E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.04 0.146 -9999.0 0.0 -0.336 97.0 97.0 KLHL20 -0.015 0.1 0.2 13.0 -0.229 51.0 64.0 CYFIP2 0.038 0.011 -9999.0 0.0 0.0 45.0 45.0 Rac1/GDP -0.012 0.107 0.243 8.0 -0.251 48.0 56.0 ENAH -0.038 0.144 -9999.0 0.0 -0.334 95.0 95.0 AP1M1 0.036 0.015 -9999.0 0.0 0.0 78.0 78.0 RAP1B 0.038 0.013 -9999.0 0.0 0.0 57.0 57.0 RAP1A 0.039 0.01 -9999.0 0.0 0.0 35.0 35.0 CTNNB1 0.039 0.01 -9999.0 0.0 0.0 32.0 32.0 CDC42/GTP 0.002 0.08 0.158 4.0 -0.197 34.0 38.0 ABI1/Sra1/Nap1 -0.032 0.053 -9999.0 0.0 -0.156 60.0 60.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.068 0.068 -9999.0 0.0 -0.111 44.0 44.0 RAPGEF1 -0.037 0.13 0.28 3.0 -0.307 84.0 87.0 CTNND1 0.041 0.007 -9999.0 0.0 0.0 17.0 17.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.155 -9999.0 0.0 -0.336 101.0 101.0 CRK -0.034 0.137 0.214 4.0 -0.324 86.0 90.0 E-cadherin/gamma catenin/alpha catenin 0.05 0.065 -9999.0 0.0 -0.136 42.0 42.0 alphaE/beta7 Integrin 0.05 0.038 -9999.0 0.0 -0.134 17.0 17.0 IQGAP1 0.037 0.014 -9999.0 0.0 0.0 67.0 67.0 NCKAP1 0.039 0.01 -9999.0 0.0 0.0 33.0 33.0 Rap1/GTP/I-afadin 0.042 0.065 -9999.0 0.0 -0.112 64.0 64.0 DLG1 -0.044 0.15 -9999.0 0.0 -0.339 102.0 102.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.034 0.048 -9999.0 0.0 -0.149 53.0 53.0 MLLT4 0.033 0.017 -9999.0 0.0 0.0 110.0 110.0 ARF6/GTP/NME1/Tiam1 0.046 0.062 -9999.0 0.0 -0.109 57.0 57.0 PI3K -0.04 0.063 -9999.0 0.0 -0.191 53.0 53.0 ARF6 0.04 0.007 -9999.0 0.0 0.0 18.0 18.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.038 0.052 -9999.0 0.0 -0.149 30.0 30.0 TIAM1 0.037 0.014 -9999.0 0.0 0.0 70.0 70.0 E-cadherin(dimer)/Ca2+ 0.063 0.072 -9999.0 0.0 -0.127 51.0 51.0 AKT1 -0.008 0.062 0.149 18.0 -0.158 18.0 36.0 PIK3R1 0.034 0.016 -9999.0 0.0 0.0 106.0 106.0 CDH1 0.035 0.016 -9999.0 0.0 0.0 96.0 96.0 RhoA/GDP -0.013 0.107 0.22 5.0 -0.251 50.0 55.0 actin cytoskeleton organization -0.009 0.076 0.163 14.0 -0.167 50.0 64.0 CDC42/GDP -0.012 0.107 0.247 7.0 -0.253 48.0 55.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.002 0.073 -9999.0 0.0 -0.193 55.0 55.0 ITGB7 0.039 0.011 -9999.0 0.0 0.0 39.0 39.0 RAC1 0.039 0.01 -9999.0 0.0 0.0 35.0 35.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.068 0.078 -9999.0 0.0 -0.136 51.0 51.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.046 0.056 -9999.0 0.0 -0.108 48.0 48.0 mol:GDP -0.031 0.111 0.242 7.0 -0.284 50.0 57.0 CDC42/GTP/IQGAP1 0.04 0.046 -9999.0 0.0 -0.114 40.0 40.0 JUP 0.037 0.014 -9999.0 0.0 0.0 67.0 67.0 p120 catenin/RhoA/GDP -0.001 0.115 0.234 4.0 -0.257 50.0 54.0 RAC1/GTP/IQGAP1 0.038 0.046 -9999.0 0.0 -0.113 40.0 40.0 PIP5K1C/AP1M1 0.048 0.027 -9999.0 0.0 -0.136 1.0 1.0 RHOA 0.041 0.007 -9999.0 0.0 0.0 14.0 14.0 CDC42 0.04 0.008 -9999.0 0.0 0.0 22.0 22.0 CTNNA1 0.039 0.01 -9999.0 0.0 0.0 36.0 36.0 positive regulation of S phase of mitotic cell cycle -0.015 0.059 0.125 4.0 -0.123 93.0 97.0 NME1 0.035 0.015 -9999.0 0.0 0.0 87.0 87.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.039 0.147 -9999.0 0.0 -0.343 93.0 93.0 regulation of cell-cell adhesion -0.009 0.065 -9999.0 0.0 -0.153 53.0 53.0 WASF2 -0.006 0.042 0.098 12.0 -0.093 44.0 56.0 Rap1/GTP 0.001 0.087 0.203 9.0 -0.238 26.0 35.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.072 0.082 -9999.0 0.0 -0.122 49.0 49.0 CCND1 -0.019 0.071 0.143 4.0 -0.149 93.0 97.0 VAV2 -0.047 0.211 -9999.0 0.0 -0.619 45.0 45.0 RAP1/GDP -0.0 0.098 0.233 8.0 -0.259 29.0 37.0 adherens junction assembly -0.039 0.143 -9999.0 0.0 -0.334 93.0 93.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.04 0.009 -9999.0 0.0 0.0 28.0 28.0 PIP5K1C 0.037 0.013 -9999.0 0.0 0.0 63.0 63.0 regulation of heterotypic cell-cell adhesion 0.046 0.076 0.219 6.0 -0.126 58.0 64.0 E-cadherin/beta catenin 0.007 0.04 0.146 1.0 -0.227 12.0 13.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.038 0.142 -9999.0 0.0 -0.332 94.0 94.0 PIK3CA 0.03 0.019 -9999.0 0.0 0.0 150.0 150.0 Rac1/GTP -0.054 0.13 -9999.0 0.0 -0.35 63.0 63.0 E-cadherin/beta catenin/alpha catenin 0.052 0.065 -9999.0 0.0 -0.13 48.0 48.0 ITGAE 0.039 0.01 -9999.0 0.0 0.0 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.031 0.158 -9999.0 0.0 -0.343 101.0 101.0