E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.009 0.133 -9999.0 0.0 -0.407 49.0 49.0 KLHL20 -0.012 0.085 -9999.0 0.0 -0.194 67.0 67.0 CYFIP2 0.02 0.018 -9999.0 0.0 -0.122 8.0 8.0 Rac1/GDP 0.012 0.091 -9999.0 0.0 -0.225 55.0 55.0 ENAH -0.01 0.132 -9999.0 0.0 -0.402 50.0 50.0 AP1M1 0.021 0.017 -9999.0 0.0 -0.122 8.0 8.0 RAP1B 0.019 0.02 -9999.0 0.0 -0.122 10.0 10.0 RAP1A 0.021 0.012 -9999.0 0.0 -0.122 3.0 3.0 CTNNB1 0.022 0.008 -9999.0 0.0 -0.122 1.0 1.0 CDC42/GTP 0.011 0.07 -9999.0 0.0 -0.203 34.0 34.0 ABI1/Sra1/Nap1 -0.028 0.049 -9999.0 0.0 -0.137 73.0 73.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.038 0.055 -9999.0 0.0 -0.105 63.0 63.0 RAPGEF1 -0.0 0.113 -9999.0 0.0 -0.341 49.0 49.0 CTNND1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.01 0.134 -9999.0 0.0 -0.414 49.0 49.0 CRK -0.005 0.122 -9999.0 0.0 -0.372 49.0 49.0 E-cadherin/gamma catenin/alpha catenin 0.025 0.06 -9999.0 0.0 -0.133 61.0 61.0 alphaE/beta7 Integrin 0.026 0.035 -9999.0 0.0 -0.109 33.0 33.0 IQGAP1 0.02 0.017 -9999.0 0.0 -0.122 7.0 7.0 NCKAP1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.015 0.059 -9999.0 0.0 -0.112 85.0 85.0 DLG1 -0.01 0.134 -9999.0 0.0 -0.413 49.0 49.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.022 0.05 -9999.0 0.0 -0.156 53.0 53.0 MLLT4 0.014 0.032 -9999.0 0.0 -0.122 29.0 29.0 ARF6/GTP/NME1/Tiam1 0.018 0.056 -9999.0 0.0 -0.111 71.0 71.0 PI3K -0.028 0.065 -9999.0 0.0 -0.2 53.0 53.0 ARF6 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.017 0.054 -9999.0 0.0 -0.155 44.0 44.0 TIAM1 0.015 0.032 -9999.0 0.0 -0.122 28.0 28.0 E-cadherin(dimer)/Ca2+ 0.033 0.061 -9999.0 0.0 -0.118 67.0 67.0 AKT1 0.005 0.049 -9999.0 0.0 -0.118 51.0 51.0 PIK3R1 0.015 0.031 -9999.0 0.0 -0.122 27.0 27.0 CDH1 0.02 0.016 -9999.0 0.0 -0.122 6.0 6.0 RhoA/GDP 0.013 0.091 -9999.0 0.0 -0.223 55.0 55.0 actin cytoskeleton organization -0.007 0.064 -9999.0 0.0 -0.142 67.0 67.0 CDC42/GDP 0.013 0.091 -9999.0 0.0 -0.224 54.0 54.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.001 0.08 -9999.0 0.0 -0.191 66.0 66.0 ITGB7 0.019 0.024 -9999.0 0.0 -0.122 15.0 15.0 RAC1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.036 0.065 -9999.0 0.0 -0.126 67.0 67.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.023 0.049 -9999.0 0.0 -0.106 64.0 64.0 mol:GDP 0.001 0.1 -9999.0 0.0 -0.261 54.0 54.0 CDC42/GTP/IQGAP1 0.018 0.043 -9999.0 0.0 -0.116 50.0 50.0 JUP 0.019 0.021 -9999.0 0.0 -0.122 12.0 12.0 p120 catenin/RhoA/GDP 0.017 0.094 -9999.0 0.0 -0.233 53.0 53.0 RAC1/GTP/IQGAP1 0.017 0.044 -9999.0 0.0 -0.122 48.0 48.0 PIP5K1C/AP1M1 0.033 0.014 -9999.0 0.0 -0.079 9.0 9.0 RHOA 0.023 0.006 -9999.0 0.0 -0.122 1.0 1.0 CDC42 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.022 0.01 -9999.0 0.0 -0.122 2.0 2.0 positive regulation of S phase of mitotic cell cycle -0.014 0.063 -9999.0 0.0 -0.123 112.0 112.0 NME1 0.015 0.03 -9999.0 0.0 -0.122 24.0 24.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.011 0.138 -9999.0 0.0 -0.416 51.0 51.0 regulation of cell-cell adhesion -0.018 0.05 -9999.0 0.0 -0.179 34.0 34.0 WASF2 -0.002 0.036 -9999.0 0.0 -0.079 66.0 66.0 Rap1/GTP 0.013 0.08 -9999.0 0.0 -0.228 34.0 34.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.041 0.064 -9999.0 0.0 -0.105 76.0 76.0 CCND1 -0.018 0.076 -9999.0 0.0 -0.15 112.0 112.0 VAV2 -0.019 0.174 -9999.0 0.0 -0.529 47.0 47.0 RAP1/GDP 0.016 0.087 -9999.0 0.0 -0.239 37.0 37.0 adherens junction assembly -0.01 0.133 -9999.0 0.0 -0.402 51.0 51.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.009 -9999.0 0.0 -0.122 2.0 2.0 PIP5K1C 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.033 0.064 -9999.0 0.0 -0.174 23.0 23.0 E-cadherin/beta catenin 0.008 0.056 -9999.0 0.0 -0.226 28.0 28.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.008 0.13 -9999.0 0.0 -0.399 49.0 49.0 PIK3CA 0.02 0.017 -9999.0 0.0 -0.122 7.0 7.0 Rac1/GTP -0.059 0.113 -9999.0 0.0 -0.318 66.0 66.0 E-cadherin/beta catenin/alpha catenin 0.026 0.058 -9999.0 0.0 -0.128 64.0 64.0 ITGAE 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.011 0.137 -9999.0 0.0 -0.423 49.0 49.0