E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.007 0.071 -9999.0 0.0 -0.291 22.0 22.0 KLHL20 0.048 0.09 0.205 58.0 -0.189 16.0 74.0 CYFIP2 0.031 0.013 -9999.0 0.0 0.0 78.0 78.0 Rac1/GDP 0.007 0.061 0.203 1.0 -0.286 10.0 11.0 ENAH 0.007 0.074 -9999.0 0.0 -0.311 21.0 21.0 AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 0.0 62.0 -0.0 12.0 74.0 RAP1A 0.036 0.005 -9999.0 0.0 0.0 11.0 11.0 CTNNB1 0.036 0.006 -9999.0 0.0 0.0 15.0 15.0 CDC42/GTP -0.026 0.052 0.119 13.0 -0.213 18.0 31.0 ABI1/Sra1/Nap1 -0.014 0.033 -9999.0 0.0 -0.135 27.0 27.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.084 0.036 -9999.0 0.0 -0.128 8.0 8.0 RAPGEF1 -0.006 0.074 -9999.0 0.0 -0.287 18.0 18.0 CTNND1 0.034 0.009 -9999.0 0.0 0.0 32.0 32.0 regulation of calcium-dependent cell-cell adhesion 0.02 0.076 -9999.0 0.0 -0.291 23.0 23.0 CRK -0.0 0.076 0.195 1.0 -0.29 22.0 23.0 E-cadherin/gamma catenin/alpha catenin 0.061 0.035 -9999.0 0.0 -0.123 8.0 8.0 alphaE/beta7 Integrin 0.049 0.025 -9999.0 0.0 -0.141 7.0 7.0 IQGAP1 0.033 0.011 -9999.0 0.0 0.0 51.0 51.0 NCKAP1 0.036 0.002 -9999.0 0.0 0.0 2.0 2.0 Rap1/GTP/I-afadin 0.043 0.015 -9999.0 0.0 -0.101 1.0 1.0 DLG1 0.007 0.075 -9999.0 0.0 -0.295 23.0 23.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.035 0.044 -9999.0 0.0 -0.177 30.0 30.0 MLLT4 0.034 0.009 -9999.0 0.0 0.0 36.0 36.0 ARF6/GTP/NME1/Tiam1 0.036 0.033 -9999.0 0.0 -0.1 23.0 23.0 PI3K -0.043 0.058 0.059 2.0 -0.227 30.0 32.0 ARF6 0.035 0.008 -9999.0 0.0 0.0 27.0 27.0 mol:Ca2+ 0.0 0.0 0.001 69.0 -0.0 28.0 97.0 E-cadherin/gamma catenin 0.048 0.018 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.033 0.011 -9999.0 0.0 0.0 46.0 46.0 E-cadherin(dimer)/Ca2+ 0.07 0.054 -9999.0 0.0 -0.137 25.0 25.0 AKT1 -0.023 0.052 0.132 7.0 -0.178 24.0 31.0 PIK3R1 0.032 0.012 -9999.0 0.0 0.0 63.0 63.0 CDH1 0.034 0.01 -9999.0 0.0 0.0 38.0 38.0 RhoA/GDP 0.011 0.07 0.193 2.0 -0.266 12.0 14.0 actin cytoskeleton organization 0.04 0.072 0.168 62.0 -0.139 16.0 78.0 CDC42/GDP 0.011 0.068 0.193 2.0 -0.263 11.0 13.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.049 -9999.0 0.0 -0.195 23.0 23.0 ITGB7 0.036 0.005 -9999.0 0.0 0.0 11.0 11.0 RAC1 0.024 0.017 -9999.0 0.0 0.0 173.0 173.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.077 0.057 -9999.0 0.0 -0.147 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.056 0.031 -9999.0 0.0 -0.11 10.0 10.0 mol:GDP -0.006 0.071 0.187 2.0 -0.296 12.0 14.0 CDC42/GTP/IQGAP1 0.035 0.042 -9999.0 0.0 -0.115 33.0 33.0 JUP 0.033 0.011 -9999.0 0.0 0.0 51.0 51.0 p120 catenin/RhoA/GDP 0.026 0.077 0.207 1.0 -0.257 15.0 16.0 RAC1/GTP/IQGAP1 0.023 0.042 -9999.0 0.0 -0.116 30.0 30.0 PIP5K1C/AP1M1 0.02 0.03 -9999.0 0.0 -0.131 18.0 18.0 RHOA 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 CDC42 0.035 0.008 -9999.0 0.0 0.0 24.0 24.0 CTNNA1 0.035 0.007 -9999.0 0.0 0.0 20.0 20.0 positive regulation of S phase of mitotic cell cycle 0.014 0.045 0.112 8.0 -0.127 26.0 34.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 32.0 32.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.008 0.072 -9999.0 0.0 -0.302 20.0 20.0 regulation of cell-cell adhesion -0.028 0.04 -9999.0 0.0 -0.17 25.0 25.0 WASF2 -0.008 0.018 -9999.0 0.0 -0.074 27.0 27.0 Rap1/GTP -0.023 0.061 0.149 19.0 -0.247 16.0 35.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.09 0.051 -9999.0 0.0 -0.128 13.0 13.0 CCND1 0.016 0.054 0.128 8.0 -0.155 26.0 34.0 VAV2 0.019 0.101 -9999.0 0.0 -0.543 8.0 8.0 RAP1/GDP -0.011 0.064 0.161 17.0 -0.251 15.0 32.0 adherens junction assembly 0.009 0.071 -9999.0 0.0 -0.293 20.0 20.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.017 -9999.0 0.0 0.0 152.0 152.0 PIP5K1C 0.033 0.011 -9999.0 0.0 0.0 50.0 50.0 regulation of heterotypic cell-cell adhesion 0.068 0.047 0.201 3.0 -0.134 14.0 17.0 E-cadherin/beta catenin 0.006 0.02 -9999.0 0.0 -0.097 5.0 5.0 mol:GTP 0.0 0.0 0.001 64.0 -0.0 32.0 96.0 SRC 0.006 0.073 -9999.0 0.0 -0.289 23.0 23.0 PIK3CA 0.031 0.013 -9999.0 0.0 0.0 80.0 80.0 Rac1/GTP -0.007 0.07 0.184 1.0 -0.283 21.0 22.0 E-cadherin/beta catenin/alpha catenin 0.064 0.036 -9999.0 0.0 -0.132 10.0 10.0 ITGAE 0.035 0.007 -9999.0 0.0 0.0 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.02 0.077 -9999.0 0.0 -0.296 23.0 23.0