Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.003 0.07 -9999.0 0.0 -0.191 52.0 52.0 epithelial cell differentiation 0.056 0.068 -9999.0 0.0 -0.126 51.0 51.0 CYFIP2 0.038 0.011 -9999.0 0.0 0.0 45.0 45.0 ENAH -0.034 0.072 0.211 14.0 -0.205 7.0 21.0 EGFR 0.036 0.014 -9999.0 0.0 0.0 73.0 73.0 EPHA2 0.039 0.01 -9999.0 0.0 0.0 34.0 34.0 MYO6 -0.03 0.048 0.181 8.0 -0.207 17.0 25.0 CTNNB1 0.039 0.01 -9999.0 0.0 0.0 32.0 32.0 ABI1/Sra1/Nap1 0.061 0.058 -9999.0 0.0 -0.125 39.0 39.0 AQP5 -0.076 0.139 0.166 6.0 -0.362 99.0 105.0 CTNND1 0.041 0.007 -9999.0 0.0 0.0 17.0 17.0 mol:PI-4-5-P2 -0.03 0.044 0.179 7.0 -0.198 12.0 19.0 regulation of calcium-dependent cell-cell adhesion -0.028 0.045 0.186 8.0 -0.198 12.0 20.0 EGF 0.038 0.012 -9999.0 0.0 0.0 52.0 52.0 NCKAP1 0.039 0.01 -9999.0 0.0 0.0 33.0 33.0 AQP3 -0.023 0.057 0.177 3.0 -0.291 14.0 17.0 cortical microtubule organization 0.056 0.068 -9999.0 0.0 -0.126 51.0 51.0 GO:0000145 -0.029 0.04 0.159 7.0 -0.189 12.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.063 0.072 -9999.0 0.0 -0.127 51.0 51.0 MLLT4 0.033 0.017 -9999.0 0.0 0.0 110.0 110.0 ARF6/GDP -0.051 0.048 -9999.0 0.0 -0.195 26.0 26.0 ARF6 0.04 0.007 -9999.0 0.0 0.0 18.0 18.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.077 -9999.0 0.0 -0.122 61.0 61.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.016 0.05 0.212 6.0 -0.196 18.0 24.0 PVRL2 0.039 0.011 -9999.0 0.0 0.0 43.0 43.0 ZYX -0.027 0.042 0.189 7.0 -0.204 8.0 15.0 ARF6/GTP 0.067 0.083 -9999.0 0.0 -0.122 62.0 62.0 CDH1 0.035 0.016 -9999.0 0.0 0.0 96.0 96.0 EGFR/EGFR/EGF/EGF 0.037 0.075 -9999.0 0.0 -0.125 73.0 73.0 RhoA/GDP 0.056 0.072 -9999.0 0.0 -0.124 54.0 54.0 actin cytoskeleton organization -0.032 0.049 0.16 7.0 -0.227 17.0 24.0 IGF-1R heterotetramer 0.033 0.017 -9999.0 0.0 0.0 116.0 116.0 GIT1 0.04 0.008 -9999.0 0.0 0.0 23.0 23.0 IGF1R 0.033 0.017 -9999.0 0.0 0.0 116.0 116.0 IGF1 0.036 0.015 -9999.0 0.0 0.0 82.0 82.0 DIAPH1 -0.002 0.221 -9999.0 0.0 -0.559 70.0 70.0 Wnt receptor signaling pathway -0.056 0.068 0.126 51.0 -9999.0 0.0 51.0 RHOA 0.041 0.007 -9999.0 0.0 0.0 14.0 14.0 RhoA/GTP -0.051 0.047 -9999.0 0.0 -0.188 27.0 27.0 CTNNA1 0.039 0.01 -9999.0 0.0 0.0 36.0 36.0 VCL -0.033 0.05 0.161 7.0 -0.231 17.0 24.0 EFNA1 0.034 0.016 -9999.0 0.0 0.0 101.0 101.0 LPP -0.029 0.044 0.175 7.0 -0.195 14.0 21.0 Ephrin A1/EPHA2 0.032 0.077 -9999.0 0.0 -0.126 75.0 75.0 SEC6/SEC8 -0.045 0.043 -9999.0 0.0 -0.15 42.0 42.0 MGAT3 -0.029 0.046 0.187 8.0 -0.201 12.0 20.0 HGF/MET 0.016 0.087 -9999.0 0.0 -0.125 124.0 124.0 HGF 0.04 0.009 -9999.0 0.0 0.0 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.003 0.07 -9999.0 0.0 -0.192 52.0 52.0 actin cable formation 0.002 0.098 0.245 31.0 -0.23 21.0 52.0 KIAA1543 -0.033 0.043 0.165 7.0 -0.2 13.0 20.0 KIFC3 -0.032 0.042 0.179 6.0 -0.201 12.0 18.0 NCK1 0.036 0.014 -9999.0 0.0 0.0 77.0 77.0 EXOC3 0.041 0.005 -9999.0 0.0 0.0 7.0 7.0 ACTN1 -0.031 0.05 0.186 9.0 -0.213 16.0 25.0 NCK1/GIT1 0.044 0.047 -9999.0 0.0 -0.135 30.0 30.0 mol:GDP 0.056 0.068 -9999.0 0.0 -0.126 51.0 51.0 EXOC4 0.038 0.012 -9999.0 0.0 0.0 51.0 51.0 STX4 -0.029 0.034 0.035 8.0 -0.12 51.0 59.0 PIP5K1C -0.03 0.044 0.181 7.0 -0.201 12.0 19.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.04 0.009 -9999.0 0.0 0.0 28.0 28.0 ROCK1 -0.027 0.086 0.234 17.0 -0.226 6.0 23.0 adherens junction assembly -0.053 0.135 -9999.0 0.0 -0.435 40.0 40.0 IGF-1R heterotetramer/IGF1 0.024 0.082 -9999.0 0.0 -0.13 87.0 87.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.05 -9999.0 0.0 -0.139 31.0 31.0 MET 0.027 0.02 -9999.0 0.0 0.0 195.0 195.0 PLEKHA7 -0.031 0.046 0.181 8.0 -0.203 14.0 22.0 mol:GTP 0.059 0.075 -9999.0 0.0 -0.122 61.0 61.0 establishment of epithelial cell apical/basal polarity -0.037 0.056 0.134 27.0 -0.204 15.0 42.0 cortical actin cytoskeleton stabilization 0.003 0.07 -9999.0 0.0 -0.191 52.0 52.0 regulation of cell-cell adhesion -0.032 0.049 0.16 7.0 -0.227 17.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.003 0.07 -9999.0 0.0 -0.192 52.0 52.0