Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.016 0.115 -9999.0 0.0 -0.553 6.0 6.0 IHH 0.027 0.094 -9999.0 0.0 -0.432 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.074 0.142 -9999.0 0.0 -0.303 49.0 49.0 LRPAP1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.074 0.141 0.301 49.0 -9999.0 0.0 49.0 SMO/beta Arrestin2 0.007 0.12 -9999.0 0.0 -0.377 11.0 11.0 SMO -0.007 0.115 -9999.0 0.0 -0.338 20.0 20.0 AKT1 -0.023 0.16 -9999.0 0.0 -0.518 12.0 12.0 ARRB2 0.026 0.038 -9999.0 0.0 -0.484 1.0 1.0 BOC 0.027 0.056 -9999.0 0.0 -0.243 8.0 8.0 ADRBK1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.007 0.114 -9999.0 0.0 -0.333 20.0 20.0 STIL -0.002 0.109 0.352 2.0 -0.269 14.0 16.0 DHH N/PTCH2 0.053 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.029 0.075 -9999.0 0.0 -0.297 9.0 9.0 PIK3CA 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.004 0.165 -9999.0 0.0 -0.867 6.0 6.0 determination of left/right symmetry -0.007 0.114 -9999.0 0.0 -0.333 20.0 20.0 PIK3R1 0.03 0.061 -9999.0 0.0 -0.484 3.0 3.0 skeletal system development 0.004 0.163 -9999.0 0.0 -0.855 6.0 6.0 IHH N/Hhip -0.013 0.16 -9999.0 0.0 -0.387 30.0 30.0 DHH N/Hhip -0.004 0.133 -9999.0 0.0 -0.35 25.0 25.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.007 0.114 -9999.0 0.0 -0.333 20.0 20.0 pancreas development -0.034 0.17 -9999.0 0.0 -0.41 34.0 34.0 HHAT -0.003 0.132 -9999.0 0.0 -0.411 19.0 19.0 PI3K 0.047 0.049 -9999.0 0.0 -0.35 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.12 0.203 -9999.0 0.0 -0.331 92.0 92.0 somite specification -0.007 0.114 -9999.0 0.0 -0.333 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.006 0.093 -9999.0 0.0 -0.251 24.0 24.0 SHH Np/Cholesterol/PTCH2 0.009 0.083 -9999.0 0.0 -0.275 15.0 15.0 SHH Np/Cholesterol/Megalin 0.008 0.083 -9999.0 0.0 -0.275 15.0 15.0 SHH -0.012 0.098 -9999.0 0.0 -0.357 15.0 15.0 catabolic process 0.008 0.077 -9999.0 0.0 -0.332 9.0 9.0 SMO/Vitamin D3 -0.016 0.11 -9999.0 0.0 -0.33 14.0 14.0 SHH Np/Cholesterol/Hhip -0.031 0.132 -9999.0 0.0 -0.307 35.0 35.0 LRP2 0.035 0.024 -9999.0 0.0 -0.209 2.0 2.0 receptor-mediated endocytosis -0.016 0.106 -9999.0 0.0 -0.321 14.0 14.0 SHH Np/Cholesterol/BOC 0.004 0.085 -9999.0 0.0 -0.276 15.0 15.0 SHH Np/Cholesterol/CDO 0.008 0.083 -9999.0 0.0 -0.275 15.0 15.0 mesenchymal cell differentiation 0.031 0.131 0.305 35.0 -9999.0 0.0 35.0 mol:Vitamin D3 0.005 0.107 0.231 11.0 -0.251 24.0 35.0 IHH N/PTCH2 0.046 0.062 -9999.0 0.0 -0.319 5.0 5.0 CDON 0.035 0.024 -9999.0 0.0 -0.209 2.0 2.0 IHH N/PTCH1 0.028 0.083 -9999.0 0.0 -0.335 9.0 9.0 Megalin/LRPAP1 0.052 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.004 0.077 -9999.0 0.0 -0.274 15.0 15.0 PTCH1 0.008 0.078 -9999.0 0.0 -0.333 9.0 9.0 HHIP -0.034 0.17 -9999.0 0.0 -0.411 34.0 34.0