rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	225	ADORA1(3), ADORA2A(5), ADRA1A(2), ADRA1B(3), ADRA2B(4), ADRA2C(2), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(1), C5AR1(1), CALCR(5), CALCRL(3), CCKAR(2), CCKBR(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), CNR1(2), CNR2(2), CRHR1(2), CRHR2(2), CTSG(3), CYSLTR1(2), CYSLTR2(1), DRD1(1), DRD2(2), DRD3(5), DRD4(1), DRD5(3), EDNRA(1), EDNRB(3), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), FSHB(1), GABBR1(1), GABBR2(2), GABRA1(6), GABRA3(4), GABRA4(3), GABRA5(4), GABRB1(3), GABRB2(5), GABRD(2), GABRE(4), GABRG2(4), GABRP(1), GABRQ(5), GABRR1(2), GABRR2(2), GALR1(3), GH2(2), GHR(2), GHRHR(3), GHSR(2), GLP1R(1), GLP2R(3), GLRA1(2), GLRA2(4), GLRA3(3), GLRB(3), GPR156(1), GPR35(1), GPR50(4), GPR63(2), GPR83(2), GRIA1(6), GRIA2(3), GRIA3(8), GRIA4(7), GRID1(10), GRID2(12), GRIK1(4), GRIK2(8), GRIK3(7), GRIK4(3), GRIK5(1), GRIN1(1), GRIN2A(13), GRIN2C(2), GRIN2D(2), GRIN3A(7), GRIN3B(4), GRM1(10), GRM2(2), GRM4(1), GRM6(4), GRM7(8), GRM8(8), GRPR(2), GZMA(4), HCRTR2(3), HRH1(3), HRH2(1), HRH3(1), HRH4(3), HTR1A(5), HTR1B(3), HTR1E(4), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(3), HTR5A(3), HTR6(1), HTR7(3), LEPR(10), LHB(1), LHCGR(7), LTB4R2(1), MAS1(3), MC2R(2), MC3R(2), MC4R(1), MC5R(3), MCHR1(2), MCHR2(3), MTNR1A(1), NMBR(2), NMUR2(1), NPBWR1(1), NPY1R(3), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(2), OPRD1(1), OPRM1(2), OXTR(1), P2RX2(1), P2RX3(4), P2RX4(1), P2RX7(1), P2RY1(2), P2RY10(2), P2RY13(1), P2RY14(3), P2RY2(1), P2RY4(1), P2RY6(1), PARD3(5), PPYR1(3), PRL(1), PRLHR(1), PRLR(5), PRSS1(3), PRSS3(2), PTAFR(3), PTGDR(5), PTGER2(2), PTGER3(5), PTGER4(2), PTGFR(2), PTGIR(1), PTH2R(3), RXFP1(7), SSTR1(1), SSTR2(2), SSTR3(1), SSTR4(2), SSTR5(1), TAAR1(4), TAAR2(2), TAAR5(5), TAAR6(4), TAAR8(2), TAAR9(2), TACR1(2), TACR3(3), TBXA2R(2), THRA(1), THRB(1), TRHR(1), TRPV1(2), TSHR(1)	56455370	526	161	525	172	145	179	113	31	58	0	1.89e-09	1.17e-06
2	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	160	ADORA1(3), ADORA2A(5), ADRA1A(2), ADRA1B(3), ADRA1D(2), ADRA2C(2), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(1), CCBP2(3), CCKAR(2), CCKBR(1), CCR1(2), CCR10(1), CCR3(1), CCR4(3), CCR6(2), CCR8(1), CCRL1(2), CCRL2(1), CHML(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), CNR1(2), CNR2(2), CX3CR1(3), CXCR3(1), CXCR4(5), DRD1(1), DRD2(2), DRD3(5), DRD4(1), DRD5(3), EDNRA(1), EDNRB(3), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), GALR1(3), GALT(1), GHSR(2), GPR17(3), GPR174(4), GPR27(1), GPR35(1), GPR37(2), GPR37L1(2), GPR50(4), GPR6(2), GPR63(2), GPR77(3), GPR83(2), GPR85(2), GPR87(4), GRPR(2), HCRTR2(3), HRH1(3), HRH2(1), HRH3(1), HTR1A(5), HTR1B(3), HTR1E(4), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(3), HTR5A(3), HTR6(1), HTR7(3), LHCGR(7), MAS1(3), MC3R(2), MC4R(1), MC5R(3), MTNR1A(1), NMBR(2), NMUR2(1), NPY1R(3), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(2), OPN1SW(1), OPN3(1), OPRD1(1), OPRM1(2), OR10A5(1), OR11A1(3), OR12D3(4), OR1F1(1), OR1Q1(2), OR2H1(1), OR5V1(1), OXTR(1), P2RY1(2), P2RY10(2), P2RY13(1), P2RY14(3), P2RY2(1), P2RY6(1), PPYR1(3), PTAFR(3), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), RGR(1), RHO(1), SSTR1(1), SSTR2(2), SSTR3(1), SSTR4(2), SUCNR1(2), TBXA2R(2), TRHR(1)	32196462	273	134	273	97	70	95	61	15	32	0	0.000019	0.0058
3	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(3), AGT(1), AGTR1(2), AGTR2(3), ANPEP(5), CMA1(2), CPA3(4), CTSA(2), CTSG(3), ENPEP(7), LNPEP(2), MAS1(3), MME(8), NLN(2), THOP1(1)	5741924	52	46	52	14	10	21	8	4	9	0	0.0012	0.24
4	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA1B(3), ADRA1D(2), ADRA2C(2), ADRB2(3), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), DRD1(1), DRD2(2), DRD3(5), DRD4(1), DRD5(3), HRH1(3), HRH2(1), HTR1A(5), HTR1B(3), HTR1E(4), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(3), HTR5A(3), HTR6(1), HTR7(3)	7002876	69	51	69	27	15	25	22	3	4	0	0.0026	0.39
5	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	7	GABRA1(6), GABRA3(4), GABRA4(3), GABRA5(4), PRKCE(3)	1635108	20	19	20	4	8	7	3	0	2	0	0.0046	0.39
6	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	130	ACTB(1), COL11A2(10), COL17A1(4), COL1A1(8), COL1A2(12), COL2A1(8), COL3A1(10), COL4A1(6), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(5), COL5A2(11), COL5A3(11), COL6A3(10), COMP(1), DES(2), DSC1(5), DSC2(1), DSC3(6), DSG1(8), DSG2(2), DSG3(3), DSG4(5), FN1(16), GJA1(4), GJA10(5), GJA8(3), GJA9(1), GJB2(1), GJB4(1), GJC1(2), GJC2(1), GJC3(1), GJD2(2), GJD4(2), IBSP(4), INA(2), ITGA6(3), ITGB4(6), KRT1(1), KRT10(1), KRT12(3), KRT13(2), KRT14(1), KRT16(3), KRT17(2), KRT18(2), KRT2(4), KRT20(2), KRT23(2), KRT24(3), KRT27(2), KRT28(1), KRT3(2), KRT31(1), KRT32(2), KRT33A(1), KRT35(1), KRT36(2), KRT37(2), KRT4(1), KRT5(1), KRT6A(1), KRT6B(2), KRT71(2), KRT72(2), KRT73(6), KRT75(1), KRT76(2), KRT77(3), KRT79(3), KRT81(3), KRT82(1), KRT84(1), KRT85(1), KRT9(1), LAMA1(12), LAMA2(18), LAMA3(7), LAMA4(13), LAMA5(6), LAMB1(5), LAMB2(2), LAMB3(1), LAMB4(3), LAMC1(8), LAMC2(2), LAMC3(1), NES(11), PRPH(2), RELN(24), THBS1(1), THBS3(3), THBS4(1), TNC(11), TNXB(15), VIM(4), VWF(15)	63492600	440	149	440	126	114	153	95	32	46	0	0.0046	0.39
7	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	11	CASR(8), GABBR1(1), GPRC5A(1), GPRC5C(4), GRM1(10), GRM2(2), GRM4(1), GRM7(8), GRM8(8)	4577092	43	36	43	18	8	12	11	6	6	0	0.0049	0.39
8	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	19	F10(3), F11(3), F12(1), F5(14), F8(9), F9(4), FGA(5), FGB(3), FGG(1), LPA(11), PLAT(1), PLAU(2), PLG(1), SERPINB2(3), SERPINF2(3), VWF(15)	9118406	79	59	79	17	12	31	22	6	8	0	0.0054	0.39
9	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(7), ADCY8(13), ARAF(3), BRAF(7), CACNA1C(12), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CHP(2), CREBBP(12), EP300(6), GRIA1(6), GRIA2(3), GRIN1(1), GRIN2A(13), GRIN2C(2), GRIN2D(2), GRM1(10), HRAS(1), ITPR1(4), ITPR2(11), ITPR3(1), KRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), RAF1(1), RAP1B(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA6(4)	26244498	186	110	185	56	56	53	34	22	21	0	0.0058	0.39
10	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	9	AKR1C4(1), AKR1D1(4), CYP11A1(2), CYP17A1(1), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(3)	1875230	21	19	21	2	5	8	3	3	2	0	0.0069	0.39
11	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	9	AKR1C4(1), AKR1D1(4), CYP11A1(2), CYP17A1(1), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(3)	1875230	21	19	21	2	5	8	3	3	2	0	0.0069	0.39
12	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	61	AKT1(1), AKT3(2), BLNK(1), BTK(4), CARD11(3), CD19(2), CD22(5), CD81(1), CHP(2), CHUK(2), CR2(9), FCGR2B(2), FOS(1), HRAS(1), IKBKB(2), INPP5D(5), JUN(3), KRAS(1), LILRB3(3), LYN(1), MALT1(1), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB1(2), NFKB2(2), NFKBIB(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG2(3), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), RAC1(1), RASGRP3(6), SYK(1), VAV1(7), VAV2(3), VAV3(1)	19679502	122	87	121	36	30	31	18	20	23	0	0.010	0.53
13	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(2)	537204	8	8	8	3	3	1	3	0	1	0	0.013	0.63
14	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	20	DLG4(1), GRIN1(1), GRIN2A(13), GRIN2C(2), GRIN2D(2), NOS1(10), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), SYT1(3)	6076030	52	43	52	13	17	15	5	7	8	0	0.017	0.74
15	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	64	AGTR1(2), AGTR2(3), ATP8A1(5), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(1), CCKAR(2), CCKBR(1), CCR1(2), CCR10(1), CCR3(1), CCR4(3), CCR6(2), CCR8(1), CX3CR1(3), CXCR3(1), CXCR4(5), EDNRA(1), EDNRB(3), FPR1(1), GALR1(3), GALT(1), GHSR(2), GPR77(3), GRPR(2), LHCGR(7), MC2R(2), MC3R(2), MC4R(1), MC5R(3), NMBR(2), NPY1R(3), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(2), OPRD1(1), OPRM1(2), OXTR(1), PPYR1(3), SSTR1(1), SSTR2(2), SSTR3(1), SSTR4(2), TACR1(2), TACR3(3), TRHR(1), TSHR(1)	13470328	107	70	107	39	25	38	20	5	19	0	0.020	0.83
16	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(9), NRG2(2), NRG3(5), PRKCA(4), PSEN1(1)	2417774	21	21	21	6	3	8	3	2	5	0	0.023	0.90
17	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADCY1(7), ADRB2(3), GNAS(5), PLCE1(11), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	3962102	34	31	33	10	13	8	5	4	4	0	0.028	0.98
18	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	244	ACVR1B(3), ACVR1C(3), AKT1(1), AKT3(2), ARRB1(2), ATF2(2), BDNF(1), BRAF(7), CACNA1A(7), CACNA1B(1), CACNA1C(12), CACNA1D(3), CACNA1E(14), CACNA1F(8), CACNA1G(5), CACNA1H(5), CACNA1I(8), CACNA1S(5), CACNA2D1(8), CACNA2D2(3), CACNA2D3(1), CACNA2D4(6), CACNB2(2), CACNB3(2), CACNB4(1), CACNG3(2), CACNG4(2), CACNG6(1), CACNG7(4), CD14(1), CDC25B(1), CDC42(1), CHP(2), CHUK(2), DAXX(2), DUSP10(3), DUSP16(1), DUSP4(2), DUSP5(4), DUSP6(1), DUSP7(1), DUSP9(2), EGF(6), EGFR(6), FAS(1), FASLG(1), FGF10(2), FGF12(3), FGF14(1), FGF2(2), FGF23(1), FGF3(1), FGF5(2), FGF6(2), FGF8(1), FGFR1(1), FGFR2(3), FGFR3(2), FGFR4(1), FLNA(8), FLNB(3), FLNC(11), FOS(1), GADD45A(1), GADD45G(1), GNA12(1), GNG12(1), HRAS(1), IKBKB(2), IL1B(1), IL1R2(3), JUN(3), KRAS(1), MAP2K1(2), MAP2K3(2), MAP2K5(1), MAP2K6(2), MAP3K1(2), MAP3K12(3), MAP3K13(5), MAP3K14(1), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K7(2), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(5), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MAPKAPK2(1), MAPKAPK5(3), MAPT(4), MEF2C(3), MKNK2(1), MOS(4), MRAS(2), MYC(1), NFATC2(4), NFATC4(1), NFKB1(2), NFKB2(2), NLK(2), NR4A1(4), NTF3(3), NTRK1(3), NTRK2(1), PAK1(1), PDGFB(1), PDGFRA(8), PDGFRB(4), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PPM1A(2), PPM1B(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), PTPN5(1), PTPRR(7), RAC1(1), RAF1(1), RAP1B(1), RAPGEF2(5), RASA1(5), RASA2(3), RASGRF1(5), RASGRF2(4), RASGRP1(1), RASGRP3(6), RASGRP4(4), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KA6(4), RRAS2(2), SOS1(6), SOS2(5), SRF(2), STK3(2), STK4(2), TAOK1(6), TAOK2(5), TAOK3(3), TGFB1(1), TGFB2(2), TGFBR2(3), TNFRSF1A(2), TRAF6(1)	77801130	477	153	472	136	107	169	89	46	66	0	0.029	0.98
19	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	9	EPX(4), GBA3(6), LPO(2), MPO(3), PRDX1(1), PRDX6(1), TYR(3)	2183170	20	18	20	6	2	6	10	0	2	0	0.035	1.00
20	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(9), CD38(1), ENPP1(7), ENPP3(3), NADSYN1(6), NMNAT2(2), NNT(7), NT5E(2)	3938428	37	30	37	6	7	16	7	4	3	0	0.047	1.00
21	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CD3D(1), CXCR3(1), ETV5(1), IFNG(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL18R1(2), JAK2(3), JUN(3), MAP2K6(2), MAPK14(1), MAPK8(2), STAT4(4), TYK2(5)	4886634	35	34	34	7	7	12	8	3	5	0	0.050	1.00
22	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(5), GNB1(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4)	2534364	20	20	20	6	4	8	3	2	3	0	0.051	1.00
23	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	IFNG(1), IFNGR1(3), IFNGR2(1), IKBKB(2), JAK2(3), LIN7A(2), NFKB1(2), RB1(7), RELA(2), TNFRSF1A(2), TNFRSF1B(1), USH1C(5), WT1(4)	4848186	35	31	35	5	6	8	10	3	8	0	0.054	1.00
24	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(12), EP300(6), LPL(3), NCOA1(5), NCOA2(9), RXRA(1)	4966378	36	33	35	14	6	14	7	3	6	0	0.055	1.00
25	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), HLCS(5), SPCS1(1), SPCS3(2)	845144	9	8	9	1	0	2	2	1	4	0	0.057	1.00
26	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	184	ACTB(1), ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), AKT1(1), AKT3(2), ARHGAP5(1), BCAR1(5), BIRC3(3), BRAF(7), CAPN2(2), CAV2(1), CAV3(1), CCND2(3), CCND3(1), CDC42(1), COL11A2(10), COL1A1(8), COL1A2(12), COL2A1(8), COL3A1(10), COL4A1(6), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(5), COL5A2(11), COL5A3(11), COL6A3(10), COMP(1), CTNNB1(3), DIAPH1(1), DOCK1(3), EGF(6), EGFR(6), ERBB2(1), FARP2(6), FIGF(1), FLNA(8), FLNB(3), FLNC(11), FLT1(8), FN1(16), FYN(3), GRLF1(11), HGF(6), HRAS(1), IBSP(4), IGF1(3), ILK(1), ITGA1(3), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGAV(3), ITGB1(3), ITGB3(3), ITGB4(6), ITGB6(1), ITGB7(1), ITGB8(3), JUN(3), LAMA1(12), LAMA2(18), LAMA3(7), LAMA4(13), LAMA5(6), LAMB1(5), LAMB2(2), LAMB3(1), LAMB4(3), LAMC1(8), LAMC2(2), LAMC3(1), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MET(3), MYL2(1), MYLK(5), MYLK2(2), MYLPF(1), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PARVB(1), PARVG(1), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(4), PDPK1(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP5K1C(1), PRKCA(4), PRKCG(8), PTK2(4), PXN(3), RAC1(1), RAF1(1), RAP1B(1), RAPGEF1(3), RELN(24), ROCK1(5), ROCK2(3), SHC1(1), SHC2(2), SHC3(2), SHC4(4), SOS1(6), SOS2(5), THBS1(1), THBS3(3), THBS4(1), TLN1(3), TLN2(11), TNC(11), TNXB(15), VASP(2), VAV1(7), VAV2(3), VAV3(1), VCL(2), VEGFC(4), VWF(15)	95801024	618	160	616	188	156	214	125	52	71	0	0.057	1.00
27	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	5	ARG1(2), ASL(3), GLS(2), GLUD1(4)	1178716	11	11	11	4	1	6	2	0	2	0	0.058	1.00
28	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(6), COL4A2(6), COL4A3(5), COL4A4(9), COL4A5(2), COL4A6(6), F10(3), F11(3), F12(1), F2R(2), F5(14), F8(9), F9(4), FGA(5), FGB(3), FGG(1), KLKB1(4), SERPINC1(5), SERPING1(1)	12073384	89	63	89	21	16	38	20	5	10	0	0.061	1.00
29	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	20	ANPEP(5), CD2(1), CD33(2), CD5(2), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12A(1), IL12B(2), IL4(2), ITGAX(9), TLR2(3), TLR7(3), TLR9(1)	4550748	35	32	34	10	9	14	6	2	4	0	0.063	1.00
30	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	ARAF(3), BRAF(7), CD244(2), CHP(2), FAS(1), FASLG(1), FCGR3A(3), FCGR3B(2), FYN(3), GZMB(1), HLA-B(1), HLA-C(1), HLA-G(1), HRAS(1), ICAM1(2), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), ITGAL(1), ITGB2(3), KIR2DL1(1), KIR2DL3(4), KIR3DL1(6), KIR3DL2(1), KLRC1(1), KLRC3(1), KRAS(1), LCK(2), LCP2(2), MAP2K1(2), MAPK1(1), MAPK3(1), NCR1(5), NCR2(1), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), PAK1(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRF1(1), PRKCA(4), PRKCG(8), PTPN11(2), RAC1(1), RAF1(1), SH2D1A(1), SHC1(1), SHC2(2), SHC3(2), SHC4(4), SOS1(6), SOS2(5), SYK(1), TNFRSF10A(1), TNFRSF10B(1), ULBP1(1), ULBP3(1), VAV1(7), VAV2(3), VAV3(1), ZAP70(2)	29957578	188	106	187	56	45	60	42	20	21	0	0.064	1.00
31	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(1), ESR1(5), GREB1(12), HSPB2(1), MTA1(1), MTA3(2), TUBA8(1)	3050208	24	24	24	10	9	7	6	1	1	0	0.069	1.00
32	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	162	ADCY1(7), ADCY3(4), ADCY4(3), ADCY7(4), ADCY8(13), ADCY9(3), ADORA2A(5), ADRA1A(2), ADRA1B(3), ADRA1D(2), ADRB2(3), AGTR1(2), ATP2A1(1), ATP2A2(3), ATP2A3(2), ATP2B1(3), ATP2B2(5), ATP2B3(2), ATP2B4(3), AVPR1A(3), AVPR1B(2), BDKRB1(1), BDKRB2(2), BST1(1), CACNA1A(7), CACNA1B(1), CACNA1C(12), CACNA1D(3), CACNA1E(14), CACNA1F(8), CACNA1G(5), CACNA1H(5), CACNA1I(8), CACNA1S(5), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CCKAR(2), CCKBR(1), CD38(1), CHP(2), CHRM2(6), CHRM3(4), CHRM5(2), CYSLTR1(2), CYSLTR2(1), DRD1(1), EDNRA(1), EDNRB(3), EGFR(6), ERBB2(1), ERBB3(3), ERBB4(9), F2R(2), GNA14(1), GNAL(1), GNAS(5), GRIN1(1), GRIN2A(13), GRIN2C(2), GRIN2D(2), GRM1(10), GRPR(2), HRH1(3), HRH2(1), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(3), HTR5A(3), HTR6(1), HTR7(3), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), LHCGR(7), LTB4R2(1), MYLK(5), MYLK2(2), NOS1(10), NOS3(1), NTSR1(3), OXTR(1), P2RX2(1), P2RX3(4), P2RX4(1), P2RX7(1), PDE1A(2), PDE1B(1), PDGFRA(8), PDGFRB(4), PHKA1(4), PHKA2(2), PHKB(6), PHKG1(2), PHKG2(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCD3(1), PLCE1(11), PLCG1(1), PLCG2(3), PLCZ1(4), PLN(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), PTAFR(3), PTGER3(5), PTGFR(2), RYR1(24), SLC8A3(3), SPHK2(1), TACR1(2), TACR3(3), TBXA2R(2), TNNC1(1), TRHR(1), TRPC1(4), VDAC1(1)	67460398	463	152	461	135	133	151	81	47	51	0	0.071	1.00
33	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(2), CNR2(2), DNMT1(3), MTNR1A(1), PTAFR(3), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), TBXA2R(2)	2971888	25	24	25	8	9	9	6	0	1	0	0.073	1.00
34	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	23	ABAT(2), ALDH4A1(3), ALDH5A1(1), CAD(8), EPRS(10), GAD1(4), GAD2(5), GCLC(2), GCLM(1), GLS(2), GLUD1(4), GLUL(2), GOT2(2), GPT(1), GPT2(2), GSS(2), NADSYN1(6), PPAT(2)	8058416	59	49	59	15	10	27	14	4	4	0	0.074	1.00
35	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT1(1), AKT3(2), BTK(4), FCER1A(2), FYN(3), HRAS(1), IL4(2), INPP5D(5), KRAS(1), LCP2(2), LYN(1), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), MS4A2(3), PDK1(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLCG1(1), PLCG2(3), PRKCA(4), PRKCD(2), PRKCE(3), RAC1(1), RAF1(1), SOS1(6), SOS2(5), SYK(1), VAV1(7), VAV2(3), VAV3(1)	18967146	119	84	119	30	28	37	23	13	18	0	0.075	1.00
36	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(1), AGTR1(2), AGTR2(3), CMA1(2), COL4A1(6), COL4A2(6), COL4A3(5), COL4A4(9), COL4A5(2), COL4A6(6)	6924734	45	41	45	14	10	22	7	0	6	0	0.082	1.00
37	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(7), ADRB2(3), CFTR(5), GNAS(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	3468864	28	25	28	8	9	7	6	3	3	0	0.086	1.00
38	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(7), GNAS(5), GNB1(1), PRKAR1A(2)	1804742	15	15	15	5	4	5	3	2	1	0	0.091	1.00
39	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), JAK2(3), STAT4(4), TYK2(5)	3830026	26	25	26	7	4	7	7	2	6	0	0.093	1.00
40	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	32	ALDH4A1(3), ARG1(2), ASL(3), CKB(1), CKM(2), CKMT2(1), DAO(1), EPRS(10), GATM(1), GLUD1(4), GOT2(2), LAP3(1), NOS1(10), NOS3(1), OTC(2), P4HA1(2), P4HA2(2), P4HA3(3), PARS2(2), RARS(4), RARS2(2)	8582448	59	50	59	15	10	24	13	2	10	0	0.097	1.00
41	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	14	ACOX1(2), ACOX3(4), FADS2(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5)	2684774	23	21	23	3	5	6	6	3	3	0	0.097	1.00
42	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(9), BST1(1), CD38(1), ENPP1(7), ENPP3(3), NADSYN1(6), NMNAT2(2), NNT(7), NT5C1A(2), NT5C1B(1), NT5C2(2), NT5C3(3), NT5E(2), NUDT12(2)	5841960	48	38	48	10	10	20	9	4	5	0	0.097	1.00
43	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	35	ACTA1(1), ACTN2(6), ACTN3(2), ACTN4(4), DES(2), DMD(21), FAM48A(1), MYBPC1(8), MYBPC3(3), MYH3(4), MYH6(11), MYH7(8), MYL1(3), MYL2(1), MYL3(2), MYOM1(9), NEB(20), TNNI2(1), TNNI3(1), TNNT1(1), TNNT2(2), TNNT3(3), TPM3(1), VIM(4)	16816728	119	77	119	47	34	33	25	10	17	0	0.10	1.00
44	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCL3(2), CCR1(2), CCR3(1), CCR4(3), CD4(1), CXCR3(1), CXCR4(5), IFNG(1), IFNGR1(3), IFNGR2(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL18R1(2), IL4(2), IL4R(1), TGFB1(1), TGFB2(2)	5101124	37	32	37	13	8	12	9	0	8	0	0.10	1.00
45	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT1(1), AKT3(2), BRAF(7), CAB39(1), DDIT4(2), EIF4B(4), FIGF(1), HIF1A(1), IGF1(3), MAPK1(1), MAPK3(1), PDPK1(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PRKAA2(3), RICTOR(3), RPS6(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA6(4), RPS6KB1(1), STK11(3), TSC1(5), TSC2(5), ULK1(1), ULK2(2), VEGFC(4)	14056126	85	67	84	23	15	25	22	8	15	0	0.11	1.00
46	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	10	DNM1(1), GABRA1(6), GABRA3(4), GABRA4(3), GABRA5(4), GPHN(1), NSF(2), UBQLN1(1)	2732656	22	20	22	6	6	10	4	0	2	0	0.11	1.00
47	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(1), EGF(6), EGFR(6), HRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), PTPRB(13), RAF1(1), RASA1(5), SHC1(1), SOS1(6)	6589916	44	39	43	7	11	13	8	3	9	0	0.11	1.00
48	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(5), AGT(1), AGTR2(3), EDNRA(1), EDNRB(3), EGF(6), EGFR(6), FOS(1), HRAS(1), JUN(3), MYC(1), NFKB1(2), PLCG1(1), PRKCA(4), RELA(2)	5560898	40	34	38	11	8	13	7	4	8	0	0.12	1.00
49	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	29	ABAT(2), ADC(1), ALDH4A1(3), ALDH5A1(1), CAD(8), EARS2(2), EPRS(10), GAD1(4), GAD2(5), GCLC(2), GCLM(1), GFPT2(1), GLS(2), GLUD1(4), GLUL(2), GOT2(2), GPT(1), GPT2(2), GSR(2), GSS(2), NADSYN1(6), PPAT(2)	9483306	65	53	65	19	10	30	15	6	4	0	0.13	1.00
50	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(7), AKT1(1), CAMK2B(2), CAMK2D(1), CREB1(1), GNAS(5), HRAS(1), MAPK1(1), MAPK14(1), MAPK3(1), PIK3R1(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), RAC1(1), RPS6KA1(2), RPS6KA5(4), SOS1(6)	7232318	47	41	47	10	11	11	14	6	5	0	0.13	1.00
51	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	6	EPX(4), GBA3(6), LPO(2), MPO(3), PRDX6(1)	1850310	16	14	16	5	2	4	9	0	1	0	0.13	1.00
52	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	7	CPN2(1), CYP11A1(2), CYP17A1(1), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(3)	1585268	15	13	15	4	3	7	3	1	1	0	0.13	1.00
53	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), DRD1(1), DRD2(2), EGF(6), EGFR(6), GJA1(4), GJD2(2), GNAI1(2), GNAI3(1), GNAS(5), GRM1(10), GUCY1A3(5), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(4), HRAS(1), HTR2A(1), HTR2B(1), HTR2C(2), ITPR1(4), ITPR2(11), ITPR3(1), KRAS(1), MAP2K1(2), MAP2K5(1), MAPK1(1), MAPK3(1), MAPK7(1), NPR1(2), NPR2(2), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(4), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKG1(4), PRKG2(3), PRKX(1), RAF1(1), SOS1(6), SOS2(5), TJP1(8), TUBA1B(1), TUBA3C(5), TUBA3D(2), TUBA3E(3), TUBA8(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(2), TUBB4(4), TUBB4Q(1), TUBB8(1)	34514378	223	116	222	60	62	68	45	22	26	0	0.13	1.00
54	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	71	ARAF(3), BRAF(7), C7orf16(1), CACNA1A(7), CRHR1(2), GNA12(1), GNAI1(2), GNAI3(1), GNAS(5), GNAZ(2), GRIA1(6), GRIA2(3), GRIA3(8), GRID2(12), GRM1(10), GUCY1A3(5), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(4), HRAS(1), IGF1(3), ITPR1(4), ITPR2(11), ITPR3(1), KRAS(1), LYN(1), MAP2K1(2), MAPK1(1), MAPK3(1), NOS1(10), NOS3(1), NPR1(2), NPR2(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(4), PRKCG(8), PRKG1(4), PRKG2(3), RAF1(1), RYR1(24)	29281178	216	105	216	61	51	75	43	19	28	0	0.14	1.00
55	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(5), AASDHPPT(1), AASS(6), KARS(2)	1862592	15	15	15	5	2	5	4	2	2	0	0.15	1.00
56	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(5), FYN(3), LRP8(1), RELN(24)	3755444	34	25	34	9	7	9	10	7	1	0	0.15	1.00
57	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), CREBBP(12), DFFB(2), GZMA(4), GZMB(1), PRF1(1)	2860104	21	20	21	9	6	6	3	2	4	0	0.15	1.00
58	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	81	AGRN(1), CD36(1), CD44(3), CD47(2), COL11A2(10), COL1A1(8), COL1A2(12), COL2A1(8), COL3A1(10), COL4A1(6), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(5), COL5A2(11), COL5A3(11), COL6A3(10), DAG1(1), FN1(16), FNDC1(7), FNDC3A(1), GP1BA(2), GP5(3), GP6(2), GP9(1), HMMR(1), HSPG2(7), IBSP(4), ITGA1(3), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGAV(3), ITGB1(3), ITGB3(3), ITGB4(6), ITGB6(1), ITGB7(1), ITGB8(3), LAMA1(12), LAMA2(18), LAMA3(7), LAMA4(13), LAMA5(6), LAMB1(5), LAMB2(2), LAMB3(1), LAMB4(3), LAMC1(8), LAMC2(2), LAMC3(1), RELN(24), SDC1(1), SDC2(2), SDC3(1), SV2A(2), SV2B(4), SV2C(3), THBS1(1), THBS3(3), THBS4(1), TNC(11), TNXB(15), VWF(15)	57982788	380	140	380	111	99	137	80	21	43	0	0.16	1.00
59	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(2), GLS(2), GLUD1(4)	1445894	11	11	11	5	1	7	2	0	1	0	0.17	1.00
60	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	40	ADCY3(4), ADCY9(3), ARF1(1), ARF5(3), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V1A(3), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ERO1L(1), GNAS(5), PDIA4(1), PLCG1(1), PLCG2(3), PRKCA(4), SEC61A1(2), SEC61A2(1), TRIM23(2)	9803528	55	49	55	16	12	15	17	5	6	0	0.18	1.00
61	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), DRD1(1), DRD2(2), GRM1(10), PLCB1(6), PPP1R1B(1), PPP3CA(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	4232840	31	27	31	8	10	11	4	3	3	0	0.20	1.00
62	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(7), CD3D(1), CD4(1), CREBBP(12), GNAS(5), GNB1(1), HLA-DRA(1), HLA-DRB1(1), LCK(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(3), ZAP70(2)	6185678	44	37	44	18	11	17	5	5	6	0	0.20	1.00
63	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(7), CD3D(1), CD4(1), CREBBP(12), GNAS(5), GNB1(1), HLA-DRA(1), HLA-DRB1(1), LCK(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(3), ZAP70(2)	6185678	44	37	44	18	11	17	5	5	6	0	0.20	1.00
64	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(1), UGDH(2), UGP2(4), UXS1(3)	1352088	11	10	11	0	0	4	4	1	2	0	0.20	1.00
65	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(3), EGF(6), EGFR(6), MET(3), PDGFRA(8), PRKCA(4), SH3GLB1(1), SH3KBP1(4)	5214866	36	32	35	6	10	12	6	3	5	0	0.20	1.00
66	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	6	ADCY1(7), CREM(2), FSHB(1), GNAS(5), XPO1(2)	2218948	17	16	17	8	5	4	3	4	1	0	0.20	1.00
67	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(3)	435032	4	4	4	1	1	1	2	0	0	0	0.21	1.00
68	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	52	AKR1C4(1), AKR1D1(4), ARSD(1), ARSE(2), CARM1(1), CYP19A1(4), HSD11B1(3), HSD11B2(1), HSD17B1(1), HSD17B12(1), HSD17B7(1), HSD3B1(4), HSD3B2(3), LCMT1(2), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), SRD5A1(2), SRD5A2(2), STS(3), SULT1E1(1), SULT2A1(3), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2), WBSCR22(3)	12450566	88	63	88	13	26	25	20	8	9	0	0.21	1.00
69	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(3), NR0B2(1), NR1H3(2), NR1H4(2), RXRA(1)	1464406	10	10	10	3	2	3	2	1	2	0	0.21	1.00
70	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	79	ANPEP(5), CD14(1), CD19(2), CD1A(4), CD1C(5), CD1D(3), CD1E(4), CD2(1), CD22(5), CD33(2), CD34(2), CD36(1), CD37(2), CD38(1), CD3D(1), CD4(1), CD44(3), CD5(2), CD8B(1), CD9(1), CR1(4), CR2(9), CSF1(2), CSF1R(3), CSF3R(5), DNTT(2), EPOR(2), FCER2(1), FCGR1A(1), FLT3(4), GP1BA(2), GP5(3), GP9(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), IL11RA(1), IL1B(1), IL1R2(3), IL4(2), IL4R(1), IL5RA(2), IL6R(1), IL7R(2), ITGA1(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGAM(3), ITGB3(3), KIT(5), MME(8), MS4A1(2), TFRC(2)	21244300	142	89	142	60	35	61	25	4	17	0	0.21	1.00
71	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(9), PDXP(1), PSAT1(1)	1306342	11	10	11	2	1	4	2	3	1	0	0.22	1.00
72	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(2), CR1(4), CR2(9), FCGR2B(2), HLA-DRA(1), HLA-DRB1(1), ICAM1(2), ITGAL(1), ITGB2(3), PTPRC(3)	4122124	28	26	28	13	7	9	4	5	3	0	0.22	1.00
73	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	28	AKR1C4(1), AKR1D1(4), ARSB(1), ARSD(1), ARSE(2), HSD11B1(3), HSD11B2(1), HSD3B1(4), HSD3B2(3), SRD5A1(2), SRD5A2(2), STS(3), SULT1E1(1), SULT2A1(3), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2B15(1), UGT2B4(4)	6510528	47	37	47	7	11	14	12	4	6	0	0.23	1.00
74	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(2), FOS(1), HRAS(1), INSR(7), IRS1(3), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PIK3R1(1), PTPN11(2), RAF1(1), RASA1(5), SHC1(1), SLC2A4(2), SOS1(6), SRF(2)	6296750	42	36	41	7	10	13	8	5	6	0	0.24	1.00
75	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	133	ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), ADRA1A(2), ADRA1B(3), ADRA1D(2), ADRB2(3), ANXA6(4), ARRB1(2), ATP1A4(3), ATP1B2(1), ATP2A2(3), ATP2A3(2), ATP2B1(3), ATP2B2(5), ATP2B3(2), CACNA1A(7), CACNA1B(1), CACNA1C(12), CACNA1D(3), CACNA1E(14), CACNA1S(5), CACNB3(2), CALR(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CASQ1(1), CASQ2(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), GJA1(4), GJB2(1), GJB4(1), GNAI3(1), GNAZ(2), GNB1(1), GNB2(2), GNB4(2), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK6(1), ITPR1(4), ITPR2(11), ITPR3(1), KCNB1(1), KCNJ5(2), MIB1(2), NME7(2), PEA15(1), PLCB3(3), PLN(1), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCQ(4), PRKD1(9), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS20(1), RGS3(4), RGS5(1), RGS6(4), RGS9(2), RYR1(24), SFN(2), SLC8A3(3), USP5(1), YWHAB(1), YWHAQ(1)	44979888	275	119	274	84	71	105	44	23	32	0	0.24	1.00
76	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	134924	1	1	1	0	0	0	1	0	0	0	0.25	1.00
77	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(1), PIK3R1(1), PLCB1(6), PLCG1(1), PRKCA(4), VAV1(7)	2863130	20	19	20	5	7	5	3	4	1	0	0.25	1.00
78	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	CREB1(1), FOS(1), JUN(3), MAPK1(1), MAPK14(1), MAPK8(2), PRKCA(4)	1727846	13	13	12	2	5	3	3	1	1	0	0.25	1.00
79	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(12), GNA12(1), PRKACB(2), PRKACG(1), PRKAR2B(2)	2728562	18	18	18	5	4	8	3	2	1	0	0.25	1.00
80	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(9), CDH1(3), CREBBP(12), EP300(6), MAP2K1(2), MAP3K7(2), MAPK3(1), TGFB1(1), TGFB2(2), TGFBR2(3)	6897500	41	38	40	11	6	16	10	3	6	0	0.26	1.00
81	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1B(3), ACVRL1(3), AKT1(1), BMPR1A(3), BUB1(3), CDKL2(2), CDS1(2), CLK1(1), CLK2(1), CLK4(2), COL4A3BP(3), CSNK2A1(2), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKZ(3), IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(3), ITPKA(1), ITPKB(4), MOS(4), NEK1(3), OCRL(5), PAK4(1), PIK3C2A(4), PIK3C2B(6), PIK3C2G(6), PIK3CB(2), PIK3CG(9), PIM2(2), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCG1(1), PLCG2(3), PLK3(3), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCQ(4), PRKD1(9), PRKG1(4), RAF1(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA4(1), RPS6KB1(1), STK11(3), VRK1(1)	30579510	188	102	187	47	54	55	38	15	26	0	0.26	1.00
82	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CKS1B(1), CUL1(2), E2F1(2), RB1(7), RBX1(1), SKP2(1), UBE2M(1)	2348354	15	14	15	1	2	6	0	1	6	0	0.26	1.00
83	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), HLA-DRA(1), HLA-DRB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL18R1(2), IL4(2), IL4R(1)	3417422	22	20	22	8	3	7	6	0	6	0	0.27	1.00
84	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	123	ABL1(2), ABLIM1(2), ABLIM2(2), ABLIM3(1), ARHGEF12(3), CDC42(1), CDK5(1), CFL1(2), CFL2(1), CHP(2), CXCR4(5), DCC(12), DPYSL2(1), DPYSL5(6), EFNA3(1), EFNB1(2), EFNB2(1), EPHA1(3), EPHA2(1), EPHA3(6), EPHA4(1), EPHA6(9), EPHA7(7), EPHA8(4), EPHB2(4), EPHB3(6), EPHB4(2), EPHB6(3), FYN(3), GNAI1(2), GNAI3(1), HRAS(1), ITGB1(3), KRAS(1), L1CAM(2), LIMK2(2), MAPK1(1), MAPK3(1), MET(3), NCK1(2), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NGEF(1), NRP1(5), NTN1(2), NTN4(1), NTNG1(1), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PLXNA1(6), PLXNA2(2), PLXNA3(3), PLXNB1(3), PLXNB3(3), PLXNC1(8), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PTK2(4), RAC1(1), RASA1(5), RGS3(4), ROBO1(6), ROBO2(6), ROBO3(4), ROCK1(5), ROCK2(3), SEMA3A(3), SEMA3B(1), SEMA3C(5), SEMA3D(2), SEMA3E(3), SEMA3F(3), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(2), SEMA4D(1), SEMA4F(5), SEMA5A(7), SEMA5B(4), SEMA6C(5), SEMA6D(6), SEMA7A(1), SLIT1(4), SLIT2(10), SLIT3(8), SRGAP1(2), SRGAP2(4), SRGAP3(3), UNC5B(2), UNC5C(6)	52273082	304	130	304	118	64	105	62	28	45	0	0.27	1.00
85	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(5), ESR2(1), ITPKA(1), PDE1A(2), PDE1B(1), PLCB1(6), PLCB2(5), PRL(1), VIP(1)	3042376	23	21	23	8	10	7	3	2	1	0	0.27	1.00
86	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2	FAH(1), GSTZ1(2)	353152	3	3	3	1	1	0	0	1	1	0	0.27	1.00
87	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(5), P2RY1(2), P2RY2(1), P2RY6(1)	1601110	12	11	12	4	5	5	1	0	1	0	0.27	1.00
88	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(2), C1QB(2), C1R(2), C1S(2), C2(1), C3(3), C5(1), C7(7), C8A(3), C9(1), MASP1(9), MASP2(1), MBL2(3)	5353528	37	31	37	13	7	15	9	3	3	0	0.28	1.00
89	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(7), AKT1(1), BAX(1), BCL2L1(1), CSF2RB(5), IGF1(3), KIT(5), PIK3R1(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	5036332	32	30	32	6	9	13	4	3	3	0	0.28	1.00
90	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	26	ACTA1(1), AKT1(1), BDKRB2(2), CHRNA1(1), FLT1(8), FLT4(3), NOS3(1), PDE2A(2), PDE3A(4), PDE3B(3), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKG1(4), PRKG2(3), SLC7A1(4), SYT1(3)	7779846	48	41	48	26	12	13	9	7	7	0	0.28	1.00
91	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(1), CD80(2), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL4(2)	1077612	8	8	8	3	0	3	2	1	2	0	0.28	1.00
92	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(5), ABAT(2), ACY3(2), ADSL(1), ADSS(1), ADSSL1(1), AGXT2(1), ASL(3), ASNS(3), CAD(8), DARS(1), DARS2(5), DDO(2), DLAT(1), DLD(2), GAD1(4), GAD2(5), GOT2(2), GPT(1), GPT2(2), NARS(2), NARS2(2), PC(2), PDHA1(2), PDHA2(5)	10270600	66	53	66	21	13	29	11	6	7	0	0.28	1.00
93	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	133	ACTA1(1), ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), ARRB1(2), ATF2(2), ATP2A2(3), ATP2A3(2), CACNB3(2), CAMK2B(2), CAMK2D(1), CNN1(2), CORIN(8), CREB3(2), CRHR1(2), DGKZ(3), FOS(1), GABPA(2), GABPB2(1), GJA1(4), GNB1(1), GNB2(2), GNB4(2), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK6(1), GSTO1(1), GUCY1A3(5), IGFBP3(1), IGFBP6(1), IL1B(1), ITPR1(4), ITPR2(11), ITPR3(1), JUN(3), MIB1(2), MYL2(1), MYLK2(2), NFKB1(2), NOS1(10), NOS3(1), OXTR(1), PDE4B(3), PDE4D(1), PLCB3(3), PLCG1(1), PLCG2(3), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCQ(4), PRKD1(9), RAMP2(1), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS20(1), RGS3(4), RGS5(1), RGS6(4), RGS9(2), RYR1(24), SFN(2), SP1(1), TNXB(15), USP5(1), YWHAB(1), YWHAQ(1)	41029356	241	116	239	73	69	88	40	15	29	0	0.29	1.00
94	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CUL1(2), E2F1(2), RB1(7)	1838028	11	11	11	1	0	6	0	0	5	0	0.29	1.00
95	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	28	B3GNT6(1), B4GALT5(2), C1GALT1C1(1), GALNT1(1), GALNT10(1), GALNT11(2), GALNT12(3), GALNT14(3), GALNT2(2), GALNT3(2), GALNT5(6), GALNT6(2), GALNT8(2), GALNTL1(3), GALNTL4(3), GALNTL5(3), GCNT1(2), GCNT3(2), OGT(2), ST3GAL1(1), ST6GALNAC1(3)	8069986	47	44	46	13	8	19	14	3	3	0	0.29	1.00
96	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(2), UGDH(2), UGP2(4), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2)	6739792	43	39	43	9	10	12	15	3	3	0	0.30	1.00
97	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(9), CREBBP(12), CTNNB1(3), DVL1(3), EP300(6), FZD1(1), HDAC1(2), LEF1(3), PITX2(3), TRRAP(11)	8810288	53	46	52	12	9	16	17	3	8	0	0.30	1.00
98	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	3	GLS(2), GLUD1(4)	848170	6	6	6	2	1	3	1	0	1	0	0.30	1.00
99	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), GOT2(2), TAT(1), TYR(3)	1255434	8	8	8	2	2	4	0	1	1	0	0.30	1.00
100	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IFNG(1), IL12A(1), IL12B(2)	802958	5	5	5	1	0	1	2	0	2	0	0.30	1.00
101	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(4), HDC(3), PNMT(2), TH(1), TPH1(1)	1656468	12	11	12	2	2	6	2	1	1	0	0.31	1.00
102	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), RB1(7), SP1(1), SP3(1)	1794596	10	10	10	1	1	3	0	0	6	0	0.31	1.00
103	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(1), AASS(6), KARS(2)	1265758	10	10	10	3	2	4	3	0	1	0	0.32	1.00
104	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	42	ABP1(4), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH4A1(3), ALDH9A1(2), AMD1(1), AOC2(1), AOC3(3), ARG1(2), ASL(3), CKB(1), CKM(2), CKMT2(1), DAO(1), GATM(1), GLUD1(4), GOT2(2), NOS1(10), NOS3(1), ODC1(1), OTC(2), P4HA1(2), P4HA2(2), P4HA3(3), RARS(4), SMS(2)	11077830	64	55	64	19	14	25	11	4	10	0	0.32	1.00
105	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(2), CAPN2(2), CAPNS2(1), CXCR3(1), EGF(6), EGFR(6), HRAS(1), ITGA1(3), ITGB1(3), MAPK1(1), MAPK3(1), MYL2(1), MYLK(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTK2(4), PXN(3), TLN1(3)	8846956	52	46	51	13	15	16	7	7	7	0	0.33	1.00
106	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA4(1), ANXA5(2), ANXA6(4), CYP11A1(2), EDNRA(1), EDNRB(3), HSD11B1(3), HSD11B2(1), PLA2G4A(5), PRL(1), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), PTGS1(2), TBXAS1(2)	5652568	39	33	39	15	8	14	8	3	6	0	0.33	1.00
107	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(7), AP2A1(2), AP2M1(1), DNM1(1), EPN1(2), EPS15(4), PICALM(4), PPP3CA(2), PPP3CB(4), PPP3CC(2), SYNJ1(2), SYNJ2(3), SYT1(3)	6051110	37	34	37	9	11	8	6	5	7	0	0.33	1.00
108	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(2)	579390	4	4	4	0	1	1	1	1	0	0	0.34	1.00
109	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), CFL1(2), GNAS(5), GNB1(1), HRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(1), NOX1(2), PIK3C2G(6), PLCB1(6), PPP1R12B(4), PRKCA(4), PTK2(4), RAF1(1), ROCK2(3)	6923488	45	39	45	14	12	18	8	3	4	0	0.35	1.00
110	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	192952	1	1	1	0	0	0	0	0	1	0	0.35	1.00
111	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(7), CREB1(1), CREB3(2), CREB5(3), DUSP4(2), DUSP6(1), DUSP9(2), EEF2K(3), MAP2K1(2), MAPK1(1), MAPK3(1), MKNK2(1), MOS(4), NFKB1(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), SHC1(1), SOS1(6), SOS2(5), TRAF3(1)	8109146	51	42	50	11	8	13	17	3	10	0	0.35	1.00
112	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(9), CREBBP(12), CSNK1A1(2), CSNK2A1(2), CTBP1(1), CTNNB1(3), DVL1(3), FZD1(1), HDAC1(2), MAP3K7(2), MYC(1), NLK(2), PPARD(1), TLE1(4), WIF1(3)	7875610	48	41	48	10	11	14	11	5	7	0	0.35	1.00
113	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	17	CALCR(5), CALCRL(3), CRHR1(2), CRHR2(2), EMR1(9), EMR2(4), GHRHR(3), GLP1R(1), GLP2R(3), GPR64(3), LPHN1(1), LPHN2(6)	6101662	42	34	42	16	11	12	10	4	5	0	0.35	1.00
114	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(12), EP300(6), ESR1(5), MAPK1(1), MAPK3(1)	4039354	25	24	24	6	5	9	6	2	3	0	0.36	1.00
115	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(7), GNAS(5), GNB1(1), PRKAA2(3), PRKACB(2), PRKACG(1), PRKAG2(4), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	4084922	28	24	28	7	8	9	5	3	3	0	0.36	1.00
116	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOA(1), ALDOB(2), TPI1(3)	1036850	7	7	7	3	2	2	3	0	0	0	0.37	1.00
117	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT3(3), FUT5(4), FUT6(2)	1397656	9	8	9	2	2	3	3	1	0	0	0.37	1.00
118	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), GPI(5), HK1(3), PFKL(2), PGK1(1), PKLR(3), TPI1(3)	2381818	19	15	19	4	6	5	5	0	3	0	0.37	1.00
119	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(6), EGFR(6), ERBB3(3), NRG1(3), UBE2D1(1)	2762204	19	17	18	4	6	6	3	1	3	0	0.38	1.00
120	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(2), C1QB(2), C1R(2), C1S(2), C2(1), C3(3), C5(1), C7(7), C8A(3), C8B(2), C9(1), MASP1(9)	5207568	35	29	35	15	8	13	9	3	2	0	0.38	1.00
121	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(3)	455858	3	3	3	0	0	2	1	0	0	0	0.39	1.00
122	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(7), CAP1(2), CCNB1(1), CDC25C(1), GNAI1(2), GNAS(5), GNB1(1), HRAS(1), MAPK1(1), MAPK3(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RPS6KA1(2)	5515508	33	30	33	12	7	11	7	6	2	0	0.39	1.00
123	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12A(1), IL12B(2), IL16(5), IL4(2), LTA(2)	2643656	16	16	16	4	3	4	5	3	1	0	0.39	1.00
124	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	BLVRA(2), CP(2), CPOX(2), EARS2(2), EPRS(10), FECH(2), FTH1(2), FTMT(4), GUSB(2), MMAB(1), PPOX(1), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2), UROD(1)	10816526	66	54	66	14	14	22	19	5	6	0	0.39	1.00
125	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	20	ASNS(3), CA12(2), CA14(1), CA3(2), CA4(1), CA5A(1), CA5B(2), CA6(2), CA7(1), CA9(1), GLS(2), GLUD1(4), GLUL(2)	4193680	24	24	24	2	6	9	6	1	2	0	0.40	1.00
126	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG7(4), BECN1(1), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNG(1), PIK3C3(3), PIK3R4(5), PRKAA2(3), ULK1(1), ULK2(2)	5718962	34	30	33	9	10	8	12	1	3	0	0.41	1.00
127	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(1)	506410	3	3	3	0	0	1	1	1	0	0	0.41	1.00
128	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(5), AMY2B(3), ENPP1(7), ENPP3(3), G6PC(2), GANAB(5), GBA3(6), GBE1(1), GCK(1), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(3), HK2(5), HK3(5), MGAM(3), PYGB(3), PYGM(4), UGDH(2), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2B15(1), UGT2B4(4), UXS1(3)	14193898	89	63	89	25	22	32	21	6	8	0	0.41	1.00
129	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	65	A2M(4), BDKRB1(1), BDKRB2(2), C1QA(2), C1QB(2), C1R(2), C1S(2), C2(1), C3(3), C3AR1(1), C4BPA(1), C5(1), C5AR1(1), C7(7), C8A(3), C8B(2), C9(1), CD46(2), CFB(1), CFH(4), CFI(2), CPB2(2), CR1(4), CR2(9), F10(3), F11(3), F12(1), F13A1(3), F2R(2), F3(1), F5(14), F8(9), F9(4), FGA(5), FGB(3), FGG(1), KLKB1(4), KNG1(4), MASP1(9), MASP2(1), MBL2(3), PLAT(1), PLAU(2), PLG(1), SERPINA1(1), SERPINA5(1), SERPINC1(5), SERPIND1(1), SERPINF2(3), SERPING1(1), VWF(15)	23717254	161	90	161	54	34	55	41	16	15	0	0.41	1.00
130	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGT(1), AGTR1(2), AGTR2(3), BDKRB2(2), KNG1(4), NOS3(1)	2766476	17	16	17	10	3	6	4	2	2	0	0.42	1.00
131	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(1), CYP2A6(4), NAT2(1), XDH(8)	2131550	15	13	15	6	4	6	2	1	2	0	0.42	1.00
132	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(2), ACTB(1), ARHGEF2(5), CD14(1), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(3), CTTN(2), FYN(3), HCLS1(3), ITGB1(3), KRT18(2), NCK1(2), NCL(1), PRKCA(4), ROCK1(5), ROCK2(3), TLR5(2), TUBA1B(1), TUBA3C(5), TUBA3D(2), TUBA3E(3), TUBA8(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(2), TUBB4(4), TUBB4Q(1), TUBB8(1), WAS(4), WASL(2), YWHAQ(1)	13876346	79	60	79	16	16	27	17	9	10	0	0.42	1.00
133	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(2), ACTB(1), ARHGEF2(5), CD14(1), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(3), CTTN(2), FYN(3), HCLS1(3), ITGB1(3), KRT18(2), NCK1(2), NCL(1), PRKCA(4), ROCK1(5), ROCK2(3), TLR5(2), TUBA1B(1), TUBA3C(5), TUBA3D(2), TUBA3E(3), TUBA8(1), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(2), TUBB4(4), TUBB4Q(1), TUBB8(1), WAS(4), WASL(2), YWHAQ(1)	13876346	79	60	79	16	16	27	17	9	10	0	0.42	1.00
134	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	8	CYP17A1(1), HSD17B1(1), HSD17B4(1), HSD17B7(1), HSD3B1(4), HSD3B2(3)	1825212	11	11	11	2	3	3	2	2	1	0	0.42	1.00
135	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(1), HRAS(1), KLK2(1), NTRK1(3), PIK3R1(1), PLCG1(1), PRKCA(4), SHC1(1), SOS1(6)	3626928	19	19	19	5	3	5	6	2	3	0	0.42	1.00
136	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(2), F13A1(3), F2R(2), FGA(5), FGB(3), FGG(1), PLAT(1), PLAU(2), PLG(1), SERPINB2(3)	3573172	23	21	23	7	3	10	8	0	2	0	0.42	1.00
137	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	202	ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), APC(9), APC2(2), ARAF(3), ARHGEF1(2), ARHGEF12(3), ARHGEF4(3), ARHGEF6(2), ARHGEF7(3), ARPC1A(2), BCAR1(5), BDKRB1(1), BDKRB2(2), BRAF(7), CD14(1), CDC42(1), CFL1(2), CFL2(1), CHRM2(6), CHRM3(4), CHRM4(1), CHRM5(2), CYFIP1(4), CYFIP2(6), DIAPH1(1), DIAPH2(1), DIAPH3(5), DOCK1(3), EGF(6), EGFR(6), F2R(2), FGD1(3), FGD3(2), FGF10(2), FGF12(3), FGF14(1), FGF2(2), FGF23(1), FGF3(1), FGF5(2), FGF6(2), FGF8(1), FGFR1(1), FGFR2(3), FGFR3(2), FGFR4(1), FN1(16), GIT1(1), GNA12(1), GNG12(1), GRLF1(11), GSN(2), HRAS(1), IQGAP1(6), IQGAP2(6), IQGAP3(9), ITGA1(3), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGAD(6), ITGAE(3), ITGAL(1), ITGAM(3), ITGAV(3), ITGAX(9), ITGB1(3), ITGB2(3), ITGB3(3), ITGB4(6), ITGB6(1), ITGB7(1), ITGB8(3), KRAS(1), LIMK2(2), MAP2K1(2), MAPK1(1), MAPK3(1), MOS(4), MRAS(2), MSN(3), MYH10(1), MYH14(4), MYH9(12), MYL2(1), MYLK(5), MYLK2(2), MYLPF(1), NCKAP1(4), NCKAP1L(8), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PDGFB(1), PDGFRA(8), PDGFRB(4), PFN2(1), PFN3(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(1), PPP1R12B(4), PTK2(4), PXN(3), RAC1(1), RAF1(1), RDX(1), ROCK1(5), ROCK2(3), RRAS2(2), SCIN(1), SLC9A1(3), SOS1(6), SOS2(5), SSH1(1), SSH2(6), TIAM1(8), TIAM2(3), VAV1(7), VAV2(3), VAV3(1), VCL(2), WAS(4), WASL(2)	75493894	458	146	456	135	92	160	96	48	62	0	0.42	1.00
138	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(1), GPR109B(2), GPR161(1), GPR171(2), GPR18(1), GPR34(1), GPR39(1), GPR45(4), GPR65(1), GPR68(1), GPR75(2)	2642232	19	16	19	6	7	7	4	0	1	0	0.43	1.00
139	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(5), GOT2(2), LDHB(2), LDHC(1)	1840164	10	10	10	2	0	3	3	2	2	0	0.43	1.00
140	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREB1(1), CREBBP(12), EP300(6), NCOA3(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RARA(1), RXRA(1)	5467804	34	29	33	10	7	14	4	5	4	0	0.44	1.00
141	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2R(2), F3(1), F5(14), FGA(5), FGB(3), FGG(1), SERPINC1(5)	4394464	34	25	34	7	3	13	13	3	2	0	0.44	1.00
142	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	22	ASNS(3), CA12(2), CA13(1), CA14(1), CA3(2), CA4(1), CA5A(1), CA5B(2), CA6(2), CA7(1), CA9(1), GLS(2), GLUD1(4), GLUL(2)	4508384	25	25	25	2	6	10	6	1	2	0	0.44	1.00
143	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CSAD(1), GAD1(4), GAD2(5), GGT1(1)	1577970	13	10	13	8	4	6	2	1	0	0	0.44	1.00
144	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	9	ACTA1(1), EPHA4(1), FYN(3), ITGA1(3), ITGB1(3), L1CAM(2), LYN(1), RAP1B(1), SELP(8)	3687448	23	21	23	12	6	3	6	1	7	0	0.44	1.00
145	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(2), BCR(1), BLNK(1), FOS(1), HRAS(1), JUN(3), LYN(1), MAP2K1(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8IP3(3), PAPPA(8), RAC1(1), RPS6KA1(2), RPS6KA3(1), SHC1(1), SOS1(6), SYK(1), VAV1(7), VAV2(3), VAV3(1)	8747988	50	44	49	10	10	14	16	6	4	0	0.45	1.00
146	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(7), CREB1(1), CREB3(2), CREB5(3), MAPK1(1), RAF1(1), SNX13(4)	3132622	19	18	19	6	5	3	8	0	3	0	0.45	1.00
147	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	123	ACTB(1), ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), AKT1(1), AKT3(2), AMOTL1(3), ASH1L(7), CASK(1), CDC42(1), CGN(4), CLDN1(2), CLDN10(4), CLDN16(4), CLDN17(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN6(1), CLDN8(1), CLDN9(3), CSDA(2), CSNK2A1(2), CTNNB1(3), CTTN(2), EPB41(2), EPB41L1(1), EPB41L2(1), EXOC3(2), EXOC4(2), F11R(1), GNAI1(2), GNAI3(1), HCLS1(3), HRAS(1), IGSF5(2), INADL(9), KRAS(1), LLGL1(1), LLGL2(2), MAGI1(5), MAGI2(7), MAGI3(1), MLLT4(1), MPDZ(4), MPP5(2), MRAS(2), MYH1(13), MYH10(1), MYH11(7), MYH13(8), MYH14(4), MYH15(10), MYH3(4), MYH6(11), MYH7(8), MYH7B(4), MYH9(12), MYL2(1), MYLPF(1), PARD3(5), PARD6A(1), PPM1J(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(2), PPP2R4(1), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCI(4), PRKCQ(4), RAB3B(1), RRAS2(2), SPTAN1(2), SYMPK(6), TJAP1(4), TJP1(8), TJP2(3), TJP3(1), VAPA(1), YES1(1)	47822014	274	127	274	84	68	80	61	29	36	0	0.45	1.00
148	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1B(3), ACVR1C(3), ACVR2A(3), ACVRL1(3), AMHR2(4), BMP4(1), BMP5(5), BMPR1A(3), CHRD(3), COMP(1), CREBBP(12), CUL1(2), DCN(1), EP300(6), GDF5(4), GDF6(2), ID2(1), ID4(1), IFNG(1), INHBA(4), INHBC(1), LEFTY2(2), LTBP1(10), MAPK1(1), MAPK3(1), MYC(1), NODAL(3), PITX2(3), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), RBL1(5), RBL2(5), RBX1(1), ROCK1(5), ROCK2(3), RPS6KB1(1), SKP1(1), SMAD1(3), SMAD2(1), SMAD4(2), SMAD7(2), SMURF1(2), SP1(1), TGFB1(1), TGFB2(2), TGFBR2(3), THBS1(1), THBS3(3), THBS4(1), ZFYVE16(3), ZFYVE9(5)	26483908	146	94	145	39	26	48	35	17	20	0	0.45	1.00
149	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(5), CHIT1(4), CMAS(2), CTBS(4), CYB5R1(1), GFPT2(1), GNE(2), GNPDA2(3), HEXA(4), HK1(3), HK2(5), HK3(5), MTMR1(1), MTMR2(1), MTMR6(4), UAP1(1)	7756350	47	38	47	13	11	16	9	3	8	0	0.45	1.00
150	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(6), COL4A2(6), COL4A3(5), COL4A4(9), COL4A5(2), COL4A6(6), SLC23A1(1), SLC23A2(2), SLC2A3(2)	6862612	39	35	39	10	12	17	4	1	5	0	0.45	1.00
151	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACPT(1), ENPP1(7), ENPP3(3), FLAD1(1), TYR(3)	2593104	16	15	16	5	3	9	2	0	2	0	0.46	1.00
152	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(12), DAXX(2), HRAS(1), PAX3(2), RARA(1), RB1(7), SP100(1), TNFRSF1A(2), TNFRSF1B(1)	5006962	29	24	29	10	6	9	2	4	8	0	0.46	1.00
153	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(1), MTMR6(4), NFS1(2), TPK1(3)	1721082	11	11	11	1	1	4	5	0	1	0	0.47	1.00
154	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	106	ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), ARHGAP5(1), BCAR1(5), CDC42(1), CDH5(1), CLDN1(2), CLDN10(4), CLDN16(4), CLDN17(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN6(1), CLDN8(1), CLDN9(3), CTNNB1(3), CTNND1(3), CXCR4(5), CYBB(6), ESAM(4), F11R(1), GNAI1(2), GNAI3(1), GRLF1(11), ICAM1(2), ITGA4(3), ITGAL(1), ITGAM(3), ITGB1(3), ITGB2(3), ITK(2), MAPK13(2), MAPK14(1), MLLT4(1), MMP2(3), MMP9(4), MSN(3), MYL2(1), MYLPF(1), NCF2(2), NCF4(1), NOX1(2), NOX3(5), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PRKCA(4), PRKCG(8), PTK2(4), PTPN11(2), PXN(3), RAC1(1), RAP1B(1), RAPGEF4(5), RASSF5(1), RHOH(3), ROCK1(5), ROCK2(3), THY1(2), TXK(3), VASP(2), VAV1(7), VAV2(3), VAV3(1), VCAM1(4), VCL(2)	32719960	211	106	211	70	52	70	45	22	22	0	0.47	1.00
155	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP6(2), ACPT(1), ENPP1(7), ENPP3(3), FLAD1(1), MTMR1(1), MTMR2(1), MTMR6(4), TYR(3)	4031522	24	22	24	7	4	10	5	0	5	0	0.47	1.00
156	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(7), AKT1(1), GNAI1(2), GNB1(1), ITGAV(3), ITGB3(3), MAPK1(1), MAPK3(1), PDGFRA(8), PIK3R1(1), PLCB1(6), PRKCA(4), PTK2(4), RAC1(1), SMPD1(3), SMPD2(1)	6767204	47	36	47	13	15	16	9	6	1	0	0.47	1.00
157	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(1), HRAS(1), JUN(3), MAP2K1(2), MAPK1(1), MAPK3(1), MYC(1), NFKB1(2), PLCB1(6), PRKCA(4), RAF1(1), RELA(2)	4191188	27	23	26	7	9	7	3	6	2	0	0.47	1.00
158	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(1), AKT3(2), IARS(3), IL13RA1(2), IL2RG(1), IL4(2), IL4R(1), INPP5D(5), JAK1(1), JAK2(3), JAK3(7), NR0B2(1), PI3(1), PPP1R13B(4), RPS6KB1(1), SERPINA4(4), SHC1(1), SOS1(6), SOS2(5), STAT6(1), TYK2(5)	9476898	57	45	57	11	5	21	17	4	10	0	0.47	1.00
159	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(2), GSS(2), NFKB1(2), NOX1(2), RELA(2), XDH(8)	2705600	18	14	18	2	4	5	2	4	3	0	0.47	1.00
160	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	50	ALG6(2), CCKBR(1), CCR3(1), CELSR1(9), CELSR2(5), CELSR3(9), CHRM2(6), CHRM3(4), CXCR3(1), DRD4(1), EDNRA(1), EMR2(4), EMR3(3), F2R(2), GHRHR(3), GPR116(5), GPR132(1), GPR133(1), GPR143(2), GPR17(3), GPR18(1), GPR55(1), GPR56(1), GPR61(2), GPR77(3), GRM1(10), GRPR(2), HRH4(3), LGR6(2), LPHN2(6), LTB4R2(1), NTSR1(3), OR8G2(1), P2RY13(1), PTGFR(2), SMO(1), SSTR2(2), TAAR5(5), TSHR(1), VN1R1(2)	17100282	114	73	114	44	31	38	25	7	13	0	0.47	1.00
161	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(2), FOS(1), HRAS(1), IGF1(3), IRS1(3), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PIK3R1(1), PTPN11(2), RAF1(1), RASA1(5), SHC1(1), SOS1(6), SRF(2)	6085998	36	32	35	5	9	11	7	4	5	0	0.48	1.00
162	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(1), UGDH(2), UXS1(3)	1073162	7	6	7	0	0	3	2	1	1	0	0.48	1.00
163	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(2), ABP1(4), ACADL(2), ACADM(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), AOC2(1), AOC3(3), CNDP1(3), DPYD(7), DPYS(4), GAD1(4), GAD2(5), HADHA(2), MLYCD(1), SDS(2), SMS(2)	7843214	51	40	51	17	14	20	8	5	4	0	0.49	1.00
164	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(1), AOC3(3), CES1(2)	1611612	10	9	10	5	4	2	2	2	0	0	0.49	1.00
165	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(1), ACADS(2), ACAT1(1), HADHA(2)	1468678	8	8	8	1	2	2	1	1	2	0	0.49	1.00
166	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(1), IFNG(1), IL4(2), TGFB1(1), TGFB2(2), TGFBR2(3), TGFBR3(6)	2875946	16	16	16	7	0	7	6	0	3	0	0.49	1.00
167	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(2), ABP1(4), ACADM(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), AOC2(1), AOC3(3), CNDP1(3), DPYD(7), DPYS(4), GAD1(4), GAD2(5), HADHA(2), HIBCH(1), MLYCD(1), SMS(2)	7313308	47	37	47	16	15	17	6	5	4	0	0.50	1.00
168	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(2), MMP2(3), MMP9(4), RECK(3), TIMP2(1)	2030980	14	11	14	3	2	6	3	2	1	0	0.50	1.00
169	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(1), ALDOB(2), FBP2(1), GOT2(2), GPT(1), GPT2(2), MDH1(1), MDH2(1), ME3(1), PGK1(1), PGK2(4), PKLR(3), PKM2(2), RPIA(1), TKT(1), TPI1(3)	4972608	27	26	27	15	5	8	7	3	4	0	0.51	1.00
170	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(5), DARS(1), EPRS(10), FARS2(1), HARS(2), IARS(3), KARS(2), LARS2(3), MARS(1), NARS(2), RARS(4), SARS(2), TARS(3), WARS(3), WARS2(1), YARS(1)	8565716	45	42	45	12	6	15	17	2	5	0	0.51	1.00
171	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(2), CHAT(2), DBH(1), DDC(2), GAD1(4), GAD2(5), HDC(3), PAH(1), PNMT(2), TH(1), TPH1(1)	3978300	24	22	24	9	8	10	4	1	1	0	0.51	1.00
172	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	A1BG(1), AKT1(1), AKT3(2), BTK(4), GSK3A(3), IARS(3), INPP5D(5), PDK1(1), PPP1R13B(4), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(1), SOS1(6), SOS2(5), TEC(2), YWHAB(1), YWHAQ(1)	8850516	49	41	49	8	6	14	14	3	12	0	0.52	1.00
173	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD3D(1), CD80(2), CD86(1), HLA-DRA(1), HLA-DRB1(1), ICOS(2), ITK(2), LCK(2), PIK3R1(1), PTPN11(2)	2833226	15	15	15	7	2	6	3	2	2	0	0.52	1.00
174	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(1), EIF4A1(4), EIF4A2(2), EIF4B(4), EIF4G1(6), EIF4G2(2), EIF4G3(3), PDK2(1), PDPK1(1), PIK3R1(1), RPS6(1), RPS6KB1(1), TSC1(5), TSC2(5)	6686392	37	32	37	9	3	14	9	4	7	0	0.52	1.00
175	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(2), LDLR(3), LPL(3)	1424534	9	9	9	2	5	3	1	0	0	0	0.52	1.00
176	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPPL1(3), ITPKA(1), ITPKB(4), OCRL(5), PIK3C2A(4), PIK3C2B(6), PIK3C2G(6), PIK3CB(2), PIK3CG(9), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCG1(1), PLCG2(3)	11733582	76	52	76	23	24	17	17	6	12	0	0.52	1.00
177	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(11), RANGAP1(4)	2248318	15	13	15	5	2	6	3	2	2	0	0.52	1.00
178	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(2), CHKA(2), PDHA1(2), PDHA2(5)	1926672	13	12	13	2	3	6	3	1	0	0	0.52	1.00
179	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(2), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(2), GAPDH(2), GAPDHS(1), GCK(1), GOT2(2), GPI(5), HK1(3), HK2(5), HK3(5), LDHAL6B(1), LDHB(2), LDHC(1), MDH1(1), MDH2(1), PC(2), PCK1(1), PDHA1(2), PDHA2(5), PFKL(2), PFKM(4), PFKP(2), PGAM2(1), PGK1(1), PGK2(4), PKLR(3), PKM2(2), TPI1(3)	11286268	73	54	73	25	19	28	13	6	7	0	0.52	1.00
180	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), FDXR(2)	4317924	21	20	21	7	5	3	7	1	5	0	0.52	1.00
181	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(3), E2F1(2), ETS1(2), ETV3(2), FOS(1), HDAC5(1), HRAS(1), JUN(3), NCOR2(6), RBL1(5), RBL2(5), SIN3A(5), SIN3B(3)	7269342	41	36	40	9	7	15	8	7	4	0	0.53	1.00
182	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(1), BCAR1(5), ILK(1), ITGB1(3), MAPK1(1), MAPK3(1), PDK2(1), PDPK1(1), PIK3R1(1), PTK2(4), SHC1(1), SOS1(6)	4492542	26	23	26	5	8	7	7	2	2	0	0.53	1.00
183	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	41	ABCA1(5), ABCA10(8), ABCA12(7), ABCA13(25), ABCA2(6), ABCA3(3), ABCA4(10), ABCA5(4), ABCA6(6), ABCA7(3), ABCA8(5), ABCA9(9), ABCB10(4), ABCB11(5), ABCB4(6), ABCB5(6), ABCB6(3), ABCB7(2), ABCB8(1), ABCB9(3), ABCC1(4), ABCC10(5), ABCC11(3), ABCC2(4), ABCC3(1), ABCC4(1), ABCC5(4), ABCC6(1), ABCC8(5), ABCC9(9), ABCD1(3), ABCD4(1), ABCG1(1), ABCG2(1), ABCG4(1), ABCG5(1), ABCG8(4), CFTR(5), TAP1(2)	30600336	177	104	177	69	39	65	40	12	21	0	0.54	1.00
184	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MYC(1), SP1(1), SP3(1), WT1(4)	1666614	9	9	9	4	2	1	4	2	0	0	0.54	1.00
185	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(7), CPEB1(1), EGFR(6), ERBB2(1), ERBB4(9), ETS1(2), ETV6(4), KRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), NOTCH1(10), NOTCH2(6), NOTCH3(4), NOTCH4(3), PIWIL1(5), PIWIL2(3), PIWIL3(3), RAF1(1), SOS1(6), SOS2(5), SPIRE1(1)	13594750	82	61	81	25	17	32	13	6	14	0	0.54	1.00
186	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(2), CP(2), CPOX(2), EPRS(10), FECH(2), GUSB(2), PPOX(1), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2B15(1), UGT2B4(4), UROD(1)	7022990	38	35	38	9	6	14	13	2	3	0	0.55	1.00
187	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(1), GLI2(4), GLI3(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), SMO(1), SUFU(2)	4465486	25	23	25	12	4	11	4	3	3	0	0.55	1.00
188	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	CEBPA(1), CHUK(2), DAXX(2), EGF(6), EGFR(6), ETS1(2), FOS(1), HOXA7(2), HRAS(1), IKBKB(2), JUN(3), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K14(1), MAP3K5(3), MAPK1(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCQ(4), RAF1(1), RELA(2), SP1(1), TNFRSF1A(2), TNFRSF1B(1)	13433838	77	60	75	17	23	24	14	6	10	0	0.55	1.00
189	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), CD4(1), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL4(2), IL5RA(2)	1438952	9	8	9	2	1	4	1	0	3	0	0.55	1.00
190	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(2), FOS(1), HRAS(1), JAK1(1), JUN(3), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8(2), PDGFRA(8), PIK3R1(1), PLCG1(1), PRKCA(4), RAF1(1), RASA1(5), SHC1(1), SOS1(6), SRF(2), STAT1(2), STAT3(1), STAT5A(2)	8769348	49	42	48	11	16	11	11	5	6	0	0.56	1.00
191	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(5), IL4(2), MAF(1), MAP2K3(2), MAPK14(1), NFATC2(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	3260782	23	19	23	6	10	7	3	1	2	0	0.56	1.00
192	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(1), CDK7(1), CHEK1(4), NEK1(3), WEE1(2)	1979716	11	11	11	1	3	5	2	0	1	0	0.56	1.00
193	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(6), GGT1(1)	1181208	7	6	7	4	1	2	3	0	1	0	0.56	1.00
194	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	126	ALCAM(3), CADM1(2), CADM3(3), CD2(1), CD22(5), CD226(3), CD276(1), CD34(2), CD4(1), CD40(1), CD40LG(2), CD58(1), CD6(1), CD80(2), CD86(1), CD8B(1), CDH1(3), CDH2(9), CDH3(1), CDH4(6), CDH5(1), CLDN1(2), CLDN10(4), CLDN16(4), CLDN17(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN6(1), CLDN8(1), CLDN9(3), CNTN1(9), CNTN2(1), CNTNAP1(3), ESAM(4), F11R(1), GLG1(3), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-G(1), ICAM1(2), ICAM3(2), ICOS(2), ITGA4(3), ITGA6(3), ITGA8(8), ITGAL(1), ITGAM(3), ITGAV(3), ITGB1(3), ITGB2(3), ITGB7(1), ITGB8(3), L1CAM(2), MADCAM1(1), MAG(4), NCAM1(2), NCAM2(10), NEGR1(2), NEO1(3), NFASC(5), NLGN1(7), NLGN2(1), NLGN3(4), NRCAM(3), NRXN2(7), NRXN3(7), PTPRC(3), PTPRF(6), PTPRM(6), PVRL1(2), PVRL3(2), SDC1(1), SDC2(2), SDC3(1), SELE(4), SELL(2), SELP(8), SELPLG(1), SIGLEC1(7), VCAM1(4), VCAN(15)	39026856	261	117	260	98	62	104	54	19	22	0	0.57	1.00
195	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(6), GNAS(5), GNB1(1), HRAS(1), ITGB1(3), KLK2(1), MAP2K1(2), MAPK1(1), MAPK3(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(8), PTPRR(7), RAF1(1), RPS6KA1(2), RPS6KA5(4), SHC1(1), SOS1(6), STAT3(1)	9071948	54	45	53	12	16	12	19	5	2	0	0.57	1.00
196	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(5), AR(4), ESR1(5), ESR2(1), HNF4A(2), NR0B1(4), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(3), NR2F6(1), NR4A1(4), NR4A2(3), NR5A2(4), PGR(3), PPARA(1), PPARD(1), RARA(1), RARB(2), RARG(1), ROR1(3), RORA(2), RORC(2), RXRA(1), RXRG(4), THRA(1), THRB(1), VDR(3)	11522474	67	52	67	21	19	20	14	4	10	0	0.57	1.00
197	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1G(2), MEF2A(2), MEF2C(3), MEF2D(2)	1618376	9	9	9	6	3	2	1	2	1	0	0.57	1.00
198	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	AKT1(1), APC(9), CAV3(1), DAG1(1), DLG4(1), EPHB2(4), GNAI1(2), ITPR1(4), ITPR2(11), ITPR3(1), KCNJ5(2), KCNJ9(2), MAPK1(1), PITX2(3), PTX3(2), RAC1(1), RHO(1), RYR1(24)	12333620	71	55	71	20	15	26	14	6	10	0	0.58	1.00
199	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3)	4058222	19	18	19	7	4	2	7	1	5	0	0.58	1.00
200	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3)	4058222	19	18	19	7	4	2	7	1	5	0	0.58	1.00
201	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3)	4058222	19	18	19	7	4	2	7	1	5	0	0.58	1.00
202	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(4), DLG4(1), EPHB2(4), F2RL1(3), F2RL2(1), F2RL3(1), JUN(3), MAP2K5(1), MAPK1(1), MAPK7(1), MAPK8(2), MYEF2(3), PLD1(6), PLD2(2), PLD3(1), PTK2(4), RAF1(1), RASAL1(3), TEC(2), VAV1(7)	7510888	51	37	50	16	13	17	11	4	6	0	0.58	1.00
203	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(6), ATR(12), CDC25C(1), CHEK1(4), CHEK2(3)	4065520	26	21	26	1	6	7	4	5	4	0	0.58	1.00
204	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	19	ALDH18A1(3), ARG1(2), ASL(3), CKB(1), CKM(2), CKMT2(1), GATM(1), GLUD1(4), NAGS(1), ODC1(1), OTC(2), SMS(2)	3860642	23	20	23	5	5	9	5	0	4	0	0.58	1.00
205	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(1), AKT3(2), BCR(1), BTK(4), CD19(2), FLOT1(1), GAB1(2), ITPR1(4), ITPR2(11), ITPR3(1), LYN(1), NR0B2(1), PDK1(1), PHF11(1), PITX2(3), PLCG2(3), PPP1R13B(4), PREX1(12), PTPRC(3), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KB1(1), SYK(1), TEC(2), VAV1(7)	14183574	75	58	75	26	16	25	14	7	13	0	0.58	1.00
206	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	16	CXCR4(5), FOS(1), JUN(3), MAPK14(1), MAPK8(2), PLCG1(1), PRKCA(4), SYT1(3)	3539708	20	19	19	8	7	5	4	3	1	0	0.59	1.00
207	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(1), GRIA2(3), PPP1R1B(1)	1061414	5	5	5	5	0	2	1	0	2	0	0.59	1.00
208	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(2), ATF2(2), EGFR(6), HRAS(1), JUN(3), MAP2K1(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(2), MEF2C(3), MEF2D(2), PAK1(1), PRKCA(4), PTK2(4), RAC1(1), RAF1(1), SHC1(1), SOS1(6), SYT1(3)	9123746	51	46	49	18	16	13	12	6	4	0	0.59	1.00
209	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	ARSB(1), GNS(1), GUSB(2), HEXA(4), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), SPAM1(3)	4588306	23	22	23	4	3	7	7	1	5	0	0.60	1.00
210	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(2), CREBBP(12), EP300(6), FADD(1), HDAC3(1), IKBKB(2), NFKB1(2), RELA(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1)	6117860	33	28	32	9	7	9	6	4	7	0	0.60	1.00
211	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(1), HLA-DRA(1), HLA-DRB1(1)	650412	3	3	3	2	0	1	0	0	2	0	0.60	1.00
212	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(2), FBP2(1), GOT2(2), GPT(1), GPT2(2), MDH1(1), MDH2(1), ME2(2), ME3(1), PGK1(1), PKLR(3), PKM2(2), RPIA(1), TKT(1), TPI1(3)	4743700	25	24	25	13	5	7	6	3	4	0	0.60	1.00
213	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(1), APC(9), CD14(1), CTNNB1(3), DVL1(3), FZD1(1), GJA1(4), GNAI1(2), IRAK1(3), LBP(4), LEF1(3), NFKB1(2), PDPK1(1), PIK3R1(1), RELA(2), TOLLIP(1)	7187818	41	34	41	8	9	10	11	5	6	0	0.60	1.00
214	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(2), EGF(6), EGFR(6), FOS(1), HRAS(1), JAK1(1), JUN(3), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8(2), PIK3R1(1), PLCG1(1), PRKCA(4), RAF1(1), RASA1(5), SHC1(1), SOS1(6), SRF(2), STAT1(2), STAT3(1), STAT5A(2)	9513210	53	44	51	10	16	14	11	4	8	0	0.61	1.00
215	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(5), GOT2(2), LDHAL6B(1), LDHB(2), LDHC(1), SDS(2), SULT1B1(4), SULT1C2(3), SULT1C4(1)	3393748	21	18	21	4	2	9	6	2	2	0	0.61	1.00
216	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	60	AKT1(1), AKT3(2), BCL2L1(1), CDC42(1), CREB1(1), CREB3(2), CREB5(3), ERBB4(9), F2RL2(1), GAB1(2), GADD45A(1), GSK3A(3), IGF1(3), INPPL1(3), IRS1(3), IRS2(2), IRS4(2), MET(3), MYC(1), NOLC1(2), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PARD3(5), PARD6A(1), PDK1(1), PIK3CD(3), PPP1R13B(4), PREX1(12), PTK2(4), PTPN1(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(1), SLC2A4(2), SOS1(6), SOS2(5), TSC1(5), TSC2(5), YWHAB(1), YWHAQ(1)	20089970	119	76	119	33	22	41	29	9	18	0	0.61	1.00
217	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	7	IFNAR1(2), IFNB1(1), JAK1(1), PTPRU(5), STAT1(2), STAT2(1), TYK2(5)	3290686	17	17	17	5	2	9	1	3	2	0	0.61	1.00
218	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	9	GPR37(2), SNCAIP(3), UBE2E2(1), UBE2G2(1), UBE2L6(1)	1465118	8	8	8	3	1	0	5	0	2	0	0.62	1.00
219	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(2), ADSL(1), ADSS(1), AGXT2(1), ASL(3), ASNS(3), CAD(8), DARS(1), DDO(2), GAD1(4), GAD2(5), GOT2(2), GPT(1), GPT2(2), NARS(2), PC(2)	7056632	41	34	41	16	7	20	8	3	3	0	0.62	1.00
220	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL4(2), ST3GAL5(2), ST8SIA1(2)	1506770	8	8	8	6	2	2	3	0	1	0	0.62	1.00
221	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(9), APC2(2), CAMK2B(2), CAMK2D(1), CCND2(3), CCND3(1), CHD8(8), CHP(2), CREBBP(12), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(2), CTBP1(1), CTNNB1(3), CUL1(2), DAAM1(1), DAAM2(5), DKK1(3), DKK2(1), DVL1(3), DVL3(2), EP300(6), FZD1(1), FZD10(1), FZD3(4), FZD4(1), FZD6(2), FZD7(1), FZD9(2), JUN(3), LEF1(3), LRP5(6), LRP6(3), MAP3K7(2), MAPK10(1), MAPK8(2), MAPK9(1), MYC(1), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NKD1(1), NKD2(2), NLK(2), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PORCN(2), PPARD(1), PPP2R1A(5), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRICKLE1(5), PRICKLE2(1), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), PSEN1(1), RAC1(1), RBX1(1), ROCK1(5), ROCK2(3), RUVBL1(2), SENP2(3), SFRP1(1), SFRP4(3), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(1), SMAD4(2), TBL1XR1(2), TBL1Y(2), TCF7(1), VANGL1(1), VANGL2(1), WIF1(3), WNT10B(2), WNT11(1), WNT2(3), WNT2B(2), WNT3(2), WNT3A(1), WNT6(2), WNT7A(2), WNT7B(1), WNT9A(1), WNT9B(1)	44342292	243	120	241	79	67	81	41	26	28	0	0.62	1.00
222	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), CACNA1C(12), CACNA1D(3), CACNA1F(8), CACNA1S(5), CALML6(1), CAMK2B(2), CAMK2D(1), CDC42(1), EGFR(6), FSHB(1), GNAS(5), HBEGF(1), HRAS(1), ITPR1(4), ITPR2(11), ITPR3(1), JUN(3), KRAS(1), LHB(1), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K4(4), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(2), MAPK9(1), MMP14(2), MMP2(3), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLD1(6), PLD2(2), PRKACB(2), PRKACG(1), PRKCA(4), PRKCD(2), PRKX(1), RAF1(1), SOS1(6), SOS2(5)	34541612	194	107	192	57	53	67	38	18	18	0	0.63	1.00
223	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(2), ACAD9(3), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(4), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(3), HADHB(2), LIPA(2), RDH11(1), RDH12(2), RDH13(1), SLC27A5(4), SOAT2(1), SRD5A1(2), SRD5A2(2)	8668778	50	42	50	12	12	19	6	7	6	0	0.63	1.00
224	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(1), AKT3(2), BCR(1), BLNK(1), BTK(4), CD19(2), CD22(5), CD81(1), CR2(9), DAG1(1), FLOT1(1), GSK3A(3), INPP5D(5), ITPR1(4), ITPR2(11), ITPR3(1), LYN(1), MAP4K1(2), MAPK1(1), MAPK3(1), NFATC2(4), NR0B2(1), PDK1(1), PIK3CD(3), PIK3R1(1), PLCG2(3), PPP1R13B(4), PPP3CA(2), PPP3CB(4), PPP3CC(2), PTPRC(3), RAF1(1), SHC1(1), SOS1(6), SOS2(5), SYK(1), VAV1(7)	19587120	106	72	106	34	26	30	19	12	19	0	0.63	1.00
225	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(9), ATF2(2), BMP10(1), BMP4(1), BMP5(5), BMPR1A(3), CHRD(3), CTNNB1(3), DVL1(3), FZD1(1), MAP3K7(2), MEF2C(3), MYL2(1), NKX2-5(2), RFC1(1), TGFB1(1), TGFB2(2), TGFBR2(3), TGFBR3(6)	9785906	52	44	52	14	10	15	14	6	7	0	0.63	1.00
226	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CUL1(2), E2F1(2), RB1(7), SKP2(1)	2358678	12	11	12	1	1	6	0	0	5	0	0.63	1.00
227	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(3), PRKCA(4)	1368286	7	7	7	1	2	1	3	0	1	0	0.63	1.00
228	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12A(1), IL12B(2), IL4(2), LTA(2), TGFB1(1), TGFB2(2)	3596846	19	18	19	6	2	6	5	3	3	0	0.64	1.00
229	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	30	ABP1(4), ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), ALDH3B2(1), AOC2(1), AOC3(3), AOX1(9), DBH(1), DCT(1), DDC(2), FAH(1), GOT2(2), GSTZ1(2), HPD(1), PNMT(2), TAT(1), TH(1), TYR(3)	7878636	42	38	42	14	12	17	4	7	2	0	0.64	1.00
230	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(5), CXCR4(5), GNAI1(2), GNB1(1), HRAS(1), MAP2K1(2), MAPK1(1), MAPK3(1), NFKB1(2), PIK3C2G(6), PIK3R1(1), PLCG1(1), PRKCA(4), PTK2(4), PXN(3), RAF1(1), RELA(2)	7100954	42	34	42	14	12	15	7	5	3	0	0.64	1.00
231	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), PLCB1(6), PRKCA(4), RELA(2)	2235858	14	11	14	4	5	4	1	2	2	0	0.64	1.00
232	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), ACO2(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SUCLA2(2)	2378792	12	12	12	3	2	6	1	2	1	0	0.64	1.00
233	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(3), GRHPR(1), HAO1(5), MDH1(1), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3)	3428992	20	18	20	2	6	6	5	2	1	0	0.65	1.00
234	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(2), TAT(1)	702744	3	3	3	2	1	1	0	1	0	0	0.65	1.00
235	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	30	ALOX15(2), CYP1A2(1), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2J2(1), CYP3A4(1), CYP3A43(3), CYP3A7(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), RDH11(1), RDH12(2), RDH13(1)	6365636	39	32	39	13	13	9	8	4	5	0	0.65	1.00
236	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(1), B4GALT1(1), B4GALT3(1), B4GALT4(1), CHST1(2), CHST2(3), CHST4(2), CHST6(3), FUT8(2), ST3GAL1(1), ST3GAL4(2)	3427212	20	18	20	10	8	6	4	2	0	0	0.65	1.00
237	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(1), GGPS1(2), IDI1(1), IDI2(2), SQLE(2)	1174622	8	7	8	0	3	2	1	2	0	0	0.65	1.00
238	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(1), ACACB(8), AKT1(1), AKT3(2), ARAF(3), BRAF(7), CALML6(1), CBL(1), CBLB(4), EXOC7(1), FBP2(1), FLOT1(1), G6PC(2), G6PC2(1), GCK(1), GYS1(1), GYS2(4), HRAS(1), IKBKB(2), INPP5D(5), INSR(7), IRS1(3), IRS2(2), IRS4(2), KRAS(1), LIPE(1), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MKNK2(1), PCK1(1), PCK2(1), PDE3A(4), PDE3B(3), PDPK1(1), PFKL(2), PFKM(4), PFKP(2), PHKA1(4), PHKA2(2), PHKB(6), PHKG1(2), PHKG2(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PKLR(3), PKM2(2), PPARGC1A(5), PPP1R3C(2), PPP1R3D(2), PRKAA2(3), PRKACB(2), PRKACG(1), PRKAG2(4), PRKAG3(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCI(4), PRKX(1), PTPN1(1), PTPRF(6), PYGB(3), PYGM(4), RAF1(1), RAPGEF1(3), RPS6(1), RPS6KB1(1), SHC1(1), SHC2(2), SHC3(2), SHC4(4), SLC2A4(2), SOCS2(1), SORBS1(5), SOS1(6), SOS2(5), SREBF1(2), TRIP10(2), TSC1(5), TSC2(5)	42874504	226	114	226	79	53	78	49	16	30	0	0.66	1.00
239	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(5), CRY1(1), CRY2(2), PER1(4)	2337496	14	12	14	3	0	5	7	1	1	0	0.66	1.00
240	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(2), FOS(1), HRAS(1), JAK2(3), JUN(3), MAP2K1(2), MAPK3(1), MPL(2), PIK3R1(1), PLCG1(1), PRKCA(4), RAF1(1), RASA1(5), SHC1(1), SOS1(6), STAT1(2), STAT3(1), STAT5A(2)	7485434	39	34	38	6	10	7	10	4	8	0	0.66	1.00
241	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(3), MBTPS1(3), MBTPS2(3), SCAP(4), SREBF1(2), SREBF2(2)	3331092	18	17	18	3	5	5	4	4	0	0	0.66	1.00
242	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2A(1), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2E3(1), UBE2G2(1), UBE2J1(2), UBE2L6(1), UBE2M(1), UBE3A(5)	2847644	15	15	15	4	4	6	2	1	2	0	0.66	1.00
243	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), DLAT(1), DLD(2), DLST(1), FH(2), IDH3A(1), IDH3B(3), IDH3G(1), MDH1(1), MDH2(1), OGDH(3), PC(2), PDHA1(2), PDHA2(5), PDK1(1), PDK2(1), PDK3(2), PDK4(2), PDP2(4), SDHA(1), SUCLA2(2), SUCLG2(1)	7678564	42	37	42	12	5	17	7	8	5	0	0.66	1.00
244	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(1), CREB1(1), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(2), PIK3R1(1), RB1(7), RELA(2), SP1(1)	4701692	26	22	26	6	7	9	2	2	6	0	0.67	1.00
245	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(2), ANAPC1(4), ANAPC4(3), ANAPC5(4), ATM(6), ATR(12), BUB1(3), BUB1B(6), BUB3(2), CCNB1(1), CCNB3(9), CCND2(3), CCND3(1), CCNE2(2), CDC25B(1), CDC25C(1), CDC27(2), CDC6(4), CDC7(1), CDK7(1), CDKN2C(1), CHEK1(4), CHEK2(3), CREBBP(12), CUL1(2), DBF4(4), E2F1(2), EP300(6), ESPL1(2), GADD45A(1), GADD45G(1), HDAC1(2), MAD1L1(5), MAD2L1(2), MCM2(1), MCM3(1), MCM4(3), MCM5(6), MCM6(1), MCM7(3), MDM2(1), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), PKMYT1(1), PLK1(1), PRKDC(11), PTTG1(1), PTTG2(2), RB1(7), RBL1(5), RBL2(5), RBX1(1), SFN(2), SKP1(1), SKP2(1), SMAD2(1), SMAD4(2), SMC1A(2), SMC1B(4), TGFB1(1), TGFB2(2), WEE1(2), YWHAB(1), YWHAQ(1)	36875548	189	108	188	45	45	65	37	18	24	0	0.67	1.00
246	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(4), ATP4A(6), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5G2(2), ATP5G3(1), ATP5L(1), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), COX4I1(1), COX4I2(1), COX6B1(1), COX7B2(2), CYC1(4), NDUFA13(2), NDUFA7(1), NDUFAB1(1), NDUFB5(2), NDUFB8(1), NDUFS1(3), NDUFS6(1), NDUFS8(1), NDUFV1(2), NDUFV2(2), SDHA(1), UQCRB(1), UQCRC2(1)	15113624	74	59	74	21	12	24	22	7	9	0	0.68	1.00
247	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(5), GCLC(2), GCLM(1), GGT1(1), GPX5(1), GPX6(2), GSR(2), GSS(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(3), GSTM5(2), GSTZ1(2), IDH1(2), MGST1(1), OPLAH(3)	6086710	33	30	33	10	7	15	7	3	1	0	0.68	1.00
248	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	303668	1	1	1	0	0	1	0	0	0	0	0.68	1.00
249	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	29	AKR1C3(1), ALOX15(2), CYP4F2(3), CYP4F3(2), EPX(4), GGT1(1), LPO(2), LTA4H(2), MPO(3), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PRDX1(1), PRDX6(1), PTGS1(2), TBXAS1(2)	7056988	41	35	41	23	8	13	15	2	3	0	0.68	1.00
250	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(1), DOCK1(3), FOS(1), GAB1(2), HGF(6), HRAS(1), ITGA1(3), ITGB1(3), JUN(3), MAP2K1(2), MAP4K1(2), MAPK1(1), MAPK3(1), MAPK8(2), MET(3), PAK1(1), PIK3R1(1), PTK2(4), PTPN11(2), PXN(3), RAF1(1), RAP1B(1), RASA1(5), SOS1(6), STAT3(1)	11291786	59	49	58	23	14	19	10	7	9	0	0.69	1.00
251	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(1), EIF4A1(4), EIF4A2(2), EIF4G1(6), EIF4G2(2), EIF4G3(3), GHR(2), IRS1(3), MAPK1(1), MAPK14(1), MAPK3(1), PABPC1(2), PDK2(1), PDPK1(1), PIK3R1(1), PRKCA(4), RPS6KB1(1)	6769340	36	33	36	12	5	15	9	4	3	0	0.69	1.00
252	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(5), CKM(2), FBL(1), GPT(1), LDHB(2), LDHC(1), MAPK14(1), NCL(1)	2415104	14	12	14	4	2	7	2	1	2	0	0.70	1.00
253	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	ACTA1(1), AGT(1), AKT1(1), CALR(1), CAMK1G(2), CAMK4(3), CREBBP(12), CSNK1A1(2), ELSPBP1(1), FGF2(2), HAND1(1), HAND2(1), HRAS(1), IGF1(3), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MEF2C(3), NFATC2(4), NFATC3(2), NFATC4(1), NKX2-5(2), PIK3R1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RAF1(1), RPS6KB1(1), SYT1(3)	11982604	73	51	73	25	19	22	10	13	9	0	0.70	1.00
254	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CD3D(1), FOS(1), FYN(3), HRAS(1), JUN(3), LCK(2), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB1(2), PIK3R1(1), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKCA(4), RAC1(1), RAF1(1), RASA1(5), RELA(2), SHC1(1), SOS1(6), SYT1(3), VAV1(7), ZAP70(2)	12376696	69	52	68	11	19	16	12	13	9	0	0.70	1.00
255	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), GCK(1), GNE(2), GNPDA2(3), HEXA(4), HK1(3), HK2(5), HK3(5), UAP1(1)	4584390	26	22	26	7	7	9	3	3	4	0	0.70	1.00
256	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CD44(3), CSF1(2), FCGR3A(3), IL1B(1), IL6R(1), SELL(2), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(1)	3779118	22	18	22	8	6	6	5	2	3	0	0.70	1.00
257	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(3), C5(1), C7(7), C8A(3), C9(1)	2928990	15	14	15	7	3	4	5	2	1	0	0.71	1.00
258	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	8	IFNG(1), IFNGR1(3), JAK1(1), JAK2(3), PLA2G2A(1), PTPRU(5), STAT1(2)	3011048	16	15	16	3	2	7	5	0	2	0	0.71	1.00
259	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), EGR1(2), HRAS(1), KLK2(1), MAP2K1(2), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1)	2270034	11	11	11	3	2	6	2	1	0	0	0.71	1.00
260	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	89	ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), AKAP1(2), AKAP11(7), AKAP12(3), AKAP3(6), AKAP5(1), AKAP6(11), AKAP7(2), AKAP8(3), AKAP9(7), ARHGEF1(2), CHMP1B(1), GNA12(1), GNA14(1), GNAI3(1), GNAL(1), GNAZ(2), GNB1(1), GNB2(2), GNB5(1), GNG12(1), GNG4(2), GNG5(1), HRAS(1), ITPR1(4), KRAS(1), PDE1A(2), PDE1B(1), PDE4A(1), PDE4B(3), PDE4C(2), PDE4D(1), PDE7B(1), PDE8A(5), PDE8B(2), PLCB3(3), PPP3CA(2), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCI(4), PRKCQ(4), PRKD1(9), PRKD3(2), SLC9A1(3), USP5(1)	30555480	173	95	173	42	48	53	35	17	20	0	0.71	1.00
261	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	84	ABL1(2), ABL2(5), AKT1(1), AKT3(2), ARAF(3), AREG(2), BRAF(7), CAMK2B(2), CAMK2D(1), CBL(1), CBLB(4), EGF(6), EGFR(6), ERBB2(1), ERBB3(3), ERBB4(9), EREG(1), GAB1(2), HBEGF(1), HRAS(1), JUN(3), KRAS(1), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MYC(1), NCK1(2), NRG1(3), NRG2(2), NRG3(5), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PRKCA(4), PRKCG(8), PTK2(4), RAF1(1), RPS6KB1(1), SHC1(1), SHC2(2), SHC3(2), SHC4(4), SOS1(6), SOS2(5), STAT5A(2), TGFA(1)	27584304	159	93	157	54	40	54	31	12	22	0	0.71	1.00
262	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	73	ACP1(1), ACTB(1), ACTN1(2), ACTN2(6), ACTN3(2), ACTN4(4), ACVR1B(3), ACVR1C(3), CDC42(1), CDH1(3), CREBBP(12), CSNK2A1(2), CTNNB1(3), CTNND1(3), EGFR(6), EP300(6), ERBB2(1), FARP2(6), FER(2), FGFR1(1), FYN(3), INSR(7), IQGAP1(6), LEF1(3), LMO7(6), MAP3K7(2), MAPK1(1), MAPK3(1), MET(3), MLLT4(1), NLK(2), PARD3(5), PTPN1(1), PTPRB(13), PTPRF(6), PTPRJ(2), PTPRM(6), PVRL1(2), PVRL3(2), PVRL4(5), RAC1(1), SMAD2(1), SMAD4(2), SNAI1(3), SNAI2(2), SORBS1(5), SSX2IP(1), TCF7(1), TGFBR2(3), TJP1(8), VCL(2), WAS(4), WASF3(1), WASL(2), YES1(1)	31278694	182	99	180	50	31	58	50	19	24	0	0.71	1.00
263	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(3), GRHPR(1), HAO1(5), MDH1(1), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3)	3592396	20	18	20	2	6	6	5	2	1	0	0.72	1.00
264	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(1), GTF2B(1), GTF2E1(1), GTF2F1(1), HDAC3(1), NCOA1(5), NCOA2(9), NCOA3(4), NCOR2(6), POLR2A(1), RARA(1), RXRA(1), TBP(1)	6895008	34	30	34	13	8	12	5	2	7	0	0.72	1.00
265	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GHR(2), HRAS(1), INSR(7), IRS1(3), JAK2(3), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3R1(1), PLCG1(1), PRKCA(4), RAF1(1), RPS6KA1(2), SHC1(1), SLC2A4(2), SOS1(6), SRF(2), STAT5A(2)	8349802	42	38	42	9	8	14	12	4	4	0	0.72	1.00
266	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ARPC1A(2), CDC42(1), PAK1(1), PDGFRA(8), PIK3R1(1), RAC1(1), WASL(2)	2999656	16	15	16	3	5	4	4	3	0	0	0.72	1.00
267	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(2), FLT3(4), IGF1(3), TGFB1(1), TGFB2(2)	2290504	12	12	12	9	2	6	4	0	0	0	0.72	1.00
268	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	AKT1(1), APC(9), AR(4), BRAF(7), CCL16(1), DAG1(1), EGFR(6), GNAI1(2), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), KCNJ5(2), KCNJ9(2), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(2), PIK3CD(3), PIK3R1(1), PITX2(3), PTX3(2), RAF1(1)	13775954	71	57	70	18	21	20	16	5	9	0	0.72	1.00
269	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), HLA-DRA(1), HLA-DRB1(1)	817376	3	3	3	0	0	1	0	0	2	0	0.72	1.00
270	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(7), CREB1(1), FOS(1), GNAI1(2), GNAS(5), GNB1(1), HRAS(1), JUN(3), MAP2K1(2), MAPK3(1), NFATC2(4), NFATC3(2), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), RAF1(1), RPS6KA3(1), SYT1(3)	9434534	57	43	56	14	18	17	7	10	5	0	0.73	1.00
271	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(2), GAPDH(2), GCK(1), GPI(5), HK1(3), HK2(5), HK3(5), LDHB(2), LDHC(1), PDHA1(2), PDHA2(5), PFKM(4), PFKP(2), PGK1(1), PKLR(3), PKM2(2), TPI1(3)	12973530	74	59	74	19	20	31	14	6	3	0	0.73	1.00
272	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(2), GAPDH(2), GCK(1), GPI(5), HK1(3), HK2(5), HK3(5), LDHB(2), LDHC(1), PDHA1(2), PDHA2(5), PFKM(4), PFKP(2), PGK1(1), PKLR(3), PKM2(2), TPI1(3)	12973530	74	59	74	19	20	31	14	6	3	0	0.73	1.00
273	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(12), EP300(6), IKBKB(2), IL1B(1), MAP2K3(2), MAP2K6(2), MAP3K14(1), MAP3K7(2), MAPK14(1), NFKB1(2), RELA(2), TGFBR2(3), TLR2(3)	8069630	41	36	40	11	10	12	8	3	8	0	0.73	1.00
274	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(1), CPT1A(3), LEPR(10), PRKAA2(3), PRKAG2(4)	3886986	21	20	21	6	8	5	6	1	1	0	0.74	1.00
275	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS2(1), PON1(4), PON2(1), PON3(1), RDH11(1), RDH12(2), RDH13(1)	2268076	11	11	11	3	3	3	1	2	2	0	0.74	1.00
276	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT9(1), GBGT1(2), GLA(2), HEXA(4), ST3GAL1(1), ST3GAL4(2), ST8SIA1(2)	2748498	14	12	14	5	2	5	4	2	1	0	0.74	1.00
277	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), AZIN1(1), BTG1(1), CLOCK(5), CRY1(1), CRY2(2), EIF4G2(2), ETV6(4), GSTM3(1), HERPUD1(1), HSPA8(3), IDI1(1), KLF9(1), MYF6(1), NCKAP1(4), PER1(4), PER2(2), PIGF(1), PPP1R3C(2), PSMA4(1), PURA(1), SF3A3(2), UCP3(3), UGP2(4), VAPA(1), ZFR(4)	9949310	55	43	55	13	7	18	17	4	9	0	0.74	1.00
278	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(3), JAK3(7), MAPK1(1), MAPK3(1), STAT3(1), TYK2(5)	3262918	19	16	19	3	2	10	5	1	1	0	0.74	1.00
279	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS2(1), SULT1A2(2), SULT1E1(1), SULT2A1(3)	1626208	8	8	8	3	2	3	2	0	1	0	0.74	1.00
280	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(4), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(3), HADHB(2), SOAT2(1), SRD5A1(2), SRD5A2(2)	6312592	35	30	35	8	7	15	6	4	3	0	0.74	1.00
281	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2R(2), F2RL3(1), GNAI1(2), GNB1(1), HRAS(1), ITGA1(3), ITGB1(3), MAP2K1(2), MAPK1(1), MAPK3(1), PLA2G4A(5), PLCB1(6), PRKCA(4), PTGS1(2), PTK2(4), RAF1(1), SYK(1), TBXAS1(2)	6603266	42	32	42	12	13	15	7	3	4	0	0.75	1.00
282	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	52	ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), AGPAT3(1), AGPAT6(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), CEL(1), DAK(1), DGAT2(2), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKI(7), DGKZ(3), GK(4), GK2(5), GLA(2), GPAM(2), LIPA(2), LIPC(1), LIPF(1), LIPG(2), LPL(3), MGLL(1), PNLIPRP1(3), PNLIPRP2(2), PNPLA3(1), PPAP2B(1)	14585320	76	61	76	30	20	35	7	9	5	0	0.75	1.00
283	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(4), FOS(1), HRAS(1), JUN(3), LYN(1), MAP2K1(2), MAP3K1(2), MAPK14(1), MAPK3(1), MAPK8(2), NFATC2(4), NFATC3(2), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKCA(4), RAC1(1), RAF1(1), SHC1(1), SOS1(6), SYK(1), SYT1(3), VAV1(7)	10354616	59	46	58	12	18	12	12	10	7	0	0.75	1.00
284	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(1), AKT3(2), HRAS(1), MAP2K1(2), NGFR(1), NTRK1(3), PIK3CD(3), SHC1(1), SOS1(6)	3889122	20	18	20	8	4	8	4	2	2	0	0.75	1.00
285	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(2), FOS(1), HRAS(1), JUN(3), KLK2(1), MAP2K1(2), MAPK3(1), MAPK8(2), NGFR(1), PIK3R1(1), PLCG1(1), RAF1(1), SHC1(1), SOS1(6)	4595960	24	22	23	6	7	6	7	3	1	0	0.75	1.00
286	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	244	ACVR1B(3), ACVR2A(3), AMHR2(4), BMPR1A(3), CCL14(2), CCL16(1), CCL20(1), CCL26(2), CCL3(2), CCR1(2), CCR3(1), CCR4(3), CCR6(2), CCR8(1), CD27(1), CD40(1), CD40LG(2), CNTFR(1), CSF1(2), CSF1R(3), CSF2RB(5), CSF3R(5), CX3CR1(3), CXCL5(2), CXCR3(1), CXCR4(5), EDA2R(1), EGF(6), EGFR(6), EPOR(2), FAS(1), FASLG(1), FLT1(8), FLT3(4), FLT4(3), GDF5(4), GH2(2), GHR(2), HGF(6), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), IL10(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL17A(1), IL17RA(3), IL18R1(2), IL18RAP(2), IL1B(1), IL1R2(3), IL1RAP(2), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL22RA2(1), IL23R(1), IL28B(1), IL2RB(2), IL2RG(1), IL4(2), IL4R(1), IL5RA(2), IL6R(1), IL7R(2), INHBA(4), INHBC(1), KIT(5), LEPR(10), LIFR(2), LTA(2), LTBR(1), MET(3), MPL(2), NGFR(1), OSMR(2), PDGFB(1), PDGFC(1), PDGFRA(8), PDGFRB(4), PF4(1), PLEKHO2(3), PRL(1), PRLR(5), TGFB1(1), TGFB2(2), TGFBR2(3), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(1), TNFRSF11B(1), TNFRSF13B(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF6B(1), TNFRSF9(1), TNFSF11(1), TNFSF13(1), TNFSF14(1), TNFSF18(1), VEGFC(4), XCL1(1), XCR1(1)	46077970	260	120	258	107	69	91	54	16	30	0	0.75	1.00
287	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGA4(3), ITGAL(1), ITGAM(3), ITGB1(3), ITGB2(3), SELE(4), SELL(2), SELP(8)	4718780	32	23	32	7	8	9	9	2	4	0	0.75	1.00
288	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(3), C5(1), C7(7), ICAM1(2), ITGA4(3), ITGAL(1), ITGB1(3), ITGB2(3), SELP(8), SELPLG(1), VCAM1(4)	6211488	36	29	36	10	8	9	10	5	4	0	0.76	1.00
289	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT2(2), COASY(2), DPYD(7), DPYS(4), ENPP1(7), ENPP3(3), ILVBL(2), PANK3(1), PPCS(1), VNN1(2)	4731952	31	23	31	9	10	9	7	2	3	0	0.76	1.00
290	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), CBS(4), MUT(1)	1333932	7	6	7	0	0	5	0	0	2	0	0.76	1.00
291	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	CDK5(1), CFL1(2), CHN1(2), MAP3K1(2), MYL2(1), MYLK(5), NCF2(2), PAK1(1), PDGFRA(8), PIK3R1(1), PLD1(6), PPP1R12B(4), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(5), VAV1(7)	8864578	50	39	50	17	9	18	14	7	2	0	0.76	1.00
292	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2)	1501074	7	7	7	2	3	4	0	0	0	0	0.76	1.00
293	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(2), FUT3(3), ST3GAL4(2)	1955330	9	9	9	4	3	0	5	1	0	0	0.76	1.00
294	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(2), FOS(1), JUN(3), MAPK3(1), POLR2A(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2)	3384492	17	16	16	5	5	6	1	2	3	0	0.76	1.00
295	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(19), B3GALT4(1), CDR1(2), DGKI(7), MRPL19(1), PIGK(1), RPL14(1), RPL19(1), RPL32(1), RPL37(1), RPL3L(1), RPL4(1), RPL5(1), RPL7(1), RPL8(2), RPLP0(2), RPS11(1), RPS18(1), RPS2(1), RPS21(1), RPS26(1), RPS6(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA6(4), RPS6KB1(1), RPS8(1), SLC36A2(2), TBC1D10C(1), TSPAN9(1), UBB(1), UBC(1)	14395750	67	58	67	31	15	15	24	11	2	0	0.76	1.00
296	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	15	B3GALT4(1), HEXA(4), SLC33A1(2), ST3GAL1(1), ST3GAL5(2), ST6GALNAC3(3), ST6GALNAC5(2), ST8SIA1(2)	3398732	17	16	17	8	6	4	4	0	3	0	0.76	1.00
297	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1), CFL1(2), CFLAR(1)	1038452	4	4	4	1	0	3	0	0	1	0	0.76	1.00
298	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNB1(1), CCND2(3), CCND3(1), CDK7(1), CDKN2C(1), E2F1(2), RB1(7), RBL1(5)	4212192	21	18	21	3	2	6	4	3	6	0	0.76	1.00
299	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), FH(2), MDH1(1), OGDH(3), SDHA(1), SUCLA2(2)	2517098	12	12	12	6	1	5	2	3	1	0	0.76	1.00
300	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	8	HK1(3), KHK(1), MPI(1), PYGM(4), TPI1(3), TREH(1)	2572278	13	12	13	4	3	2	6	0	2	0	0.76	1.00
301	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(2), CAPNS2(1), CDK5(1), CSNK1A1(2), MAPT(4)	2580466	11	11	11	1	1	5	0	1	4	0	0.77	1.00
302	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(1), AKT3(2), CARD11(3), CBL(1), CBLB(4), CD3D(1), CD4(1), CD40LG(2), CD8B(1), CDC42(1), CHP(2), CHUK(2), FOS(1), FYN(3), HRAS(1), ICOS(2), IFNG(1), IKBKB(2), IL10(1), IL4(2), ITK(2), JUN(3), KRAS(1), LCK(2), LCP2(2), MALT1(1), MAP3K14(1), NCK1(2), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB1(2), NFKB2(2), NFKBIB(1), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PDK1(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKCQ(4), PTPRC(3), RASGRP1(1), SOS1(6), SOS2(5), TEC(2), VAV1(7), VAV2(3), VAV3(1), ZAP70(2)	27075046	139	88	138	44	31	40	28	20	20	0	0.77	1.00
303	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	9	B2M(1), CD3D(1), GZMB(1), ICAM1(2), ITGAL(1), ITGB2(3), PRF1(1)	2139916	10	10	10	6	1	4	2	2	1	0	0.77	1.00
304	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT3(2), APC(9), CSNK1A1(2), CTNNB1(3), DACT1(3), DKK1(3), DKK2(1), DVL1(3), FSTL1(2), GSK3A(3), LRP1(10), MVP(2), NKD1(1), NKD2(2), PSEN1(1), SENP2(3), SFRP1(1), WIF1(3)	10938100	55	46	55	15	15	16	13	2	9	0	0.77	1.00
305	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGF(6), EGFR(6), TF(5), TFRC(2)	3479188	20	17	19	2	8	8	2	0	2	0	0.78	1.00
306	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(2), IKBKAP(2), IKBKB(2), LTA(2), MAP3K1(2), MAP3K14(1), NFKB1(2), RELA(2), TANK(4), TNFAIP3(3), TNFRSF1B(1), TRAF1(4), TRAF3(1)	6090804	28	24	28	10	5	4	6	5	8	0	0.78	1.00
307	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(5), CARS(5), DARS(1), DARS2(5), EARS2(2), EPRS(10), FARS2(1), FARSA(2), HARS(2), HARS2(2), IARS(3), IARS2(3), KARS(2), LARS2(3), MARS(1), NARS(2), NARS2(2), PARS2(2), RARS(4), RARS2(2), SARS(2), SARS2(2), TARS(3), TARS2(2), VARS(3), VARS2(1), WARS(3), WARS2(1), YARS(1)	14615580	78	58	78	23	9	30	24	5	10	0	0.78	1.00
308	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), HMGCL(1), OXCT1(2)	901926	4	4	4	3	3	1	0	0	0	0	0.78	1.00
309	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(2), FBP2(1), GPI(5), H6PD(2), PFKM(4), PFKP(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RBKS(1), RPIA(1), TAL1(2), TALDO1(1), TKT(1)	5552176	26	25	26	12	6	8	4	3	5	0	0.78	1.00
310	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(2), C1QB(2), C1R(2), C1S(2), C2(1), C3(3), C5(1), C7(7), C8A(3), C9(1)	4329494	24	20	24	11	5	9	6	2	2	0	0.78	1.00
311	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(3), IFNGR2(1), JAK1(1), JAK2(3), STAT1(2)	2203818	11	10	11	2	2	3	5	0	1	0	0.78	1.00
312	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(1), CREB1(1), HRAS(1), MAPK1(1), MAPK3(1), MAPK7(1), MEF2A(2), MEF2C(3), MEF2D(2), NTRK1(3), PIK3R1(1), PLCG1(1), RPS6KA1(2), SHC1(1)	4600410	21	20	21	8	6	7	3	3	2	0	0.79	1.00
313	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(3), HK2(5), HK3(5), IMPA1(1), TGDS(1)	2756330	16	14	16	4	6	6	1	2	1	0	0.79	1.00
314	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(2), E2F1(2), MDM2(1), MYC(1), PIK3R1(1), POLR1A(2), POLR1B(2), POLR1D(1), RAC1(1), RB1(7), TBX2(3)	4540424	23	19	23	7	5	7	0	4	7	0	0.79	1.00
315	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(1), ITGAM(3), ITGB2(3), SELE(4), SELL(2)	3233726	18	16	18	5	5	5	5	2	1	0	0.79	1.00
316	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(6), EGFR(6), MAP2K1(2), MAP3K1(2), MAPK14(1), NCOR2(6), RARA(1), RXRA(1), THRA(1), THRB(1)	4792828	27	23	26	9	12	8	4	0	3	0	0.79	1.00
317	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(2), RDH11(1), RDH12(2), RDH13(1)	1309724	6	6	6	2	3	0	0	2	1	0	0.79	1.00
318	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	78	AIFM1(1), AKT1(1), AKT3(2), APAF1(1), ATM(6), BAX(1), BCL2L1(1), BIRC3(3), CAPN1(2), CAPN2(2), CASP10(3), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHP(2), CHUK(2), CSF2RB(5), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKB(2), IL1B(1), IL1RAP(2), IRAK1(3), IRAK3(3), MAP3K14(1), NFKB1(2), NFKB2(2), NTRK1(3), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(2), TNFRSF10A(1), TNFRSF10B(1), TNFRSF1A(2), TRADD(1)	21763526	111	74	111	39	32	34	10	17	18	0	0.79	1.00
319	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(5), FOS(1), HRAS(1), JAK2(3), MAP2K1(2), MAPK3(1), RAF1(1), SHC1(1), SOS1(6), STAT5A(2)	4575846	23	22	23	2	6	7	6	1	3	0	0.79	1.00
320	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(1), ITGB1(3), KLRC1(1), KLRC3(1), MAP2K1(2), MAPK3(1), PAK1(1), PIK3R1(1), RAC1(1), SYK(1), VAV1(7)	4237290	20	19	20	6	6	4	5	4	1	0	0.80	1.00
321	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(2), DPYD(7), DPYS(4), ENPP1(7), ENPP3(3), PANK3(1), PPCS(1)	3808488	25	18	25	8	7	9	4	2	3	0	0.80	1.00
322	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(6), CCND2(3), DAZL(1), DMC1(1), EGR1(2), ESR2(1), INHA(3), LHCGR(7), MLH1(1), MSH5(2), NCOR1(5), NRIP1(3), PGR(3), PRLR(5), PTGER2(2), SMPD1(3), VDR(3), ZP2(2)	9107726	53	40	53	21	18	16	5	6	8	0	0.80	1.00
323	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(1), IDI1(1), SQLE(2)	887152	4	4	4	0	2	1	0	1	0	0	0.80	1.00
324	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(1), ATM(6), ATR(12), BAI1(8), BAX(1), CASP8(1), CASP9(2), CCNB1(1), CCNB3(9), CCND2(3), CCND3(1), CCNE2(2), CCNG1(1), CD82(1), CHEK1(4), CHEK2(3), DDB2(3), EI24(1), FAS(1), GADD45A(1), GADD45G(1), GTSE1(2), IGF1(3), IGFBP3(1), LRDD(1), MDM2(1), PPM1D(1), RFWD2(4), RRM2B(2), SERPINB5(2), SESN1(3), SESN2(2), SESN3(2), SFN(2), SIAH1(1), STEAP3(2), THBS1(1), TNFRSF10B(1), TSC2(5)	17264754	99	66	99	17	19	36	19	12	13	0	0.80	1.00
325	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	8	ADAR(4), APOBEC2(1), APOBEC3F(1), APOBEC4(3)	1832866	9	8	9	3	4	0	2	1	2	0	0.80	1.00
326	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(1), IL4R(1), JAK1(1), JAK2(3), TYK2(5)	2816850	13	12	13	5	1	4	5	1	2	0	0.80	1.00
327	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(1), IL4R(1), JAK1(1), JAK2(3), TYK2(5)	2816850	13	12	13	5	1	4	5	1	2	0	0.80	1.00
328	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), FURIN(1), NOTCH1(10), PSEN1(1)	2659320	13	11	13	6	2	6	0	1	4	0	0.80	1.00
329	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB4A(3)	1158068	5	5	5	9	3	2	0	0	0	0	0.81	1.00
330	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ABP1(4), ALDH3B2(1), AOC2(1), AOC3(3), DDC(2), EPX(4), GOT2(2), HPD(1), LPO(2), MPO(3), PRDX1(1), PRDX6(1), TAT(1)	5494504	26	25	26	16	8	6	9	3	0	0	0.81	1.00
331	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(1), B4GALT4(1), FUT3(3), FUT5(4), FUT6(2), FUT9(1), GCNT2(1), ST8SIA1(2)	4446796	22	19	22	12	7	6	6	2	1	0	0.81	1.00
332	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(3), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(2), G6PC2(1), GAPDH(2), GAPDHS(1), GCK(1), GPI(5), HK1(3), HK2(5), HK3(5), LDHAL6B(1), LDHB(2), LDHC(1), PDHA1(2), PDHA2(5), PFKL(2), PFKM(4), PFKP(2), PGAM2(1), PGK1(1), PGK2(4), PKLR(3), PKM2(2), TPI1(3)	15403764	87	64	87	27	25	33	15	8	6	0	0.81	1.00
333	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(1), BCL2L1(1), CASP9(2), CDC42(1), CHUK(2), H2AFX(1), HRAS(1), MAP2K1(2), MAPK3(1), NFKB1(2), PIK3R1(1), RAC1(1), RAF1(1), RALA(2), RALBP1(1), RALGDS(1), RELA(2)	4640638	23	20	23	6	6	5	3	6	3	0	0.81	1.00
334	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(4), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH9A1(2), AOC2(1), AOC3(3), CNDP1(3), DDC(2), HARS(2), HDC(3), HNMT(2), PRPS1(1), PRPS2(1)	6575498	31	30	31	14	10	11	6	3	1	0	0.81	1.00
335	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	9	ADH5(1), EPX(4), LPO(2), MPO(3), MTHFR(1), PRDX6(1)	2704176	12	12	12	8	1	4	6	1	0	0	0.82	1.00
336	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT3(2), ARHGEF11(7), CDC42(1), DLG4(1), LPA(11), MAP3K1(2), MAP3K5(3), MAPK8(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PDK1(1), PHKA2(2), PI3(1), PIK3CB(2), PLD1(6), PLD2(2), PLD3(1), PTK2(4), RDX(1), ROCK1(5), ROCK2(3), SERPINA4(4), SRF(2), TBXA2R(2)	13379548	76	54	75	27	11	31	18	9	7	0	0.82	1.00
337	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(7), ARHGEF1(2), F2R(2), F2RL3(1), GNA12(1), GNAI1(2), GNB1(1), MAP3K7(2), PIK3R1(1), PLCB1(6), PPP1R12B(4), PRKCA(4), ROCK1(5)	6447694	38	30	38	11	9	16	7	4	2	0	0.82	1.00
338	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(1), AKT3(2), BPNT1(1), ILK(1), MAPK1(1), MAPK3(1), PDK1(1), PIK3CD(3), RBL2(5), SHC1(1), SOS1(6)	4702582	23	21	23	5	4	7	7	3	2	0	0.82	1.00
339	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	12	ADH5(1), EPX(4), LPO(2), MPO(3), PRDX1(1), PRDX6(1)	2761848	12	12	12	9	1	3	7	1	0	0	0.82	1.00
340	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(9), CERK(3), CREB1(1), CREB3(2), CREB5(3), DAG1(1), EPHB2(4), FOS(1), ITPKA(1), ITPKB(4), JUN(3), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1)	7865998	42	34	41	11	12	12	10	2	6	0	0.82	1.00
341	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(4), AOC2(1), AOC3(3), CES1(2), CES7(1), DDHD1(4), ESCO1(1), LIPA(2), MYST3(9), MYST4(3), PLA1A(5), PNPLA3(1), PRDX6(1), SH3GLB1(1)	6849084	39	31	39	17	11	14	7	4	3	0	0.82	1.00
342	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	14	NDUFB5(2), NDUFS1(3), NDUFV1(2), NDUFV2(2)	1823966	9	8	9	2	4	2	2	1	0	0	0.82	1.00
343	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA3(6), GGT1(1)	1569604	7	6	7	4	1	2	3	0	1	0	0.82	1.00
344	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	71	B2M(1), CALR(1), CANX(1), CD4(1), CD8B(1), CIITA(3), CREB1(1), CTSL1(1), CTSS(2), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-G(1), HSP90AB1(2), HSPA5(3), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), KIR2DL1(1), KIR2DL3(4), KIR3DL1(6), KIR3DL2(1), KIR3DL3(1), KLRC1(1), KLRC3(1), LTA(2), NFYB(1), PSME2(1), TAP1(2), TAPBP(3)	12369754	64	46	63	29	8	19	19	7	11	0	0.82	1.00
345	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(3), LPL(3), RXRA(1)	1557322	7	7	7	3	2	4	0	1	0	0	0.83	1.00
346	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(7), ASH2L(2), CARM1(1), CTCFL(2), DOT1L(4), EED(2), EHMT2(1), EZH1(3), EZH2(4), FBXO11(4), HSF4(1), JMJD6(1), KDM6A(3), MEN1(2), MLL(4), MLL3(20), MLL4(5), MLL5(3), NSD1(8), OGT(2), PRDM2(4), PRDM9(9), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), RBBP5(1), SATB1(2), SETD1A(6), SETD2(4), SETD8(1), SETDB1(3), SMYD3(1), STK38(4), SUV39H1(1), SUV39H2(2), SUV420H1(1), SUZ12(3), WHSC1(1), WHSC1L1(12)	30009554	142	92	142	38	24	44	32	11	29	2	0.83	1.00
347	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(1), EGFR(6), MYC(1), POLR2A(1), PRKCA(4), RB1(7), TEP1(3), TERF1(2), TERT(3), TNKS(7), XRCC5(1)	7453394	36	30	35	7	7	12	5	3	9	0	0.83	1.00
348	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	52	ABP1(4), ACAT1(1), ACMSD(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), AOC2(1), AOC3(3), AOX1(9), CYP19A1(4), CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2B6(3), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(2), CYP4F8(1), DDC(2), GCDH(1), HADHA(2), KMO(2), KYNU(3), SDS(2), TDO2(1), TPH1(1), WARS(3), WARS2(1)	14418534	80	60	80	39	23	26	20	7	4	0	0.83	1.00
349	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(3), LARS2(3), PDHA1(2), PDHA2(5)	2688156	13	12	13	2	1	6	4	1	1	0	0.83	1.00
350	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(1), AKT3(2), BCR(1), BLNK(1), BTK(4), CD19(2), DAG1(1), EPHB2(4), ITPKA(1), ITPKB(4), LYN(1), MAP2K1(2), MAPK1(1), NFAT5(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PI3(1), PIK3CD(3), PIK3R1(1), PLCG2(3), PPP1R13B(4), RAF1(1), SERPINA4(4), SHC1(1), SOS1(6), SOS2(5), SYK(1), VAV1(7)	13747830	74	53	74	21	16	21	16	9	12	0	0.83	1.00
351	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(6), CDC25B(1), CDC25C(1), CHEK1(4), RB1(7), WEE1(2)	4531524	21	18	21	1	4	8	1	1	7	0	0.83	1.00
352	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CD3D(1), CD4(1)	675510	2	2	2	2	0	1	0	0	1	0	0.83	1.00
353	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(1), AKT3(2), CASP9(2), CDC42(1), CHP(2), HRAS(1), KRAS(1), MAP2K1(2), MAPK1(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPKAPK2(1), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NOS3(1), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLCG1(1), PLCG2(3), PPP3CA(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(3), PRKCA(4), PRKCG(8), PTK2(4), PXN(3), RAC1(1), RAF1(1), SHC2(2), SPHK2(1)	18488860	106	67	106	36	32	30	16	17	11	0	0.83	1.00
354	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(9), CCND2(3), CCND3(1), CTNNB1(3), DVL1(3), DVL3(2), FZD1(1), FZD10(1), FZD3(4), FZD6(2), FZD7(1), FZD9(2), JUN(3), LDLR(3), MAPK10(1), MAPK9(1), MYC(1), PAFAH1B1(1), PLAU(2), PPP2R5C(5), PRKCA(4), PRKCD(2), PRKCE(3), PRKCG(8), PRKCI(4), PRKCQ(4), PRKD1(9), RAC1(1), SFRP4(3), TCF7(1), WNT10B(2), WNT11(1), WNT2(3), WNT2B(2), WNT3(2), WNT6(2), WNT7A(2), WNT7B(1)	16330076	103	64	102	26	32	32	22	10	7	0	0.83	1.00
355	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(2), UGDH(2), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2B15(1), UGT2B4(4)	4394820	20	19	20	4	4	6	8	1	1	0	0.83	1.00
356	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNB1(1), JAK1(1), STAT1(2), STAT2(1), TYK2(5)	2905494	13	13	13	5	3	5	1	3	1	0	0.84	1.00
357	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(5), GCLC(2), GCLM(1), GGT1(1), GPX5(1), GSS(2), GSTA2(1), GSTA4(1), GSTM3(1), GSTM4(3), GSTM5(2), GSTZ1(2), IDH1(2), MGST1(1)	4947866	25	23	25	8	7	12	4	2	0	0	0.84	1.00
358	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(4), FCER1A(2), FOS(1), HRAS(1), JUN(3), LYN(1), MAP2K1(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(2), NFATC2(4), NFATC3(2), NFATC4(1), PIK3R1(1), PLA2G4A(5), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), RAF1(1), SHC1(1), SOS1(6), SYK(1), SYT1(3), VAV1(7)	11048638	61	47	60	19	17	14	12	11	7	0	0.84	1.00
359	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(1), GALNT10(1), GALNT2(2), GALNT3(2), GALNT6(2), GALNT8(2), GCNT1(2), ST3GAL1(1), ST3GAL4(2)	3526536	15	14	14	5	3	4	6	1	1	0	0.85	1.00
360	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	CREBBP(12), EP300(6), FYN(3), IL2RG(1), IL7R(2), JAK1(1), JAK3(7), LCK(2), NMI(1), PIK3R1(1), STAT5A(2)	7041502	38	31	37	13	6	15	9	4	4	0	0.85	1.00
361	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT3(1), AGPAT6(1), ENPP2(6), ENPP6(1), PAFAH1B1(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLD1(6), PLD2(2), PPAP2B(1)	6222702	35	28	35	18	6	16	8	1	4	0	0.85	1.00
362	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(2), ATP6V0D1(1), ATP6V0D2(2), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), CDC42(1), CHUK(2), EGFR(6), F11R(1), GIT1(1), HBEGF(1), IGSF5(2), IKBKB(2), JUN(3), LYN(1), MAP3K14(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK8(2), MAPK9(1), MET(3), NFKB1(2), NFKB2(2), NOD1(4), PAK1(1), PLCG1(1), PLCG2(3), PTPN11(2), PTPRZ1(8), RAC1(1), RELA(2), TJP1(8)	19090856	95	65	93	19	27	22	19	10	17	0	0.85	1.00
363	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(3), HLA-DRA(1), HLA-DRB1(1), LCK(2), PTPRC(3), ZAP70(2)	2464054	14	11	14	6	2	7	2	1	2	0	0.85	1.00
364	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	29	ADCY3(4), ADRBK2(1), CALML6(1), CAMK2B(2), CAMK2D(1), CLCA1(4), CLCA2(4), CLCA4(2), CNGA3(3), CNGA4(4), CNGB1(4), GNAL(1), GUCA1A(2), PRKACB(2), PRKACG(1), PRKG1(4), PRKG2(3), PRKX(1)	7900530	44	34	44	11	16	10	5	5	8	0	0.86	1.00
365	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO1(1), ACO2(3), ACSS1(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SUCLA2(2)	3552346	15	15	15	5	3	6	2	3	1	0	0.86	1.00
366	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(2), FOS(1), HRAS(1), IL2RB(2), IL2RG(1), JAK1(1), JAK3(7), JUN(3), LCK(2), MAP2K1(2), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(6), STAT5A(2), SYK(1)	6428648	36	29	35	9	9	13	9	2	3	0	0.86	1.00
367	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(2), ATM(6), BUB1(3), BUB1B(6), BUB3(2), CCNB1(1), CCNB3(9), CCND2(3), CCND3(1), CCNE2(2), CDAN1(3), CDC25B(1), CDC25C(1), CDC6(4), CDC7(1), CDH1(3), CHEK1(4), CHEK2(3), DTX4(1), E2F1(2), EP300(6), ESPL1(2), GADD45A(1), HDAC1(2), HDAC3(1), HDAC4(4), HDAC5(1), MAD1L1(5), MAD2L1(2), MCM2(1), MCM3(1), MCM4(3), MCM5(6), MCM6(1), MCM7(3), MDM2(1), MPEG1(4), MPL(2), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), PLK1(1), PRKDC(11), PTTG1(1), PTTG2(2), RB1(7), RBL1(5), SKP2(1), SMAD4(2), TBC1D8(1), TGFB1(1), WEE1(2)	29837428	142	92	141	37	30	51	29	11	21	0	0.87	1.00
368	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(5), ALG1(1), ALG13(6), ALG2(2), ALG6(2), B3GALT6(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT1(1), B4GALT3(1), B4GALT4(1), B4GALT5(2), C1GALT1C1(1), CHPF(1), CHST1(2), CHST12(1), CHST2(3), CHST3(2), CHST4(2), CHST6(3), DDOST(1), EXT1(2), EXT2(1), EXTL1(1), EXTL3(1), FUT8(2), GALNT1(1), GALNT10(1), GALNT11(2), GALNT12(3), GALNT14(3), GALNT2(2), GALNT3(2), GALNT5(6), GALNT6(2), GALNT8(2), GALNTL1(3), GALNTL4(3), GALNTL5(3), GANAB(5), GCNT1(2), GCNT3(2), HS3ST2(1), HS3ST5(4), HS6ST1(2), HS6ST3(2), MAN1A1(3), MAN1A2(3), MAN1C1(3), MAN2A1(3), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(4), NDST1(2), NDST2(1), NDST3(4), OGT(2), RPN1(1), ST3GAL1(1), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(3), STT3B(1), XYLT1(2)	29176692	148	95	147	54	34	57	28	17	12	0	0.87	1.00
369	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	30	ACP1(1), ACPT(1), ALPL(3), ALPP(2), ALPPL2(1), CYP19A1(4), CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2B6(3), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(2), CYP4F8(1), PON1(4)	7658806	47	34	47	26	16	12	14	3	2	0	0.87	1.00
370	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(6), ATR(12), BRCA1(6), CCNB1(1), CDC25B(1), CDC25C(1), CHEK1(4), CHEK2(3), EP300(6), GADD45A(1), MDM2(1), PRKDC(11), RPS6KA1(2), WEE1(2), YWHAQ(1)	11367080	58	46	57	7	12	18	12	9	7	0	0.87	1.00
371	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(1), ITGB2(3), PTPRC(3), THY1(2)	3034544	14	14	14	9	2	8	1	2	1	0	0.87	1.00
372	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(1), ALDOB(2), DERA(1), FBP2(1), GPI(5), H6PD(2), PFKL(2), PFKM(4), PFKP(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RBKS(1), RPIA(1), TALDO1(1), TKT(1)	6312058	27	27	27	12	7	8	5	2	5	0	0.87	1.00
373	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(2), CD3D(1), CD4(1), CD58(1)	1701146	6	6	6	6	1	3	0	0	2	0	0.87	1.00
374	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGA4(3), ITGAL(1), ITGB1(3), ITGB2(3), SELE(4), SELL(2)	3655764	21	16	21	3	5	6	7	2	1	0	0.88	1.00
375	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(1), AKR1C4(1), ALDH3B2(1), CYP1A2(1), CYP2B6(3), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2F1(3), CYP2S1(1), CYP3A4(1), CYP3A43(3), CYP3A7(1), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(3), GSTM5(2), GSTZ1(2), MGST1(1), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2)	14629286	82	59	82	33	24	22	25	7	4	0	0.88	1.00
376	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(2), ACADS(2), ACAT1(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH5A1(1), ALDH9A1(2), GAD1(4), GAD2(5), HADHA(2), HMGCL(1), OXCT1(2), PDHA1(2), PDHA2(5), SDS(2)	6966742	38	31	38	16	8	18	4	4	4	0	0.88	1.00
377	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(4), ACY3(2), ALDH1B1(2), ALDH2(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), AMDHD1(1), AOC2(1), AOC3(3), CARM1(1), CNDP1(3), DDC(2), HARS(2), HARS2(2), HDC(3), HNMT(2), LCMT1(2), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), PRPS1(1), PRPS2(1), UROC1(1), WBSCR22(3)	10716134	52	45	52	17	22	15	8	4	3	0	0.88	1.00
378	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(1), AASS(6), ACAT1(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(4), EHMT2(1), GCDH(1), HADH(1), HADHA(2), HSD17B4(1), NSD1(8), OGDH(3), OGDHL(4), PIPOX(1), PLOD1(4), PLOD2(4), PLOD3(5), RDH11(1), RDH12(2), RDH13(1), SETD1A(6), SETDB1(3), SPCS1(1), SPCS3(2), SUV39H1(1), SUV39H2(2)	15838974	77	58	77	33	9	24	22	8	14	0	0.88	1.00
379	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(2), FUCA1(1), HEXA(4), MAN2C1(5), MANBA(2), NEU1(2), NEU2(2)	3513542	18	14	18	4	4	5	7	0	2	0	0.89	1.00
380	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FOS(1), FYN(3), JUN(3), MAPK14(1), THBS1(1)	1984344	10	9	9	1	2	2	4	2	0	0	0.89	1.00
381	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), ICAM1(2), ITGAL(1), ITGB2(3), PTPRC(3), THY1(2)	2883956	13	13	13	8	2	8	1	2	0	0	0.89	1.00
382	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(1), CHUK(2), CRADD(1), IKBKB(2), JUN(3), LTA(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K14(1), MAP4K2(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(2), TANK(4), TNFRSF1A(2), TRADD(1)	6698318	33	27	32	10	8	9	6	3	7	0	0.89	1.00
383	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	FUT9(1), GBGT1(2), GLA(2), HEXA(4), ST3GAL1(1), ST8SIA1(2)	2913504	12	11	12	5	2	5	2	2	1	0	0.89	1.00
384	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(9), CTNNB1(3), DLL1(1), DVL1(3), FZD1(1), NOTCH1(10), PSEN1(1)	5808318	28	24	28	8	6	10	5	1	6	0	0.89	1.00
385	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(1), PSMC3(1), PSMD14(3), RPN1(1), UBE2A(1), UBE3A(5)	3479544	15	15	15	3	4	6	3	0	2	0	0.89	1.00
386	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(1), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), ELAVL1(1), FLT1(8), FLT4(3), HIF1A(1), HRAS(1), NOS3(1), PIK3R1(1), PLCG1(1), PRKCA(4), PTK2(4), PXN(3), SHC1(1), VHL(1)	7939156	35	32	35	15	9	10	6	7	3	0	0.89	1.00
387	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ABP1(4), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), ALDH3B2(1), AOC2(1), AOC3(3), AOX1(9), CARM1(1), DBH(1), DCT(1), DDC(2), ECH1(1), ESCO1(1), FAH(1), GOT2(2), GSTZ1(2), HPD(1), LCMT1(2), MYST3(9), MYST4(3), PNMT(2), PNPLA3(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), SH3GLB1(1), TAT(1), TH(1), TYR(3), TYRP1(2), WBSCR22(3)	15374572	77	59	77	23	21	29	9	10	8	0	0.89	1.00
388	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(1), ATM(6), BAX(1), E2F1(2), GADD45A(1), MDM2(1), RB1(7)	4723408	19	18	19	1	3	7	1	2	6	0	0.89	1.00
389	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(1), ARHGDIB(1), BAG4(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), CRADD(1), DAXX(2), DFFB(2), FADD(1), GSN(2), MAP3K1(2), MAP3K14(1), MAP3K5(3), MAPK8(2), MDM2(1), NFKB1(2), NUMA1(4), PRKCD(2), PRKDC(11), PSEN1(1), PSEN2(2), PTK2(4), RASA1(5), RB1(7), RELA(2), SPTAN1(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4)	19149418	82	63	82	26	16	24	11	8	23	0	0.90	1.00
390	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), BDH1(3), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(2)	1973842	9	8	9	5	3	4	1	1	0	0	0.90	1.00
391	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACADL(2), ACADM(1), ACOX1(2), ACOX3(4), ACSL1(2), ACSL3(1), ACSL6(1), ADIPOQ(1), ANGPTL4(1), APOA2(1), APOA5(3), CD36(1), CPT1A(3), CPT1C(3), CPT2(1), CYP27A1(1), CYP4A22(2), CYP7A1(3), DBI(1), FABP5(1), FABP6(1), FABP7(1), FADS2(1), GK(4), GK2(5), HMGCS2(1), ILK(1), LPL(3), MMP1(3), NR1H3(2), PCK1(1), PCK2(1), PDPK1(1), PLTP(2), PPARA(1), PPARD(1), RXRA(1), RXRG(4), SCD(1), SCP2(1), SLC27A1(1), SLC27A2(2), SLC27A4(1), SLC27A5(4), SLC27A6(3), SORBS1(5), UBC(1), UCP1(2)	17498112	90	65	90	39	24	25	27	6	8	0	0.90	1.00
392	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(7), MAP2(8), PRKACB(2), PRKACG(1), PRKAR2B(2), PRKCE(3)	4900162	23	20	23	7	6	3	9	3	2	0	0.90	1.00
393	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	34	ARSD(1), ARSE(2), B4GALT6(1), CERK(3), ENPP7(4), GAL3ST1(1), GALC(1), GLA(2), NEU1(2), NEU2(2), PPAP2B(1), SGMS1(2), SGMS2(1), SGPP1(2), SMPD1(3), SMPD2(1), SMPD3(3), SPHK2(1), SPTLC2(3), UGT8(5)	8350870	41	33	41	13	11	10	10	5	5	0	0.90	1.00
394	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), ACO2(3), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(1), IDH3B(3), IDH3G(1), MDH1(1), MDH2(1), PC(2), PCK1(1), SDHA(1), SUCLA2(2), SUCLG2(1)	5541852	25	23	25	8	5	8	3	5	4	0	0.90	1.00
395	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(4), ABCC2(4), ABCG2(1), CES1(2), CES2(1), CYP3A4(1), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1)	5763106	24	24	24	7	5	10	6	2	1	0	0.90	1.00
396	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	28	AGA(2), ARSB(1), FUCA1(1), GNS(1), GUSB(2), HEXA(4), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), MAN2B1(1), MAN2B2(3), MAN2C1(5), MANBA(2), NEU1(2), NEU2(2), SPAM1(3)	8481878	41	32	41	10	6	13	14	2	6	0	0.90	1.00
397	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(5), HRAS(1), JUN(3), MAP2K1(2), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), PAK1(1), PLCG1(1), PRKCA(4), RAC1(1), RAF1(1), SHC1(1), SOS1(6), SYT1(3)	7794620	38	34	37	11	14	8	9	5	2	0	0.90	1.00
398	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOA(1), ALDOB(2), FBP2(1), FPGT(2), GCK(1), GMPPA(1), HK1(3), HK2(5), HK3(5), KHK(1), MPI(1), PFKFB1(2), PFKM(4), PFKP(2), PMM1(1), TPI1(3)	6506434	35	28	35	13	12	8	10	3	2	0	0.90	1.00
399	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), AADAC(1), ABAT(2), ACADS(2), ACAT1(1), ACSM1(5), ALDH1B1(2), ALDH2(2), ALDH5A1(1), ALDH7A1(1), ALDH9A1(2), BDH1(3), DDHD1(4), GAD1(4), GAD2(5), HADH(1), HADHA(2), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(2), OXCT1(2), PDHA1(2), PDHA2(5), PLA1A(5), PRDX6(1), RDH11(1), RDH12(2), RDH13(1)	11071778	64	45	64	23	16	24	8	10	6	0	0.90	1.00
400	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	AKT1(1), ATM(6), BAX(1), CPB2(2), CSNK1A1(2), FHL2(1), GADD45A(1), HIF1A(1), IGFBP3(1), MAPK8(2), MDM2(1), NFKBIB(1)	4744590	20	19	20	2	4	8	3	3	2	0	0.90	1.00
401	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), CBS(4), DNMT1(3), DNMT3A(6), DNMT3B(3), MARS(1), MAT1A(1), MTR(4)	4733020	23	19	23	10	3	11	6	1	2	0	0.90	1.00
402	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	33	AKT1(1), CDC42(1), CFL1(2), CFL2(1), FLNA(8), FLNC(11), FSCN3(1), GDI1(1), GDI2(1), MYLK(5), MYLK2(2), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PFN2(1), RHO(1), ROCK1(5), ROCK2(3), VASP(2), WASL(2)	11843586	55	47	55	28	11	23	12	2	7	0	0.90	1.00
403	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2)	3593286	15	15	15	3	5	8	0	2	0	0	0.90	1.00
404	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADH(1), HADHA(2), HADHB(2), HSD17B4(1), PPT1(1)	2306524	8	8	8	2	1	0	2	3	2	0	0.91	1.00
405	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BAX(1), BCL2A1(1), BCL2L1(1), CASP1(1), CASP10(3), CASP2(1), CASP4(3), CASP7(2), CASP8(1), CASP9(2), CD40(1), CD40LG(2), CRADD(1), DAXX(2), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKE(3), LTA(2), MCL1(2), NFKB1(2), NGFR(1), NTRK1(3), PTPN13(3), SFRS2IP(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4), TRAF3(1), TRAF6(1)	12079436	57	43	57	23	12	19	7	7	12	0	0.91	1.00
406	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST12(1), PAPSS2(1), SULT1A1(1), SULT1A2(2), SULT1E1(1), SULT2A1(3)	2544332	10	10	10	5	2	3	2	2	1	0	0.91	1.00
407	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	HADHA(2), SDS(2)	1318802	4	4	4	5	0	1	1	0	2	0	0.91	1.00
408	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(1), HRAS(1), IRS1(3), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3R1(1), RAF1(1), SHC1(1), SOS1(6)	4499306	18	18	18	2	4	6	5	2	1	0	0.91	1.00
409	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(3), CASP8(1), FADD(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	2346218	10	8	10	4	3	2	0	2	3	0	0.91	1.00
410	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(1), FARS2(1), GOT2(2), PAH(1), TAT(1), YARS(1)	2211650	8	8	8	3	4	1	1	1	1	0	0.91	1.00
411	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(1), HTR2C(2), PLCB1(6)	1924358	9	8	9	4	3	4	0	2	0	0	0.91	1.00
412	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(3), CAMK2B(2), CAMK2D(1), CDK5(1), FYN(3), GNAI1(2), GNB1(1), HRAS(1), JAK2(3), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPT(4), MYLK(5), PLCG1(1), PRKCA(4), RAF1(1), SHC1(1), SOS1(6), STAT1(2), STAT3(1), STAT5A(2), SYT1(3)	11315994	55	47	55	13	12	18	14	5	6	0	0.91	1.00
413	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(1), PRKCA(4)	1819516	6	6	6	3	2	2	1	0	1	0	0.91	1.00
414	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	8	JAK1(1), JAK2(3), JAK3(7), PIAS1(2), PIAS3(2), PTPRU(5)	3736754	20	16	20	3	1	11	5	1	2	0	0.91	1.00
415	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), HRAS(1), SHC1(1), SOS1(6)	2388582	9	9	9	1	2	1	4	1	1	0	0.91	1.00
416	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(3), HK2(5), HK3(5), IMPA1(1), TGDS(1)	3175520	16	14	16	4	6	6	1	2	1	0	0.91	1.00
417	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT1(1), HADHA(2), HADHB(2), SDS(2)	2252946	8	8	8	7	1	1	2	2	2	0	0.91	1.00
418	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	ACOX1(2), APOA2(1), CD36(1), CREBBP(12), EP300(6), HSD17B4(1), JUN(3), LPL(3), MAPK1(1), MAPK3(1), MYC(1), NCOA1(5), NCOR1(5), NCOR2(6), NR0B2(1), NR1H3(2), NRIP1(3), PIK3R1(1), PPARA(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(4), RB1(7), RELA(2), RXRA(1), SP1(1), STAT5A(2)	16377780	81	59	79	34	17	27	13	9	15	0	0.91	1.00
419	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(2), BCMO1(1)	1037384	3	3	3	3	0	1	1	0	1	0	0.91	1.00
420	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(1), ARHGDIB(1), CASP1(1), CASP10(3), CASP8(1), CASP9(2), GZMB(1), JUN(3), PRF1(1)	3454802	15	15	14	8	3	5	3	2	2	0	0.91	1.00
421	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT1(1), B4GALT3(1), B4GALT5(2), FUT8(2), ST3GAL1(1), ST3GAL4(2)	2168218	9	9	9	10	2	4	2	1	0	0	0.91	1.00
422	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(1), CASP9(2), DFFB(2), GZMB(1), PRF1(1), SCAP(4), SREBF1(2), SREBF2(2)	5027432	24	21	24	10	5	9	5	3	2	0	0.92	1.00
423	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT1(1), AKT3(2), CASP8(1), CCL3(2), CD14(1), CD40(1), CD80(2), CD86(1), CHUK(2), FADD(1), FOS(1), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IKBKB(2), IKBKE(3), IL12A(1), IL12B(2), IL1B(1), IRAK1(3), IRF3(1), JUN(3), LBP(4), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K7(2), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), RAC1(1), RELA(2), STAT1(2), TBK1(2), TLR1(2), TLR2(3), TLR3(2), TLR5(2), TLR7(3), TLR8(1), TLR9(1), TOLLIP(1), TRAF3(1), TRAF6(1)	23394718	117	76	115	35	29	35	24	15	14	0	0.92	1.00
424	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(2), AP2M1(1), ARF1(1), BTK(4), EEA1(1), GSK3A(3), LYN(1), PDPK1(1), PFKL(2), PFKM(4), PFKP(2), PLCG1(1), PRKCE(3), RAC1(1), RPS6KB1(1), VAV2(3)	6962292	32	27	32	13	8	4	10	3	7	0	0.92	1.00
425	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(1), AKT3(2), BRAF(7), DAG1(1), DRD2(2), EGFR(6), EPHB2(4), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), KCNJ5(2), KCNJ9(2), MAPK1(1), PI3(1), PIK3CB(2), PITX2(3), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), RAF1(1), RGS20(1), SHC1(1), SOS1(6), SOS2(5), STAT3(1)	15750330	88	60	87	21	23	28	19	5	13	0	0.92	1.00
426	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(1), AKT3(2), GSK3A(3), IL4R(1), IRS1(3), IRS2(2), JAK1(1), JAK3(7), MAP4K1(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CD(3), PIK3R1(1), PPP1R13B(4), RAF1(1), SHC1(1), SOS1(6), SOS2(5), STAT6(1)	9492028	47	37	47	15	8	17	11	4	7	0	0.92	1.00
427	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	5	ABCB11(5), ABCB4(6), ABCC1(4), ABCC3(1)	3186912	16	14	16	7	8	4	3	1	0	0	0.92	1.00
428	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), LCMT1(2), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), WBSCR22(3)	3831272	17	16	17	2	7	5	2	1	2	0	0.92	1.00
429	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), UGDH(2)	2317560	9	9	9	1	2	6	0	1	0	0	0.92	1.00
430	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(1), GNS(1), GUSB(2), HEXA(4), IDS(1), IDUA(2)	2919378	11	10	11	0	1	3	3	1	3	0	0.92	1.00
431	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOA(1), ALDOB(2), FBP2(1), FPGT(2), FUK(1), GMPPA(1), HK1(3), HK2(5), HK3(5), KHK(1), MPI(1), MTMR1(1), MTMR2(1), MTMR6(4), PFKFB1(2), PFKL(2), PFKM(4), PFKP(2), PGM2(4), PMM1(1), RDH11(1), RDH12(2), RDH13(1), TPI1(3)	10174124	51	42	51	15	16	10	13	6	6	0	0.92	1.00
432	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(1), CAPN2(2), CAPNS2(1), EP300(6), HDAC1(2), MEF2D(2), NFATC2(4), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKCA(4), SYT1(3)	6598994	33	26	32	8	10	7	6	6	4	0	0.93	1.00
433	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALML6(1), CDS1(2), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKI(7), DGKZ(3), IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(5), INPP5D(5), INPP5E(2), INPPL1(3), ITPK1(1), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), OCRL(5), PI4KA(4), PI4KB(1), PIK3C2A(4), PIK3C2B(6), PIK3C2G(6), PIK3C3(3), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCD3(1), PLCE1(11), PLCG1(1), PLCG2(3), PLCZ1(4), PRKCA(4), PRKCG(8), SYNJ1(2), SYNJ2(3)	33604442	198	97	197	55	60	55	38	16	29	0	0.93	1.00
434	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACSL1(2), ACSL3(1), CPT1A(3), CPT2(1), DCI(1), HADHA(2), PECR(1), SCP2(1)	4528320	18	18	18	7	4	5	5	1	3	0	0.93	1.00
435	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(1), E2F1(2), HRAS(1), MAPK1(1), MAPK3(1), NFKB1(2), PAK1(1), PIK3R1(1), RAC1(1), RAF1(1), RB1(7), RELA(2)	4943950	21	18	21	2	3	7	1	4	6	0	0.93	1.00
436	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(2), FUCA1(1), HEXA(4), MAN2B1(1), MAN2B2(3), MAN2C1(5), MANBA(2), NEU1(2), NEU2(2)	4558580	22	17	22	6	4	7	8	1	2	0	0.93	1.00
437	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(1), CHRNB1(1), CHRNG(4), MUSK(2), PIK3R1(1), PTK2(4), RAPSN(3), TERT(3)	3938606	19	17	19	9	9	7	1	1	1	0	0.93	1.00
438	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2)	2153800	8	8	8	0	1	5	1	1	0	0	0.93	1.00
439	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2)	2153800	8	8	8	0	1	5	1	1	0	0	0.93	1.00
440	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(1), CFL1(2), E2F1(2), MDM2(1), PRB1(2)	1870246	8	7	8	4	1	5	1	1	0	0	0.93	1.00
441	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(2), ACTN2(6), ACTN3(2), BCAR1(5), CTNNB1(3), PTK2(4), PXN(3), VCL(2)	5192438	27	21	27	14	8	9	4	5	1	0	0.93	1.00
442	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), CASP1(1), CASP7(2), CASP8(1), GAPDH(2), INSR(7), ITCH(2), MAGI1(5), MAGI2(7), RERE(2), WWP1(1)	6378808	32	24	32	10	6	11	6	3	6	0	0.93	1.00
443	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL2RG(1), IL4(2), IL4R(1), IRS1(3), JAK1(1), JAK3(7), RPS6KB1(1), SHC1(1), STAT6(1)	4071928	19	16	19	6	3	9	5	0	2	0	0.93	1.00
444	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(1), ITPKA(1), ITPKB(4)	1687262	6	6	6	2	4	0	1	0	1	0	0.93	1.00
445	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1G(2), CAMK2B(2), CAMK2D(1), CAMK4(3), HDAC5(1), MEF2A(2), MEF2C(3), MEF2D(2), PPARA(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), SLC2A4(2), SYT1(3)	5542920	30	22	30	10	11	5	3	7	4	0	0.93	1.00
446	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(1), FMOD(1)	967608	3	3	3	2	0	2	1	0	0	0	0.93	1.00
447	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	42	ADH1B(1), ADH1C(1), ADH4(2), ADH7(1), ADHFE1(2), AGPAT3(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), CEL(1), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKZ(3), GK(4), GLA(2), LIPC(1), LIPF(1), LIPG(2), LPL(3), PNLIPRP1(3), PNLIPRP2(2), PPAP2B(1)	11725394	54	46	54	25	13	27	5	5	4	0	0.93	1.00
448	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(2), FOS(1), HRAS(1), IL6R(1), JAK1(1), JAK2(3), JAK3(7), JUN(3), MAP2K1(2), MAPK3(1), PTPN11(2), RAF1(1), SHC1(1), SOS1(6), SRF(2), STAT3(1)	6555740	35	28	34	7	8	12	10	3	2	0	0.93	1.00
449	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(1), CBS(4), DNMT1(3), DNMT3A(6), DNMT3B(3), MARS(1), MAT1A(1), MTAP(1), MTR(4), TAT(1)	5640642	26	22	26	11	4	12	6	1	3	0	0.93	1.00
450	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), CHUK(2), IFNG(1), IKBKB(2), IL4(2), JUN(3), MAP3K1(2), MAP3K5(3), MAP4K5(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(2), TNFRSF9(1)	5344806	26	21	25	9	5	6	9	2	4	0	0.93	1.00
451	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	AKT1(1), BRAF(7), CREB1(1), CREB3(2), CREB5(3), CREBBP(12), DAG1(1), EGR1(2), EGR2(6), EGR3(1), FRS2(3), JUN(3), MAP1B(3), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), NTRK1(3), OPN1LW(2), PIK3C2G(6), PIK3CD(3), PIK3R1(1), PTPN11(2), RPS6KA3(1), SHC1(1), TH(1)	13677876	76	53	75	28	24	26	14	6	6	0	0.93	1.00
452	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(2), GOT2(2), PAH(1), TAT(1), YARS(1)	2348888	8	8	8	5	4	2	0	1	1	0	0.93	1.00
453	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT2(2), IARS(3), IARS2(3), ILVBL(2), LARS2(3), PDHA1(2), PDHA2(5), VARS(3), VARS2(1)	5037400	24	20	24	5	4	10	6	1	3	0	0.93	1.00
454	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	GORASP1(1), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MAPKAPK5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PIK3CD(3), PIK3R1(1), SYT1(3), TRAF3(1), TRAF5(2), TRAF6(1)	8770594	39	34	39	10	11	14	3	7	4	0	0.93	1.00
455	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(2), DFFB(2), GZMB(1), TOP2A(2), TOP2B(4)	2721976	11	10	11	5	1	4	4	1	1	0	0.93	1.00
456	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), EPOR(2), FOS(1), HRAS(1), JAK2(3), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PLCG1(1), RAF1(1), SHC1(1), SOS1(6), STAT5A(2)	5861184	28	24	27	5	8	7	8	2	3	0	0.94	1.00
457	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(1), DHRS2(1), LCMT1(2), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), WBSCR22(3)	3890012	17	16	17	2	8	4	2	1	2	0	0.94	1.00
458	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), CRADD(1), DFFB(2), FADD(1), JUN(3), MADD(3), MAP3K1(2), MAP3K7(2), MAPK8(2), PAK1(1), PRKDC(11), RB1(7), SPTAN1(2), TNFRSF1A(2), TRADD(1)	10863874	44	40	43	16	9	15	5	2	13	0	0.94	1.00
459	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	CPO(1), FECH(2), GATA1(2), HBB(2), UROD(1)	2209870	8	8	8	3	2	3	0	1	2	0	0.94	1.00
460	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	144	AKT1(1), AKT3(2), BCL2L1(1), CBL(1), CBLB(4), CCND2(3), CCND3(1), CNTFR(1), CREBBP(12), CSF2RB(5), CSF3R(5), EP300(6), EPOR(2), GH2(2), GHR(2), IFNA1(1), IFNA10(3), IFNA14(1), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA8(2), IFNAR1(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(1), IL10(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL13RA2(1), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL22RA2(1), IL23R(1), IL28B(1), IL2RB(2), IL2RG(1), IL4(2), IL4R(1), IL5RA(2), IL6R(1), IL7R(2), JAK1(1), JAK2(3), JAK3(7), LEPR(10), LIFR(2), MPL(2), MYC(1), OSMR(2), PIAS1(2), PIAS3(2), PIAS4(2), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIM1(2), PRL(1), PRLR(5), PTPN11(2), SOCS2(1), SOCS5(3), SOS1(6), SOS2(5), SPRED1(1), SPRED2(1), STAM(1), STAM2(2), STAT1(2), STAT2(1), STAT3(1), STAT4(4), STAT5A(2), STAT6(1), TYK2(5)	37361666	202	105	200	83	42	71	47	20	22	0	0.94	1.00
461	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(1), CABIN1(1), CAMK2B(2), CAMK4(3), CNR1(2), CREBBP(12), CSNK2A1(2), EGR2(6), EGR3(1), EP300(6), FCER1A(2), FCGR3A(3), FKBP1B(1), FOS(1), GATA3(5), GRLF1(11), GSK3A(3), HRAS(1), ICOS(2), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL1B(1), IL4(2), ITK(2), KPNA5(2), MAPK14(1), MAPK8(2), MAPK9(1), MEF2A(2), MEF2D(2), MYF5(3), NFAT5(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB2(2), NFKBIB(1), NUP214(4), OPRD1(1), P2RX7(1), PAK1(1), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(3), RELA(2), SFN(2), SLA(1), SP1(1), SP3(1), TGFB1(1), TRPV6(3), VAV1(7), VAV2(3), VAV3(1), XPO5(1)	24820854	139	80	138	44	40	32	30	17	20	0	0.94	1.00
462	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	CBL(1), CD3D(1), DAG1(1), EPHB2(4), ITK(2), ITPKA(1), ITPKB(4), LCK(2), LCP2(2), MAPK1(1), NCK1(2), NFAT5(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PLCG1(1), PTPRC(3), RAF1(1), RASGRP1(1), RASGRP3(6), RASGRP4(4), SOS1(6), SOS2(5), VAV1(7), ZAP70(2)	14819924	76	56	76	29	20	23	18	5	10	0	0.94	1.00
463	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(2), EGR2(6), EGR3(1), MAP3K1(2), MYC(1), NFATC2(4), NFKB1(2), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(2), SYT1(3), VIP(1)	7466566	41	29	41	10	14	8	5	8	6	0	0.94	1.00
464	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(2), ATM(6), ATR(12), E2F1(2), HDAC1(2), RB1(7), SKP2(1), TGFB1(1), TGFB2(2)	7767920	35	29	35	7	8	11	5	3	8	0	0.94	1.00
465	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	10	IL6R(1), JAK1(1), JAK2(3), JAK3(7), PIAS3(2), PTPRU(5), STAT3(1)	4136186	20	17	20	3	2	11	4	1	2	0	0.94	1.00
466	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(1), ARHGEF1(2), GNA12(1), GNB1(1), MYL2(1), MYLK(5), PLCB1(6), PPP1R12B(4), PRKCA(4), ROCK1(5)	5569976	30	23	30	9	6	13	6	3	2	0	0.94	1.00
467	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	MARCKS(1), NFATC2(4), NFATC3(2), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), PRKCA(4), SP1(1), SP3(1), SYT1(3)	5691372	26	22	26	5	9	7	2	5	3	0	0.94	1.00
468	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(1), SNAP25(1)	869530	2	2	2	3	0	1	1	0	0	0	0.94	1.00
469	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CARM1(1), CREBBP(12), EP300(6), ERCC3(1), ESR1(5), GRIP1(3), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC1(2), HDAC3(1), HDAC4(4), HDAC5(1), MEF2C(3), NCOR2(6), NR0B1(4), NRIP1(3), POLR2A(1), TBP(1)	12822586	63	48	62	19	18	17	13	7	8	0	0.94	1.00
470	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(1), AKT3(2), DAG1(1), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), PDK1(1), PHKA2(2), PIK3CB(2), PITX2(3), PLD1(6), PLD2(2), PLD3(1), VN1R1(2)	12327212	55	45	55	15	11	21	8	6	9	0	0.95	1.00
471	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	HADH(1), HADHA(2), HSD17B4(1), SIRT2(2), VNN2(5)	3154338	11	10	11	7	0	3	3	1	4	0	0.95	1.00
472	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(1), CASP9(2), CHUK(2), GHR(2), NFKB1(2), PDPK1(1), PIK3R1(1), RELA(2)	3258112	13	11	13	8	1	4	2	4	2	0	0.95	1.00
473	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(1), ACP6(2), ACPT(1), ALPL(3), ALPP(2), ALPPL2(1), CMBL(1), CYP3A4(1), CYP3A43(3), CYP3A7(1), DHRS2(1), PON1(4), PON2(1), PON3(1)	4730528	23	18	23	10	6	8	3	2	4	0	0.95	1.00
474	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(2), ACTN2(6), ACTN3(2), BCAR1(5), BCR(1), CAPN1(2), CAPNS2(1), FYN(3), HRAS(1), ITGA1(3), ITGB1(3), JUN(3), MAP2K1(2), MAPK1(1), MAPK3(1), MAPK8(2), PPP1R12B(4), PTK2(4), PXN(3), RAF1(1), ROCK1(5), SHC1(1), SOS1(6), TLN1(3), VCL(2)	12940422	68	51	67	21	17	22	14	10	5	0	0.95	1.00
475	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(1), IFNB1(1), IKBKB(2), IL1B(1), IL1RAP(2), IRAK1(3), IRAK3(3), JUN(3), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(2), NFKB1(2), RELA(2), TGFB1(1), TGFB2(2), TOLLIP(1), TRAF6(1)	8061264	39	32	38	14	14	10	6	5	4	0	0.95	1.00
476	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR1(2), IFNB1(1), MAPK8(2), NFKB1(2), RELA(2), TNFRSF11A(1), TNFSF11(1), TRAF6(1)	3013540	14	11	14	2	5	4	0	3	2	0	0.95	1.00
477	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), CALML6(1), CAMK2B(2), CAMK2D(1), CREB1(1), CREB3(2), CREB3L2(2), CREB3L3(1), CREB3L4(2), CREBBP(12), CTNNB1(3), DCT(1), DVL1(3), DVL3(2), EDNRB(3), EP300(6), FZD1(1), FZD10(1), FZD3(4), FZD4(1), FZD6(2), FZD7(1), FZD9(2), GNAI1(2), GNAI3(1), GNAS(5), HRAS(1), KIT(5), KRAS(1), LEF1(3), MAP2K1(2), MAPK1(1), MAPK3(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), POMC(1), PRKACB(2), PRKACG(1), PRKCA(4), PRKCG(8), PRKX(1), RAF1(1), TCF7(1), TYR(3), TYRP1(2), WNT10B(2), WNT11(1), WNT2(3), WNT2B(2), WNT3(2), WNT3A(1), WNT6(2), WNT7A(2), WNT7B(1), WNT9A(1), WNT9B(1)	29302182	171	90	170	56	48	60	30	18	15	0	0.95	1.00
478	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	B4GALT1(1), G6PC(2), G6PC2(1), GALK2(1), GALT(1), GANC(3), GCK(1), GLA(2), HK1(3), HK2(5), HK3(5), MGAM(3), PFKL(2), PFKM(4), PFKP(2), RDH11(1), RDH12(2), RDH13(1), UGP2(4)	9542224	44	39	44	16	17	13	5	6	3	0	0.95	1.00
479	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), HADHA(2), SDS(2)	3292822	12	12	12	5	1	6	2	1	2	0	0.96	1.00
480	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	23	B4GALT1(1), FBP2(1), G6PC(2), GALK2(1), GALT(1), GANAB(5), GCK(1), GLA(2), HK1(3), HK2(5), HK3(5), MGAM(3), PFKM(4), PFKP(2)	7869914	36	32	36	15	12	16	3	4	1	0	0.96	1.00
481	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(2), SDHA(1)	1766116	5	5	5	2	0	2	1	2	0	0	0.96	1.00
482	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(1), ALOX12B(1), ALOX15(2), ALOX15B(1), CYP2B6(3), CYP2C19(6), CYP2C8(2), CYP2C9(2), CYP2J2(1), CYP4A22(2), CYP4F2(3), CYP4F3(2), DHRS4(1), EPHX2(2), GGT1(1), GPX5(1), GPX6(2), LTA4H(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PTGES(1), PTGS1(2), TBXAS1(2)	10561808	56	41	56	28	15	13	20	2	6	0	0.96	1.00
483	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(7), EIF2AK4(4), EIF2B5(1), EIF5(1)	3140988	13	13	13	5	7	4	1	0	1	0	0.96	1.00
484	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(1), SRP54(1), SRP72(1), SRPR(2)	2013536	6	6	6	3	2	2	2	0	0	0	0.96	1.00
485	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	30	GTF2A1(1), GTF2B(1), GTF2E1(1), GTF2F1(1), GTF2H4(1), GTF2I(1), GTF2IRD1(4), TAF1(10), TAF2(6), TAF4(1), TAF4B(4), TAF5L(1), TAF6L(1), TAF7L(1), TAF9(2), TBPL2(1)	8734104	37	34	37	10	8	13	6	5	5	0	0.96	1.00
486	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(4), ALDH3B2(1), AOC2(1), AOC3(3), DDC(2), EPX(4), ESCO1(1), GOT2(2), HPD(1), LPO(2), MPO(3), MYST3(9), MYST4(3), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(1)	8770238	40	34	40	22	10	12	11	4	3	0	0.96	1.00
487	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(5), AMY2B(3), ASCC3(9), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(1), DDX41(2), DDX50(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENPP1(7), ENPP3(3), ENTPD7(1), ERCC3(1), G6PC(2), G6PC2(1), GANC(3), GBA3(6), GBE1(1), GCK(1), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(3), HK2(5), HK3(5), IFIH1(3), MGAM(3), NUDT8(1), PYGB(3), PYGM(4), RAD54L(1), SETX(10), SKIV2L2(2), SMARCA2(2), TREH(1), UGDH(2), UGP2(4), UGT1A10(2), UGT1A3(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(3), UGT1A9(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(3), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(2), UXS1(3)	32156056	159	91	159	49	43	52	40	10	14	0	0.96	1.00
488	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	AKT1(1), AKT3(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(7), BTK(4), CDC42(1), CFL1(2), CFL2(1), GDI1(1), GDI2(1), INPPL1(3), ITPR1(4), ITPR2(11), ITPR3(1), MYLK(5), MYLK2(2), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PDK1(1), PIK3CD(3), PIK3CG(9), PIK3R1(1), PITX2(3), PPP1R13B(4), RACGAP1(1), RHO(1), ROCK1(5), ROCK2(3), WASL(2)	18413388	88	63	87	35	17	26	20	9	16	0	0.96	1.00
489	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(3), AKT1(1), GNAS(5), GNB1(1), NFKB1(2), NOS3(1), PIK3R1(1), RELA(2), SYT1(3)	4352634	19	15	19	9	5	4	4	5	1	0	0.96	1.00
490	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(2), ACAD9(3), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), DHRS2(1), ESCO1(1), MYST3(9), MYST4(3), PNPLA3(1), SH3GLB1(1)	6562148	29	26	29	11	7	11	4	2	5	0	0.96	1.00
491	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	56	AADAT(1), ABP1(4), ACAT1(1), ACMSD(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), AOC2(1), AOC3(3), AOX1(9), CARM1(1), CYP1A2(1), DDC(2), GCDH(1), HADH(1), HADHA(2), HSD17B4(1), INMT(2), KMO(2), KYNU(3), LCMT1(2), LNX1(2), NFX1(1), OGDH(3), OGDHL(4), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), TDO2(1), TPH1(1), TPH2(5), WARS(3), WARS2(1), WBSCR22(3)	15932068	79	58	79	31	21	28	14	9	7	0	0.96	1.00
492	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(5), AASDHPPT(1), AASS(6), ACAT1(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(4), EHMT2(1), GCDH(1), HADHA(2), PLOD1(4), PLOD2(4), PLOD3(5), SDS(2)	10099720	48	38	48	23	5	17	16	4	6	0	0.96	1.00
493	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), GCDH(1), HADHA(2), SDS(2)	2113928	6	6	6	7	1	1	2	0	2	0	0.96	1.00
494	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), ARHGDIB(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(3), CASP7(2), CASP8(1), CASP9(2), DFFB(2), GZMB(1), PRF1(1)	5233378	22	19	22	9	3	8	4	2	5	0	0.96	1.00
495	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(6), CDC25B(1), CDC25C(1), CHEK1(4), WEE1(2)	3709342	14	13	14	1	4	6	1	1	2	0	0.97	1.00
496	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(2), BCAR1(5), CAPN1(2), CAPN10(3), CAPN11(2), CAPN2(2), CAPN3(6), CAPN5(2), CAPN6(5), CAPN7(1), CAV2(1), CAV3(1), CDC42(1), DOCK1(3), FYN(3), ILK(1), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(1), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGAD(6), ITGAE(3), ITGAL(1), ITGAM(3), ITGAV(3), ITGAX(9), ITGB1(3), ITGB2(3), ITGB3(3), ITGB4(6), ITGB6(1), ITGB7(1), ITGB8(3), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAPK10(1), MAPK4(1), MAPK6(2), MAPK7(1), MYLK2(2), PAK1(1), PAK3(1), PAK4(1), PDPK1(1), PIK3R2(3), PTK2(4), PXN(3), RAC1(1), RAP1B(1), RAPGEF1(3), RHO(1), ROCK1(5), ROCK2(3), SDCCAG8(5), SHC1(1), SHC3(2), SORBS1(5), SOS1(6), TLN1(3), TNS1(6), VASP(2), VAV2(3), VAV3(1), VCL(2)	36879464	195	104	194	67	45	75	42	13	20	0	0.97	1.00
497	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGEF2(3), COPA(8), GBF1(4), KDELR2(1)	4367764	18	16	18	9	4	4	6	3	1	0	0.97	1.00
498	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(3), COPS5(2), CREB1(1), EP300(6), HIF1A(1), JUN(3), NOS3(1), VHL(1)	4582432	19	17	17	8	2	7	6	3	1	0	0.97	1.00
499	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	CPOX(2), FECH(2), PPOX(1), UROD(1)	2065156	6	6	6	2	1	3	0	1	1	0	0.97	1.00
500	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(2), FADD(1), IKBKB(2), IRAK1(3), MAP3K1(2), MAP3K14(1), MAP3K7(2), NFKB1(2), RELA(2), TNFAIP3(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1)	6253140	25	21	25	10	8	5	4	3	5	0	0.97	1.00
501	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	AKT1(1), DAG1(1), DGKA(3), ETFA(2), GCA(1), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), MAP2K1(2), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(1), PDE3A(4), PDE3B(3), PI3(1), PIK3C2G(6), PIK3CD(3), PIK3R1(1), RIPK3(1), SGCB(1), VASP(2)	12846260	57	46	57	19	19	16	11	3	8	0	0.97	1.00
502	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ARPC1A(2), NCK1(2), NCKAP1(4), NTRK1(3), RAC1(1), WASF3(1), WASL(2)	4129422	16	15	16	11	2	7	2	2	3	0	0.97	1.00
503	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1(1), MST1R(1)	1782314	5	5	5	2	2	2	1	0	0	0	0.97	1.00
504	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1G(2), CAMK2B(2), CAMK2D(1), CAMK4(3), CREB1(1), SYT1(3)	3177478	12	11	12	7	5	1	1	4	1	0	0.97	1.00
505	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1G(2), FPR1(1), GNB1(1), HRAS(1), MAP2K1(2), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAPK1(1), MAPK14(1), MAPK3(1), NCF2(2), NFATC2(4), NFATC3(2), NFATC4(1), NFKB1(2), PAK1(1), PIK3C2G(6), PLCB1(6), PPP3CA(2), PPP3CB(4), PPP3CC(2), RAC1(1), RAF1(1), RELA(2), SYT1(3)	10537956	55	41	55	19	19	16	6	10	4	0	0.97	1.00
506	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(1), DIAPH1(1), FYN(3), GSN(2), HRAS(1), ITGA1(3), ITGB1(3), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(5), PIK3R1(1), PTK2(4), PXN(3), RAF1(1), ROCK1(5), SHC1(1), TLN1(3)	9542402	42	37	42	11	10	12	8	9	3	0	0.97	1.00
507	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPL(3), ALPP(2), ALPPL2(1), GCH1(1)	1834468	7	6	7	4	3	3	0	1	0	0	0.97	1.00
508	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CDC42(1), CREB1(1), CREB3(2), CREB5(3), DUSP10(3), EEF2K(3), GADD45A(1), MAP2K3(2), MAP2K6(2), MAP3K4(4), MAP3K5(3), MAP3K7(2), MAPK1(1), MAPK13(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MKNK2(1), MYEF2(3), NFKB1(2), NR2C2(1), SRF(2), TRAF6(1)	9192632	46	34	46	15	7	15	13	6	5	0	0.97	1.00
509	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(2), CAMK2D(1), DAG1(1), ITPKA(1), ITPKB(4), ITPR1(4), ITPR2(11), ITPR3(1), NFAT5(2), PDE6A(2), PDE6B(3), PDE6H(2), SLC6A13(4), TF(5)	9814920	43	37	43	12	17	9	8	1	8	0	0.97	1.00
510	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	ABP1(4), ADC(1), ALDH18A1(3), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), AMD1(1), AOC2(1), AOC3(3), ARG1(2), ASL(3), GATM(1), NAGS(1), ODC1(1), OTC(2), SMS(2)	7199388	32	26	32	8	10	12	6	2	2	0	0.97	1.00
511	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ7(1), NDUFA13(2)	1115170	3	3	3	2	0	2	1	0	0	0	0.97	1.00
512	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ARPC1A(2), CDC42(1), RAC1(1), WASL(2)	2180856	7	7	7	6	1	3	2	1	0	0	0.97	1.00
513	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(2), B4GALT1(1), B4GALT3(1), B4GALT5(2), DDOST(1), FUT8(2), MAN1A1(3), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(3), RPN1(1), ST6GAL1(1)	5405504	27	21	27	14	11	9	2	3	2	0	0.98	1.00
514	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAK1(1), BAX(1), BCL2L1(1), CASP8AP2(5), CASP9(2), CES1(2)	3102540	13	10	13	5	3	2	5	2	1	0	0.98	1.00
515	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	46	ACCN1(4), ADCY4(3), ADCY8(13), CACNA1A(7), CACNA1B(1), GNAS(5), GNAT3(1), GNB1(1), GRM4(1), ITPR3(1), KCNB1(1), PDE1A(2), PLCB2(5), PRKACB(2), PRKACG(1), PRKX(1), SCNN1B(1), SCNN1G(1), TAS1R1(2), TAS2R1(3), TAS2R10(3), TAS2R16(4), TAS2R38(2), TAS2R39(1), TAS2R4(1), TAS2R40(2), TAS2R41(5), TAS2R42(1), TAS2R5(1), TAS2R7(1), TAS2R8(1), TAS2R9(3)	15289132	81	55	81	34	22	25	20	7	7	0	0.98	1.00
516	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(5), APOC2(2), CYP7A1(3), LDLR(3), LIPC(1), LPL(3), LRP1(10), SCARB1(3)	6764356	30	26	30	15	12	11	5	0	2	0	0.98	1.00
517	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(3), CASP7(2), CASP8(1), CFLAR(1), DAXX(2), DFFB(2), FADD(1), FAF1(1), JUN(3), MAP3K1(2), MAP3K7(2), MAPK8(2), PAK1(1), PRKDC(11), PTPN13(3), RB1(7), RIPK2(1), SPTAN1(2)	11532976	48	40	47	12	10	19	6	2	11	0	0.98	1.00
518	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(4), ELOVL5(2), ELOVL6(1), FADS1(1), FADS2(1), HADHA(2), HSD17B12(1), PECR(1), SCD(1)	4036862	16	14	16	4	3	3	4	2	4	0	0.98	1.00
519	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	IMPA1(1), INPP1(1), INPP4A(5), INPP4B(4), INPP5A(3), INPP5B(5), INPP5E(2), INPPL1(3), ITPK1(1), ITPKA(1), ITPKB(4), OCRL(5), PI4KA(4), PI4KB(1), PIK3C3(3), PIK3CB(2), PIK3CD(3), PIK3CG(9), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(1), PLCB1(6), PLCB2(5), PLCB3(3), PLCB4(4), PLCD3(1), PLCE1(11), PLCG1(1), PLCG2(3), PLCZ1(4), SYNJ1(2), SYNJ2(3)	19558106	113	65	112	34	35	30	21	11	16	0	0.98	1.00
520	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), HBEGF(1), IFNG(1), NR4A3(2), WDR1(1)	2985950	9	9	9	5	1	3	1	2	2	0	0.98	1.00
521	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	137	ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADCY9(3), ADSL(1), ADSS(1), ADSSL1(1), AK5(3), AK7(1), AMPD1(4), AMPD2(1), AMPD3(6), CANT1(1), DCK(1), ENPP1(7), ENPP3(3), ENTPD1(1), ENTPD2(1), ENTPD3(1), ENTPD6(3), GART(1), GUCY1A3(5), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(4), GUK1(2), HPRT1(1), IMPDH1(1), NME4(1), NME7(2), NPR1(2), NPR2(2), NT5C1A(2), NT5C1B(1), NT5C2(2), NT5C3(3), NT5E(2), NUDT9(2), PAPSS2(1), PDE10A(5), PDE11A(8), PDE1A(2), PDE2A(2), PDE3B(3), PDE4A(1), PDE4B(3), PDE4C(2), PDE4D(1), PDE5A(4), PDE6H(2), PDE7B(1), PDE8A(5), PDE8B(2), PDE9A(2), PFAS(4), PKLR(3), PKM2(2), PNPT1(2), POLA1(4), POLD1(2), POLD3(1), POLE2(2), POLE4(1), POLR1A(2), POLR1B(2), POLR1D(1), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(1), PPAT(2), PRIM1(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RFC5(1), RRM1(1), RRM2B(2), XDH(8)	42874326	211	107	211	85	55	78	40	13	25	0	0.98	1.00
522	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT9(1), GCNT2(1), ST8SIA1(2)	1700256	4	4	4	3	1	1	1	0	1	0	0.98	1.00
523	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	58	ATP12A(4), ATP6V0A1(4), ATP6V0A4(2), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C1(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ATP7B(1), COX4I1(1), COX6B1(1), NDUFB5(2), NDUFS1(3), NDUFV1(2), NDUFV2(2), SDHA(1), UQCRB(1)	9402494	37	31	37	12	9	8	11	3	6	0	0.98	1.00
524	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25B(1), CDC25C(1), PRKCA(4)	2502858	7	7	7	3	1	3	1	1	1	0	0.98	1.00
525	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAP3K14(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(2), TNFRSF13B(1), TNFSF13(1), TRAF3(1), TRAF5(2), TRAF6(1)	3974740	16	13	16	7	5	3	1	1	6	0	0.98	1.00
526	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(1), CHUK(2), FOS(1), IKBKB(2), IRAK1(3), JUN(3), MAP2K3(2), MAP2K6(2), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(2), NFKB1(2), PPARA(1), RELA(2), TLR2(3), TLR3(2), TLR7(3), TLR9(1), TOLLIP(1), TRAF6(1)	9458386	40	34	39	12	16	8	6	4	6	0	0.98	1.00
527	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(2), CDC42(1), CREB1(1), DAXX(2), HRAS(1), HSPB2(1), MAP2K6(2), MAP3K1(2), MAP3K5(3), MAP3K7(2), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MEF2A(2), MEF2C(3), MEF2D(2), MYC(1), PLA2G4A(5), RAC1(1), RPS6KA5(4), SHC1(1), STAT1(2), TGFB1(1), TGFB2(2), TRADD(1)	9996480	50	37	50	19	12	15	13	5	5	0	0.98	1.00
528	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BAK1(1), BAX(1), BCL2L1(1), BIRC3(3), CASP7(2), CASP8(1), CASP9(2), DFFB(2)	3689762	14	12	14	5	3	3	3	2	3	0	0.98	1.00
529	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO1(1), ACO2(3), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(1), IDH3B(3), IDH3G(1), MDH1(1), MDH2(1), OGDH(3), OGDHL(4), PC(2), PCK1(1), PCK2(1), SDHA(1), SUCLA2(2), SUCLG2(1)	8013026	33	29	33	17	7	11	4	6	5	0	0.98	1.00
530	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(2), ATM(6), BRCA1(6), CHEK1(4), CHEK2(3), GADD45A(1), JUN(3), MAPK8(2), MDM2(1), NFKB1(2), RAD50(2), RAD51(1), RBBP8(1), RELA(2)	7873474	36	28	35	6	6	13	3	8	6	0	0.98	1.00
531	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(2), EXT2(1), EXTL1(1), EXTL3(1), HS3ST2(1), HS3ST5(4), HS6ST1(2), HS6ST3(2), NDST1(2), NDST2(1), NDST3(4)	5246906	21	19	21	11	2	10	4	5	0	0	0.98	1.00
532	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(2), ACTN2(6), ACTN3(2), CAPN1(2), CAPNS2(1), ITGA1(3), ITGB1(3), ITGB3(3), PTK2(4), PXN(3), RAC1(1), SPTAN1(2), TLN1(3)	7784474	36	28	36	17	12	9	4	7	4	0	0.98	1.00
533	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(1), GHR(2), HRAS(1), IGF1(3), PIK3R1(1), SHC1(1), SOD2(1)	3007310	10	9	10	5	2	5	1	2	0	0	0.98	1.00
534	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	35	ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACAT1(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH6A1(1), ALDH9A1(2), AOX1(9), BCKDHB(2), HADHA(2), HADHB(2), HMGCL(1), MCCC1(4), MUT(1), OXCT1(2), PCCA(2), SDS(2)	9417980	43	35	43	13	5	18	9	7	4	0	0.98	1.00
535	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22(1), IL22RA2(1), JAK1(1), JAK2(3), JAK3(7), STAT1(2), STAT3(1), STAT5A(2), TYK2(5)	5072466	23	18	23	8	5	10	5	1	2	0	0.98	1.00
536	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(1), CBS(4), GGT1(1), LCMT1(2), MARS(1), MAT1A(1), PAPSS2(1), PRMT3(2), PRMT5(1), PRMT6(2), PRMT7(4), PRMT8(1), SEPHS1(3), WBSCR22(3)	6761864	28	25	28	9	10	10	2	1	5	0	0.98	1.00
537	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(1), ATF2(2), CDC42(1), DLD(2), DUSP10(3), DUSP4(2), GAB1(2), GADD45A(1), GCK(1), JUN(3), MAP2K5(1), MAP3K1(2), MAP3K11(2), MAP3K12(3), MAP3K13(5), MAP3K4(4), MAP3K5(3), MAP3K7(2), MAP3K9(3), MAPK10(1), MAPK7(1), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(2), NR2C2(1), PAPPA(8), SHC1(1), TRAF6(1)	13536722	64	49	63	21	15	24	14	7	4	0	0.99	1.00
538	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(1), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), CYP2C19(6), CYP2C9(2), DHRS2(1), ESCO1(1), HADHA(2), MYST3(9), MYST4(3), PNPLA3(1), SH3GLB1(1)	8198324	34	29	34	15	8	12	6	2	6	0	0.99	1.00
539	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(1), BAK1(1), BAX(1), BCL2L1(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(1), CASP9(2), FADD(1), FAS(1), FASLG(1), GZMB(1), JUN(3), MAP3K1(2), MAP3K14(1), MAPK10(1), MCL1(2), MDM2(1), MYC(1), NFKB1(2), PARP1(3), PRF1(1), RELA(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4)	10022112	44	33	43	20	10	12	6	8	8	0	0.99	1.00
540	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), GART(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3), MTHFR(1), MTR(4)	4817926	17	16	17	6	3	3	8	2	1	0	0.99	1.00
541	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(2), IKBKAP(2), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(2), RELA(2), TNFAIP3(3), TRAF3(1), TRAF6(1)	4931312	18	14	18	7	5	2	4	2	5	0	0.99	1.00
542	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CDC25B(1), CDC25C(1), CDK7(1), XPO1(2)	2376300	6	6	6	4	0	2	1	3	0	0	0.99	1.00
543	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(1), AKT3(2), BRD4(2), CAP1(2), CBL(1), CDC42(1), F2RL2(1), FLOT1(1), GSK3A(3), INPPL1(3), IRS1(3), IRS2(2), IRS4(2), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(5), PARD6A(1), PDK1(1), PIK3CD(3), PIK3R1(1), PPYR1(3), PTPN1(1), RAF1(1), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KB1(1), SERPINB6(4), SFN(2), SHC1(1), SLC2A4(2), SORBS1(5), SOS1(6), SOS2(5), YWHAB(1), YWHAQ(1)	15227900	78	51	78	19	13	26	20	7	12	0	0.99	1.00
544	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), CSF1(2), IL4(2)	1697764	5	4	5	5	1	2	1	0	1	0	0.99	1.00
545	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), ADSS(1), HPRT1(1), IMPDH1(1), MTHFD2(3), POLB(1), POLD1(2), POLG(1), PRPS2(1), RRM1(1)	3494318	13	11	13	3	3	5	3	1	1	0	0.99	1.00
546	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GALT6(1), B3GAT1(2), B3GAT2(2), CHPF(1), CHST12(1), CHST3(2), DSE(1), XYLT1(2)	4030810	12	11	12	9	1	4	3	2	2	0	0.99	1.00
547	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(2), ALOX15B(1), GGT1(1), LTA4H(2), PLA2G2A(1), PLA2G6(5), PTGES(1), PTGS1(2), TBXAS1(2)	4144552	17	14	17	6	4	9	4	0	0	0	0.99	1.00
548	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(4), GGT1(1), MARS(1), MAT1A(1), PAPSS2(1), SEPHS1(3)	3369540	12	10	12	7	3	6	0	0	3	0	0.99	1.00
549	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), CASP8(1), FADD(1), MAP2K1(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(2), NSMAF(2), RAF1(1), RELA(2), SMPD1(3), TNFRSF1A(2), TRADD(1)	5630140	24	18	24	10	8	6	5	2	3	0	0.99	1.00
550	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(1), BAK1(1), BAX(1), BCL2L1(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(3), CASP7(2), CASP8(1), CASP9(2), CHUK(2), DFFB(2), FADD(1), FAS(1), FASLG(1), GZMB(1), IKBKB(2), IRF1(1), IRF3(1), IRF4(2), IRF6(5), JUN(3), LTA(2), MAP3K1(2), MAPK10(1), MDM2(1), MYC(1), NFKB1(2), NFKBIB(1), PRF1(1), RELA(2), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TRADD(1), TRAF1(4), TRAF3(1)	15460190	68	47	67	23	13	16	14	10	15	0	0.99	1.00
551	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(1), BCR(1), FOS(1), HRAS(1), JAK2(3), JUN(3), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8(2), MYC(1), PIK3R1(1), RAF1(1), SOS1(6), STAT1(2), STAT5A(2)	6979024	30	25	29	6	7	8	9	4	2	0	0.99	1.00
552	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(1), CABIN1(1), CAMK1G(2), HDAC5(1), IGF1(3), INSR(7), MAP2K6(2), MAPK14(1), MAPK7(1), MEF2A(2), MEF2C(3), MEF2D(2), NFATC2(4), PIK3R1(1), PPP3CA(2), PPP3CB(4), PPP3CC(2), SYT1(3)	8922784	42	30	42	14	10	13	7	8	4	0	0.99	1.00
553	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP4(1), BMP5(5), CSNK1A1(2), CSNK1A1L(5), CSNK1G1(2), DHH(1), GLI1(1), GLI2(4), GLI3(6), HHIP(1), IHH(1), PRKACB(2), PRKACG(1), PRKX(1), PTCH1(4), PTCH2(5), SMO(1), STK36(2), SUFU(2), WNT10B(2), WNT11(1), WNT2(3), WNT2B(2), WNT3(2), WNT3A(1), WNT6(2), WNT7A(2), WNT7B(1), WNT9A(1), WNT9B(1)	14282186	65	49	65	29	17	19	12	10	7	0	0.99	1.00
554	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	ACHE(2), AGPAT3(1), CDS1(2), CHAT(2), CHKA(2), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKZ(3), ETNK1(3), GPD1(1), GPD2(2), LYPLA1(3), PAFAH1B1(1), PCYT1B(1), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLCB2(5), PLCG1(1), PLCG2(3), PPAP2B(1)	13763316	64	48	64	24	16	24	13	5	6	0	0.99	1.00
555	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), NR1I3(1), PTGS1(2)	1417058	4	3	4	4	1	2	0	1	0	0	0.99	1.00
556	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(2), POLG(1), POLL(1), POLQ(12)	4560360	17	15	17	3	4	6	3	3	1	0	0.99	1.00
557	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	ATF2(2), BRAF(7), CEBPA(1), CHUK(2), CREB1(1), DAXX(2), FOS(1), HRAS(1), IKBKB(2), JUN(3), MAP2K1(2), MAP2K3(2), MAP2K5(1), MAP2K6(2), MAP3K1(2), MAP3K11(2), MAP3K12(3), MAP3K13(5), MAP3K14(1), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K7(2), MAP3K9(3), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(5), MAP4K5(1), MAPK1(1), MAPK10(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK4(1), MAPK6(2), MAPK7(1), MAPK8(2), MAPK9(1), MAPKAPK2(1), MAPKAPK5(3), MEF2A(2), MEF2C(3), MEF2D(2), MKNK2(1), MYC(1), NFKB1(2), PAK1(1), RAC1(1), RAF1(1), RELA(2), RPS6KA1(2), RPS6KA2(3), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KB1(1), SHC1(1), SP1(1), STAT1(2), TGFB1(1), TGFB2(2), TRADD(1)	26589284	122	77	120	42	30	35	26	14	17	0	0.99	1.00
558	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(1), EIF2B5(1), IGF1(3), INPPL1(3), PDK2(1), PDPK1(1), PIK3R1(1), RPS6(1), RPS6KB1(1)	4542560	13	13	13	7	0	4	2	3	4	0	0.99	1.00
559	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(1), PSMB8(2)	2341234	6	6	6	3	2	2	1	0	1	0	0.99	1.00
560	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG13(6), ALG2(2), ALG5(2), ALG6(2), B4GALT1(1), B4GALT3(1), DDOST(1), FUT8(2), GANAB(5), MAN1A1(3), MAN1A2(3), MAN1C1(3), MAN2A1(3), MGAT1(1), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(4), RPN1(1), ST6GAL1(1), STT3B(1)	11591360	55	39	55	21	18	20	5	6	6	0	0.99	1.00
561	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1A(3)	1683524	3	3	3	1	2	0	0	1	0	0	0.99	1.00
562	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(6), ATR(12), BRCA1(6), BRCA2(7), CHEK1(4), CHEK2(3), FANCC(2), FANCF(3), FANCG(1), RAD1(1), RAD17(2), RAD50(2), RAD51(1), RAD9A(1), TREX1(1)	11625002	52	39	52	10	11	16	9	8	8	0	0.99	1.00
563	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	MDH1(1), PC(2), PDHA1(2), SLC25A11(1)	2508910	6	6	6	4	0	3	0	2	1	0	0.99	1.00
564	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALT1(2), B3GALT2(2), B3GALT4(1), B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(1), B4GALT4(1), B4GALT6(1), FUT3(3), FUT5(4), FUT6(2), FUT9(1), GBGT1(2), GCNT2(1), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(1), PIGQ(1), PIGX(1), PIGZ(2), ST3GAL1(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC3(3), ST6GALNAC5(2), ST8SIA1(2)	13400908	56	44	56	31	14	12	17	6	7	0	0.99	1.00
565	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(8), ACSL1(2), ACSL3(1), ACSL6(1), ADIPOQ(1), ADIPOR2(2), AKT1(1), AKT3(2), CD36(1), CHUK(2), CPT1A(3), CPT1C(3), CPT2(1), G6PC(2), G6PC2(1), IKBKB(2), IRS1(3), IRS2(2), IRS4(2), JAK1(1), JAK2(3), JAK3(7), LEPR(10), MAPK10(1), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), NFKBIB(1), PCK1(1), PCK2(1), POMC(1), PPARA(1), PPARGC1A(5), PRKAA2(3), PRKAG2(4), PRKAG3(2), PRKCQ(4), PTPN11(2), RELA(2), RXRA(1), RXRG(4), SLC2A4(2), STAT3(1), STK11(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TYK2(5)	22732024	116	71	115	32	37	40	21	7	11	0	0.99	1.00
566	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(1), CASP9(2), DAXX(2), FAS(1), FASLG(1), HSPB2(1), MAPKAPK2(1)	3068186	10	9	10	9	4	2	2	1	1	0	0.99	1.00
567	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(2), MAP3K14(1), NFKB1(2), RELA(2)	2511402	7	5	7	0	1	1	1	1	3	0	0.99	1.00
568	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(1), ACAT1(1), ADH5(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(1), HAGHL(1), LDHB(2), LDHC(1), MDH1(1), MDH2(1), ME2(2), ME3(1), PC(2), PCK1(1), PDHA1(2), PDHA2(5), PKLR(3), PKM2(2)	9689252	39	34	39	19	8	17	5	5	4	0	0.99	1.00
569	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), GART(1), MTHFD1(3), MTHFD1L(2), MTHFD2(3), MTHFR(1), MTR(4)	5119102	17	16	17	6	3	3	8	2	1	0	0.99	1.00
570	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(2), ACTN1(2), AKT1(1), AKT3(2), ARHGEF6(2), ARHGEF7(3), BCAR1(5), BRAF(7), CDC42(1), CSE1L(4), DOCK1(3), EPHB2(4), FYN(3), GRLF1(11), ILK(1), ITGA1(3), ITGA10(5), ITGA11(3), ITGA2(5), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(3), ITGA8(8), ITGB3BP(1), MAP3K11(2), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MRAS(2), MYLK(5), MYLK2(2), PAK1(1), PAK3(1), PAK4(1), PAK7(4), PIK3CB(2), PKLR(3), PLCG1(1), PLCG2(3), PTK2(4), RAF1(1), RALA(2), RHO(1), ROCK1(5), ROCK2(3), SHC1(1), SOS1(6), SOS2(5), TLN1(3), TLN2(11), VASP(2), WAS(4)	32546588	171	92	171	60	38	64	36	9	24	0	1.00	1.00
571	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), EPOR(2), GRIN1(1), HIF1A(1), JAK2(3), NFKB1(2), RELA(2), SOD2(1)	3452132	13	9	13	1	3	3	3	1	3	0	1.00	1.00
572	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(12), CTBP1(1), DLL1(1), DLL3(1), DLL4(1), DTX2(2), DTX3(2), DTX3L(1), DTX4(1), DVL1(3), DVL3(2), EP300(6), HDAC1(2), JAG2(1), LFNG(1), MAML1(2), MAML2(5), MFNG(1), NCOR2(6), NCSTN(3), NOTCH1(10), NOTCH2(6), NOTCH3(4), NOTCH4(3), PSEN1(1), PSEN2(2), PSENEN(1), SNW1(2)	19396660	83	62	82	28	21	25	16	6	15	0	1.00	1.00
573	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNE2(2), E2F1(2), PRB1(2)	2268254	6	6	6	1	1	5	0	0	0	0	1.00	1.00
574	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC3(3), CASP8(1), CFLAR(1), FADD(1), JUN(3), MAP3K7(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), NR2C2(1), RALBP1(1), TNFAIP3(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	7490062	31	23	30	13	6	10	4	7	4	0	1.00	1.00
575	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS2(1), ESCO1(1), MYST3(9), MYST4(3), PNPLA3(1), SH3GLB1(1)	4289088	16	13	16	8	3	6	3	1	3	0	1.00	1.00
576	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	30	ABAT(2), ACACA(1), ACADL(2), ACADM(1), ACAT1(1), ALDH1A2(2), ALDH1B1(2), ALDH2(2), ALDH6A1(1), ALDH9A1(2), HADHA(2), LDHB(2), LDHC(1), MLYCD(1), MUT(1), PCCA(2), SDS(2), SUCLA2(2), SUCLG2(1)	8608970	30	29	30	11	4	15	5	2	4	0	1.00	1.00
577	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(5), CRY1(1), CRY2(2), PER1(4), PER2(2), PER3(1)	4651140	17	14	17	9	0	8	7	1	1	0	1.00	1.00
578	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	43	ABAT(2), ACAA2(1), ACADM(1), ACADS(2), ACAT1(1), ALDH1B1(2), ALDH2(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), AOX1(9), AUH(1), BCAT2(2), BCKDHB(2), DBT(1), DLD(2), HADH(1), HADHA(2), HADHB(2), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), MCCC1(4), MUT(1), OXCT1(2), PCCA(2)	11384524	51	38	51	14	10	16	10	9	6	0	1.00	1.00
579	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BNIP1(1), GOSR1(1), SEC22B(4), SNAP25(1), STX10(1), STX11(1), STX5(2), STX7(1), TSNARE1(1), USE1(1), YKT6(1)	4427750	15	14	15	9	3	5	4	2	1	0	1.00	1.00
580	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT2(1), AOC2(1), AOC3(3), CBS(4), CHDH(1), CHKA(2), DAO(1), DLD(2), DMGDH(1), GATM(1), GLDC(4), GNMT(1), PHGDH(2), PIPOX(1), PISD(1), PSAT1(1), PSPH(1), RDH11(1), RDH12(2), RDH13(1), SARDH(4), SARS(2), SARS2(2), SDS(2), TARS(3), TARS2(2)	11695846	51	38	51	18	12	18	12	4	5	0	1.00	1.00
581	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST2(1), XYLT1(2)	1890716	3	3	3	3	0	2	1	0	0	0	1.00	1.00
582	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST2(1), XYLT1(2)	1890716	3	3	3	3	0	2	1	0	0	0	1.00	1.00
583	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), PGAP1(3), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(1), PIGQ(1), PIGX(1), PIGZ(2)	6629788	22	19	22	15	4	3	5	6	4	0	1.00	1.00
584	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(2), AGPAT3(1), AGPAT6(1), CDS1(2), CHAT(2), CHKA(2), CRLS1(1), DGKA(3), DGKB(3), DGKD(5), DGKE(3), DGKG(1), DGKI(7), DGKZ(3), ESCO1(1), ETNK1(3), GPAM(2), GPD1(1), GPD1L(1), GPD2(2), LYPLA1(3), MYST3(9), MYST4(3), PCYT1B(1), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(1), PLA2G3(2), PLA2G4A(5), PLA2G6(5), PLD1(6), PLD2(2), PNPLA3(1), PPAP2B(1), PTDSS1(1), SH3GLB1(1)	18018050	91	58	91	38	21	35	17	7	11	0	1.00	1.00
585	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDPS(1), IDI1(1), MVD(1), SC5DL(1), SQLE(2)	3072458	8	8	8	4	2	3	2	1	0	0	1.00	1.00
586	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(2), FDPS(1), HMGCS1(1), IDI1(1), MVD(1), NSDHL(1), SC5DL(1), SQLE(2)	3632980	10	10	10	4	2	4	2	2	0	0	1.00	1.00
587	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(1), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(1), EEF2K(3), EIF2AK3(7), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF4A1(4), EIF4A2(2), EIF4G1(6), EIF4G3(3), EIF5(1), EIF5B(1), ETF1(1), KIAA0664(1), PABPC1(2), PABPC3(6), PAIP1(1), SLC35A4(1)	12059144	49	41	49	19	9	17	15	3	5	0	1.00	1.00
588	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(1), PSMC2(4), PSMC3(1), PSMD1(2), PSMD11(1), PSMD12(1), PSMD13(1)	4277518	14	13	14	6	5	6	2	0	1	0	1.00	1.00
589	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(1), APAF1(1), ATM(6), BAX(1), BCL2L1(1), CASP7(2), CASP9(2), PRKCA(4), PTK2(4), PXN(3), STAT1(2), TLN1(3)	7230004	30	23	30	9	9	9	6	4	2	0	1.00	1.00
590	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(1), BCL2L1(1), CBL(1), CFLAR(1), E2F1(2), FOS(1), HRAS(1), IL2RB(2), IL2RG(1), IRS1(3), JAK1(1), JAK3(7), MAPK1(1), MAPK3(1), MYC(1), NMI(1), PIK3R1(1), RAF1(1), RPS6KB1(1), SHC1(1), SOS1(6), STAT5A(2), SYK(1)	9289642	39	30	39	12	7	16	9	3	4	0	1.00	1.00
591	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	107	ADCY1(7), ADCY3(4), ADCY4(3), ADCY5(1), ADCY7(4), ADCY8(13), ADSL(1), ADSS(1), AK5(3), AMPD1(4), AMPD2(1), AMPD3(6), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5G2(2), ATP5G3(1), CANT1(1), DCK(1), ENPP1(7), ENPP3(3), ENTPD1(1), ENTPD2(1), GART(1), GUCY1A3(5), GUCY1B3(3), GUCY2C(4), GUCY2D(1), GUCY2F(4), GUK1(2), HPRT1(1), IMPDH1(1), NPR1(2), NPR2(2), NT5E(2), PAPSS2(1), PDE1A(2), PDE4A(1), PDE4B(3), PDE4C(2), PDE4D(1), PDE5A(4), PDE6B(3), PDE7B(1), PDE8A(5), PDE9A(2), PFAS(4), PKLR(3), PKM2(2), POLB(1), POLD1(2), POLG(1), POLL(1), POLQ(12), POLR1B(2), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), PPAT(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RRM1(1)	33964892	163	92	163	56	40	64	30	12	17	0	1.00	1.00
592	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(4), AGXT2(1), AOC2(1), AOC3(3), CBS(4), CHDH(1), CHKA(2), DAO(1), DLD(2), DMGDH(1), GATM(1), GLDC(4), PISD(1), PLCB2(5), PLCG1(1), PLCG2(3), PSPH(1), SARDH(4), SARS(2), TARS(3)	11524254	45	36	45	15	12	15	11	3	4	0	1.00	1.00
593	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACAT1(1), ACOX1(2), ACOX3(4), ACSL1(2), ACSL3(1), ACSL6(1), ADH1B(1), ADH1C(1), ADH4(2), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), CPT1A(3), CPT1C(3), CPT2(1), CYP4A22(2), DCI(1), GCDH(1), HADH(1), HADHA(2), HADHB(2), HSD17B4(1), PECI(1)	13166660	51	43	51	18	11	18	10	8	4	0	1.00	1.00
594	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10(1), JAK1(1), STAT1(2), STAT3(1), STAT5A(2)	3285880	9	8	9	5	2	4	2	1	0	0	1.00	1.00
595	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL10L(3), RPL14(1), RPL19(1), RPL32(1), RPL37(1), RPL3L(1), RPL7(1), RPL8(2), RPS11(1), RPS18(1), RPS2(1), RPS21(1), RPS26(1), RPS6(1), RPS8(1)	6262930	18	18	18	11	4	4	6	3	1	0	1.00	1.00
596	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	32	ABAT(2), ACACA(1), ACACB(8), ACADM(1), ACAT1(1), ACSS1(3), ALDH1B1(2), ALDH2(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), HADHA(2), HIBCH(1), LDHAL6B(1), LDHB(2), LDHC(1), MLYCD(1), MUT(1), PCCA(2), SUCLA2(2), SUCLG2(1)	10380782	38	33	38	15	10	16	4	3	5	0	1.00	1.00
597	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(1), ACACB(8), ACAT1(1), ACOT12(1), ACSS1(3), ALDH1B1(2), ALDH2(2), ALDH7A1(1), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(1), HAGHL(1), LDHAL6B(1), LDHB(2), LDHC(1), MDH1(1), MDH2(1), ME2(2), ME3(1), PC(2), PCK1(1), PCK2(1), PDHA1(2), PDHA2(5), PKLR(3), PKM2(2)	12317066	51	40	51	25	15	21	5	5	5	0	1.00	1.00
598	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(6), CCNB1(1), CCND2(3), CCND3(1), CCNE2(2), CDK7(1), CDKN2C(1), CREB3(2), CREB3L3(1), CREB3L4(2), E2F1(2), GADD45A(1), MCM2(1), MCM3(1), MCM4(3), MCM5(6), MCM6(1), MCM7(3), MDM2(1), MYC(1), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), POLE2(2), PRIM1(2), RB1(7), RBL1(5), TFDP2(2), TNXB(15), WEE1(2)	20615604	79	60	79	17	17	29	12	7	14	0	1.00	1.00
599	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	22	ARSB(1), ARSD(1), ARSE(2), GAL3ST1(1), GALC(1), GLA(2), NEU1(2), NEU2(2), PPAP2B(1), SMPD1(3), SMPD2(1), SPTLC2(3)	5598812	20	16	20	7	6	7	4	2	1	0	1.00	1.00
600	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP1(1), ARHGAP4(1), ARHGAP5(1), ARHGAP6(5), ARHGEF1(2), ARHGEF11(7), ARHGEF5(1), ARPC1A(2), CFL1(2), DIAPH1(1), GSN(2), MYL2(1), MYLK(5), OPHN1(1), PIP5K1A(3), PIP5K1B(2), PPP1R12B(4), ROCK1(5), TLN1(3), VCL(2)	12577124	51	40	50	14	8	20	13	7	3	0	1.00	1.00
601	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(1), ACACB(8), MCAT(1), OLAH(1), OXSM(1)	4429352	12	11	12	8	6	4	1	0	1	0	1.00	1.00
602	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(2), FDPS(1), GGPS1(2), HSD17B7(1), IDI1(1), IDI2(2), MVD(1), NSDHL(1), SC5DL(1), SQLE(2), TM7SF2(1)	5284998	15	14	15	5	4	5	4	2	0	0	1.00	1.00
603	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(1), ACOT11(1), DHRS2(1), ESCO1(1), GCDH(1), HADHA(2), MYST3(9), MYST4(3), PNPLA3(1), SH3GLB1(1)	6846592	21	18	21	13	4	7	4	1	5	0	1.00	1.00
604	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), DFFB(2), FADD(1), GAS2(2), MAP3K14(1), NFKB1(2), RELA(2), SPTAN1(2), TNFRSF10A(1), TNFRSF10B(1), TRADD(1)	9154184	30	24	30	12	7	8	3	5	7	0	1.00	1.00
605	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(2), BAK1(1), BAX(1), BTK(4), CAD(8), CASP10(3), CASP8(1), CASP8AP2(5), CDK2AP1(1), CSNK1A1(2), DAXX(2), EGFR(6), EPHB2(4), FADD(1), FAF1(1), FAIM2(1), MAP3K1(2), MAP3K5(3), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MET(3), NFAT5(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIL1(1), NFKBIL2(4), NR0B2(1), PFN2(1), PTPN13(3), RALBP1(1), ROCK1(5), SMPD1(3), TNFRSF6B(1)	20075552	88	56	87	24	21	31	18	7	11	0	1.00	1.00
606	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(4), ANAPC4(3), ANAPC5(4), CDC27(2), CUL1(2), ITCH(2), RBX1(1), SKP1(1), SKP2(1), SMURF1(2), UBA1(3), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2E2(1), UBE2E3(1), VHL(1), WWP1(1)	10101144	32	29	32	9	7	9	5	6	5	0	1.00	1.00
607	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(2), CDC40(2), CLK2(1), CLK3(1), CLK4(2), COL2A1(8), CPSF1(3), CPSF2(2), CPSF3(1), CPSF4(1), CSTF2(2), CSTF2T(2), CSTF3(1), DDX1(5), DHX15(2), DHX16(1), DHX38(1), DHX8(1), DHX9(5), DICER1(7), FUS(1), METTL3(1), NCBP1(2), NXF1(1), PAPOLA(1), POLR2A(1), PRPF3(1), PRPF4(2), PRPF4B(5), PRPF8(5), PSKH1(1), PTBP2(1), RBM17(1), RBM5(1), RNPS1(1), SF3A1(1), SF3A2(2), SF3A3(2), SF3B1(2), SF3B2(2), SF3B4(1), SF4(2), SFRS12(1), SFRS14(4), SFRS2(2), SFRS6(1), SFRS8(2), SNRPA(2), SNRPB(3), SNRPD1(1), SNRPD2(1), SNRPN(1), SPOP(1), SRPK1(2), SRRM1(2), SUPT5H(2), XRN2(2)	28537138	114	74	112	30	26	32	33	10	13	0	1.00	1.00
608	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	84	AICDA(2), CAD(8), CANT1(1), CDA(1), CTPS(2), CTPS2(2), DCK(1), DPYD(7), DPYS(4), ENTPD1(1), ENTPD3(1), ENTPD6(3), NME4(1), NME7(2), NT5C1A(2), NT5C1B(1), NT5C2(2), NT5C3(3), NT5E(2), PNPT1(2), POLA1(4), POLD1(2), POLD3(1), POLE2(2), POLE4(1), POLR1A(2), POLR1B(2), POLR1D(1), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(1), PRIM1(2), RFC5(1), RRM1(1), RRM2B(2), TXNRD1(2), TXNRD2(2), UMPS(1), UPP1(3), UPP2(1), UPRT(1)	21837574	89	60	88	35	17	33	18	6	15	0	1.00	1.00
609	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1)	3743518	7	6	7	2	2	1	0	1	3	0	1.00	1.00
610	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(4), CDC7(1), DIAPH2(1), GMNN(2), MCM10(3), MCM2(1), MCM3(1), MCM4(3), MCM5(6), MCM6(1), MCM7(3), ORC1L(1), ORC2L(1), ORC3L(1), ORC5L(1), POLD1(2), POLD3(1), POLE2(2), PRIM1(2), RFC1(1), RFC4(3), RFC5(1), RPA4(2), UBB(1), UBC(1)	13878660	46	38	46	15	11	13	14	1	7	0	1.00	1.00
611	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(4), POLB(1), POLD1(2), POLD3(1), POLE2(2), POLE4(1), POLG(1), POLG2(1), POLI(2), POLK(3), POLL(1), POLQ(12), PRIM1(2), REV1(5), REV3L(3), RFC5(1)	10953230	42	30	42	13	12	10	12	4	4	0	1.00	1.00
612	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	CAD(8), CANT1(1), CDA(1), CTPS(2), CTPS2(2), DCK(1), DPYD(7), DPYS(4), ENTPD1(1), NT5E(2), POLB(1), POLD1(2), POLG(1), POLL(1), POLQ(12), POLR1B(2), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), RRM1(1), TXNRD1(2), UMPS(1), UPP1(3)	15680732	60	43	60	12	11	23	11	6	9	0	1.00	1.00
613	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(2), POLR1B(2), POLR1D(1), POLR2A(1), POLR2B(2), POLR2D(1), POLR2E(1), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(1)	6292478	15	13	15	12	5	4	1	2	3	0	1.00	1.00
614	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(1), ERCC3(1), GTF2B(1), GTF2E1(1), GTF2H4(1), ILK(1), POLR1A(2), POLR1B(2), POLR2A(1), POLR2B(2), POLR2E(1), POLR3B(2), POLR3D(1), POLR3E(2), POLR3H(1), TAF9(2), TBP(1)	9538486	23	19	23	14	7	4	3	3	6	0	1.00	1.00
615	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPL(3), ALPP(2), ALPPL2(1), ASCC3(9), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(1), DDX41(2), DDX50(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENTPD7(1), ERCC3(1), GCH1(1), IFIH1(3), NUDT8(1), RAD54L(1), SETX(10), SKIV2L2(2), SMARCA2(2)	17193732	54	37	54	23	14	21	12	3	4	0	1.00	1.00
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		407442	0	0	0	0	0	0	0	0	0	0	1.00	1.00
