Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 KIRREL 0.019 0.013 -9999.0 0.0 -0.117 5.0 5.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PLCG1 0.017 0.025 -9999.0 0.0 -0.292 3.0 3.0 ARRB2 0.013 0.039 -9999.0 0.0 -0.292 7.0 7.0 WASL 0.016 0.03 -9999.0 0.0 -0.292 5.0 5.0 Nephrin/NEPH1/podocin/CD2AP 0.036 0.044 -9999.0 0.0 -0.153 19.0 19.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.026 0.047 -9999.0 0.0 -0.231 12.0 12.0 FYN 0.021 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.045 0.02 -9999.0 0.0 -0.172 3.0 3.0 mol:DAG 0.046 0.02 -9999.0 0.0 -0.173 3.0 3.0 NPHS2 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.046 0.02 -9999.0 0.0 -0.173 3.0 3.0 regulation of endocytosis 0.027 0.045 -9999.0 0.0 -0.166 9.0 9.0 Nephrin/NEPH1/podocin/Cholesterol 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 establishment of cell polarity 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2 0.047 0.046 -9999.0 0.0 -0.16 21.0 21.0 Nephrin/NEPH1/beta Arrestin2 0.028 0.046 -9999.0 0.0 -0.167 9.0 9.0 NPHS1 0.02 0.006 -9999.0 0.0 -0.108 1.0 1.0 Nephrin/NEPH1/podocin 0.023 0.04 -9999.0 0.0 -0.084 63.0 63.0 TJP1 0.01 0.046 -9999.0 0.0 -0.193 22.0 22.0 NCK1 0.014 0.036 -9999.0 0.0 -0.189 14.0 14.0 NCK2 0.009 0.054 -9999.0 0.0 -0.282 17.0 17.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.047 0.02 -9999.0 0.0 -0.173 3.0 3.0 CD2AP 0.003 0.062 -9999.0 0.0 -0.197 40.0 40.0 Nephrin/NEPH1/podocin/GRB2 0.045 0.029 -9999.0 0.0 -0.176 8.0 8.0 GRB2 0.014 0.039 -9999.0 0.0 -0.256 10.0 10.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.021 0.016 -9999.0 0.0 -0.079 1.0 1.0 cytoskeleton organization 0.028 0.044 -9999.0 0.0 -0.224 12.0 12.0 Nephrin/NEPH1 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/ZO-1 0.032 0.033 -9999.0 0.0 -0.176 10.0 10.0