Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.049 0.045 0.149 18.0 -9999.0 0.0 18.0 KIRREL 0.041 0.017 0.082 2.0 -0.037 2.0 4.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.049 0.045 -9999.0 0.0 -0.149 18.0 18.0 PLCG1 0.039 0.011 -9999.0 0.0 0.0 39.0 39.0 ARRB2 0.039 0.01 -9999.0 0.0 0.0 37.0 37.0 WASL 0.04 0.008 -9999.0 0.0 0.0 23.0 23.0 Nephrin/NEPH1/podocin/CD2AP 0.073 0.071 0.211 1.0 -0.117 39.0 40.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.031 0.057 -9999.0 0.0 -0.143 30.0 30.0 FYN 0.002 0.063 0.17 56.0 -0.127 17.0 73.0 mol:Ca2+ 0.076 0.063 0.203 1.0 -0.128 24.0 25.0 mol:DAG 0.077 0.064 0.207 1.0 -0.129 24.0 25.0 NPHS2 0.042 0.02 0.081 2.0 -0.043 19.0 21.0 mol:IP3 0.077 0.064 0.207 1.0 -0.129 24.0 25.0 regulation of endocytosis 0.054 0.058 -9999.0 0.0 -0.12 20.0 20.0 Nephrin/NEPH1/podocin/Cholesterol 0.063 0.048 0.171 3.0 -0.111 18.0 21.0 establishment of cell polarity 0.049 0.045 -9999.0 0.0 -0.149 18.0 18.0 Nephrin/NEPH1/podocin/NCK1-2 0.085 0.078 -9999.0 0.0 -0.111 37.0 37.0 Nephrin/NEPH1/beta Arrestin2 0.057 0.06 -9999.0 0.0 -0.121 20.0 20.0 NPHS1 0.04 0.022 0.085 8.0 -0.044 17.0 25.0 Nephrin/NEPH1/podocin 0.055 0.056 0.218 1.0 -0.124 19.0 20.0 TJP1 0.037 0.013 -9999.0 0.0 0.0 65.0 65.0 NCK1 0.036 0.014 -9999.0 0.0 0.0 77.0 77.0 NCK2 0.041 0.006 -9999.0 0.0 0.0 10.0 10.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.079 0.065 0.211 1.0 -0.129 24.0 25.0 CD2AP 0.037 0.013 -9999.0 0.0 0.0 63.0 63.0 Nephrin/NEPH1/podocin/GRB2 0.085 0.058 0.211 1.0 -0.119 18.0 19.0 GRB2 0.041 0.007 -9999.0 0.0 0.0 14.0 14.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.005 0.071 0.173 68.0 -0.123 3.0 71.0 cytoskeleton organization 0.013 0.053 0.283 3.0 -0.16 12.0 15.0 Nephrin/NEPH1 0.042 0.034 -9999.0 0.0 -0.096 18.0 18.0 Nephrin/NEPH1/ZO-1 0.054 0.062 -9999.0 0.0 -0.131 36.0 36.0