Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.007 0.071 -9999.0 0.0 -0.242 15.0 15.0 epithelial cell differentiation 0.045 0.093 -9999.0 0.0 -0.259 15.0 15.0 CYFIP2 0.012 0.111 -9999.0 0.0 -0.459 11.0 11.0 ENAH -0.041 0.083 0.278 1.0 -0.357 5.0 6.0 EGFR 0.016 0.088 -9999.0 0.0 -0.415 8.0 8.0 EPHA2 0.013 0.087 -9999.0 0.0 -0.282 15.0 15.0 MYO6 -0.008 0.081 -9999.0 0.0 -0.251 18.0 18.0 CTNNB1 0.014 0.092 -9999.0 0.0 -0.301 15.0 15.0 ABI1/Sra1/Nap1 0.047 0.089 -9999.0 0.0 -0.308 10.0 10.0 AQP5 -0.021 0.091 -9999.0 0.0 -0.362 9.0 9.0 CTNND1 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.004 0.073 -9999.0 0.0 -0.247 15.0 15.0 regulation of calcium-dependent cell-cell adhesion -0.04 0.102 -9999.0 0.0 -0.248 35.0 35.0 EGF -0.094 0.19 -9999.0 0.0 -0.32 79.0 79.0 NCKAP1 0.023 0.068 -9999.0 0.0 -0.264 10.0 10.0 AQP3 -0.036 0.108 -9999.0 0.0 -0.42 10.0 10.0 cortical microtubule organization 0.045 0.093 -9999.0 0.0 -0.259 15.0 15.0 GO:0000145 -0.026 0.063 -9999.0 0.0 -0.237 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.052 0.096 -9999.0 0.0 -0.261 15.0 15.0 MLLT4 0.022 0.086 -9999.0 0.0 -0.484 6.0 6.0 ARF6/GDP -0.05 0.087 -9999.0 0.0 -0.364 8.0 8.0 ARF6 0.029 0.051 -9999.0 0.0 -0.484 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.048 0.097 -9999.0 0.0 -0.28 12.0 12.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.014 0.074 -9999.0 0.0 -0.294 3.0 3.0 PVRL2 0.033 0.042 -9999.0 0.0 -0.301 3.0 3.0 ZYX -0.006 0.078 -9999.0 0.0 -0.249 17.0 17.0 ARF6/GTP 0.048 0.103 -9999.0 0.0 -0.272 13.0 13.0 CDH1 0.013 0.11 -9999.0 0.0 -0.484 10.0 10.0 EGFR/EGFR/EGF/EGF -0.041 0.136 -9999.0 0.0 -0.271 43.0 43.0 RhoA/GDP 0.048 0.091 -9999.0 0.0 -0.248 15.0 15.0 actin cytoskeleton organization -0.03 0.071 -9999.0 0.0 -0.248 14.0 14.0 IGF-1R heterotetramer 0.031 0.04 -9999.0 0.0 -0.346 2.0 2.0 GIT1 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.031 0.04 -9999.0 0.0 -0.346 2.0 2.0 IGF1 0.016 0.082 -9999.0 0.0 -0.264 15.0 15.0 DIAPH1 0.027 0.184 -9999.0 0.0 -0.639 11.0 11.0 Wnt receptor signaling pathway -0.045 0.093 0.259 15.0 -9999.0 0.0 15.0 RHOA 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.049 0.086 -9999.0 0.0 -0.4 6.0 6.0 CTNNA1 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.031 0.072 -9999.0 0.0 -0.253 14.0 14.0 EFNA1 0.023 0.076 -9999.0 0.0 -0.366 7.0 7.0 LPP -0.026 0.063 -9999.0 0.0 -0.313 1.0 1.0 Ephrin A1/EPHA2 0.017 0.118 -9999.0 0.0 -0.3 20.0 20.0 SEC6/SEC8 -0.011 0.092 -9999.0 0.0 -0.401 7.0 7.0 MGAT3 -0.041 0.104 -9999.0 0.0 -0.251 35.0 35.0 HGF/MET 0.031 0.098 -9999.0 0.0 -0.262 17.0 17.0 HGF 0.031 0.043 -9999.0 0.0 -0.301 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.007 0.071 -9999.0 0.0 -0.243 15.0 15.0 actin cable formation -0.025 0.092 0.265 2.0 -0.319 5.0 7.0 KIAA1543 -0.034 0.077 -9999.0 0.0 -0.41 3.0 3.0 KIFC3 -0.006 0.078 -9999.0 0.0 -0.25 16.0 16.0 NCK1 0.027 0.07 -9999.0 0.0 -0.484 4.0 4.0 EXOC3 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.004 0.074 -9999.0 0.0 -0.25 15.0 15.0 NCK1/GIT1 0.044 0.056 -9999.0 0.0 -0.35 4.0 4.0 mol:GDP 0.045 0.093 -9999.0 0.0 -0.259 15.0 15.0 EXOC4 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.029 0.063 -9999.0 0.0 -0.248 15.0 15.0 PIP5K1C -0.004 0.074 -9999.0 0.0 -0.25 15.0 15.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.035 0.087 0.3 1.0 -0.397 4.0 5.0 adherens junction assembly -0.018 0.09 -9999.0 0.0 -0.469 2.0 2.0 IGF-1R heterotetramer/IGF1 0.021 0.099 -9999.0 0.0 -0.252 19.0 19.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.075 -9999.0 0.0 -0.35 7.0 7.0 MET 0.028 0.055 -9999.0 0.0 -0.346 4.0 4.0 PLEKHA7 -0.003 0.074 -9999.0 0.0 -0.25 15.0 15.0 mol:GTP 0.046 0.096 -9999.0 0.0 -0.278 12.0 12.0 establishment of epithelial cell apical/basal polarity -0.032 0.089 -9999.0 0.0 -0.386 7.0 7.0 cortical actin cytoskeleton stabilization 0.007 0.071 -9999.0 0.0 -0.242 15.0 15.0 regulation of cell-cell adhesion -0.03 0.071 -9999.0 0.0 -0.248 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.007 0.071 -9999.0 0.0 -0.243 15.0 15.0