11	5	12	0	0.35	0.72
298	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS2(2), DHRS7(1), PON1(1), PON3(1), RDH11(2), RDH12(1), RDH14(1)	6518499	9	8	9	3	2	1	2	1	3	0	0.35	0.73
299	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(3), ACAA1(1), ACAA2(1), ACAT1(1), ALDH1B1(1), ALDH9A1(1), AOX1(3), BCAT1(3), BCAT2(2), BCKDHA(1), DLD(1), ECHS1(1), EHHADH(2), HADH(1), HADHB(1), HIBCH(2), HMGCS1(1), HMGCS2(1), HSD17B10(1), HSD17B4(3), MCCC1(2), OXCT1(1), OXCT2(1), PCCA(1)	31026879	36	36	36	11	5	14	12	2	3	0	0.35	0.73
300	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACOT11(2), ACYP1(1), DHRS2(2), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(3), GCDH(1), ITGB1BP3(1), MYST3(1), MYST4(5), PNPLA3(4)	19064214	25	22	25	8	6	4	6	4	2	3	0.35	0.73
301	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ACP6(1), ACPP(1), ACPT(2), ENPP1(3), ENPP3(2), MTMR6(1), TYR(3)	11073894	14	14	14	4	3	4	4	2	1	0	0.35	0.73
302	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(2), IL6R(1), JAK1(1), JAK2(2), JAK3(1), PTPRU(5), STAT3(1)	11162112	13	13	13	6	1	4	0	2	6	0	0.36	0.73
303	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(1), GNAQ(1), GNAS(4), GNB1(1), LIMK1(3), MAP2K1(1), MAPK1(1), MAPK3(1), NOX1(1), PIK3C2G(1), PLCB1(3), PTK2(1), RAF1(1), ROCK2(2)	18579015	23	22	23	4	3	11	7	0	2	0	0.37	0.74
304	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), CD3G(1), CD8A(1), ITGAL(1), ITGB2(3), PTPRC(1)	7738848	10	10	10	1	2	3	3	0	2	0	0.37	0.74
305	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB11A(1), RAB1A(1), RAB6A(1)	3261024	3	3	3	0	0	0	1	0	2	0	0.37	0.75
306	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(3), G6PD(1), GCLC(1), GCLM(1), GGT1(1), GPX5(1), GSS(1), GSTA1(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTZ1(1), IDH1(1), TXNDC12(1)	14852058	16	16	16	2	4	4	6	0	2	0	0.38	0.75
307	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(1), CAMK1G(1), CAMK2A(1), CAMK2D(3), MEF2A(1), MEF2C(2), PPARA(1), PPP3CA(3), PPP3CB(2), SLC2A4(1)	14370408	16	16	16	7	2	3	7	0	4	0	0.38	0.75
308	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	57	AKT2(1), AKT3(2), BLNK(1), BTK(2), CARD11(2), CD19(1), CD22(1), CD79A(1), CR2(2), IFITM1(1), IKBKB(2), INPP5D(2), JUN(1), KRAS(1), LYN(3), MALT1(1), NFAT5(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKB2(4), PIK3CB(3), PIK3CG(2), PIK3R3(1), PLCG2(2), PPP3CA(3), PPP3CB(2), VAV1(1), VAV3(1)	48644115	51	45	51	18	6	19	12	3	8	3	0.38	0.75
309	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(1), CASP8(2), RIPK1(3), TNFRSF1A(1)	5788419	7	7	7	2	0	3	1	0	3	0	0.38	0.75
310	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	65	MRPL13(1), MRPS7(2), RPL13A(2), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL29(1), RPL35(2), RPL3L(1), RPL41(1), RPS10(1), RPS2(1), RPS21(1), RPS27(1), RPS5(2), RPS6(1)	15928419	21	20	21	6	5	5	6	4	1	0	0.38	0.75
311	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(1), NR0B2(2), NR1H4(1)	3914547	5	5	5	4	0	2	3	0	0	0	0.38	0.75
312	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(1), HLA-DRB1(2), IL2(1)	3054168	4	4	4	3	0	1	2	1	0	0	0.38	0.75
313	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	29	APC(3), AR(3), BRAF(2), CCL13(1), EGFR(4), GNAI1(1), GNAQ(1), ITPR1(7), ITPR3(4), KCNJ3(1), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(4), PITX2(1), PTX3(1), RAF1(1)	34235175	37	37	37	14	7	12	6	4	8	0	0.38	0.75
314	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	22	NRF1(1), UBE2A(1), UBE2D2(2), UBE2J1(3), UBE2J2(1), UBE3A(1)	7147179	9	9	9	1	0	3	3	0	3	0	0.38	0.75
315	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	88	ACTB(2), BAD(1), CABIN1(5), CD3E(1), CD3G(1), CD69(1), CNR1(1), CREBBP(2), CSNK2A1(1), EGR2(1), EGR3(3), EP300(3), FCER1A(2), GRLF1(4), GSK3A(1), IFNB1(1), IL2(1), IL6(2), ITK(3), KPNA5(1), MAPK14(1), MAPK8(2), MEF2A(1), NFAT5(1), NFATC3(3), NFATC4(3), NFKB2(4), NUP214(4), OPRD1(1), P2RX7(1), PAK1(2), PPP3CB(2), PTPRC(1), RELA(1), RPL13A(2), SP1(1), SP3(3), TRPV6(1), VAV1(1), VAV3(1), XPO5(1)	64826034	74	63	73	30	13	16	18	3	21	3	0.39	0.76
316	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	14	GNAS(4), GNB1(1), NFKB1(1), NOS3(2), NPPA(1), RELA(1)	8879598	10	10	10	1	1	3	3	1	2	0	0.39	0.76
317	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(2), EIF2B5(1), EIF2S1(1), EIF2S2(1), ELAVL1(2), FLT1(2), FLT4(1), KDR(2), NOS3(2), PLCG1(4), PTK2(1), PXN(1), SHC1(1)	20629830	21	20	21	11	4	6	5	3	3	0	0.39	0.76
318	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(1), CCND1(1), CDK2(1), E2F1(2), MDM2(1)	4914351	6	6	6	0	3	0	2	0	1	0	0.39	0.76
319	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(3), ARHGDIB(1), CASP1(1), CASP8(2), JUN(1), PRF1(2)	9689784	11	11	11	2	0	5	2	0	4	0	0.39	0.76
320	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(2), CS(1), HAO1(3), HAO2(1), MDH2(2), MTHFD1(4), MTHFD1L(1)	9980295	15	13	15	2	4	6	3	1	1	0	0.40	0.76
321	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(1), PDHB(1), SDHB(1)	18572424	24	23	24	10	2	11	9	2	0	0	0.40	0.76
322	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT2(2), ST8SIA1(1)	4510272	4	4	3	1	2	0	0	0	2	0	0.40	0.76
323	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	42	ABCA1(5), ABCA10(2), ABCA12(4), ABCA13(13), ABCA3(2), ABCA4(5), ABCA5(3), ABCA6(1), ABCA8(4), ABCA9(3), ABCB1(3), ABCB10(1), ABCB11(4), ABCB6(1), ABCB7(1), ABCB8(2), ABCC1(3), ABCC10(2), ABCC11(1), ABCC12(3), ABCC2(3), ABCC4(3), ABCC5(1), ABCC6(2), ABCC8(7), ABCC9(3), ABCD1(2), ABCD2(1), ABCD3(2), ABCG5(1), CFTR(6), TAP1(1)	83159154	95	83	95	28	25	29	23	6	12	0	0.40	0.77
324	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	1124019	1	1	1	0	0	0	0	0	1	0	0.40	0.77
325	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(1), PTK2B(3), SHC1(1), SOS1(3)	6313671	8	8	8	1	2	2	3	0	1	0	0.41	0.77
326	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP68(1), SRP72(1), SRPR(7)	5603871	9	7	9	3	1	2	2	2	2	0	0.41	0.77
327	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	60	ATM(9), CCNB1(2), CCND1(1), CCND3(5), CCNG2(2), CDK2(1), CDK7(1), CREB3(1), CREB3L1(2), CREB3L3(1), E2F1(2), E2F3(1), E2F4(2), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(1), MNAT1(1), MYC(1), NACA(3), ORC2L(1), ORC3L(1), POLE2(1), RBL1(1), RPA1(1), TFDP2(1), TNXB(3)	53803854	53	47	53	9	11	15	7	3	14	3	0.41	0.77
328	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ARPC1A(1), ARPC1B(1), ARPC2(2), PAK1(2), PDGFRA(3), WASL(1)	7255677	10	10	10	6	5	0	3	1	1	0	0.41	0.77
329	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(2), JAK3(1), MAPK1(1), MAPK3(1), STAT3(1), TYK2(3)	8584017	10	9	9	2	0	3	3	1	3	0	0.41	0.77
330	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(1), ACAT1(1), ECHS1(1), EHHADH(2), HADHB(1)	6045975	7	7	7	5	1	2	2	1	1	0	0.42	0.78
331	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(2), CBS(1), CTH(1)	3350763	4	4	4	0	0	2	0	0	2	0	0.42	0.78
332	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(3), GSN(1), ITGA1(3), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), MYLK(5), PTK2(1), PXN(1), RAF1(1), ROCK1(1), SHC1(1), TLN1(7)	25392081	29	26	29	8	1	12	8	3	5	0	0.42	0.79
333	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(2), EP300(3), ESR1(2), MAPK1(1), MAPK3(1)	10444200	9	9	8	2	2	2	0	1	4	0	0.43	0.79
334	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDFT1(1), FDPS(1), IDI1(2), NQO1(1), PMVK(1), SQLE(1), VKORC1(1)	7224750	8	8	8	7	2	4	1	0	1	0	0.43	0.79
335	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	54	APC(3), AXIN1(1), CCND1(1), CCND3(5), CSNK1E(1), DVL3(1), FBXW2(1), FZD1(1), FZD3(2), FZD6(2), FZD9(1), JUN(1), LDLR(1), MAPK10(1), MYC(1), PAFAH1B1(1), PLAU(2), PPP2R5C(1), PPP2R5E(1), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKCZ(1), PRKD1(1), RHOA(2), SFRP4(1), TCF7(3), WNT10B(1), WNT11(2), WNT2B(1), WNT5B(1), WNT6(1)	39619515	47	42	47	19	10	15	10	6	3	3	0.43	0.79
336	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(2), UXS1(2)	3016650	5	4	5	0	2	1	0	2	0	0	0.43	0.79
337	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), AMT(1), ATIC(3), MTHFD1(4), MTHFD1L(1), MTHFS(1), MTR(5)	13366041	16	15	16	7	3	4	2	2	5	0	0.43	0.79
338	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	22	AKT2(1), AKT3(2), BAD(1), GRB2(1), GSK3A(1), IRS1(1), JAK1(1), JAK3(1), MAP4K1(1), MAPK1(1), MAPK3(1), PDK1(1), RAF1(1), SHC1(1), SOS1(3), SOS2(1)	22329294	19	18	19	5	1	8	4	1	5	0	0.44	0.79
339	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	30	ARG1(2), ARG2(1), ASL(3), ASS1(1), CKMT2(1), CPS1(2), DAO(1), EPRS(2), GATM(3), GLUD2(1), GOT2(1), NOS1(3), NOS3(2), P4HA3(1), PARS2(1), RARS(1), RARS2(1)	24175788	27	26	27	6	5	11	8	1	2	0	0.44	0.79
340	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	32	DLD(1), DUSP10(1), GAB1(1), GCK(2), IL1R1(1), JUN(1), MAP2K5(1), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(3), MAP3K4(3), MAP3K5(1), MAP3K9(1), MAPK10(1), MAPK8(2), MYEF2(1), NFATC3(3), PAPPA(4), SHC1(1), TRAF6(1), ZAK(1)	32111352	37	33	37	6	8	12	7	0	10	0	0.44	0.79
341	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), JUN(1), MAPK14(1), THBS1(3)	5522244	6	5	6	3	0	3	0	1	2	0	0.44	0.79
342	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	23	ABAT(3), ALDH5A1(1), CAD(7), CPS1(2), EPRS(2), GAD1(2), GAD2(3), GCLC(1), GCLM(1), GLS(1), GMPS(1), GOT2(1), GPT2(2), GSS(1), PPAT(1), QARS(2)	23776272	31	28	31	3	4	11	11	2	3	0	0.44	0.79
343	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	20	ALDOA(3), ALDOB(2), GOT2(1), GPT2(2), MDH2(2), ME2(1), ME3(1), PGK1(2), TKT(1)	12363702	15	15	15	2	4	9	1	1	0	0	0.44	0.79
344	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), CD3G(1), CD4(1), ITGAL(1), ITGB2(3), PTPRC(1)	8179431	10	10	10	2	2	3	3	0	2	0	0.44	0.79
345	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	29	IFNB1(1), IKBKB(2), IL1A(1), IL1R1(1), IL1RAP(2), IL1RN(2), IL6(2), IRAK1(1), IRAK2(2), IRAK3(1), JUN(1), MAP2K3(1), MAPK14(1), MAPK8(2), NFKB1(1), RELA(1), TGFB3(1), TRAF6(1)	19246734	24	22	24	5	4	11	3	1	5	0	0.44	0.79
346	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	11	ABL1(2), E2F1(2), MDM2(1), MYC(1), POLR1A(1), POLR1B(2), POLR1C(2), POLR1D(1)	9940749	12	12	12	4	2	1	4	2	3	0	0.44	0.79
347	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CAPN2(2), EP300(3), HDAC1(2), HDAC2(2), PPP3CA(3), PPP3CB(2)	17211129	19	17	18	7	4	5	4	0	6	0	0.45	0.79
348	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH7(2), ADHFE1(1), AKR1C1(1), AKR1C2(2), AKR1C3(1), AKR1C4(1), ALDH3B1(2), ALDH3B2(2), CYP1B1(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(1), CYP2C9(2), CYP2F1(1), CYP2S1(3), CYP3A4(3), CYP3A7(4), EPHX1(1), GSTA1(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTZ1(1), UGT1A10(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B15(2), UGT2B28(1), UGT2B4(1)	41307825	49	46	49	19	10	14	13	4	8	0	0.45	0.79
349	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(3), ACE2(1), AGT(3), ANPEP(3), CTSA(1), CTSG(1), ENPEP(1), MAS1(2)	14904786	15	15	15	6	4	4	2	1	4	0	0.45	0.79
350	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH11(2), RDH12(1), RDH14(1)	3500328	4	4	4	2	0	1	2	0	1	0	0.45	0.79
351	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(2), DHRS7(1), ESCO1(3), MYST3(1), MYST4(5), PNPLA3(4)	12283089	16	14	16	3	5	2	2	2	2	3	0.45	0.79
352	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	21	ABL1(2), ATM(9), ATR(2), CCND1(1), CDK2(1), CDK6(1), E2F1(2), HDAC1(2), TGFB3(1)	19928649	21	20	21	4	2	8	2	2	7	0	0.45	0.79
353	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	85	AKT3(2), CAPN1(3), CAPN10(1), CAPN11(1), CAPN2(2), CAPN6(1), CAV1(1), GRB2(1), ILK(2), ITGA10(1), ITGA11(4), ITGA2(2), ITGA2B(2), ITGA4(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGAD(1), ITGAL(1), ITGAM(1), ITGAV(3), ITGAX(2), ITGB1(2), ITGB2(3), ITGB3(2), ITGB4(4), ITGB5(2), ITGB8(1), MAP2K1(1), MAP2K3(1), MAPK10(1), MAPK4(2), MAPK6(1), PAK1(2), PAK2(1), PAK3(1), PTK2(1), PXN(1), RAPGEF1(3), RHO(2), ROCK1(1), ROCK2(2), SDCCAG8(3), SHC1(1), SHC3(1), SORBS1(4), SOS1(3), TLN1(7), TNS1(4), VAV3(1), VCL(3)	95732754	103	83	103	34	21	25	26	9	22	0	0.45	0.79
354	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(1), CBS(1), CTH(1), DNMT3A(3), DNMT3B(1), MAT2B(1), MTR(5)	12459018	14	13	14	4	1	5	3	3	2	0	0.46	0.80
355	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), AP2A1(3), AP2M1(2), BIN1(1), DNM1(2), EPS15(1), PPP3CA(3), PPP3CB(2), SYNJ2(1)	15971007	17	17	17	6	0	7	4	1	5	0	0.46	0.80
356	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), EPOR(1), GRIN1(1), JAK2(2), NFKB1(1), RELA(1)	9009390	8	8	8	3	0	2	0	2	4	0	0.47	0.80
357	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), AMT(1), ATIC(3), MTHFD1(4), MTHFD1L(1), MTHFS(1), MTR(5)	13668213	16	15	16	7	3	4	2	2	5	0	0.47	0.80
358	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), GLB1(1), HEXB(1), LCT(3), ST3GAL1(1), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(1)	12058488	12	12	12	0	2	5	3	0	2	0	0.47	0.80
359	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	27	AKT2(1), AKT3(2), ANKRD6(4), APC(3), AXIN1(1), CER1(1), DKK4(1), GSK3A(1), LRP1(7), MVP(1), NKD1(1), PTPRA(1), SFRP1(2), WIF1(1)	27580800	27	26	27	10	8	6	5	3	5	0	0.47	0.81
360	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(1), CD3G(1), IL2(1), TGFB3(1), TGFBR1(2), TGFBR3(2), TOB1(1)	7884864	9	9	9	3	0	6	3	0	0	0	0.48	0.81
361	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	107	ATP12A(3), ATP4A(4), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(1), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), COX10(2), COX4I2(1), COX5A(1), COX6C(1), COX7B2(1), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA2(1), NDUFA3(1), NDUFB9(1), NDUFS2(1), NDUFS3(1), NDUFV1(1), NDUFV2(1), PPA1(1), SDHA(1), SDHB(1), TCIRG1(1), UQCRC1(2), UQCRC2(1)	39958698	44	42	44	8	6	10	11	9	8	0	0.48	0.81
362	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK1(1), JAK2(2), PTPRU(5), STAT1(1)	8494785	9	9	9	4	1	3	0	1	4	0	0.48	0.81
363	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), ACO2(2), IDH1(1), MDH2(2), SDHB(1), SUCLA2(1)	6645249	8	8	8	2	2	2	4	0	0	0	0.48	0.81
364	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(1), HDAC9(1), MEF2A(1), MEF2C(2)	5971446	6	6	6	2	1	1	1	0	3	0	0.48	0.82
365	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(1), BRAF(2), CREB3(1), MAPK1(1), RAF1(1), SNX13(1), TERF2IP(2)	8413665	9	9	9	1	1	2	5	0	1	0	0.49	0.82
366	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	37	ARNTL(1), AZIN1(1), CBX3(1), CRY1(1), EIF4G2(1), ETV6(1), HSPA8(3), IDI1(2), MYF6(1), NCKAP1(3), NR1D2(1), PER1(2), PER2(3), PPP2CB(2), TOB1(1), UCP3(1), VAPA(1), ZFR(4)	26284401	30	28	30	11	7	9	5	3	6	0	0.49	0.83
367	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(3), ESR1(2), GREB1(1), MTA3(1)	7239960	7	7	7	3	2	2	1	1	1	0	0.49	0.83
368	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	6	CDK2(1), CUL1(1), E2F1(2), FBXW7(1)	4651725	5	5	5	0	1	1	2	0	1	0	0.50	0.83
369	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	ARSB(3), GLB1(1), GUSB(1), HEXB(1), HGSNAT(1), HPSE(3), HPSE2(1), HYAL2(1), IDS(2), LCT(3), NAGLU(1)	14409954	18	17	18	3	3	7	6	0	2	0	0.50	0.84
370	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	FLT3(2), IGF1(1), IL1A(1), IL6(2), KITLG(2), TGFB3(1)	6119490	9	7	9	4	3	1	3	0	2	0	0.50	0.84
371	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	19	IKBKB(2), IL1A(1), IL1R1(1), IRAK1(1), NFKB1(1), RELA(1), RIPK1(3), TLR4(7), TNFAIP3(1), TNFRSF1A(1), TRAF6(1)	15370719	20	18	19	6	3	9	4	0	4	0	0.50	0.84
372	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(3), GLB1(1), GUSB(1), HEXB(1), IDS(2), LCT(3), NAGLU(1)	9843912	12	12	12	1	2	5	4	0	1	0	0.51	0.84
373	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	58	AKT2(1), AKT3(2), BAD(1), CDK2(1), CREB3(1), EBP(1), ERBB4(4), F2RL2(1), GAB1(1), GRB2(1), GSK3A(1), IGF1(1), INPPL1(1), IRS1(1), IRS4(1), MET(4), MYC(1), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PARD3(3), PDK1(1), PREX1(5), PTK2(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SLC2A4(1), SOS1(3), SOS2(1), TSC1(2), TSC2(2), YWHAB(1)	50891646	55	46	55	13	10	21	10	4	7	3	0.51	0.84
374	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(2), HDAC3(1), NCOA1(1), NCOA2(1), NCOA3(4), NCOR2(3), POLR2A(2), RARA(1), TBP(1)	17054973	16	16	16	7	2	4	5	1	4	0	0.51	0.84
375	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	106	ADA(2), ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADK(1), ADSL(1), AK2(1), AK5(1), AMPD1(3), ATIC(3), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(1), ENPP1(3), ENPP3(2), ENTPD1(2), FHIT(1), GMPS(1), GUCY1A2(2), GUCY2C(5), GUCY2D(1), GUCY2F(2), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(2), NT5E(3), PAICS(1), PAPSS1(2), PDE1A(2), PDE4A(1), PDE4B(2), PDE4C(3), PDE4D(3), PDE5A(1), PDE6B(2), PDE6C(2), PDE6G(1), PDE9A(3), PFAS(1), POLB(1), POLD2(1), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2A(2), POLR2B(3), POLR2H(1), PPAT(1), PRPS2(1), PRUNE(3), RRM2(1)	91146939	103	85	102	35	22	28	25	10	18	0	0.51	0.84
376	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(1), BHMT(1), CBS(1), CTH(1), DNMT3A(3), DNMT3B(1), MAT2B(1), MTAP(1), MTR(5)	14677650	16	15	16	4	1	7	3	3	2	0	0.52	0.84
377	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(2), JAK1(1), JAK2(2), TYK2(3)	7770282	9	8	8	2	1	0	4	2	2	0	0.52	0.84
378	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(2), JAK1(1), JAK2(2), TYK2(3)	7770282	9	8	8	2	1	0	4	2	2	0	0.52	0.84
379	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ALDH1B1(1), ALDH3B1(2), ALDH3B2(2), ALDH9A1(1), AMDHD1(1), AOC2(1), AOC3(2), ASPA(1), CARM1(1), CNDP1(2), DDC(1), HAL(2), LCMT1(1), LCMT2(3), MAOA(2), METTL2B(2), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1), PRPS2(1)	28319499	34	29	34	10	6	8	10	4	6	0	0.52	0.84
380	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C2(1), C3(2), C5(3), C6(4), C7(3), C9(1), MASP1(1), MASP2(1), MBL2(1)	15790008	17	17	17	4	2	6	4	2	3	0	0.52	0.84
381	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(3), ALDOB(2), GOT2(1), GPT2(2), MDH2(2), ME3(1), PGK1(2), TKT(1), TKTL1(1), TKTL2(1)	13850733	16	16	16	4	4	10	1	1	0	0	0.52	0.84
382	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C2(1), C3(2), C5(3), C6(4), C7(3), C9(1)	13106457	14	14	14	4	2	5	3	2	2	0	0.53	0.84
383	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), JUN(1), MAPK3(1), OPRK1(2), POLR2A(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	9177714	10	10	10	3	3	2	2	2	1	0	0.53	0.84
384	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	FDFT1(1), FDPS(1), HMGCS1(1), IDI1(2), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1)	8798478	9	9	9	8	2	3	2	0	2	0	0.53	0.84
385	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACA(1), ACACB(8), MCAT(1)	8967816	10	10	10	1	5	5	0	0	0	0	0.53	0.84
386	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	10	MAP2K1(1), MAP2K3(1), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(1), RELA(1), SP1(1)	7287111	8	8	8	2	0	6	1	0	1	0	0.53	0.84
387	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	44	AKT2(1), AKT3(2), CAP1(2), F2RL2(1), GRB2(1), GSK3A(1), INPPL1(1), IRS1(1), IRS4(1), MAPK1(1), MAPK3(1), PARD3(3), PDK1(1), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SLC2A4(1), SORBS1(4), SOS1(3), SOS2(1), YWHAB(1)	38476737	34	33	34	13	6	11	9	2	6	0	0.53	0.84
388	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	49	AKR1C3(1), ALOX12(1), CBR3(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(1), CYP2C9(2), CYP4F2(1), DHRS4(1), GGT1(1), GPX5(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(6), PLA2G6(2), PTGDS(1), PTGS2(1), TBXAS1(1)	27431742	31	30	29	5	6	10	8	3	4	0	0.53	0.84
389	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), DRD2(1), GRM1(2), PLCB1(3), PPP3CA(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	11477466	13	13	13	6	7	2	3	1	0	0	0.53	0.84
390	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	EGF(2), EGFR(4), GRB2(1), MAP2K1(1), MAPK1(1), MAPK3(1), PTPRB(2), RAF1(1), RASA1(2), SHC1(1), SOS1(3)	18580536	19	19	19	7	2	6	4	4	3	0	0.54	0.84
391	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	1294371	1	1	1	1	1	0	0	0	0	0	0.54	0.84
392	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(2), CTBS(1), CYB5R1(2), GFPT2(3), GNE(3), GNPNAT1(1), HEXB(1), HK1(1), HK3(2), MTMR6(1), NAGK(1), NANS(1), PGM3(1), RENBP(1)	20888907	22	21	22	2	4	5	8	2	3	0	0.54	0.84
393	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(1), AOC3(2), CES1(1), ESD(1)	4679610	5	5	5	2	0	3	1	0	1	0	0.54	0.84
394	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(5), CETP(1), LCAT(1), LDLR(1), LPL(1), LRP1(7), SCARB1(2), SOAT1(1)	18633264	19	19	19	8	10	3	3	0	3	0	0.54	0.84
395	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	132	APC(3), AXIN1(1), CAMK2A(1), CAMK2D(3), CCND1(1), CCND3(5), CER1(1), CHD8(2), CREBBP(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(1), CSNK2A2(1), CUL1(1), DAAM1(1), DAAM2(1), DKK4(1), DVL3(1), EP300(3), FZD1(1), FZD3(2), FZD6(2), FZD9(1), JUN(1), LRP6(2), MAPK10(1), MAPK8(2), MYC(1), NFAT5(1), NFATC3(3), NFATC4(3), NKD1(1), NLK(1), PLCB1(3), PLCB2(2), PLCB3(1), PLCB4(6), PPP2CB(2), PPP3CA(3), PPP3CB(2), PRICKLE1(2), PRICKLE2(2), PRKACA(1), PRKCG(1), RHOA(2), ROCK1(1), ROCK2(2), SFRP1(2), SFRP4(1), SIAH1(2), SMAD2(3), SMAD3(2), SMAD4(1), TBL1X(3), TCF7(3), TCF7L2(1), VANGL2(1), WIF1(1), WNT10B(1), WNT11(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT6(1), WNT8B(1), WNT9A(1)	109551039	113	92	112	37	25	32	27	9	17	3	0.54	0.85
396	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1B1(1), ALDH9A1(1), CYP2C19(1), CYP2C9(2), DHRS2(2), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(3), MYST3(1), MYST4(5), PNPLA3(4)	22605609	26	24	26	9	6	5	7	3	2	3	0.55	0.85
397	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	12	NDUFA1(1), NDUFA10(1), NDUFS2(1), NDUFV1(1), NDUFV2(1)	4791657	5	5	5	1	0	2	2	0	1	0	0.55	0.85
398	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGAP3(1), ARFGEF2(2), COPA(1), GBF1(4), GPLD1(2), KDELR3(1)	11684322	13	13	13	0	3	2	3	3	2	0	0.55	0.85
399	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	138	ADA(2), ADCY1(3), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY8(2), ADCY9(5), ADK(1), ADSL(1), AK2(1), AK5(1), AK7(1), AMPD1(3), ATIC(3), ENPP1(3), ENPP3(2), ENTPD1(2), ENTPD4(1), ENTPD6(1), FHIT(1), GMPR2(1), GMPS(1), GUCY1A2(2), GUCY2C(5), GUCY2D(1), GUCY2F(2), IMPDH1(2), IMPDH2(1), NME6(1), NME7(2), NPR1(1), NPR2(2), NT5C1B(3), NT5C3(1), NT5E(3), PAICS(1), PAPSS1(2), PDE10A(1), PDE11A(1), PDE1A(2), PDE2A(3), PDE3B(1), PDE4A(1), PDE4B(2), PDE4C(3), PDE4D(3), PDE5A(1), PDE6G(1), PDE9A(3), PFAS(1), POLA1(4), POLD2(1), POLD4(1), POLE2(1), POLE3(1), POLR1A(1), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(2), POLR2B(3), POLR2H(1), POLR3A(1), POLR3B(2), POLR3GL(2), PPAT(1), PRPS2(1), PRUNE(3), RRM2(1), XDH(3)	118570569	128	102	127	46	27	35	38	9	19	0	0.55	0.85
400	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(2), DFFB(2), HMGB2(1), PRF1(2), SET(1)	7647588	9	8	9	3	2	2	0	2	3	0	0.55	0.85
401	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	9	JUN(1), KEAP1(2), MAPK1(1), MAPK14(1), MAPK8(2)	6141291	7	6	7	1	0	3	0	0	2	2	0.56	0.86
402	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), CASP8(2), DFFB(2), PRF1(2), SCAP(3), SREBF2(3)	12415416	13	13	13	2	2	5	1	2	3	0	0.56	0.86
403	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(2), CAPN1(3), CDK5(1), MAPT(1)	6567678	7	7	7	1	0	4	1	1	1	0	0.56	0.86
404	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH7(2), ADHFE1(1)	4275531	4	4	4	1	0	3	1	0	0	0	0.57	0.86
405	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	62	ACYP1(1), ADH1A(1), ADH7(2), ADHFE1(1), ALDH1B1(1), ALDH3B1(2), ALDH3B2(2), ALDH9A1(1), ALDOA(3), ALDOB(2), DLD(1), ENO1(1), ENO3(1), G6PC2(1), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(3), PFKP(2), PGK1(2), PGM1(1), PGM3(1)	40754688	40	37	40	11	6	19	5	7	3	0	0.57	0.87
406	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25B(3), GRB2(1), PTPRA(1)	6812559	7	7	7	2	0	4	0	2	1	0	0.57	0.87
407	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), IFNB1(1), JAK1(1), STAT1(1), STAT2(1), TYK2(3)	8103381	8	8	7	3	2	0	3	2	1	0	0.57	0.87
408	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(1), NFKB1(1), NOX1(1), RELA(1), SOD1(1), XDH(3)	7579143	8	8	8	0	2	1	4	0	1	0	0.58	0.87
409	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	30	BAD(1), CRKL(1), E2F1(2), GRB2(1), IL2RG(1), IRS1(1), JAK1(1), JAK3(1), MAPK1(1), MAPK3(1), MYC(1), RAF1(1), SHC1(1), SOS1(3), STAT5B(4)	22824633	21	21	21	8	2	8	5	2	4	0	0.58	0.87
410	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(2), JAK3(1), PTPRU(5), SOAT1(1)	10227711	10	10	10	5	2	3	0	1	4	0	0.58	0.87
411	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), EHHADH(2)	3434418	3	3	3	4	0	0	2	1	0	0	0.58	0.87
412	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), AOX1(3), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(1), CYP2C9(2), CYP2D6(2), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(2), CYP4F8(2), DDC(1), ECHS1(1), EHHADH(2), GCDH(1), KYNU(1), MAOA(2), WARS2(1)	41060916	49	43	49	19	5	18	13	5	8	0	0.59	0.87
413	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), HLA-DRB1(2), IL12A(1), IL12B(1), IL12RB1(2), IL18R1(1), IL2(1)	9572667	9	9	9	6	1	0	3	3	2	0	0.59	0.87
414	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(1), CPT1A(2), LEPR(3), PRKAA2(2), PRKAB1(1), PRKAG2(1)	10819887	10	10	10	5	4	3	1	0	2	0	0.59	0.87
415	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGF(2), EGFR(4), TF(1), TFRC(1)	9514362	9	9	9	4	1	2	2	4	0	0	0.59	0.87
416	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	39	EGF(2), EGFR(4), ETS1(2), ETS2(3), HOXA7(1), IKBKB(2), JUN(1), MAP2K1(1), MAP2K3(1), MAP3K5(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(1), PRKCG(1), PRKCH(1), PRKCQ(2), RAF1(1), RELA(1), RIPK1(3), SP1(1), TNFRSF1A(1)	32729385	35	34	35	14	5	14	7	5	4	0	0.59	0.88
417	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SNAP23(2), SNAP25(1), STX10(1), STX17(1), STX3(1), STX6(1), STX7(1), TSNARE1(3), USE1(1)	12155832	12	12	12	9	3	2	1	3	3	0	0.59	0.88
418	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	IL10RA(1), IL10RB(3), IL1A(1), IL6(2), JAK1(1), STAT1(1), STAT3(1)	9056034	10	9	10	1	3	2	1	1	3	0	0.60	0.89
419	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(1), ANXA4(1), ANXA6(1), CYP11A1(1), EDN1(2), EDNRB(1), PLA2G4A(6), PTGDR(1), PTGDS(1), PTGFR(1), PTGS2(1), S100A6(1), TBXAS1(1)	15335229	19	18	18	3	6	5	6	2	0	0	0.61	0.89
420	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	21	CASP2(2), IKBKB(2), JUN(1), MAP2K3(1), MAPK14(1), MAPK8(2), NFKB1(1), RELA(1), RIPK1(3), TANK(1), TNFRSF1A(1)	14410968	16	15	16	3	0	10	1	1	4	0	0.61	0.89
421	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), ARSB(3), ARSE(1), CYP11B1(2), CYP11B2(3), HSD17B2(1), HSD3B2(2), SRD5A1(1), SRD5A2(2), SULT1E1(2), UGT1A10(1), UGT1A6(2), UGT2B15(2), UGT2B4(1)	19720779	24	21	24	6	6	7	6	3	2	0	0.61	0.89
422	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(2), UXS1(2)	3811119	5	4	5	0	2	1	0	2	0	0	0.61	0.90
423	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), HMGCS1(1), HMGCS2(1), OXCT1(1), OXCT2(1)	5172414	5	5	5	2	0	2	2	1	0	0	0.62	0.90
424	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), CA2(1), CA4(1), CA6(2), CA9(3), CPS1(2), CTH(1), GLS(1), HAL(2)	14028690	14	14	14	3	2	5	3	1	3	0	0.62	0.90
425	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), PCYT1A(1), PDHA1(1), PDHA2(1)	5048199	5	5	5	1	0	4	1	0	0	0	0.62	0.90
426	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(1), FARSB(3), GOT2(1), PAH(1)	6516471	7	7	7	0	1	3	2	1	0	0	0.62	0.90
427	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(1), ACADSB(1), ACADVL(2), ACAT1(1), ACOX1(2), ACOX3(1), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(2), ADH1A(1), ADH7(2), ADHFE1(1), ALDH1B1(1), ALDH9A1(1), CPT1A(2), CPT1C(2), CPT2(1), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HADHB(1), HSD17B10(1), HSD17B4(3), PECI(1)	35644128	36	35	36	13	6	15	6	5	4	0	0.62	0.90
428	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CREBBP(2), EP300(3), HDAC3(1), IKBKB(2), NFKB1(1), RELA(1), RIPK1(3), TNFRSF1A(1), TRAF6(1)	16086096	15	15	14	3	1	8	0	1	5	0	0.63	0.90
429	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA3(1), P2RY1(1), P2RY2(1)	4245111	4	4	4	2	1	3	0	0	0	0	0.63	0.90
430	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GCK(2), GNE(3), HEXB(1), HK1(1), HK3(2), PGM3(1), RENBP(1)	12357618	11	11	11	2	2	4	3	0	2	0	0.63	0.90
431	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	9	GHR(2), IGF1(1), IGF1R(1), SHC1(1), SOD1(1)	6079437	6	6	6	2	1	1	4	0	0	0	0.64	0.90
432	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	42	AKT2(1), AKT3(2), BAD(1), BCR(1), BLNK(1), BTK(2), CD19(1), CD22(1), CR2(2), GRB2(1), GSK3A(1), INPP5D(2), ITPR1(7), ITPR3(4), LYN(3), MAP4K1(1), MAPK1(1), MAPK3(1), NR0B2(2), PDK1(1), PLCG2(2), PPP3CA(3), PPP3CB(2), PTPRC(1), RAF1(1), SHC1(1), SOS1(3), SOS2(1), VAV1(1)	49916178	51	47	51	14	7	22	14	2	6	0	0.64	0.90
433	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), ARSE(1), CARM1(1), CYP11B1(2), CYP11B2(3), HSD17B1(1), HSD17B2(1), HSD3B2(2), LCMT1(1), LCMT2(3), METTL2B(2), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1), SRD5A1(1), SRD5A2(2), SULT1E1(2), UGT1A10(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B15(2), UGT2B28(1), UGT2B4(1)	35708010	41	36	41	14	9	10	14	3	5	0	0.64	0.90
434	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(1), ARHGDIB(1), CASP1(1), CASP2(2), CASP6(1), CASP8(2), DFFB(2), LMNB1(1), PRF1(2)	13661115	13	13	13	2	1	5	2	2	3	0	0.64	0.90
435	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	40	AGMAT(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(2), ARG1(2), ARG2(1), ASL(3), CKMT2(1), CPS1(2), DAO(1), GATM(3), GOT2(1), MAOA(2), NOS1(3), NOS3(2), P4HA3(1), RARS(1)	30495543	33	30	33	10	5	17	7	1	3	0	0.64	0.90
436	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(2)	2765178	2	2	2	0	0	0	1	0	1	0	0.64	0.90
437	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	18	BAD(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(1), RAF1(1), RELA(1), RHOA(2)	10211487	10	10	10	4	2	4	3	0	1	0	0.64	0.90
438	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(1), CD3G(1), CD4(1), HLA-DRB1(2), PTPRC(1), ZAP70(1)	6755775	7	7	7	5	2	2	2	1	0	0	0.64	0.91
439	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	35	ELK1(2), GRB2(1), MAP3K5(1), MAP3K9(1), MAPK14(1), MAX(1), MEF2A(1), MEF2C(2), MYC(1), PLA2G4A(6), RIPK1(3), SHC1(1), STAT1(1), TGFB3(1), TGFBR1(2)	24270597	25	23	24	7	4	9	5	2	5	0	0.65	0.91
440	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(1), GPR109B(1), GPR161(2), GPR34(1), GPR75(1)	7405749	7	7	7	7	0	2	2	3	0	0	0.65	0.91
441	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(1), CTH(1), GGT1(1), MAT2B(1), PAPSS1(2), SEPHS1(1)	8761974	8	8	8	4	0	6	1	0	1	0	0.65	0.91
442	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH3B1(2), ALDH3B2(2), ALDH9A1(1), AOC2(1), AOC3(2), ASPA(1), CNDP1(2), DDC(1), HAL(2), MAOA(2), PRPS2(1)	18196230	21	19	21	7	4	7	3	4	3	0	0.65	0.91
443	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(4), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(4), COL4A6(3), F12(1), F2(2), F2R(2), F5(7), F8(1), FGA(3), KLKB1(1), PROC(1), SERPINC1(2)	33025473	35	34	35	11	6	11	8	6	4	0	0.65	0.91
444	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(1), GRIA2(1)	2589249	2	2	2	1	1	1	0	0	0	0	0.66	0.91
445	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC1A(1), ARPC1B(1), ARPC2(2), NCKAP1(3), NTRK1(1), PIR(1), WASF1(1), WASF3(1), WASL(1)	11461749	12	12	12	5	6	1	4	0	1	0	0.66	0.91
446	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	52	ADH1A(1), ADH7(2), ADHFE1(1), AGK(2), AGPAT3(2), AGPAT6(1), AKR1B1(2), ALDH1B1(1), ALDH9A1(1), CEL(1), DAK(2), DGKA(3), DGKD(1), DGKE(1), DGKG(4), DGKH(1), DGKI(5), GK2(1), GLA(2), GLB1(1), LCT(3), LPL(1), PNLIP(1), PNLIPRP1(2), PNPLA3(4), PPAP2A(1)	41479191	47	41	46	13	9	16	8	4	7	3	0.66	0.91
447	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	53	CAD(7), CTPS2(2), DPYD(1), DPYS(1), ENTPD1(2), NT5E(3), POLB(1), POLD2(1), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2A(2), POLR2B(3), POLR2H(1), RRM2(1), TK2(1), UCK2(2), UMPS(1), UPB1(3), UPP1(2)	40676103	42	38	42	12	7	10	10	4	11	0	0.66	0.91
448	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(1), PLCB1(3), RELA(1)	6134700	6	6	6	1	2	3	0	0	1	0	0.66	0.91
449	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	23	ARHGDIB(1), CASP6(1), CASP8(2), DFFB(2), JUN(1), LMNB1(1), MAPK8(2), PAK1(2), PAK2(1), PRKDC(7), PTPN13(4), SPTAN1(2)	27052506	26	26	26	3	6	7	5	3	5	0	0.66	0.91
450	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ACAA2(1), ADH1A(1), ADH7(2), ADHFE1(1), AKR1C4(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(1), SRD5A1(1), SRD5A2(2)	17098068	19	17	19	5	1	12	3	1	2	0	0.67	0.91
451	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH1A(1), ADH7(2), ADHFE1(1), DHRS2(2), DHRS7(1), ESCO1(3), MYST3(1), MYST4(5), PNPLA3(4)	18603351	20	18	20	4	5	5	3	2	2	3	0.67	0.91
452	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(3), CDK7(1), NEK1(1)	5474079	5	5	5	2	1	2	0	2	0	0	0.67	0.91
453	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C2(1), C3(2), C5(3), C6(4), C7(3), C9(1), MASP1(1)	15607488	15	15	15	4	2	5	3	2	3	0	0.67	0.91
454	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT3(1), CHPF(1), CHST11(1), CHST3(1), DSE(4), UST(1), XYLT2(1)	9839856	10	10	10	7	3	4	2	0	1	0	0.67	0.91
455	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	10	CDK2(1), CUL1(1), E2F1(2)	4685187	4	4	4	0	1	1	1	0	1	0	0.67	0.91
456	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IL12A(1), IL12B(1), IL15(1), IL1A(1), IL2(1), IL6(2)	7624773	8	7	8	4	3	0	1	1	3	0	0.68	0.91
457	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAA2(1), ADH1A(1), ADH7(2), ADHFE1(1), AKR1C4(1), ALDH1B1(1), ALDH9A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(1), RDH11(2), RDH12(1), RDH14(1), SLC27A5(2), SOAT1(1), SRD5A1(1), SRD5A2(2)	23033517	23	22	23	6	2	11	5	1	4	0	0.68	0.91
458	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	33	BRAF(2), CREB3(1), CREBBP(2), CRKL(1), EGR1(1), EGR2(1), EGR3(3), ELK1(2), GNAQ(1), JUN(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), NTRK1(1), OPN1LW(1), PIK3C2G(1), RPS6KA3(2), SHC1(1), TERF2IP(2)	29928210	29	28	29	6	5	7	7	2	8	0	0.68	0.91
459	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), CA2(1), CA4(1), CA6(2), CA9(3), CPS1(2), CTH(1), GLS(1), GLUD2(1), HAL(2)	15598362	15	15	15	4	2	5	4	1	3	0	0.68	0.91
460	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREBBP(2), EP300(3), NCOA3(4), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RARA(1)	14774487	14	12	13	5	4	1	0	3	6	0	0.69	0.92
461	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	7	CDK2(1), CUL1(1), E2F1(2)	4798755	4	4	4	0	1	1	1	0	1	0	0.69	0.92
462	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), NFKB1(1), PLCB1(3), RAF1(1), RELA(1)	11420682	11	11	11	3	2	6	1	0	2	0	0.69	0.92
463	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CRY1(1), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(2), PER2(3), PER3(2)	11869884	12	12	12	7	4	4	1	0	3	0	0.69	0.92
464	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	17	CAMK2A(1), CAMK2D(3), ITPR1(7), ITPR3(4), NFAT5(1), PDE6A(1), PDE6B(2), PDE6C(2), PDE6G(1), SLC6A13(1), TF(1)	24516999	24	24	24	11	6	5	6	1	6	0	0.70	0.93
465	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), HLCS(1)	2248545	2	2	2	0	1	0	1	0	0	0	0.70	0.93
466	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	18	EIF4A2(3), EIF4G2(1), EIF4G3(2), GHR(2), IRS1(1), MAPK1(1), MAPK14(1), MAPK3(1), PABPC1(3), PDK2(1)	16797417	16	15	16	7	1	7	2	2	4	0	0.70	0.93
467	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), ASCC3(1), ATP13A2(1), DDX41(1), DDX50(3), DDX55(3), DDX56(1), DHX58(2), ENTPD7(1), ERCC3(2), GCH1(1), IFIH1(1), NUDT8(1), RAD54B(4), RAD54L(2), SETX(6), SKIV2L2(1), SMARCA2(3), SMARCA5(1)	45087510	43	38	42	6	9	9	12	6	7	0	0.70	0.93
468	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR24(1), EBP(1), FDFT1(1), FDPS(1), IDI1(2), NQO1(1), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1), VKORC1(1)	13375167	12	12	12	10	3	5	2	0	2	0	0.71	0.93
469	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	56	B3GALNT1(1), B3GALT1(1), B3GALT4(2), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(1), B4GALT6(1), FUT2(2), FUT3(2), PIGA(1), PIGB(1), PIGG(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(1), ST6GALNAC4(1), ST8SIA1(1)	32978829	28	28	27	5	9	7	4	4	4	0	0.71	0.93
470	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(2), GLS(1)	3483090	3	3	3	1	0	1	0	1	1	0	0.72	0.95
471	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(1)	1909869	1	1	1	0	0	1	0	0	0	0	0.72	0.95
472	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	35	EEF1D(1), EEF2(1), EEF2K(2), EIF1AX(2), EIF2AK1(1), EIF2AK3(1), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF4A2(3), EIF4G3(2), EIF5(1), EIF5B(2), ETF1(1), GSPT2(2), PABPC1(3), PABPC3(1), SLC35A4(2)	30443322	28	27	28	12	4	5	7	5	7	0	0.73	0.95
473	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	DNAJC3(2), EIF2S1(1), EIF2S2(1), NFKB1(1), RELA(1)	6566157	6	6	6	0	1	2	2	0	1	0	0.73	0.95
474	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC1A(1), ARPC1B(1), ARPC2(2), WASF1(1), WASL(1)	6118476	6	6	6	5	3	0	2	0	1	0	0.73	0.95
475	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN2(4), ACTN3(1), CTNNA1(1), CTNNA2(2), PTK2(1), PXN(1), VCL(3)	14072292	13	13	13	10	4	4	2	0	3	0	0.73	0.95
476	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	23	ADRBK1(1), AKT2(1), AKT3(2), GNAQ(1), ITPR1(7), ITPR3(4), NFKB1(1), NFKB2(4), PDK1(1), PHKA2(4), PIK3CB(3), PITX2(1), PLD1(1), PLD3(1)	30264351	32	27	32	11	6	10	4	2	7	3	0.73	0.95
477	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	42	ADH1A(1), ADH7(2), ADHFE1(1), AGPAT3(2), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), CEL(1), DGKA(3), DGKD(1), DGKE(1), DGKG(4), DGKH(1), GLA(2), GLB1(1), LCT(3), LPL(1), PNLIP(1), PNLIPRP1(2), PPAP2A(1)	33672405	35	33	34	12	4	17	6	3	5	0	0.74	0.95
478	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(1), AOC3(2), CES1(1), CES7(1), ESCO1(3), MYST3(1), MYST4(5), PLA1A(2), PNPLA3(4)	19069284	21	19	21	8	6	6	2	1	3	3	0.74	0.95
479	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT2(1), AKT3(2), BCR(1), BTK(2), CD19(1), GAB1(1), ITPR1(7), ITPR3(4), LYN(3), NR0B2(2), PDK1(1), PITX2(1), PLCG2(2), PREX1(5), PTPRC(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), TEC(1), VAV1(1)	38134005	41	35	41	9	7	16	8	3	7	0	0.74	0.95
480	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2)	8614437	8	8	8	7	0	5	2	1	0	0	0.74	0.95
481	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(3), ABCB11(4), ABCC1(3)	11039418	10	10	10	9	1	3	4	1	1	0	0.74	0.95
482	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	33	ARSE(1), B4GALT6(1), CERK(1), DEGS1(2), ENPP7(1), GLA(2), GLB1(1), LCT(3), NEU2(1), PPAP2A(1), SGMS1(1), SGPP1(1), SGPP2(1), SMPD2(2), SPHK2(2), SPTLC1(1), SPTLC2(2), UGT8(1)	23712897	25	24	25	7	4	8	8	1	4	0	0.74	0.95
483	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS2(2), CARS2(1), DARS(1), DARS2(1), EARS2(3), EPRS(2), FARS2(1), FARSA(1), FARSB(3), GARS(1), IARS(5), IARS2(2), LARS2(2), NARS(1), NARS2(1), PARS2(1), QARS(2), RARS(1), RARS2(1), SARS(2), SARS2(2), TARS(4), TARS2(2), WARS2(1)	40526031	43	39	43	9	7	14	14	3	5	0	0.75	0.95
484	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	ARSB(3), GLB1(1), GUSB(1), HEXB(1), HGSNAT(1), HPSE(3), HPSE2(1), HYAL2(1), IDS(2), LCT(3), MAN2B1(2), MAN2B2(3), MANBA(1), NAGLU(1), NEU2(1)	24132186	25	24	25	7	3	7	11	1	3	0	0.75	0.95
485	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	51	ALG2(1), BAK1(1), BFAR(1), BTK(2), CAD(7), CASP8(2), EGFR(4), EPHB2(1), IL1A(1), MAP3K5(1), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1), MET(4), NFAT5(1), NFKB1(1), NFKB2(4), NR0B2(2), PTPN13(4), RIPK1(3), ROCK1(1), TUFM(2)	47929245	48	44	48	11	9	16	4	5	8	6	0.75	0.95
486	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CRY1(1), CSNK1E(1), PER1(2)	5832021	5	5	5	4	1	3	0	0	1	0	0.76	0.96
487	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	CREBBP(2), EP300(3), IL2RG(1), JAK1(1), JAK3(1), PTK2B(3), STAT5B(4)	17579211	15	14	14	5	3	3	1	3	5	0	0.76	0.96
488	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	55	ATP12A(3), ATP6V0A4(2), ATP6V0B(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), ATP7B(1), COX10(2), COX5A(1), COX6C(1), NDUFA1(1), NDUFA10(1), NDUFS2(1), NDUFV1(1), NDUFV2(1), SDHA(1), SDHB(1), UQCRC1(2)	25584234	24	23	24	8	5	6	5	2	6	0	0.76	0.96
489	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(3), MMP9(1)	5542524	4	4	3	4	1	3	0	0	0	0	0.76	0.96
490	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	88	CD2BP2(1), CLK4(1), COL2A1(3), CPSF1(2), CPSF3(1), CPSF4(2), CSTF2T(1), CSTF3(3), DDX20(2), DHX15(1), DHX16(1), DHX38(2), DHX8(1), DICER1(1), FUS(1), GIPC1(1), NCBP1(1), NUDT21(1), NXF1(2), PABPN1(1), PAPOLA(1), POLR2A(2), PRPF4(2), PRPF4B(3), PRPF8(5), PSKH1(2), PTBP1(2), RBM17(1), RBM5(1), SF3B2(1), SF3B4(1), SF4(4), SFRS16(3), SFRS2(1), SFRS4(2), SFRS5(1), SFRS9(1), SNRPB(1), SPOP(1), SRPK1(1), SRRM1(1), SUPT5H(4), TXNL4A(1), XRN2(3)	74995440	74	65	74	17	15	22	19	4	12	2	0.77	0.96
491	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(1), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(2), POLR2B(3), POLR2H(1), POLR3A(1), POLR3B(2), POLR3GL(2)	17322162	17	16	17	8	3	3	6	1	4	0	0.77	0.96
492	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(4), COL4A6(3), SLC23A1(2), SLC2A3(2)	18875103	19	18	19	9	3	6	7	1	2	0	0.77	0.96
493	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO3(1), FARS2(1), GOT2(1), PAH(1)	6207201	5	5	5	0	0	2	1	2	0	0	0.77	0.96
494	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	25	CABIN1(5), CAMK1(1), CAMK1G(1), IGF1(1), IGF1R(1), INSR(2), MAPK14(1), MEF2A(1), MEF2C(2), PPP3CA(3), PPP3CB(2)	20389512	20	18	20	9	3	6	6	1	4	0	0.78	0.97
495	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(2), POLR2A(2), POLR2B(3), POLR2H(1)	8445606	8	7	8	5	3	0	2	0	3	0	0.78	0.97
496	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(1), ACO2(2), IDH1(1), MDH2(2), SUCLA2(1)	9951396	9	9	9	2	2	4	3	0	0	0	0.78	0.97
497	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), OXCT1(1)	2475174	2	2	2	1	0	1	1	0	0	0	0.78	0.97
498	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	12	EGFR(4), IGF1R(1), MYC(1), POLR2A(2), TEP1(7)	17720157	15	15	15	4	1	6	2	5	1	0	0.79	0.97
499	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	30	CREB3(1), DUSP10(1), EEF2K(2), ELK1(2), IL1R1(1), MAP2K3(1), MAP3K10(4), MAP3K4(3), MAP3K5(1), MAPK1(1), MAPK14(1), MYEF2(1), NFKB1(1), SRF(1), TRAF6(1)	22233978	22	21	22	7	3	9	8	0	2	0	0.79	0.97
500	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(2), ACTB(2), ACTG1(1), ARHGEF2(1), CD14(1), CTTN(1), EZR(2), HCLS1(1), ITGB1(2), KRT18(1), NCL(1), RHOA(2), ROCK1(1), ROCK2(2), TLR4(7), TLR5(1), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2B(1), TUBB2C(2), TUBB4(1), WAS(1), WASL(1)	38262783	39	35	38	13	6	9	10	3	11	0	0.79	0.97
501	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(2), ACTB(2), ACTG1(1), ARHGEF2(1), CD14(1), CTTN(1), EZR(2), HCLS1(1), ITGB1(2), KRT18(1), NCL(1), RHOA(2), ROCK1(1), ROCK2(2), TLR4(7), TLR5(1), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2B(1), TUBB2C(2), TUBB4(1), WAS(1), WASL(1)	38262783	39	35	38	13	6	9	10	3	11	0	0.79	0.97
502	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	59	APAF1(1), BAD(1), BAK1(1), BCL2L11(1), CASP1(1), CASP2(2), CASP6(1), CASP8(2), DFFB(2), FAS(1), FASLG(1), IKBKB(2), IRF3(1), IRF6(2), JUN(1), MAPK10(1), MDM2(1), MYC(1), NFKB1(1), PLEKHG5(3), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TNFRSF21(2)	36769161	36	34	36	9	7	15	5	2	7	0	0.80	0.97
503	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(1), ATF3(1), CYR61(1), IFRD1(1), IL1A(1), IL1R1(1)	7695246	6	6	6	2	1	1	3	1	0	0	0.80	0.97
504	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	40	AKT2(1), AKT3(2), ARHGEF11(1), BTK(2), GDI1(3), INPPL1(1), ITPR1(7), ITPR3(4), LIMK1(3), MYLK(5), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PDK1(1), PIK3CG(2), PITX2(1), RHO(2), ROCK1(1), ROCK2(2), RPS4X(1), WASF1(1), WASL(1)	47939892	46	40	46	20	9	11	10	5	11	0	0.80	0.97
505	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1)	5692089	5	5	5	3	0	5	0	0	0	0	0.80	0.97
506	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1)	5692089	5	5	5	3	0	5	0	0	0	0	0.80	0.97
507	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	83	CAD(7), CTPS2(2), DPYD(1), DPYS(1), ENTPD1(2), ENTPD4(1), ENTPD6(1), NME6(1), NME7(2), NT5C1B(3), NT5C3(1), NT5E(3), POLA1(4), POLD2(1), POLD4(1), POLE2(1), POLE3(1), POLR1A(1), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(2), POLR2B(3), POLR2H(1), POLR3A(1), POLR3B(2), POLR3GL(2), RRM2(1), TK2(1), UCK2(2), UMPS(1), UPB1(3), UPP1(2), UPRT(1)	59012265	61	53	61	19	11	14	19	5	12	0	0.80	0.97
508	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	27	ATG7(2), IFNA10(1), IFNA14(1), IFNA2(2), IFNA4(1), PIK3C3(2), PIK3R4(3), PRKAA2(2)	14310582	14	13	14	5	4	3	3	2	2	0	0.80	0.97
509	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(2), EPHB2(1), F2(2), F2RL2(1), JUN(1), MAP2K5(1), MAPK1(1), MAPK8(2), MYEF2(1), PLD1(1), PLD3(1), PTK2(1), RAF1(1), RASAL1(1), TEC(1), VAV1(1)	19738524	19	18	19	5	1	9	3	3	3	0	0.81	0.97
510	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK1(1), JAK2(2), STAT1(1)	6231537	4	4	4	1	0	0	0	1	3	0	0.81	0.97
511	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(2), CS(1), DLD(1), IDH3A(1), IDH3G(1), MDH2(2), OGDH(1), PC(1), PDHA1(1), PDHA2(1), PDHB(1), PDHX(1), PDK1(1), PDK2(1), PDK4(1), PDP2(1), SDHA(1), SDHB(1), SUCLA2(1)	20894484	21	20	21	6	4	8	7	2	0	0	0.81	0.97
512	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(2), PAX3(2), RARA(1), SP100(4), TNFRSF1A(1)	11586978	10	10	10	4	1	3	3	1	2	0	0.81	0.97
513	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), ACO2(2), CS(1), DLD(1), IDH1(1), IDH3A(1), IDH3G(1), MDH2(2), PC(1), PCK1(1), SDHA(1), SDHB(1), SUCLA2(1)	15259179	15	14	15	3	2	6	6	1	0	0	0.81	0.97
514	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(1), ALG10B(3), ALG11(1), ALG13(2), ALG2(1), ALG6(1), ALG9(1), B4GALT1(2), B4GALT3(1), DPAGT1(2), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT3(1), MGAT5(2), MGAT5B(4), RPN1(1)	30462588	29	28	29	13	5	8	6	3	7	0	0.81	0.97
515	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(1), AASDHPPT(2), AASS(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), DOT1L(3), ECHS1(1), EHHADH(2), GCDH(1), PLOD1(1), PLOD2(1), PLOD3(1)	25485369	22	21	22	14	1	9	5	3	4	0	0.82	0.97
516	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(1)	3752814	2	2	2	3	0	0	0	0	2	0	0.82	0.97
517	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLUD2(1)	3079011	2	2	2	1	0	0	1	0	1	0	0.82	0.97
518	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A4(2), ATP6V0B(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), FDXR(3)	11895234	10	10	9	3	2	2	3	1	2	0	0.82	0.97
519	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CTH(1), GOT2(1), LDHC(1)	4869228	3	3	3	0	0	2	0	0	1	0	0.82	0.97
520	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	CDK5(1), CHN1(1), LIMK1(3), MYLK(5), NCF2(2), PAK1(2), PDGFRA(3), PLD1(1), TRIO(2), VAV1(1), WASF1(1)	21331011	22	21	22	12	6	8	5	3	0	0	0.82	0.97
521	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	15	DNAJA3(1), IKBKB(2), JAK2(2), NFKB1(1), RELA(1), TNFRSF1A(1), USH1C(1), WT1(1)	11097723	10	9	10	3	2	4	0	0	4	0	0.82	0.97
522	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(1), HS3ST2(1), XYLT2(1)	4417998	3	3	3	2	1	1	1	0	0	0	0.83	0.97
523	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(1), HS3ST2(1), XYLT2(1)	4417998	3	3	3	2	1	1	1	0	0	0	0.83	0.97
524	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(1), UCHL3(1), UGT1A10(1), UGT1A6(2), UGT2B15(2), UGT2B4(1)	12038715	10	10	10	5	2	2	3	1	2	0	0.83	0.97
525	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(3), COL4A1(4), COL4A2(2), COL4A3(1), COL4A4(1), COL4A5(4), COL4A6(3)	19148376	19	17	19	8	3	7	6	0	3	0	0.83	0.97
526	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), CS(1), PC(1), PDHA1(1)	6708624	5	5	5	2	0	3	1	1	0	0	0.83	0.97
527	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	DARS(1), EPRS(2), FARS2(1), GARS(1), IARS(5), LARS2(2), NARS(1), QARS(2), RARS(1), SARS(2), TARS(4), WARS2(1)	23973495	23	22	23	6	3	7	7	2	4	0	0.84	0.97
528	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	EGF(2), EGFR(4), GRB2(1), MET(4), PDGFRA(3)	14554956	14	12	14	4	3	3	1	4	0	3	0.84	0.97
529	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	APC(3), CREBBP(2), EP300(3), MAP2K1(1), MAPK3(1), SKIL(1), TGFB3(1), TGFBR1(2)	17709003	14	14	13	5	1	5	4	1	3	0	0.84	0.97
530	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1), APOBEC2(1), APOBEC3B(1), APOBEC4(1)	5493345	4	4	4	1	0	2	1	0	1	0	0.84	0.97
531	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	GLB1(1), HEXB(1), LCT(3), MAN2B1(2), MAN2B2(3), MANBA(1), NEU2(1)	14468259	12	12	12	4	0	2	7	1	2	0	0.84	0.97
532	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	11	BAD(1), GHR(2), NFKB1(1), RELA(1)	7084311	5	5	5	1	1	2	1	0	1	0	0.84	0.97
533	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(1), ACO2(2), CLYBL(2), CS(1), DLD(1), IDH1(1), IDH3A(1), IDH3G(1), MDH2(2), OGDH(1), OGDHL(1), PC(1), PCK1(1), PCK2(1), SDHA(1), SDHB(1), SUCLA2(1)	22200516	22	20	22	5	2	11	7	2	0	0	0.84	0.97
534	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	16	IKBKB(2), IL2(1), JUN(1), MAP3K5(1), MAPK14(1), MAPK8(2), NFKB1(1), RELA(1)	12418458	10	10	10	3	1	5	1	0	3	0	0.85	0.98
535	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), NDUFA13(1)	2989272	2	2	2	0	0	2	0	0	0	0	0.85	0.98
536	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACAT1(1), ECHS1(1)	3846609	2	2	2	3	0	1	0	1	0	0	0.86	0.99
537	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	10	GRB2(1), IL2RG(1), IRS1(1), JAK1(1), JAK3(1), SHC1(1)	10354968	6	6	6	3	0	2	1	1	2	0	0.86	0.99
538	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(1), ACADSB(1), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), AOX1(3), BCAT1(3), BCKDHA(1), ECHS1(1), EHHADH(2), HADHB(1), MCCC1(2), OXCT1(1), PCCA(1)	25785513	24	23	24	10	3	10	7	2	2	0	0.86	0.99
539	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	27	DGKA(3), ITPR1(7), ITPR3(4), MAP2K1(1), MAPK1(1), MAPK3(1), PAK1(2), PDE3A(6), PDE3B(1), PI3(1), PIK3C2G(1), RIPK3(1), RPS4X(1)	31614999	30	28	30	13	5	10	6	4	5	0	0.86	0.99
540	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF5(1)	8609367	5	5	5	3	2	1	1	0	1	0	0.86	0.99
541	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	19	APC(3), CERK(1), CREB3(1), EPHB2(1), GNAQ(1), JUN(1), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1)	16043001	13	13	13	4	2	5	2	0	4	0	0.87	0.99
542	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(4), NRG3(1)	6545370	5	5	5	2	2	2	1	0	0	0	0.87	0.99
543	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	26	CCR3(1), CCR7(2), CD4(1), IL12A(1), IL12B(1), IL12RB1(2), IL18R1(1), IL2(1), TGFB3(1)	14100177	11	11	11	6	1	3	2	1	4	0	0.87	0.99
544	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	14	MAP2K3(1), MAPK14(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	6891144	5	5	5	5	2	2	0	1	0	0	0.87	0.99
545	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACAT1(1), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), AOX1(3), CARM1(1), CYP1B1(1), DDC(1), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HSD17B10(1), HSD17B4(3), INMT(1), KYNU(1), LCMT1(1), LCMT2(3), LNX1(1), MAOA(2), METTL2B(2), OGDH(1), OGDHL(1), PRMT3(2), PRMT5(2), PRMT6(2), PRMT7(1), PRMT8(1), WARS2(1)	44382780	43	38	43	20	5	15	14	2	7	0	0.88	0.99
546	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA5(1), PSMB6(1), PSMD1(4), PSMD2(1), PSMD6(2)	11864814	9	9	9	3	2	2	3	0	2	0	0.88	0.99
547	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	20	ARSB(3), ARSE(1), GLA(2), GLB1(1), LCT(3), NEU2(1), PPAP2A(1), SMPD2(2), SPTLC1(1), SPTLC2(2)	16675230	17	14	17	2	3	6	5	1	2	0	0.88	0.99
548	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	17	APAF1(1), BAK1(1), CASP6(1), CASP8(2), DFFB(2)	9558471	7	7	7	0	2	2	1	0	2	0	0.88	0.99
549	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(1), RANGAP1(2)	6114420	4	4	4	0	1	0	1	1	1	0	0.88	0.99
550	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), CAMK2A(1), CAMK2D(3), CNGA3(3), CNGA4(2), GUCA1A(1), GUCA1C(1), PRKACA(1), PRKG1(1), PRKG2(4)	22180743	19	19	19	10	4	4	5	4	2	0	0.89	0.99
551	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(2), EP300(3), LPL(1), NCOA1(1), NCOA2(1), PPARG(1)	13479609	9	9	8	4	2	1	1	1	4	0	0.89	0.99
552	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), PPARG(1)	4189848	2	2	2	1	1	0	1	0	0	0	0.89	0.99
553	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1)	2775318	1	1	1	0	1	0	0	0	0	0	0.89	0.99
554	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(1), ERCC3(2), GTF2E2(1), GTF2F2(1), ILK(2), MNAT1(1), POLR1A(1), POLR1B(2), POLR2A(2), POLR2B(3), POLR2H(1), POLR3B(2), POLR3E(2), TAF6(1), TAF7(1), TBP(1)	26232180	24	22	24	11	4	7	7	0	6	0	0.89	0.99
555	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	36	APAF1(1), BAK1(1), CASP2(2), CASP6(1), CASP8(2), FAS(1), FASLG(1), JUN(1), MAPK10(1), MDM2(1), MYC(1), NFKB1(1), PARP1(1), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1)	23509083	22	20	22	6	3	9	2	2	6	0	0.89	0.99
556	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1)	3155061	1	1	1	1	0	1	0	0	0	0	0.90	0.99
557	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(2), AASS(3), ACAT1(1), ALDH1B1(1), ALDH9A1(1), DOT1L(3), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HSD17B10(1), HSD17B4(3), OGDH(1), OGDHL(1), PIPOX(1), PLOD1(1), PLOD2(1), PLOD3(1), RDH11(2), RDH12(1), RDH14(1), SETD7(1), SETDB1(7)	41347878	38	37	37	18	6	14	9	4	5	0	0.90	0.99
558	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	15	ALOX12(1), GGT1(1), PLA2G6(2), PTGDS(1), PTGS2(1), TBXAS1(1)	9843912	7	7	7	1	0	4	2	0	1	0	0.90	0.99
559	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	17	EIF4A2(3), EIF4B(1), EIF4G2(1), EIF4G3(2), PDK2(1), RPS6(1), TSC1(2), TSC2(2)	14889069	13	12	13	5	2	5	2	2	2	0	0.91	1.00
560	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	15	EIF2B5(1), EIF2S1(1), EIF2S2(1), IGF1(1), IGF1R(1), INPPL1(1), PDK2(1), RPS6(1)	10549149	8	8	8	8	4	1	2	0	1	0	0.91	1.00
561	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADVL(2), ACSL3(1), ACSL4(1), CPT1A(2), CPT2(1), EHHADH(2), SLC25A20(1)	12381447	10	10	10	7	1	6	3	0	0	0	0.91	1.00
562	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	4	GNAQ(1)	2682537	1	1	1	0	0	1	0	0	0	0	0.91	1.00
563	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(2), CS(1), OGDH(1), SDHA(1), SUCLA2(1)	7055919	6	5	6	2	1	2	2	1	0	0	0.91	1.00
564	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	46	ACTG1(1), APAF1(1), ARHGDIB(1), BAG4(1), CASP2(2), CASP6(1), CASP8(2), DFFB(2), GSN(1), LMNB1(1), MAP3K5(1), MAPK8(2), MDM2(1), NFKB1(1), NUMA1(2), PAK2(1), PRKDC(7), PSEN2(2), PTK2(1), RASA1(2), RELA(1), RIPK1(3), SPTAN1(2), TNFRSF1A(1)	46932483	40	38	40	6	5	15	10	2	8	0	0.91	1.00
565	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT1(2), B4GALT3(1), DPAGT1(2), MAN1B1(1), MGAT3(1), MGAT5(2), RPN1(1)	13911066	10	10	10	3	0	4	2	1	3	0	0.92	1.00
566	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLB(1), POLD2(1), POLD4(1), POLE2(1), POLE3(1), POLG(1), POLH(2), POLI(3), POLL(1), POLQ(4), REV1(1), REV3L(4)	31128279	25	24	25	7	3	8	5	3	6	0	0.92	1.00
567	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(1), BAD(1), CASP1(1), CASP2(2), CASP6(1), CASP8(2), CD40(1), CD40LG(1), DFFB(2), FAS(1), FASLG(1), IKBKE(1), NFKB1(1), NGFR(1), NTRK1(1), PTPN13(4), RIPK1(3), SFRS2IP(1), TNFRSF1A(1), TRAF6(1)	32007924	28	26	28	5	9	9	2	2	6	0	0.92	1.00
568	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	13	ADSL(1), IMPDH1(2), POLB(1), POLG(1), PRPS2(1)	8741187	6	6	6	3	2	2	0	1	1	0	0.93	1.00
569	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	11	IKBKAP(3), IKBKB(2), NFKB1(1), RELA(1), TNFAIP3(1), TRAF6(1)	11337534	9	8	9	4	1	6	1	0	1	0	0.93	1.00
570	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	MAPK14(1), MAPK8(2), NFKB1(1), RELA(1), TNFSF13B(1), TRAF6(1)	10531404	7	7	7	1	1	4	0	0	2	0	0.93	1.00
571	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	APC(3), EPHB2(1), GNAI1(1), GNAQ(1), ITPR1(7), ITPR3(4), KCNJ3(1), MAPK1(1), PITX2(1), PTX3(1), RHO(2), RYR1(5)	33765186	28	27	28	12	7	8	5	1	7	0	0.93	1.00
572	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(3), PRKAR2A(1), PRKAR2B(1)	7388004	5	5	5	3	2	2	0	1	0	0	0.93	1.00
573	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS2(1), CDO1(1), CTH(1), GOT2(1), LDHC(1)	8927256	5	5	5	1	0	2	1	0	2	0	0.93	1.00
574	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH7(2), ADHFE1(1), ALDH1B1(1), ALDH9A1(1)	9670011	6	6	6	2	0	5	1	0	0	0	0.93	1.00
575	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CREBBP(2), EP300(3), IKBKB(2), MAP2K3(1), MAPK14(1), NFKB1(1), RELA(1), TGFBR1(2), TLR2(1)	21208317	14	14	13	4	1	6	1	1	5	0	0.94	1.00
576	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(3), ACACA(1), ACACB(8), ACAT1(1), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HIBCH(2), LDHC(1), MLYCD(2), PCCA(1), SUCLA2(1)	29235141	25	24	25	7	4	12	7	1	1	0	0.94	1.00
577	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	FURIN(1)	3715803	1	1	1	2	0	0	0	1	0	0	0.94	1.00
578	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(3), BCHE(1), CES1(1), CYP3A4(3), UGT1A10(1), UGT1A6(2)	17340921	14	14	14	6	4	3	6	0	1	0	0.94	1.00
579	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	41	EPHB2(1), FBXW7(1), GRB2(1), ITK(3), LAT(1), LCP2(1), MAPK1(1), NFAT5(1), NFKB1(1), NFKB2(4), PAK1(2), PAK2(1), PAK3(1), PAK7(1), PLCG1(4), PTPRC(1), RAF1(1), RASGRP2(2), RASGRP4(1), SOS1(3), SOS2(1), VAV1(1), ZAP70(1)	38677509	35	30	35	12	9	12	4	3	4	3	0.94	1.00
580	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	16	IKBKAP(3), IKBKB(2), NFKB1(1), RELA(1), RIPK1(3), TANK(1), TNFAIP3(1)	14520987	12	11	12	5	1	7	2	0	2	0	0.95	1.00
581	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	31	GTF2E2(1), GTF2F2(1), TAF1(6), TAF1L(6), TAF4B(2), TAF5L(1), TAF6(1), TAF7(1), TBPL2(2)	26955162	21	21	20	5	4	5	8	0	4	0	0.95	1.00
582	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(2), ATP6V0B(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1)	11287848	7	7	7	3	2	0	2	1	2	0	0.95	1.00
583	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(2), ATP6V0B(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1)	11287848	7	7	7	3	2	0	2	1	2	0	0.95	1.00
584	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(2), ATP6V0B(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1)	11287848	7	7	7	3	2	0	2	1	2	0	0.95	1.00
585	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(3), AXIN1(1), CREBBP(2), EP300(3), FZD1(1), HDAC1(2), PITX2(1), TRRAP(3)	23100948	16	15	15	8	2	3	4	2	5	0	0.96	1.00
586	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	PTGS2(1)	3974880	1	1	1	0	0	1	0	0	0	0	0.96	1.00
587	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	GLB1(1), HEXB(1), LCT(3), MANBA(1), NEU2(1)	11744148	7	7	7	1	0	2	3	0	2	0	0.96	1.00
588	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFB(2), HMGB2(1), TOP2A(1)	7465575	4	4	4	0	2	1	0	1	0	0	0.96	1.00
589	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(1)	4176159	1	1	1	1	0	1	0	0	0	0	0.96	1.00
590	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA5(1), PSMB6(1), PSMB8(1)	6472869	3	3	3	0	1	0	2	0	0	0	0.96	1.00
591	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD2(1), POLG(1), POLL(1), POLQ(4)	12519351	8	8	8	1	0	5	0	1	2	0	0.97	1.00
592	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(1), BAD(1), BAK1(1), BCL2L11(1), CES1(1)	8241792	5	5	5	0	3	2	0	0	0	0	0.97	1.00
593	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	APAF1(1), FAS(1), FASLG(1), IL1A(1), MAPKAPK3(1)	8080059	5	5	5	1	4	1	0	0	0	0	0.97	1.00
594	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(3), ACACA(1), ACADSB(1), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), LDHC(1), MLYCD(2), PCCA(1), SUCLA2(1)	24317241	19	18	19	9	1	10	5	2	1	0	0.97	1.00
595	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	24	MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), NFKB1(1), NFKB2(4), TRAF6(1)	17053959	13	11	13	4	1	7	0	0	2	3	0.97	1.00
596	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA5(1), PSMB6(1), RPN1(1), UBE2A(1), UBE3A(1)	9834279	5	5	5	1	0	1	3	0	1	0	0.97	1.00
597	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(3), GRM1(2), GRM2(1), GRM3(3), GRM4(1), GRM5(1), GRM8(1)	15237885	12	11	12	6	6	2	2	1	1	0	0.97	1.00
598	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR6(1), TPK1(1)	4689750	2	2	2	0	1	1	0	0	0	0	0.98	1.00
599	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	20	APC(3), AXIN1(1), CCND1(1), CREBBP(2), CSNK2A1(1), FZD1(1), HDAC1(2), MYC(1), NLK(1), WIF1(1)	19757283	14	13	14	7	2	5	2	3	2	0	0.98	1.00
600	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(1), ACACB(8), ACAT1(1), ACYP1(1), AKR1B1(2), ALDH1B1(1), ALDH9A1(1), DLD(1), LDHC(1), MDH2(2), ME2(1), ME3(1), PC(1), PCK1(1), PCK2(1), PDHA1(1), PDHA2(1), PDHB(1)	33688629	27	26	27	4	6	16	4	0	1	0	0.98	1.00
601	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(1), UGT1A10(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B15(2), UGT2B28(1), UGT2B4(1)	18672810	13	13	13	8	4	2	5	0	2	0	0.98	1.00
602	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	11	CNR1(1), PTGDR(1), PTGFR(1)	7365189	3	3	3	5	0	0	3	0	0	0	0.98	1.00
603	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(1), PPOX(1)	5778279	2	2	2	2	1	0	1	0	0	0	0.98	1.00
604	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(1), ALDH9A1(1)	5833035	2	2	2	1	0	2	0	0	0	0	0.98	1.00
605	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS2(1), COX10(2), CP(2), EARS2(3), EPRS(2), GUSB(1), PPOX(1), UGT1A10(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B15(2), UGT2B28(1), UGT2B4(1)	29682822	22	21	22	11	7	2	8	1	4	0	0.99	1.00
606	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(1), ACAT1(1), ACYP1(1), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1B1(1), ALDH9A1(1), DLD(1), LDHC(1), MDH2(2), ME2(1), ME3(1), PC(1), PCK1(1), PDHA1(1), PDHA2(1), PDHB(1)	26318370	21	19	21	6	3	14	3	0	1	0	0.99	1.00
607	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	25	BAG4(1), CASP8(2), JUN(1), NFKB1(1), NFKB2(4), RIPK1(3), TNFAIP3(1), TNFRSF1A(1)	18483699	14	11	14	8	2	4	1	0	4	3	0.99	1.00
608	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	40	CDC7(1), CDK2(1), MCM10(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), NACA(3), ORC2L(1), ORC3L(1), POLD2(1), POLD4(1), POLE2(1), RFC1(2), RFC4(3), RPA1(1)	35364264	25	24	25	8	6	7	6	1	3	2	0.99	1.00
609	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	APC(3), AXIN1(1), FZD1(1)	11563656	5	5	5	7	0	2	2	1	0	0	0.99	1.00
610	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(1), ANAPC5(4), ANAPC7(1), CDC23(1), CDC27(1), CUL1(1), FBXW7(1), SMURF2(1), UBA1(3), UBE2D2(2), WWP2(4)	29671161	20	20	20	7	4	9	3	1	3	0	0.99	1.00
611	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	CP(2), EPRS(2), GUSB(1), PPOX(1), UGT1A10(1), UGT1A6(2), UGT2B15(2), UGT2B4(1)	19384638	12	11	12	6	3	2	4	1	2	0	1.00	1.00
612	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	10	ALAS2(1)	5981079	1	1	1	2	1	0	0	0	0	0	1.00	1.00
613	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	30	APAF1(1), CASP6(1), CASP8(2), DFFB(2), NFKB1(1), RELA(1), RIPK1(3), SPTAN1(2)	23737233	13	12	13	2	1	6	2	0	4	0	1.00	1.00
614	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	22	GPLD1(2), PGAP1(2), PIGA(1), PIGB(1), PIGG(1)	17040270	7	7	7	3	1	3	2	1	0	0	1.00	1.00
615	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		1220856	0	0	0	0	0	0	0	0	0	0	1.00	1.00
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		384306	0	0	0	0	0	0	0	0	0	0	1.00	1.00
