rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(6), ATR(12), CDC25C(1), CHEK1(4), CHEK2(3), TP53(115)	4293716	141	122	107	5	26	27	24	18	46	0	<1.00e-15	<2.08e-13
2	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(2), ATM(6), BRCA1(6), CHEK1(4), CHEK2(3), GADD45A(1), JUN(3), MAPK8(2), MDM2(1), NFKB1(2), RAD50(2), RAD51(1), RBBP8(1), RELA(2), TP53(115)	8101670	151	117	116	10	26	33	23	21	48	0	2.55e-15	2.08e-13
3	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(2), ATM(6), ATR(12), CDKN2A(22), E2F1(2), HDAC1(2), RB1(7), SKP2(1), TGFB1(1), TGFB2(2), TP53(115)	8079954	172	131	135	12	29	36	30	16	61	0	2.89e-15	2.08e-13
4	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(1), ATF2(2), CDC42(1), DLD(2), DUSP10(3), DUSP4(2), GAB1(2), GADD45A(1), GCK(1), JUN(3), MAP2K5(1), MAP3K1(2), MAP3K11(2), MAP3K12(3), MAP3K13(5), MAP3K4(4), MAP3K5(3), MAP3K7(2), MAP3K9(3), MAPK10(1), MAPK7(1), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(2), NR2C2(1), PAPPA(8), SHC1(1), TP53(115), TRAF6(1)	13764918	179	131	144	25	35	44	34	20	46	0	3.11e-15	2.08e-13
5	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(2), ANAPC1(4), ANAPC4(3), ANAPC5(4), ATM(6), ATR(12), BUB1(3), BUB1B(6), BUB3(2), CCNB1(1), CCNB3(9), CCND2(3), CCND3(1), CCNE2(2), CDC25B(1), CDC25C(1), CDC27(2), CDC6(4), CDC7(1), CDK7(1), CDKN2A(22), CDKN2C(1), CHEK1(4), CHEK2(3), CREBBP(12), CUL1(2), DBF4(4), E2F1(2), EP300(6), ESPL1(2), GADD45A(1), GADD45G(1), HDAC1(2), MAD1L1(5), MAD2L1(2), MCM2(1), MCM3(1), MCM4(3), MCM5(6), MCM6(1), MCM7(3), MDM2(1), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), PKMYT1(1), PLK1(1), PRKDC(11), PTTG1(1), PTTG2(2), RB1(7), RBL1(5), RBL2(5), RBX1(1), SFN(2), SKP1(1), SKP2(1), SMAD2(1), SMAD4(2), SMC1A(2), SMC1B(4), TGFB1(1), TGFB2(2), TP53(115), WEE1(2), YWHAB(1), YWHAQ(1)	37187582	326	157	288	50	66	90	62	31	77	0	3.66e-15	2.08e-13
6	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(1), BAK1(1), BAX(1), BCL2L1(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(1), CASP9(2), FADD(1), FAS(1), FASLG(1), GZMB(1), JUN(3), MAP3K1(2), MAP3K14(1), MAPK10(1), MCL1(2), MDM2(1), MYC(1), NFKB1(2), PARP1(3), PRF1(1), RELA(2), TNFRSF1A(2), TNFRSF1B(1), TP53(115), TRADD(1), TRAF1(4)	10250308	159	121	124	24	30	32	26	21	50	0	4.00e-15	2.08e-13
7	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(6), ATR(12), BRCA1(6), BRCA2(7), CHEK1(4), CHEK2(3), FANCC(2), FANCF(3), FANCG(1), RAD1(1), RAD17(2), RAD50(2), RAD51(1), RAD9A(1), TP53(115), TREX1(1)	11853198	167	124	133	14	31	36	29	21	50	0	4.77e-15	2.08e-13
8	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(2), ATM(6), BUB1(3), BUB1B(6), BUB3(2), CCNB1(1), CCNB3(9), CCND2(3), CCND3(1), CCNE2(2), CDAN1(3), CDC25B(1), CDC25C(1), CDC6(4), CDC7(1), CDH1(3), CDKN2A(22), CHEK1(4), CHEK2(3), DTX4(1), E2F1(2), EP300(6), ESPL1(2), GADD45A(1), HDAC1(2), HDAC3(1), HDAC4(4), HDAC5(1), MAD1L1(5), MAD2L1(2), MCM2(1), MCM3(1), MCM4(3), MCM5(6), MCM6(1), MCM7(3), MDM2(1), MPEG1(4), MPL(2), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), PLK1(1), PRKDC(11), PTTG1(1), PTTG2(2), RB1(7), RBL1(5), SKP2(1), SMAD4(2), TBC1D8(1), TGFB1(1), TP53(115), WEE1(2)	30149462	279	152	241	42	51	76	54	24	74	0	4.88e-15	2.08e-13
9	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(1), AKT1(1), AKT3(2), APAF1(1), ATM(6), BAX(1), BCL2L1(1), BIRC3(3), CAPN1(2), CAPN2(2), CASP10(3), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHP(2), CHUK(2), CSF2RB(5), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKB(2), IL1B(1), IL1RAP(2), IRAK1(3), IRAK3(3), MAP3K14(1), NFKB1(2), NFKB2(2), NTRK1(3), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(2), TNFRSF10A(1), TNFRSF10B(1), TNFRSF1A(2), TP53(115), TRADD(1)	22576808	246	143	201	44	65	57	34	30	60	0	4.88e-15	2.08e-13
10	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(6), ATR(12), BRCA1(6), CCNB1(1), CDC25B(1), CDC25C(1), CHEK1(4), CHEK2(3), EP300(6), GADD45A(1), MDM2(1), PRKDC(11), RPS6KA1(2), TP53(115), WEE1(2), YWHAQ(1)	11595276	173	129	138	11	32	38	32	22	49	0	5.00e-15	2.08e-13
11	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(6), CCNB1(1), CCND2(3), CCND3(1), CCNE2(2), CDK7(1), CDKN2A(22), CDKN2C(1), CREB3(2), CREB3L3(1), CREB3L4(2), E2F1(2), GADD45A(1), MCM2(1), MCM3(1), MCM4(3), MCM5(6), MCM6(1), MCM7(3), MDM2(1), MYC(1), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), POLE2(2), PRIM1(2), RB1(7), RBL1(5), TFDP2(2), TNXB(15), TP53(115), WEE1(2)	20927638	216	135	179	22	38	54	37	20	67	0	5.11e-15	2.08e-13
12	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(2), CDKN2A(22), E2F1(2), MDM2(1), MYC(1), PIK3CA(20), PIK3R1(1), POLR1A(2), POLR1B(2), POLR1D(1), RAC1(1), RB1(7), TBX2(3), TP53(115)	5437544	180	129	132	13	39	35	29	17	60	0	5.11e-15	2.08e-13
13	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(12), DAXX(2), HRAS(1), PAX3(2), RARA(1), RB1(7), SP100(1), TNFRSF1A(2), TNFRSF1B(1), TP53(115)	5235158	144	120	110	14	26	29	22	17	50	0	6.22e-15	2.08e-13
14	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(15), AKT1(1), ATM(6), BAX(1), CPB2(2), CSNK1A1(2), FHL2(1), GADD45A(1), HIF1A(1), IGFBP3(1), MAPK8(2), MDM2(1), NFKBIB(1), TP53(115)	5676064	150	123	116	7	26	33	28	17	44	2	6.33e-15	2.08e-13
15	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(1), ATM(6), ATR(12), BAI1(8), BAX(1), CASP8(1), CASP9(2), CCNB1(1), CCNB3(9), CCND2(3), CCND3(1), CCNE2(2), CCNG1(1), CD82(1), CDKN2A(22), CHEK1(4), CHEK2(3), DDB2(3), EI24(1), FAS(1), GADD45A(1), GADD45G(1), GTSE1(2), IGF1(3), IGFBP3(1), LRDD(1), MDM2(1), PPM1D(1), PTEN(13), RFWD2(4), RRM2B(2), SERPINB5(2), SESN1(3), SESN2(2), SESN3(2), SFN(2), SIAH1(1), STEAP3(2), THBS1(1), TNFRSF10B(1), TP53(115), TSC2(5)	17798932	249	141	212	22	42	62	47	26	72	0	6.44e-15	2.08e-13
16	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(2), BAK1(1), BAX(1), BTK(4), CAD(8), CASP10(3), CASP8(1), CASP8AP2(5), CDK2AP1(1), CSNK1A1(2), DAXX(2), EGFR(6), EPHB2(4), FADD(1), FAF1(1), FAIM2(1), MAP3K1(2), MAP3K5(3), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MET(3), NFAT5(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), NR0B2(1), PFN2(1), PTPN13(3), RALBP1(1), ROCK1(5), SMPD1(3), TNFRSF6B(1), TP53(115)	20303748	203	134	168	28	41	51	38	20	53	0	6.55e-15	2.08e-13
17	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), MYC(1), SP1(1), SP3(1), TP53(115), WT1(4)	1894810	124	118	90	8	22	21	24	15	42	0	6.88e-15	2.08e-13
18	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IFNG(1), IFNGR1(3), IFNGR2(1), IKBKB(2), JAK2(3), LIN7A(2), NFKB1(2), RB1(7), RELA(2), TNFRSF1A(2), TNFRSF1B(1), TP53(115), USH1C(5), WT1(4)	5076382	150	121	116	9	26	28	30	16	50	0	6.99e-15	2.08e-13
19	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(1), BAK1(1), BAX(1), BCL2L1(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(3), CASP7(2), CASP8(1), CASP9(2), CHUK(2), DFFB(2), FADD(1), FAS(1), FASLG(1), GZMB(1), IKBKB(2), IRF1(1), IRF3(1), IRF4(2), IRF6(5), JUN(3), LTA(2), MAP3K1(2), MAPK10(1), MDM2(1), MYC(1), NFKB1(2), NFKBIB(1), PRF1(1), RELA(2), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TP53(115), TRADD(1), TRAF1(4), TRAF3(1)	15688386	183	127	148	27	33	36	34	23	57	0	7.11e-15	2.08e-13
20	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(1), APAF1(1), ATM(6), BAX(1), BCL2L1(1), CASP7(2), CASP9(2), PRKCA(4), PTK2(4), PXN(3), STAT1(2), TLN1(3), TP53(115)	7458200	145	118	111	13	29	29	26	17	44	0	7.22e-15	2.08e-13
21	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), CDKN2A(22), CFL1(2), E2F1(2), MDM2(1), PRB1(2), TP53(115)	2182280	145	122	108	9	22	30	26	14	53	0	7.66e-15	2.08e-13
22	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(1), ATM(6), BAX(1), E2F1(2), GADD45A(1), MDM2(1), RB1(7), TP53(115)	4951604	134	118	100	5	23	27	21	15	48	0	7.66e-15	2.08e-13
23	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(6), CDC25B(1), CDC25C(1), CHEK1(4), RB1(7), TP53(115), WEE1(2)	4759720	136	119	102	5	24	28	21	14	49	0	7.77e-15	2.08e-13
24	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(2), MAP3K14(1), NFKB1(2), RELA(2), TP53(115)	2739598	122	113	88	4	21	21	21	14	45	0	8.55e-15	2.19e-13
25	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(1), EGFR(6), MYC(1), POLR2A(1), PRKCA(4), RB1(7), TEP1(3), TERF1(2), TERT(3), TNKS(7), TP53(115), XRCC5(1)	7681590	151	123	116	11	27	32	25	16	51	0	9.77e-15	2.41e-13
26	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(1), FOS(1), JUN(3), KEAP1(17), MAPK1(1), MAPK14(1), MAPK8(2), NFE2L2(21), PRKCA(4)	2383598	51	48	40	2	14	12	18	3	4	0	5.51e-14	1.30e-12
27	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(3), ACVR1C(3), AKT1(1), AKT3(2), ARRB1(2), ATF2(2), BDNF(1), BRAF(7), CACNA1A(7), CACNA1B(1), CACNA1C(12), CACNA1D(3), CACNA1E(14), CACNA1F(8), CACNA1G(5), CACNA1H(5), CACNA1I(8), CACNA1S(5), CACNA2D1(8), CACNA2D2(3), CACNA2D3(1), CACNA2D4(6), CACNB2(2), CACNB3(2), CACNB4(1), CACNG3(2), CACNG4(2), CACNG6(1), CACNG7(4), CD14(1), CDC25B(1), CDC42(1), CHP(2), CHUK(2), DAXX(2), DUSP10(3), DUSP16(1), DUSP4(2), DUSP5(4), DUSP6(1), DUSP7(1), DUSP9(2), EGF(6), EGFR(6), FAS(1), FASLG(1), FGF10(2), FGF12(3), FGF14(1), FGF2(2), FGF23(1), FGF3(1), FGF5(2), FGF6(2), FGF8(1), FGFR1(1), FGFR2(3), FGFR3(2), FGFR4(1), FLNA(8), FLNB(3), FLNC(11), FOS(1), GADD45A(1), GADD45G(1), GNA12(1), GNG12(1), HRAS(1), IKBKB(2), IL1B(1), IL1R2(3), JUN(3), KRAS(1), MAP2K1(2), MAP2K3(2), MAP2K5(1), MAP2K6(2), MAP3K1(2), MAP3K12(3), MAP3K13(5), MAP3K14(1), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K7(2), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(5), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MAPKAPK2(1), MAPKAPK5(3), MAPT(4), MEF2C(3), MKNK2(1), MOS(4), MRAS(2), MYC(1), NF1(20), NFATC2(4), NFATC4(1), NFKB1(2), NFKB2(2), NLK(2), NR4A1(4), NTF3(3), NTRK1(3), NTRK2(1), PAK1(1), PDGFB(1), PDGFRA(8), PDGFRB(4), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(5), PPM1A(2), PPM1B(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), PTPN5(1), PTPRR(7), RAC1(1), RAF1(1), RAP1B(1), RAPGEF2(5), RASA1(5), RASA2(3), RASGRF1(5), RASGRF2(4), RASGRP1(1), RASGRP3(6), RASGRP4(4), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KA6(4), RRAS2(2), SOS1(6), SOS2(5), SRF(2), STK3(2), STK4(2), TAOK1(6), TAOK2(5), TAOK3(3), TGFB1(1), TGFB2(2), TGFBR2(3), TNFRSF1A(2), TP53(115), TRAF6(1)	79663722	615	171	576	141	129	194	115	61	116	0	4.80e-13	1.09e-11
28	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(9), APC2(2), CAMK2B(2), CAMK2D(1), CCND2(3), CCND3(1), CHD8(8), CHP(2), CREBBP(12), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(2), CTBP1(1), CTNNB1(3), CUL1(2), DAAM1(1), DAAM2(5), DKK1(3), DKK2(1), DVL1(3), DVL3(2), EP300(6), FZD1(1), FZD10(1), FZD3(4), FZD4(1), FZD6(2), FZD7(1), FZD9(2), JUN(3), LEF1(3), LRP5(6), LRP6(3), MAP3K7(2), MAPK10(1), MAPK8(2), MAPK9(1), MYC(1), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NKD1(1), NKD2(2), NLK(2), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PORCN(2), PPARD(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRICKLE1(5), PRICKLE2(1), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), PSEN1(1), RAC1(1), RBX1(1), ROCK1(5), ROCK2(3), RUVBL1(2), SENP2(3), SFRP1(1), SFRP4(3), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(1), SMAD4(2), TBL1XR1(2), TBL1Y(2), TCF7(1), TP53(115), VANGL1(1), VANGL2(1), WIF1(3), WNT10B(2), WNT11(1), WNT2(3), WNT2B(2), WNT3(2), WNT3A(1), WNT6(2), WNT7A(2), WNT7B(1), WNT9A(1), WNT9B(1)	44570488	358	155	322	83	87	101	61	39	70	0	2.31e-11	5.08e-10
29	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	237	ADCYAP1R1(7), ADORA1(3), ADORA2A(5), ADRA1A(2), ADRA1B(3), ADRA2B(4), ADRA2C(2), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(1), C5AR1(1), CALCR(5), CALCRL(3), CCKAR(2), CCKBR(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), CNR1(2), CNR2(2), CRHR1(2), CRHR2(2), CTSG(3), CYSLTR1(2), CYSLTR2(1), DRD1(1), DRD2(2), DRD3(5), DRD4(1), DRD5(3), EDNRA(1), EDNRB(3), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), FSHB(1), FSHR(11), GABBR1(1), GABBR2(2), GABRA1(6), GABRA2(8), GABRA3(4), GABRA4(3), GABRA5(4), GABRA6(7), GABRB1(3), GABRB2(5), GABRB3(10), GABRD(2), GABRE(4), GABRG1(10), GABRG2(4), GABRG3(8), GABRP(1), GABRQ(5), GABRR1(2), GABRR2(2), GALR1(3), GH2(2), GHR(2), GHRHR(3), GHSR(2), GLP1R(1), GLP2R(3), GLRA1(2), GLRA2(4), GLRA3(3), GLRB(3), GPR156(1), GPR35(1), GPR50(4), GPR63(2), GPR83(2), GRIA1(6), GRIA2(3), GRIA3(8), GRIA4(7), GRID1(10), GRID2(12), GRIK1(4), GRIK2(8), GRIK3(7), GRIK4(3), GRIK5(1), GRIN1(1), GRIN2A(13), GRIN2B(15), GRIN2C(2), GRIN2D(2), GRIN3A(7), GRIN3B(4), GRM1(10), GRM2(2), GRM3(12), GRM4(1), GRM5(11), GRM6(4), GRM7(8), GRM8(8), GRPR(2), GZMA(4), HCRTR2(3), HRH1(3), HRH2(1), HRH3(1), HRH4(3), HTR1A(5), HTR1B(3), HTR1E(4), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(3), HTR5A(3), HTR6(1), HTR7(3), LEPR(10), LHB(1), LHCGR(7), LTB4R2(1), MAS1(3), MC2R(2), MC3R(2), MC4R(1), MC5R(3), MCHR1(2), MCHR2(3), MTNR1A(1), MTNR1B(9), NMBR(2), NMUR2(1), NPBWR1(1), NPFFR2(7), NPY1R(3), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(2), OPRD1(1), OPRM1(2), OXTR(1), P2RX2(1), P2RX3(4), P2RX4(1), P2RX7(1), P2RY1(2), P2RY10(2), P2RY13(1), P2RY14(3), P2RY2(1), P2RY4(1), P2RY6(1), PARD3(5), PPYR1(3), PRL(1), PRLHR(1), PRLR(5), PRSS1(3), PRSS3(2), PTAFR(3), PTGDR(5), PTGER2(2), PTGER3(5), PTGER4(2), PTGFR(2), PTGIR(1), PTH2R(3), RXFP1(7), SSTR1(1), SSTR2(2), SSTR3(1), SSTR4(2), SSTR5(1), TAAR1(4), TAAR2(2), TAAR5(5), TAAR6(4), TAAR8(2), TAAR9(2), TACR1(2), TACR3(3), TBXA2R(2), THRA(1), THRB(1), TRHR(1), TRPV1(2), TSHR(1)	60667562	641	165	639	205	173	222	137	39	70	0	4.11e-10	8.73e-09
30	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTN2(6), ACTN3(2), ACTN4(4), DES(2), DMD(21), FAM48A(1), MYBPC1(8), MYBPC3(3), MYH3(4), MYH6(11), MYH7(8), MYH8(20), MYL1(3), MYL2(1), MYL3(2), MYOM1(9), NEB(20), TNNI2(1), TNNI3(1), TNNT1(1), TNNT2(2), TNNT3(3), TPM3(1), TTN(249), VIM(4)	37572952	388	142	386	128	104	115	98	28	37	6	3.09e-09	6.31e-08
31	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(1), AKT3(2), BTK(4), CDKN2A(22), GSK3A(3), IARS(3), INPP5D(5), PDK1(1), PIK3CA(20), PPP1R13B(4), PTEN(13), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(1), SOS1(6), SOS2(5), TEC(2), YWHAB(1), YWHAQ(1)	9741584	104	77	90	10	22	23	26	4	29	0	3.18e-09	6.31e-08
32	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(4), CYP11A1(2), CYP11B1(11), CYP11B2(6), CYP17A1(1), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(3)	2426318	38	35	38	3	8	16	6	6	2	0	8.97e-08	1.67e-06
33	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(4), CYP11A1(2), CYP11B1(11), CYP11B2(6), CYP17A1(1), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(3)	2426318	38	35	38	3	8	16	6	6	2	0	8.97e-08	1.67e-06
34	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), AKT3(2), BCR(1), BTK(4), CD19(2), CDKN2A(22), FLOT1(1), GAB1(2), ITPR1(4), ITPR2(11), ITPR3(1), LYN(1), NR0B2(1), PDK1(1), PHF11(1), PIK3CA(20), PITX2(3), PLCG2(3), PPP1R13B(4), PREX1(12), PTEN(13), PTPRC(3), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KB1(1), SYK(1), TEC(2), VAV1(7)	15074642	130	92	116	28	32	34	26	8	30	0	1.50e-07	2.72e-06
35	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(1), COL11A1(31), COL11A2(10), COL17A1(4), COL1A1(8), COL1A2(12), COL2A1(8), COL3A1(10), COL4A1(6), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(5), COL5A2(11), COL5A3(11), COL6A3(10), COL6A6(19), COMP(1), DES(2), DSC1(5), DSC2(1), DSC3(6), DSG1(8), DSG2(2), DSG3(3), DSG4(5), FN1(16), GJA1(4), GJA10(5), GJA8(3), GJA9(1), GJB2(1), GJB4(1), GJC1(2), GJC2(1), GJC3(1), GJD2(2), GJD4(2), IBSP(4), INA(2), ITGA6(3), ITGB4(6), KRT1(1), KRT10(1), KRT12(3), KRT13(2), KRT14(1), KRT16(3), KRT17(2), KRT18(2), KRT2(4), KRT20(2), KRT23(2), KRT24(3), KRT27(2), KRT28(1), KRT3(2), KRT31(1), KRT32(2), KRT33A(1), KRT35(1), KRT36(2), KRT37(2), KRT4(1), KRT5(1), KRT6A(1), KRT6B(2), KRT71(2), KRT72(2), KRT73(6), KRT75(1), KRT76(2), KRT77(3), KRT79(3), KRT81(3), KRT82(1), KRT84(1), KRT85(1), KRT9(1), LAMA1(12), LAMA2(18), LAMA3(7), LAMA4(13), LAMA5(6), LAMB1(5), LAMB2(2), LAMB3(1), LAMB4(3), LAMC1(8), LAMC2(2), LAMC3(1), NES(11), PRPH(2), RELN(24), THBS1(1), THBS2(12), THBS3(3), THBS4(1), TNC(11), TNN(14), TNR(16), TNXB(15), VIM(4), VWF(15)	67804472	532	160	531	151	136	189	118	33	56	0	7.29e-07	0.000013
36	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(1), BDKRB2(2), CHRNA1(1), FLT1(8), FLT4(3), KDR(12), NOS3(1), PDE2A(2), PDE3A(4), PDE3B(3), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKG1(4), PRKG2(3), RYR2(84), SLC7A1(4), SYT1(3)	11156150	144	81	142	47	40	46	27	13	18	0	9.92e-07	0.000017
37	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(6), GABRA2(8), GABRA3(4), GABRA4(3), GABRA5(4), GABRA6(7), PRKCE(3)	2131728	35	31	35	6	10	11	8	1	5	0	1.16e-06	0.000019
38	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(1), AKT3(2), BCL2L1(1), CDC42(1), CDKN2A(22), CREB1(1), CREB3(2), CREB5(3), ERBB4(9), F2RL2(1), GAB1(2), GADD45A(1), GSK3A(3), IGF1(3), INPPL1(3), IRS1(3), IRS2(2), IRS4(2), MET(3), MYC(1), NOLC1(2), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PARD3(5), PARD6A(1), PDK1(1), PIK3CA(20), PIK3CD(3), PPP1R13B(4), PREX1(12), PTEN(13), PTK2(4), PTPN1(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(1), SLC2A4(2), SOS1(6), SOS2(5), TSC1(5), TSC2(5), YWHAB(1), YWHAQ(1)	20981038	174	107	160	35	38	50	41	10	35	0	1.20e-06	0.000020
39	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADORA1(3), ADORA2A(5), ADRA1A(2), ADRA1B(3), ADRA1D(2), ADRA2C(2), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(1), CCBP2(3), CCKAR(2), CCKBR(1), CCR1(2), CCR10(1), CCR3(1), CCR4(3), CCR6(2), CCR8(1), CCRL1(2), CCRL2(1), CHML(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), CNR1(2), CNR2(2), CX3CR1(3), CXCR3(1), CXCR4(5), DRD1(1), DRD2(2), DRD3(5), DRD4(1), DRD5(3), EDNRA(1), EDNRB(3), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), FSHR(11), GALR1(3), GALT(1), GHSR(2), GPR17(3), GPR174(4), GPR27(1), GPR35(1), GPR37(2), GPR37L1(2), GPR50(4), GPR6(2), GPR63(2), GPR77(3), GPR83(2), GPR85(2), GPR87(4), GRPR(2), HCRTR2(3), HRH1(3), HRH2(1), HRH3(1), HTR1A(5), HTR1B(3), HTR1E(4), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(3), HTR5A(3), HTR6(1), HTR7(3), LHCGR(7), MAS1(3), MC3R(2), MC4R(1), MC5R(3), MTNR1A(1), MTNR1B(9), NMBR(2), NMUR2(1), NPY1R(3), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(2), OPN1SW(1), OPN3(1), OPRD1(1), OPRM1(2), OR10A5(1), OR11A1(3), OR12D3(4), OR1F1(1), OR1Q1(2), OR2H1(1), OR5V1(1), OR8B8(5), OXTR(1), P2RY1(2), P2RY10(2), P2RY13(1), P2RY14(3), P2RY2(1), P2RY6(1), PPYR1(3), PTAFR(3), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), RGR(1), RHO(1), SSTR1(1), SSTR2(2), SSTR3(1), SSTR4(2), SUCNR1(2), TBXA2R(2), TRHR(1)	32937654	298	137	298	101	74	108	65	16	35	0	8.18e-06	0.00013
40	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(8), GABBR1(1), GPRC5A(1), GPRC5C(4), GRM1(10), GRM2(2), GRM3(12), GRM4(1), GRM5(11), GRM7(8), GRM8(8)	5627292	66	51	66	29	14	20	15	8	9	0	0.000012	0.00019
41	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(7), ADCY2(14), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), ADRA1A(2), ADRA1B(3), ADRA1D(2), ADRB2(3), ANXA6(4), ARRB1(2), ATP1A4(3), ATP1B2(1), ATP2A2(3), ATP2A3(2), ATP2B1(3), ATP2B2(5), ATP2B3(2), CACNA1A(7), CACNA1B(1), CACNA1C(12), CACNA1D(3), CACNA1E(14), CACNA1S(5), CACNB3(2), CALR(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CASQ1(1), CASQ2(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), GJA1(4), GJB2(1), GJB4(1), GNAI3(1), GNAZ(2), GNB1(1), GNB2(2), GNB4(2), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK6(1), ITPR1(4), ITPR2(11), ITPR3(1), KCNB1(1), KCNJ3(7), KCNJ5(2), MIB1(2), NME7(2), PEA15(1), PLCB3(3), PLN(1), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCQ(4), PRKD1(9), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS20(1), RGS3(4), RGS5(1), RGS6(4), RGS7(8), RGS9(2), RYR1(24), RYR2(84), RYR3(38), SFN(2), SLC8A1(11), SLC8A3(3), USP5(1), YWHAB(1), YWHAQ(1)	51879168	437	146	434	125	116	160	81	33	47	0	0.000016	0.00024
42	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(3), CPS1(18), GLS(2), GLUD1(4)	2011222	29	28	28	5	9	9	6	1	4	0	0.000017	0.00025
43	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), BCAR1(5), ILK(1), ITGB1(3), MAPK1(1), MAPK3(1), PDK2(1), PDPK1(1), PIK3CA(20), PIK3R1(1), PTEN(13), PTK2(4), SHC1(1), SOS1(6)	5299772	59	49	48	6	23	11	14	3	8	0	0.000021	0.00030
44	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNE2(2), CDKN2A(22), E2F1(2), PRB1(2)	2352092	28	27	25	2	2	10	5	0	11	0	0.000029	0.00040
45	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(1), ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), AKT1(1), AKT3(2), AMOTL1(3), ASH1L(7), CASK(1), CDC42(1), CGN(4), CLDN1(2), CLDN10(4), CLDN16(4), CLDN17(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN6(1), CLDN8(1), CLDN9(3), CSDA(2), CSNK2A1(2), CTNNA2(17), CTNNA3(10), CTNNB1(3), CTTN(2), EPB41(2), EPB41L1(1), EPB41L2(1), EPB41L3(11), EXOC3(2), EXOC4(2), F11R(1), GNAI1(2), GNAI3(1), HCLS1(3), HRAS(1), IGSF5(2), INADL(9), KRAS(1), LLGL1(1), LLGL2(2), MAGI1(5), MAGI2(7), MAGI3(1), MLLT4(1), MPDZ(4), MPP5(2), MRAS(2), MYH1(13), MYH10(1), MYH11(7), MYH13(8), MYH14(4), MYH15(10), MYH2(21), MYH3(4), MYH4(14), MYH6(11), MYH7(8), MYH7B(4), MYH8(20), MYH9(12), MYL2(1), MYLPF(1), PARD3(5), PARD6A(1), PPM1J(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(2), PPP2R4(1), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCI(4), PRKCQ(4), PTEN(13), RAB3B(1), RRAS2(2), SPTAN1(2), SYMPK(6), TJAP1(4), TJP1(8), TJP2(3), TJP3(1), VAPA(1), YES1(1)	52815626	380	152	380	111	96	113	74	41	56	0	0.000044	0.00061
46	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ADCY1(7), ADCY2(14), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), ARRB1(2), ATF2(2), ATP2A2(3), ATP2A3(2), CACNB3(2), CAMK2B(2), CAMK2D(1), CNN1(2), CORIN(8), CREB3(2), CRHR1(2), DGKZ(3), FOS(1), GABPA(2), GABPB2(1), GJA1(4), GNB1(1), GNB2(2), GNB4(2), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK6(1), GSTO1(1), GUCY1A3(5), IGFBP3(1), IGFBP6(1), IL1B(1), ITPR1(4), ITPR2(11), ITPR3(1), JUN(3), MIB1(2), MYL2(1), MYLK2(2), NFKB1(2), NOS1(10), NOS3(1), OXTR(1), PDE4B(3), PDE4D(1), PLCB3(3), PLCG1(1), PLCG2(3), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCQ(4), PRKD1(9), RAMP2(1), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS20(1), RGS3(4), RGS5(1), RGS6(4), RGS7(8), RGS9(2), RYR1(24), RYR2(84), RYR3(38), SFN(2), SLC8A1(11), SP1(1), TNXB(15), USP5(1), YWHAB(1), YWHAQ(1)	47658432	396	143	392	114	113	140	75	25	43	0	0.000050	0.00066
47	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNB1(1), CCND2(3), CCND3(1), CDK7(1), CDKN2A(22), CDKN2C(1), E2F1(2), RB1(7), RBL1(5)	4296030	43	37	40	4	3	11	9	3	17	0	0.000058	0.00076
48	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A1(4), EIF4A2(2), EIF4B(4), EIF4G1(6), EIF4G2(2), EIF4G3(3), PDK2(1), PDPK1(1), PIK3CA(20), PIK3R1(1), PTEN(13), RPS6(1), RPS6KB1(1), TSC1(5), TSC2(5)	7493622	70	57	59	10	18	18	16	5	13	0	0.00012	0.0015
49	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), AKT3(2), BPNT1(1), ILK(1), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(20), PIK3CD(3), PTEN(13), RBL2(5), SHC1(1), SOS1(6)	5509812	56	48	45	6	19	11	14	4	8	0	0.00022	0.0027
50	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(20), PIK3R1(1), PLCB1(6), PLCG1(1), PRKCA(4), VAV1(7)	3448216	40	37	29	6	20	8	7	4	1	0	0.00036	0.0044
51	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(1), AKT3(2), BRD4(2), CAP1(2), CBL(1), CDC42(1), CDKN2A(22), F2RL2(1), FLOT1(1), GSK3A(3), INPPL1(3), IRS1(3), IRS2(2), IRS4(2), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(5), PARD6A(1), PDK1(1), PIK3CA(20), PIK3CD(3), PIK3R1(1), PPYR1(3), PTEN(13), PTPN1(1), RAF1(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KB1(1), SERPINB6(4), SFN(2), SHC1(1), SLC2A4(2), SORBS1(5), SOS1(6), SOS2(5), YWHAB(1), YWHAQ(1)	16118968	133	86	119	21	29	35	32	8	29	0	0.00038	0.0046
52	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A1(4), EIF4A2(2), EIF4G1(6), EIF4G2(2), EIF4G3(3), GHR(2), IRS1(3), MAPK1(1), MAPK14(1), MAPK3(1), PABPC1(2), PDK2(1), PDPK1(1), PIK3CA(20), PIK3R1(1), PRKCA(4), PTEN(13), RPS6KB1(1)	7576570	69	58	58	13	20	19	16	5	9	0	0.00050	0.0060
53	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), GBA3(6), LPO(2), MPO(3), PRDX1(1), PRDX6(1), TPO(10), TYR(3)	2635646	30	27	30	7	4	11	12	1	2	0	0.00079	0.0090
54	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(6), GABRA2(8), GABRA3(4), GABRA4(3), GABRA5(4), GABRA6(7), GPHN(1), NSF(2), UBQLN1(1)	3229276	37	31	37	8	8	14	9	1	5	0	0.00079	0.0090
55	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(3), F11(3), F12(1), F13B(7), F5(14), F8(9), F9(4), FGA(5), FGB(3), FGG(1), LPA(11), PLAT(1), PLAU(2), PLG(1), SERPINB2(3), SERPINF2(3), VWF(15)	9480458	86	64	86	19	15	32	24	7	8	0	0.00084	0.0094
56	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(7), ADCY8(13), ARAF(3), BRAF(7), CACNA1C(12), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CHP(2), CREBBP(12), EP300(6), GRIA1(6), GRIA2(3), GRIN1(1), GRIN2A(13), GRIN2B(15), GRIN2C(2), GRIN2D(2), GRM1(10), GRM5(11), HRAS(1), ITPR1(4), ITPR2(11), ITPR3(1), KRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), RAF1(1), RAP1B(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA6(4)	27622752	212	117	210	66	64	62	36	26	24	0	0.00086	0.0094
57	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(1), APC(9), CD14(1), CTNNB1(3), DVL1(3), FZD1(1), GJA1(4), GNAI1(2), IRAK1(3), LBP(4), LEF1(3), NFKB1(2), PDPK1(1), PIK3CA(20), PIK3R1(1), RELA(2), TLR4(10), TOLLIP(1)	8223600	71	58	60	13	22	16	18	7	8	0	0.00087	0.0094
58	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(3), AGT(1), AGTR1(2), AGTR2(3), ANPEP(5), CMA1(2), CPA3(4), CTSA(2), CTSG(3), ENPEP(7), LNPEP(2), MAS1(3), MME(8), NLN(2), THOP1(1)	5741924	52	46	52	14	10	21	8	4	9	0	0.0012	0.012
59	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(7), CREM(2), FSHB(1), FSHR(11), GNAS(5), XPO1(2)	2597732	28	26	28	11	7	8	6	5	2	0	0.0014	0.014
60	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(5), CD2(1), CD33(2), CD5(2), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12A(1), IL12B(2), IL4(2), ITGAX(9), TLR2(3), TLR4(10), TLR7(3), TLR9(1)	5001444	45	40	44	14	9	17	9	4	6	0	0.0017	0.017
61	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), EIF2B5(1), IGF1(3), INPPL1(3), PDK2(1), PDPK1(1), PIK3CA(20), PIK3R1(1), PTEN(13), RPS6(1), RPS6KB1(1)	5349790	46	42	35	8	15	8	9	4	10	0	0.0023	0.023
62	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(1), AKT3(2), BLNK(1), BTK(4), CARD11(3), CD19(2), CD22(5), CD81(1), CHP(2), CHUK(2), CR2(9), FCGR2B(2), FOS(1), HRAS(1), IKBKB(2), INPP5D(5), JUN(3), KRAS(1), LILRB3(3), LYN(1), MALT1(1), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB1(2), NFKB2(2), NFKBIB(1), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG2(3), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), RAC1(1), RASGRP3(6), SYK(1), VAV1(7), VAV2(3), VAV3(1)	20264588	142	93	130	37	43	34	22	20	23	0	0.0023	0.023
63	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(2), ASL(3), CKB(1), CKM(2), CKMT2(1), CPS1(18), DAO(1), EPRS(10), GATM(1), GLUD1(4), GLUD2(7), GOT2(2), LAP3(1), NOS1(10), NOS3(1), OTC(2), P4HA1(2), P4HA2(2), P4HA3(3), PARS2(2), RARS(4), RARS2(2)	9714172	84	63	83	17	20	28	17	5	14	0	0.0025	0.024
64	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA1B(3), ADRA1D(2), ADRA2C(2), ADRB2(3), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), DRD1(1), DRD2(2), DRD3(5), DRD4(1), DRD5(3), HRH1(3), HRH2(1), HTR1A(5), HTR1B(3), HTR1E(4), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(3), HTR5A(3), HTR6(1), HTR7(3)	7002876	69	51	69	27	15	25	22	3	4	0	0.0026	0.025
65	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(7), CALCR(5), CALCRL(3), CRHR1(2), CRHR2(2), ELTD1(16), EMR1(9), EMR2(4), GHRHR(3), GLP1R(1), GLP2R(3), GPR64(3), LPHN1(1), LPHN2(6), LPHN3(13)	7428118	78	52	78	22	20	25	15	7	11	0	0.0026	0.025
66	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN1(1), GRIN2A(13), GRIN2B(15), GRIN2C(2), GRIN2D(2), NOS1(10), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), SYT1(3)	6877564	67	51	66	18	23	19	6	10	9	0	0.0026	0.025
67	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(2), AGTR2(3), ATP8A1(5), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(1), CCKAR(2), CCKBR(1), CCR1(2), CCR10(1), CCR3(1), CCR4(3), CCR6(2), CCR8(1), CX3CR1(3), CXCR3(1), CXCR4(5), EDNRA(1), EDNRB(3), FPR1(1), FSHR(11), GALR1(3), GALT(1), GHSR(2), GPR77(3), GRPR(2), LHCGR(7), MC2R(2), MC3R(2), MC4R(1), MC5R(3), NMBR(2), NPY1R(3), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(2), OPRD1(1), OPRM1(2), OXTR(1), PPYR1(3), SSTR1(1), SSTR2(2), SSTR3(1), SSTR4(2), TACR1(2), TACR3(3), TRHR(1), TSHR(1)	13849112	118	75	118	42	27	42	23	6	20	0	0.0031	0.028
68	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(7), AKT1(1), CAMK2B(2), CAMK2D(1), CREB1(1), GNAS(5), HRAS(1), MAPK1(1), MAPK14(1), MAPK3(1), PIK3CA(20), PIK3R1(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), RAC1(1), RPS6KA1(2), RPS6KA5(4), SOS1(6)	7817404	67	55	56	11	24	14	18	6	5	0	0.0037	0.033
69	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT3(2), BTK(4), FCER1A(2), FYN(3), HRAS(1), IL4(2), INPP5D(5), KRAS(1), LCP2(2), LYN(1), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), MS4A2(3), PDK1(1), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(5), PLCG1(1), PLCG2(3), PRKCA(4), PRKCD(2), PRKCE(3), RAC1(1), RAF1(1), SOS1(6), SOS2(5), SYK(1), VAV1(7), VAV2(3), VAV3(1)	19629306	142	94	131	31	42	41	27	13	19	0	0.0044	0.039
70	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA3(6), LPO(2), MPO(3), PRDX6(1), TPO(10)	2302786	26	23	26	6	4	9	11	1	1	0	0.0044	0.039
71	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	CNR1(2), CNR2(2), DNMT1(3), MTNR1A(1), MTNR1B(9), PTAFR(3), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), TBXA2R(2)	3166976	34	30	34	8	11	16	6	0	1	0	0.0046	0.039
72	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(4), ARSB(1), ARSD(1), ARSE(2), CYP11B1(11), CYP11B2(6), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(3), SRD5A1(2), SRD5A2(2), STS(3), SULT1E1(1), SULT2A1(3), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2B15(1), UGT2B4(4)	7061616	64	50	64	8	14	22	15	7	6	0	0.0048	0.041
73	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(2), ADC(1), ALDH4A1(3), ALDH5A1(1), CAD(8), CPS1(18), EARS2(2), EPRS(10), GAD1(4), GAD2(5), GCLC(2), GCLM(1), GFPT2(1), GLS(2), GLUD1(4), GLUD2(7), GLUL(2), GOT2(2), GPT(1), GPT2(2), GSR(2), GSS(2), NADSYN1(6), PPAT(2)	10615030	90	66	89	21	20	34	19	9	8	0	0.0051	0.043
74	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CUL1(2), E2F1(2), FBXW7(10), RB1(7)	2297980	21	21	19	3	1	8	2	1	9	0	0.0056	0.046
75	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), AKT3(2), BRAF(7), CAB39(1), DDIT4(2), EIF4B(4), FIGF(1), HIF1A(1), IGF1(3), MAPK1(1), MAPK3(1), PDPK1(1), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PRKAA2(3), RICTOR(3), RPS6(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA6(4), RPS6KB1(1), STK11(3), TSC1(5), TSC2(5), ULK1(1), ULK2(2), VEGFC(4)	14641212	105	79	93	24	28	28	26	8	15	0	0.0057	0.047
76	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3D(1), CD80(2), CD86(1), HLA-DRA(1), HLA-DRB1(1), ICOS(2), ITK(2), LCK(2), PIK3CA(20), PIK3R1(1), PTPN11(2)	3418312	35	31	24	8	15	9	7	2	2	0	0.0059	0.048
77	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(2), ALDH4A1(3), ALDH5A1(1), CAD(8), CPS1(18), EPRS(10), GAD1(4), GAD2(5), GCLC(2), GCLM(1), GLS(2), GLUD1(4), GLUL(2), GOT2(2), GPT(1), GPT2(2), GSS(2), NADSYN1(6), PPAT(2)	8890922	77	59	76	16	18	30	18	5	6	0	0.0061	0.048
78	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(2), FOS(1), HRAS(1), INSR(7), IRS1(3), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PIK3CA(20), PIK3R1(1), PTPN11(2), RAF1(1), RASA1(5), SHC1(1), SLC2A4(2), SOS1(6), SRF(2)	6881836	62	51	50	8	23	16	12	5	6	0	0.0061	0.048
79	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	ARAF(3), BRAF(7), CD244(2), CHP(2), FAS(1), FASLG(1), FCGR3A(3), FCGR3B(2), FYN(3), GZMB(1), HLA-A(7), HLA-B(1), HLA-C(1), HLA-G(1), HRAS(1), ICAM1(2), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), ITGAL(1), ITGB2(3), KIR2DL1(1), KIR2DL3(4), KIR3DL1(6), KIR3DL2(1), KLRC1(1), KLRC3(1), KRAS(1), LCK(2), LCP2(2), MAP2K1(2), MAPK1(1), MAPK3(1), NCR1(5), NCR2(1), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), PAK1(1), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRF1(1), PRKCA(4), PRKCG(8), PTPN11(2), RAC1(1), RAF1(1), SH2D1A(1), SHC1(1), SHC2(2), SHC3(2), SHC4(4), SOS1(6), SOS2(5), SYK(1), TNFRSF10A(1), TNFRSF10B(1), TYROBP(3), ULBP1(1), ULBP3(1), VAV1(7), VAV2(3), VAV3(1), ZAP70(2)	30808240	218	113	206	57	58	64	47	22	25	2	0.0062	0.048
80	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(7), AKT1(1), BAX(1), BCL2L1(1), CSF2RB(5), IGF1(3), KIT(5), PIK3CA(20), PIK3R1(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	5621418	52	45	41	7	22	16	8	3	3	0	0.0062	0.048
81	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(7), ADCY2(14), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), DRD1(1), DRD2(2), EGF(6), EGFR(6), GJA1(4), GJD2(2), GNAI1(2), GNAI3(1), GNAS(5), GRM1(10), GRM5(11), GUCY1A2(10), GUCY1A3(5), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(4), HRAS(1), HTR2A(1), HTR2B(1), HTR2C(2), ITPR1(4), ITPR2(11), ITPR3(1), KRAS(1), MAP2K1(2), MAP2K5(1), MAPK1(1), MAPK3(1), MAPK7(1), NPR1(2), NPR2(2), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(4), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKG1(4), PRKG2(3), PRKX(1), RAF1(1), SOS1(6), SOS2(5), TJP1(8), TUBA1B(1), TUBA3C(5), TUBA3D(2), TUBA3E(3), TUBA8(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(2), TUBB4(4), TUBB4Q(1), TUBB8(1)	36050340	258	125	257	68	71	76	49	30	32	0	0.0064	0.048
82	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), DOCK1(3), FOS(1), GAB1(2), HGF(6), HRAS(1), ITGA1(3), ITGB1(3), JUN(3), MAP2K1(2), MAP4K1(2), MAPK1(1), MAPK3(1), MAPK8(2), MET(3), PAK1(1), PIK3CA(20), PIK3R1(1), PTEN(13), PTK2(4), PTPN11(2), PXN(3), RAF1(1), RAP1B(1), RASA1(5), SOS1(6), STAT3(1)	12099016	92	71	80	24	29	23	17	8	15	0	0.0069	0.052
83	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(2), CYP11B2(6), CYP17A1(1), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(3)	1860812	21	19	21	5	3	9	4	4	1	0	0.0070	0.052
84	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(1), ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), AKT1(1), AKT3(2), ARHGAP5(1), BCAR1(5), BIRC3(3), BRAF(7), CAPN2(2), CAV2(1), CAV3(1), CCND2(3), CCND3(1), CDC42(1), COL11A1(31), COL11A2(10), COL1A1(8), COL1A2(12), COL2A1(8), COL3A1(10), COL4A1(6), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(5), COL5A2(11), COL5A3(11), COL6A3(10), COL6A6(19), COMP(1), CTNNB1(3), DIAPH1(1), DOCK1(3), EGF(6), EGFR(6), ERBB2(1), FARP2(6), FIGF(1), FLNA(8), FLNB(3), FLNC(11), FLT1(8), FN1(16), FYN(3), GRLF1(11), HGF(6), HRAS(1), IBSP(4), IGF1(3), ILK(1), ITGA1(3), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGAV(3), ITGB1(3), ITGB3(3), ITGB4(6), ITGB6(1), ITGB7(1), ITGB8(3), JUN(3), KDR(12), LAMA1(12), LAMA2(18), LAMA3(7), LAMA4(13), LAMA5(6), LAMB1(5), LAMB2(2), LAMB3(1), LAMB4(3), LAMC1(8), LAMC2(2), LAMC3(1), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MET(3), MYL2(1), MYLK(5), MYLK2(2), MYLPF(1), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PARVB(1), PARVG(1), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(4), PDPK1(1), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP5K1C(1), PRKCA(4), PRKCG(8), PTEN(13), PTK2(4), PXN(3), RAC1(1), RAF1(1), RAP1B(1), RAPGEF1(3), RELN(24), ROCK1(5), ROCK2(3), SHC1(1), SHC2(2), SHC3(2), SHC4(4), SOS1(6), SOS2(5), THBS1(1), THBS2(12), THBS3(3), THBS4(1), TLN1(3), TLN2(11), TNC(11), TNN(14), TNR(16), TNXB(15), VASP(2), VAV1(7), VAV2(3), VAV3(1), VCL(2), VEGFC(4), VWF(15)	101666124	755	167	741	217	196	257	155	56	91	0	0.0080	0.059
85	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(1), AGT(1), AKT1(1), CALR(1), CAMK1G(2), CAMK4(3), CREBBP(12), CSNK1A1(2), ELSPBP1(1), FGF2(2), HAND1(1), HAND2(1), HRAS(1), IGF1(3), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MEF2C(3), MYH2(21), NFATC2(4), NFATC3(2), NFATC4(1), NKX2-5(2), PIK3CA(20), PIK3R1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RAF1(1), RPS6KB1(1), SYT1(3)	13631774	114	77	103	29	38	32	18	15	11	0	0.0081	0.059
86	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLUD1(4), GLUD2(7)	1147388	13	13	13	3	3	4	1	2	3	0	0.0088	0.063
87	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(2), C1GALT1C1(1), GALNT1(1), GALNT10(1), GALNT11(2), GALNT12(3), GALNT13(10), GALNT14(3), GALNT2(2), GALNT3(2), GALNT5(6), GALNT6(2), GALNT8(2), GALNTL1(3), GALNTL4(3), GALNTL5(3), GCNT1(2), GCNT3(2), OGT(2), ST3GAL1(1), ST6GALNAC1(3), WBSCR17(9)	8702954	66	57	64	19	12	25	18	5	6	0	0.0096	0.068
88	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(10), SNCAIP(3), UBE2E2(1), UBE2G2(1), UBE2L6(1)	1721794	18	18	18	4	3	3	8	1	3	0	0.011	0.074
89	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(7), ITGB1(3), KLRC1(1), KLRC3(1), MAP2K1(2), MAPK3(1), PAK1(1), PIK3CA(20), PIK3R1(1), RAC1(1), SYK(1), VAV1(7)	5023516	47	38	36	7	19	7	10	5	4	2	0.012	0.081
90	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), HRAS(1), KLK2(1), NTRK1(3), PIK3CA(20), PIK3R1(1), PLCG1(1), PRKCA(4), SHC1(1), SOS1(6)	4212014	39	34	28	6	16	8	10	2	3	0	0.012	0.081
91	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1A(2), CDC42(1), PAK1(1), PDGFRA(8), PIK3CA(20), PIK3R1(1), RAC1(1), WASL(2)	3584742	36	32	25	4	18	7	8	3	0	0	0.012	0.083
92	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(2)	537204	8	8	8	3	3	1	3	0	1	0	0.013	0.089
93	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(1), EPHB1(13), FYN(3), ITGA1(3), ITGB1(3), L1CAM(2), LYN(1), RAP1B(1), SELP(8)	4224830	36	34	36	17	13	7	7	1	8	0	0.014	0.090
94	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), CREB1(1), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(2), PIK3CA(20), PIK3R1(1), RB1(7), RELA(2), SP1(1)	5286778	46	40	35	7	20	12	6	2	6	0	0.014	0.093
95	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(5), AMY2B(3), ENPP1(7), ENPP3(3), G6PC(2), GANAB(5), GBA3(6), GBE1(1), GCK(1), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(3), HK2(5), HK3(5), MGAM(3), PYGB(3), PYGM(4), SI(31), UGDH(2), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2B15(1), UGT2B4(4), UXS1(3)	15203514	120	78	120	26	30	44	28	8	10	0	0.015	0.098
96	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(4), ARSD(1), ARSE(2), CARM1(1), CYP11B1(11), CYP11B2(6), CYP19A1(4), HSD11B1(3), HSD11B2(1), HSD17B1(1), HSD17B12(1), HSD17B7(1), HSD3B1(4), HSD3B2(3), LCMT1(2), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), SRD5A1(2), SRD5A2(2), STS(3), SULT1E1(1), SULT2A1(3), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2), WBSCR22(3)	13001654	105	73	105	14	29	33	23	11	9	0	0.016	0.10
97	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(7), ADCY2(14), ADCY3(4), ADCY4(3), ADCY7(4), ADCY8(13), ADCY9(3), ADORA2A(5), ADRA1A(2), ADRA1B(3), ADRA1D(2), ADRB2(3), AGTR1(2), ATP2A1(1), ATP2A2(3), ATP2A3(2), ATP2B1(3), ATP2B2(5), ATP2B3(2), ATP2B4(3), AVPR1A(3), AVPR1B(2), BDKRB1(1), BDKRB2(2), BST1(1), CACNA1A(7), CACNA1B(1), CACNA1C(12), CACNA1D(3), CACNA1E(14), CACNA1F(8), CACNA1G(5), CACNA1H(5), CACNA1I(8), CACNA1S(5), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CCKAR(2), CCKBR(1), CD38(1), CHP(2), CHRM2(6), CHRM3(4), CHRM5(2), CYSLTR1(2), CYSLTR2(1), DRD1(1), EDNRA(1), EDNRB(3), EGFR(6), ERBB2(1), ERBB3(3), ERBB4(9), F2R(2), GNA14(1), GNAL(1), GNAS(5), GRIN1(1), GRIN2A(13), GRIN2C(2), GRIN2D(2), GRM1(10), GRM5(11), GRPR(2), HRH1(3), HRH2(1), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(3), HTR5A(3), HTR6(1), HTR7(3), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), LHCGR(7), LTB4R2(1), MYLK(5), MYLK2(2), NOS1(10), NOS3(1), NTSR1(3), OXTR(1), P2RX2(1), P2RX3(4), P2RX4(1), P2RX7(1), PDE1A(2), PDE1B(1), PDE1C(11), PDGFRA(8), PDGFRB(4), PHKA1(4), PHKA2(2), PHKB(6), PHKG1(2), PHKG2(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCD3(1), PLCE1(11), PLCG1(1), PLCG2(3), PLCZ1(4), PLN(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), PTAFR(3), PTGER3(5), PTGFR(2), RYR1(24), RYR2(84), RYR3(38), SLC8A1(11), SLC8A3(3), SPHK2(1), TACR1(2), TACR3(3), TBXA2R(2), TNNC1(1), TRHR(1), TRPC1(4), VDAC1(1)	74744692	632	160	628	177	183	211	114	57	67	0	0.018	0.11
98	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(3), CA12(2), CA13(1), CA14(1), CA3(2), CA4(1), CA5A(1), CA5B(2), CA6(2), CA7(1), CA9(1), CPS1(18), GLS(2), GLUD1(4), GLUD2(7), GLUL(2)	5640108	50	40	49	4	16	14	10	4	6	0	0.018	0.11
99	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(2), ABLIM1(2), ABLIM2(2), ABLIM3(1), ARHGEF12(3), CDC42(1), CDK5(1), CFL1(2), CFL2(1), CHP(2), CXCR4(5), DCC(12), DPYSL2(1), DPYSL5(6), EFNA3(1), EFNB1(2), EFNB2(1), EPHA1(3), EPHA2(1), EPHA3(6), EPHA4(1), EPHA5(15), EPHA6(9), EPHA7(7), EPHA8(4), EPHB1(13), EPHB2(4), EPHB3(6), EPHB4(2), EPHB6(3), FYN(3), GNAI1(2), GNAI3(1), HRAS(1), ITGB1(3), KRAS(1), L1CAM(2), LIMK2(2), LRRC4C(18), MAPK1(1), MAPK3(1), MET(3), NCK1(2), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NGEF(1), NRP1(5), NTN1(2), NTN4(1), NTNG1(1), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PLXNA1(6), PLXNA2(2), PLXNA3(3), PLXNB1(3), PLXNB3(3), PLXNC1(8), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PTK2(4), RAC1(1), RASA1(5), RGS3(4), ROBO1(6), ROBO2(6), ROBO3(4), ROCK1(5), ROCK2(3), SEMA3A(3), SEMA3B(1), SEMA3C(5), SEMA3D(2), SEMA3E(3), SEMA3F(3), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(2), SEMA4D(1), SEMA4F(5), SEMA5A(7), SEMA5B(4), SEMA6C(5), SEMA6D(6), SEMA7A(1), SLIT1(4), SLIT2(10), SLIT3(8), SRGAP1(2), SRGAP2(4), SRGAP3(3), UNC5B(2), UNC5C(6), UNC5D(12)	54208654	362	140	362	129	94	119	69	30	50	0	0.019	0.12
100	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	86	AGRN(1), CD36(1), CD44(3), CD47(2), COL11A1(31), COL11A2(10), COL1A1(8), COL1A2(12), COL2A1(8), COL3A1(10), COL4A1(6), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(5), COL5A2(11), COL5A3(11), COL6A3(10), COL6A6(19), DAG1(1), FN1(16), FNDC1(7), FNDC3A(1), GP1BA(2), GP5(3), GP6(2), GP9(1), HMMR(1), HSPG2(7), IBSP(4), ITGA1(3), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGAV(3), ITGB1(3), ITGB3(3), ITGB4(6), ITGB6(1), ITGB7(1), ITGB8(3), LAMA1(12), LAMA2(18), LAMA3(7), LAMA4(13), LAMA5(6), LAMB1(5), LAMB2(2), LAMB3(1), LAMB4(3), LAMC1(8), LAMC2(2), LAMC3(1), RELN(24), SDC1(1), SDC2(2), SDC3(1), SV2A(2), SV2B(4), SV2C(3), THBS1(1), THBS2(12), THBS3(3), THBS4(1), TNC(11), TNN(14), TNR(16), TNXB(15), VWF(15)	62294660	472	148	471	136	121	173	103	22	53	0	0.019	0.12
101	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(7), AKT1(1), GNAI1(2), GNB1(1), ITGAV(3), ITGB3(3), MAPK1(1), MAPK3(1), PDGFRA(8), PIK3CA(20), PIK3R1(1), PLCB1(6), PRKCA(4), PTK2(4), RAC1(1), SMPD1(3), SMPD2(1)	7352290	67	52	56	14	28	19	13	6	1	0	0.019	0.12
102	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(4), FADS2(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(5)	2761848	26	24	26	3	6	7	6	3	4	0	0.022	0.13
103	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(3), BRAF(7), C7orf16(1), CACNA1A(7), CRHR1(2), GNA12(1), GNAI1(2), GNAI3(1), GNAS(5), GNAZ(2), GRIA1(6), GRIA2(3), GRIA3(8), GRID2(12), GRM1(10), GRM5(11), GUCY1A2(10), GUCY1A3(5), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(4), HRAS(1), IGF1(3), ITPR1(4), ITPR2(11), ITPR3(1), KRAS(1), LYN(1), MAP2K1(2), MAPK1(1), MAPK3(1), NOS1(10), NOS3(1), NPR1(2), NPR2(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(5), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(4), PRKCG(8), PRKG1(4), PRKG2(3), RAF1(1), RYR1(24)	30301296	240	113	240	67	57	82	45	23	33	0	0.022	0.13
104	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(9), NRG2(2), NRG3(5), PRKCA(4), PSEN1(1)	2417774	21	21	21	6	3	8	3	2	5	0	0.023	0.14
105	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ALG6(2), CCKBR(1), CCR3(1), CELSR1(9), CELSR2(5), CELSR3(9), CHRM2(6), CHRM3(4), CXCR3(1), DRD4(1), EDNRA(1), EMR2(4), EMR3(3), F2R(2), FSHR(11), GHRHR(3), GPR116(5), GPR132(1), GPR133(1), GPR143(2), GPR17(3), GPR18(1), GPR55(1), GPR56(1), GPR61(2), GPR77(3), GRM1(10), GRPR(2), HRH4(3), LGR6(2), LPHN2(6), LPHN3(13), LTB4R2(1), NTSR1(3), OR8G2(1), P2RY13(1), PTGFR(2), SMO(1), SSTR2(2), TAAR5(5), TSHR(1), VN1R1(2)	18169350	138	87	138	50	36	48	31	9	14	0	0.026	0.15
106	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), ARHGAP5(1), BCAR1(5), CDC42(1), CDH5(1), CLDN1(2), CLDN10(4), CLDN16(4), CLDN17(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN6(1), CLDN8(1), CLDN9(3), CTNNA2(17), CTNNA3(10), CTNNB1(3), CTNND1(3), CXCR4(5), CYBB(6), ESAM(4), F11R(1), GNAI1(2), GNAI3(1), GRLF1(11), ICAM1(2), ITGA4(3), ITGAL(1), ITGAM(3), ITGB1(3), ITGB2(3), ITK(2), MAPK13(2), MAPK14(1), MLLT4(1), MMP2(3), MMP9(4), MSN(3), MYL2(1), MYLPF(1), NCF2(2), NCF4(1), NOX1(2), NOX3(5), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PRKCA(4), PRKCG(8), PTK2(4), PTPN11(2), PXN(3), RAC1(1), RAP1B(1), RAPGEF4(5), RASSF5(1), RHOH(3), ROCK1(5), ROCK2(3), THY1(2), TXK(3), VASP(2), VAV1(7), VAV2(3), VAV3(1), VCAM1(4), VCL(2)	34291522	258	122	247	86	73	86	52	24	23	0	0.026	0.15
107	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(2), FOS(1), HRAS(1), IGF1(3), IRS1(3), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PIK3CA(20), PIK3R1(1), PTPN11(2), RAF1(1), RASA1(5), SHC1(1), SOS1(6), SRF(2)	6671084	56	47	44	6	22	14	11	4	5	0	0.027	0.16
108	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(3), ARG1(2), ASL(3), CKB(1), CKM(2), CKMT2(1), CPS1(18), GATM(1), GLUD1(4), NAGS(1), ODC1(1), OTC(2), SMS(2)	4693148	41	35	40	6	13	12	9	1	6	0	0.027	0.16
109	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADCY1(7), ADRB2(3), GNAS(5), PLCE1(11), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	3962102	34	31	33	10	13	8	5	4	4	0	0.028	0.16
110	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(3), CA12(2), CA14(1), CA3(2), CA4(1), CA5A(1), CA5B(2), CA6(2), CA7(1), CA9(1), CPS1(18), GLS(2), GLUD1(4), GLUL(2)	5026186	42	36	41	3	14	12	10	2	4	0	0.031	0.17
111	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), CREB1(1), HRAS(1), MAPK1(1), MAPK3(1), MAPK7(1), MEF2A(2), MEF2C(3), MEF2D(2), NTRK1(3), PIK3CA(20), PIK3R1(1), PLCG1(1), RPS6KA1(2), SHC1(1)	5185496	41	38	30	9	19	10	7	3	2	0	0.034	0.19
112	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(2), C1QB(2), C1R(2), C1S(2), C2(1), C3(3), C5(1), C6(14), C7(7), C8A(3), C9(1), MASP1(9), MASP2(1), MBL2(3)	5864922	51	40	51	15	11	19	11	4	6	0	0.034	0.19
113	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(4), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH4A1(3), ALDH9A1(2), AMD1(1), AOC2(1), AOC3(3), ARG1(2), ASL(3), CKB(1), CKM(2), CKMT2(1), CPS1(18), DAO(1), GATM(1), GLUD1(4), GOT2(2), NOS1(10), NOS3(1), ODC1(1), OTC(2), P4HA1(2), P4HA2(2), P4HA3(3), RARS(4), SMS(2)	11910336	82	66	81	20	22	28	15	5	12	0	0.039	0.21
114	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1G(2), HDAC9(13), MEF2A(2), MEF2C(3), MEF2D(2)	2222864	22	20	22	7	11	3	4	2	2	0	0.043	0.23
115	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(7), HSD17B1(1), HSD17B4(1), HSD17B7(1), HSD3B1(4), HSD3B2(3)	2187264	18	18	18	4	6	4	4	3	1	0	0.045	0.24
116	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT3(2), IARS(3), IL13RA1(2), IL2RG(1), IL4(2), IL4R(1), INPP5D(5), JAK1(1), JAK2(3), JAK3(7), NR0B2(1), PI3(1), PIK3CA(20), PPP1R13B(4), RPS6KB1(1), SERPINA4(4), SHC1(1), SOS1(6), SOS2(5), STAT6(1), TYK2(5)	10061984	77	59	66	12	18	24	21	4	10	0	0.047	0.25
117	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(5), CXCR4(5), GNAI1(2), GNB1(1), HRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), NFKB1(2), PIK3C2G(6), PIK3CA(20), PIK3R1(1), PLCG1(1), PRKCA(4), PTK2(4), PXN(3), RAF1(1), RELA(2)	7686040	62	50	51	15	25	18	11	5	3	0	0.047	0.25
118	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(9), CD38(1), ENPP1(7), ENPP3(3), NADSYN1(6), NMNAT2(2), NNT(7), NT5E(2)	3938428	37	30	37	6	7	16	7	4	3	0	0.047	0.25
119	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CD3D(1), CXCR3(1), ETV5(1), IFNG(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL18R1(2), JAK2(3), JUN(3), MAP2K6(2), MAPK14(1), MAPK8(2), STAT4(4), TYK2(5)	4886634	35	34	34	7	7	12	8	3	5	0	0.050	0.26
120	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT3(2), HRAS(1), MAP2K1(2), NGFR(1), NTRK1(3), PIK3CA(20), PIK3CD(3), SHC1(1), SOS1(6)	4474208	40	34	29	9	17	11	8	2	2	0	0.051	0.26
121	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(5), GNB1(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4)	2534364	20	20	20	6	4	8	3	2	3	0	0.051	0.26
122	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(12), EP300(6), LPL(3), NCOA1(5), NCOA2(9), RXRA(1)	4966378	36	33	35	14	6	14	7	3	6	0	0.055	0.28
123	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), HLCS(5), SPCS1(1), SPCS3(2)	845144	9	8	9	1	0	2	2	1	4	0	0.057	0.28
124	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTB(1), ARHGEF2(5), CD14(1), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(3), CTTN(2), FYN(3), HCLS1(3), ITGB1(3), KRT18(2), NCK1(2), NCL(1), PRKCA(4), ROCK1(5), ROCK2(3), TLR4(10), TLR5(2), TUBA1B(1), TUBA3C(5), TUBA3D(2), TUBA3E(3), TUBA8(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(2), TUBB4(4), TUBB4Q(1), TUBB8(1), WAS(4), WASL(2), YWHAQ(1)	14327042	89	68	89	20	16	30	20	11	12	0	0.058	0.28
125	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTB(1), ARHGEF2(5), CD14(1), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(3), CTTN(2), FYN(3), HCLS1(3), ITGB1(3), KRT18(2), NCK1(2), NCL(1), PRKCA(4), ROCK1(5), ROCK2(3), TLR4(10), TLR5(2), TUBA1B(1), TUBA3C(5), TUBA3D(2), TUBA3E(3), TUBA8(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(2), TUBB4(4), TUBB4Q(1), TUBB8(1), WAS(4), WASL(2), YWHAQ(1)	14327042	89	68	89	20	16	30	20	11	12	0	0.058	0.28
126	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(3), C5(1), C6(14), C7(7), C8A(3), C9(1)	3440384	29	25	29	9	7	8	7	3	4	0	0.058	0.28
127	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(2), C1QB(2), C1R(2), C1S(2), C2(1), C3(3), C5(1), C6(14), C7(7), C8A(3), C8B(2), C9(1), MASP1(9)	5718962	49	38	49	17	12	17	11	4	5	0	0.060	0.29
128	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(1), JAK1(1), PTPRU(5), REG1A(11), STAT1(2), STAT2(1), TYK2(5)	3383424	28	25	28	7	2	15	4	4	3	0	0.061	0.29
129	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(2), FOS(1), HRAS(1), JUN(3), KLK2(1), MAP2K1(2), MAPK3(1), MAPK8(2), NGFR(1), PIK3CA(20), PIK3R1(1), PLCG1(1), RAF1(1), SHC1(1), SOS1(6)	5181046	44	38	32	7	20	9	11	3	1	0	0.061	0.29
130	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(6), COL4A2(6), COL4A3(5), COL4A4(9), COL4A5(2), COL4A6(6), F10(3), F11(3), F12(1), F2R(2), F5(14), F8(9), F9(4), FGA(5), FGB(3), FGG(1), KLKB1(4), SERPINC1(5), SERPING1(1)	12073384	89	63	89	21	16	38	20	5	10	0	0.061	0.29
131	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(2), FOS(1), HRAS(1), JAK1(1), JUN(3), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8(2), PDGFRA(8), PIK3CA(20), PIK3R1(1), PLCG1(1), PRKCA(4), RAF1(1), RASA1(5), SHC1(1), SOS1(6), SRF(2), STAT1(2), STAT3(1), STAT5A(2)	9354434	69	56	57	12	29	14	15	5	6	0	0.066	0.31
132	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(1), ESR1(5), GREB1(12), HSPB2(1), MTA1(1), MTA3(2), TUBA8(1)	3050208	24	24	24	10	9	7	6	1	1	0	0.069	0.32
133	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(7), ADCY2(14), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), CACNA1C(12), CACNA1D(3), CACNA1F(8), CACNA1S(5), CALML6(1), CAMK2B(2), CAMK2D(1), CDC42(1), EGFR(6), FSHB(1), GNAS(5), HBEGF(1), HRAS(1), ITPR1(4), ITPR2(11), ITPR3(1), JUN(3), KRAS(1), LHB(1), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K4(4), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(2), MAPK9(1), MMP14(2), MMP2(3), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(5), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLD1(6), PLD2(2), PRKACB(2), PRKACG(1), PRKCA(4), PRKCD(2), PRKX(1), RAF1(1), SOS1(6), SOS2(5)	35211604	211	117	209	59	58	70	40	22	21	0	0.070	0.32
134	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(7), ADCY2(14), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), AKAP1(2), AKAP11(7), AKAP12(3), AKAP3(6), AKAP5(1), AKAP6(11), AKAP7(2), AKAP8(3), AKAP9(7), ARHGEF1(2), CHMP1B(1), GNA12(1), GNA14(1), GNAI3(1), GNAL(1), GNAZ(2), GNB1(1), GNB2(2), GNB5(1), GNG12(1), GNG4(2), GNG5(1), HRAS(1), ITPR1(4), KCNJ3(7), KRAS(1), PDE1A(2), PDE1B(1), PDE1C(11), PDE4A(1), PDE4B(3), PDE4C(2), PDE4D(1), PDE7B(1), PDE8A(5), PDE8B(2), PLCB3(3), PPP3CA(2), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCI(4), PRKCQ(4), PRKD1(9), PRKD3(2), SLC9A1(3), USP5(1)	31769796	205	108	205	45	57	64	39	21	24	0	0.074	0.34
135	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GNS(1), GUSB(2), HEXA(4), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), LCT(14), SPAM1(3)	5629962	37	34	37	9	8	8	10	4	7	0	0.075	0.34
136	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(4), BDKRB1(1), BDKRB2(2), C1QA(2), C1QB(2), C1R(2), C1S(2), C2(1), C3(3), C3AR1(1), C4BPA(1), C5(1), C5AR1(1), C6(14), C7(7), C8A(3), C8B(2), C9(1), CD46(2), CFB(1), CFH(4), CFI(2), CPB2(2), CR1(4), CR2(9), F10(3), F11(3), F12(1), F13A1(3), F13B(7), F2R(2), F3(1), F5(14), F8(9), F9(4), FGA(5), FGB(3), FGG(1), KLKB1(4), KNG1(4), MASP1(9), MASP2(1), MBL2(3), PLAT(1), PLAU(2), PLG(1), SERPINA1(1), SERPINA5(1), SERPINC1(5), SERPIND1(1), SERPINF2(3), SERPING1(1), VWF(15)	24590700	182	99	182	58	41	60	45	18	18	0	0.077	0.35
137	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(2), FOS(1), HRAS(1), JAK2(3), JUN(3), MAP2K1(2), MAPK3(1), MPL(2), PIK3CA(20), PIK3R1(1), PLCG1(1), PRKCA(4), RAF1(1), RASA1(5), SHC1(1), SOS1(6), STAT1(2), STAT3(1), STAT5A(2)	8070520	59	49	47	7	23	10	14	4	8	0	0.079	0.36
138	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(1), GHR(2), HRAS(1), IGF1(3), PIK3CA(20), PIK3R1(1), SHC1(1), SOD2(1)	3592396	30	28	19	6	15	8	5	2	0	0	0.081	0.36
139	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(1), AGTR1(2), AGTR2(3), CMA1(2), COL4A1(6), COL4A2(6), COL4A3(5), COL4A4(9), COL4A5(2), COL4A6(6)	6924734	45	41	45	14	10	22	7	0	6	0	0.082	0.37
140	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), BCL2L1(1), CASP9(2), CDC42(1), CHUK(2), H2AFX(1), HRAS(1), MAP2K1(2), MAPK3(1), NFKB1(2), PIK3CA(20), PIK3R1(1), RAC1(1), RAF1(1), RALA(2), RALBP1(1), RALGDS(1), RELA(2)	5225724	43	36	32	7	19	8	7	6	3	0	0.083	0.37
141	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(7), ADRB2(3), CFTR(5), GNAS(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	3468864	28	25	28	8	9	7	6	3	3	0	0.086	0.37
142	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(1), LCT(14), MPI(1), PYGM(4), TPI1(3), TREH(1)	3613934	27	25	27	9	8	3	9	3	4	0	0.086	0.37
143	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(7), GNAS(5), GNB1(1), PRKAR1A(2)	1804742	15	15	15	5	4	5	3	2	1	0	0.091	0.39
144	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(1), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), ELAVL1(1), FLT1(8), FLT4(3), HIF1A(1), HRAS(1), KDR(12), NOS3(1), PIK3CA(20), PIK3R1(1), PLCG1(1), PRKCA(4), PTK2(4), PXN(3), SHC1(1), VHL(1)	9270240	67	53	56	19	25	16	10	9	7	0	0.092	0.39
145	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), JAK2(3), STAT4(4), TYK2(5)	3830026	26	25	26	7	4	7	7	2	6	0	0.093	0.39
146	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(5), ABCA10(8), ABCA12(7), ABCA13(25), ABCA2(6), ABCA3(3), ABCA4(10), ABCA5(4), ABCA6(6), ABCA7(3), ABCA8(5), ABCA9(9), ABCB1(15), ABCB10(4), ABCB11(5), ABCB4(6), ABCB5(6), ABCB6(3), ABCB7(2), ABCB8(1), ABCB9(3), ABCC1(4), ABCC10(5), ABCC11(3), ABCC12(12), ABCC2(4), ABCC3(1), ABCC4(1), ABCC5(4), ABCC6(1), ABCC8(5), ABCC9(9), ABCD1(3), ABCD2(10), ABCD4(1), ABCG1(1), ABCG2(1), ABCG4(1), ABCG5(1), ABCG8(4), CFTR(5), TAP1(2)	32453316	214	114	214	70	48	76	51	14	23	2	0.095	0.40
147	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(1), APC(9), AR(4), BRAF(7), CCL16(1), DAG1(1), EGFR(6), GNAI1(2), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), KCNJ3(7), KCNJ5(2), KCNJ9(2), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(2), PIK3CA(20), PIK3CD(3), PIK3R1(1), PITX2(3), PTX3(2), RAF1(1)	14631244	98	73	86	19	35	26	22	5	10	0	0.097	0.40
148	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(9), BST1(1), CD38(1), ENPP1(7), ENPP3(3), NADSYN1(6), NMNAT2(2), NNT(7), NT5C1A(2), NT5C1B(1), NT5C2(2), NT5C3(3), NT5E(2), NUDT12(2)	5841960	48	38	48	10	10	20	9	4	5	0	0.097	0.40
149	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), CHRNB1(1), CHRNG(4), MUSK(2), PIK3CA(20), PIK3R1(1), PTK2(4), RAPSN(3), TERT(3)	4523692	39	34	28	10	22	10	5	1	1	0	0.10	0.42
150	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), CASP9(2), CHUK(2), GHR(2), NFKB1(2), PDPK1(1), PIK3CA(20), PIK3R1(1), RELA(2)	3843198	33	28	22	9	14	7	6	4	2	0	0.10	0.42
151	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(1), IFNGR1(3), JAK1(1), JAK2(3), PLA2G2A(1), PTPRU(5), REG1A(11), STAT1(2)	3103786	27	23	27	5	2	13	8	1	3	0	0.10	0.42
152	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCL3(2), CCR1(2), CCR3(1), CCR4(3), CD4(1), CXCR3(1), CXCR4(5), IFNG(1), IFNGR1(3), IFNGR2(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL18R1(2), IL4(2), IL4R(1), TGFB1(1), TGFB2(2)	5101124	37	32	37	13	8	12	9	0	8	0	0.10	0.42
153	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), E2F1(2), HRAS(1), MAPK1(1), MAPK3(1), NFKB1(2), PAK1(1), PIK3CA(20), PIK3R1(1), RAC1(1), RAF1(1), RB1(7), RELA(2)	5529036	41	36	30	3	16	10	5	4	6	0	0.10	0.42
154	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(2), EGF(6), EGFR(6), FOS(1), HRAS(1), JAK1(1), JUN(3), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8(2), PIK3CA(20), PIK3R1(1), PLCG1(1), PRKCA(4), RAF1(1), RASA1(5), SHC1(1), SOS1(6), SRF(2), STAT1(2), STAT3(1), STAT5A(2)	10098296	73	57	60	11	29	17	15	4	8	0	0.11	0.44
155	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(3), ITPKA(1), ITPKB(4), OCRL(5), PIK3C2A(4), PIK3C2B(6), PIK3C2G(6), PIK3CA(20), PIK3CB(2), PIK3CG(9), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCG1(1), PLCG2(3)	12318668	96	63	85	24	37	20	21	6	12	0	0.11	0.45
156	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(1), EGF(6), EGFR(6), HRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), PTPRB(13), RAF1(1), RASA1(5), SHC1(1), SOS1(6)	6589916	44	39	43	7	11	13	8	3	9	0	0.11	0.45
157	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(5), AGT(1), AGTR2(3), EDNRA(1), EDNRB(3), EGF(6), EGFR(6), FOS(1), HRAS(1), JUN(3), MYC(1), NFKB1(2), PLCG1(1), PRKCA(4), RELA(2)	5560898	40	34	38	11	8	13	7	4	8	0	0.12	0.46
158	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(2), ACTN1(2), AKT1(1), AKT3(2), ARHGEF6(2), ARHGEF7(3), BCAR1(5), BRAF(7), CDC42(1), CDKN2A(22), CSE1L(4), DOCK1(3), EPHB2(4), FYN(3), GRLF1(11), ILK(1), ITGA1(3), ITGA10(5), ITGA11(3), ITGA2(5), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGB3BP(1), MAP3K11(2), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MRAS(2), MYLK(5), MYLK2(2), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PIK3CA(20), PIK3CB(2), PKLR(3), PLCG1(1), PLCG2(3), PTEN(13), PTK2(4), RAF1(1), RALA(2), RHO(1), ROCK1(5), ROCK2(3), SHC1(1), SOS1(6), SOS2(5), TLN1(3), TLN2(11), VASP(2), WAS(4)	33437656	226	115	212	62	54	73	48	10	41	0	0.12	0.46
159	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(7), ARHGEF1(2), F2R(2), F2RL3(1), GNA12(1), GNAI1(2), GNB1(1), MAP3K7(2), PIK3CA(20), PIK3R1(1), PLCB1(6), PPP1R12B(4), PRKCA(4), ROCK1(5)	7032780	58	46	47	12	22	19	11	4	2	0	0.12	0.46
160	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(3), ACVRL1(3), AKT1(1), BMPR1A(3), BUB1(3), CDKL2(2), CDS1(2), CLK1(1), CLK2(1), CLK4(2), COL4A3BP(3), CSNK2A1(2), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKZ(3), IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(3), ITPKA(1), ITPKB(4), MOS(4), NEK1(3), OCRL(5), PAK4(1), PIK3C2A(4), PIK3C2B(6), PIK3C2G(6), PIK3CA(20), PIK3CB(2), PIK3CG(9), PIM2(2), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCG1(1), PLCG2(3), PLK3(3), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCQ(4), PRKD1(9), PRKG1(4), RAF1(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA4(1), RPS6KB1(1), STK11(3), VRK1(1)	31164596	208	107	196	48	67	58	42	15	26	0	0.12	0.47
161	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), AGPAT3(1), AGPAT6(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), CEL(1), DAK(1), DGAT2(2), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKI(7), DGKZ(3), GK(4), GK2(5), GLA(2), GPAM(2), LCT(14), LIPA(2), LIPC(1), LIPF(1), LIPG(2), LPL(3), MGLL(1), PNLIP(9), PNLIPRP1(3), PNLIPRP2(2), PNPLA3(1), PPAP2B(1)	15884364	99	76	99	36	27	37	15	12	8	0	0.13	0.48
162	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(5), CD14(1), CD19(2), CD1A(4), CD1B(5), CD1C(5), CD1D(3), CD1E(4), CD2(1), CD22(5), CD33(2), CD34(2), CD36(1), CD37(2), CD38(1), CD3D(1), CD4(1), CD44(3), CD5(2), CD8B(1), CD9(1), CR1(4), CR2(9), CSF1(2), CSF1R(3), CSF3R(5), DNTT(2), EPOR(2), FCER2(1), FCGR1A(1), FLT3(4), GP1BA(2), GP5(3), GP9(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), IL11RA(1), IL1B(1), IL1R2(3), IL4(2), IL4R(1), IL5RA(2), IL6R(1), IL7R(2), ITGA1(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGAM(3), ITGB3(3), KIT(5), MME(8), MS4A1(2), TFRC(2), TPO(10)	21879404	157	93	157	62	38	68	29	5	17	0	0.13	0.48
163	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(6), ADCY3(4), ADCY9(3), ARF1(1), ARF5(3), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V1A(3), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ERO1L(1), GNAS(5), PDIA4(1), PLCG1(1), PLCG2(3), PRKCA(4), SEC61A1(2), SEC61A2(1), TRIM23(2)	10010542	61	52	61	16	12	20	17	6	6	0	0.13	0.48
164	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), HEXA(4), LCT(14), SLC33A1(2), ST3GAL1(1), ST3GAL5(2), ST6GALNAC3(3), ST6GALNAC5(2), ST8SIA1(2)	4440388	31	28	31	13	11	5	7	3	5	0	0.14	0.52
165	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(3), AKT1(1), GNAS(5), GNB1(1), NFKB1(2), NOS3(1), PIK3CA(20), PIK3R1(1), RELA(2), SYT1(3)	4937720	39	33	28	10	18	7	8	5	1	0	0.14	0.52
166	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(7), CPEB1(1), EGFR(6), ERBB2(1), ERBB4(9), ETS1(2), ETV6(4), FMN2(21), KRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), NOTCH1(10), NOTCH2(6), NOTCH3(4), NOTCH4(3), PIWIL1(5), PIWIL2(3), PIWIL3(3), RAF1(1), SOS1(6), SOS2(5), SPIRE1(1)	14423162	103	70	101	33	21	42	17	7	16	0	0.14	0.52
167	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(2), FBP2(1), GOT2(2), GPT(1), GPT2(2), MDH1(1), MDH2(1), ME3(1), PGK1(1), PGK2(4), PKLR(3), PKM2(2), RPIA(1), TKT(1), TKTL2(9), TPI1(3)	5308138	36	33	36	17	7	10	10	5	4	0	0.14	0.53
168	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(5), AASDHPPT(1), AASS(6), KARS(2)	1862592	15	15	15	5	2	5	4	2	2	0	0.15	0.53
169	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(12), EP300(6), FYN(3), IL2RG(1), IL7R(2), JAK1(1), JAK3(7), LCK(2), NMI(1), PIK3CA(20), PIK3R1(1), STAT5A(2)	7626588	58	47	46	14	19	18	13	4	4	0	0.15	0.53
170	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5(1), CFL1(2), CHN1(2), MAP3K1(2), MYL2(1), MYLK(5), NCF2(2), PAK1(1), PDGFRA(8), PIK3CA(20), PIK3R1(1), PLD1(6), PPP1R12B(4), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(5), VAV1(7)	9449664	70	54	59	18	22	21	18	7	2	0	0.15	0.55
171	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(5), FYN(3), LRP8(1), RELN(24)	3755444	34	25	34	9	7	9	10	7	1	0	0.15	0.55
172	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), CREBBP(12), DFFB(2), GZMA(4), GZMB(1), PRF1(1)	2860104	21	20	21	9	6	6	3	2	4	0	0.15	0.55
173	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT3(2), CASP9(2), CDC42(1), CHP(2), HRAS(1), KDR(12), KRAS(1), MAP2K1(2), MAPK1(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPKAPK2(1), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NOS3(1), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(5), PLCG1(1), PLCG2(3), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKCA(4), PRKCG(8), PTK2(4), PXN(3), RAC1(1), RAF1(1), SHC2(2), SPHK2(1)	19897018	141	85	130	40	49	37	20	19	16	0	0.15	0.55
174	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(6), ACTN3(2), BCAR1(5), CTNNA2(17), CTNNB1(3), PTK2(4), PXN(3), VCL(2)	5688346	44	36	44	25	12	19	6	6	1	0	0.16	0.55
175	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), HRAS(1), IRS1(3), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3CA(20), PIK3R1(1), RAF1(1), SHC1(1), SOS1(6)	5084392	38	34	27	3	17	9	9	2	1	0	0.16	0.55
176	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(2), GLS(2), GLUD1(4)	1445894	11	11	11	5	1	7	2	0	1	0	0.17	0.58
177	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GHR(2), HRAS(1), INSR(7), IRS1(3), JAK2(3), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3CA(20), PIK3R1(1), PLCG1(1), PRKCA(4), RAF1(1), RPS6KA1(2), SHC1(1), SLC2A4(2), SOS1(6), SRF(2), STAT5A(2)	8934888	62	51	51	10	21	17	16	4	4	0	0.18	0.61
178	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(2), B4GALT6(1), CERK(3), ENPP7(4), GAL3ST1(1), GALC(1), GLA(2), LCT(14), NEU1(2), NEU2(2), PPAP2B(1), SGMS1(2), SGMS2(1), SGPP1(2), SMPD1(3), SMPD2(1), SMPD3(3), SMPD4(8), SPHK2(1), SPTLC2(3), UGT8(5)	9827558	63	50	63	18	17	15	14	9	8	0	0.18	0.61
179	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(3), C5(1), C6(14), C7(7), ICAM1(2), ITGA4(3), ITGAL(1), ITGB1(3), ITGB2(3), SELP(8), SELPLG(1), VCAM1(4)	6722882	50	39	50	12	12	13	12	6	7	0	0.18	0.61
180	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), DRD1(1), DRD2(2), GRM1(10), PLCB1(6), PPP1R1B(1), PPP3CA(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	4232840	31	27	31	8	10	11	4	3	3	0	0.20	0.67
181	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(1), GALNT2(2), GALNT3(2), GALNT6(2), GALNT8(2), GCNT1(2), ST3GAL1(1), ST3GAL4(2), WBSCR17(9)	3854234	24	23	23	10	4	7	8	2	3	0	0.20	0.67
182	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(7), CD3D(1), CD4(1), CREBBP(12), GNAS(5), GNB1(1), HLA-DRA(1), HLA-DRB1(1), LCK(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(3), ZAP70(2)	6185678	44	37	44	18	11	17	5	5	6	0	0.20	0.67
183	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(7), CD3D(1), CD4(1), CREBBP(12), GNAS(5), GNB1(1), HLA-DRA(1), HLA-DRB1(1), LCK(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(3), ZAP70(2)	6185678	44	37	44	18	11	17	5	5	6	0	0.20	0.67
184	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(1), UGDH(2), UGP2(4), UXS1(3)	1352088	11	10	11	0	0	4	4	1	2	0	0.20	0.67
185	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(3), EGF(6), EGFR(6), MET(3), PDGFRA(8), PRKCA(4), SH3GLB1(1), SH3KBP1(4)	5214866	36	32	35	6	10	12	6	3	5	0	0.20	0.67
186	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GNS(1), GUSB(2), HEXA(4), IDS(1), IDUA(2), LCT(14)	3961034	25	23	25	5	6	4	6	4	5	0	0.21	0.68
187	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(3)	435032	4	4	4	1	1	1	2	0	0	0	0.21	0.68
188	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(6), APOBEC2(1), APOBEC3F(1), APOBEC4(3)	1962984	15	14	15	4	5	3	3	1	3	0	0.21	0.69
189	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(3), NR0B2(1), NR1H3(2), NR1H4(2), RXRA(1)	1464406	10	10	10	3	2	3	2	1	2	0	0.21	0.69
190	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(9), PDXP(1), PSAT1(1)	1306342	11	10	11	2	1	4	2	3	1	0	0.22	0.72
191	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(2), CR1(4), CR2(9), FCGR2B(2), HLA-DRA(1), HLA-DRB1(1), ICAM1(2), ITGAL(1), ITGB2(3), PTPRC(3)	4122124	28	26	28	13	7	9	4	5	3	0	0.22	0.72
192	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3D(1), GZMB(1), HLA-A(7), ICAM1(2), ITGAL(1), ITGB2(3), PRF1(1)	2341056	17	15	17	6	1	4	3	3	4	2	0.23	0.72
193	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT1(1), AKT3(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(7), BTK(4), CDC42(1), CFL1(2), CFL2(1), GDI1(1), GDI2(1), INPPL1(3), ITPR1(4), ITPR2(11), ITPR3(1), MYLK(5), MYLK2(2), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PDK1(1), PIK3CA(20), PIK3CD(3), PIK3CG(9), PIK3R1(1), PITX2(3), PPP1R13B(4), PTEN(13), RACGAP1(1), RHO(1), ROCK1(5), ROCK2(3), WASL(2)	19220618	121	81	109	36	32	30	27	10	22	0	0.23	0.72
194	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), EPX(4), LPO(2), MPO(3), MTHFR(1), PRDX6(1), TPO(10)	3156652	22	21	22	9	3	9	8	2	0	0	0.23	0.72
195	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA1(1), HEXA(4), LCT(14), MAN2C1(5), MANBA(2), NEU1(2), NEU2(2)	4555198	32	26	32	9	9	6	10	3	4	0	0.23	0.72
196	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), EPX(4), LPO(2), MPO(3), PRDX1(1), PRDX6(1), TPO(10)	3214324	22	21	22	10	3	8	9	2	0	0	0.23	0.74
197	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	134924	1	1	1	0	0	0	1	0	0	0	0.25	0.78
198	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(12), GNA12(1), PRKACB(2), PRKACG(1), PRKAR2B(2)	2728562	18	18	18	5	4	8	3	2	1	0	0.25	0.79
199	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(2), C1QB(2), C1R(2), C1S(2), C2(1), C3(3), C5(1), C6(14), C7(7), C8A(3), C9(1)	4840888	38	29	38	13	9	13	8	3	5	0	0.26	0.79
200	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(9), CDH1(3), CREBBP(12), EP300(6), MAP2K1(2), MAP3K7(2), MAPK3(1), TGFB1(1), TGFB2(2), TGFBR2(3)	6897500	41	38	40	11	6	16	10	3	6	0	0.26	0.79
201	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT3(2), BCR(1), BLNK(1), BTK(4), CD19(2), CD22(5), CD81(1), CR2(9), DAG1(1), FLOT1(1), GSK3A(3), INPP5D(5), ITPR1(4), ITPR2(11), ITPR3(1), LYN(1), MAP4K1(2), MAPK1(1), MAPK3(1), NFATC2(4), NR0B2(1), PDK1(1), PIK3CA(20), PIK3CD(3), PIK3R1(1), PLCG2(3), PPP1R13B(4), PPP3CA(2), PPP3CB(4), PPP3CC(2), PTPRC(3), RAF1(1), SHC1(1), SOS1(6), SOS2(5), SYK(1), VAV1(7)	20172206	126	81	115	35	39	33	23	12	19	0	0.26	0.79
202	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CKS1B(1), CUL1(2), E2F1(2), RB1(7), RBX1(1), SKP2(1), UBE2M(1)	2348354	15	14	15	1	2	6	0	1	6	0	0.26	0.81
203	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), HLA-DRA(1), HLA-DRB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL18R1(2), IL4(2), IL4R(1)	3417422	22	20	22	8	3	7	6	0	6	0	0.27	0.81
204	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(7), ADCY2(14), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), ADSL(1), ADSS(1), ADSSL1(1), AK5(3), AK7(1), AMPD1(4), AMPD2(1), AMPD3(6), CANT1(1), DCK(1), ENPP1(7), ENPP3(3), ENTPD1(1), ENTPD2(1), ENTPD3(1), ENTPD6(3), GART(1), GDA(6), GUCY1A2(10), GUCY1A3(5), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(4), GUK1(2), HPRT1(1), IMPDH1(1), NME4(1), NME7(2), NPR1(2), NPR2(2), NT5C1A(2), NT5C1B(1), NT5C2(2), NT5C3(3), NT5E(2), NUDT9(2), PAPSS2(1), PDE10A(5), PDE11A(8), PDE1A(2), PDE1C(11), PDE2A(2), PDE3B(3), PDE4A(1), PDE4B(3), PDE4C(2), PDE4D(1), PDE5A(4), PDE6H(2), PDE7B(1), PDE8A(5), PDE8B(2), PDE9A(2), PFAS(4), PKLR(3), PKM2(2), PNPT1(2), POLA1(4), POLD1(2), POLD3(1), POLE2(2), POLE4(1), POLR1A(2), POLR1B(2), POLR1D(1), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(1), PPAT(2), PRIM1(2), PRIM2(10), PRPS1(1), PRPS1L1(1), PRPS2(1), RFC5(1), RRM1(1), RRM2B(2), XDH(8)	44705590	262	122	262	92	70	90	44	20	38	0	0.27	0.81
205	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(5), ESR2(1), ITPKA(1), PDE1A(2), PDE1B(1), PLCB1(6), PLCB2(5), PRL(1), VIP(1)	3042376	23	21	23	8	10	7	3	2	1	0	0.27	0.81
206	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2	FAH(1), GSTZ1(2)	353152	3	3	3	1	1	0	0	1	1	0	0.27	0.81
207	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(5), P2RY1(2), P2RY2(1), P2RY6(1)	1601110	12	11	12	4	5	5	1	0	1	0	0.27	0.81
208	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3D(1), FOS(1), FYN(3), HRAS(1), JUN(3), LCK(2), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB1(2), PIK3CA(20), PIK3R1(1), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKCA(4), RAC1(1), RAF1(1), RASA1(5), RELA(2), SHC1(1), SOS1(6), SYT1(3), VAV1(7), ZAP70(2)	12961782	89	63	77	12	32	19	16	13	9	0	0.28	0.82
209	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1B(3), ACVR1C(3), ACVR2A(3), ACVRL1(3), AMHR2(4), BMP4(1), BMP5(5), BMPR1A(3), CHRD(3), COMP(1), CREBBP(12), CUL1(2), DCN(1), EP300(6), GDF5(4), GDF6(2), ID2(1), ID4(1), IFNG(1), INHBA(4), INHBC(1), LEFTY2(2), LTBP1(10), MAPK1(1), MAPK3(1), MYC(1), NODAL(3), PITX2(3), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), RBL1(5), RBL2(5), RBX1(1), ROCK1(5), ROCK2(3), RPS6KB1(1), SKP1(1), SMAD1(3), SMAD2(1), SMAD4(2), SMAD7(2), SMURF1(2), SP1(1), TGFB1(1), TGFB2(2), TGFBR2(3), THBS1(1), THBS2(12), THBS3(3), THBS4(1), ZFYVE16(3), ZFYVE9(5)	27101212	158	98	156	44	26	55	38	17	22	0	0.28	0.82
210	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(1), CD80(2), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL4(2)	1077612	8	8	8	3	0	3	2	1	2	0	0.28	0.82
211	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(5), ABAT(2), ACY3(2), ADSL(1), ADSS(1), ADSSL1(1), AGXT2(1), ASL(3), ASNS(3), CAD(8), DARS(1), DARS2(5), DDO(2), DLAT(1), DLD(2), GAD1(4), GAD2(5), GOT2(2), GPT(1), GPT2(2), NARS(2), NARS2(2), PC(2), PDHA1(2), PDHA2(5)	10270600	66	53	66	21	13	29	11	6	7	0	0.28	0.82
212	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), AGPAT3(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), CEL(1), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKZ(3), GK(4), GLA(2), LCT(14), LIPC(1), LIPF(1), LIPG(2), LPL(3), PNLIP(9), PNLIPRP1(3), PNLIPRP2(2), PPAP2B(1)	13024438	77	62	77	31	20	29	13	8	7	0	0.28	0.82
213	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(5), INPP5E(2), INPPL1(3), ITPK1(1), ITPKA(1), ITPKB(4), OCRL(5), PI4KA(4), PI4KB(1), PIK3C3(3), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCD3(1), PLCE1(11), PLCG1(1), PLCG2(3), PLCZ1(4), PTEN(13), SYNJ1(2), SYNJ2(3)	20365336	146	83	134	35	50	34	28	12	22	0	0.28	0.82
214	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX15(2), CYP4F2(3), CYP4F3(2), EPX(4), GGT1(1), LPO(2), LTA4H(2), MPO(3), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(5), PRDX1(1), PRDX6(1), PTGS1(2), TBXAS1(2), TPO(10)	7586538	54	43	54	24	11	19	17	3	4	0	0.29	0.83
215	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(2), UGDH(2), UGP2(4), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2)	6739792	43	39	43	9	10	12	15	3	3	0	0.30	0.85
216	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(9), CREBBP(12), CTNNB1(3), DVL1(3), EP300(6), FZD1(1), HDAC1(2), LEF1(3), PITX2(3), TRRAP(11)	8810288	53	46	52	12	9	16	17	3	8	0	0.30	0.85
217	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), GOT2(2), TAT(1), TYR(3)	1255434	8	8	8	2	2	4	0	1	1	0	0.30	0.85
218	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(9), CAV3(1), DAG1(1), DLG4(1), EPHB2(4), GNAI1(2), ITPR1(4), ITPR2(11), ITPR3(1), KCNJ3(7), KCNJ5(2), KCNJ9(2), MAPK1(1), PITX2(3), PTX3(2), RAC1(1), RHO(1), RYR1(24)	12603824	78	60	78	20	16	29	16	6	11	0	0.30	0.85
219	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IFNG(1), IL12A(1), IL12B(2)	802958	5	5	5	1	0	1	2	0	2	0	0.30	0.85
220	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(4), HDC(3), PNMT(2), TH(1), TPH1(1)	1656468	12	11	12	2	2	6	2	1	1	0	0.31	0.87
221	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), RB1(7), SP1(1), SP3(1)	1794596	10	10	10	1	1	3	0	0	6	0	0.31	0.87
222	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(3), JAK3(7), PIAS1(2), PIAS3(2), PTPRU(5), REG1A(11)	3829492	31	24	31	5	1	17	8	2	3	0	0.31	0.87
223	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	109	A4GNT(5), ALG1(1), ALG13(6), ALG2(2), ALG6(2), B3GALT6(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT1(1), B4GALT3(1), B4GALT4(1), B4GALT5(2), C1GALT1C1(1), CHPF(1), CHST1(2), CHST12(1), CHST2(3), CHST3(2), CHST4(2), CHST6(3), DDOST(1), EXT1(2), EXT2(1), EXTL1(1), EXTL3(1), FUT8(2), GALNT1(1), GALNT10(1), GALNT11(2), GALNT12(3), GALNT13(10), GALNT14(3), GALNT2(2), GALNT3(2), GALNT5(6), GALNT6(2), GALNT8(2), GALNTL1(3), GALNTL4(3), GALNTL5(3), GANAB(5), GCNT1(2), GCNT3(2), HS3ST2(1), HS3ST5(4), HS6ST1(2), HS6ST3(2), MAN1A1(3), MAN1A2(3), MAN1C1(3), MAN2A1(3), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(4), NDST1(2), NDST2(1), NDST3(4), NDST4(11), OGT(2), RPN1(1), ST3GAL1(1), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(3), STT3B(1), WBSCR17(9), XYLT1(2)	30285098	178	107	176	62	38	68	35	20	17	0	0.32	0.88
224	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(1), AASS(6), KARS(2)	1265758	10	10	10	3	2	4	3	0	1	0	0.32	0.89
225	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(2), CAPN2(2), CAPNS2(1), CXCR3(1), EGF(6), EGFR(6), HRAS(1), ITGA1(3), ITGB1(3), MAPK1(1), MAPK3(1), MYL2(1), MYLK(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTK2(4), PXN(3), TLN1(3)	8846956	52	46	51	13	15	16	7	7	7	0	0.33	0.90
226	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA4(1), ANXA5(2), ANXA6(4), CYP11A1(2), EDNRA(1), EDNRB(3), HSD11B1(3), HSD11B2(1), PLA2G4A(5), PRL(1), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), PTGS1(2), TBXAS1(2)	5652568	39	33	39	15	8	14	8	3	6	0	0.33	0.90
227	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(7), AP2A1(2), AP2M1(1), DNM1(1), EPN1(2), EPS15(4), PICALM(4), PPP3CA(2), PPP3CB(4), PPP3CC(2), SYNJ1(2), SYNJ2(3), SYT1(3)	6051110	37	34	37	9	11	8	6	5	7	0	0.33	0.90
228	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(2), FUCA1(1), HEXA(4), LCT(14), MAN2B1(1), MAN2B2(3), MAN2C1(5), MANBA(2), NEU1(2), NEU2(2)	5600236	36	29	36	11	9	8	11	4	4	0	0.34	0.92
229	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(2)	579390	4	4	4	0	1	1	1	1	0	0	0.34	0.92
230	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), CFL1(2), GNAS(5), GNB1(1), HRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(1), NOX1(2), PIK3C2G(6), PLCB1(6), PPP1R12B(4), PRKCA(4), PTK2(4), RAF1(1), ROCK2(3)	6923488	45	39	45	14	12	18	8	3	4	0	0.35	0.93
231	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	192952	1	1	1	0	0	0	0	0	1	0	0.35	0.93
232	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(7), CREB1(1), CREB3(2), CREB5(3), DUSP4(2), DUSP6(1), DUSP9(2), EEF2K(3), MAP2K1(2), MAPK1(1), MAPK3(1), MKNK2(1), MOS(4), NFKB1(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), SHC1(1), SOS1(6), SOS2(5), TRAF3(1)	8109146	51	42	50	11	8	13	17	3	10	0	0.35	0.93
233	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(9), CREBBP(12), CSNK1A1(2), CSNK2A1(2), CTBP1(1), CTNNB1(3), DVL1(3), FZD1(1), HDAC1(2), MAP3K7(2), MYC(1), NLK(2), PPARD(1), TLE1(4), WIF1(3)	7875610	48	41	48	10	11	14	11	5	7	0	0.35	0.93
234	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(6), CCND2(3), DAZL(1), DMC1(1), EGR1(2), ESR2(1), FSHR(11), INHA(3), LHCGR(7), MLH1(1), MSH5(2), NCOR1(5), NRIP1(3), PGR(3), PRLR(5), PTGER2(2), SMPD1(3), VDR(3), ZP2(2)	9486510	64	47	64	24	20	20	8	7	9	0	0.35	0.93
235	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(1), ACTB(1), ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), ACVR1B(3), ACVR1C(3), CDC42(1), CDH1(3), CREBBP(12), CSNK2A1(2), CTNNA2(17), CTNNA3(10), CTNNB1(3), CTNND1(3), EGFR(6), EP300(6), ERBB2(1), FARP2(6), FER(2), FGFR1(1), FYN(3), INSR(7), IQGAP1(6), LEF1(3), LMO7(6), MAP3K7(2), MAPK1(1), MAPK3(1), MET(3), MLLT4(1), NLK(2), PARD3(5), PTPN1(1), PTPRB(13), PTPRF(6), PTPRJ(2), PTPRM(6), PVRL1(2), PVRL3(2), PVRL4(5), RAC1(1), SMAD2(1), SMAD4(2), SNAI1(3), SNAI2(2), SORBS1(5), SSX2IP(1), TCF7(1), TGFBR2(3), TJP1(8), VCL(2), WAS(4), WASF3(1), WASL(2), YES1(1)	32265170	209	107	207	65	39	71	53	21	25	0	0.36	0.94
236	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(3), CADM1(2), CADM3(3), CD2(1), CD22(5), CD226(3), CD276(1), CD34(2), CD4(1), CD40(1), CD40LG(2), CD58(1), CD6(1), CD80(2), CD86(1), CD8B(1), CDH1(3), CDH2(9), CDH3(1), CDH4(6), CDH5(1), CLDN1(2), CLDN10(4), CLDN16(4), CLDN17(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN6(1), CLDN8(1), CLDN9(3), CNTN1(9), CNTN2(1), CNTNAP1(3), CNTNAP2(23), ESAM(4), F11R(1), GLG1(3), HLA-A(7), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-G(1), ICAM1(2), ICAM3(2), ICOS(2), ITGA4(3), ITGA6(3), ITGA8(8), ITGAL(1), ITGAM(3), ITGAV(3), ITGB1(3), ITGB2(3), ITGB7(1), ITGB8(3), L1CAM(2), MADCAM1(1), MAG(4), NCAM1(2), NCAM2(10), NEGR1(2), NEO1(3), NFASC(5), NLGN1(7), NLGN2(1), NLGN3(4), NRCAM(3), NRXN1(15), NRXN2(7), NRXN3(7), PTPRC(3), PTPRF(6), PTPRM(6), PVRL1(2), PVRL3(2), SDC1(1), SDC2(2), SDC3(1), SELE(4), SELL(2), SELP(8), SELPLG(1), SIGLEC1(7), VCAM1(4), VCAN(15)	40778020	306	120	305	112	78	111	65	20	30	2	0.36	0.94
237	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(12), EP300(6), ESR1(5), MAPK1(1), MAPK3(1)	4039354	25	24	24	6	5	9	6	2	3	0	0.36	0.94
238	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(7), GNAS(5), GNB1(1), PRKAA2(3), PRKACB(2), PRKACG(1), PRKAG2(4), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	4084922	28	24	28	7	8	9	5	3	3	0	0.36	0.94
239	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOA(1), ALDOB(2), TPI1(3)	1036850	7	7	7	3	2	2	3	0	0	0	0.37	0.94
240	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(2), ARSB(1), FUCA1(1), GNS(1), GUSB(2), HEXA(4), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), LCT(14), MAN2B1(1), MAN2B2(3), MAN2C1(5), MANBA(2), NEU1(2), NEU2(2), SPAM1(3)	9523534	55	44	55	15	11	14	17	5	8	0	0.37	0.94
241	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT3(3), FUT5(4), FUT6(2)	1397656	9	8	9	2	2	3	3	1	0	0	0.37	0.94
242	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), GPI(5), HK1(3), PFKL(2), PGK1(1), PKLR(3), TPI1(3)	2381818	19	15	19	4	6	5	5	0	3	0	0.37	0.94
243	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(4), ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), ALDH3B2(1), AOC2(1), AOC3(3), AOX1(9), DBH(1), DCT(1), DDC(2), FAH(1), GOT2(2), GSTZ1(2), HPD(1), PNMT(2), TAT(1), TH(1), TPO(10), TYR(3)	8331112	52	44	52	15	14	22	6	8	2	0	0.37	0.94
244	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(6), EGFR(6), ERBB3(3), NRG1(3), UBE2D1(1)	2762204	19	17	18	4	6	6	3	1	3	0	0.38	0.95
245	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(1), AKT3(2), GSK3A(3), IL4R(1), IRS1(3), IRS2(2), JAK1(1), JAK3(7), MAP4K1(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(20), PIK3CD(3), PIK3R1(1), PPP1R13B(4), RAF1(1), SHC1(1), SOS1(6), SOS2(5), STAT6(1)	10077114	67	51	56	16	21	20	15	4	7	0	0.38	0.95
246	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), APC(9), APC2(2), ARAF(3), ARHGEF1(2), ARHGEF12(3), ARHGEF4(3), ARHGEF6(2), ARHGEF7(3), ARPC1A(2), BCAR1(5), BDKRB1(1), BDKRB2(2), BRAF(7), CD14(1), CDC42(1), CFL1(2), CFL2(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), CYFIP1(4), CYFIP2(6), DIAPH1(1), DIAPH2(1), DIAPH3(5), DOCK1(3), EGF(6), EGFR(6), F2R(2), FGD1(3), FGD3(2), FGF10(2), FGF12(3), FGF14(1), FGF2(2), FGF23(1), FGF3(1), FGF5(2), FGF6(2), FGF8(1), FGFR1(1), FGFR2(3), FGFR3(2), FGFR4(1), FN1(16), GIT1(1), GNA12(1), GNG12(1), GRLF1(11), GSN(2), HRAS(1), IQGAP1(6), IQGAP2(6), IQGAP3(9), ITGA1(3), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGAD(6), ITGAE(3), ITGAL(1), ITGAM(3), ITGAV(3), ITGAX(9), ITGB1(3), ITGB2(3), ITGB3(3), ITGB4(6), ITGB6(1), ITGB7(1), ITGB8(3), KRAS(1), LIMK2(2), MAP2K1(2), MAPK1(1), MAPK3(1), MOS(4), MRAS(2), MSN(3), MYH10(1), MYH14(4), MYH9(12), MYL2(1), MYLK(5), MYLK2(2), MYLPF(1), NCKAP1(4), NCKAP1L(8), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PDGFB(1), PDGFRA(8), PDGFRB(4), PFN2(1), PFN3(1), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(1), PPP1R12B(4), PTK2(4), PXN(3), RAC1(1), RAF1(1), RDX(1), ROCK1(5), ROCK2(3), RRAS2(2), SCIN(1), SLC9A1(3), SOS1(6), SOS2(5), SSH1(1), SSH2(6), TIAM1(8), TIAM2(3), VAV1(7), VAV2(3), VAV3(1), VCL(2), WAS(4), WASL(2)	76078980	478	147	465	136	105	163	100	48	62	0	0.38	0.95
247	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(3)	455858	3	3	3	0	0	2	1	0	0	0	0.39	0.95
248	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(6), AKT1(1), CDC42(1), CFL1(2), CFL2(1), FLNA(8), FLNC(11), FSCN3(1), GDI1(1), GDI2(1), MYH2(21), MYLK(5), MYLK2(2), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PFN2(1), RHO(1), ROCK1(5), ROCK2(3), VASP(2), WASL(2)	13114684	82	62	82	31	17	35	16	5	9	0	0.39	0.95
249	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALML6(1), CDS1(2), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKI(7), DGKZ(3), IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(5), INPP5D(5), INPP5E(2), INPPL1(3), ITPK1(1), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), OCRL(5), PI4KA(4), PI4KB(1), PIK3C2A(4), PIK3C2B(6), PIK3C2G(6), PIK3C3(3), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCD3(1), PLCE1(11), PLCG1(1), PLCG2(3), PLCZ1(4), PRKCA(4), PRKCG(8), PTEN(13), SYNJ1(2), SYNJ2(3)	34411672	231	109	219	56	75	59	45	17	35	0	0.39	0.95
250	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(7), CAP1(2), CCNB1(1), CDC25C(1), GNAI1(2), GNAS(5), GNB1(1), HRAS(1), MAPK1(1), MAPK3(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RPS6KA1(2)	5515508	33	30	33	12	7	11	7	6	2	0	0.39	0.95
251	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12A(1), IL12B(2), IL16(5), IL4(2), LTA(2)	2643656	16	16	16	4	3	4	5	3	1	0	0.39	0.95
252	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(4), ALDH3B2(1), AOC2(1), AOC3(3), DDC(2), EPX(4), GOT2(2), HPD(1), LPO(2), MPO(3), PRDX1(1), PRDX6(1), TAT(1), TPO(10)	5946980	36	33	36	17	10	11	11	4	0	0	0.39	0.95
253	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(4), ADRBK2(1), CALML6(1), CAMK2B(2), CAMK2D(1), CLCA1(4), CLCA2(4), CLCA4(2), CNGA3(3), CNGA4(4), CNGB1(4), GNAL(1), GUCA1A(2), PDE1C(11), PRKACB(2), PRKACG(1), PRKG1(4), PRKG2(3), PRKX(1)	8251724	55	43	55	12	20	16	5	5	9	0	0.39	0.95
254	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	BLVRA(2), CP(2), CPOX(2), EARS2(2), EPRS(10), FECH(2), FTH1(2), FTMT(4), GUSB(2), MMAB(1), PPOX(1), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2), UROD(1)	10816526	66	54	66	14	14	22	19	5	6	0	0.39	0.95
255	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(7), ASH2L(2), CARM1(1), CTCFL(2), DOT1L(4), EED(2), EHMT2(1), EZH1(3), EZH2(4), FBXO11(4), HSF4(1), JMJD6(1), KDM6A(3), MEN1(2), MLL(4), MLL2(34), MLL3(20), MLL4(5), MLL5(3), NSD1(8), OGT(2), PRDM2(4), PRDM9(9), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), RBBP5(1), SATB1(2), SETD1A(6), SETD2(4), SETD8(1), SETDB1(3), SMYD3(1), STK38(4), SUV39H1(1), SUV39H2(2), SUV420H1(1), SUZ12(3), WHSC1(1), WHSC1L1(12)	32840110	176	101	176	42	26	52	39	12	45	2	0.40	0.97
256	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(2), CYP1A2(1), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2J2(1), CYP3A4(1), CYP3A43(3), CYP3A7(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(5), RDH11(1), RDH12(2), RDH13(1)	6442710	42	35	42	13	14	10	8	4	6	0	0.40	0.97
257	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(1), AKT3(2), CASP8(1), CCL3(2), CD14(1), CD40(1), CD80(2), CD86(1), CHUK(2), FADD(1), FOS(1), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IKBKB(2), IKBKE(3), IL12A(1), IL12B(2), IL1B(1), IRAK1(3), IRF3(1), JUN(3), LBP(4), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K7(2), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), RAC1(1), RELA(2), STAT1(2), TBK1(2), TLR1(2), TLR2(3), TLR3(2), TLR4(10), TLR5(2), TLR7(3), TLR8(1), TLR9(1), TOLLIP(1), TRAF3(1), TRAF6(1)	24430500	147	89	134	40	42	41	31	17	16	0	0.41	0.97
258	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG7(4), BECN1(1), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNG(1), PIK3C3(3), PIK3R4(5), PRKAA2(3), ULK1(1), ULK2(2)	5718962	34	30	33	9	10	8	12	1	3	0	0.41	0.97
259	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(1)	506410	3	3	3	0	0	1	1	1	0	0	0.41	0.97
260	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6R(1), JAK1(1), JAK2(3), JAK3(7), PIAS3(2), PTPRU(5), REG1A(11), STAT3(1)	4228924	31	25	31	5	2	17	7	2	3	0	0.41	0.97
261	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(4), ABCC2(4), ABCG2(1), BCHE(9), CES1(2), CES2(1), CYP3A4(1), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1)	6087244	33	33	33	9	7	15	8	2	1	0	0.42	0.98
262	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGT(1), AGTR1(2), AGTR2(3), BDKRB2(2), KNG1(4), NOS3(1)	2766476	17	16	17	10	3	6	4	2	2	0	0.42	0.98
263	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT3(2), BCR(1), BLNK(1), BTK(4), CD19(2), DAG1(1), EPHB2(4), ITPKA(1), ITPKB(4), LYN(1), MAP2K1(2), MAPK1(1), NFAT5(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PI3(1), PIK3CA(20), PIK3CD(3), PIK3R1(1), PLCG2(3), PPP1R13B(4), RAF1(1), SERPINA4(4), SHC1(1), SOS1(6), SOS2(5), SYK(1), VAV1(7)	14332916	94	64	83	22	29	24	20	9	12	0	0.42	0.98
264	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(1), CYP2A6(4), NAT2(1), XDH(8)	2131550	15	13	15	6	4	6	2	1	2	0	0.42	0.98
265	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(2), F13A1(3), F2R(2), FGA(5), FGB(3), FGG(1), PLAT(1), PLAU(2), PLG(1), SERPINB2(3)	3573172	23	21	23	7	3	10	8	0	2	0	0.42	0.98
266	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	GORASP1(1), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MAPKAPK5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PIK3CA(20), PIK3CD(3), PIK3R1(1), SYT1(3), TRAF3(1), TRAF5(2), TRAF6(1)	9355680	59	48	48	11	24	17	7	7	4	0	0.42	0.98
267	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(1), GPR109B(2), GPR161(1), GPR171(2), GPR18(1), GPR34(1), GPR39(1), GPR45(4), GPR65(1), GPR68(1), GPR75(2)	2642232	19	16	19	6	7	7	4	0	1	0	0.43	0.99
268	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(5), GOT2(2), LDHB(2), LDHC(1)	1840164	10	10	10	2	0	3	3	2	2	0	0.43	0.99
269	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(4), FCER1A(2), FOS(1), HRAS(1), JUN(3), LYN(1), MAP2K1(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(2), NFATC2(4), NFATC3(2), NFATC4(1), PIK3CA(20), PIK3R1(1), PLA2G4A(5), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), RAF1(1), SHC1(1), SOS1(6), SYK(1), SYT1(3), VAV1(7)	11633724	81	58	69	20	30	17	16	11	7	0	0.43	0.99
270	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP4(1), BMP5(5), CSNK1A1(2), CSNK1A1L(5), CSNK1G1(2), DHH(1), GLI1(1), GLI2(4), GLI3(6), HHIP(1), IHH(1), LRP2(37), PRKACB(2), PRKACG(1), PRKX(1), PTCH1(4), PTCH2(5), SMO(1), STK36(2), SUFU(2), WNT10B(2), WNT11(1), WNT2(3), WNT2B(2), WNT3(2), WNT3A(1), WNT6(2), WNT7A(2), WNT7B(1), WNT9A(1), WNT9B(1)	16809964	102	73	101	39	30	26	21	14	11	0	0.44	0.99
271	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(2), ABL2(5), AKT1(1), AKT3(2), ARAF(3), AREG(2), BRAF(7), CAMK2B(2), CAMK2D(1), CBL(1), CBLB(4), EGF(6), EGFR(6), ERBB2(1), ERBB3(3), ERBB4(9), EREG(1), GAB1(2), HBEGF(1), HRAS(1), JUN(3), KRAS(1), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MYC(1), NCK1(2), NRG1(3), NRG2(2), NRG3(5), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PRKCA(4), PRKCG(8), PTK2(4), RAF1(1), RPS6KB1(1), SHC1(1), SHC2(2), SHC3(2), SHC4(4), SOS1(6), SOS2(5), STAT5A(2), TGFA(1)	28169390	179	99	166	55	53	57	35	12	22	0	0.44	0.99
272	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREB1(1), CREBBP(12), EP300(6), NCOA3(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RARA(1), RXRA(1)	5467804	34	29	33	10	7	14	4	5	4	0	0.44	0.99
273	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2R(2), F3(1), F5(14), FGA(5), FGB(3), FGG(1), SERPINC1(5)	4394464	34	25	34	7	3	13	13	3	2	0	0.44	1.00
274	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CSAD(1), GAD1(4), GAD2(5), GGT1(1)	1577970	13	10	13	8	4	6	2	1	0	0	0.44	1.00
275	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(2), BCR(1), BLNK(1), FOS(1), HRAS(1), JUN(3), LYN(1), MAP2K1(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8IP3(3), PAPPA(8), RAC1(1), RPS6KA1(2), RPS6KA3(1), SHC1(1), SOS1(6), SYK(1), VAV1(7), VAV2(3), VAV3(1)	8747988	50	44	49	10	10	14	16	6	4	0	0.45	1.00
276	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(7), CREB1(1), CREB3(2), CREB5(3), MAPK1(1), RAF1(1), SNX13(4)	3132622	19	18	19	6	5	3	8	0	3	0	0.45	1.00
277	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(5), CHIT1(4), CMAS(2), CTBS(4), CYB5R1(1), GFPT2(1), GNE(2), GNPDA2(3), HEXA(4), HK1(3), HK2(5), HK3(5), MTMR1(1), MTMR2(1), MTMR6(4), UAP1(1)	7756350	47	38	47	13	11	16	9	3	8	0	0.45	1.00
278	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(6), COL4A2(6), COL4A3(5), COL4A4(9), COL4A5(2), COL4A6(6), SLC23A1(1), SLC23A2(2), SLC2A3(2)	6862612	39	35	39	10	12	17	4	1	5	0	0.45	1.00
279	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACPT(1), ENPP1(7), ENPP3(3), FLAD1(1), TYR(3)	2593104	16	15	16	5	3	9	2	0	2	0	0.46	1.00
280	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(1), MTMR6(4), NFS1(2), TPK1(3)	1721082	11	11	11	1	1	4	5	0	1	0	0.47	1.00
281	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT1(1), FBP2(1), G6PC(2), GALK2(1), GALT(1), GANAB(5), GCK(1), GLA(2), HK1(3), HK2(5), HK3(5), LCT(14), MGAM(3), PFKM(4), PFKP(2)	8911570	50	45	50	20	17	17	6	7	3	0	0.47	1.00
282	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP6(2), ACPT(1), ENPP1(7), ENPP3(3), FLAD1(1), MTMR1(1), MTMR2(1), MTMR6(4), TYR(3)	4031522	24	22	24	7	4	10	5	0	5	0	0.47	1.00
283	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(1), HRAS(1), JUN(3), MAP2K1(2), MAPK1(1), MAPK3(1), MYC(1), NFKB1(2), PLCB1(6), PRKCA(4), RAF1(1), RELA(2)	4191188	27	23	26	7	9	7	3	6	2	0	0.47	1.00
284	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(2), GSS(2), NFKB1(2), NOX1(2), RELA(2), XDH(8)	2705600	18	14	18	2	4	5	2	4	3	0	0.47	1.00
285	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(1), UGDH(2), UXS1(3)	1073162	7	6	7	0	0	3	2	1	1	0	0.48	1.00
286	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(2), ABP1(4), ACADL(2), ACADM(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), AOC2(1), AOC3(3), CNDP1(3), DPYD(7), DPYS(4), GAD1(4), GAD2(5), HADHA(2), MLYCD(1), SDS(2), SMS(2)	7843214	51	40	51	17	14	20	8	5	4	0	0.49	1.00
287	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(1), AOC3(3), CES1(2)	1611612	10	9	10	5	4	2	2	2	0	0	0.49	1.00
288	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(1), ACADS(2), ACAT1(1), HADHA(2)	1468678	8	8	8	1	2	2	1	1	2	0	0.49	1.00
289	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(1), IFNG(1), IL4(2), TGFB1(1), TGFB2(2), TGFBR2(3), TGFBR3(6)	2875946	16	16	16	7	0	7	6	0	3	0	0.49	1.00
290	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(4), ADC(1), ALDH18A1(3), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), AMD1(1), AOC2(1), AOC3(3), ARG1(2), ASL(3), CPS1(18), GATM(1), NAGS(1), ODC1(1), OTC(2), SMS(2)	8031894	50	40	49	9	18	15	10	3	4	0	0.49	1.00
291	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CALR(1), CANX(1), CD4(1), CD8B(1), CIITA(3), CREB1(1), CTSL1(1), CTSS(2), HLA-A(7), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-G(1), HSP90AB1(2), HSPA5(3), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), KIR2DL1(1), KIR2DL3(4), KIR2DS4(5), KIR3DL1(6), KIR3DL2(1), KIR3DL3(1), KLRC1(1), KLRC3(1), LTA(2), NFYB(1), PSME2(1), TAP1(2), TAPBP(3)	12697808	76	51	74	31	8	22	22	8	14	2	0.50	1.00
292	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(2), ABP1(4), ACADM(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), AOC2(1), AOC3(3), CNDP1(3), DPYD(7), DPYS(4), GAD1(4), GAD2(5), HADHA(2), HIBCH(1), MLYCD(1), SMS(2)	7313308	47	37	47	16	15	17	6	5	4	0	0.50	1.00
293	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(2), MMP2(3), MMP9(4), RECK(3), TIMP2(1)	2030980	14	11	14	3	2	6	3	2	1	0	0.50	1.00
294	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(5), DARS(1), EPRS(10), FARS2(1), HARS(2), IARS(3), KARS(2), LARS2(3), MARS(1), NARS(2), RARS(4), SARS(2), TARS(3), WARS(3), WARS2(1), YARS(1)	8565716	45	42	45	12	6	15	17	2	5	0	0.51	1.00
295	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(1), DIAPH1(1), FYN(3), GSN(2), HRAS(1), ITGA1(3), ITGB1(3), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(5), PIK3CA(20), PIK3R1(1), PTK2(4), PXN(3), RAF1(1), ROCK1(5), SHC1(1), TLN1(3)	10127488	62	52	51	12	23	15	12	9	3	0	0.51	1.00
296	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(2), CHAT(2), DBH(1), DDC(2), GAD1(4), GAD2(5), HDC(3), PAH(1), PNMT(2), TH(1), TPH1(1)	3978300	24	22	24	9	8	10	4	1	1	0	0.51	1.00
297	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(2), LDLR(3), LPL(3)	1424534	9	9	9	2	5	3	1	0	0	0	0.52	1.00
298	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(11), RANGAP1(4)	2248318	15	13	15	5	2	6	3	2	2	0	0.52	1.00
299	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(2), CHKA(2), PDHA1(2), PDHA2(5)	1926672	13	12	13	2	3	6	3	1	0	0	0.52	1.00
300	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(2), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(2), GAPDH(2), GAPDHS(1), GCK(1), GOT2(2), GPI(5), HK1(3), HK2(5), HK3(5), LDHAL6B(1), LDHB(2), LDHC(1), MDH1(1), MDH2(1), PC(2), PCK1(1), PDHA1(2), PDHA2(5), PFKL(2), PFKM(4), PFKP(2), PGAM2(1), PGK1(1), PGK2(4), PKLR(3), PKM2(2), TPI1(3)	11286268	73	54	73	25	19	28	13	6	7	0	0.52	1.00
301	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), FDXR(2)	4317924	21	20	21	7	5	3	7	1	5	0	0.52	1.00
302	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(3), E2F1(2), ETS1(2), ETV3(2), FOS(1), HDAC5(1), HRAS(1), JUN(3), NCOR2(6), RBL1(5), RBL2(5), SIN3A(5), SIN3B(3)	7269342	41	36	40	9	7	15	8	7	4	0	0.53	1.00
303	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(15), ABCB11(5), ABCB4(6), ABCC1(4), ABCC3(1)	3890190	31	22	31	8	10	9	8	2	0	2	0.54	1.00
304	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	146	AKT1(1), AKT3(2), BCL2L1(1), CBL(1), CBLB(4), CCND2(3), CCND3(1), CNTFR(1), CREBBP(12), CSF2RB(5), CSF3R(5), EP300(6), EPOR(2), GH2(2), GHR(2), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), IL10(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL13RA2(1), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL22RA2(1), IL23R(1), IL28B(1), IL2RB(2), IL2RG(1), IL4(2), IL4R(1), IL5RA(2), IL6R(1), IL7R(2), JAK1(1), JAK2(3), JAK3(7), LEPR(10), LIFR(2), MPL(2), MYC(1), OSMR(2), PIAS1(2), PIAS3(2), PIAS4(2), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIM1(2), PRL(1), PRLR(5), PTPN11(2), SOCS2(1), SOCS5(3), SOS1(6), SOS2(5), SPRED1(1), SPRED2(1), STAM(1), STAM2(2), STAT1(2), STAT2(1), STAT3(1), STAT4(4), STAT5A(2), STAT6(1), TPO(10), TYK2(5)	38399228	232	115	219	85	57	79	53	21	22	0	0.54	1.00
305	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(1), ACACB(8), AKT1(1), AKT3(2), ARAF(3), BRAF(7), CALML6(1), CBL(1), CBLB(4), EXOC7(1), FBP2(1), FLOT1(1), G6PC(2), G6PC2(1), GCK(1), GYS1(1), GYS2(4), HRAS(1), IKBKB(2), INPP5D(5), INSR(7), IRS1(3), IRS2(2), IRS4(2), KRAS(1), LIPE(1), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MKNK2(1), PCK1(1), PCK2(1), PDE3A(4), PDE3B(3), PDPK1(1), PFKL(2), PFKM(4), PFKP(2), PHKA1(4), PHKA2(2), PHKB(6), PHKG1(2), PHKG2(1), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PKLR(3), PKM2(2), PPARGC1A(5), PPP1R3A(12), PPP1R3C(2), PPP1R3D(2), PRKAA2(3), PRKACB(2), PRKACG(1), PRKAG2(4), PRKAG3(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCI(4), PRKX(1), PTPN1(1), PTPRF(6), PYGB(3), PYGM(4), RAF1(1), RAPGEF1(3), RPS6(1), RPS6KB1(1), SHC1(1), SHC2(2), SHC3(2), SHC4(4), SLC2A4(2), SOCS2(1), SORBS1(5), SOS1(6), SOS2(5), SREBF1(2), TRIP10(2), TSC1(5), TSC2(5)	44062120	258	120	247	82	70	86	54	17	31	0	0.55	1.00
306	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(2), CP(2), CPOX(2), EPRS(10), FECH(2), GUSB(2), PPOX(1), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2B15(1), UGT2B4(4), UROD(1)	7022990	38	35	38	9	6	14	13	2	3	0	0.55	1.00
307	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(1), GLI2(4), GLI3(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), SMO(1), SUFU(2)	4465486	25	23	25	12	4	11	4	3	3	0	0.55	1.00
308	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	CEBPA(1), CHUK(2), DAXX(2), EGF(6), EGFR(6), ETS1(2), FOS(1), HOXA7(2), HRAS(1), IKBKB(2), JUN(3), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K14(1), MAP3K5(3), MAPK1(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCQ(4), RAF1(1), RELA(2), SP1(1), TNFRSF1A(2), TNFRSF1B(1)	13433838	77	60	75	17	23	24	14	6	10	0	0.55	1.00
309	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), CD4(1), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL4(2), IL5RA(2)	1438952	9	8	9	2	1	4	1	0	3	0	0.55	1.00
310	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(5), IL4(2), MAF(1), MAP2K3(2), MAPK14(1), NFATC2(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	3260782	23	19	23	6	10	7	3	1	2	0	0.56	1.00
311	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(1), CDK7(1), CHEK1(4), NEK1(3), WEE1(2)	1979716	11	11	11	1	3	5	2	0	1	0	0.56	1.00
312	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(6), GGT1(1)	1181208	7	6	7	4	1	2	3	0	1	0	0.56	1.00
313	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(2), APOA2(1), CD36(1), CREBBP(12), EP300(6), HSD17B4(1), JUN(3), LPL(3), MAPK1(1), MAPK3(1), MYC(1), NCOA1(5), NCOR1(5), NCOR2(6), NR0B2(1), NR1H3(2), NRIP1(3), PIK3CA(20), PIK3R1(1), PPARA(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), RB1(7), RELA(2), RXRA(1), SP1(1), STAT5A(2)	16962866	101	70	88	35	30	30	17	9	15	0	0.56	1.00
314	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(5), AMY2B(3), ASCC3(9), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(1), DDX41(2), DDX50(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENPP1(7), ENPP3(3), ENTPD7(1), ERCC3(1), G6PC(2), G6PC2(1), GANC(3), GBA3(6), GBE1(1), GCK(1), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(3), HK2(5), HK3(5), IFIH1(3), MGAM(3), NUDT8(1), PYGB(3), PYGM(4), RAD54L(1), SETX(10), SI(31), SKIV2L2(2), SMARCA2(2), TREH(1), UGDH(2), UGP2(4), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2), UXS1(3)	33165672	190	102	190	50	51	64	47	12	16	0	0.57	1.00
315	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(6), GNAS(5), GNB1(1), HRAS(1), ITGB1(3), KLK2(1), MAP2K1(2), MAPK1(1), MAPK3(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(8), PTPRR(7), RAF1(1), RPS6KA1(2), RPS6KA5(4), SHC1(1), SOS1(6), STAT3(1)	9071948	54	45	53	12	16	12	19	5	2	0	0.57	1.00
316	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(5), AR(4), ESR1(5), ESR2(1), HNF4A(2), NR0B1(4), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(3), NR2F6(1), NR4A1(4), NR4A2(3), NR5A2(4), PGR(3), PPARA(1), PPARD(1), RARA(1), RARB(2), RARG(1), ROR1(3), RORA(2), RORC(2), RXRA(1), RXRG(4), THRA(1), THRB(1), VDR(3)	11522474	67	52	67	21	19	20	14	4	10	0	0.57	1.00
317	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3)	4058222	19	18	19	7	4	2	7	1	5	0	0.58	1.00
318	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3)	4058222	19	18	19	7	4	2	7	1	5	0	0.58	1.00
319	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3)	4058222	19	18	19	7	4	2	7	1	5	0	0.58	1.00
320	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(4), DLG4(1), EPHB2(4), F2RL1(3), F2RL2(1), F2RL3(1), JUN(3), MAP2K5(1), MAPK1(1), MAPK7(1), MAPK8(2), MYEF2(3), PLD1(6), PLD2(2), PLD3(1), PTK2(4), RAF1(1), RASAL1(3), TEC(2), VAV1(7)	7510888	51	37	50	16	13	17	11	4	6	0	0.58	1.00
321	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	16	CXCR4(5), FOS(1), JUN(3), MAPK14(1), MAPK8(2), PLCG1(1), PRKCA(4), SYT1(3)	3539708	20	19	19	8	7	5	4	3	1	0	0.59	1.00
322	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(1), GRIA2(3), PPP1R1B(1)	1061414	5	5	5	5	0	2	1	0	2	0	0.59	1.00
323	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(2), ATF2(2), EGFR(6), HRAS(1), JUN(3), MAP2K1(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(2), MEF2C(3), MEF2D(2), PAK1(1), PRKCA(4), PTK2(4), RAC1(1), RAF1(1), SHC1(1), SOS1(6), SYT1(3)	9123746	51	46	49	18	16	13	12	6	4	0	0.59	1.00
324	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	31	GTF2A1(1), GTF2B(1), GTF2E1(1), GTF2F1(1), GTF2H4(1), GTF2I(1), GTF2IRD1(4), TAF1(10), TAF1L(16), TAF2(6), TAF4(1), TAF4B(4), TAF5L(1), TAF6L(1), TAF7L(1), TAF9(2), TBPL2(1)	9710434	53	46	53	13	15	16	10	6	6	0	0.59	1.00
325	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(2), CREBBP(12), EP300(6), FADD(1), HDAC3(1), IKBKB(2), NFKB1(2), RELA(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1)	6117860	33	28	32	9	7	9	6	4	7	0	0.60	1.00
326	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	246	ACVR1B(3), ACVR2A(3), AMHR2(4), BMPR1A(3), CCL14(2), CCL16(1), CCL20(1), CCL26(2), CCL3(2), CCR1(2), CCR3(1), CCR4(3), CCR6(2), CCR8(1), CD27(1), CD40(1), CD40LG(2), CNTFR(1), CSF1(2), CSF1R(3), CSF2RB(5), CSF3R(5), CX3CR1(3), CXCL5(2), CXCR3(1), CXCR4(5), EDA2R(1), EGF(6), EGFR(6), EPOR(2), FAS(1), FASLG(1), FLT1(8), FLT3(4), FLT4(3), GDF5(4), GH2(2), GHR(2), HGF(6), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), IL10(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL17A(1), IL17RA(3), IL18R1(2), IL18RAP(2), IL1B(1), IL1R2(3), IL1RAP(2), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL22RA2(1), IL23R(1), IL28B(1), IL2RB(2), IL2RG(1), IL4(2), IL4R(1), IL5RA(2), IL6R(1), IL7R(2), INHBA(4), INHBC(1), KDR(12), KIT(5), LEPR(10), LIFR(2), LTA(2), LTBR(1), MET(3), MPL(2), NGFR(1), OSMR(2), PDGFB(1), PDGFC(1), PDGFRA(8), PDGFRB(4), PF4(1), PLEKHO2(3), PRL(1), PRLR(5), TGFB1(1), TGFB2(2), TGFBR2(3), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(1), TNFRSF11B(1), TNFRSF13B(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF6B(1), TNFRSF9(1), TNFSF11(1), TNFSF13(1), TNFSF14(1), TNFSF18(1), TPO(10), VEGFC(4), XCL1(1), XCR1(1)	47276444	282	124	280	111	74	99	56	19	34	0	0.60	1.00
327	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(1), HLA-DRA(1), HLA-DRB1(1)	650412	3	3	3	2	0	1	0	0	2	0	0.60	1.00
328	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(2), FBP2(1), GOT2(2), GPT(1), GPT2(2), MDH1(1), MDH2(1), ME2(2), ME3(1), PGK1(1), PKLR(3), PKM2(2), RPIA(1), TKT(1), TPI1(3)	4743700	25	24	25	13	5	7	6	3	4	0	0.60	1.00
329	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), BCR(1), FOS(1), HRAS(1), JAK2(3), JUN(3), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8(2), MYC(1), PIK3CA(20), PIK3R1(1), RAF1(1), SOS1(6), STAT1(2), STAT5A(2)	7564110	50	40	38	7	20	11	13	4	2	0	0.60	1.00
330	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(5), GOT2(2), LDHAL6B(1), LDHB(2), LDHC(1), SDS(2), SULT1B1(4), SULT1C2(3), SULT1C4(1)	3393748	21	18	21	4	2	9	6	2	2	0	0.61	1.00
331	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(2), ADSL(1), ADSS(1), AGXT2(1), ASL(3), ASNS(3), CAD(8), DARS(1), DDO(2), GAD1(4), GAD2(5), GOT2(2), GPT(1), GPT2(2), NARS(2), PC(2)	7056632	41	34	41	16	7	20	8	3	3	0	0.62	1.00
332	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL4(2), ST3GAL5(2), ST8SIA1(2)	1506770	8	8	8	6	2	2	3	0	1	0	0.62	1.00
333	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(1), CAMK1G(2), HDAC5(1), IGF1(3), INSR(7), MAP2K6(2), MAPK14(1), MAPK7(1), MEF2A(2), MEF2C(3), MEF2D(2), NFATC2(4), PIK3CA(20), PIK3R1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), SYT1(3)	9507870	62	46	51	15	23	16	11	8	4	0	0.62	1.00
334	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(2), FADD(1), IKBKB(2), IRAK1(3), MAP3K1(2), MAP3K14(1), MAP3K7(2), NFKB1(2), RELA(2), TLR4(10), TNFAIP3(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1)	6703836	35	29	35	14	8	8	7	5	7	0	0.62	1.00
335	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(2), ACAD9(3), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(4), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(3), HADHB(2), LIPA(2), RDH11(1), RDH12(2), RDH13(1), SLC27A5(4), SOAT2(1), SRD5A1(2), SRD5A2(2)	8668778	50	42	50	12	12	19	6	7	6	0	0.63	1.00
336	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(9), ATF2(2), BMP10(1), BMP4(1), BMP5(5), BMPR1A(3), CHRD(3), CTNNB1(3), DVL1(3), FZD1(1), MAP3K7(2), MEF2C(3), MYL2(1), NKX2-5(2), RFC1(1), TGFB1(1), TGFB2(2), TGFBR2(3), TGFBR3(6)	9785906	52	44	52	14	10	15	14	6	7	0	0.63	1.00
337	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CUL1(2), E2F1(2), RB1(7), SKP2(1)	2358678	12	11	12	1	1	6	0	0	5	0	0.63	1.00
338	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(3), PRKCA(4)	1368286	7	7	7	1	2	1	3	0	1	0	0.63	1.00
339	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12A(1), IL12B(2), IL4(2), LTA(2), TGFB1(1), TGFB2(2)	3596846	19	18	19	6	2	6	5	3	3	0	0.64	1.00
340	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(1), AKT3(2), CARD11(3), CBL(1), CBLB(4), CD3D(1), CD4(1), CD40LG(2), CD8B(1), CDC42(1), CHP(2), CHUK(2), FOS(1), FYN(3), HRAS(1), ICOS(2), IFNG(1), IKBKB(2), IL10(1), IL4(2), ITK(2), JUN(3), KRAS(1), LCK(2), LCP2(2), MALT1(1), MAP3K14(1), NCK1(2), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB1(2), NFKB2(2), NFKBIB(1), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PDK1(1), PIK3CA(20), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKCQ(4), PTPRC(3), RASGRP1(1), SOS1(6), SOS2(5), TEC(2), VAV1(7), VAV2(3), VAV3(1), ZAP70(2)	27660132	159	92	147	45	44	43	32	20	20	0	0.64	1.00
341	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	AKT1(1), DAG1(1), DGKA(3), ETFA(2), GCA(1), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), MAP2K1(2), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(1), PDE3A(4), PDE3B(3), PI3(1), PIK3C2G(6), PIK3CA(20), PIK3CD(3), PIK3R1(1), RIPK3(1), SGCB(1), VASP(2)	13431346	77	59	66	20	32	19	15	3	8	0	0.64	1.00
342	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), PLCB1(6), PRKCA(4), RELA(2)	2235858	14	11	14	4	5	4	1	2	2	0	0.64	1.00
343	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), ACO2(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SUCLA2(2)	2378792	12	12	12	3	2	6	1	2	1	0	0.64	1.00
344	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(3), GRHPR(1), HAO1(5), MDH1(1), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3)	3428992	20	18	20	2	6	6	5	2	1	0	0.65	1.00
345	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT3(1), AGPAT6(1), ENPP2(6), ENPP6(1), PAFAH1B1(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(5), PLD1(6), PLD2(2), PPAP2B(1)	6299776	38	31	38	18	7	17	8	1	5	0	0.65	1.00
346	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(2), TAT(1)	702744	3	3	3	2	1	1	0	1	0	0	0.65	1.00
347	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(1), B4GALT1(1), B4GALT3(1), B4GALT4(1), CHST1(2), CHST2(3), CHST4(2), CHST6(3), FUT8(2), ST3GAL1(1), ST3GAL4(2)	3427212	20	18	20	10	8	6	4	2	0	0	0.65	1.00
348	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(1), GGPS1(2), IDI1(1), IDI2(2), SQLE(2)	1174622	8	7	8	0	3	2	1	2	0	0	0.65	1.00
349	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), BRAF(7), CREB1(1), CREB3(2), CREB5(3), CREBBP(12), DAG1(1), EGR1(2), EGR2(6), EGR3(1), FRS2(3), JUN(3), MAP1B(3), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), NTRK1(3), OPN1LW(2), PIK3C2G(6), PIK3CA(20), PIK3CD(3), PIK3R1(1), PTPN11(2), RPS6KA3(1), SHC1(1), TH(1)	14262962	96	63	84	29	37	29	18	6	6	0	0.66	1.00
350	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(5), CRY1(1), CRY2(2), PER1(4)	2337496	14	12	14	3	0	5	7	1	1	0	0.66	1.00
351	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(3), MBTPS1(3), MBTPS2(3), SCAP(4), SREBF1(2), SREBF2(2)	3331092	18	17	18	3	5	5	4	4	0	0	0.66	1.00
352	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2A(1), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2E3(1), UBE2G2(1), UBE2J1(2), UBE2L6(1), UBE2M(1), UBE3A(5)	2847644	15	15	15	4	4	6	2	1	2	0	0.66	1.00
353	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), DLAT(1), DLD(2), DLST(1), FH(2), IDH3A(1), IDH3B(3), IDH3G(1), MDH1(1), MDH2(1), OGDH(3), PC(2), PDHA1(2), PDHA2(5), PDK1(1), PDK2(1), PDK3(2), PDK4(2), PDP2(4), SDHA(1), SUCLA2(2), SUCLG2(1)	7678564	42	37	42	12	5	17	7	8	5	0	0.66	1.00
354	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	B4GALT1(1), G6PC(2), G6PC2(1), GALK2(1), GALT(1), GANC(3), GCK(1), GLA(2), HK1(3), HK2(5), HK3(5), LCT(14), MGAM(3), PFKL(2), PFKM(4), PFKP(2), RDH11(1), RDH12(2), RDH13(1), UGP2(4)	10583880	58	49	58	21	22	14	8	9	5	0	0.66	1.00
355	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(4), ATP4A(6), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5G2(2), ATP5G3(1), ATP5L(1), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), COX4I1(1), COX4I2(1), COX6B1(1), COX7B2(2), CYC1(4), NDUFA13(2), NDUFA7(1), NDUFAB1(1), NDUFB5(2), NDUFB8(1), NDUFS1(3), NDUFS6(1), NDUFS8(1), NDUFV1(2), NDUFV2(2), SDHA(1), UQCRB(1), UQCRC2(1)	15113624	74	59	74	21	12	24	22	7	9	0	0.68	1.00
356	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(5), GCLC(2), GCLM(1), GGT1(1), GPX5(1), GPX6(2), GSR(2), GSS(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(3), GSTM5(2), GSTZ1(2), IDH1(2), MGST1(1), OPLAH(3)	6086710	33	30	33	10	7	15	7	3	1	0	0.68	1.00
357	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACPT(1), ALPL(3), ALPP(2), ALPPL2(1), CYP19A1(4), CYP1A1(7), CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2B6(3), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(2), CYP4F8(1), PON1(4)	7937020	54	38	54	26	16	15	15	4	4	0	0.68	1.00
358	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(7), ADCY2(14), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), CALML6(1), CAMK2B(2), CAMK2D(1), CREB1(1), CREB3(2), CREB3L2(2), CREB3L3(1), CREB3L4(2), CREBBP(12), CTNNB1(3), DCT(1), DVL1(3), DVL3(2), EDNRB(3), EP300(6), FZD1(1), FZD10(1), FZD3(4), FZD4(1), FZD6(2), FZD7(1), FZD9(2), GNAI1(2), GNAI3(1), GNAS(5), HRAS(1), KIT(5), KRAS(1), LEF1(3), MAP2K1(2), MAPK1(1), MAPK3(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), POMC(1), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), RAF1(1), TCF7(1), TYR(3), TYRP1(2), WNT10B(2), WNT11(1), WNT2(3), WNT2B(2), WNT3(2), WNT3A(1), WNT6(2), WNT7A(2), WNT7B(1), WNT9A(1), WNT9B(1)	29895100	185	97	184	58	52	62	32	22	17	0	0.68	1.00
359	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	303668	1	1	1	0	0	1	0	0	0	0	0.68	1.00
360	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(1), EXTL1(1), EXTL3(1), HS3ST2(1), HS3ST5(4), HS6ST1(2), HS6ST3(2), NDST1(2), NDST2(1), NDST3(4), NDST4(11)	5722344	32	28	32	13	2	15	7	6	2	0	0.68	1.00
361	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(5), CKM(2), FBL(1), GPT(1), LDHB(2), LDHC(1), MAPK14(1), NCL(1)	2415104	14	12	14	4	2	7	2	1	2	0	0.70	1.00
362	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT3(2), BRAF(7), DAG1(1), DRD2(2), EGFR(6), EPHB2(4), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), KCNJ3(7), KCNJ5(2), KCNJ9(2), MAPK1(1), PI3(1), PIK3CB(2), PITX2(3), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), RAF1(1), RGS20(1), SHC1(1), SOS1(6), SOS2(5), STAT3(1)	16020534	95	66	94	21	24	31	21	5	14	0	0.70	1.00
363	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ABP1(4), ACAT1(1), ACMSD(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), AOC2(1), AOC3(3), AOX1(9), CYP19A1(4), CYP1A1(7), CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2B6(3), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(2), CYP4F8(1), DDC(2), GCDH(1), HADHA(2), KMO(2), KYNU(3), SDS(2), TDO2(1), TPH1(1), WARS(3), WARS2(1)	14696748	87	63	87	39	23	29	21	8	6	0	0.70	1.00
364	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), GCK(1), GNE(2), GNPDA2(3), HEXA(4), HK1(3), HK2(5), HK3(5), UAP1(1)	4584390	26	22	26	7	7	9	3	3	4	0	0.70	1.00
365	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CD44(3), CSF1(2), FCGR3A(3), IL1B(1), IL6R(1), SELL(2), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(1)	3779118	22	18	22	8	6	6	5	2	3	0	0.70	1.00
366	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), EGR1(2), HRAS(1), KLK2(1), MAP2K1(2), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1)	2270034	11	11	11	3	2	6	2	1	0	0	0.71	1.00
367	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(3), GRHPR(1), HAO1(5), MDH1(1), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3)	3592396	20	18	20	2	6	6	5	2	1	0	0.72	1.00
368	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(1), GTF2B(1), GTF2E1(1), GTF2F1(1), HDAC3(1), NCOA1(5), NCOA2(9), NCOA3(4), NCOR2(6), POLR2A(1), RARA(1), RXRA(1), TBP(1)	6895008	34	30	34	13	8	12	5	2	7	0	0.72	1.00
369	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(2), FLT3(4), IGF1(3), TGFB1(1), TGFB2(2)	2290504	12	12	12	9	2	6	4	0	0	0	0.72	1.00
370	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), HLA-DRA(1), HLA-DRB1(1)	817376	3	3	3	0	0	1	0	0	2	0	0.72	1.00
371	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(1), AKR1C4(1), ALDH3B2(1), CYP1A1(7), CYP1A2(1), CYP2B6(3), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2F1(3), CYP2S1(1), CYP3A4(1), CYP3A43(3), CYP3A7(1), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(3), GSTM5(2), GSTZ1(2), MGST1(1), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2)	14907500	89	63	89	33	24	25	26	8	6	0	0.73	1.00
372	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(7), CREB1(1), FOS(1), GNAI1(2), GNAS(5), GNB1(1), HRAS(1), JUN(3), MAP2K1(2), MAPK3(1), NFATC2(4), NFATC3(2), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), RAF1(1), RPS6KA3(1), SYT1(3)	9434534	57	43	56	14	18	17	7	10	5	0	0.73	1.00
373	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(2), GAPDH(2), GCK(1), GPI(5), HK1(3), HK2(5), HK3(5), LDHB(2), LDHC(1), PDHA1(2), PDHA2(5), PFKM(4), PFKP(2), PGK1(1), PKLR(3), PKM2(2), TPI1(3)	12973530	74	59	74	19	20	31	14	6	3	0	0.73	1.00
374	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(2), GAPDH(2), GCK(1), GPI(5), HK1(3), HK2(5), HK3(5), LDHB(2), LDHC(1), PDHA1(2), PDHA2(5), PFKM(4), PFKP(2), PGK1(1), PKLR(3), PKM2(2), TPI1(3)	12973530	74	59	74	19	20	31	14	6	3	0	0.73	1.00
375	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(12), EP300(6), IKBKB(2), IL1B(1), MAP2K3(2), MAP2K6(2), MAP3K14(1), MAP3K7(2), MAPK14(1), NFKB1(2), RELA(2), TGFBR2(3), TLR2(3)	8069630	41	36	40	11	10	12	8	3	8	0	0.73	1.00
376	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(1), CPT1A(3), LEPR(10), PRKAA2(3), PRKAG2(4)	3886986	21	20	21	6	8	5	6	1	1	0	0.74	1.00
377	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(2), DERA(1), FBP2(1), GPI(5), H6PD(2), PFKL(2), PFKM(4), PFKP(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RBKS(1), RPIA(1), TALDO1(1), TKT(1), TKTL2(9)	6647588	36	31	36	14	9	10	8	4	5	0	0.74	1.00
378	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS2(1), PON1(4), PON2(1), PON3(1), RDH11(1), RDH12(2), RDH13(1)	2268076	11	11	11	3	3	3	1	2	2	0	0.74	1.00
379	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT9(1), GBGT1(2), GLA(2), HEXA(4), ST3GAL1(1), ST3GAL4(2), ST8SIA1(2)	2748498	14	12	14	5	2	5	4	2	1	0	0.74	1.00
380	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), AZIN1(1), BTG1(1), CLOCK(5), CRY1(1), CRY2(2), EIF4G2(2), ETV6(4), GSTM3(1), HERPUD1(1), HSPA8(3), IDI1(1), KLF9(1), MYF6(1), NCKAP1(4), PER1(4), PER2(2), PIGF(1), PPP1R3C(2), PSMA4(1), PURA(1), SF3A3(2), UCP3(3), UGP2(4), VAPA(1), ZFR(4)	9949310	55	43	55	13	7	18	17	4	9	0	0.74	1.00
381	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(1), CD3D(1), DAG1(1), EPHB2(4), FBXW7(10), ITK(2), ITPKA(1), ITPKB(4), LCK(2), LCP2(2), MAPK1(1), NCK1(2), NFAT5(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PLCG1(1), PTPRC(3), RAF1(1), RASGRP1(1), RASGRP3(6), RASGRP4(4), SOS1(6), SOS2(5), VAV1(7), ZAP70(2)	15279876	86	62	84	31	21	25	20	6	14	0	0.74	1.00
382	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(3), JAK3(7), MAPK1(1), MAPK3(1), STAT3(1), TYK2(5)	3262918	19	16	19	3	2	10	5	1	1	0	0.74	1.00
383	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS2(1), SULT1A2(2), SULT1E1(1), SULT2A1(3)	1626208	8	8	8	3	2	3	2	0	1	0	0.74	1.00
384	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(4), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(3), HADHB(2), SOAT2(1), SRD5A1(2), SRD5A2(2)	6312592	35	30	35	8	7	15	6	4	3	0	0.74	1.00
385	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2R(2), F2RL3(1), GNAI1(2), GNB1(1), HRAS(1), ITGA1(3), ITGB1(3), MAP2K1(2), MAPK1(1), MAPK3(1), PLA2G4A(5), PLCB1(6), PRKCA(4), PTGS1(2), PTK2(4), RAF1(1), SYK(1), TBXAS1(2)	6603266	42	32	42	12	13	15	7	3	4	0	0.75	1.00
386	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(4), FOS(1), HRAS(1), JUN(3), LYN(1), MAP2K1(2), MAP3K1(2), MAPK14(1), MAPK3(1), MAPK8(2), NFATC2(4), NFATC3(2), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKCA(4), RAC1(1), RAF1(1), SHC1(1), SOS1(6), SYK(1), SYT1(3), VAV1(7)	10354616	59	46	58	12	18	12	12	10	7	0	0.75	1.00
387	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(4), ALDH3B2(1), AOC2(1), AOC3(3), DDC(2), EPX(4), ESCO1(1), GOT2(2), HPD(1), LPO(2), MPO(3), MYST3(9), MYST4(3), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(1), TPO(10)	9222714	50	42	50	23	12	17	13	5	3	0	0.75	1.00
388	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGA4(3), ITGAL(1), ITGAM(3), ITGB1(3), ITGB2(3), SELE(4), SELL(2), SELP(8)	4718780	32	23	32	7	8	9	9	2	4	0	0.75	1.00
389	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT2(2), COASY(2), DPYD(7), DPYS(4), ENPP1(7), ENPP3(3), ILVBL(2), PANK3(1), PPCS(1), VNN1(2)	4731952	31	23	31	9	10	9	7	2	3	0	0.76	1.00
390	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), CBS(4), MUT(1)	1333932	7	6	7	0	0	5	0	0	2	0	0.76	1.00
391	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2)	1501074	7	7	7	2	3	4	0	0	0	0	0.76	1.00
392	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(2), FUT3(3), ST3GAL4(2)	1955330	9	9	9	4	3	0	5	1	0	0	0.76	1.00
393	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(2), FOS(1), JUN(3), MAPK3(1), POLR2A(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	3384492	17	16	16	5	5	6	1	2	3	0	0.76	1.00
394	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(19), B3GALT4(1), CDR1(2), DGKI(7), MRPL19(1), PIGK(1), RPL14(1), RPL19(1), RPL32(1), RPL37(1), RPL3L(1), RPL4(1), RPL5(1), RPL7(1), RPL8(2), RPLP0(2), RPS11(1), RPS18(1), RPS2(1), RPS21(1), RPS26(1), RPS6(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA6(4), RPS6KB1(1), RPS8(1), SLC36A2(2), TBC1D10C(1), TSPAN9(1), UBB(1), UBC(1)	14395750	67	58	67	31	15	15	24	11	2	0	0.76	1.00
395	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1), CFL1(2), CFLAR(1)	1038452	4	4	4	1	0	3	0	0	1	0	0.76	1.00
396	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), FH(2), MDH1(1), OGDH(3), SDHA(1), SUCLA2(2)	2517098	12	12	12	6	1	5	2	3	1	0	0.76	1.00
397	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(2), CAPNS2(1), CDK5(1), CSNK1A1(2), MAPT(4)	2580466	11	11	11	1	1	5	0	1	4	0	0.77	1.00
398	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT3(2), APC(9), CSNK1A1(2), CTNNB1(3), DACT1(3), DKK1(3), DKK2(1), DVL1(3), FSTL1(2), GSK3A(3), LRP1(10), MVP(2), NKD1(1), NKD2(2), PSEN1(1), SENP2(3), SFRP1(1), WIF1(3)	10938100	55	46	55	15	15	16	13	2	9	0	0.77	1.00
399	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(7), ADCY2(14), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADSL(1), ADSS(1), AK5(3), AMPD1(4), AMPD2(1), AMPD3(6), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5G2(2), ATP5G3(1), CANT1(1), DCK(1), ENPP1(7), ENPP3(3), ENTPD1(1), ENTPD2(1), GART(1), GDA(6), GUCY1A2(10), GUCY1A3(5), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(4), GUK1(2), HPRT1(1), IMPDH1(1), NPR1(2), NPR2(2), NT5E(2), PAPSS2(1), PDE1A(2), PDE4A(1), PDE4B(3), PDE4C(2), PDE4D(1), PDE5A(4), PDE6B(3), PDE7B(1), PDE8A(5), PDE9A(2), PFAS(4), PKLR(3), PKM2(2), POLB(1), POLD1(2), POLG(1), POLL(1), POLQ(12), POLR1B(2), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), PPAT(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RRM1(1)	35177072	193	105	193	60	50	67	34	19	23	0	0.77	1.00
400	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGF(6), EGFR(6), TF(5), TFRC(2)	3479188	20	17	19	2	8	8	2	0	2	0	0.78	1.00
401	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(2), IKBKAP(2), IKBKB(2), LTA(2), MAP3K1(2), MAP3K14(1), NFKB1(2), RELA(2), TANK(4), TNFAIP3(3), TNFRSF1B(1), TRAF1(4), TRAF3(1)	6090804	28	24	28	10	5	4	6	5	8	0	0.78	1.00
402	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(5), CARS(5), DARS(1), DARS2(5), EARS2(2), EPRS(10), FARS2(1), FARSA(2), HARS(2), HARS2(2), IARS(3), IARS2(3), KARS(2), LARS2(3), MARS(1), NARS(2), NARS2(2), PARS2(2), RARS(4), RARS2(2), SARS(2), SARS2(2), TARS(3), TARS2(2), VARS(3), VARS2(1), WARS(3), WARS2(1), YARS(1)	14615580	78	58	78	23	9	30	24	5	10	0	0.78	1.00
403	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), HMGCL(1), OXCT1(2)	901926	4	4	4	3	3	1	0	0	0	0	0.78	1.00
404	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(2), FBP2(1), GPI(5), H6PD(2), PFKM(4), PFKP(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RBKS(1), RPIA(1), TAL1(2), TALDO1(1), TKT(1)	5552176	26	25	26	12	6	8	4	3	5	0	0.78	1.00
405	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(2), FOS(1), IKBKB(2), IRAK1(3), JUN(3), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(2), NFKB1(2), PPARA(1), RELA(2), TLR2(3), TLR3(2), TLR4(10), TLR7(3), TLR9(1), TOLLIP(1), TRAF6(1)	9909082	50	41	49	16	16	11	9	6	8	0	0.78	1.00
406	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(3), IFNGR2(1), JAK1(1), JAK2(3), STAT1(2)	2203818	11	10	11	2	2	3	5	0	1	0	0.78	1.00
407	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(3), HK2(5), HK3(5), IMPA1(1), TGDS(1)	2756330	16	14	16	4	6	6	1	2	1	0	0.79	1.00
408	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(1), ITGAM(3), ITGB2(3), SELE(4), SELL(2)	3233726	18	16	18	5	5	5	5	2	1	0	0.79	1.00
409	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(6), EGFR(6), MAP2K1(2), MAP3K1(2), MAPK14(1), NCOR2(6), RARA(1), RXRA(1), THRA(1), THRB(1)	4792828	27	23	26	9	12	8	4	0	3	0	0.79	1.00
410	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(2), RDH11(1), RDH12(2), RDH13(1)	1309724	6	6	6	2	3	0	0	2	1	0	0.79	1.00
411	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(5), FOS(1), HRAS(1), JAK2(3), MAP2K1(2), MAPK3(1), RAF1(1), SHC1(1), SOS1(6), STAT5A(2)	4575846	23	22	23	2	6	7	6	1	3	0	0.79	1.00
412	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(2), DPYD(7), DPYS(4), ENPP1(7), ENPP3(3), PANK3(1), PPCS(1)	3808488	25	18	25	8	7	9	4	2	3	0	0.80	1.00
413	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(1), IDI1(1), SQLE(2)	887152	4	4	4	0	2	1	0	1	0	0	0.80	1.00
414	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(1), IL4R(1), JAK1(1), JAK2(3), TYK2(5)	2816850	13	12	13	5	1	4	5	1	2	0	0.80	1.00
415	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(1), IL4R(1), JAK1(1), JAK2(3), TYK2(5)	2816850	13	12	13	5	1	4	5	1	2	0	0.80	1.00
416	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), FURIN(1), NOTCH1(10), PSEN1(1)	2659320	13	11	13	6	2	6	0	1	4	0	0.80	1.00
417	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ABP1(4), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), ALDH3B2(1), AOC2(1), AOC3(3), AOX1(9), CARM1(1), DBH(1), DCT(1), DDC(2), ECH1(1), ESCO1(1), FAH(1), GOT2(2), GSTZ1(2), HPD(1), LCMT1(2), MYST3(9), MYST4(3), PNMT(2), PNPLA3(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), SH3GLB1(1), TAT(1), TH(1), TPO(10), TYR(3), TYRP1(2), WBSCR22(3)	15827048	87	63	87	24	23	34	11	11	8	0	0.80	1.00
418	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB4A(3)	1158068	5	5	5	9	3	2	0	0	0	0	0.81	1.00
419	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(1), B4GALT4(1), FUT3(3), FUT5(4), FUT6(2), FUT9(1), GCNT2(1), ST8SIA1(2)	4446796	22	19	22	12	7	6	6	2	1	0	0.81	1.00
420	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(3), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(2), G6PC2(1), GAPDH(2), GAPDHS(1), GCK(1), GPI(5), HK1(3), HK2(5), HK3(5), LDHAL6B(1), LDHB(2), LDHC(1), PDHA1(2), PDHA2(5), PFKL(2), PFKM(4), PFKP(2), PGAM2(1), PGK1(1), PGK2(4), PKLR(3), PKM2(2), TPI1(3)	15403764	87	64	87	27	25	33	15	8	6	0	0.81	1.00
421	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(4), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH9A1(2), AOC2(1), AOC3(3), CNDP1(3), DDC(2), HARS(2), HDC(3), HNMT(2), PRPS1(1), PRPS2(1)	6575498	31	30	31	14	10	11	6	3	1	0	0.81	1.00
422	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT3(2), ARHGEF11(7), CDC42(1), DLG4(1), LPA(11), MAP3K1(2), MAP3K5(3), MAPK8(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PDK1(1), PHKA2(2), PI3(1), PIK3CB(2), PLD1(6), PLD2(2), PLD3(1), PTK2(4), RDX(1), ROCK1(5), ROCK2(3), SERPINA4(4), SRF(2), TBXA2R(2)	13379548	76	54	75	27	11	31	18	9	7	0	0.82	1.00
423	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(9), CERK(3), CREB1(1), CREB3(2), CREB5(3), DAG1(1), EPHB2(4), FOS(1), ITPKA(1), ITPKB(4), JUN(3), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1)	7865998	42	34	41	11	12	12	10	2	6	0	0.82	1.00
424	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(4), AOC2(1), AOC3(3), CES1(2), CES7(1), DDHD1(4), ESCO1(1), LIPA(2), MYST3(9), MYST4(3), PLA1A(5), PNPLA3(1), PRDX6(1), SH3GLB1(1)	6849084	39	31	39	17	11	14	7	4	3	0	0.82	1.00
425	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	14	NDUFB5(2), NDUFS1(3), NDUFV1(2), NDUFV2(2)	1823966	9	8	9	2	4	2	2	1	0	0	0.82	1.00
426	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA3(6), GGT1(1)	1569604	7	6	7	4	1	2	3	0	1	0	0.82	1.00
427	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(3), LPL(3), RXRA(1)	1557322	7	7	7	3	2	4	0	1	0	0	0.83	1.00
428	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(3), LARS2(3), PDHA1(2), PDHA2(5)	2688156	13	12	13	2	1	6	4	1	1	0	0.83	1.00
429	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CD3D(1), CD4(1)	675510	2	2	2	2	0	1	0	0	1	0	0.83	1.00
430	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(9), CCND2(3), CCND3(1), CTNNB1(3), DVL1(3), DVL3(2), FZD1(1), FZD10(1), FZD3(4), FZD6(2), FZD7(1), FZD9(2), JUN(3), LDLR(3), MAPK10(1), MAPK9(1), MYC(1), PAFAH1B1(1), PLAU(2), PPP2R5C(5), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCI(4), PRKCQ(4), PRKD1(9), RAC1(1), SFRP4(3), TCF7(1), WNT10B(2), WNT11(1), WNT2(3), WNT2B(2), WNT3(2), WNT6(2), WNT7A(2), WNT7B(1)	16330076	103	64	102	26	32	32	22	10	7	0	0.83	1.00
431	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(2), UGDH(2), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2B15(1), UGT2B4(4)	4394820	20	19	20	4	4	6	8	1	1	0	0.83	1.00
432	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNB1(1), JAK1(1), STAT1(2), STAT2(1), TYK2(5)	2905494	13	13	13	5	3	5	1	3	1	0	0.84	1.00
433	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(5), GCLC(2), GCLM(1), GGT1(1), GPX5(1), GSS(2), GSTA2(1), GSTA4(1), GSTM3(1), GSTM4(3), GSTM5(2), GSTZ1(2), IDH1(2), MGST1(1)	4947866	25	23	25	8	7	12	4	2	0	0	0.84	1.00
434	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), CDC42(1), CHUK(2), EGFR(6), F11R(1), GIT1(1), HBEGF(1), IGSF5(2), IKBKB(2), JUN(3), LYN(1), MAP3K14(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK8(2), MAPK9(1), MET(3), NFKB1(2), NFKB2(2), NOD1(4), PAK1(1), PLCG1(1), PLCG2(3), PTPN11(2), PTPRZ1(8), RAC1(1), RELA(2), TJP1(8)	19090856	95	65	93	19	27	22	19	10	17	0	0.85	1.00
435	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSD(1), ARSE(2), GAL3ST1(1), GALC(1), GLA(2), LCT(14), NEU1(2), NEU2(2), PPAP2B(1), SMPD1(3), SMPD2(1), SPTLC2(3)	6640468	34	29	34	12	11	8	7	5	3	0	0.85	1.00
436	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(3), HLA-DRA(1), HLA-DRB1(1), LCK(2), PTPRC(3), ZAP70(2)	2464054	14	11	14	6	2	7	2	1	2	0	0.85	1.00
437	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO1(1), ACO2(3), ACSS1(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SUCLA2(2)	3552346	15	15	15	5	3	6	2	3	1	0	0.86	1.00
438	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(2), FOS(1), HRAS(1), IL2RB(2), IL2RG(1), JAK1(1), JAK3(7), JUN(3), LCK(2), MAP2K1(2), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(6), STAT5A(2), SYK(1)	6428648	36	29	35	9	9	13	9	2	3	0	0.86	1.00
439	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(1), ITGB2(3), PTPRC(3), THY1(2)	3034544	14	14	14	9	2	8	1	2	1	0	0.87	1.00
440	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12B(1), ALOX15(2), ALOX15B(1), CYP2B6(3), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2J2(1), CYP4A22(2), CYP4F2(3), CYP4F3(2), DHRS4(1), EPHX2(2), GGT1(1), GPX5(1), GPX6(2), LTA4H(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(5), PTGES(1), PTGS1(2), TBXAS1(2)	10638882	59	44	59	28	16	14	20	2	7	0	0.87	1.00
441	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(2), CD3D(1), CD4(1), CD58(1)	1701146	6	6	6	6	1	3	0	0	2	0	0.87	1.00
442	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGA4(3), ITGAL(1), ITGB1(3), ITGB2(3), SELE(4), SELL(2)	3655764	21	16	21	3	5	6	7	2	1	0	0.88	1.00
443	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(2), ACADS(2), ACAT1(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH5A1(1), ALDH9A1(2), GAD1(4), GAD2(5), HADHA(2), HMGCL(1), OXCT1(2), PDHA1(2), PDHA2(5), SDS(2)	6966742	38	31	38	16	8	18	4	4	4	0	0.88	1.00
444	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(4), ACY3(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), AMDHD1(1), AOC2(1), AOC3(3), CARM1(1), CNDP1(3), DDC(2), HARS(2), HARS2(2), HDC(3), HNMT(2), LCMT1(2), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), PRPS1(1), PRPS2(1), UROC1(1), WBSCR22(3)	10716134	52	45	52	17	22	15	8	4	3	0	0.88	1.00
445	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(1), AASS(6), ACAT1(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(4), EHMT2(1), GCDH(1), HADH(1), HADHA(2), HSD17B4(1), NSD1(8), OGDH(3), OGDHL(4), PIPOX(1), PLOD1(4), PLOD2(4), PLOD3(5), RDH11(1), RDH12(2), RDH13(1), SETD1A(6), SETDB1(3), SPCS1(1), SPCS3(2), SUV39H1(1), SUV39H2(2)	15838974	77	58	77	33	9	24	22	8	14	0	0.88	1.00
446	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FOS(1), FYN(3), JUN(3), MAPK14(1), THBS1(1)	1984344	10	9	9	1	2	2	4	2	0	0	0.89	1.00
447	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), ICAM1(2), ITGAL(1), ITGB2(3), PTPRC(3), THY1(2)	2883956	13	13	13	8	2	8	1	2	0	0	0.89	1.00
448	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(1), CHUK(2), CRADD(1), IKBKB(2), JUN(3), LTA(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K14(1), MAP4K2(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(2), TANK(4), TNFRSF1A(2), TRADD(1)	6698318	33	27	32	10	8	9	6	3	7	0	0.89	1.00
449	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	FUT9(1), GBGT1(2), GLA(2), HEXA(4), ST3GAL1(1), ST8SIA1(2)	2913504	12	11	12	5	2	5	2	2	1	0	0.89	1.00
450	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(9), CTNNB1(3), DLL1(1), DVL1(3), FZD1(1), NOTCH1(10), PSEN1(1)	5808318	28	24	28	8	6	10	5	1	6	0	0.89	1.00
451	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(1), PSMC3(1), PSMD14(3), RPN1(1), UBE2A(1), UBE3A(5)	3479544	15	15	15	3	4	6	3	0	2	0	0.89	1.00
452	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(1), ARHGDIB(1), BAG4(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), CRADD(1), DAXX(2), DFFB(2), FADD(1), GSN(2), MAP3K1(2), MAP3K14(1), MAP3K5(3), MAPK8(2), MDM2(1), NFKB1(2), NUMA1(4), PRKCD(2), PRKDC(11), PSEN1(1), PSEN2(2), PTK2(4), RASA1(5), RB1(7), RELA(2), SPTAN1(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4)	19149418	82	63	82	26	16	24	11	8	23	0	0.90	1.00
453	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), BDH1(3), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(2)	1973842	9	8	9	5	3	4	1	1	0	0	0.90	1.00
454	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACADL(2), ACADM(1), ACOX1(2), ACOX3(4), ACSL1(2), ACSL3(1), ACSL6(1), ADIPOQ(1), ANGPTL4(1), APOA2(1), APOA5(3), CD36(1), CPT1A(3), CPT1C(3), CPT2(1), CYP27A1(1), CYP4A22(2), CYP7A1(3), DBI(1), FABP5(1), FABP6(1), FABP7(1), FADS2(1), GK(4), GK2(5), HMGCS2(1), ILK(1), LPL(3), MMP1(3), NR1H3(2), PCK1(1), PCK2(1), PDPK1(1), PLTP(2), PPARA(1), PPARD(1), RXRA(1), RXRG(4), SCD(1), SCP2(1), SLC27A1(1), SLC27A2(2), SLC27A4(1), SLC27A5(4), SLC27A6(3), SORBS1(5), UBC(1), UCP1(2)	17498112	90	65	90	39	24	25	27	6	8	0	0.90	1.00
455	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(7), MAP2(8), PRKACB(2), PRKACG(1), PRKAR2B(2), PRKCE(3)	4900162	23	20	23	7	6	3	9	3	2	0	0.90	1.00
456	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), ACO2(3), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(1), IDH3B(3), IDH3G(1), MDH1(1), MDH2(1), PC(2), PCK1(1), SDHA(1), SUCLA2(2), SUCLG2(1)	5541852	25	23	25	8	5	8	3	5	4	0	0.90	1.00
457	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(5), HRAS(1), JUN(3), MAP2K1(2), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), PAK1(1), PLCG1(1), PRKCA(4), RAC1(1), RAF1(1), SHC1(1), SOS1(6), SYT1(3)	7794620	38	34	37	11	14	8	9	5	2	0	0.90	1.00
458	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOA(1), ALDOB(2), FBP2(1), FPGT(2), GCK(1), GMPPA(1), HK1(3), HK2(5), HK3(5), KHK(1), MPI(1), PFKFB1(2), PFKM(4), PFKP(2), PMM1(1), TPI1(3)	6506434	35	28	35	13	12	8	10	3	2	0	0.90	1.00
459	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), AADAC(1), ABAT(2), ACADS(2), ACAT1(1), ACSM1(5), ALDH1B1(2), ALDH2(2), ALDH5A1(1), ALDH7A1(1), ALDH9A1(2), BDH1(3), DDHD1(4), GAD1(4), GAD2(5), HADH(1), HADHA(2), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(2), OXCT1(2), PDHA1(2), PDHA2(5), PLA1A(5), PRDX6(1), RDH11(1), RDH12(2), RDH13(1)	11071778	64	45	64	23	16	24	8	10	6	0	0.90	1.00
460	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), CBS(4), DNMT1(3), DNMT3A(6), DNMT3B(3), MARS(1), MAT1A(1), MTR(4)	4733020	23	19	23	10	3	11	6	1	2	0	0.90	1.00
461	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2)	3593286	15	15	15	3	5	8	0	2	0	0	0.90	1.00
462	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADH(1), HADHA(2), HADHB(2), HSD17B4(1), PPT1(1)	2306524	8	8	8	2	1	0	2	3	2	0	0.91	1.00
463	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BAX(1), BCL2A1(1), BCL2L1(1), CASP1(1), CASP10(3), CASP2(1), CASP4(3), CASP7(2), CASP8(1), CASP9(2), CD40(1), CD40LG(2), CRADD(1), DAXX(2), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKE(3), LTA(2), MCL1(2), NFKB1(2), NGFR(1), NTRK1(3), PTPN13(3), SFRS2IP(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4), TRAF3(1), TRAF6(1)	12079436	57	43	57	23	12	19	7	7	12	0	0.91	1.00
464	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST12(1), PAPSS2(1), SULT1A1(1), SULT1A2(2), SULT1E1(1), SULT2A1(3)	2544332	10	10	10	5	2	3	2	2	1	0	0.91	1.00
465	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	HADHA(2), SDS(2)	1318802	4	4	4	5	0	1	1	0	2	0	0.91	1.00
466	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(3), CASP8(1), FADD(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	2346218	10	8	10	4	3	2	0	2	3	0	0.91	1.00
467	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(1), FARS2(1), GOT2(2), PAH(1), TAT(1), YARS(1)	2211650	8	8	8	3	4	1	1	1	1	0	0.91	1.00
468	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(1), HTR2C(2), PLCB1(6)	1924358	9	8	9	4	3	4	0	2	0	0	0.91	1.00
469	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(3), CAMK2B(2), CAMK2D(1), CDK5(1), FYN(3), GNAI1(2), GNB1(1), HRAS(1), JAK2(3), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPT(4), MYLK(5), PLCG1(1), PRKCA(4), RAF1(1), SHC1(1), SOS1(6), STAT1(2), STAT3(1), STAT5A(2), SYT1(3)	11315994	55	47	55	13	12	18	14	5	6	0	0.91	1.00
470	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(1), PRKCA(4)	1819516	6	6	6	3	2	2	1	0	1	0	0.91	1.00
471	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), HRAS(1), SHC1(1), SOS1(6)	2388582	9	9	9	1	2	1	4	1	1	0	0.91	1.00
472	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(3), HK2(5), HK3(5), IMPA1(1), TGDS(1)	3175520	16	14	16	4	6	6	1	2	1	0	0.91	1.00
473	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT1(1), HADHA(2), HADHB(2), SDS(2)	2252946	8	8	8	7	1	1	2	2	2	0	0.91	1.00
474	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(4), ANAPC4(3), ANAPC5(4), CDC27(2), CUL1(2), CUL3(8), FBXW7(10), ITCH(2), RBX1(1), SKP1(1), SKP2(1), SMURF1(2), UBA1(3), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2E2(1), UBE2E3(1), VHL(1), WWP1(1)	10982956	50	42	48	12	10	11	9	8	12	0	0.91	1.00
475	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(2), BCMO1(1)	1037384	3	3	3	3	0	1	1	0	1	0	0.91	1.00
476	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(1), ARHGDIB(1), CASP1(1), CASP10(3), CASP8(1), CASP9(2), GZMB(1), JUN(3), PRF1(1)	3454802	15	15	14	8	3	5	3	2	2	0	0.91	1.00
477	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT1(1), B4GALT3(1), B4GALT5(2), FUT8(2), ST3GAL1(1), ST3GAL4(2)	2168218	9	9	9	10	2	4	2	1	0	0	0.91	1.00
478	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(1), CASP9(2), DFFB(2), GZMB(1), PRF1(1), SCAP(4), SREBF1(2), SREBF2(2)	5027432	24	21	24	10	5	9	5	3	2	0	0.92	1.00
479	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(2), AP2M1(1), ARF1(1), BTK(4), EEA1(1), GSK3A(3), LYN(1), PDPK1(1), PFKL(2), PFKM(4), PFKP(2), PLCG1(1), PRKCE(3), RAC1(1), RPS6KB1(1), VAV2(3)	6962292	32	27	32	13	8	4	10	3	7	0	0.92	1.00
480	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), LCMT1(2), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), WBSCR22(3)	3831272	17	16	17	2	7	5	2	1	2	0	0.92	1.00
481	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), UGDH(2)	2317560	9	9	9	1	2	6	0	1	0	0	0.92	1.00
482	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACAT1(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH6A1(1), ALDH9A1(2), AOX1(9), BCKDHB(2), HADHA(2), HADHB(2), HMGCL(1), MCCC1(4), MUT(1), OXCT1(2), PCCA(2), PCCB(6), SDS(2)	9687116	49	39	49	13	6	19	11	8	5	0	0.92	1.00
483	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(1), ABP1(4), ACAT1(1), ACMSD(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), AOC2(1), AOC3(3), AOX1(9), CARM1(1), CYP1A1(7), CYP1A2(1), DDC(2), GCDH(1), HADH(1), HADHA(2), HSD17B4(1), INMT(2), KMO(2), KYNU(3), LCMT1(2), LNX1(2), NFX1(1), OGDH(3), OGDHL(4), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), TDO2(1), TPH1(1), TPH2(5), WARS(3), WARS2(1), WBSCR22(3)	16210282	86	61	86	31	21	31	15	10	9	0	0.92	1.00
484	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOA(1), ALDOB(2), FBP2(1), FPGT(2), FUK(1), GMPPA(1), HK1(3), HK2(5), HK3(5), KHK(1), MPI(1), MTMR1(1), MTMR2(1), MTMR6(4), PFKFB1(2), PFKL(2), PFKM(4), PFKP(2), PGM2(4), PMM1(1), RDH11(1), RDH12(2), RDH13(1), TPI1(3)	10174124	51	42	51	15	16	10	13	6	6	0	0.92	1.00
485	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(1), CAPN2(2), CAPNS2(1), EP300(6), HDAC1(2), MEF2D(2), NFATC2(4), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKCA(4), SYT1(3)	6598994	33	26	32	8	10	7	6	6	4	0	0.93	1.00
486	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACSL1(2), ACSL3(1), CPT1A(3), CPT2(1), DCI(1), HADHA(2), PECR(1), SCP2(1)	4528320	18	18	18	7	4	5	5	1	3	0	0.93	1.00
487	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2)	2153800	8	8	8	0	1	5	1	1	0	0	0.93	1.00
488	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2)	2153800	8	8	8	0	1	5	1	1	0	0	0.93	1.00
489	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), CASP1(1), CASP7(2), CASP8(1), GAPDH(2), INSR(7), ITCH(2), MAGI1(5), MAGI2(7), RERE(2), WWP1(1)	6378808	32	24	32	10	6	11	6	3	6	0	0.93	1.00
490	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL2RG(1), IL4(2), IL4R(1), IRS1(3), JAK1(1), JAK3(7), RPS6KB1(1), SHC1(1), STAT6(1)	4071928	19	16	19	6	3	9	5	0	2	0	0.93	1.00
491	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(1), ITPKA(1), ITPKB(4)	1687262	6	6	6	2	4	0	1	0	1	0	0.93	1.00
492	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1G(2), CAMK2B(2), CAMK2D(1), CAMK4(3), HDAC5(1), MEF2A(2), MEF2C(3), MEF2D(2), PPARA(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), SLC2A4(2), SYT1(3)	5542920	30	22	30	10	11	5	3	7	4	0	0.93	1.00
493	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(1), FMOD(1)	967608	3	3	3	2	0	2	1	0	0	0	0.93	1.00
494	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(2), FOS(1), HRAS(1), IL6R(1), JAK1(1), JAK2(3), JAK3(7), JUN(3), MAP2K1(2), MAPK3(1), PTPN11(2), RAF1(1), SHC1(1), SOS1(6), SRF(2), STAT3(1)	6555740	35	28	34	7	8	12	10	3	2	0	0.93	1.00
495	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(1), CBS(4), DNMT1(3), DNMT3A(6), DNMT3B(3), MARS(1), MAT1A(1), MTAP(1), MTR(4), TAT(1)	5640642	26	22	26	11	4	12	6	1	3	0	0.93	1.00
496	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), CHUK(2), IFNG(1), IKBKB(2), IL4(2), JUN(3), MAP3K1(2), MAP3K5(3), MAP4K5(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(2), TNFRSF9(1)	5344806	26	21	25	9	5	6	9	2	4	0	0.93	1.00
497	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(2), GOT2(2), PAH(1), TAT(1), YARS(1)	2348888	8	8	8	5	4	2	0	1	1	0	0.93	1.00
498	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(1), BCL2L1(1), CBL(1), CFLAR(1), E2F1(2), FOS(1), HRAS(1), IL2RB(2), IL2RG(1), IRS1(3), JAK1(1), JAK3(7), MAPK1(1), MAPK3(1), MYC(1), NMI(1), PIK3CA(20), PIK3R1(1), RAF1(1), RPS6KB1(1), SHC1(1), SOS1(6), STAT5A(2), SYK(1)	9874728	59	41	48	13	20	19	13	3	4	0	0.93	1.00
499	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT2(2), IARS(3), IARS2(3), ILVBL(2), LARS2(3), PDHA1(2), PDHA2(5), VARS(3), VARS2(1)	5037400	24	20	24	5	4	10	6	1	3	0	0.93	1.00
500	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(2), DFFB(2), GZMB(1), TOP2A(2), TOP2B(4)	2721976	11	10	11	5	1	4	4	1	1	0	0.93	1.00
501	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), EPOR(2), FOS(1), HRAS(1), JAK2(3), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PLCG1(1), RAF1(1), SHC1(1), SOS1(6), STAT5A(2)	5861184	28	24	27	5	8	7	8	2	3	0	0.94	1.00
502	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(1), DHRS2(1), LCMT1(2), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), WBSCR22(3)	3890012	17	16	17	2	8	4	2	1	2	0	0.94	1.00
503	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), CRADD(1), DFFB(2), FADD(1), JUN(3), MADD(3), MAP3K1(2), MAP3K7(2), MAPK8(2), PAK1(1), PRKDC(11), RB1(7), SPTAN1(2), TNFRSF1A(2), TRADD(1)	10863874	44	40	43	16	9	15	5	2	13	0	0.94	1.00
504	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	CPO(1), FECH(2), GATA1(2), HBB(2), UROD(1)	2209870	8	8	8	3	2	3	0	1	2	0	0.94	1.00
505	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(1), CABIN1(1), CAMK2B(2), CAMK4(3), CNR1(2), CREBBP(12), CSNK2A1(2), EGR2(6), EGR3(1), EP300(6), FCER1A(2), FCGR3A(3), FKBP1B(1), FOS(1), GATA3(5), GRLF1(11), GSK3A(3), HRAS(1), ICOS(2), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL1B(1), IL4(2), ITK(2), KPNA5(2), MAPK14(1), MAPK8(2), MAPK9(1), MEF2A(2), MEF2D(2), MYF5(3), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB2(2), NFKBIB(1), NUP214(4), OPRD1(1), P2RX7(1), PAK1(1), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(3), RELA(2), SFN(2), SLA(1), SP1(1), SP3(1), TGFB1(1), TRPV6(3), VAV1(7), VAV2(3), VAV3(1), XPO5(1)	24820854	139	80	138	44	40	32	30	17	20	0	0.94	1.00
506	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(2), EGR2(6), EGR3(1), MAP3K1(2), MYC(1), NFATC2(4), NFKB1(2), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(2), SYT1(3), VIP(1)	7466566	41	29	41	10	14	8	5	8	6	0	0.94	1.00
507	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(1), ARHGEF1(2), GNA12(1), GNB1(1), MYL2(1), MYLK(5), PLCB1(6), PPP1R12B(4), PRKCA(4), ROCK1(5)	5569976	30	23	30	9	6	13	6	3	2	0	0.94	1.00
508	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	MARCKS(1), NFATC2(4), NFATC3(2), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKCA(4), SP1(1), SP3(1), SYT1(3)	5691372	26	22	26	5	9	7	2	5	3	0	0.94	1.00
509	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(1), SNAP25(1)	869530	2	2	2	3	0	1	1	0	0	0	0.94	1.00
510	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CARM1(1), CREBBP(12), EP300(6), ERCC3(1), ESR1(5), GRIP1(3), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC1(2), HDAC3(1), HDAC4(4), HDAC5(1), MEF2C(3), NCOR2(6), NR0B1(4), NRIP1(3), POLR2A(1), TBP(1)	12822586	63	48	62	19	18	17	13	7	8	0	0.94	1.00
511	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(1), AKT3(2), DAG1(1), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PDK1(1), PHKA2(2), PIK3CB(2), PITX2(3), PLD1(6), PLD2(2), PLD3(1), VN1R1(2)	12327212	55	45	55	15	11	21	8	6	9	0	0.95	1.00
512	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	HADH(1), HADHA(2), HSD17B4(1), SIRT2(2), VNN2(5)	3154338	11	10	11	7	0	3	3	1	4	0	0.95	1.00
513	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(1), ACP6(2), ACPT(1), ALPL(3), ALPP(2), ALPPL2(1), CMBL(1), CYP3A4(1), CYP3A43(3), CYP3A7(1), DHRS2(1), PON1(4), PON2(1), PON3(1)	4730528	23	18	23	10	6	8	3	2	4	0	0.95	1.00
514	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(2), ACTN2(6), ACTN3(2), BCAR1(5), BCR(1), CAPN1(2), CAPNS2(1), FYN(3), HRAS(1), ITGA1(3), ITGB1(3), JUN(3), MAP2K1(2), MAPK1(1), MAPK3(1), MAPK8(2), PPP1R12B(4), PTK2(4), PXN(3), RAF1(1), ROCK1(5), SHC1(1), SOS1(6), TLN1(3), VCL(2)	12940422	68	51	67	21	17	22	14	10	5	0	0.95	1.00
515	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(1), IFNB1(1), IKBKB(2), IL1B(1), IL1RAP(2), IRAK1(3), IRAK3(3), JUN(3), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(2), NFKB1(2), RELA(2), TGFB1(1), TGFB2(2), TOLLIP(1), TRAF6(1)	8061264	39	32	38	14	14	10	6	5	4	0	0.95	1.00
516	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR1(2), IFNB1(1), MAPK8(2), NFKB1(2), RELA(2), TNFRSF11A(1), TNFSF11(1), TRAF6(1)	3013540	14	11	14	2	5	4	0	3	2	0	0.95	1.00
517	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(1), ACAT1(1), ADH5(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(1), HAGHL(1), LDHB(2), LDHC(1), LDHD(6), MDH1(1), MDH2(1), ME2(2), ME3(1), PC(2), PCK1(1), PDHA1(2), PDHA2(5), PKLR(3), PKM2(2)	9947530	45	39	45	21	10	18	8	5	4	0	0.95	1.00
518	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), HADHA(2), SDS(2)	3292822	12	12	12	5	1	6	2	1	2	0	0.96	1.00
519	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(2), SDHA(1)	1766116	5	5	5	2	0	2	1	2	0	0	0.96	1.00
520	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(7), EIF2AK4(4), EIF2B5(1), EIF5(1)	3140988	13	13	13	5	7	4	1	0	1	0	0.96	1.00
521	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(1), SRP54(1), SRP72(1), SRPR(2)	2013536	6	6	6	3	2	2	2	0	0	0	0.96	1.00
522	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(2), ACACA(1), ACADL(2), ACADM(1), ACAT1(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH6A1(1), ALDH9A1(2), HADHA(2), LDHB(2), LDHC(1), MLYCD(1), MUT(1), PCCA(2), PCCB(6), SDS(2), SUCLA2(2), SUCLG2(1)	8878106	36	34	36	11	5	16	7	3	5	0	0.96	1.00
523	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(2), ACAD9(3), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), DHRS2(1), ESCO1(1), MYST3(9), MYST4(3), PNPLA3(1), SH3GLB1(1)	6562148	29	26	29	11	7	11	4	2	5	0	0.96	1.00
524	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(5), AASDHPPT(1), AASS(6), ACAT1(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(4), EHMT2(1), GCDH(1), HADHA(2), PLOD1(4), PLOD2(4), PLOD3(5), SDS(2)	10099720	48	38	48	23	5	17	16	4	6	0	0.96	1.00
525	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), GCDH(1), HADHA(2), SDS(2)	2113928	6	6	6	7	1	1	2	0	2	0	0.96	1.00
526	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), ARHGDIB(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(3), CASP7(2), CASP8(1), CASP9(2), DFFB(2), GZMB(1), PRF1(1)	5233378	22	19	22	9	3	8	4	2	5	0	0.96	1.00
527	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(4), ADCY4(3), ADCY8(13), CACNA1A(7), CACNA1B(1), GNAS(5), GNAT3(1), GNB1(1), GRM4(1), ITPR3(1), KCNB1(1), PDE1A(2), PLCB2(5), PRKACB(2), PRKACG(1), PRKX(1), SCNN1B(1), SCNN1G(1), TAS1R1(2), TAS2R1(3), TAS2R10(3), TAS2R16(4), TAS2R38(2), TAS2R39(1), TAS2R4(1), TAS2R40(2), TAS2R41(5), TAS2R42(1), TAS2R5(1), TAS2R60(7), TAS2R7(1), TAS2R8(1), TAS2R9(3)	15460190	88	57	88	34	23	27	23	8	7	0	0.97	1.00
528	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(6), CDC25B(1), CDC25C(1), CHEK1(4), WEE1(2)	3709342	14	13	14	1	4	6	1	1	2	0	0.97	1.00
529	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(2), BCAR1(5), CAPN1(2), CAPN10(3), CAPN11(2), CAPN2(2), CAPN3(6), CAPN5(2), CAPN6(5), CAPN7(1), CAV2(1), CAV3(1), CDC42(1), DOCK1(3), FYN(3), ILK(1), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGAD(6), ITGAE(3), ITGAL(1), ITGAM(3), ITGAV(3), ITGAX(9), ITGB1(3), ITGB2(3), ITGB3(3), ITGB4(6), ITGB6(1), ITGB7(1), ITGB8(3), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAPK10(1), MAPK4(1), MAPK6(2), MAPK7(1), MYLK2(2), PAK1(1), PAK3(1), PAK4(1), PDPK1(1), PIK3R2(3), PTK2(4), PXN(3), RAC1(1), RAP1B(1), RAPGEF1(3), RHO(1), ROCK1(5), ROCK2(3), SDCCAG8(5), SHC1(1), SHC3(2), SORBS1(5), SOS1(6), TLN1(3), TNS1(6), VASP(2), VAV2(3), VAV3(1), VCL(2)	36879464	195	104	194	67	45	75	42	13	20	0	0.97	1.00
530	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(2), ACAA2(1), ACADM(1), ACADS(2), ACAT1(1), ALDH1B1(2), ALDH2(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), AOX1(9), AUH(1), BCAT2(2), BCKDHB(2), DBT(1), DLD(2), HADH(1), HADHA(2), HADHB(2), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), MCCC1(4), MUT(1), OXCT1(2), PCCA(2), PCCB(6)	11653660	57	43	57	14	11	17	12	10	7	0	0.97	1.00
531	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGEF2(3), COPA(8), GBF1(4), KDELR2(1)	4367764	18	16	18	9	4	4	6	3	1	0	0.97	1.00
532	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(3), COPS5(2), CREB1(1), EP300(6), HIF1A(1), JUN(3), NOS3(1), VHL(1)	4582432	19	17	17	8	2	7	6	3	1	0	0.97	1.00
533	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	CPOX(2), FECH(2), PPOX(1), UROD(1)	2065156	6	6	6	2	1	3	0	1	1	0	0.97	1.00
534	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT3(1), CDS1(2), CHAT(2), CHKA(2), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKZ(3), ETNK1(3), GPD1(1), GPD2(2), LYPLA1(3), PAFAH1B1(1), PCYT1B(1), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(5), PLCB2(5), PLCG1(1), PLCG2(3), PPAP2B(1)	13840390	67	51	67	24	17	25	13	5	7	0	0.97	1.00
535	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ARPC1A(2), NCK1(2), NCKAP1(4), NTRK1(3), RAC1(1), WASF3(1), WASL(2)	4129422	16	15	16	11	2	7	2	2	3	0	0.97	1.00
536	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1(1), MST1R(1)	1782314	5	5	5	2	2	2	1	0	0	0	0.97	1.00
537	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1G(2), CAMK2B(2), CAMK2D(1), CAMK4(3), CREB1(1), SYT1(3)	3177478	12	11	12	7	5	1	1	4	1	0	0.97	1.00
538	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1G(2), FPR1(1), GNB1(1), HRAS(1), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAPK1(1), MAPK14(1), MAPK3(1), NCF2(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB1(2), PAK1(1), PIK3C2G(6), PLCB1(6), PPP3CA(2), PPP3CB(4), PPP3CC(2), RAC1(1), RAF1(1), RELA(2), SYT1(3)	10537956	55	41	55	19	19	16	6	10	4	0	0.97	1.00
539	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPL(3), ALPP(2), ALPPL2(1), GCH1(1)	1834468	7	6	7	4	3	3	0	1	0	0	0.97	1.00
540	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CDC42(1), CREB1(1), CREB3(2), CREB5(3), DUSP10(3), EEF2K(3), GADD45A(1), MAP2K3(2), MAP2K6(2), MAP3K4(4), MAP3K5(3), MAP3K7(2), MAPK1(1), MAPK13(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MKNK2(1), MYEF2(3), NFKB1(2), NR2C2(1), SRF(2), TRAF6(1)	9192632	46	34	46	15	7	15	13	6	5	0	0.97	1.00
541	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(2), CAMK2D(1), DAG1(1), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), NFAT5(2), PDE6A(2), PDE6B(3), PDE6H(2), SLC6A13(4), TF(5)	9814920	43	37	43	12	17	9	8	1	8	0	0.97	1.00
542	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ7(1), NDUFA13(2)	1115170	3	3	3	2	0	2	1	0	0	0	0.97	1.00
543	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ARPC1A(2), CDC42(1), RAC1(1), WASL(2)	2180856	7	7	7	6	1	3	2	1	0	0	0.97	1.00
544	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(2), B4GALT1(1), B4GALT3(1), B4GALT5(2), DDOST(1), FUT8(2), MAN1A1(3), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(3), RPN1(1), ST6GAL1(1)	5405504	27	21	27	14	11	9	2	3	2	0	0.98	1.00
545	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAK1(1), BAX(1), BCL2L1(1), CASP8AP2(5), CASP9(2), CES1(2)	3102540	13	10	13	5	3	2	5	2	1	0	0.98	1.00
546	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(5), APOC2(2), CYP7A1(3), LDLR(3), LIPC(1), LPL(3), LRP1(10), SCARB1(3)	6764356	30	26	30	15	12	11	5	0	2	0	0.98	1.00
547	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(3), CASP7(2), CASP8(1), CFLAR(1), DAXX(2), DFFB(2), FADD(1), FAF1(1), JUN(3), MAP3K1(2), MAP3K7(2), MAPK8(2), PAK1(1), PRKDC(11), PTPN13(3), RB1(7), RIPK2(1), SPTAN1(2)	11532976	48	40	47	12	10	19	6	2	11	0	0.98	1.00
548	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(4), ELOVL5(2), ELOVL6(1), FADS1(1), FADS2(1), HADHA(2), HSD17B12(1), PECR(1), SCD(1)	4036862	16	14	16	4	3	3	4	2	4	0	0.98	1.00
549	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), HBEGF(1), IFNG(1), NR4A3(2), WDR1(1)	2985950	9	9	9	5	1	3	1	2	2	0	0.98	1.00
550	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT9(1), GCNT2(1), ST8SIA1(2)	1700256	4	4	4	3	1	1	1	0	1	0	0.98	1.00
551	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(2), ACACA(1), ACACB(8), ACADM(1), ACAT1(1), ACSS1(3), ALDH1B1(2), ALDH2(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), HADHA(2), HIBCH(1), LDHAL6B(1), LDHB(2), LDHC(1), MLYCD(1), MUT(1), PCCA(2), PCCB(6), SUCLA2(2), SUCLG2(1)	10649918	44	39	44	15	11	17	6	4	6	0	0.98	1.00
552	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	58	ATP12A(4), ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ATP7B(1), COX4I1(1), COX6B1(1), NDUFB5(2), NDUFS1(3), NDUFV1(2), NDUFV2(2), SDHA(1), UQCRB(1)	9402494	37	31	37	12	9	8	11	3	6	0	0.98	1.00
553	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25B(1), CDC25C(1), PRKCA(4)	2502858	7	7	7	3	1	3	1	1	1	0	0.98	1.00
554	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAP3K14(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(2), TNFRSF13B(1), TNFSF13(1), TRAF3(1), TRAF5(2), TRAF6(1)	3974740	16	13	16	7	5	3	1	1	6	0	0.98	1.00
555	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(2), CDC42(1), CREB1(1), DAXX(2), HRAS(1), HSPB2(1), MAP2K6(2), MAP3K1(2), MAP3K5(3), MAP3K7(2), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MEF2A(2), MEF2C(3), MEF2D(2), MYC(1), PLA2G4A(5), RAC1(1), RPS6KA5(4), SHC1(1), STAT1(2), TGFB1(1), TGFB2(2), TRADD(1)	9996480	50	37	50	19	12	15	13	5	5	0	0.98	1.00
556	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BAK1(1), BAX(1), BCL2L1(1), BIRC3(3), CASP7(2), CASP8(1), CASP9(2), DFFB(2)	3689762	14	12	14	5	3	3	3	2	3	0	0.98	1.00
557	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO1(1), ACO2(3), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(1), IDH3B(3), IDH3G(1), MDH1(1), MDH2(1), OGDH(3), OGDHL(4), PC(2), PCK1(1), PCK2(1), SDHA(1), SUCLA2(2), SUCLG2(1)	8013026	33	29	33	17	7	11	4	6	5	0	0.98	1.00
558	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(2), ACTN2(6), ACTN3(2), CAPN1(2), CAPNS2(1), ITGA1(3), ITGB1(3), ITGB3(3), PTK2(4), PXN(3), RAC1(1), SPTAN1(2), TLN1(3)	7784474	36	28	36	17	12	9	4	7	4	0	0.98	1.00
559	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22(1), IL22RA2(1), JAK1(1), JAK2(3), JAK3(7), STAT1(2), STAT3(1), STAT5A(2), TYK2(5)	5072466	23	18	23	8	5	10	5	1	2	0	0.98	1.00
560	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(1), CBS(4), GGT1(1), LCMT1(2), MARS(1), MAT1A(1), PAPSS2(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), SEPHS1(3), WBSCR22(3)	6761864	28	25	28	9	10	10	2	1	5	0	0.98	1.00
561	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), CYP2C19(6), CYP2C9(2), DHRS2(1), ESCO1(1), HADHA(2), MYST3(9), MYST4(3), PNPLA3(1), SH3GLB1(1)	8198324	34	29	34	15	8	12	6	2	6	0	0.99	1.00
562	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLB(1), POLD1(2), POLD3(1), POLE2(2), POLE4(1), POLG(1), POLG2(1), POLI(2), POLK(3), POLL(1), POLQ(12), PRIM1(2), PRIM2(10), REV1(5), REV3L(3), RFC5(1)	11221120	52	38	52	15	13	13	12	4	10	0	0.99	1.00
563	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), GART(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3), MTHFR(1), MTR(4)	4817926	17	16	17	6	3	3	8	2	1	0	0.99	1.00
564	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(2), IKBKAP(2), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(2), RELA(2), TNFAIP3(3), TRAF3(1), TRAF6(1)	4931312	18	14	18	7	5	2	4	2	5	0	0.99	1.00
565	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CDC25B(1), CDC25C(1), CDK7(1), XPO1(2)	2376300	6	6	6	4	0	2	1	3	0	0	0.99	1.00
566	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), CSF1(2), IL4(2)	1697764	5	4	5	5	1	2	1	0	1	0	0.99	1.00
567	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), ADSS(1), HPRT1(1), IMPDH1(1), MTHFD2(3), POLB(1), POLD1(2), POLG(1), PRPS2(1), RRM1(1)	3494318	13	11	13	3	3	5	3	1	1	0	0.99	1.00
568	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(2), CAD(8), CANT1(1), CDA(1), CTPS(2), CTPS2(2), DCK(1), DPYD(7), DPYS(4), ENTPD1(1), ENTPD3(1), ENTPD6(3), NME4(1), NME7(2), NT5C1A(2), NT5C1B(1), NT5C2(2), NT5C3(3), NT5E(2), PNPT1(2), POLA1(4), POLD1(2), POLD3(1), POLE2(2), POLE4(1), POLR1A(2), POLR1B(2), POLR1D(1), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(1), PRIM1(2), PRIM2(10), RFC5(1), RRM1(1), RRM2B(2), TXNRD1(2), TXNRD2(2), UMPS(1), UPP1(3), UPP2(1), UPRT(1)	22105464	99	68	98	37	18	36	18	6	21	0	0.99	1.00
569	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GALT6(1), B3GAT1(2), B3GAT2(2), CHPF(1), CHST12(1), CHST3(2), DSE(1), XYLT1(2)	4030810	12	11	12	9	1	4	3	2	2	0	0.99	1.00
570	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(2), ALOX15B(1), GGT1(1), LTA4H(2), PLA2G2A(1), PLA2G6(5), PTGES(1), PTGS1(2), TBXAS1(2)	4144552	17	14	17	6	4	9	4	0	0	0	0.99	1.00
571	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(4), GGT1(1), MARS(1), MAT1A(1), PAPSS2(1), SEPHS1(3)	3369540	12	10	12	7	3	6	0	0	3	0	0.99	1.00
572	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), CASP8(1), FADD(1), MAP2K1(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(2), NSMAF(2), RAF1(1), RELA(2), SMPD1(3), TNFRSF1A(2), TRADD(1)	5630140	24	18	24	10	8	6	5	2	3	0	0.99	1.00
573	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT3(1), AGPAT6(1), CDS1(2), CHAT(2), CHKA(2), CRLS1(1), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKI(7), DGKZ(3), ESCO1(1), ETNK1(3), GPAM(2), GPD1(1), GPD1L(1), GPD2(2), LYPLA1(3), MYST3(9), MYST4(3), PCYT1B(1), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G5(3), PLA2G6(5), PLD1(6), PLD2(2), PNPLA3(1), PPAP2B(1), PTDSS1(1), SH3GLB1(1)	18095124	94	60	94	38	22	36	17	7	12	0	0.99	1.00
574	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), NR1I3(1), PTGS1(2)	1417058	4	3	4	4	1	2	0	1	0	0	0.99	1.00
575	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(2), POLG(1), POLL(1), POLQ(12)	4560360	17	15	17	3	4	6	3	3	1	0	0.99	1.00
576	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(1), ACACB(8), ACAT1(1), ACOT12(1), ACSS1(3), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(1), HAGHL(1), LDHAL6B(1), LDHB(2), LDHC(1), LDHD(6), MDH1(1), MDH2(1), ME2(2), ME3(1), PC(2), PCK1(1), PCK2(1), PDHA1(2), PDHA2(5), PKLR(3), PKM2(2)	12575344	57	44	57	27	17	22	8	5	5	0	0.99	1.00
577	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	ATF2(2), BRAF(7), CEBPA(1), CHUK(2), CREB1(1), DAXX(2), FOS(1), HRAS(1), IKBKB(2), JUN(3), MAP2K1(2), MAP2K3(2), MAP2K5(1), MAP2K6(2), MAP3K1(2), MAP3K11(2), MAP3K12(3), MAP3K13(5), MAP3K14(1), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K7(2), MAP3K9(3), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(5), MAP4K5(1), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK4(1), MAPK6(2), MAPK7(1), MAPK8(2), MAPK9(1), MAPKAPK2(1), MAPKAPK5(3), MEF2A(2), MEF2C(3), MEF2D(2), MKNK2(1), MYC(1), NFKB1(2), PAK1(1), RAC1(1), RAF1(1), RELA(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KB1(1), SHC1(1), SP1(1), STAT1(2), TGFB1(1), TGFB2(2), TRADD(1)	26589284	122	77	120	42	30	35	26	14	17	0	0.99	1.00
578	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(1), PSMB8(2)	2341234	6	6	6	3	2	2	1	0	1	0	0.99	1.00
579	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG13(6), ALG2(2), ALG5(2), ALG6(2), B4GALT1(1), B4GALT3(1), DDOST(1), FUT8(2), GANAB(5), MAN1A1(3), MAN1A2(3), MAN1C1(3), MAN2A1(3), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(4), RPN1(1), ST6GAL1(1), STT3B(1)	11591360	55	39	55	21	18	20	5	6	6	0	0.99	1.00
580	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1A(3)	1683524	3	3	3	1	2	0	0	1	0	0	0.99	1.00
581	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	MDH1(1), PC(2), PDHA1(2), SLC25A11(1)	2508910	6	6	6	4	0	3	0	2	1	0	0.99	1.00
582	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALT1(2), B3GALT2(2), B3GALT4(1), B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(1), B4GALT4(1), B4GALT6(1), FUT3(3), FUT5(4), FUT6(2), FUT9(1), GBGT1(2), GCNT2(1), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(1), PIGQ(1), PIGX(1), PIGZ(2), ST3GAL1(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC3(3), ST6GALNAC5(2), ST8SIA1(2)	13400908	56	44	56	31	14	12	17	6	7	0	0.99	1.00
583	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(8), ACSL1(2), ACSL3(1), ACSL6(1), ADIPOQ(1), ADIPOR2(2), AKT1(1), AKT3(2), CD36(1), CHUK(2), CPT1A(3), CPT1C(3), CPT2(1), G6PC(2), G6PC2(1), IKBKB(2), IRS1(3), IRS2(2), IRS4(2), JAK1(1), JAK2(3), JAK3(7), LEPR(10), MAPK10(1), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), NFKBIB(1), PCK1(1), PCK2(1), POMC(1), PPARA(1), PPARGC1A(5), PRKAA2(3), PRKAG2(4), PRKAG3(2), PRKCQ(4), PTPN11(2), RELA(2), RXRA(1), RXRG(4), SLC2A4(2), STAT3(1), STK11(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TYK2(5)	22732024	116	71	115	32	37	40	21	7	11	0	0.99	1.00
584	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(1), CASP9(2), DAXX(2), FAS(1), FASLG(1), HSPB2(1), MAPKAPK2(1)	3068186	10	9	10	9	4	2	2	1	1	0	0.99	1.00
585	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), GART(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3), MTHFR(1), MTR(4)	5119102	17	16	17	6	3	3	8	2	1	0	0.99	1.00
586	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), EPOR(2), GRIN1(1), HIF1A(1), JAK2(3), NFKB1(2), RELA(2), SOD2(1)	3452132	13	9	13	1	3	3	3	1	3	0	1.00	1.00
587	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(12), CTBP1(1), DLL1(1), DLL3(1), DLL4(1), DTX2(2), DTX3(2), DTX3L(1), DTX4(1), DVL1(3), DVL3(2), EP300(6), HDAC1(2), JAG2(1), LFNG(1), MAML1(2), MAML2(5), MFNG(1), NCOR2(6), NCSTN(3), NOTCH1(10), NOTCH2(6), NOTCH3(4), NOTCH4(3), PSEN1(1), PSEN2(2), PSENEN(1), SNW1(2)	19396660	83	62	82	28	21	25	16	6	15	0	1.00	1.00
588	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC3(3), CASP8(1), CFLAR(1), FADD(1), JUN(3), MAP3K7(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), NR2C2(1), RALBP1(1), TNFAIP3(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	7490062	31	23	30	13	6	10	4	7	4	0	1.00	1.00
589	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS2(1), ESCO1(1), MYST3(9), MYST4(3), PNPLA3(1), SH3GLB1(1)	4289088	16	13	16	8	3	6	3	1	3	0	1.00	1.00
590	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(5), CRY1(1), CRY2(2), PER1(4), PER2(2), PER3(1)	4651140	17	14	17	9	0	8	7	1	1	0	1.00	1.00
591	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BNIP1(1), GOSR1(1), SEC22B(4), SNAP25(1), STX10(1), STX11(1), STX5(2), STX7(1), TSNARE1(1), USE1(1), YKT6(1)	4427750	15	14	15	9	3	5	4	2	1	0	1.00	1.00
592	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT2(1), AOC2(1), AOC3(3), CBS(4), CHDH(1), CHKA(2), DAO(1), DLD(2), DMGDH(1), GATM(1), GLDC(4), GNMT(1), PHGDH(2), PIPOX(1), PISD(1), PSAT1(1), PSPH(1), RDH11(1), RDH12(2), RDH13(1), SARDH(4), SARS(2), SARS2(2), SDS(2), TARS(3), TARS2(2)	11695846	51	38	51	18	12	18	12	4	5	0	1.00	1.00
593	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST2(1), XYLT1(2)	1890716	3	3	3	3	0	2	1	0	0	0	1.00	1.00
594	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST2(1), XYLT1(2)	1890716	3	3	3	3	0	2	1	0	0	0	1.00	1.00
595	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), PGAP1(3), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(1), PIGQ(1), PIGX(1), PIGZ(2)	6629788	22	19	22	15	4	3	5	6	4	0	1.00	1.00
596	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDPS(1), IDI1(1), MVD(1), SC5DL(1), SQLE(2)	3072458	8	8	8	4	2	3	2	1	0	0	1.00	1.00
597	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(2), FDPS(1), HMGCS1(1), IDI1(1), MVD(1), NSDHL(1), SC5DL(1), SQLE(2)	3632980	10	10	10	4	2	4	2	2	0	0	1.00	1.00
598	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(1), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(1), EEF2K(3), EIF2AK3(7), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF4A1(4), EIF4A2(2), EIF4G1(6), EIF4G3(3), EIF5(1), EIF5B(1), ETF1(1), KIAA0664(1), PABPC1(2), PABPC3(6), PAIP1(1), SLC35A4(1)	12059144	49	41	49	19	9	17	15	3	5	0	1.00	1.00
599	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(1), PSMC2(4), PSMC3(1), PSMD1(2), PSMD11(1), PSMD12(1), PSMD13(1)	4277518	14	13	14	6	5	6	2	0	1	0	1.00	1.00
600	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(4), AGXT2(1), AOC2(1), AOC3(3), CBS(4), CHDH(1), CHKA(2), DAO(1), DLD(2), DMGDH(1), GATM(1), GLDC(4), PISD(1), PLCB2(5), PLCG1(1), PLCG2(3), PSPH(1), SARDH(4), SARS(2), TARS(3)	11524254	45	36	45	15	12	15	11	3	4	0	1.00	1.00
601	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACAT1(1), ACOX1(2), ACOX3(4), ACSL1(2), ACSL3(1), ACSL6(1), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), CPT1A(3), CPT1C(3), CPT2(1), CYP4A22(2), DCI(1), GCDH(1), HADH(1), HADHA(2), HADHB(2), HSD17B4(1), PECI(1)	13166660	51	43	51	18	11	18	10	8	4	0	1.00	1.00
602	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10(1), JAK1(1), STAT1(2), STAT3(1), STAT5A(2)	3285880	9	8	9	5	2	4	2	1	0	0	1.00	1.00
603	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL10L(3), RPL14(1), RPL19(1), RPL32(1), RPL37(1), RPL3L(1), RPL7(1), RPL8(2), RPS11(1), RPS18(1), RPS2(1), RPS21(1), RPS26(1), RPS6(1), RPS8(1)	6262930	18	18	18	11	4	4	6	3	1	0	1.00	1.00
604	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP1(1), ARHGAP4(1), ARHGAP5(1), ARHGAP6(5), ARHGEF1(2), ARHGEF11(7), ARHGEF5(1), ARPC1A(2), CFL1(2), DIAPH1(1), GSN(2), MYL2(1), MYLK(5), OPHN1(1), PIP5K1A(3), PIP5K1B(2), PPP1R12B(4), ROCK1(5), TLN1(3), VCL(2)	12577124	51	40	50	14	8	20	13	7	3	0	1.00	1.00
605	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(1), ACACB(8), MCAT(1), OLAH(1), OXSM(1)	4429352	12	11	12	8	6	4	1	0	1	0	1.00	1.00
606	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(2), FDPS(1), GGPS1(2), HSD17B7(1), IDI1(1), IDI2(2), MVD(1), NSDHL(1), SC5DL(1), SQLE(2), TM7SF2(1)	5284998	15	14	15	5	4	5	4	2	0	0	1.00	1.00
607	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(1), ACOT11(1), DHRS2(1), ESCO1(1), GCDH(1), HADHA(2), MYST3(9), MYST4(3), PNPLA3(1), SH3GLB1(1)	6846592	21	18	21	13	4	7	4	1	5	0	1.00	1.00
608	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), DFFB(2), FADD(1), GAS2(2), MAP3K14(1), NFKB1(2), RELA(2), SPTAN1(2), TNFRSF10A(1), TNFRSF10B(1), TRADD(1)	9154184	30	24	30	12	7	8	3	5	7	0	1.00	1.00
609	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(2), CDC40(2), CLK2(1), CLK3(1), CLK4(2), COL2A1(8), CPSF1(3), CPSF2(2), CPSF3(1), CPSF4(1), CSTF2(2), CSTF2T(2), CSTF3(1), DDX1(5), DHX15(2), DHX16(1), DHX38(1), DHX8(1), DHX9(5), DICER1(7), FUS(1), METTL3(1), NCBP1(2), NXF1(1), PAPOLA(1), POLR2A(1), PRPF3(1), PRPF4(2), PRPF4B(5), PRPF8(5), PSKH1(1), PTBP2(1), RBM17(1), RBM5(1), RNPS1(1), SF3A1(1), SF3A2(2), SF3A3(2), SF3B1(2), SF3B2(2), SF3B4(1), SF4(2), SFRS12(1), SFRS14(4), SFRS2(2), SFRS6(1), SFRS8(2), SNRPA(2), SNRPB(3), SNRPD1(1), SNRPD2(1), SNRPN(1), SPOP(1), SRPK1(2), SRRM1(2), SUPT5H(2), XRN2(2)	28537138	114	74	112	30	26	32	33	10	13	0	1.00	1.00
610	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1)	3743518	7	6	7	2	2	1	0	1	3	0	1.00	1.00
611	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(4), CDC7(1), DIAPH2(1), GMNN(2), MCM10(3), MCM2(1), MCM3(1), MCM4(3), MCM5(6), MCM6(1), MCM7(3), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), POLD1(2), POLD3(1), POLE2(2), PRIM1(2), RFC1(1), RFC4(3), RFC5(1), RPA4(2), UBB(1), UBC(1)	13878660	46	38	46	15	11	13	14	1	7	0	1.00	1.00
612	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	CAD(8), CANT1(1), CDA(1), CTPS(2), CTPS2(2), DCK(1), DPYD(7), DPYS(4), ENTPD1(1), NT5E(2), POLB(1), POLD1(2), POLG(1), POLL(1), POLQ(12), POLR1B(2), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), RRM1(1), TXNRD1(2), UMPS(1), UPP1(3)	15680732	60	43	60	12	11	23	11	6	9	0	1.00	1.00
613	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(2), POLR1B(2), POLR1D(1), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(1)	6292478	15	13	15	12	5	4	1	2	3	0	1.00	1.00
614	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(1), ERCC3(1), GTF2B(1), GTF2E1(1), GTF2H4(1), ILK(1), POLR1A(2), POLR1B(2), POLR2A(1), POLR2B(2), POLR2E(1), POLR3B(2), POLR3D(1), POLR3E(2), POLR3H(1), TAF9(2), TBP(1)	9538486	23	19	23	14	7	4	3	3	6	0	1.00	1.00
615	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPL(3), ALPP(2), ALPPL2(1), ASCC3(9), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(1), DDX41(2), DDX50(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENTPD7(1), ERCC3(1), GCH1(1), IFIH1(3), NUDT8(1), RAD54L(1), SETX(10), SKIV2L2(2), SMARCA2(2)	17193732	54	37	54	23	14	21	12	3	4	0	1.00	1.00
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		407442	0	0	0	0	0	0	0	0	0	0	1.00	1.00
