Uterine Corpus Endometrioid Carcinoma: Correlation between gene mutation status and selected clinical features
Maintained by TCGA GDAC Team (Broad Institute/Dana-Farber Cancer Institute/Harvard Medical School)
Overview
Introduction

This pipeline computes the correlation between significantly recurrent gene mutations and selected clinical features.

Summary

Testing the association between mutation status of 283 genes and 5 clinical features across 248 patients, 8 significant findings detected with Q value < 0.25.

  • PTEN mutation correlated to 'HISTOLOGICAL.TYPE'.

  • TP53 mutation correlated to 'HISTOLOGICAL.TYPE'.

  • KRAS mutation correlated to 'AGE'.

  • LRCH2 mutation correlated to 'HISTOLOGICAL.TYPE'.

  • BRS3 mutation correlated to 'HISTOLOGICAL.TYPE'.

  • NEFM mutation correlated to 'HISTOLOGICAL.TYPE'.

  • SIGLEC8 mutation correlated to 'HISTOLOGICAL.TYPE'.

  • COX7B mutation correlated to 'Time to Death'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between mutation status of 283 genes and 5 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 8 significant findings detected.

Clinical
Features 		Time
to
Death 		AGE HISTOLOGICAL
TYPE 		RADIATIONS
RADIATION
REGIMENINDICATION 		NEOADJUVANT
THERAPY
nMutated (%) nWild-Type logrank test t-test Chi-square test Fisher's exact test Fisher's exact test
PTEN 141 (57%) 107 0.246
(1.00) 		0.0141
(1.00) 		2.6e-14
(3.67e-11) 		0.177
(1.00) 		0.0148
(1.00)
TP53 46 (19%) 202 0.369
(1.00) 		0.000734
(1.00) 		2.48e-15
(3.51e-12) 		0.731
(1.00) 		0.00326
(1.00)
KRAS 27 (11%) 221 0.116
(1.00) 		3.28e-05
(0.0463) 		0.117
(1.00) 		0.672
(1.00) 		0.0116
(1.00)
LRCH2 17 (7%) 231 0.655
(1.00) 		0.0283
(1.00) 		0.000157
(0.222) 		1
(1.00) 		0.415
(1.00)
BRS3 13 (5%) 235 0.222
(1.00) 		0.426
(1.00) 		2.47e-05
(0.0349) 		0.142
(1.00) 		0.524
(1.00)
NEFM 14 (6%) 234 0.295
(1.00) 		0.171
(1.00) 		9.77e-05
(0.138) 		0.0204
(1.00) 		0.218
(1.00)
SIGLEC8 12 (5%) 236 0.843
(1.00) 		0.773
(1.00) 		0.000128
(0.181) 		1
(1.00) 		0.741
(1.00)
COX7B 3 (1%) 245 5.16e-05
(0.0728) 		0.687
(1.00) 		0.765
(1.00) 		1
(1.00) 		0.564
(1.00)
CTCF 40 (16%) 208 0.563
(1.00) 		0.0108
(1.00) 		0.0205
(1.00) 		0.717
(1.00) 		1
(1.00)
PIK3CA 114 (46%) 134 0.0372
(1.00) 		0.329
(1.00) 		0.222
(1.00) 		0.424
(1.00) 		0.776
(1.00)
PIK3R1 77 (31%) 171 0.999
(1.00) 		0.704
(1.00) 		0.000284
(0.4) 		0.248
(1.00) 		0.222
(1.00)
ARID1A 77 (31%) 171 0.0142
(1.00) 		0.00511
(1.00) 		0.00361
(1.00) 		0.472
(1.00) 		0.0138
(1.00)
CTNNB1 61 (25%) 187 0.897
(1.00) 		0.0045
(1.00) 		0.00026
(0.366) 		0.438
(1.00) 		0.0126
(1.00)
FBXW7 26 (10%) 222 0.168
(1.00) 		0.926
(1.00) 		0.176
(1.00) 		0.275
(1.00) 		0.244
(1.00)
FGFR2 25 (10%) 223 0.729
(1.00) 		0.783
(1.00) 		0.289
(1.00) 		0.828
(1.00) 		0.815
(1.00)
PPP2R1A 27 (11%) 221 0.121
(1.00) 		0.0374
(1.00) 		0.00478
(1.00) 		0.52
(1.00) 		0.112
(1.00)
ARID5B 26 (10%) 222 0.333
(1.00) 		0.368
(1.00) 		0.128
(1.00) 		1
(1.00) 		0.816
(1.00)
SPOP 18 (7%) 230 0.753
(1.00) 		0.464
(1.00) 		0.682
(1.00) 		1
(1.00) 		0.413
(1.00)
CCND1 12 (5%) 236 0.238
(1.00) 		0.142
(1.00) 		0.594
(1.00) 		0.552
(1.00) 		0.741
(1.00)
MUC5B 39 (16%) 209 0.0956
(1.00) 		0.892
(1.00) 		0.0164
(1.00) 		0.271
(1.00) 		0.848
(1.00)
ZFHX3 41 (17%) 207 0.376
(1.00) 		0.709
(1.00) 		0.0156
(1.00) 		0.722
(1.00) 		0.254
(1.00)
SMTNL2 9 (4%) 239 0.472
(1.00) 		0.53
(1.00) 		0.524
(1.00) 		1
(1.00) 		0.451
(1.00)
MLL4 28 (11%) 220 0.116
(1.00) 		0.246
(1.00) 		0.135
(1.00) 		0.836
(1.00) 		0.118
(1.00)
BCOR 29 (12%) 219 0.115
(1.00) 		0.0278
(1.00) 		0.104
(1.00) 		0.836
(1.00) 		0.119
(1.00)
TNFAIP6 12 (5%) 236 0.819
(1.00) 		0.302
(1.00) 		0.124
(1.00) 		1
(1.00) 		0.741
(1.00)
GIGYF2 21 (8%) 227 0.766
(1.00) 		0.14
(1.00) 		0.0296
(1.00) 		0.00773
(1.00) 		0.452
(1.00)
CSMD3 37 (15%) 211 0.784
(1.00) 		0.329
(1.00) 		0.141
(1.00) 		0.853
(1.00) 		0.237
(1.00)
RBMX 13 (5%) 235 0.336
(1.00) 		0.161
(1.00) 		0.00678
(1.00) 		0.142
(1.00) 		0.756
(1.00)
FOXA2 9 (4%) 239 0.745
(1.00) 		0.396
(1.00) 		0.845
(1.00) 		0.722
(1.00) 		0.709
(1.00)
NFASC 24 (10%) 224 0.392
(1.00) 		0.579
(1.00) 		0.452
(1.00) 		1
(1.00) 		1
(1.00)
RASA1 18 (7%) 230 0.224
(1.00) 		0.64
(1.00) 		0.638
(1.00) 		0.616
(1.00) 		0.786
(1.00)
ETV3 9 (4%) 239 0.524
(1.00) 		0.404
(1.00) 		0.429
(1.00) 		0.497
(1.00) 		1
(1.00)
FAM9A 10 (4%) 238 0.44
(1.00) 		0.754
(1.00) 		0.855
(1.00) 		1
(1.00) 		0.293
(1.00)
NRAS 8 (3%) 240 0.393
(1.00) 		0.799
(1.00) 		0.815
(1.00) 		0.719
(1.00) 		0.452
(1.00)
LOC642587 7 (3%) 241 0.679
(1.00) 		0.548
(1.00) 		0.159
(1.00) 		1
(1.00) 		0.677
(1.00)
NFE2L2 12 (5%) 236 0.935
(1.00) 		0.397
(1.00) 		0.312
(1.00) 		1
(1.00) 		1
(1.00)
RB1 18 (7%) 230 0.596
(1.00) 		0.144
(1.00) 		0.0185
(1.00) 		0.313
(1.00) 		0.786
(1.00)
ESR1 10 (4%) 238 0.332
(1.00) 		0.441
(1.00) 		0.49
(1.00) 		0.318
(1.00) 		0.143
(1.00)
CHD4 23 (9%) 225 0.784
(1.00) 		0.817
(1.00) 		0.249
(1.00) 		0.819
(1.00) 		0.629
(1.00)
DNER 16 (6%) 232 0.915
(1.00) 		0.0211
(1.00) 		0.00818
(1.00) 		0.182
(1.00) 		0.388
(1.00)
ELFN2 11 (4%) 237 0.378
(1.00) 		0.776
(1.00) 		0.0106
(1.00) 		0.518
(1.00) 		0.298
(1.00)
KCNQ2 9 (4%) 239 0.358
(1.00) 		0.254
(1.00) 		0.266
(1.00) 		0.281
(1.00) 		1
(1.00)
RNPC3 5 (2%) 243 0.16
(1.00) 		0.47
(1.00) 		0.823
(1.00) 		1
(1.00) 		0.617
(1.00)
BCL6B 9 (4%) 239 0.487
(1.00) 		0.59
(1.00) 		0.356
(1.00) 		0.497
(1.00) 		1
(1.00)
CYLC1 15 (6%) 233 0.317
(1.00) 		0.729
(1.00) 		0.117
(1.00) 		0.0955
(1.00) 		0.766
(1.00)
KCND2 17 (7%) 231 0.909
(1.00) 		0.149
(1.00) 		0.0204
(1.00) 		0.432
(1.00) 		1
(1.00)
INPP4A 14 (6%) 234 0.24
(1.00) 		0.438
(1.00) 		0.0536
(1.00) 		0.777
(1.00) 		0.362
(1.00)
PPFIA2 19 (8%) 229 0.239
(1.00) 		0.458
(1.00) 		0.025
(1.00) 		0.805
(1.00) 		0.604
(1.00)
SIN3A 18 (7%) 230 0.702
(1.00) 		0.0914
(1.00) 		0.000598
(0.84) 		0.44
(1.00) 		0.587
(1.00)
CDH10 19 (8%) 229 0.168
(1.00) 		0.133
(1.00) 		0.0746
(1.00) 		1
(1.00) 		0.604
(1.00)
NCAM2 18 (7%) 230 0.188
(1.00) 		0.253
(1.00) 		0.155
(1.00) 		0.313
(1.00) 		0.786
(1.00)
RPL14 6 (2%) 242 0.571
(1.00) 		0.714
(1.00) 		0.702
(1.00) 		0.0971
(1.00) 		0.667
(1.00)
LCORL 10 (4%) 238 0.368
(1.00) 		0.14
(1.00) 		0.257
(1.00) 		1
(1.00) 		0.293
(1.00)
PASD1 17 (7%) 231 0.188
(1.00) 		0.756
(1.00) 		0.438
(1.00) 		0.599
(1.00) 		0.573
(1.00)
CNPY1 7 (3%) 241 0.449
(1.00) 		0.18
(1.00) 		0.55
(1.00) 		1
(1.00) 		0.677
(1.00)
ATP11C 18 (7%) 230 0.603
(1.00) 		0.237
(1.00) 		0.0688
(1.00) 		0.313
(1.00) 		0.786
(1.00)
MUC4 23 (9%) 225 0.294
(1.00) 		0.305
(1.00) 		0.0878
(1.00) 		1
(1.00) 		0.629
(1.00)
EPHA5 17 (7%) 231 0.218
(1.00) 		0.155
(1.00) 		0.108
(1.00) 		0.292
(1.00) 		0.166
(1.00)
IRX1 10 (4%) 238 0.5
(1.00) 		0.341
(1.00) 		0.0039
(1.00) 		0.318
(1.00) 		0.732
(1.00)
PXDN 21 (8%) 227 0.722
(1.00) 		0.771
(1.00) 		0.0181
(1.00) 		0.811
(1.00) 		1
(1.00)
C5ORF38 6 (2%) 242 0.682
(1.00) 		0.873
(1.00) 		0.0719
(1.00) 		0.415
(1.00) 		1
(1.00)
SGK1 10 (4%) 238 0.647
(1.00) 		0.145
(1.00) 		0.204
(1.00) 		0.0345
(1.00) 		1
(1.00)
FAM47A 15 (6%) 233 0.951
(1.00) 		0.333
(1.00) 		0.125
(1.00) 		0.78
(1.00) 		0.563
(1.00)
ANKRD30A 22 (9%) 226 0.486
(1.00) 		0.638
(1.00) 		0.374
(1.00) 		0.639
(1.00) 		0.453
(1.00)
RASSF2 10 (4%) 238 0.449
(1.00) 		0.0327
(1.00) 		0.261
(1.00) 		0.739
(1.00) 		1
(1.00)
NOL4 19 (8%) 229 0.591
(1.00) 		0.218
(1.00) 		0.0452
(1.00) 		0.616
(1.00) 		0.604
(1.00)
SSX5 10 (4%) 238 0.33
(1.00) 		0.108
(1.00) 		0.00338
(1.00) 		1
(1.00) 		0.732
(1.00)
MRPS30 9 (4%) 239 0.655
(1.00) 		0.74
(1.00) 		0.12
(1.00) 		0.497
(1.00) 		0.709
(1.00)
PCDHA9 13 (5%) 235 0.959
(1.00) 		0.195
(1.00) 		0.0027
(1.00) 		0.142
(1.00) 		0.197
(1.00)
SSTR1 9 (4%) 239 0.318
(1.00) 		0.568
(1.00) 		0.429
(1.00) 		0.722
(1.00) 		1
(1.00)
OR10J3 9 (4%) 239 0.618
(1.00) 		0.331
(1.00) 		0.133
(1.00) 		1
(1.00) 		0.263
(1.00)
DSC3 10 (4%) 238 0.872
(1.00) 		0.542
(1.00) 		0.171
(1.00) 		1
(1.00) 		0.293
(1.00)
PGR 10 (4%) 238 0.298
(1.00) 		0.207
(1.00) 		0.342
(1.00) 		0.739
(1.00) 		0.732
(1.00)
RYR2 36 (15%) 212 0.853
(1.00) 		0.951
(1.00) 		0.0703
(1.00) 		0.256
(1.00) 		0.227
(1.00)
COLEC11 8 (3%) 240 0.708
(1.00) 		0.665
(1.00) 		0.0691
(1.00) 		0.127
(1.00) 		0.688
(1.00)
FATE1 6 (2%) 242 0.607
(1.00) 		0.961
(1.00) 		0.00573
(1.00) 		0.415
(1.00) 		0.667
(1.00)
HELT 7 (3%) 241 0.44
(1.00) 		0.58
(1.00) 		0.192
(1.00) 		0.236
(1.00) 		0.677
(1.00)
MKI67 29 (12%) 219 0.306
(1.00) 		0.607
(1.00) 		0.00204
(1.00) 		0.836
(1.00) 		0.119
(1.00)
OR4K2 10 (4%) 238 0.306
(1.00) 		0.328
(1.00) 		0.0268
(1.00) 		0.739
(1.00) 		0.468
(1.00)
PCDHA12 18 (7%) 230 0.83
(1.00) 		0.078
(1.00) 		0.0106
(1.00) 		1
(1.00) 		1
(1.00)
PDZD4 7 (3%) 241 0.491
(1.00) 		0.731
(1.00) 		0.0368
(1.00) 		1
(1.00) 		1
(1.00)
SLCO4A1 10 (4%) 238 0.504
(1.00) 		0.287
(1.00) 		0.072
(1.00) 		1
(1.00) 		0.732
(1.00)
SI 22 (9%) 226 0.457
(1.00) 		0.444
(1.00) 		0.521
(1.00) 		0.346
(1.00) 		0.453
(1.00)
KLK6 8 (3%) 240 0.458
(1.00) 		0.5
(1.00) 		0.641
(1.00) 		1
(1.00) 		1
(1.00)
LSR 7 (3%) 241 0.000747
(1.00) 		0.0556
(1.00) 		0.106
(1.00) 		0.0485
(1.00) 		0.396
(1.00)
DCC 21 (8%) 227 0.776
(1.00) 		0.0961
(1.00) 		0.101
(1.00) 		0.229
(1.00) 		1
(1.00)
FAM161A 15 (6%) 233 0.179
(1.00) 		0.832
(1.00) 		0.113
(1.00) 		0.275
(1.00) 		0.369
(1.00)
JPH3 8 (3%) 240 0.376
(1.00) 		0.59
(1.00) 		0.0434
(1.00) 		0.127
(1.00) 		0.22
(1.00)
L1TD1 14 (6%) 234 0.307
(1.00) 		0.269
(1.00) 		0.266
(1.00) 		0.148
(1.00) 		0.764
(1.00)
RBBP6 20 (8%) 228 0.702
(1.00) 		0.921
(1.00) 		0.00311
(1.00) 		1
(1.00) 		0.113
(1.00)
OR4A15 11 (4%) 237 0.294
(1.00) 		0.118
(1.00) 		0.287
(1.00) 		0.753
(1.00) 		0.499
(1.00)
C9 14 (6%) 234 0.259
(1.00) 		0.069
(1.00) 		0.00936
(1.00) 		1
(1.00) 		0.764
(1.00)
CDH4 13 (5%) 235 0.178
(1.00) 		0.0384
(1.00) 		0.384
(1.00) 		0.769
(1.00) 		0.0223
(1.00)
FAM98B 9 (4%) 239 0.497
(1.00) 		0.169
(1.00) 		0.0372
(1.00) 		1
(1.00) 		1
(1.00)
HIST1H2BD 5 (2%) 243 0.0789
(1.00) 		0.876
(1.00) 		0.287
(1.00) 		0.342
(1.00) 		1
(1.00)
C1ORF212 4 (2%) 244 0.54
(1.00) 		0.0113
(1.00) 		0.612
(1.00) 		1
(1.00) 		0.0639
(1.00)
LZTR1 12 (5%) 236 0.371
(1.00) 		0.981
(1.00) 		0.0185
(1.00) 		0.349
(1.00) 		0.188
(1.00)
PAPD4 12 (5%) 236 0.879
(1.00) 		0.141
(1.00) 		0.0132
(1.00) 		0.349
(1.00) 		0.021
(1.00)
PCGF3 7 (3%) 241 0.272
(1.00) 		0.291
(1.00) 		0.223
(1.00) 		0.0485
(1.00) 		0.677
(1.00)
SESN3 12 (5%) 236 0.294
(1.00) 		0.655
(1.00) 		0.0208
(1.00) 		0.552
(1.00) 		0.52
(1.00)
CNTN6 18 (7%) 230 0.202
(1.00) 		0.607
(1.00) 		0.0147
(1.00) 		1
(1.00) 		1
(1.00)
MBOAT7 8 (3%) 240 0.496
(1.00) 		0.619
(1.00) 		0.842
(1.00) 		1
(1.00) 		0.452
(1.00)
MUTED 7 (3%) 241 0.378
(1.00) 		0.963
(1.00) 		0.192
(1.00) 		1
(1.00) 		1
(1.00)
ACSM3 14 (6%) 234 0.227
(1.00) 		0.126
(1.00) 		0.426
(1.00) 		0.777
(1.00) 		0.764
(1.00)
CNTNAP5 20 (8%) 228 0.615
(1.00) 		0.893
(1.00) 		0.219
(1.00) 		1
(1.00) 		0.796
(1.00)
KIAA0664 10 (4%) 238 0.582
(1.00) 		0.0249
(1.00) 		0.0422
(1.00) 		0.318
(1.00) 		0.732
(1.00)
PCDHA8 14 (6%) 234 0.285
(1.00) 		0.0589
(1.00) 		0.544
(1.00) 		0.248
(1.00) 		0.764
(1.00)
FAM65B 14 (6%) 234 0.252
(1.00) 		0.0417
(1.00) 		0.01
(1.00) 		1
(1.00) 		1
(1.00)
PCDH15 27 (11%) 221 0.371
(1.00) 		0.698
(1.00) 		0.0276
(1.00) 		1
(1.00) 		1
(1.00)
CDK17 11 (4%) 237 0.907
(1.00) 		0.155
(1.00) 		0.333
(1.00) 		0.753
(1.00) 		1
(1.00)
SLC7A5 5 (2%) 243 0.522
(1.00) 		0.51
(1.00) 		0.17
(1.00) 		0.342
(1.00) 		0.327
(1.00)
ATP6V1C2 10 (4%) 238 0.319
(1.00) 		0.0783
(1.00) 		0.0874
(1.00) 		1
(1.00) 		0.732
(1.00)
VKORC1L1 5 (2%) 243 0.562
(1.00) 		0.737
(1.00) 		0.823
(1.00) 		1
(1.00) 		1
(1.00)
ALS2CR11 15 (6%) 233 0.282
(1.00) 		0.703
(1.00) 		0.0994
(1.00) 		0.275
(1.00) 		0.766
(1.00)
SSTR4 9 (4%) 239 0.506
(1.00) 		0.479
(1.00) 		0.0204
(1.00) 		0.497
(1.00) 		0.451
(1.00)
PITX2 8 (3%) 240 0.418
(1.00) 		0.762
(1.00) 		0.319
(1.00) 		0.451
(1.00) 		0.452
(1.00)
ZNF334 16 (6%) 232 0.95
(1.00) 		0.035
(1.00) 		0.445
(1.00) 		0.79
(1.00) 		0.568
(1.00)
AGBL4 9 (4%) 239 0.198
(1.00) 		0.109
(1.00) 		0.182
(1.00) 		0.171
(1.00) 		0.709
(1.00)
FAM9B 7 (3%) 241 0.401
(1.00) 		0.512
(1.00) 		0.56
(1.00) 		0.236
(1.00) 		0.677
(1.00)
GNG4 5 (2%) 243 0.552
(1.00) 		0.879
(1.00) 		0.632
(1.00) 		0.168
(1.00) 		0.327
(1.00)
TCP11L2 12 (5%) 236 0.229
(1.00) 		0.906
(1.00) 		0.312
(1.00) 		1
(1.00) 		0.52
(1.00)
COL5A1 18 (7%) 230 0.88
(1.00) 		0.543
(1.00) 		0.0717
(1.00) 		0.797
(1.00) 		0.277
(1.00)
ZNF267 13 (5%) 235 0.759
(1.00) 		0.576
(1.00) 		0.057
(1.00) 		1
(1.00) 		1
(1.00)
KCNA6 12 (5%) 236 0.311
(1.00) 		0.0116
(1.00) 		0.12
(1.00) 		0.0253
(1.00) 		0.188
(1.00)
DCAF12L2 10 (4%) 238 0.27
(1.00) 		0.35
(1.00) 		0.204
(1.00) 		1
(1.00) 		0.732
(1.00)
MPRIP 11 (4%) 237 0.453
(1.00) 		0.507
(1.00) 		0.199
(1.00) 		0.518
(1.00) 		0.298
(1.00)
NFE2L3 11 (4%) 237 0.338
(1.00) 		0.736
(1.00) 		0.0107
(1.00) 		0.194
(1.00) 		1
(1.00)
FERD3L 6 (2%) 242 0.411
(1.00) 		0.659
(1.00) 		0.299
(1.00) 		0.667
(1.00) 		0.193
(1.00)
KCNA5 12 (5%) 236 0.715
(1.00) 		0.143
(1.00) 		0.344
(1.00) 		0.552
(1.00) 		1
(1.00)
SYCP1 14 (6%) 234 0.262
(1.00) 		0.432
(1.00) 		0.0111
(1.00) 		0.565
(1.00) 		0.764
(1.00)
ABCB1 19 (8%) 229 0.24
(1.00) 		0.442
(1.00) 		0.174
(1.00) 		1
(1.00) 		1
(1.00)
HOXA7 7 (3%) 241 0.487
(1.00) 		0.43
(1.00) 		0.159
(1.00) 		0.236
(1.00) 		0.677
(1.00)
TAB3 13 (5%) 235 0.311
(1.00) 		0.00569
(1.00) 		0.173
(1.00) 		1
(1.00) 		0.352
(1.00)
UPF3B 13 (5%) 235 0.867
(1.00) 		0.843
(1.00) 		0.683
(1.00) 		1
(1.00) 		0.121
(1.00)
BRD3 9 (4%) 239 0.897
(1.00) 		0.452
(1.00) 		0.524
(1.00) 		0.722
(1.00) 		0.451
(1.00)
HCN1 17 (7%) 231 0.774
(1.00) 		0.198
(1.00) 		0.0149
(1.00) 		1
(1.00) 		1
(1.00)
EPHA10 12 (5%) 236 0.296
(1.00) 		0.864
(1.00) 		0.0322
(1.00) 		0.552
(1.00) 		1
(1.00)
NAA25 16 (6%) 232 0.339
(1.00) 		0.0781
(1.00) 		0.437
(1.00) 		1
(1.00) 		0.568
(1.00)
ZBTB33 14 (6%) 234 0.337
(1.00) 		0.202
(1.00) 		0.305
(1.00) 		0.777
(1.00) 		0.764
(1.00)
ADAM23 14 (6%) 234 0.266
(1.00) 		0.42
(1.00) 		0.0136
(1.00) 		0.565
(1.00) 		0.764
(1.00)
CHL1 19 (8%) 229 0.0547
(1.00) 		0.128
(1.00) 		0.0565
(1.00) 		1
(1.00) 		0.604
(1.00)
ZNF275 8 (3%) 240 0.624
(1.00) 		0.463
(1.00) 		0.0528
(1.00) 		1
(1.00) 		0.452
(1.00)
COX19 4 (2%) 244 0.652
(1.00) 		0.269
(1.00) 		0.679
(1.00) 		1
(1.00) 		0.303
(1.00)
MORC4 14 (6%) 234 0.219
(1.00) 		0.114
(1.00) 		0.202
(1.00) 		0.248
(1.00) 		0.362
(1.00)
INPPL1 14 (6%) 234 0.829
(1.00) 		0.379
(1.00) 		0.09
(1.00) 		1
(1.00) 		1
(1.00)
THBS2 14 (6%) 234 0.294
(1.00) 		0.275
(1.00) 		0.099
(1.00) 		0.777
(1.00) 		1
(1.00)
ACSL4 14 (6%) 234 0.996
(1.00) 		0.174
(1.00) 		0.0367
(1.00) 		0.392
(1.00) 		0.362
(1.00)
BRCC3 8 (3%) 240 0.716
(1.00) 		0.559
(1.00) 		0.201
(1.00) 		0.719
(1.00) 		0.452
(1.00)
CDKN1B 6 (2%) 242 0.423
(1.00) 		0.17
(1.00) 		0.77
(1.00) 		1
(1.00) 		0.193
(1.00)
UBE2E3 6 (2%) 242 0.642
(1.00) 		0.355
(1.00) 		0.0886
(1.00) 		0.415
(1.00) 		1
(1.00)
FAM47B 16 (6%) 232 0.99
(1.00) 		0.0123
(1.00) 		0.007
(1.00) 		0.423
(1.00) 		0.568
(1.00)
FMN2 16 (6%) 232 0.997
(1.00) 		0.589
(1.00) 		0.00824
(1.00) 		0.423
(1.00) 		0.773
(1.00)
MCTP1 12 (5%) 236 0.335
(1.00) 		0.0453
(1.00) 		0.182
(1.00) 		0.349
(1.00) 		0.319
(1.00)
CASP8 11 (4%) 237 0.709
(1.00) 		0.406
(1.00) 		0.0362
(1.00) 		0.753
(1.00) 		0.732
(1.00)
WHSC2 6 (2%) 242 0.339
(1.00) 		0.211
(1.00) 		0.969
(1.00) 		0.415
(1.00) 		0.193
(1.00)
MNDA 9 (4%) 239 0.667
(1.00) 		0.204
(1.00) 		0.732
(1.00) 		0.171
(1.00) 		1
(1.00)
STAG2 18 (7%) 230 0.244
(1.00) 		0.439
(1.00) 		0.419
(1.00) 		0.313
(1.00) 		1
(1.00)
WDR45 9 (4%) 239 0.358
(1.00) 		0.63
(1.00) 		0.000996
(1.00) 		0.281
(1.00) 		1
(1.00)
ACVR1 9 (4%) 239 0.393
(1.00) 		0.442
(1.00) 		0.429
(1.00) 		0.281
(1.00) 		0.451
(1.00)
CCDC104 10 (4%) 238 0.327
(1.00) 		0.0526
(1.00) 		0.022
(1.00) 		0.501
(1.00) 		0.732
(1.00)
HIST1H2AM 4 (2%) 244 0.534
(1.00) 		0.847
(1.00) 		0.485
(1.00) 		0.302
(1.00) 		0.577
(1.00)
LEPREL2 9 (4%) 239 0.0428
(1.00) 		0.0574
(1.00) 		0.000988
(1.00) 		1
(1.00) 		0.709
(1.00)
ADAMTS19 16 (6%) 232 0.957
(1.00) 		0.283
(1.00) 		0.0463
(1.00) 		1
(1.00) 		0.773
(1.00)
ANKMY1 13 (5%) 235 0.888
(1.00) 		0.294
(1.00) 		0.0565
(1.00) 		1
(1.00) 		0.756
(1.00)
PCDHA4 15 (6%) 233 0.358
(1.00) 		0.99
(1.00) 		0.3
(1.00) 		1
(1.00) 		1
(1.00)
KIAA1967 12 (5%) 236 0.628
(1.00) 		0.546
(1.00) 		0.0879
(1.00) 		0.552
(1.00) 		0.52
(1.00)
RUNX1 8 (3%) 240 0.446
(1.00) 		0.163
(1.00) 		0.163
(1.00) 		0.719
(1.00) 		1
(1.00)
TRIM59 9 (4%) 239 0.315
(1.00) 		0.949
(1.00) 		0.356
(1.00) 		1
(1.00) 		0.451
(1.00)
CD1C 9 (4%) 239 0.432
(1.00) 		0.907
(1.00) 		0.732
(1.00) 		0.722
(1.00) 		0.451
(1.00)
POU4F1 6 (2%) 242 0.556
(1.00) 		0.497
(1.00) 		0.0886
(1.00) 		1
(1.00) 		1
(1.00)
TSC2 11 (4%) 237 0.39
(1.00) 		0.546
(1.00) 		0.22
(1.00) 		1
(1.00) 		0.732
(1.00)
BCL2L11 5 (2%) 243 0.812
(1.00) 		0.985
(1.00) 		0.823
(1.00) 		0.168
(1.00) 		0.327
(1.00)
MARCH11 8 (3%) 240 0.39
(1.00) 		0.238
(1.00) 		0.579
(1.00) 		0.451
(1.00) 		1
(1.00)
IGFBP7 5 (2%) 243 0.517
(1.00) 		0.567
(1.00) 		0.617
(1.00) 		0.663
(1.00) 		1
(1.00)
FBXO31 6 (2%) 242 0.418
(1.00) 		0.955
(1.00) 		0.368
(1.00) 		0.185
(1.00) 		1
(1.00)
OR5AS1 8 (3%) 240 0.455
(1.00) 		0.73
(1.00) 		0.214
(1.00) 		0.719
(1.00) 		0.111
(1.00)
PON1 11 (4%) 237 0.303
(1.00) 		0.0454
(1.00) 		0.367
(1.00) 		0.753
(1.00) 		1
(1.00)
ITGB2 10 (4%) 238 0.582
(1.00) 		0.428
(1.00) 		0.367
(1.00) 		0.739
(1.00) 		0.293
(1.00)
GALNT13 13 (5%) 235 0.294
(1.00) 		0.407
(1.00) 		0.000521
(0.732) 		0.769
(1.00) 		1
(1.00)
TRPM2 13 (5%) 235 0.897
(1.00) 		0.319
(1.00) 		0.0012
(1.00) 		0.769
(1.00) 		0.756
(1.00)
GFOD1 7 (3%) 241 0.587
(1.00) 		0.569
(1.00) 		0.959
(1.00) 		1
(1.00) 		0.677
(1.00)
DCLK1 14 (6%) 234 0.228
(1.00) 		0.046
(1.00) 		0.121
(1.00) 		0.565
(1.00) 		1
(1.00)
TMC4 8 (3%) 240 0.38
(1.00) 		0.625
(1.00) 		0.699
(1.00) 		0.451
(1.00) 		1
(1.00)
ZC3H18 12 (5%) 236 0.237
(1.00) 		0.97
(1.00) 		0.647
(1.00) 		0.552
(1.00) 		0.52
(1.00)
TAF1 25 (10%) 223 0.442
(1.00) 		0.89
(1.00) 		0.0107
(1.00) 		0.514
(1.00) 		0.346
(1.00)
FLNA 22 (9%) 226 0.698
(1.00) 		0.847
(1.00) 		0.0423
(1.00) 		0.0572
(1.00) 		0.325
(1.00)
BMP7 9 (4%) 239 0.321
(1.00) 		0.599
(1.00) 		0.266
(1.00) 		1
(1.00) 		0.119
(1.00)
DSG1 11 (4%) 237 0.288
(1.00) 		0.67
(1.00) 		0.0397
(1.00) 		1
(1.00) 		0.732
(1.00)
HPD 7 (3%) 241 0.43
(1.00) 		0.0538
(1.00) 		0.55
(1.00) 		1
(1.00) 		1
(1.00)
KCNE2 6 (2%) 242 0.641
(1.00) 		0.171
(1.00) 		0.0886
(1.00) 		0.415
(1.00) 		1
(1.00)
LIMCH1 14 (6%) 234 0.993
(1.00) 		0.571
(1.00) 		0.0488
(1.00) 		1
(1.00) 		1
(1.00)
MAP7D2 16 (6%) 232 0.237
(1.00) 		0.0182
(1.00) 		0.0389
(1.00) 		0.79
(1.00) 		1
(1.00)
SATB1 12 (5%) 236 0.27
(1.00) 		0.422
(1.00) 		0.397
(1.00) 		1
(1.00) 		0.52
(1.00)
SHOX2 7 (3%) 241 0.391
(1.00) 		0.428
(1.00) 		0.21
(1.00) 		0.694
(1.00) 		0.677
(1.00)
TPTE2 12 (5%) 236 0.299
(1.00) 		0.822
(1.00) 		0.023
(1.00) 		1
(1.00) 		0.741
(1.00)
CIRBP 4 (2%) 244 0.641
(1.00) 		0.726
(1.00) 		0.282
(1.00) 		0.0132
(1.00) 		1
(1.00)
DCAF8L1 11 (4%) 237 0.308
(1.00) 		0.0727
(1.00) 		0.000692
(0.97) 		1
(1.00) 		0.499
(1.00)
DLGAP2 11 (4%) 237 0.977
(1.00) 		0.76
(1.00) 		0.185
(1.00) 		1
(1.00) 		0.732
(1.00)
GK 12 (5%) 236 0.269
(1.00) 		0.903
(1.00) 		0.000413
(0.581) 		0.0253
(1.00) 		1
(1.00)
GK2 15 (6%) 233 0.276
(1.00) 		0.277
(1.00) 		0.16
(1.00) 		0.0955
(1.00) 		0.766
(1.00)
NAP1L5 3 (1%) 245 0.881
(1.00) 		0.743
(1.00) 		0.851
(1.00) 		0.271
(1.00) 		1
(1.00)
SAFB 10 (4%) 238 0.3
(1.00) 		0.433
(1.00) 		0.445
(1.00) 		1
(1.00) 		0.732
(1.00)
FOXP2 13 (5%) 235 0.402
(1.00) 		0.747
(1.00) 		0.0896
(1.00) 		0.551
(1.00) 		0.524
(1.00)
GYPB 4 (2%) 244 0.589
(1.00) 		0.817
(1.00) 		0.864
(1.00) 		0.302
(1.00) 		1
(1.00)
KLK7 4 (2%) 244 0.506
(1.00) 		0.389
(1.00) 		0.95
(1.00) 		0.118
(1.00) 		1
(1.00)
SDK2 18 (7%) 230 0.224
(1.00) 		0.982
(1.00) 		0.0382
(1.00) 		0.0689
(1.00) 		0.587
(1.00)
SSX3 7 (3%) 241 0.391
(1.00) 		0.499
(1.00) 		0.55
(1.00) 		1
(1.00) 		1
(1.00)
MTPAP 12 (5%) 236 0.294
(1.00) 		0.257
(1.00) 		0.235
(1.00) 		0.229
(1.00) 		0.52
(1.00)
KHDRBS2 8 (3%) 240 0.4
(1.00) 		0.176
(1.00) 		0.0577
(1.00) 		0.719
(1.00) 		0.688
(1.00)
CACNA1E 25 (10%) 223 0.433
(1.00) 		0.835
(1.00) 		0.0168
(1.00) 		0.514
(1.00) 		0.482
(1.00)
TRIM67 11 (4%) 237 0.378
(1.00) 		0.684
(1.00) 		0.0488
(1.00) 		0.518
(1.00) 		1
(1.00)
GRIA3 16 (6%) 232 0.759
(1.00) 		0.405
(1.00) 		0.0306
(1.00) 		0.423
(1.00) 		0.0775
(1.00)
ATP6V1B1 10 (4%) 238 0.38
(1.00) 		0.719
(1.00) 		0.342
(1.00) 		1
(1.00) 		0.732
(1.00)
SMARCA1 14 (6%) 234 0.282
(1.00) 		0.892
(1.00) 		0.352
(1.00) 		0.148
(1.00) 		0.121
(1.00)
SOCS2 6 (2%) 242 0.529
(1.00) 		0.155
(1.00) 		0.445
(1.00) 		0.667
(1.00) 		0.667
(1.00)
BTNL8 7 (3%) 241 0.453
(1.00) 		0.773
(1.00) 		0.613
(1.00) 		0.694
(1.00) 		1
(1.00)
ADARB2 7 (3%) 241 0.609
(1.00) 		0.59
(1.00) 		0.613
(1.00) 		0.236
(1.00) 		1
(1.00)
CYLC2 9 (4%) 239 0.875
(1.00) 		0.97
(1.00) 		0.5
(1.00) 		0.722
(1.00) 		0.263
(1.00)
ZNF648 9 (4%) 239 0.357
(1.00) 		0.513
(1.00) 		0.317
(1.00) 		0.281
(1.00) 		1
(1.00)
POU4F2 7 (3%) 241 0.462
(1.00) 		0.643
(1.00) 		0.623
(1.00) 		1
(1.00) 		0.677
(1.00)
CCDC75 5 (2%) 243 0.474
(1.00) 		0.367
(1.00) 		0.412
(1.00) 		0.663
(1.00) 		1
(1.00)
MED12 21 (8%) 227 0.207
(1.00) 		0.0181
(1.00) 		0.0996
(1.00) 		0.811
(1.00) 		0.803
(1.00)
HIST1H1E 4 (2%) 244 0.512
(1.00) 		0.354
(1.00) 		0.679
(1.00) 		0.118
(1.00) 		0.0639
(1.00)
PHRF1 10 (4%) 238 0.748
(1.00) 		0.134
(1.00) 		0.0438
(1.00) 		0.318
(1.00) 		0.468
(1.00)
CDH19 15 (6%) 233 0.231
(1.00) 		0.0434
(1.00) 		0.0399
(1.00) 		1
(1.00) 		1
(1.00)
GDF10 8 (3%) 240 0.32
(1.00) 		0.513
(1.00) 		0.641
(1.00) 		0.451
(1.00) 		0.452
(1.00)
INSC 10 (4%) 238 0.392
(1.00) 		0.546
(1.00) 		0.766
(1.00) 		1
(1.00) 		0.293
(1.00)
NKAP 9 (4%) 239 0.653
(1.00) 		0.314
(1.00) 		0.017
(1.00) 		0.497
(1.00) 		0.709
(1.00)
P2RY11 8 (3%) 240 0.47
(1.00) 		0.398
(1.00) 		0.272
(1.00) 		0.451
(1.00) 		0.688
(1.00)
HIST1H2AG 5 (2%) 243 0.647
(1.00) 		0.837
(1.00) 		0.788
(1.00) 		0.0483
(1.00) 		1
(1.00)
NDN 6 (2%) 242 0.535
(1.00) 		0.487
(1.00) 		0.975
(1.00) 		1
(1.00) 		0.667
(1.00)
BMP5 11 (4%) 237 0.224
(1.00) 		0.289
(1.00) 		0.208
(1.00) 		0.753
(1.00) 		0.732
(1.00)
FAT1 30 (12%) 218 0.122
(1.00) 		0.861
(1.00) 		0.0217
(1.00) 		1
(1.00) 		0.827
(1.00)
MTM1 12 (5%) 236 0.307
(1.00) 		0.773
(1.00) 		0.566
(1.00) 		0.756
(1.00) 		0.188
(1.00)
MYPN 19 (8%) 229 0.667
(1.00) 		0.403
(1.00) 		0.0015
(1.00) 		0.218
(1.00) 		0.294
(1.00)
NRXN1 18 (7%) 230 0.674
(1.00) 		0.587
(1.00) 		0.0219
(1.00) 		0.44
(1.00) 		0.413
(1.00)
MED15 10 (4%) 238 0.405
(1.00) 		0.41
(1.00) 		0.127
(1.00) 		0.739
(1.00) 		0.293
(1.00)
ARHGAP36 12 (5%) 236 0.285
(1.00) 		0.252
(1.00) 		0.33
(1.00) 		1
(1.00) 		1
(1.00)
GABRA3 10 (4%) 238 0.334
(1.00) 		0.557
(1.00) 		0.19
(1.00) 		0.318
(1.00) 		0.732
(1.00)
CSDE1 15 (6%) 233 0.296
(1.00) 		0.192
(1.00) 		0.0664
(1.00) 		0.589
(1.00) 		0.369
(1.00)
WDR64 14 (6%) 234 0.277
(1.00) 		0.528
(1.00) 		0.35
(1.00) 		0.148
(1.00) 		0.764
(1.00)
PORCN 10 (4%) 238 0.382
(1.00) 		0.131
(1.00) 		0.364
(1.00) 		1
(1.00) 		0.732
(1.00)
FLJ43860 12 (5%) 236 0.589
(1.00) 		0.159
(1.00) 		0.101
(1.00) 		0.115
(1.00) 		0.52
(1.00)
DIS3L2 12 (5%) 236 0.859
(1.00) 		0.0572
(1.00) 		0.0237
(1.00) 		0.552
(1.00) 		0.021
(1.00)
GPR142 11 (4%) 237 0.367
(1.00) 		0.204
(1.00) 		0.0653
(1.00) 		1
(1.00) 		1
(1.00)
MED24 12 (5%) 236 0.25
(1.00) 		0.167
(1.00) 		0.0973
(1.00) 		0.115
(1.00) 		0.52
(1.00)
TMEM132D 12 (5%) 236 0.269
(1.00) 		0.782
(1.00) 		0.892
(1.00) 		1
(1.00) 		0.741
(1.00)
RPL39 3 (1%) 245 0.538
(1.00) 		0.427
(1.00) 		0.851
(1.00) 		0.553
(1.00) 		1
(1.00)
ATF6 12 (5%) 236 0.275
(1.00) 		0.472
(1.00) 		0.0154
(1.00) 		0.552
(1.00) 		1
(1.00)
CPB1 8 (3%) 240 0.012
(1.00) 		0.687
(1.00) 		0.716
(1.00) 		0.719
(1.00) 		1
(1.00)
KRTAP19-8 3 (1%) 245 0.541
(1.00) 		0.563
(1.00) 		0.464
(1.00) 		0.271
(1.00) 		1
(1.00)
ATM 25 (10%) 223 0.136
(1.00) 		0.2
(1.00) 		0.0321
(1.00) 		1
(1.00) 		0.0189
(1.00)
CDC73 12 (5%) 236 0.25
(1.00) 		0.235
(1.00) 		0.0817
(1.00) 		1
(1.00) 		0.741
(1.00)
NPEPL1 6 (2%) 242 0.59
(1.00) 		0.713
(1.00) 		0.669
(1.00) 		1
(1.00) 		1
(1.00)
SLC16A2 10 (4%) 238 0.59
(1.00) 		0.846
(1.00) 		0.509
(1.00) 		0.501
(1.00) 		0.732
(1.00)
DMD 30 (12%) 218 0.51
(1.00) 		0.978
(1.00) 		0.687
(1.00) 		0.416
(1.00) 		0.668
(1.00)
OR5M11 7 (3%) 241 0.4
(1.00) 		0.729
(1.00) 		0.0585
(1.00) 		1
(1.00) 		1
(1.00)
AGAP2 12 (5%) 236 0.425
(1.00) 		0.493
(1.00) 		0.166
(1.00) 		0.756
(1.00) 		1
(1.00)
C16ORF45 5 (2%) 243 0.451
(1.00) 		0.355
(1.00) 		0.17
(1.00) 		1
(1.00) 		0.617
(1.00)
KCNH2 10 (4%) 238 0.432
(1.00) 		0.597
(1.00) 		0.109
(1.00) 		0.0959
(1.00) 		0.143
(1.00)
CPXM2 12 (5%) 236 0.344
(1.00) 		0.804
(1.00) 		0.0185
(1.00) 		0.552
(1.00) 		0.52
(1.00)
GPA33 9 (4%) 239 0.948
(1.00) 		0.214
(1.00) 		0.0146
(1.00) 		0.722
(1.00) 		0.709
(1.00)
CDH1 11 (4%) 237 0.951
(1.00) 		0.0392
(1.00) 		0.334
(1.00) 		0.753
(1.00) 		0.499
(1.00)
ENPP5 10 (4%) 238 0.386
(1.00) 		0.181
(1.00) 		0.445
(1.00) 		0.501
(1.00) 		1
(1.00)
LTF 10 (4%) 238 0.368
(1.00) 		0.618
(1.00) 		0.0127
(1.00) 		0.318
(1.00) 		0.732
(1.00)
MOGAT3 7 (3%) 241 0.437
(1.00) 		0.562
(1.00) 		0.223
(1.00) 		0.694
(1.00) 		0.092
(1.00)
NRG1 14 (6%) 234 0.281
(1.00) 		0.725
(1.00) 		0.0205
(1.00) 		0.565
(1.00) 		1
(1.00)
CHD3 22 (9%) 226 0.199
(1.00) 		0.638
(1.00) 		0.00487
(1.00) 		1
(1.00) 		0.208
(1.00)
OR5D13 8 (3%) 240 0.872
(1.00) 		0.845
(1.00) 		0.0732
(1.00) 		0.451
(1.00) 		0.688
(1.00)
PDLIM2 4 (2%) 244 0.702
(1.00) 		0.588
(1.00) 		0.612
(1.00) 		0.608
(1.00) 		1
(1.00)
SLC48A1 3 (1%) 245 0.691
(1.00) 		0.354
(1.00) 		0.353
(1.00) 		1
(1.00) 		1
(1.00)
STEAP4 10 (4%) 238 0.288
(1.00) 		0.533
(1.00) 		0.0755
(1.00) 		1
(1.00) 		0.732
(1.00)
BMF 3 (1%) 245 0.00143
(1.00) 		0.266
(1.00) 		0.597
(1.00) 		0.553
(1.00) 		1
(1.00)
ZC3H13 20 (8%) 228 0.152
(1.00) 		0.236
(1.00) 		0.00876
(1.00) 		0.329
(1.00) 		0.796
(1.00)
CFL2 6 (2%) 242 0.42
(1.00) 		0.194
(1.00) 		0.0719
(1.00) 		0.415
(1.00) 		1
(1.00)
RRAS2 4 (2%) 244 0.752
(1.00) 		0.0717
(1.00) 		0.864
(1.00) 		0.608
(1.00) 		0.0639
(1.00)
CDCA7L 9 (4%) 239 0.441
(1.00) 		0.0696
(1.00) 		0.726
(1.00) 		0.722
(1.00) 		0.119
(1.00)
KCMF1 9 (4%) 239 0.472
(1.00) 		0.617
(1.00) 		0.000996
(1.00) 		0.497
(1.00) 		1
(1.00)
THEG 6 (2%) 242 0.464
(1.00) 		0.154
(1.00) 		0.547
(1.00) 		0.415
(1.00) 		0.193
(1.00)
PIK3R3 8 (3%) 240 0.373
(1.00) 		0.523
(1.00) 		0.684
(1.00) 		0.27
(1.00) 		0.111
(1.00)
CAPS2 8 (3%) 240 0.38
(1.00) 		0.0342
(1.00) 		0.00547
(1.00) 		0.719
(1.00) 		1
(1.00)
LRFN2 13 (5%) 235 0.914
(1.00) 		0.831
(1.00) 		0.051
(1.00) 		0.378
(1.00) 		0.352
(1.00)
NSDHL 9 (4%) 239 0.435
(1.00) 		0.315
(1.00) 		0.0158
(1.00) 		0.281
(1.00) 		0.709
(1.00)
'PTEN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 2.6e-14 (Chi-square test), Q value = 3.7e-11

Table S1.  Gene #4: 'PTEN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID UTERINE SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 101 21 29 49 4 44
PTEN MUTATED 70 19 19 31 1 1
PTEN WILD-TYPE 31 2 10 18 3 43

Figure S1.  Get High-res Image Gene #4: 'PTEN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'TP53 MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 2.48e-15 (Chi-square test), Q value = 3.5e-12

Table S2.  Gene #5: 'TP53 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID UTERINE SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 101 21 29 49 4 44
TP53 MUTATED 4 1 1 11 2 27
TP53 WILD-TYPE 97 20 28 38 2 17

Figure S2.  Get High-res Image Gene #5: 'TP53 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'KRAS MUTATION STATUS' versus 'AGE'

P value = 3.28e-05 (t-test), Q value = 0.046

Table S3.  Gene #11: 'KRAS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 248 63.1 (11.1)
KRAS MUTATED 27 56.3 (7.5)
KRAS WILD-TYPE 221 63.9 (11.2)

Figure S3.  Get High-res Image Gene #11: 'KRAS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'LRCH2 MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 0.000157 (Chi-square test), Q value = 0.22

Table S4.  Gene #34: 'LRCH2 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID UTERINE SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 101 21 29 49 4 44
LRCH2 MUTATED 3 1 2 11 0 0
LRCH2 WILD-TYPE 98 20 27 38 4 44

Figure S4.  Get High-res Image Gene #34: 'LRCH2 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'BRS3 MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 2.47e-05 (Chi-square test), Q value = 0.035

Table S5.  Gene #52: 'BRS3 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID UTERINE SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 101 21 29 49 4 44
BRS3 MUTATED 2 0 1 10 0 0
BRS3 WILD-TYPE 99 21 28 39 4 44

Figure S5.  Get High-res Image Gene #52: 'BRS3 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'NEFM MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 9.77e-05 (Chi-square test), Q value = 0.14

Table S6.  Gene #108: 'NEFM MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID UTERINE SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 101 21 29 49 4 44
NEFM MUTATED 3 0 1 10 0 0
NEFM WILD-TYPE 98 21 28 39 4 44

Figure S6.  Get High-res Image Gene #108: 'NEFM MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'SIGLEC8 MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 0.000128 (Chi-square test), Q value = 0.18

Table S7.  Gene #136: 'SIGLEC8 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1 OR 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 1) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 2) ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA (GRADE 3) MIXED SEROUS AND ENDOMETRIOID UTERINE SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 101 21 29 49 4 44
SIGLEC8 MUTATED 2 1 0 9 0 0
SIGLEC8 WILD-TYPE 99 20 29 40 4 44

Figure S7.  Get High-res Image Gene #136: 'SIGLEC8 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'COX7B MUTATION STATUS' versus 'Time to Death'

P value = 5.16e-05 (logrank test), Q value = 0.073

Table S8.  Gene #187: 'COX7B MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 248 17 0.0 - 173.6 (22.2)
COX7B MUTATED 3 1 1.8 - 15.8 (11.9)
COX7B WILD-TYPE 245 16 0.0 - 173.6 (22.4)

Figure S8.  Get High-res Image Gene #187: 'COX7B MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'

Methods & Data
Input

  • Mutation data file = UCEC.mutsig.cluster.txt

  • Clinical data file = UCEC.clin.merged.picked.txt

  • Number of patients = 248

  • Number of significantly mutated genes = 283

  • Number of selected clinical features = 5

  • Exclude genes that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Student's t-test analysis

For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene mutations using 't.test' function in R

Chi-square test

For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

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References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)
[3] Greenwood and Nikulin, A guide to chi-squared testing, Wiley, New York. ISBN 047155779X (1996)
[4] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[5] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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