rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p q 1 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 70 CALM2(3), CALML6(3), CDS1(4), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKI(16), DGKZ(8), IMPA1(3), IMPA2(5), INPP1(2), INPP4A(16), INPP4B(12), INPP5A(4), INPP5B(4), INPP5D(9), INPPL1(14), ITPK1(2), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), OCRL(15), PI4KA(9), PI4KB(6), PIK3C2A(14), PIK3C2B(10), PIK3C2G(12), PIK3C3(9), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PIP4K2A(2), PIP4K2B(7), PIP4K2C(3), PIP5K1A(6), PIP5K1B(3), PIP5K1C(4), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(3), PLCD4(10), PLCE1(31), PLCG1(8), PLCG2(23), PLCZ1(11), PRKCA(7), PRKCG(6), PTEN(208), PTPMT1(1), SYNJ1(24), SYNJ2(8) 43792584 1019 212 833 215 215 262 191 47 215 89 <1.00e-15 <9.78e-15 2 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(5), ACTR3(1), AKT1(3), AKT2(4), AKT3(7), ANGPTL2(4), ARHGAP1(2), ARHGAP4(8), ARHGEF11(18), BTK(4), CDC42(4), CFL1(1), CFL2(7), GDI1(4), GDI2(1), INPPL1(14), ITPR1(23), ITPR2(25), ITPR3(15), LIMK1(6), MYLK(10), MYLK2(6), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PDK1(2), PIK3CA(142), PIK3CD(9), PIK3CG(18), PIK3R1(106), PITX2(9), PPP1R13B(5), PTEN(208), RACGAP1(7), RHO(3), ROCK1(15), ROCK2(10), RPS4X(1), SAG(4), WASF1(3), WASL(7) 25519200 746 209 565 117 155 155 137 32 178 89 <1.00e-15 <9.78e-15 3 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(3), EIF4A1(4), EIF4A2(4), EIF4B(5), EIF4E(2), EIF4G1(10), EIF4G2(6), EIF4G3(18), MKNK1(3), PDK2(3), PDPK1(2), PIK3CA(142), PIK3R1(106), PPP2CA(4), PTEN(208), RPS6(6), RPS6KB1(2), TSC1(9), TSC2(13) 9352328 550 208 375 33 88 81 114 25 157 85 <1.00e-15 <9.78e-15 4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(3), AKT2(4), AKT3(7), BRD4(7), CAP1(7), CBL(8), CDC42(4), CDKN2A(1), F2RL2(2), FLOT2(1), GRB2(3), GSK3A(8), GSK3B(8), IGFBP1(4), INPPL1(14), IRS1(10), IRS4(16), LNPEP(6), MAPK1(2), MAPK3(3), PARD3(19), PDK1(2), PIK3CA(142), PIK3CD(9), PIK3R1(106), PPYR1(6), PTEN(208), PTPN1(4), RAF1(5), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KB1(2), SERPINB6(2), SHC1(5), SLC2A4(5), SORBS1(14), SOS1(10), SOS2(16), YWHAE(2), YWHAG(3), YWHAH(2), YWHAQ(1), YWHAZ(1) 20890280 712 208 527 94 136 135 150 29 175 87 <1.00e-15 <9.78e-15 5 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(3), EIF4A1(4), EIF4A2(4), EIF4E(2), EIF4G1(10), EIF4G2(6), EIF4G3(18), GHR(8), IRS1(10), MAPK1(2), MAPK14(4), MAPK3(3), MKNK1(3), PABPC1(8), PDK2(3), PDPK1(2), PIK3CA(142), PIK3R1(106), PRKCA(7), PTEN(208), RPS6KB1(2) 10285800 555 206 380 37 85 76 123 28 158 85 <1.00e-15 <9.78e-15 6 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(9), AKT1(3), AKT2(4), AKT3(7), APAF1(11), ATM(42), BAD(2), BAX(3), BCL2L1(3), BID(2), BIRC2(10), BIRC3(2), CAPN1(2), CAPN2(5), CASP10(8), CASP3(3), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CFLAR(5), CHUK(7), CSF2RB(9), CYCS(2), DFFB(3), FAS(6), FASLG(5), IKBKB(8), IL1B(2), IL1R1(4), IL1RAP(5), IL3RA(8), IRAK1(4), IRAK2(5), IRAK3(7), IRAK4(5), MAP3K14(4), MYD88(1), NFKB1(7), NFKB2(9), NFKBIA(2), NTRK1(11), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKACA(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RELA(4), RIPK1(8), TNFRSF10A(2), TNFRSF10B(4), TNFRSF10C(2), TNFRSF10D(5), TNFRSF1A(4), TP53(48), TRAF2(2) 29073536 679 206 554 120 151 194 109 39 145 41 <1.00e-15 <9.78e-15 7 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(3), EIF2B5(4), EIF2S2(5), EIF2S3(5), EIF4E(2), GSK3B(8), IGF1(2), IGF1R(10), INPPL1(14), PDK2(3), PDPK1(2), PIK3CA(142), PIK3R1(106), PPP2CA(4), PTEN(208), RPS6(6), RPS6KB1(2) 7229448 526 206 350 35 83 68 111 21 158 85 <1.00e-15 <9.78e-15 8 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 ACTA1(3), CRK(1), CRKL(4), DOCK1(17), ELK1(2), FOS(2), GAB1(5), GRB2(3), HGF(13), ITGA1(13), ITGB1(5), JUN(1), MAP2K1(2), MAP4K1(9), MAPK1(2), MAPK3(3), MAPK8(7), MET(9), PAK1(1), PIK3CA(142), PIK3R1(106), PTEN(208), PTK2(8), PTK2B(13), PTPN11(5), PXN(4), RAF1(5), RAP1A(3), RAP1B(2), RASA1(23), SOS1(10), SRC(2), STAT3(8) 16040640 641 205 462 67 116 112 130 27 171 85 <1.00e-15 <9.78e-15 9 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(3), CDKN1B(6), GRB2(3), ILK(4), ITGB1(5), MAPK1(2), MAPK3(3), PDK2(3), PDPK1(2), PIK3CA(142), PIK3R1(106), PTEN(208), PTK2(8), SHC1(5), SOS1(10) 6596056 510 203 333 25 74 64 114 22 151 85 <1.00e-15 <9.78e-15 10 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 15 ABL1(5), CDKN2A(1), E2F1(6), MDM2(3), MYC(6), PIK3CA(142), PIK3R1(106), POLR1A(11), POLR1B(10), POLR1C(2), POLR1D(1), RAC1(1), RB1(23), TBX2(2), TP53(48) 7272352 367 198 251 40 83 72 66 25 80 41 <1.00e-15 <9.78e-15 11 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(2), AKT1(3), AKT2(4), AKT3(7), BAD(2), BTK(4), CDKN2A(1), DAPP1(7), GRB2(3), GSK3A(8), GSK3B(8), IARS(7), IGFBP1(4), INPP5D(9), PDK1(2), PIK3CA(142), PPP1R13B(5), PTEN(208), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KB1(2), SHC1(5), SOS1(10), SOS2(16), TEC(5), YWHAE(2), YWHAG(3), YWHAH(2), YWHAQ(1), YWHAZ(1) 13060672 503 198 342 50 104 98 116 23 112 50 <1.00e-15 <9.78e-15 12 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(3), AKT2(4), AKT3(7), BCR(4), BTK(4), CD19(3), CDKN2A(1), DAPP1(7), FLOT2(1), GAB1(5), ITPR1(23), ITPR2(25), ITPR3(15), LYN(6), NR0B2(2), PDK1(2), PHF11(3), PIK3CA(142), PITX2(9), PLCG2(23), PPP1R13B(5), PREX1(17), PTEN(208), PTPRC(11), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KB1(2), SAG(4), SYK(3), TEC(5), VAV1(10) 20136112 584 197 426 96 125 135 123 27 124 50 <1.00e-15 <9.78e-15 13 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 AKT1(3), APC(36), AXIN1(7), CCND1(12), CD14(2), CTNNB1(63), FZD1(3), GJA1(5), GNAI1(4), GSK3B(8), IRAK1(4), LBP(2), LEF1(8), LY96(3), MYD88(1), NFKB1(7), PDPK1(2), PIK3CA(142), PIK3R1(106), PPP2CA(4), RELA(4), TIRAP(2), TLR4(13), WNT1(1) 10269432 442 196 293 36 92 113 77 34 85 41 <1.00e-15 <9.78e-15 14 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 60 APAF1(11), ATM(42), ATR(26), BAI1(6), BAX(3), BID(2), CASP3(3), CASP8(12), CASP9(2), CCNB1(7), CCNB2(3), CCNB3(19), CCND1(12), CCND2(7), CCND3(3), CCNE2(5), CCNG1(6), CCNG2(2), CD82(2), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(11), CYCS(2), DDB2(3), EI24(3), FAS(6), GTSE1(1), IGF1(2), IGFBP3(3), MDM2(3), PERP(3), PMAIP1(1), PPM1D(9), PTEN(208), RCHY1(3), RFWD2(4), RRM2(5), RRM2B(4), SERPINE1(5), SESN1(4), SESN2(2), SESN3(13), SIAH1(3), STEAP3(4), THBS1(9), TNFRSF10B(4), TP53(48), TP53I3(4), TSC2(13), ZMAT3(8) 21514496 573 195 479 103 90 141 98 29 159 56 <1.00e-15 <9.78e-15 15 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 93 AKT1(3), AKT2(4), AKT3(7), CASP8(12), CCL4(1), CCL5(2), CD14(2), CD40(2), CD80(5), CD86(4), CHUK(7), CXCL10(2), CXCL9(2), FOS(2), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(6), IFNAR2(6), IFNB1(2), IKBKB(8), IKBKE(1), IL12A(5), IL12B(2), IL1B(2), IL6(4), IL8(3), IRAK1(4), IRAK4(5), IRF3(2), IRF5(5), JUN(1), LBP(2), LY96(3), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K7(8), MAP3K8(6), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK8(7), MAPK9(4), MYD88(1), NFKB1(7), NFKB2(9), NFKBIA(2), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), RAC1(1), RELA(4), RIPK1(8), SPP1(2), STAT1(12), TBK1(5), TICAM1(6), TICAM2(4), TIRAP(2), TLR1(10), TLR2(11), TLR3(5), TLR4(13), TLR5(6), TLR6(9), TLR7(12), TLR8(16), TLR9(5), TRAF3(4), TRAF6(3) 31180048 664 195 552 124 153 197 119 35 121 39 <1.00e-15 <9.78e-15 16 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(3), AKT2(4), AKT3(7), BPNT1(1), GRB2(3), ILK(4), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(142), PIK3CD(9), PTEN(208), PTK2B(13), RBL2(15), SHC1(5), SOS1(10) 7240112 431 194 271 30 84 73 103 20 100 51 <1.00e-15 <9.78e-15 17 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(3), AGT(7), AKT1(3), CALM2(3), CALR(1), CAMK1(2), CAMK1G(3), CAMK4(3), CREBBP(24), CSNK1A1(4), EDN1(2), ELSPBP1(4), F2(8), GATA4(1), GSK3B(8), HAND1(5), IGF1(2), LIF(2), MAP2K1(2), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(7), MEF2C(8), MYH2(31), NFATC2(9), NFATC3(9), NFATC4(7), NPPA(1), PIK3CA(142), PIK3R1(106), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RAF1(5), RPS6KB1(2), SYT1(4) 17612464 459 192 350 61 102 116 86 25 93 37 <1.00e-15 <9.78e-15 18 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 46 ACOX1(3), APOA2(1), CD36(5), CPT1B(1), CREBBP(24), DUSP1(2), EHHADH(4), EP300(23), FABP1(4), HSD17B4(8), JUN(1), LPL(9), MAPK1(2), MAPK3(3), ME1(7), MRPL11(1), MYC(6), NCOA1(15), NCOR1(16), NCOR2(16), NFKBIA(2), NR0B2(2), NR1H3(4), NR2F1(5), NRIP1(14), PIK3CA(142), PIK3R1(106), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PTGS2(6), RB1(23), RELA(4), RXRA(1), SP1(6), SRA1(1), STAT5A(2), STAT5B(3) 21371152 500 192 392 75 104 134 95 29 95 43 <1.00e-15 <9.78e-15 19 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(3), APC(36), AR(4), ASAH1(6), BRAF(9), CCL13(2), CCL15(1), CCL16(1), DAG1(4), EGFR(10), GNA11(2), GNA15(1), GNAI1(4), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), KCNJ3(9), KCNJ5(5), KCNJ9(4), MAPK1(2), MAPK10(7), MAPK14(4), PHKA2(12), PIK3CA(142), PIK3CD(9), PIK3R1(106), PITX2(9), PTX3(1), RAF1(5), SRC(2) 19109640 470 192 365 85 106 121 89 20 89 45 <1.00e-15 <9.78e-15 20 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 41 AKT1(3), AKT2(4), AKT3(7), BRAF(9), CAB39(6), DDIT4(2), EIF4B(5), FIGF(5), HIF1A(12), IGF1(2), MAPK1(2), MAPK3(3), PDPK1(2), PGF(1), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PRKAA1(5), PRKAA2(7), RHEB(2), RICTOR(20), RPS6(6), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA6(12), RPS6KB1(2), RPS6KB2(4), TSC1(9), TSC2(13), ULK2(7), ULK3(5), VEGFB(2), VEGFC(6) 17006352 500 191 390 69 121 125 90 30 97 37 <1.00e-15 <9.78e-15 21 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 37 AKT1(3), ASAH1(6), ATF1(4), BRAF(9), CREB1(5), CREB5(3), CREBBP(24), CRKL(4), DAG1(4), EGR1(6), EGR2(4), EGR3(5), ELK1(2), FRS2(4), JUN(1), MAP1B(27), MAP2K4(4), MAPK1(2), MAPK10(7), MAPK3(3), MAPK8(7), MAPK8IP1(4), MAPK9(4), NTRK1(11), OPN1LW(4), PIK3C2G(12), PIK3CA(142), PIK3CD(9), PIK3R1(106), PTPN11(5), RPS6KA3(15), SHC1(5), SRC(2), TERF2IP(2) 16678248 455 190 349 70 101 126 82 23 81 42 <1.00e-15 <9.78e-15 22 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(3), CCND1(12), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN1B(6), E2F1(6), MAPK1(2), MAPK3(3), NFKB1(7), NFKBIA(2), PAK1(1), PIK3CA(142), PIK3R1(106), RAC1(1), RAF1(5), RB1(23), RELA(4) 7277312 332 189 227 24 63 66 71 18 73 41 <1.00e-15 <9.78e-15 23 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(12), ARHGEF1(9), F2(8), F2R(6), GNA12(7), GNA13(7), GNAI1(4), GNB1(1), MAP3K7(8), PIK3CA(142), PIK3R1(106), PLCB1(4), PPP1R12B(11), PRKCA(7), PTK2B(13), ROCK1(15) 9135576 360 188 255 39 91 75 71 19 63 41 <1.00e-15 <9.78e-15 24 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM2(3), CD3D(3), CD3E(1), CD3G(1), ELK1(2), FOS(2), FYN(6), GRB2(3), JUN(1), LCK(3), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK3(3), MAPK8(7), NFATC2(9), NFATC3(9), NFATC4(7), NFKB1(7), NFKBIA(2), PIK3CA(142), PIK3R1(106), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKCA(7), PTPN7(4), RAC1(1), RAF1(5), RASA1(23), RELA(4), SHC1(5), SOS1(10), SYT1(4), VAV1(10), ZAP70(6) 17029912 445 188 336 52 106 97 81 27 95 39 <1.00e-15 <9.78e-15 25 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(3), CABIN1(11), CALM2(3), CAMK1(2), CAMK1G(3), HDAC5(10), IGF1(2), IGF1R(10), INSR(12), MAP2K6(6), MAPK14(4), MAPK7(11), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), MYOD1(3), NFATC2(9), PIK3CA(142), PIK3R1(106), PPP3CA(2), PPP3CB(5), PPP3CC(4), SYT1(4), YWHAH(2) 11733376 371 187 268 51 77 93 71 20 73 37 <1.00e-15 <9.78e-15 26 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(3), AKT2(4), AKT3(7), BAD(2), GRB2(3), GSK3A(8), GSK3B(8), IL4R(5), IRS1(10), JAK1(16), JAK3(5), MAP4K1(9), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(142), PIK3CD(9), PIK3R1(106), PPP1R13B(5), RAF1(5), SHC1(5), SOS1(10), SOS2(16), STAT6(5) 12682224 390 187 281 43 83 95 81 20 72 39 <1.00e-15 <9.78e-15 27 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(12), AKT1(3), BAD(2), BAX(3), BCL2L1(3), CSF2RB(9), IGF1(2), IGF1R(10), IL3RA(8), KIT(22), KITLG(2), PIK3CA(142), PIK3R1(106), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), YWHAH(2) 7605912 347 186 243 37 77 80 66 20 67 37 <1.00e-15 <9.78e-15 28 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(12), AKT1(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CREB1(5), GNAS(16), GRB2(3), MAPK1(2), MAPK14(4), MAPK3(3), PIK3CA(142), PIK3R1(106), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), RAC1(1), RPS6KA1(1), RPS6KA5(7), SOS1(10) 9949016 357 186 249 38 74 82 68 22 74 37 <1.00e-15 <9.78e-15 29 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(12), AKT1(3), ASAH1(6), GNAI1(4), GNB1(1), ITGAV(6), ITGB3(10), MAPK1(2), MAPK3(3), PDGFRA(19), PIK3CA(142), PIK3R1(106), PLCB1(4), PRKCA(7), PTK2(8), RAC1(1), SMPD1(10), SMPD2(4), SPHK1(2), SRC(2) 9720112 352 186 247 43 67 81 72 21 72 39 <1.00e-15 <9.78e-15 30 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CDK5(1), CDK5R1(2), CFL1(1), CHN1(2), LIMK1(6), MAP3K1(24), MYL2(1), MYLK(10), NCF2(4), PAK1(1), PDGFRA(19), PIK3CA(142), PIK3R1(106), PLD1(9), PPP1R12B(11), RAC1(1), RALBP1(4), RPS6KB1(2), TRIO(25), VAV1(10), WASF1(3) 12860784 384 186 276 46 88 83 69 22 81 41 <1.00e-15 <9.78e-15 31 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), CREB1(5), GRB2(3), MAPK1(2), MAPK3(3), MAPK7(11), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), NTRK1(11), PIK3CA(142), PIK3R1(106), PLCG1(8), RPS6KA1(1), SHC1(5) 6784536 317 185 213 26 67 70 62 17 64 37 <1.00e-15 <9.78e-15 32 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(3), CREB1(5), MAP2K1(2), MAP2K3(7), MAP2K6(6), MAP3K1(24), MAPK1(2), MAPK14(4), MAPK3(3), NFKB1(7), PIK3CA(142), PIK3R1(106), RB1(23), RELA(4), SP1(6) 7032288 344 185 239 21 67 69 73 22 70 43 <1.00e-15 <9.78e-15 33 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(3), BAD(2), BCL2L1(3), CBL(8), CFLAR(5), CRKL(4), E2F1(6), FOS(2), GRB2(3), IL2RA(2), IL2RB(1), IL2RG(11), IRS1(10), JAK1(16), JAK3(5), MAPK1(2), MAPK3(3), MYC(6), NMI(1), PIK3CA(142), PIK3R1(106), PPIA(1), RAF1(5), RPS6KB1(2), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3), SYK(3) 12924520 372 185 267 41 81 94 72 20 68 37 <1.00e-15 <9.78e-15 34 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), INSR(12), IRS1(10), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(7), PIK3CA(142), PIK3R1(106), PTPN11(5), RAF1(5), RASA1(23), SHC1(5), SLC2A4(5), SOS1(10), SRF(2) 9064400 352 185 245 28 79 77 68 19 72 37 <1.00e-15 <9.78e-15 35 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), JAK1(16), JUN(1), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK3(3), MAPK8(7), PDGFRA(19), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), RAF1(5), RASA1(23), SHC1(5), SOS1(10), SRF(2), STAT1(12), STAT3(8), STAT5A(2) 12553264 420 185 309 40 94 91 79 29 86 41 <1.00e-15 <9.78e-15 36 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), BAD(2), CASP9(2), CHUK(7), GH1(2), GHR(8), NFKB1(7), NFKBIA(2), PDPK1(2), PIK3CA(142), PIK3R1(106), PPP2CA(4), RELA(4), YWHAH(2) 5225112 293 184 190 11 60 53 64 17 62 37 <1.00e-15 <9.78e-15 37 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(18), DIAPH1(10), FYN(6), GSN(4), ITGA1(13), ITGB1(5), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(1), MYLK(10), PFN1(1), PIK3CA(142), PIK3R1(106), PTK2(8), PXN(4), RAF1(5), ROCK1(15), SHC1(5), SRC(2), TLN1(20) 13822280 382 184 279 32 89 88 72 19 73 41 <1.00e-15 <9.78e-15 38 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(7), EGF(17), EGFR(10), ELK1(2), FOS(2), GRB2(3), JAK1(16), JUN(1), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK3(3), MAPK8(7), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), RAF1(5), RASA1(23), SHC1(5), SOS1(10), SRF(2), STAT1(12), STAT3(8), STAT5A(2) 13610736 428 184 317 47 95 96 81 28 89 39 <1.00e-15 <9.78e-15 39 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 BTK(4), CALM2(3), ELK1(2), FCER1A(7), FCER1G(1), FOS(2), GRB2(3), JUN(1), LYN(6), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK1(2), MAPK3(3), MAPK8(7), NFATC2(9), NFATC3(9), NFATC4(7), PAK2(3), PIK3CA(142), PIK3R1(106), PLA2G4A(9), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), RAF1(5), SHC1(5), SOS1(10), SYK(3), SYT1(4), VAV1(10) 15068480 412 184 304 48 108 82 76 25 82 39 <1.00e-15 <9.78e-15 40 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCR(4), CRKL(4), FOS(2), GRB2(3), JAK2(14), JUN(1), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK3(3), MAPK8(7), MYC(6), PIK3CA(142), PIK3R1(106), RAF1(5), SOS1(10), STAT1(12), STAT5A(2), STAT5B(3) 9895944 357 184 250 28 80 72 70 22 70 43 <1.00e-15 <9.78e-15 41 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), IGF1(2), IGF1R(10), IRS1(10), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(7), PIK3CA(142), PIK3R1(106), PTPN11(5), RAF1(5), RASA1(23), SHC1(5), SOS1(10), SRF(2) 8891792 347 184 240 26 77 72 69 20 72 37 <1.00e-15 <9.78e-15 42 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(24), EP300(23), FYN(6), IL2RG(11), IL7(1), IL7R(7), JAK1(16), JAK3(5), LCK(3), NMI(1), PIK3CA(142), PIK3R1(106), PTK2B(13), STAT5A(2), STAT5B(3) 10000600 363 184 258 44 78 83 69 18 78 37 <1.00e-15 <9.78e-15 43 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), BAD(2), CHRNB1(2), CHRNG(2), MUSK(11), PIK3CA(142), PIK3R1(106), PTK2(8), PTK2B(13), RAPSN(1), SRC(2), TERT(3), YWHAH(2) 5636544 297 183 194 32 66 56 62 17 59 37 <1.00e-15 <9.78e-15 44 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(3), BAD(2), BCL2L1(3), CASP9(2), CDC42(4), CHUK(7), ELK1(2), H2AFX(1), MAP2K1(2), MAPK3(3), NFKB1(7), PIK3CA(142), PIK3R1(106), RAC1(1), RAF1(5), RALA(3), RALBP1(4), RALGDS(9), RELA(4), RHOA(3) 6754776 313 183 208 17 64 66 67 15 64 37 <1.00e-15 <9.78e-15 45 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 27 DUSP1(2), GORASP1(7), MAP2K4(4), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK8(7), MAPK8IP1(4), MAPK9(4), MAPKAPK5(4), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PIK3CA(142), PIK3CD(9), PIK3R1(106), SYT1(4), TRAF2(2), TRAF3(4), TRAF5(6), TRAF6(3) 10022672 351 183 247 32 73 84 66 17 72 39 <1.00e-15 <9.78e-15 46 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(5), AKT1(3), ANXA1(4), CALM2(3), GNAS(16), GNB1(1), NFKB1(7), NOS3(6), NPPA(1), NR3C1(11), PIK3CA(142), PIK3R1(106), RELA(4), SYT1(4) 6103280 313 182 208 17 70 62 64 14 66 37 <1.00e-15 <9.78e-15 47 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GH1(2), GHR(8), GRB2(3), INSR(12), IRS1(10), JAK2(14), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), RAF1(5), RPS6KA1(1), SHC1(5), SLC2A4(5), SOS1(10), SRF(2), STAT5A(2), STAT5B(3) 11804056 352 182 246 42 76 76 74 20 65 41 <1.00e-15 <9.78e-15 48 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), BAD(2), GRB2(3), IGF1R(10), IRS1(10), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(142), PIK3R1(106), RAF1(5), SHC1(5), SOS1(10), YWHAH(2) 6863896 305 182 200 24 62 62 66 17 61 37 <1.00e-15 <9.78e-15 49 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(3), CAT(3), GH1(2), GHR(8), IGF1(2), IGF1R(10), PIK3CA(142), PIK3R1(106), SHC1(5), SOD1(2), SOD2(3) 4733576 286 182 183 20 57 53 62 17 60 37 <1.00e-15 <9.78e-15 50 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), DPM2(2), GRB2(3), KLK2(2), NTRK1(11), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), SHC1(5), SOS1(10) 5679448 299 182 193 24 65 59 61 18 59 37 <1.00e-15 <9.78e-15 51 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(5), ACTR3(1), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), CDC42(4), PAK1(1), PDGFRA(19), PIK3CA(142), PIK3R1(106), RAC1(1), WASL(7) 4950824 296 181 192 11 62 55 61 15 64 39 <1.00e-15 <9.78e-15 52 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(7), FOS(2), GRB2(3), JAK2(14), JUN(1), MAP2K1(2), MAPK3(3), MPL(4), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), RAF1(5), RASA1(23), SHC1(5), SOS1(10), STAT1(12), STAT3(8), STAT5A(2), STAT5B(3), THPO(5) 10901088 372 181 263 38 82 80 75 21 73 41 <1.00e-15 <9.78e-15 53 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 CRK(1), CXCL12(2), CXCR4(1), GNAI1(4), GNB1(1), MAP2K1(2), MAPK1(2), MAPK3(3), NFKB1(7), PIK3C2G(12), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), PTK2(8), PTK2B(13), PXN(4), RAF1(5), RELA(4) 9670512 332 180 228 40 73 66 71 19 66 37 <1.00e-15 <9.78e-15 54 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(2), HLA-A(1), IL18(1), ITGB1(5), KLRC1(2), KLRC2(3), KLRC3(1), KLRC4(2), KLRD1(1), MAP2K1(2), MAPK3(3), PAK1(1), PIK3CA(142), PIK3R1(106), PTK2B(13), RAC1(1), SYK(3), VAV1(10) 6800160 299 180 196 22 66 54 62 17 63 37 <1.00e-15 <9.78e-15 55 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(142), PIK3R1(106), PLCB1(4), PLCG1(8), PRKCA(7), VAV1(10) 4726136 280 180 176 27 59 46 61 17 60 37 <1.00e-15 <9.78e-15 56 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(2), EIF1(1), EIF2B2(4), EIF2B3(7), EIF2B4(3), EIF2B5(4), EIF2S2(5), EIF2S3(5), ELAVL1(6), FLT1(15), FLT4(9), HIF1A(12), KDR(20), NOS3(6), PIK3CA(142), PIK3R1(106), PLCG1(8), PRKCA(7), PTK2(8), PXN(4), SHC1(5), VHL(2) 11492816 381 180 276 46 88 87 69 22 78 37 <1.00e-15 <9.78e-15 57 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(3), CD3D(3), CD3E(1), CD3G(1), CD80(5), CD86(4), CTLA4(2), GRB2(3), ICOS(2), IL2(2), ITK(5), LCK(3), PIK3CA(142), PIK3R1(106), PTPN11(5) 4727872 287 179 184 15 61 53 61 14 61 37 <1.00e-15 <9.78e-15 58 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(7), DPM2(2), ELK1(2), FOS(2), GRB2(3), JUN(1), KLK2(2), MAP2K1(2), MAPK3(3), MAPK8(7), NGFR(3), PIK3CA(142), PIK3R1(106), PLCG1(8), RAF1(5), SHC1(5), SOS1(10) 6872824 310 178 203 15 70 59 65 18 61 37 <1.00e-15 <9.78e-15 59 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(3), AKT2(4), AKT3(7), CDKN1A(1), ELK1(2), GRB2(3), MAP2K1(2), NGFR(3), NTRK1(11), PIK3CA(142), PIK3CD(9), SHC1(5), SOS1(10) 5439136 202 130 118 19 64 58 53 15 12 0 <1.00e-15 <9.78e-15 60 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(5), ACTB(3), ACTG1(1), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(4), CDH1(12), CLDN1(2), CTNNB1(63), CTTN(4), EZR(4), FYN(6), HCLS1(8), ITGB1(5), LY96(3), NCK1(4), NCK2(7), NCL(3), OCLN(2), PRKCA(7), RHOA(3), ROCK1(15), ROCK2(10), TLR4(13), TLR5(6), TUBA1A(6), TUBA1B(1), TUBA1C(5), TUBA3C(3), TUBA3D(2), TUBA3E(10), TUBA4A(7), TUBA8(7), TUBAL3(3), TUBB1(5), TUBB2A(2), TUBB2B(1), TUBB6(4), TUBB8(3), WAS(8), WASL(7), YWHAQ(1), YWHAZ(1) 19346728 277 109 232 67 64 128 29 22 32 2 <1.00e-15 <9.78e-15 61 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(5), ACTB(3), ACTG1(1), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(4), CDH1(12), CLDN1(2), CTNNB1(63), CTTN(4), EZR(4), FYN(6), HCLS1(8), ITGB1(5), LY96(3), NCK1(4), NCK2(7), NCL(3), OCLN(2), PRKCA(7), RHOA(3), ROCK1(15), ROCK2(10), TLR4(13), TLR5(6), TUBA1A(6), TUBA1B(1), TUBA1C(5), TUBA3C(3), TUBA3D(2), TUBA3E(10), TUBA4A(7), TUBA8(7), TUBAL3(3), TUBB1(5), TUBB2A(2), TUBB2B(1), TUBB6(4), TUBB8(3), WAS(8), WASL(7), YWHAQ(1), YWHAZ(1) 19346728 277 109 232 67 64 128 29 22 32 2 <1.00e-15 <9.78e-15 62 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(42), CCNA1(3), CCNB1(7), CCND1(12), CCND2(7), CCND3(3), CCNE2(5), CCNG2(2), CCNH(3), CDC25A(7), CDK2(2), CDK4(3), CDK7(4), CDKN1A(1), CDKN1B(6), CDKN2A(1), CDKN2C(2), CDKN2D(1), CREB3L1(3), CREB3L3(7), CREB3L4(5), E2F1(6), E2F2(2), E2F3(3), E2F4(2), E2F6(1), GBA2(9), MCM2(4), MCM3(8), MCM4(6), MCM5(7), MCM6(4), MCM7(3), MDM2(3), MYC(6), NACA(17), PCNA(2), POLA2(1), POLE2(2), PRIM1(2), RB1(23), RBL1(13), RPA1(5), RPA2(2), RPA3(3), TFDP2(5), TNXB(16), TP53(48), WEE1(1) 27461536 330 108 310 77 81 120 41 21 59 8 <1.00e-15 <9.78e-15 63 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(42), ATR(26), BRCA1(14), CCNB1(7), CDC25A(7), CDC25B(2), CDC25C(5), CDKN1A(1), CDKN2D(1), CHEK1(2), CHEK2(11), EP300(23), MDM2(3), PRKDC(40), RPS6KA1(1), TP53(48), WEE1(1), YWHAH(2), YWHAQ(1) 15684512 237 87 219 49 46 73 41 18 55 4 <1.00e-15 <9.78e-15 64 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 122 ARAF(8), BID(2), BRAF(9), CASP3(3), CD244(3), CD247(3), CD48(1), FAS(6), FASLG(5), FCER1G(1), FCGR3A(1), FCGR3B(1), FYN(6), GRB2(3), GZMB(2), HCST(1), HLA-A(1), HLA-B(4), HLA-C(1), HLA-E(1), HLA-G(2), ICAM1(1), ICAM2(3), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(6), IFNAR2(6), IFNB1(2), IFNG(5), IFNGR1(5), IFNGR2(3), ITGAL(12), ITGB2(10), KIR2DL1(4), KIR2DL4(2), KIR3DL1(6), KIR3DL2(3), KLRC1(2), KLRC2(3), KLRC3(1), KLRD1(1), KLRK1(1), KRAS(27), LCK(3), LCP2(4), MAP2K1(2), MAPK1(2), MAPK3(3), MICB(2), NCR1(5), NCR2(3), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NRAS(8), PAK1(1), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG1(8), PLCG2(23), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRF1(6), PRKCA(7), PRKCG(6), PTK2B(13), PTPN11(5), RAC1(1), RAC2(2), RAF1(5), SH2D1A(3), SH2D1B(2), SH3BP2(7), SHC1(5), SHC3(9), SHC4(5), SOS1(10), SOS2(16), SYK(3), TNFRSF10A(2), TNFRSF10B(4), TNFRSF10C(2), TNFRSF10D(5), ULBP1(2), ULBP2(4), VAV1(10), VAV2(3), VAV3(9), ZAP70(6) 39412408 759 198 622 160 203 221 137 42 115 41 1.67e-15 1.60e-14 65 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(11), ATM(42), BAX(3), CCND1(12), CDK2(2), CDK4(3), CDKN1A(1), E2F1(6), MDM2(3), PCNA(2), RB1(23), TIMP3(8), TP53(48) 6526120 164 86 147 27 41 43 24 8 40 8 2.00e-15 1.89e-14 66 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 37 AKT1(3), AKT2(4), AKT3(7), BAD(2), BCR(4), BLNK(3), BTK(4), CD19(3), CSK(1), DAG1(4), EPHB2(8), GRB2(3), ITPKB(7), LYN(6), MAP2K1(2), MAPK1(2), NFAT5(10), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PI3(2), PIK3CA(142), PIK3CD(9), PIK3R1(106), PLCG2(23), PPP1R13B(5), RAF1(5), SERPINA4(4), SHC1(5), SOS1(10), SOS2(16), SYK(3), VAV1(10) 18046712 438 186 330 82 105 111 84 24 75 39 2.33e-15 2.18e-14 67 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 28 AKT1(3), AKT2(4), AKT3(7), ANKRD6(6), APC(36), AXIN1(7), CER1(2), CSNK1A1(4), CTNNB1(63), DACT1(10), DKK1(3), DKK2(3), DKK3(1), DKK4(3), FSTL1(2), GSK3A(8), GSK3B(8), LRP1(36), MVP(11), NKD1(3), PSEN1(5), PTPRA(7), SENP2(6), SFRP1(5), TSHB(3), WIF1(4) 13849312 250 105 201 58 71 103 30 21 21 4 2.55e-15 2.35e-14 68 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(42), ATR(26), CDC25C(5), CHEK1(2), CHEK2(11), TP53(48), YWHAH(2) 5967624 136 75 121 17 30 40 18 10 34 4 2.78e-15 2.51e-14 69 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(5), ACTR3(1), AKT1(3), ANGPTL2(4), DAG1(4), DGKA(9), ETFA(4), GCA(2), ITGA9(13), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), MAP2K1(2), MAPK1(2), MAPK3(3), NR1I3(5), PAK1(1), PDE3A(14), PDE3B(9), PI3(2), PIK3C2G(12), PIK3CA(142), PIK3CD(9), PIK3R1(106), PLDN(3), PSME1(1), RIPK3(2), RPS4X(1), SGCB(3), VASP(1) 17827976 433 187 328 79 94 110 87 17 86 39 3.33e-15 2.89e-14 70 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 63 APAF1(11), BAD(2), BAK1(3), BAX(3), BCL2L1(3), BCL2L11(5), BID(2), BIRC2(10), BIRC3(2), BIRC5(4), BNIP3L(1), CASP1(5), CASP10(8), CASP2(4), CASP3(3), CASP4(5), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CHUK(7), CYCS(2), DFFB(3), FAS(6), FASLG(5), GZMB(2), HELLS(8), IKBKB(8), IRF1(1), IRF2(6), IRF3(2), IRF4(6), IRF5(5), IRF6(7), JUN(1), LTA(2), MAP2K4(4), MAP3K1(24), MAPK10(7), MDM2(3), MYC(6), NFKB1(7), NFKBIA(2), NFKBIE(5), PLEKHG5(5), PRF1(6), RELA(4), RIPK1(8), TNFRSF10B(4), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TP53(48), TRAF1(5), TRAF2(2), TRAF3(4) 19716992 317 100 298 75 76 115 36 21 65 4 3.33e-15 2.89e-14 71 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(4), IFNG(5), IFNGR1(5), IFNGR2(3), IKBKB(8), JAK2(14), LIN7A(6), NFKB1(7), NFKBIA(2), RB1(23), RELA(4), TNFRSF1A(4), TNFRSF1B(1), TP53(48), USH1C(9), WT1(2) 6436592 145 74 132 34 33 43 23 7 31 8 3.33e-15 2.89e-14 72 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 95 ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CREB1(5), CREB3L1(3), CREB3L2(4), CREB3L3(7), CREB3L4(5), CREBBP(24), CTNNB1(63), DCT(11), DVL2(5), DVL3(7), EDN1(2), EP300(23), FZD1(3), FZD10(6), FZD2(5), FZD3(5), FZD4(4), FZD6(11), FZD7(4), FZD9(5), GNAI1(4), GNAI2(4), GNAI3(3), GNAO1(4), GNAS(16), GSK3B(8), KIT(22), KITLG(2), KRAS(27), LEF1(8), MAP2K1(2), MAPK1(2), MAPK3(3), MITF(3), NRAS(8), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), POMC(1), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), RAF1(5), TCF7(3), TCF7L1(2), TCF7L2(10), TYR(8), TYRP1(7), WNT1(1), WNT10A(1), WNT10B(1), WNT11(3), WNT16(4), WNT2(2), WNT2B(7), WNT3(3), WNT4(1), WNT5A(4), WNT5B(3), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(3), WNT9A(1), WNT9B(1) 36286616 567 147 485 182 155 218 88 41 65 0 3.77e-15 3.23e-14 73 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(36), AXIN1(7), CREBBP(24), CTNNB1(63), EP300(23), FZD1(3), GSK3B(8), HDAC1(3), LDB1(2), LEF1(8), PITX2(9), TRRAP(32), WNT1(1) 11299872 219 109 171 55 45 88 29 21 30 6 3.89e-15 3.28e-14 74 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT1(3), AKT2(4), AKT3(7), BCL10(2), CARD11(13), CBL(8), CBLB(11), CBLC(4), CD247(3), CD28(3), CD3D(3), CD3E(1), CD3G(1), CD4(6), CD40LG(5), CD8A(2), CD8B(1), CDC42(4), CDK4(3), CHUK(7), CTLA4(2), FOS(2), FYN(6), GRB2(3), ICOS(2), IFNG(5), IKBKB(8), IL10(2), IL2(2), IL5(1), ITK(5), JUN(1), KRAS(27), LCK(3), LCP2(4), MALT1(3), MAP3K14(4), MAP3K8(6), NCK1(4), NCK2(7), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NRAS(8), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PDK1(2), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKCQ(6), PTPRC(11), RASGRP1(6), RHOA(3), SOS1(10), SOS2(16), TEC(5), VAV1(10), VAV2(3), VAV3(9), ZAP70(6) 35340000 693 196 559 140 185 187 128 39 115 39 4.11e-15 3.42e-14 75 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 74 ABL1(5), ACTN1(7), ACTR2(5), ACTR3(1), AKT1(3), AKT2(4), AKT3(7), ANGPTL2(4), ARHGEF6(16), ARHGEF7(11), BRAF(9), CDC42(4), CDKN2A(1), CRK(1), CSE1L(10), DOCK1(17), EPHB2(8), FYN(6), GRB2(3), GRB7(4), ILK(4), ITGA1(13), ITGA10(7), ITGA11(6), ITGA2(14), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGB3BP(2), MAP2K4(4), MAP3K11(5), MAPK1(2), MAPK10(7), MAPK8(7), MAPK8IP1(4), MAPK9(4), MRAS(1), MYLK(10), MYLK2(6), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PIK3CA(142), PIK3CB(13), PKLR(5), PLCG1(8), PLCG2(23), PTEN(208), PTK2(8), RAF1(5), RALA(3), RHO(3), ROCK1(15), ROCK2(10), SHC1(5), SOS1(10), SOS2(16), SRC(2), TERF2IP(2), TLN1(20), TLN2(20), VASP(1), WAS(8), ZYX(11) 42913424 853 203 683 164 191 226 169 43 170 54 4.22e-15 3.42e-14 76 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 69 AKT1(3), AKT2(4), AKT3(7), BTK(4), FCER1A(7), FCER1G(1), FYN(6), GAB2(8), GRB2(3), IL5(1), INPP5D(9), KRAS(27), LCP2(4), LYN(6), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK8(7), MAPK9(4), MS4A2(2), NRAS(8), PDK1(2), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCG1(8), PLCG2(23), PRKCA(7), PRKCD(4), PRKCE(7), RAC1(1), RAC2(2), RAF1(5), SOS1(10), SOS2(16), SYK(3), VAV1(10), VAV2(3), VAV3(9) 24451560 594 195 460 105 153 158 113 33 96 41 4.22e-15 3.42e-14 77 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 79 ACVR1(9), ACVR1B(5), ACVRL1(1), AKT1(3), AURKB(3), BMPR1A(4), BMPR2(9), BUB1(7), CDKL1(6), CDKL2(5), CDS1(4), CLK1(7), CLK2(7), CLK4(5), CSNK2A1(7), CSNK2A2(3), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKZ(8), IMPA1(3), INPP1(2), INPP4A(16), INPP4B(12), INPP5A(4), INPPL1(14), ITPKB(7), MAP3K10(6), MOS(6), NEK1(17), NEK3(6), OCRL(15), PIK3C2A(14), PIK3C2B(10), PIK3C2G(12), PIK3CA(142), PIK3CB(13), PIK3CG(18), PIM2(3), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCG1(8), PLCG2(23), PLK3(7), PRKACA(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCQ(6), PRKCZ(3), PRKD1(6), PRKG1(4), RAF1(5), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA4(1), RPS6KB1(2), TGFBR1(3), VRK1(10) 40126152 674 169 578 185 196 223 122 42 89 2 4.44e-15 3.50e-14 78 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(7), DNAJC3(5), EIF2S2(5), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(4), TP53(48) 3536976 82 61 69 9 20 23 11 7 21 0 4.44e-15 3.50e-14 79 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(4), AKT3(7), CISH(1), GRB2(3), IARS(7), IL13RA1(10), IL2RG(11), IL4R(5), INPP5D(9), JAK1(16), JAK2(14), JAK3(5), NR0B2(2), PI3(2), PIK3CA(142), PPP1R13B(5), RPS6KB1(2), SERPINA4(4), SHC1(5), SOS1(10), SOS2(16), SRC(2), STAT6(5), TYK2(4) 13315864 294 135 209 53 79 91 71 19 28 6 4.55e-15 3.50e-14 80 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(3), AKT2(4), AKT3(7), BAD(2), BCL2L1(3), CDC42(4), CDK2(2), CDKN1B(6), CDKN2A(1), CREB1(5), CREB5(3), ERBB4(19), F2RL2(2), GAB1(5), GRB2(3), GSK3A(8), GSK3B(8), IGF1(2), IGFBP1(4), INPPL1(14), IRS1(10), IRS4(16), MET(9), MYC(6), NOLC1(10), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PARD3(19), PDK1(2), PIK3CA(142), PIK3CD(9), PPP1R13B(5), PREX1(17), PTEN(208), PTK2(8), PTPN1(4), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KB1(2), SHC1(5), SLC2A4(5), SOS1(10), SOS2(16), TSC1(9), TSC2(13), YWHAE(2), YWHAG(3), YWHAH(2), YWHAQ(1), YWHAZ(1) 26511696 694 202 531 117 141 175 154 35 139 50 4.66e-15 3.50e-14 81 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 231 ACVR1B(5), ACVR1C(3), AKT1(3), AKT2(4), AKT3(7), ARRB1(4), ARRB2(3), ATF2(6), ATF4(3), BDNF(6), BRAF(9), CACNA1A(15), CACNA1C(21), CACNA1D(23), CACNA1E(40), CACNA1F(30), CACNA1G(16), CACNA1I(5), CACNA1S(22), CACNA2D1(9), CACNA2D2(8), CACNA2D3(17), CACNA2D4(13), CACNB1(7), CACNB2(9), CACNB3(4), CACNB4(11), CACNG2(2), CACNG3(8), CACNG4(6), CACNG5(4), CACNG6(4), CACNG7(7), CASP3(3), CD14(2), CDC25B(2), CDC42(4), CHUK(7), CRK(1), CRKL(4), DAXX(6), DDIT3(1), DUSP1(2), DUSP10(5), DUSP14(3), DUSP16(8), DUSP3(1), DUSP5(3), DUSP6(1), DUSP7(3), DUSP9(1), ECSIT(3), EGF(17), EGFR(10), ELK1(2), ELK4(2), FAS(6), FASLG(5), FGF10(1), FGF11(1), FGF12(2), FGF13(4), FGF14(3), FGF18(1), FGF21(1), FGF23(3), FGF5(6), FGF6(1), FGF7(4), FGF8(1), FGF9(1), FGFR1(7), FGFR2(27), FGFR4(8), FLNA(27), FLNB(28), FLNC(27), FOS(2), GNA12(7), GNG12(1), GRB2(3), IKBKB(8), IL1B(2), IL1R1(4), IL1R2(5), JUN(1), KRAS(27), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K5(2), MAP2K6(6), MAP3K1(24), MAP3K10(6), MAP3K12(6), MAP3K13(11), MAP3K14(4), MAP3K2(8), MAP3K3(6), MAP3K4(16), MAP3K5(19), MAP3K6(4), MAP3K7(8), MAP3K8(6), MAP4K1(9), MAP4K2(6), MAP4K3(14), MAP4K4(7), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK7(11), MAPK8(7), MAPK8IP1(4), MAPK9(4), MAPKAPK2(4), MAPKAPK3(2), MAPKAPK5(4), MAPT(9), MAX(4), MEF2C(8), MKNK1(3), MKNK2(3), MOS(6), MRAS(1), MYC(6), NF1(30), NFATC2(9), NFATC4(7), NFKB1(7), NFKB2(9), NLK(5), NR4A1(4), NRAS(8), NTF3(4), NTRK1(11), NTRK2(11), PAK1(1), PAK2(3), PDGFB(2), PDGFRA(19), PDGFRB(10), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PPM1A(6), PPM1B(3), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PPP5C(4), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), PTPN5(4), PTPN7(4), PTPRR(13), RAC1(1), RAC2(2), RAF1(5), RAP1A(3), RAP1B(2), RAPGEF2(26), RASA1(23), RASA2(7), RASGRF1(8), RASGRF2(11), RASGRP1(6), RASGRP2(2), RASGRP3(5), RASGRP4(5), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA4(1), RPS6KA5(7), RPS6KA6(12), RRAS(1), RRAS2(4), SOS1(10), SOS2(16), SRF(2), STK3(7), STK4(5), STMN1(4), TAOK1(9), TAOK2(6), TAOK3(3), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), TNFRSF1A(4), TP53(48), TRAF2(2), TRAF6(3), ZAK(11) 99014000 1474 182 1392 429 400 564 185 104 201 20 4.77e-15 3.50e-14 82 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(11), BAK1(3), BAX(3), BCL2L1(3), BID(2), BIRC2(10), BIRC3(2), CASP2(4), CASP3(3), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CYCS(2), FAS(6), FASLG(5), GZMB(2), JUN(1), MAP2K4(4), MAP3K1(24), MAP3K14(4), MAPK10(7), MCL1(1), MDM2(3), MYC(6), NFKB1(7), NFKBIA(2), PARP1(9), PRF1(6), RELA(4), RIPK1(8), TNFRSF1A(4), TNFRSF1B(1), TP53(48), TRAF1(5), TRAF2(2) 13230800 223 89 206 48 57 69 31 20 42 4 4.77e-15 3.50e-14 83 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(5), ATM(42), BRCA1(14), CDKN1A(1), CHEK1(2), CHEK2(11), JUN(1), MAPK8(7), MDM2(3), MRE11A(9), NFKB1(7), NFKBIA(2), RAD50(15), RAD51(2), RBBP8(8), RELA(4), TP53(48) 10615640 181 83 166 37 37 59 26 12 41 6 4.77e-15 3.50e-14 84 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 64 AKT1(3), AKT2(4), AKT3(7), BAD(2), CASP9(2), CDC42(4), KDR(20), KRAS(27), MAP2K1(2), MAPK1(2), MAPK13(2), MAPK14(4), MAPK3(3), MAPKAPK2(4), MAPKAPK3(2), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NOS3(6), NRAS(8), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCG1(8), PLCG2(23), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKCA(7), PRKCG(6), PTGS2(6), PTK2(8), PXN(4), RAC1(1), RAC2(2), RAF1(5), SPHK1(2), SPHK2(1), SRC(2) 23650768 560 192 429 97 147 146 104 32 94 37 4.88e-15 3.50e-14 85 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 30 ACVR1(9), APC(36), ATF2(6), AXIN1(7), BMP10(7), BMP2(5), BMP4(7), BMP5(12), BMP7(10), BMPR1A(4), BMPR2(9), CHRD(8), CTNNB1(63), FZD1(3), GATA4(1), GSK3B(8), MAP3K7(8), MEF2C(8), MYL2(1), NOG(2), NPPA(1), NPPB(2), RFC1(13), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), TGFBR3(8), WNT1(1) 12350648 263 108 214 44 63 120 32 19 25 4 4.88e-15 3.50e-14 86 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(3), MAX(4), MYC(6), SP1(6), SP3(8), TP53(48), WT1(2) 2524640 77 61 64 10 19 27 7 5 17 2 4.88e-15 3.50e-14 87 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 193 ABI2(1), ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), APC(36), ARAF(8), ARHGEF1(9), ARHGEF12(19), ARHGEF4(5), ARHGEF6(16), ARHGEF7(11), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), ARPC5(1), BDKRB1(2), BDKRB2(7), BRAF(9), CD14(2), CDC42(4), CFL1(1), CFL2(7), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), CRK(1), CRKL(4), CSK(1), CYFIP1(7), CYFIP2(17), DIAPH1(10), DIAPH2(18), DIAPH3(24), DOCK1(17), EGF(17), EGFR(10), EZR(4), F2(8), F2R(6), FGD1(10), FGD3(8), FGF10(1), FGF11(1), FGF12(2), FGF13(4), FGF14(3), FGF18(1), FGF21(1), FGF23(3), FGF5(6), FGF6(1), FGF7(4), FGF8(1), FGF9(1), FGFR1(7), FGFR2(27), FGFR4(8), FN1(31), GIT1(8), GNA12(7), GNA13(7), GNG12(1), GSN(4), IQGAP1(9), IQGAP2(21), IQGAP3(15), ITGA1(13), ITGA10(7), ITGA11(6), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGAD(5), ITGAE(7), ITGAL(12), ITGAM(19), ITGAV(6), ITGAX(7), ITGB1(5), ITGB2(10), ITGB3(10), ITGB4(6), ITGB5(4), ITGB6(4), ITGB7(4), ITGB8(4), KRAS(27), LIMK1(6), LIMK2(10), MAP2K1(2), MAPK1(2), MAPK3(3), MOS(6), MRAS(1), MSN(12), MYH10(23), MYH14(17), MYH9(18), MYL2(1), MYL5(1), MYL7(3), MYL9(3), MYLK(10), MYLK2(6), MYLPF(2), NCKAP1(6), NCKAP1L(13), NRAS(8), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PDGFB(2), PDGFRA(19), PDGFRB(10), PFN1(1), PFN2(1), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PIP4K2A(2), PIP4K2B(7), PIP4K2C(3), PIP5K1A(6), PIP5K1B(3), PIP5K1C(4), PPP1CA(3), PPP1CB(4), PPP1CC(2), PPP1R12A(8), PPP1R12B(11), PTK2(8), PXN(4), RAC1(1), RAC2(2), RAF1(5), RDX(11), RHOA(3), ROCK1(15), ROCK2(10), RRAS(1), RRAS2(4), SCIN(3), SLC9A1(6), SOS1(10), SOS2(16), SSH1(10), SSH2(7), SSH3(3), TIAM1(20), TIAM2(14), VAV1(10), VAV2(3), VAV3(9), VCL(8), WAS(8), WASF1(3), WASF2(3), WASL(7) 96510688 1561 213 1392 423 398 543 246 92 225 57 5.11e-15 3.57e-14 88 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 103 ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), ARHGAP5(18), CD99(1), CDC42(4), CDH5(3), CLDN1(2), CLDN10(7), CLDN11(1), CLDN15(4), CLDN16(4), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CTNNA1(15), CTNNA2(9), CTNNA3(8), CTNNB1(63), CTNND1(17), CXCL12(2), CXCR4(1), CYBB(8), EZR(4), F11R(1), GNAI1(4), GNAI2(4), GNAI3(3), ICAM1(1), ITGA4(8), ITGAL(12), ITGAM(19), ITGB1(5), ITGB2(10), ITK(5), JAM2(7), JAM3(2), MAPK13(2), MAPK14(4), MLLT4(17), MMP2(6), MMP9(11), MSN(12), MYL2(1), MYL5(1), MYL7(3), MYL9(3), MYLPF(2), NCF1(3), NCF2(4), NCF4(5), NOX1(10), NOX3(2), OCLN(2), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG1(8), PLCG2(23), PRKCA(7), PRKCG(6), PTK2(8), PTK2B(13), PTPN11(5), PXN(4), RAC1(1), RAC2(2), RAP1A(3), RAP1B(2), RAPGEF3(7), RAPGEF4(9), RASSF5(2), RHOA(3), RHOH(1), ROCK1(15), ROCK2(10), SIPA1(1), THY1(1), TXK(6), VASP(1), VAV1(10), VAV2(3), VAV3(9), VCAM1(9), VCL(8) 43336512 873 212 718 219 224 278 139 58 131 43 5.11e-15 3.57e-14 89 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 20 APC(36), AXIN1(7), BTRC(11), CCND1(12), CREBBP(24), CSNK1A1(4), CSNK2A1(7), CTNNB1(63), FZD1(3), GSK3B(8), HDAC1(3), MAP3K7(8), MYC(6), NLK(5), PPARD(3), PPP2CA(4), TLE1(8), WIF1(4), WNT1(1) 9664312 217 113 169 32 51 90 24 20 26 6 5.22e-15 3.57e-14 90 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(26), AKT1(3), ATM(42), BAX(3), CDKN1A(1), CPB2(6), CSNK1A1(4), FHL2(1), HIF1A(12), IGFBP3(3), MAPK8(7), MDM2(3), NQO1(3), TP53(48) 7311288 162 84 145 39 44 39 26 9 38 6 5.22e-15 3.57e-14 91 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 44 IMPA1(3), IMPA2(5), INPP1(2), INPP4A(16), INPP4B(12), INPP5A(4), INPP5B(4), INPPL1(14), IPMK(4), ITPK1(2), ITPKB(7), MINPP1(1), OCRL(15), PI4KA(9), PI4KB(6), PIK3C3(9), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIP4K2A(2), PIP4K2B(7), PIP4K2C(3), PIP5K1A(6), PIP5K1B(3), PIP5K1C(4), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(3), PLCD4(10), PLCE1(31), PLCG1(8), PLCG2(23), PLCZ1(11), PTEN(208), PTPMT1(1), SYNJ1(24), SYNJ2(8) 25313856 688 197 526 129 155 164 146 32 141 50 5.55e-15 3.76e-14 92 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(24), DAXX(6), PAX3(4), PML(6), RARA(1), RB1(23), SIRT1(4), SP100(10), TNFRSF1A(4), TNFRSF1B(1), TP53(48) 6675912 131 70 117 24 34 43 17 5 28 4 5.66e-15 3.79e-14 93 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(3), AKT2(4), AKT3(7), BCL10(2), BLNK(3), BTK(4), CARD11(13), CD19(3), CD22(11), CD72(1), CD79B(2), CHUK(7), CR2(19), FCGR2B(3), FOS(2), GSK3B(8), IKBKB(8), INPP5D(9), JUN(1), KRAS(27), LILRB3(2), LYN(6), MALT1(3), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NRAS(8), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG2(23), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), RAC1(1), RAC2(2), RASGRP3(5), SYK(3), VAV1(10), VAV2(3), VAV3(9) 25554168 589 194 459 108 159 158 108 29 98 37 5.77e-15 3.82e-14 94 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 123 ACACA(27), ACACB(25), AKT1(3), AKT2(4), AKT3(7), ARAF(8), BAD(2), BRAF(9), CALM2(3), CALML6(3), CBL(8), CBLB(11), CBLC(4), CRK(1), CRKL(4), ELK1(2), EXOC7(3), FBP1(2), FLOT2(1), FOXO1(9), G6PC(5), G6PC2(4), GCK(3), GRB2(3), GSK3B(8), GYS1(9), GYS2(14), IKBKB(8), INPP5D(9), INSR(12), IRS1(10), IRS4(16), KRAS(27), LIPE(7), MAP2K1(2), MAPK1(2), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(4), MKNK1(3), MKNK2(3), NRAS(8), PCK1(8), PCK2(7), PDE3A(14), PDE3B(9), PDPK1(2), PFKM(4), PFKP(6), PHKA1(13), PHKA2(12), PHKB(10), PHKG1(5), PHKG2(2), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PKLR(5), PKM2(4), PPARGC1A(8), PPP1CA(3), PPP1CB(4), PPP1CC(2), PPP1R3A(17), PPP1R3B(2), PPP1R3C(3), PRKAA1(5), PRKAA2(7), PRKAB1(6), PRKAB2(1), PRKACA(4), PRKACG(7), PRKAG1(2), PRKAG2(3), PRKAG3(5), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCI(6), PRKCZ(3), PRKX(2), PTPN1(4), PTPRF(19), PYGB(9), PYGL(6), PYGM(4), RAF1(5), RAPGEF1(9), RHEB(2), RHOQ(1), RPS6(6), RPS6KB1(2), RPS6KB2(4), SH2B2(1), SHC1(5), SHC3(9), SHC4(5), SLC2A4(5), SOCS2(6), SOCS4(3), SORBS1(14), SOS1(10), SOS2(16), SREBF1(2), TRIP10(6), TSC1(9), TSC2(13) 52804904 997 207 851 221 257 324 174 39 158 45 5.88e-15 3.86e-14 95 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 135 APC(36), AXIN1(7), BTRC(11), CACYBP(2), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CCND1(12), CCND2(7), CCND3(3), CER1(2), CHD8(30), CREBBP(24), CSNK1A1(4), CSNK1A1L(2), CSNK1E(3), CSNK2A1(7), CSNK2A2(3), CTBP2(5), CTNNB1(63), CUL1(12), DAAM1(14), DAAM2(6), DKK1(3), DKK2(3), DKK4(3), DVL2(5), DVL3(7), EP300(23), FBXW11(4), FOSL1(3), FZD1(3), FZD10(6), FZD2(5), FZD3(5), FZD4(4), FZD6(11), FZD7(4), FZD9(5), GSK3B(8), JUN(1), LEF1(8), LRP5(12), LRP6(16), MAP3K7(8), MAPK10(7), MAPK8(7), MAPK9(4), MYC(6), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NKD1(3), NLK(5), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PORCN(10), PPARD(3), PPP2CA(4), PPP2CB(2), PPP2R1A(30), PPP2R1B(5), PPP2R2A(10), PPP2R2B(7), PPP2R2C(2), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRICKLE1(5), PRICKLE2(2), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), PSEN1(5), RAC1(1), RAC2(2), RBX1(1), RHOA(3), ROCK1(15), ROCK2(10), RUVBL1(1), SENP2(6), SFRP1(5), SFRP2(2), SFRP4(9), SFRP5(2), SIAH1(3), SMAD2(7), SMAD3(5), SMAD4(3), TBL1X(5), TBL1XR1(11), TCF7(3), TCF7L1(2), TCF7L2(10), TP53(48), VANGL1(4), VANGL2(6), WIF1(4), WNT1(1), WNT10A(1), WNT10B(1), WNT11(3), WNT16(4), WNT2(2), WNT2B(7), WNT3(3), WNT4(1), WNT5A(4), WNT5B(3), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(3), WNT9A(1), WNT9B(1) 54523544 847 191 763 226 220 341 103 63 110 10 6.44e-15 4.09e-14 96 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 82 ABL1(5), ABL2(17), AKT1(3), AKT2(4), AKT3(7), ARAF(8), BAD(2), BRAF(9), BTC(1), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CBL(8), CBLB(11), CBLC(4), CDKN1A(1), CDKN1B(6), CRK(1), CRKL(4), EGF(17), EGFR(10), ELK1(2), ERBB2(3), ERBB3(14), ERBB4(19), EREG(3), GAB1(5), GRB2(3), GSK3B(8), HBEGF(2), JUN(1), KRAS(27), MAP2K1(2), MAP2K4(4), MAPK1(2), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(4), MYC(6), NCK1(4), NCK2(7), NRAS(8), NRG1(20), NRG2(2), NRG3(11), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG1(8), PLCG2(23), PRKCA(7), PRKCG(6), PTK2(8), RAF1(5), RPS6KB1(2), RPS6KB2(4), SHC1(5), SHC3(9), SHC4(5), SOS1(10), SOS2(16), SRC(2), STAT5A(2), STAT5B(3) 35542616 753 196 617 137 195 217 139 41 118 43 6.55e-15 4.09e-14 97 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 126 ACTB(3), ACTG1(1), ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), AKT1(3), AKT2(4), AKT3(7), AMOTL1(10), ASH1L(32), CASK(13), CDC42(4), CDK4(3), CGN(9), CLDN1(2), CLDN10(7), CLDN11(1), CLDN15(4), CLDN16(4), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CSDA(2), CSNK2A1(7), CSNK2A2(3), CTNNA1(15), CTNNA2(9), CTNNA3(8), CTNNB1(63), CTTN(4), EPB41(9), EPB41L1(10), EPB41L2(11), EPB41L3(16), EXOC3(6), EXOC4(1), F11R(1), GNAI1(4), GNAI2(4), GNAI3(3), HCLS1(8), IGSF5(6), INADL(13), JAM2(7), JAM3(2), KRAS(27), LLGL1(9), LLGL2(4), MAGI1(20), MAGI2(23), MAGI3(12), MLLT4(17), MPDZ(16), MPP5(5), MRAS(1), MYH1(34), MYH10(23), MYH11(25), MYH13(17), MYH14(17), MYH15(19), MYH2(31), MYH3(20), MYH4(21), MYH6(12), MYH7(26), MYH7B(10), MYH8(25), MYH9(18), MYL2(1), MYL5(1), MYL7(3), MYL9(3), MYLPF(2), NRAS(8), OCLN(2), PARD3(19), PARD6B(2), PPM1J(2), PPP2CA(4), PPP2CB(2), PPP2R1A(30), PPP2R1B(5), PPP2R2A(10), PPP2R2B(7), PPP2R2C(2), PPP2R3A(10), PPP2R4(4), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCI(6), PRKCQ(6), PRKCZ(3), PTEN(208), RAB13(2), RAB3B(1), RHOA(3), RRAS(1), RRAS2(4), SPTAN1(23), SRC(2), SYMPK(15), TJAP1(5), TJP1(18), TJP2(13), TJP3(5), VAPA(5), YES1(6), ZAK(11) 68851992 1285 209 1108 326 298 424 210 76 219 58 6.66e-15 4.09e-14 98 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(7), ACTN2(7), ACTN3(6), CSK(1), CTNNA1(15), CTNNA2(9), CTNNB1(63), PTK2(8), PXN(4), SRC(2), VCL(8) 6883488 130 85 83 37 32 52 17 14 15 0 6.66e-15 4.09e-14 99 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 148 AKT1(3), AKT2(4), AKT3(7), BCL2L1(3), CBL(8), CBLB(11), CBLC(4), CCND1(12), CCND2(7), CCND3(3), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(24), CSF2RA(7), CSF2RB(9), CSF3(1), CSF3R(7), EP300(23), EPO(1), EPOR(3), GH1(2), GH2(2), GHR(8), GRB2(3), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(6), IFNAR2(6), IFNB1(2), IFNG(5), IFNGR1(5), IFNGR2(3), IFNK(2), IFNW1(1), IL10(2), IL10RA(3), IL10RB(6), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL13RA1(10), IL13RA2(3), IL15(1), IL19(1), IL2(2), IL20(5), IL20RA(1), IL21(2), IL21R(6), IL22RA1(2), IL22RA2(1), IL23A(4), IL23R(4), IL24(5), IL26(3), IL28A(2), IL28B(1), IL28RA(7), IL29(2), IL2RA(2), IL2RB(1), IL2RG(11), IL3RA(8), IL4R(5), IL5(1), IL5RA(7), IL6(4), IL6R(7), IL6ST(6), IL7(1), IL7R(7), IL9R(1), IRF9(4), JAK1(16), JAK2(14), JAK3(5), LEP(1), LEPR(10), LIF(2), LIFR(19), MPL(4), MYC(6), OSM(1), OSMR(11), PIAS1(3), PIAS2(12), PIAS3(7), PIAS4(4), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PIM1(3), PRL(4), PRLR(3), PTPN11(5), SOCS2(6), SOCS4(3), SOCS5(9), SOCS7(4), SOS1(10), SOS2(16), SPRED1(2), SPRED2(6), SPRY1(3), SPRY2(4), SPRY4(1), STAM(7), STAM2(4), STAT1(12), STAT2(5), STAT3(8), STAT4(6), STAT5A(2), STAT5B(3), STAT6(5), TPO(11), TSLP(1), TYK2(4) 51878128 947 209 828 220 236 293 160 59 154 45 6.77e-15 4.09e-14 100 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 36 AKT1(3), ATF2(6), CDC42(4), DLD(3), DUSP10(5), GAB1(5), GCK(3), IL1R1(4), JUN(1), MAP2K4(4), MAP2K5(2), MAP3K1(24), MAP3K10(6), MAP3K11(5), MAP3K12(6), MAP3K13(11), MAP3K2(8), MAP3K3(6), MAP3K4(16), MAP3K5(19), MAP3K7(8), MAP3K9(3), MAPK10(7), MAPK7(11), MAPK8(7), MAPK9(4), MYEF2(5), NFATC3(9), NR2C2(5), PAPPA(26), SHC1(5), TP53(48), TRAF6(3), ZAK(11) 17694552 293 101 278 76 91 102 32 15 49 4 6.77e-15 4.09e-14 101 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(5), ATM(42), ATR(26), CCNA1(3), CCND1(12), CDC25A(7), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN1B(6), CDKN2A(1), DHFR(3), E2F1(6), GSK3B(8), HDAC1(3), RB1(23), SKP2(4), TGFB1(2), TGFB2(5), TGFB3(8), TP53(48) 10891416 221 96 204 46 43 78 29 11 50 10 6.77e-15 4.09e-14 102 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 10 ADAM17(8), APC(36), AXIN1(7), BTRC(11), CTNNB1(63), DLL1(6), FZD1(3), GSK3B(8), PSEN1(5), WNT1(1) 5656384 148 91 103 26 30 69 15 17 13 4 6.77e-15 4.09e-14 103 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(3), EGFR(10), IGF1R(10), MYC(6), POLR2A(17), PPP2CA(4), PRKCA(7), RB1(23), TEP1(9), TERF1(1), TERT(3), TNKS(13), TP53(48), XRCC5(5) 10034080 159 78 145 47 40 56 17 10 32 4 7.11e-15 4.25e-14 104 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(3), ARF3(2), CCND1(12), CDK2(2), CDK4(3), CDKN1A(1), CDKN1B(6), CDKN2A(1), CFL1(1), E2F1(6), E2F2(2), MDM2(3), PRB1(2), TP53(48) 2864152 92 71 79 17 21 28 11 9 23 0 7.33e-15 4.34e-14 105 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 104 ABL1(5), ANAPC1(18), ANAPC10(1), ANAPC2(5), ANAPC4(5), ANAPC5(7), ANAPC7(3), ATM(42), ATR(26), BUB1(7), BUB1B(4), BUB3(2), CCNA1(3), CCNA2(2), CCNB1(7), CCNB2(3), CCNB3(19), CCND1(12), CCND2(7), CCND3(3), CCNE2(5), CCNH(3), CDC14A(4), CDC14B(5), CDC16(1), CDC20(4), CDC23(3), CDC25A(7), CDC25B(2), CDC25C(5), CDC27(13), CDC6(1), CDC7(10), CDK2(2), CDK4(3), CDK6(3), CDK7(4), CDKN1A(1), CDKN1B(6), CDKN2A(1), CDKN2C(2), CDKN2D(1), CHEK1(2), CHEK2(11), CREBBP(24), CUL1(12), DBF4(11), E2F1(6), E2F2(2), E2F3(3), EP300(23), ESPL1(5), GSK3B(8), HDAC1(3), HDAC2(4), MAD1L1(11), MAD2L1(3), MAD2L2(2), MCM2(4), MCM3(8), MCM4(6), MCM5(7), MCM6(4), MCM7(3), MDM2(3), PCNA(2), PLK1(3), PRKDC(40), PTTG1(2), RB1(23), RBL1(13), RBL2(15), RBX1(1), SKP2(4), SMAD2(7), SMAD3(5), SMAD4(3), SMC1A(13), SMC1B(15), TGFB1(2), TGFB2(5), TGFB3(8), TP53(48), WEE1(1), YWHAE(2), YWHAG(3), YWHAH(2), YWHAQ(1), YWHAZ(1) 49061344 651 139 621 154 143 261 87 36 107 17 7.44e-15 4.36e-14 106 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(3), ACTB(3), ACTG1(1), ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), ACVR1B(5), ACVR1C(3), CDC42(4), CDH1(12), CREBBP(24), CSNK2A1(7), CSNK2A2(3), CTNNA1(15), CTNNA2(9), CTNNA3(8), CTNNB1(63), CTNND1(17), EGFR(10), EP300(23), ERBB2(3), FARP2(13), FER(10), FGFR1(7), FYN(6), IGF1R(10), INSR(12), IQGAP1(9), LEF1(8), LMO7(17), MAP3K7(8), MAPK1(2), MAPK3(3), MET(9), MLLT4(17), NLK(5), PARD3(19), PTPN1(4), PTPRB(19), PTPRF(19), PTPRJ(10), PTPRM(14), PVRL1(6), PVRL2(3), PVRL3(5), PVRL4(4), RAC1(1), RAC2(2), RHOA(3), SMAD2(7), SMAD3(5), SMAD4(3), SNAI1(2), SNAI2(5), SORBS1(14), SRC(2), SSX2IP(8), TCF7(3), TCF7L1(2), TCF7L2(10), TGFBR1(3), TGFBR2(6), TJP1(18), VCL(8), WAS(8), WASF1(3), WASF2(3), WASF3(7), WASL(7), YES1(6) 43034944 614 141 554 166 151 241 85 45 92 0 7.88e-15 4.58e-14 107 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(42), ATR(26), BRCA1(14), BRCA2(42), CHEK1(2), CHEK2(11), FANCC(6), FANCD2(8), FANCE(8), FANCG(7), HUS1(3), MRE11A(9), RAD1(3), RAD17(7), RAD50(15), RAD51(2), RAD9A(2), TP53(48) 16318648 255 90 238 38 62 86 38 15 46 8 8.22e-15 4.69e-14 108 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(42), CDC25A(7), CDC25B(2), CDC25C(5), CDK2(2), CDK4(3), CHEK1(2), RB1(23), TP53(48), WEE1(1), YWHAH(2) 6469824 137 76 121 17 33 36 23 4 33 8 8.22e-15 4.69e-14 109 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(3), APAF1(11), ATM(42), BAD(2), BAX(3), BCL2L1(3), BID(2), CASP3(3), CASP6(3), CASP7(4), CASP9(2), CYCS(2), PRKCA(7), PTK2(8), PXN(4), STAT1(12), TLN1(20), TP53(48) 10061360 179 85 164 36 49 51 28 10 37 4 8.99e-15 5.08e-14 110 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 55 APC(36), AXIN1(7), CCND1(12), CCND2(7), CCND3(3), CSNK1E(3), CTNNB1(63), DVL2(5), DVL3(7), FBXW2(3), FOSL1(3), FZD1(3), FZD10(6), FZD2(5), FZD3(5), FZD6(11), FZD7(4), FZD9(5), GSK3B(8), JUN(1), LDLR(6), MAPK10(7), MAPK9(4), MYC(6), PAFAH1B1(1), PLAU(4), PPP2R5C(4), PPP2R5E(5), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCI(6), PRKCQ(6), PRKCZ(3), PRKD1(6), RAC1(1), RHOA(3), SFRP4(9), TCF7(3), WNT1(1), WNT10A(1), WNT10B(1), WNT11(3), WNT16(4), WNT2(2), WNT2B(7), WNT3(3), WNT4(1), WNT5A(4), WNT5B(3), WNT7A(2), WNT7B(1) 19625728 335 122 282 110 88 134 42 32 33 6 9.21e-15 5.16e-14 111 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 185 ACTB(3), ACTG1(1), ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), AKT1(3), AKT2(4), AKT3(7), ARHGAP5(18), BAD(2), BIRC2(10), BIRC3(2), BRAF(9), CAPN2(5), CAV2(1), CCND1(12), CCND2(7), CCND3(3), CDC42(4), CHAD(1), COL11A1(22), COL11A2(6), COL1A1(7), COL1A2(15), COL2A1(10), COL3A1(12), COL4A1(15), COL4A2(5), COL4A4(17), COL4A6(28), COL5A1(24), COL5A2(17), COL5A3(17), COL6A3(34), COL6A6(20), COMP(3), CRK(1), CRKL(4), CTNNB1(63), DIAPH1(10), DOCK1(17), EGF(17), EGFR(10), ELK1(2), ERBB2(3), FARP2(13), FIGF(5), FLNA(27), FLNB(28), FLNC(27), FLT1(15), FN1(31), FYN(6), GRB2(3), GSK3B(8), HGF(13), IBSP(5), IGF1(2), IGF1R(10), ILK(4), ITGA1(13), ITGA10(7), ITGA11(6), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGAV(6), ITGB1(5), ITGB3(10), ITGB4(6), ITGB5(4), ITGB6(4), ITGB7(4), ITGB8(4), JUN(1), KDR(20), LAMA1(27), LAMA2(52), LAMA3(22), LAMA4(13), LAMB1(21), LAMB2(20), LAMB3(12), LAMB4(22), LAMC1(13), LAMC2(11), LAMC3(10), MAP2K1(2), MAPK1(2), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(4), MET(9), MYL2(1), MYL5(1), MYL7(3), MYL9(3), MYLK(10), MYLK2(6), MYLPF(2), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PARVA(3), PARVB(1), PARVG(2), PDGFB(2), PDGFC(2), PDGFD(6), PDGFRA(19), PDGFRB(10), PDPK1(2), PGF(1), PIK3CA(142), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R1(106), PIK3R2(3), PIK3R3(9), PIK3R5(7), PIP5K1C(4), PPP1CA(3), PPP1CB(4), PPP1CC(2), PPP1R12A(8), PRKCA(7), PRKCG(6), PTEN(208), PTK2(8), PXN(4), RAC1(1), RAC2(2), RAF1(5), RAP1A(3), RAP1B(2), RAPGEF1(9), RELN(36), RHOA(3), ROCK1(15), ROCK2(10), SHC1(5), SHC3(9), SHC4(5), SOS1(10), SOS2(16), SPP1(2), SRC(2), THBS1(9), THBS2(17), THBS3(2), THBS4(6), TLN1(20), TLN2(20), TNC(14), TNN(11), TNR(11), TNXB(16), VASP(1), VAV1(10), VAV2(3), VAV3(9), VCL(8), VEGFB(2), VEGFC(6), VWF(19), ZYX(11) 128844184 2120 227 1869 542 477 724 329 116 353 121 9.99e-15 5.55e-14 112 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(3), INPP1(2), INPP4A(16), INPP4B(12), INPP5A(4), INPPL1(14), ITPKB(7), OCRL(15), PIK3C2A(14), PIK3C2B(10), PIK3C2G(12), PIK3CA(142), PIK3CB(13), PIK3CG(18), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCG1(8), PLCG2(23) 16225152 354 148 267 75 105 109 71 22 45 2 1.12e-14 6.17e-14 113 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(3), AKT2(4), AKT3(7), BAD(2), BCR(4), BLNK(3), BTK(4), CD19(3), CD22(11), CR2(19), CSK(1), DAG1(4), FLOT2(1), GRB2(3), GSK3A(8), GSK3B(8), INPP5D(9), ITPR1(23), ITPR2(25), ITPR3(15), LYN(6), MAP4K1(9), MAPK1(2), MAPK3(3), NFATC2(9), NR0B2(2), PDK1(2), PIK3CA(142), PIK3CD(9), PIK3R1(106), PLCG2(23), PPP1R13B(5), PPP3CA(2), PPP3CB(5), PPP3CC(4), PTPRC(11), RAF1(5), SHC1(5), SOS1(10), SOS2(16), SYK(3), VAV1(10) 26176400 546 189 436 109 140 153 103 25 84 41 1.47e-14 7.99e-14 114 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CDK2(2), CUL1(12), E2F1(6), FBXW7(32), RB1(23) 2958392 75 44 67 8 15 29 10 3 12 6 4.17e-14 2.26e-13 115 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(5), ATM(42), BUB1(7), BUB1B(4), BUB3(2), CCNA1(3), CCNA2(2), CCNB1(7), CCNB2(3), CCNB3(19), CCND2(7), CCND3(3), CCNE2(5), CCNH(3), CDAN1(8), CDC14A(4), CDC14B(5), CDC20(4), CDC25A(7), CDC25B(2), CDC25C(5), CDC6(1), CDC7(10), CDH1(12), CDK2(2), CDK4(3), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(11), DTX4(4), E2F1(6), E2F2(2), E2F3(3), E2F4(2), E2F6(1), EP300(23), ESPL1(5), GSK3B(8), HDAC1(3), HDAC2(4), HDAC3(8), HDAC4(12), HDAC5(10), HDAC6(12), HDAC8(2), MAD1L1(11), MAD2L1(3), MAD2L2(2), MCM2(4), MCM3(8), MCM4(6), MCM5(7), MCM6(4), MCM7(3), MDM2(3), MPEG1(7), MPL(4), PCNA(2), PLK1(3), PRKDC(40), PTPRA(7), PTTG1(2), RB1(23), RBL1(13), SKP2(4), SMAD4(3), TBC1D8(9), TGFB1(2), TP53(48), WEE1(1) 40479800 514 121 487 137 116 208 72 21 83 14 6.73e-14 3.60e-13 116 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 54 BAK1(3), BAX(3), BFAR(6), BTK(4), CAD(21), CASP10(8), CASP3(3), CASP8(12), CASP8AP2(3), CDK2AP1(1), CSNK1A1(4), DAXX(6), DEDD(1), DEDD2(2), DIABLO(2), EGFR(10), EPHB2(8), FAF1(6), FAIM2(2), IL8(3), MAP2K4(4), MAP3K1(24), MAP3K5(19), MAPK1(2), MAPK10(7), MAPK8(7), MAPK8IP1(4), MAPK9(4), MET(9), NFAT5(10), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), NR0B2(2), PFN1(1), PFN2(1), PTPN13(20), RALBP1(4), RIPK1(8), ROCK1(15), SMPD1(10), TP53(48), TPX2(10), TRAF2(2), TUFM(4) 25073792 348 105 326 86 80 137 39 16 70 6 1.16e-13 6.16e-13 117 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 220 ADCYAP1R1(5), ADORA1(3), ADORA2A(4), ADORA2B(1), ADORA3(3), ADRA1A(8), ADRA1B(5), ADRA2B(6), ADRB1(1), ADRB2(5), AGTR1(1), AGTR2(7), AVPR1A(7), AVPR1B(2), AVPR2(4), BDKRB1(2), BDKRB2(7), BRS3(14), C3AR1(7), C5AR1(3), CALCR(4), CALCRL(7), CCKAR(9), CCKBR(3), CGA(1), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), CNR1(6), CNR2(3), CRHR1(2), CRHR2(1), CTSG(3), CYSLTR1(6), CYSLTR2(3), DRD1(5), DRD2(6), DRD3(4), DRD5(8), EDNRA(5), F2(8), F2R(6), F2RL1(2), F2RL2(2), FPR1(1), FSHR(14), GABBR1(8), GABBR2(13), GABRA1(8), GABRA2(10), GABRA3(12), GABRA4(12), GABRA5(6), GABRA6(6), GABRB1(7), GABRB2(12), GABRB3(9), GABRE(5), GABRG1(6), GABRG2(14), GABRG3(7), GABRP(3), GABRQ(5), GABRR1(3), GALR1(2), GALR3(2), GH1(2), GH2(2), GHR(8), GHRHR(1), GHSR(7), GIPR(3), GLP1R(5), GLP2R(8), GLRA1(6), GLRA2(6), GLRA3(8), GLRB(6), GNRHR(3), GPR156(4), GPR50(4), GPR63(4), GPR83(2), GRIA1(11), GRIA2(17), GRIA3(18), GRIA4(15), GRID1(7), GRID2(9), GRIK1(10), GRIK2(10), GRIK3(13), GRIK4(3), GRIK5(15), GRIN1(3), GRIN2A(18), GRIN2B(18), GRIN2C(5), GRIN2D(5), GRIN3A(12), GRM1(18), GRM2(5), GRM3(14), GRM4(12), GRM5(19), GRM6(9), GRM7(10), GRM8(17), GRPR(3), GZMA(6), HCRTR2(6), HRH1(9), HRH2(3), HRH4(4), HTR1A(11), HTR1B(4), HTR1D(5), HTR1E(5), HTR1F(10), HTR2A(9), HTR2B(2), HTR2C(13), HTR4(5), HTR5A(7), HTR6(3), HTR7(3), LEP(1), LEPR(10), LHB(2), LHCGR(14), LTB4R(2), LTB4R2(3), MAS1(1), MC2R(1), MC3R(5), MC4R(3), MC5R(8), MCHR1(7), MCHR2(1), MLNR(2), MTNR1A(4), MTNR1B(3), NMBR(3), NMUR1(4), NMUR2(6), NPFFR1(2), NPFFR2(9), NPY1R(3), NPY2R(3), NPY5R(7), NR3C1(11), NTSR1(4), NTSR2(1), OPRK1(6), OPRM1(8), OXTR(4), P2RX1(4), P2RX3(7), P2RX4(1), P2RX5(5), P2RX7(1), P2RY1(2), P2RY10(5), P2RY11(8), P2RY13(1), P2RY14(3), P2RY2(3), P2RY4(5), P2RY6(3), PARD3(19), PPYR1(6), PRL(4), PRLHR(1), PRLR(3), PRSS1(4), PRSS3(2), PTAFR(4), PTGDR(6), PTGER2(2), PTGER3(7), PTGER4(7), PTGFR(9), PTGIR(2), PTH2R(8), RXFP1(15), RXFP2(11), SCTR(3), SSTR1(9), SSTR2(2), SSTR3(3), SSTR4(10), TAAR1(6), TAAR2(4), TAAR5(5), TAAR6(4), TAAR8(2), TAAR9(6), TACR1(5), TACR2(2), TACR3(8), THRA(4), THRB(2), TRHR(2), TRPV1(3), TSHB(3), TSHR(7), VIPR1(2) 75986456 1253 151 1211 448 376 522 188 52 113 2 6.69e-10 3.52e-09 118 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(18), ANAPC10(1), ANAPC2(5), ANAPC4(5), ANAPC5(7), ANAPC7(3), BTRC(11), CDC16(1), CDC20(4), CDC23(3), CDC27(13), CUL1(12), CUL2(8), CUL3(13), FBXW11(4), FBXW7(32), ITCH(7), RBX1(1), SKP2(4), SMURF1(9), SMURF2(5), TCEB1(2), UBA1(14), UBE2C(1), UBE2D2(2), UBE2D3(2), UBE2E1(2), UBE2E2(2), UBE2E3(6), VHL(2), WWP1(12), WWP2(4) 14513704 215 78 205 45 45 89 29 18 32 2 2.87e-08 1.50e-07 119 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 163 ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY7(5), ADCY8(15), ADCY9(17), ADORA2A(4), ADORA2B(1), ADRA1A(8), ADRA1B(5), ADRB1(1), ADRB2(5), AGTR1(1), ATP2A1(9), ATP2A2(6), ATP2A3(9), ATP2B1(14), ATP2B2(8), ATP2B3(14), ATP2B4(13), AVPR1A(7), AVPR1B(2), BDKRB1(2), BDKRB2(7), BST1(1), CACNA1A(15), CACNA1C(21), CACNA1D(23), CACNA1E(40), CACNA1F(30), CACNA1G(16), CACNA1I(5), CACNA1S(22), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), CCKAR(9), CCKBR(3), CD38(5), CHRM1(3), CHRM2(8), CHRM3(6), CHRM5(8), CHRNA7(4), CYSLTR1(6), CYSLTR2(3), DRD1(5), EDNRA(5), EGFR(10), ERBB2(3), ERBB3(14), ERBB4(19), F2R(6), GNA11(2), GNA14(5), GNA15(1), GNAL(6), GNAS(16), GRIN1(3), GRIN2A(18), GRIN2C(5), GRIN2D(5), GRM1(18), GRM5(19), GRPR(3), HRH1(9), HRH2(3), HTR2A(9), HTR2B(2), HTR2C(13), HTR4(5), HTR5A(7), HTR6(3), HTR7(3), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), LHCGR(14), LTB4R2(3), MYLK(10), MYLK2(6), NOS1(14), NOS3(6), NTSR1(4), OXTR(4), P2RX1(4), P2RX3(7), P2RX4(1), P2RX5(5), P2RX7(1), PDE1A(10), PDE1B(6), PDE1C(10), PDGFRA(19), PDGFRB(10), PHKA1(13), PHKA2(12), PHKB(10), PHKG1(5), PHKG2(2), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(3), PLCD4(10), PLCE1(31), PLCG1(8), PLCG2(23), PLCZ1(11), PLN(1), PPID(2), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), PTAFR(4), PTGER3(7), PTGFR(9), PTK2B(13), RYR1(59), RYR2(89), RYR3(65), SLC25A4(2), SLC25A5(1), SLC25A6(4), SLC8A1(9), SLC8A2(3), SLC8A3(9), SPHK1(2), SPHK2(1), TACR1(5), TACR2(2), TACR3(8), TNNC1(2), TNNC2(3), TRHR(2), TRPC1(12), VDAC1(2), VDAC2(1), VDAC3(2) 95398904 1385 151 1348 515 397 563 192 69 149 15 4.30e-08 2.22e-07 120 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 BRAF(9), CPEB1(7), EGFR(10), ERBB2(3), ERBB4(19), ETS1(4), ETS2(5), ETV6(5), ETV7(3), FMN2(18), GRB2(3), KRAS(27), MAP2K1(2), MAPK1(2), MAPK3(3), NOTCH2(9), NOTCH3(20), NOTCH4(10), PIWIL1(13), PIWIL2(13), PIWIL3(7), PIWIL4(9), RAF1(5), SOS1(10), SOS2(16), SPIRE1(6) 16813656 238 85 207 41 66 88 45 12 25 2 7.70e-08 3.95e-07 121 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(8), BRAF(9), CACNA1A(15), CRHR1(2), GNA11(2), GNA12(7), GNA13(7), GNAI1(4), GNAI2(4), GNAI3(3), GNAO1(4), GNAS(16), GNAZ(4), GRIA1(11), GRIA2(17), GRIA3(18), GRID2(9), GRM1(18), GRM5(19), GUCY1A2(9), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(6), GUCY2F(21), IGF1(2), IGF1R(10), ITPR1(23), ITPR2(25), ITPR3(15), KRAS(27), LYN(6), MAP2K1(2), MAPK1(2), MAPK3(3), NOS1(14), NOS3(6), NPR1(10), NPR2(10), NRAS(8), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PPP2CA(4), PPP2CB(2), PPP2R1A(30), PPP2R1B(5), PPP2R2A(10), PPP2R2B(7), PPP2R2C(2), PRKCA(7), PRKCG(6), PRKG1(4), PRKG2(8), RAF1(5), RYR1(59) 39391328 616 123 566 192 168 251 102 28 63 4 1.02e-07 5.19e-07 122 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 135 ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ADRA1A(8), ADRA1B(5), ADRB1(1), ADRB2(5), ANXA6(8), ARRB1(4), ARRB2(3), ATP1A4(19), ATP1B1(3), ATP1B2(4), ATP1B3(2), ATP2A2(6), ATP2A3(9), ATP2B1(14), ATP2B2(8), ATP2B3(14), CACNA1A(15), CACNA1C(21), CACNA1D(23), CACNA1E(40), CACNA1S(22), CACNB1(7), CACNB3(4), CALM2(3), CALR(1), CAMK1(2), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), CASQ1(4), CASQ2(6), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), GJA1(5), GJA4(1), GJB1(1), GJB2(2), GJB3(2), GJB4(3), GJB5(2), GJB6(3), GNA11(2), GNAI2(4), GNAI3(3), GNAO1(4), GNAZ(4), GNB1(1), GNB2(6), GNB4(3), GNB5(1), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GRK4(9), GRK5(8), GRK6(2), ITPR1(23), ITPR2(25), ITPR3(15), KCNB1(11), KCNJ3(9), KCNJ5(5), MIB1(6), MYCBP(1), NME7(2), PEA15(2), PLCB3(9), PLN(1), PRKACA(4), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCQ(6), PRKCZ(3), PRKD1(6), RGS1(4), RGS10(2), RGS14(4), RGS16(3), RGS17(3), RGS18(2), RGS2(2), RGS20(1), RGS3(8), RGS4(6), RGS5(4), RGS6(6), RGS7(6), RGS9(10), RYR1(59), RYR2(89), RYR3(65), SLC8A1(9), SLC8A3(9), USP5(11), YWHAH(2), YWHAQ(1) 68189584 958 136 933 349 268 398 116 48 117 11 4.02e-07 2.03e-06 123 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(3), CCNB1(7), CCND1(12), CCND2(7), CCND3(3), CCNH(3), CDC25A(7), CDK2(2), CDK4(3), CDK6(3), CDK7(4), CDKN1A(1), CDKN1B(6), CDKN2A(1), CDKN2C(2), CDKN2D(1), E2F1(6), RB1(23), RBL1(13) 5580744 107 46 103 19 18 40 15 7 23 4 7.88e-07 3.94e-06 124 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 84 ACVR1(9), ACVR1B(5), ACVR1C(3), ACVR2A(5), ACVR2B(5), ACVRL1(1), AMHR2(2), BMP2(5), BMP4(7), BMP5(12), BMP6(4), BMP7(10), BMP8A(3), BMP8B(1), BMPR1A(4), BMPR1B(6), BMPR2(9), CHRD(8), COMP(3), CREBBP(24), CUL1(12), DCN(7), E2F4(2), EP300(23), FST(4), GDF5(7), GDF6(3), ID1(2), ID2(1), IFNG(5), INHBA(3), INHBB(2), INHBC(1), INHBE(4), LEFTY1(3), LEFTY2(1), LTBP1(15), MAPK1(2), MAPK3(3), MYC(6), NODAL(2), NOG(2), PITX2(9), PPP2CA(4), PPP2CB(2), PPP2R1A(30), PPP2R1B(5), PPP2R2A(10), PPP2R2B(7), PPP2R2C(2), RBL1(13), RBL2(15), RBX1(1), RHOA(3), ROCK1(15), ROCK2(10), RPS6KB1(2), RPS6KB2(4), SMAD1(1), SMAD2(7), SMAD3(5), SMAD4(3), SMAD5(8), SMAD7(2), SMAD9(1), SMURF1(9), SMURF2(5), SP1(6), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), THBS1(9), THBS2(17), THBS3(2), THBS4(6), ZFYVE16(18), ZFYVE9(15) 34539456 506 108 479 135 140 194 65 33 67 7 2.02e-06 0.000010 125 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(14), CARM1(4), CCND1(12), CREBBP(24), EP300(23), ERCC3(8), ESR1(10), GRIP1(11), GTF2A1(3), GTF2E1(3), GTF2F1(5), HDAC1(3), HDAC2(4), HDAC3(8), HDAC4(12), HDAC5(10), HDAC6(12), MEF2C(8), NCOR2(16), NR0B1(6), NRIP1(14), PELP1(9), POLR2A(17), SRA1(1), TBP(3) 15693192 240 75 229 75 39 114 32 12 41 2 5.53e-06 0.000027 126 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 91 ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ATF4(3), CACNA1C(21), CACNA1D(23), CACNA1F(30), CACNA1S(22), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CDC42(4), CGA(1), EGFR(10), ELK1(2), GNA11(2), GNAS(16), GNRH1(1), GNRH2(1), GNRHR(3), GRB2(3), HBEGF(2), ITPR1(23), ITPR2(25), ITPR3(15), JUN(1), KRAS(27), LHB(2), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K2(8), MAP3K3(6), MAP3K4(16), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK7(11), MAPK8(7), MAPK9(4), MMP14(3), MMP2(6), NRAS(8), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLD1(9), PLD2(7), PRKACA(4), PRKACG(7), PRKCA(7), PRKCD(4), PRKX(2), PTK2B(13), RAF1(5), SOS1(10), SOS2(16), SRC(2) 45180888 630 120 592 195 183 247 87 29 72 12 9.74e-06 0.000048 127 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 37 ADAM17(8), CREBBP(24), CTBP2(5), DLL1(6), DLL3(5), DLL4(2), DTX1(5), DTX2(2), DTX3(4), DTX3L(4), DTX4(4), DVL2(5), DVL3(7), EP300(23), HDAC1(3), HDAC2(4), HES1(1), JAG1(13), MAML1(6), MAML2(5), MAML3(14), MFNG(3), NCOR2(16), NCSTN(7), NOTCH2(9), NOTCH3(20), NOTCH4(10), NUMB(7), NUMBL(3), PSEN1(5), PSEN2(3), RBPJ(4), RBPJL(7), SNW1(5) 20548784 249 80 243 77 59 106 26 12 42 4 0.000014 0.000069 128 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 49 ACTG1(1), APAF1(11), ARHGDIB(1), BAG4(3), BID(2), BIRC2(10), BIRC3(2), CASP2(4), CASP3(3), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CFLAR(5), CHUK(7), CRADD(2), CYCS(2), DAXX(6), DFFB(3), GSN(4), LMNA(5), LMNB1(4), MAP3K1(24), MAP3K14(4), MAP3K5(19), MAPK8(7), MDM2(3), NFKB1(7), NFKBIA(2), NUMA1(17), PAK2(3), PRKCD(4), PRKDC(40), PSEN1(5), PSEN2(3), PTK2(8), RASA1(23), RB1(23), RELA(4), RIPK1(8), SPTAN1(23), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(2) 24767264 335 83 326 92 85 117 46 19 62 6 0.000023 0.00011 129 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 122 ABL1(5), ABLIM1(6), ABLIM2(4), ABLIM3(5), ARHGEF12(19), CDC42(4), CDK5(1), CFL1(1), CFL2(7), CXCL12(2), CXCR4(1), DCC(24), DPYSL2(9), DPYSL5(4), EFNA1(1), EFNA3(1), EFNA4(3), EFNA5(1), EFNB1(4), EFNB3(1), EPHA1(8), EPHA2(3), EPHA3(11), EPHA4(14), EPHA5(20), EPHA6(17), EPHA7(8), EPHA8(9), EPHB1(19), EPHB2(8), EPHB3(2), EPHB4(3), EPHB6(7), FES(14), FYN(6), GNAI1(4), GNAI2(4), GNAI3(3), GSK3B(8), ITGB1(5), KRAS(27), L1CAM(13), LIMK1(6), LIMK2(10), LRRC4C(9), MAPK1(2), MAPK3(3), MET(9), NCK1(4), NCK2(7), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NGEF(10), NRAS(8), NRP1(11), NTN1(3), NTN4(4), NTNG1(8), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PLXNA1(20), PLXNA2(21), PLXNA3(14), PLXNB1(10), PLXNC1(23), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PTK2(8), RAC1(1), RAC2(2), RASA1(23), RGS3(8), RHOA(3), RND1(5), ROBO1(17), ROBO2(15), ROBO3(9), ROCK1(15), ROCK2(10), SEMA3A(6), SEMA3B(4), SEMA3C(9), SEMA3D(8), SEMA3E(5), SEMA3F(5), SEMA3G(3), SEMA4A(4), SEMA4B(3), SEMA4C(7), SEMA4D(6), SEMA4F(10), SEMA4G(3), SEMA5A(15), SEMA5B(6), SEMA6A(7), SEMA6C(2), SEMA6D(16), SEMA7A(9), SLIT1(10), SLIT2(22), SLIT3(18), SRGAP1(15), SRGAP2(9), SRGAP3(7), UNC5A(8), UNC5B(5), UNC5C(7), UNC5D(11) 66634624 926 130 873 295 260 343 144 41 132 6 0.000068 0.00033 130 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(3), CCNA2(2), CCND1(12), CCNE2(5), CDK2(2), CDK4(3), CDKN1B(6), CDKN2A(1), E2F1(6), E2F2(2), E2F4(2), PRB1(2) 2975504 46 32 45 10 5 15 10 5 11 0 0.00010 0.00048 131 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(3), CSF1R(6), DDX20(4), E2F1(6), E2F4(2), ETS1(4), ETS2(5), ETV3(10), FOS(2), HDAC2(4), HDAC5(10), JUN(1), NCOR2(16), RBL1(13), RBL2(15), SIN3A(24), SIN3B(11) 8338256 136 54 129 28 27 51 18 13 24 3 0.00010 0.00048 132 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(24), EP300(23), ESR1(10), MAPK1(2), MAPK3(3), PELP1(9), SRC(2) 5108800 73 41 70 18 12 28 12 5 16 0 0.00012 0.00056 133 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDK2(2), CDKN1B(6), CUL1(12), E2F1(6), RB1(23), RBX1(1), SKP2(4) 3109920 54 30 53 8 8 21 10 2 9 4 0.00015 0.00069 134 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 9 ALDOA(4), CTSD(3), ESR1(10), GREB1(14), HSPB2(1), MTA1(4), MTA3(4), PDZK1(3), TUBA8(7) 3541440 50 33 49 13 11 22 6 6 5 0 0.00059 0.0027 135 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 148 ADORA1(3), ADORA2A(4), ADORA2B(1), ADORA3(3), ADRA1A(8), ADRA1B(5), ADRB1(1), ADRB2(5), AGTR1(1), AGTR2(7), AVPR1A(7), AVPR1B(2), AVPR2(4), BDKRB1(2), BDKRB2(7), BRS3(14), C3AR1(7), CCBP2(3), CCKAR(9), CCKBR(3), CCR1(3), CCR2(4), CCR3(4), CCR4(2), CCR6(5), CCR7(6), CCR8(5), CCR9(1), CCRL1(4), CHML(5), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), CMKLR1(8), CNR1(6), CNR2(3), CX3CR1(4), CXCR3(5), CXCR4(1), DRD1(5), DRD2(6), DRD3(4), DRD5(8), EDNRA(5), F2R(6), F2RL1(2), F2RL2(2), FPR1(1), FSHR(14), GALR1(2), GALR3(2), GALT(2), GHSR(7), GNB2L1(1), GPR17(3), GPR174(9), GPR3(5), GPR37(7), GPR37L1(4), GPR4(8), GPR50(4), GPR6(4), GPR63(4), GPR77(1), GPR83(2), GPR85(4), GPR87(5), GRPR(3), HCRTR2(6), HRH1(9), HRH2(3), HTR1A(11), HTR1B(4), HTR1D(5), HTR1E(5), HTR1F(10), HTR2A(9), HTR2B(2), HTR2C(13), HTR4(5), HTR5A(7), HTR6(3), HTR7(3), LHCGR(14), LTB4R(2), MAS1(1), MC3R(5), MC4R(3), MC5R(8), MLNR(2), MTNR1A(4), MTNR1B(3), NMBR(3), NMUR1(4), NMUR2(6), NPY1R(3), NPY2R(3), NPY5R(7), NTSR1(4), NTSR2(1), OPN1SW(6), OPN3(1), OPRK1(6), OPRM1(8), OR10A5(3), OR12D3(6), OR1F1(3), OR1Q1(3), OR2H1(1), OR5V1(7), OR7A5(4), OR7C1(6), OR8B8(3), OXTR(4), P2RY1(2), P2RY10(5), P2RY11(8), P2RY12(2), P2RY13(1), P2RY14(3), P2RY2(3), P2RY6(3), PPYR1(6), PTAFR(4), PTGDR(6), PTGER2(2), PTGER4(7), PTGFR(9), PTGIR(2), RGR(5), RHO(3), RRH(2), SSTR1(9), SSTR2(2), SSTR3(3), SSTR4(10), SUCNR1(1), TRHR(2) 40485752 652 107 634 230 191 291 87 29 54 0 0.00063 0.0029 136 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 37 ATF2(6), CDC42(4), CREB1(5), DAXX(6), DDIT3(1), ELK1(2), GRB2(3), HMGN1(1), HSPB2(1), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K5(19), MAP3K7(8), MAP3K9(3), MAPK14(4), MAPKAPK2(4), MAPKAPK5(4), MAX(4), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), MKNK1(3), MYC(6), PLA2G4A(9), RAC1(1), RIPK1(8), RPS6KA5(7), SHC1(5), STAT1(12), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TRAF2(2) 13175992 197 66 193 50 45 91 20 12 27 2 0.00072 0.0033 137 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), AKAP1(7), AKAP10(7), AKAP11(22), AKAP12(14), AKAP3(13), AKAP5(1), AKAP6(26), AKAP7(4), AKAP8(3), AKAP9(43), ARHGEF1(9), CALM2(3), CHMP1B(1), GNA11(2), GNA12(7), GNA13(7), GNA14(5), GNA15(1), GNAI2(4), GNAI3(3), GNAL(6), GNAO1(4), GNAZ(4), GNB1(1), GNB2(6), GNB5(1), GNG12(1), GNG13(2), GNG3(2), GNG4(5), GNGT2(2), ITPR1(23), KCNJ3(9), KRAS(27), NRAS(8), PALM2(5), PDE1A(10), PDE1B(6), PDE1C(10), PDE4A(9), PDE4B(12), PDE4C(2), PDE4D(7), PDE7B(5), PDE8A(5), PDE8B(15), PLCB3(9), PPP3CA(2), PPP3CC(4), PRKACA(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCI(6), PRKCQ(6), PRKCZ(3), PRKD1(6), PRKD3(9), RHOA(3), RRAS(1), SLC9A1(6), USP5(11) 41725752 583 108 546 198 166 206 99 33 72 7 0.00088 0.0040 138 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 9 CREB1(5), FOS(2), JUN(1), KEAP1(7), MAPK1(2), MAPK14(4), MAPK8(7), NFE2L2(12), PRKCA(7) 3004024 47 31 44 8 6 15 10 7 9 0 0.00091 0.0041 139 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(36), CDH1(12), CREBBP(24), EP300(23), MAP2K1(2), MAP3K7(8), MAPK3(3), SKIL(7), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6) 9292808 139 56 135 37 26 59 19 8 23 4 0.0010 0.0045 140 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 23 ATF1(4), CASP2(4), CHUK(7), CRADD(2), IKBKB(8), JUN(1), LTA(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K14(4), MAP4K2(6), MAPK14(4), MAPK8(7), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), TANK(2), TNFRSF1A(4), TRAF2(2) 8353136 119 47 118 29 19 46 17 14 21 2 0.0012 0.0052 141 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(3), CDK2(2), CUL1(12), E2F1(6), RB1(23), SKP2(4) 3030312 50 28 49 8 8 18 10 2 8 4 0.0013 0.0058 142 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(8), GABRA2(10), GABRA3(12), GABRA4(12), GABRA5(6), GABRA6(6), PRKCE(7), SOD1(2) 2907552 63 33 58 21 19 22 8 4 10 0 0.0017 0.0076 143 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 124 ALCAM(5), CADM1(2), CADM3(5), CD2(4), CD22(11), CD226(5), CD274(1), CD276(2), CD28(3), CD34(1), CD4(6), CD40(2), CD40LG(5), CD58(1), CD6(5), CD80(5), CD86(4), CD8A(2), CD8B(1), CD99(1), CDH1(12), CDH2(11), CDH3(5), CDH4(13), CDH5(3), CLDN1(2), CLDN10(7), CLDN11(1), CLDN15(4), CLDN16(4), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CNTN1(12), CNTN2(6), CNTNAP1(9), CNTNAP2(24), CTLA4(2), F11R(1), GLG1(4), HLA-A(1), HLA-B(4), HLA-C(1), HLA-DMA(3), HLA-DOA(2), HLA-DOB(2), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRB5(2), HLA-E(1), HLA-F(2), HLA-G(2), ICAM1(1), ICAM2(3), ICAM3(2), ICOS(2), ICOSLG(2), ITGA4(8), ITGA6(10), ITGA8(14), ITGA9(13), ITGAL(12), ITGAM(19), ITGAV(6), ITGB1(5), ITGB2(10), ITGB7(4), ITGB8(4), JAM2(7), JAM3(2), L1CAM(13), MAG(7), MPZ(1), MPZL1(2), NCAM1(7), NCAM2(30), NEGR1(3), NEO1(12), NFASC(27), NLGN1(6), NLGN2(4), NLGN3(18), NRCAM(10), NRXN1(25), NRXN2(16), NRXN3(21), OCLN(2), PTPRC(11), PTPRF(19), PTPRM(14), PVR(2), PVRL1(6), PVRL2(3), PVRL3(5), SDC1(1), SDC2(1), SDC3(1), SDC4(3), SELE(5), SELL(3), SELP(10), SELPLG(7), SIGLEC1(10), SPN(1), VCAM1(9), VCAN(45) 51960712 721 118 696 228 194 298 101 35 85 8 0.0021 0.0092 144 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 135 ACTA1(3), ACTA2(5), ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ADM(2), ARRB1(4), ARRB2(3), ATF1(4), ATF2(6), ATF3(3), ATF4(3), ATF5(5), ATP2A2(6), ATP2A3(9), CACNB3(4), CALCA(1), CALM2(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CNN1(2), CORIN(8), CRHR1(2), DGKZ(8), ETS2(5), FOS(2), GABPA(3), GABPB2(8), GBA2(9), GJA1(5), GNB1(1), GNB2(6), GNB4(3), GNB5(1), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GRK4(9), GRK5(8), GRK6(2), GSTO1(3), GUCA2B(1), GUCY1A3(9), IGFBP1(4), IGFBP2(4), IGFBP3(3), IGFBP6(1), IL1B(2), IL6(4), ITPR1(23), ITPR2(25), ITPR3(15), JUN(1), MIB1(6), MYL2(1), MYLK2(6), NFKB1(7), NOS1(14), NOS3(6), OXTR(4), PDE4B(12), PDE4D(7), PLCB3(9), PLCD1(5), PLCG1(8), PLCG2(23), PRKACA(4), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(7), PRKCH(7), PRKCQ(6), PRKCZ(3), PRKD1(6), RAMP1(1), RAMP3(2), RGS1(4), RGS10(2), RGS14(4), RGS16(3), RGS17(3), RGS18(2), RGS2(2), RGS20(1), RGS3(8), RGS4(6), RGS5(4), RGS6(6), RGS7(6), RGS9(10), RYR1(59), RYR2(89), RYR3(65), SLC8A1(9), SP1(6), TNXB(16), USP5(11), YWHAH(2), YWHAQ(1) 62451856 844 120 819 316 244 352 112 37 90 9 0.0026 0.011 145 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 26 ARHGDIB(1), BAG4(3), CASP2(4), CASP3(3), CASP8(12), CRADD(2), DFFB(3), JUN(1), LMNA(5), LMNB1(4), MADD(15), MAP2K4(4), MAP3K1(24), MAP3K7(8), MAPK8(7), PAK1(1), PAK2(3), PRKDC(40), RB1(23), RIPK1(8), SPTAN1(23), TNFRSF1A(4), TRAF2(2) 14067304 200 59 195 61 50 65 28 11 40 6 0.0027 0.012 146 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 26 CALM2(3), CRKL(4), GRB2(3), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP3K1(24), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(7), PAK1(1), PLCG1(8), PRKCA(7), PTK2B(13), RAC1(1), RAF1(5), SHC1(5), SOS1(10), SRC(2), SYT1(4) 9544280 120 54 116 39 32 42 15 13 16 2 0.0029 0.012 147 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(4) 5521472 83 40 81 21 15 38 7 4 19 0 0.0046 0.019 148 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(4) 5521472 83 40 81 21 15 38 7 4 19 0 0.0046 0.019 149 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(4) 5521472 83 40 81 21 15 38 7 4 19 0 0.0046 0.019 150 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(4), CD34(1), CD3D(3), CD3E(1), CD3G(1), CD4(6), CD58(1), CD8A(2), CSF3(1), IL6(4), IL8(3), KITLG(2) 2280856 29 24 29 7 4 13 4 0 8 0 0.0046 0.019 151 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(12), ADCY8(15), ARAF(8), ATF4(3), BRAF(9), CACNA1C(21), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), CREBBP(24), EP300(23), GRIA1(11), GRIA2(17), GRIN1(3), GRIN2A(18), GRIN2B(18), GRIN2C(5), GRIN2D(5), GRM1(18), GRM5(19), ITPR1(23), ITPR2(25), ITPR3(15), KRAS(27), MAP2K1(2), MAPK1(2), MAPK3(3), NRAS(8), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PPP1CA(3), PPP1CB(4), PPP1CC(2), PPP1R12A(8), PPP1R1A(3), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), RAF1(5), RAP1A(3), RAP1B(2), RAPGEF3(7), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA6(12) 36093920 510 103 475 168 128 197 101 18 64 2 0.0051 0.021 152 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), AKT1(3), BDKRB2(7), CALM2(3), CHRM1(3), CHRNA1(6), FLT1(15), FLT4(9), KDR(20), NOS3(6), PDE2A(11), PDE3A(14), PDE3B(9), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKG1(4), PRKG2(8), RYR2(89), SLC7A1(6), SYT1(4), TNNI1(1) 13895688 242 62 236 83 58 103 30 11 35 5 0.0057 0.023 153 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(4), CD28(3), CD3D(3), CD3E(1), CD3G(1), CD4(6), ICAM1(1), ITGAL(12), ITGB2(10), PTPRC(11), THY1(1) 4000984 53 33 53 18 11 25 6 1 10 0 0.0063 0.025 154 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 5 CD28(3), CD3D(3), CD3E(1), CD3G(1), CD4(6) 941904 14 14 14 5 1 7 1 0 5 0 0.0064 0.026 155 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 30 CHUK(7), IFNB1(2), IKBKB(8), IL1B(2), IL1R1(4), IL1RAP(5), IL6(4), IRAK1(4), IRAK2(5), IRAK3(7), JUN(1), MAP2K3(7), MAP2K6(6), MAP3K1(24), MAP3K14(4), MAP3K7(8), MAPK14(4), MAPK8(7), MYD88(1), NFKB1(7), NFKBIA(2), RELA(4), TGFB1(2), TGFB2(5), TGFB3(8), TRAF6(3) 10439560 141 52 138 32 29 54 22 11 23 2 0.0067 0.027 156 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(6), CD8A(2), CSF1(3), CSF3(1), EPO(1), IL2(2), IL5(1), IL6(4), IL7(1), IL8(3) 2205464 24 22 24 10 8 9 3 0 4 0 0.0072 0.029 157 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 55 ATP12A(13), ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), ATP7B(9), COX10(1), COX4I1(2), COX5A(1), COX5B(1), COX6A1(3), COX6B1(1), COX6C(2), COX7A1(2), COX7B(3), COX7C(2), COX8A(1), NDUFA1(1), NDUFA10(6), NDUFA4(1), NDUFA5(4), NDUFA8(5), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(2), PPA2(3), SDHA(10), SDHB(1), SHMT1(4), UQCRB(3), UQCRC1(2) 12514576 178 63 174 45 47 76 19 8 28 0 0.0077 0.030 158 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 42 CBL(8), CD28(3), CD3D(3), CSK(1), CTLA4(2), DAG1(4), EPHB2(8), FBXW7(32), GRB2(3), ITK(5), ITPKB(7), LCK(3), LCP2(4), MAPK1(2), NCK1(4), NFAT5(10), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PLCG1(8), PTPRC(11), RAF1(5), RASGRP1(6), RASGRP2(2), RASGRP3(5), RASGRP4(5), SOS1(10), SOS2(16), VAV1(10), ZAP70(6) 19522808 233 69 221 80 68 85 30 10 36 4 0.0090 0.035 159 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), FDXR(2), SHMT1(4) 5818576 85 40 83 21 15 38 9 4 19 0 0.0091 0.035 160 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 48 ADORA3(3), ALG6(3), CCKBR(3), CCR2(4), CCR3(4), CELSR2(18), CELSR3(18), CHRM2(8), CHRM3(6), CIDEB(2), CXCR3(5), EDNRA(5), EMR2(3), EMR3(3), F2R(6), FSHR(14), GHRHR(1), GNRHR(3), GPR116(15), GPR132(6), GPR133(11), GPR143(4), GPR17(3), GPR18(1), GPR55(2), GPR56(2), GPR61(2), GPR77(1), GPR84(3), GRM1(18), GRPR(3), HRH4(4), LGR6(13), LPHN2(19), LPHN3(14), LTB4R2(3), NTSR1(4), OR8G2(5), P2RY11(8), P2RY13(1), PTGFR(9), SMO(5), SSTR2(2), TAAR5(5), TSHR(7), VN1R1(4) 21046272 283 74 280 98 85 113 37 16 32 0 0.0099 0.038 161 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(3), BTK(4), CALM2(3), CD79B(2), ELK1(2), FOS(2), GRB2(3), JUN(1), LYN(6), MAP2K1(2), MAP3K1(24), MAPK14(4), MAPK3(3), MAPK8(7), NFATC2(9), NFATC3(9), NFATC4(7), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKCA(7), RAC1(1), RAF1(5), SHC1(5), SOS1(10), SYK(3), SYT1(4), VAV1(10) 13570808 155 61 150 48 51 43 23 14 22 2 0.0099 0.038 162 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 106 ADA(2), ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADK(1), ADSL(5), ADSS(6), AK2(2), AK5(5), ALLC(7), AMPD1(17), AMPD2(6), AMPD3(4), ATIC(6), ATP1B1(3), ATP5A1(7), ATP5B(3), ATP5C1(1), ATP5F1(4), ATP5G1(2), ATP5G2(1), ATP5I(1), ATP5J(3), CANT1(1), DCK(4), ENPP1(8), ENPP3(14), ENTPD1(2), FHIT(2), GART(6), GDA(3), GMPS(11), GUCY1A2(9), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(6), GUCY2F(21), GUK1(6), HPRT1(2), IMPDH1(5), IMPDH2(3), NPR1(10), NPR2(10), NT5C(1), NT5E(5), NT5M(3), NUDT2(2), PAICS(3), PAPSS1(5), PAPSS2(5), PDE1A(10), PDE4A(9), PDE4B(12), PDE4C(2), PDE4D(7), PDE5A(11), PDE6B(5), PDE6C(10), PDE7B(5), PDE8A(5), PDE9A(8), PFAS(8), PKLR(5), PKM2(4), POLB(3), POLD1(11), POLD2(5), POLG(5), POLL(6), POLQ(18), POLR1B(10), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), PPAT(7), PRPS1(3), PRPS1L1(2), PRPS2(6), PRUNE(3), RRM1(2), RRM2(5) 44584696 564 100 555 172 144 236 75 33 76 0 0.010 0.038 163 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 38 ALK(13), AR(4), ESR1(10), ESR2(4), ESRRA(2), HNF4A(5), NPM1(2), NR0B1(6), NR1D1(3), NR1D2(1), NR1H2(2), NR1H3(4), NR1I2(2), NR1I3(5), NR2C2(5), NR2E1(5), NR2F1(5), NR2F2(5), NR3C1(11), NR4A1(4), NR4A2(6), NR5A2(10), PGR(10), PPARD(3), PPARG(5), RARA(1), RARB(4), RARG(2), ROR1(4), RORA(8), RORC(8), RXRA(1), RXRG(6), THRA(4), THRB(2), VDR(7) 14590088 179 62 171 55 51 75 27 11 15 0 0.010 0.039 164 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 21 CHUK(7), CREBBP(24), DUSP1(2), EP300(23), IKBKB(8), IL1B(2), IL8(3), MAP2K3(7), MAP2K6(6), MAP3K14(4), MAP3K7(8), MAPK14(4), MYD88(1), NFKB1(7), NFKBIA(2), NR3C1(11), RELA(4), TGFBR1(3), TGFBR2(6), TLR2(11) 10374088 143 52 140 45 28 54 26 9 26 0 0.011 0.043 165 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 9 ESR1(10), ESR2(4), PDE1A(10), PDE1B(6), PLCB1(4), PLCB2(7), PRL(4), VIP(1) 3849952 46 32 45 20 12 16 9 4 5 0 0.011 0.043 166 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 65 FAU(1), MRPS7(3), RPL10A(1), RPL10L(7), RPL11(1), RPL14(7), RPL18(4), RPL18A(2), RPL19(2), RPL21(2), RPL22L1(3), RPL23A(4), RPL24(2), RPL27(1), RPL27A(3), RPL28(2), RPL29(2), RPL3(1), RPL35A(2), RPL36AL(1), RPL37(3), RPL38(1), RPL39(3), RPL3L(3), RPL6(2), RPL8(1), RPL9(1), RPS10(1), RPS12(2), RPS13(1), RPS15A(1), RPS18(3), RPS20(3), RPS21(1), RPS24(2), RPS25(1), RPS27(1), RPS29(2), RPS3(2), RPS3A(1), RPS6(6), RPS7(3), RPS8(2), RPS9(1) 7791416 98 45 89 29 17 46 18 3 14 0 0.012 0.043 167 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(7), AGTR1(1), ATF2(6), CALM2(3), EGFR(10), ELK1(2), GRB2(3), JUN(1), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK1(2), MAPK3(3), MAPK8(7), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), PAK1(1), PRKCA(7), PTK2(8), PTK2B(13), RAC1(1), RAF1(5), SHC1(5), SOS1(10), SRC(2), SYT1(4) 11993776 148 58 144 45 36 55 18 13 24 2 0.012 0.044 168 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(6), NFYB(2), NFYC(1), RB1(23), SP1(6), SP3(8) 2476032 46 24 44 9 7 16 10 1 8 4 0.012 0.045 169 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 63 AGTR1(1), AGTR2(7), ATP8A1(13), AVPR1A(7), AVPR1B(2), AVPR2(4), BDKRB1(2), BDKRB2(7), BRS3(14), C3AR1(7), CCKAR(9), CCKBR(3), CCR1(3), CCR2(4), CCR3(4), CCR4(2), CCR6(5), CCR7(6), CCR8(5), CX3CR1(4), CXCR3(5), CXCR4(1), CXCR6(1), EDNRA(5), FPR1(1), FSHR(14), GALR1(2), GALR3(2), GALT(2), GHSR(7), GNB2L1(1), GNRHR(3), GPR77(1), GRPR(3), LHCGR(14), MC2R(1), MC3R(5), MC4R(3), MC5R(8), NMBR(3), NPY1R(3), NPY2R(3), NPY5R(7), NTSR1(4), NTSR2(1), OPRK1(6), OPRM1(8), OXTR(4), PPYR1(6), SSTR1(9), SSTR2(2), SSTR3(3), SSTR4(10), TACR1(5), TACR2(2), TACR3(8), TRHR(2), TSHR(7) 17648176 281 70 276 103 71 135 29 11 35 0 0.012 0.045 170 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(3), AKT2(4), AKT3(7), ASAH1(6), BRAF(9), DAG1(4), DRD2(6), EGFR(10), EPHB2(8), GRB2(3), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), KCNJ3(9), KCNJ5(5), KCNJ9(4), MAPK1(2), PI3(2), PIK3CB(13), PITX2(9), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), RAF1(5), RGS20(1), SHC1(5), SOS1(10), SOS2(16), SRC(2), STAT3(8), TERF2IP(2) 21195568 259 73 250 97 61 106 41 13 34 4 0.013 0.046 171 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 89 CD2BP2(2), CDC40(7), CLK2(7), CLK3(4), CLK4(5), COL2A1(10), CPSF1(7), CPSF2(10), CPSF3(6), CPSF4(1), CSTF1(3), CSTF2(10), CSTF2T(4), CSTF3(9), DDIT3(1), DDX1(3), DDX20(4), DHX15(6), DHX16(9), DHX38(6), DHX8(6), DHX9(11), DICER1(27), DNAJC8(1), FUS(2), GIPC1(1), METTL3(5), NCBP1(8), NCBP2(2), NONO(11), NXF1(3), PABPN1(1), PAPOLA(9), PHF5A(1), POLR2A(17), PPM1G(6), PRPF18(4), PRPF3(8), PRPF4(4), PRPF4B(15), PRPF8(17), PSKH1(6), PTBP1(1), PTBP2(6), RBM17(4), RBM5(4), RNGTT(8), RNMT(6), SF3A1(3), SF3A3(5), SF3B1(15), SF3B2(7), SF3B4(3), SF3B5(2), SNRPA(2), SNRPB(2), SNRPB2(1), SNRPD1(1), SNRPD2(1), SNRPD3(2), SNRPE(1), SNRPG(1), SPOP(19), SRPK1(10), SRPK2(5), SRRM1(8), SUPT5H(15), U2AF1(3), U2AF2(5), XRN2(13) 37685832 432 99 415 123 128 155 63 33 53 0 0.013 0.049 172 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 30 CD14(2), CHUK(7), ELK1(2), FOS(2), IKBKB(8), IRAK1(4), JUN(1), LY96(3), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K14(4), MAP3K7(8), MAPK14(4), MAPK8(7), MYD88(1), NFKB1(7), NFKBIA(2), RELA(4), TIRAP(2), TLR10(18), TLR2(11), TLR3(5), TLR4(13), TLR6(9), TLR7(12), TLR9(5), TRAF6(3) 12986768 185 59 183 42 44 63 31 16 27 4 0.014 0.051 173 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(24), EP300(23), LPL(9), NCOA1(15), NCOA2(13), PPARG(5), RXRA(1) 6593576 90 44 88 23 18 32 15 7 18 0 0.014 0.051 174 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(32), ASH2L(9), C17orf79(2), CARM1(4), CTCFL(11), DOT1L(5), EED(6), EHMT2(1), EZH1(8), EZH2(9), FBXO11(5), HCFC1(21), HSF4(2), JMJD4(2), JMJD6(4), KDM6A(10), MEN1(5), MLL(25), MLL2(38), MLL3(44), MLL4(40), MLL5(20), NSD1(25), OGT(13), PPP1CA(3), PPP1CB(4), PPP1CC(2), PRDM2(14), PRDM9(23), PRMT1(2), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), RBBP5(7), SATB1(14), SETD1A(9), SETD2(26), SETD7(5), SETD8(3), SETDB1(14), SETDB2(11), SETMAR(5), SMYD3(4), STK38(7), SUV39H1(7), SUV39H2(2), SUV420H1(11), SUZ12(5), WHSC1(15), WHSC1L1(16) 42288712 570 100 556 144 130 221 88 25 98 8 0.015 0.052 175 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B4GALT5(2), C1GALT1(2), C1GALT1C1(4), GALNT1(8), GALNT10(4), GALNT11(12), GALNT12(2), GALNT13(14), GALNT14(4), GALNT2(5), GALNT3(6), GALNT4(7), GALNT5(5), GALNT6(1), GALNT7(9), GALNT8(9), GALNTL1(7), GALNTL2(11), GALNTL4(4), GALNTL5(9), GCNT1(3), GCNT3(3), OGT(13), ST3GAL1(1), ST3GAL2(3), ST6GALNAC1(2), WBSCR17(11) 11595240 161 58 154 60 37 59 27 12 26 0 0.015 0.052 176 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 27 ADRA1A(8), ADRA1B(5), ADRB1(1), ADRB2(5), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), DRD1(5), DRD2(6), DRD3(4), DRD5(8), HRH1(9), HRH2(3), HTR1A(11), HTR1B(4), HTR1D(5), HTR1E(5), HTR1F(10), HTR2A(9), HTR2B(2), HTR2C(13), HTR4(5), HTR5A(7), HTR6(3), HTR7(3) 8312960 162 51 155 51 56 64 25 8 9 0 0.015 0.053 177 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 BAD(2), BAX(3), CASP8(12), CYCS(2), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK1(2), MAPK3(3), MAPK8(7), NFKB1(7), NSMAF(7), RAF1(5), RELA(4), RIPK1(8), SMPD1(10), TNFRSF1A(4), TRAF2(2) 7292936 108 43 105 22 23 36 18 5 24 2 0.016 0.055 178 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(8), EGF(17), EGFR(10), GRB2(3), MAP2K1(2), MAPK1(2), MAPK3(3), PTPRB(19), RAF1(5), RASA1(23), SHC1(5), SOS1(10), SPRY1(3), SPRY2(4), SPRY4(1), SRC(2) 9088704 117 51 113 28 23 44 25 6 19 0 0.017 0.060 179 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 27 CD4(6), CSF1(3), CSF3(1), IFNB1(2), IFNG(5), IL10(2), IL12A(5), IL12B(2), IL15(1), IL2(2), IL5(1), IL6(4), IL7(1), IL8(3), LTA(2), TGFB1(2), TGFB2(5), TGFB3(8) 4784416 55 36 54 20 13 28 8 1 5 0 0.017 0.060 180 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(4), CREB1(5), CREBBP(24), EP300(23), NCOA3(8), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RARA(1), RXRA(1) 7226968 87 44 84 27 18 34 10 6 19 0 0.019 0.066 181 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(5), CYP2A13(6), CYP2A6(10), CYP2A7(4), NAT1(7), NAT2(3), XDH(9) 2971784 44 30 41 15 17 19 4 1 3 0 0.019 0.066 182 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 33 AKT1(3), AKT2(4), AKT3(7), ARHGEF11(18), CDC42(4), DLG4(10), GNA13(7), LPA(11), MAP2K4(4), MAP3K1(24), MAP3K5(19), MAPK8(7), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PDK1(2), PHKA2(12), PI3(2), PIK3CB(13), PLD1(9), PLD2(7), PLD3(2), PTK2(8), RDX(11), ROCK1(15), ROCK2(10), SERPINA4(4), SRF(2) 17428200 240 66 232 66 53 97 28 15 41 6 0.021 0.072 183 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 20 AARS(6), ABAT(9), ADSL(5), ADSS(6), AGXT(3), AGXT2(8), ASL(2), ASNS(5), ASPA(4), CAD(21), CRAT(2), DARS(4), DDO(6), GAD1(6), GAD2(10), GOT1(5), GOT2(3), GPT2(4), NARS(7), PC(9) 8972888 125 51 123 42 31 52 18 6 18 0 0.022 0.074 184 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(3), APC(36), ASAH1(6), DAG1(4), DLG4(10), EPHB2(8), GNAI1(4), ITPR1(23), ITPR2(25), ITPR3(15), KCNJ3(9), KCNJ5(5), KCNJ9(4), MAPK1(2), PITX2(9), PTX3(1), RAC1(1), RHO(3), RYR1(59) 16874416 228 70 220 93 64 99 28 7 24 6 0.025 0.084 185 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 89 ACTB(3), BAD(2), CABIN1(11), CALM2(3), CAMK2B(1), CAMK4(3), CD3E(1), CD3G(1), CD69(1), CDKN1A(1), CNR1(6), CREBBP(24), CSNK2A1(7), CTLA4(2), EGR2(4), EGR3(5), EP300(23), FCER1A(7), FCGR3A(1), FKBP1B(1), FOS(2), FOSL1(3), GATA3(2), GATA4(1), GSK3A(8), GSK3B(8), ICOS(2), IFNB1(2), IFNG(5), IL10(2), IL1B(2), IL2(2), IL2RA(2), IL6(4), IL8(3), ITK(5), KPNA5(6), MAPK14(4), MAPK8(7), MAPK9(4), MEF2A(3), MEF2B(1), MEF2D(5), MYF5(4), NCK2(7), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NFKB2(9), NFKBIE(5), NPPB(2), NUP214(13), P2RX7(1), PAK1(1), PPIA(1), PPP3CB(5), PPP3CC(4), PTPRC(11), RELA(4), SLA(5), SP1(6), SP3(8), TGFB1(2), TRAF2(2), TRPV6(9), VAV1(10), VAV2(3), VAV3(9), XPO5(7) 31985056 353 85 344 121 88 142 51 18 54 0 0.025 0.084 186 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), IL6(4), IL6R(7), IL6ST(6), JAK1(16), JAK2(14), JAK3(5), JUN(1), MAP2K1(2), MAPK3(3), PTPN11(5), RAF1(5), SHC1(5), SOS1(10), SRF(2), STAT3(8) 8542856 107 47 104 26 23 39 18 9 14 4 0.025 0.084 187 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 14 CHUK(7), CREBBP(24), EP300(23), HDAC3(8), IKBKB(8), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), TNFRSF1A(4), TNFRSF1B(1), TRAF6(3) 7868544 99 42 95 29 14 43 16 3 23 0 0.027 0.089 188 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 138 ADA(2), ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ADK(1), ADSL(5), ADSS(6), ADSSL1(5), AK2(2), AK5(5), AK7(10), ALLC(7), AMPD1(17), AMPD2(6), AMPD3(4), ATIC(6), CANT1(1), DCK(4), ENPP1(8), ENPP3(14), ENTPD1(2), ENTPD3(4), ENTPD5(2), ENTPD6(8), FHIT(2), GART(6), GDA(3), GMPR(6), GMPR2(2), GMPS(11), GUCY1A2(9), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(6), GUCY2F(21), GUK1(6), HPRT1(2), IMPDH1(5), IMPDH2(3), NME7(2), NPR1(10), NPR2(10), NT5C(1), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(8), NT5E(5), NT5M(3), NUDT2(2), NUDT5(1), PAICS(3), PAPSS1(5), PAPSS2(5), PDE10A(11), PDE11A(10), PDE1A(10), PDE1C(10), PDE2A(11), PDE3B(9), PDE4A(9), PDE4B(12), PDE4C(2), PDE4D(7), PDE5A(11), PDE6D(1), PDE7B(5), PDE8A(5), PDE8B(15), PDE9A(8), PFAS(8), PKLR(5), PKM2(4), PNPT1(5), POLA1(23), POLA2(1), POLD1(11), POLD2(5), POLD3(4), POLD4(1), POLE2(2), POLE3(2), POLE4(1), POLR1A(11), POLR1B(10), POLR1C(2), POLR1D(1), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), POLR3A(5), POLR3B(6), POLR3G(2), POLR3GL(3), POLR3H(3), PPAT(7), PRIM1(2), PRIM2(7), PRPS1(3), PRPS1L1(2), PRPS2(6), PRUNE(3), RFC5(7), RRM1(2), RRM2(5), RRM2B(4), XDH(9) 57999016 736 108 718 224 189 292 105 45 105 0 0.030 0.098 189 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(17), EGFR(10), ERBB3(14), NRG1(20) 3732648 61 32 59 13 13 26 11 4 7 0 0.031 0.10 190 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(4), CD4(6), IL1B(2), IL5(1), IL5RA(7), IL6(4) 1997640 24 19 22 7 2 12 2 0 8 0 0.031 0.10 191 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 25 ADRBK1(4), AKT1(3), AKT2(4), AKT3(7), DAG1(4), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PDK1(2), PHKA2(12), PIK3CB(13), PITX2(9), PLD1(9), PLD2(7), PLD3(2), VN1R1(4) 15765608 175 61 171 65 40 76 20 9 28 2 0.035 0.11 192 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(6), BCR(4), BLNK(3), ELK1(2), FOS(2), GRB2(3), JUN(1), LYN(6), MAP2K1(2), MAP3K1(24), MAPK1(2), MAPK3(3), PAPPA(26), RAC1(1), RPS6KA1(1), RPS6KA3(15), SHC1(5), SOS1(10), SYK(3), VAV1(10), VAV2(3), VAV3(9) 10307624 141 53 137 42 44 43 22 11 19 2 0.036 0.11 193 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(4), GABARAP(1), GABRA1(8), GABRA2(10), GABRA3(12), GABRA4(12), GABRA5(6), GABRA6(6), GPHN(11), NSF(2), SRC(2), UBQLN1(4) 4361824 78 35 72 26 21 32 11 4 10 0 0.037 0.12 194 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(3), IL2RG(11), IL4R(5), IRS1(10), JAK1(16), JAK3(5), RPS6KB1(2), SHC1(5), STAT6(5) 5423264 65 38 65 23 14 29 10 3 9 0 0.037 0.12 195 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(8), GALNT10(4), GALNT2(5), GALNT3(6), GALNT4(7), GALNT6(1), GALNT7(9), GALNT8(9), GCNT1(3), ST3GAL1(1), ST3GAL2(3), ST3GAL4(3), WBSCR17(11) 5177496 70 38 68 24 15 26 16 7 6 0 0.037 0.12 196 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 29 ABP1(5), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), ALDH3A1(2), ALDH3B2(5), AOC2(6), AOC3(9), AOX1(14), DBH(7), DCT(11), DDC(9), FAH(5), GOT1(5), GOT2(3), GSTZ1(4), HPD(7), MAOA(10), MAOB(5), PNMT(1), TAT(5), TPO(11), TYR(8) 10752536 164 50 156 44 42 58 26 13 25 0 0.040 0.12 197 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(11), GBA3(7), LPO(4), MPO(6), PRDX2(4), PRDX5(1), PRDX6(2), TPO(11), TYR(8) 3365608 54 29 54 22 17 22 8 1 6 0 0.040 0.13 198 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(9), GLS2(6), GLUD1(3), GLUD2(6) 1506104 24 17 23 8 3 9 4 1 7 0 0.041 0.13 199 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(18), C5(14), C6(13), C7(16), ICAM1(1), IL6(4), IL8(3), ITGA4(8), ITGAL(12), ITGB1(5), ITGB2(10), SELP(10), SELPLG(7), VCAM1(9) 8782672 130 47 125 34 29 59 14 6 18 4 0.044 0.14 200 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(5), CDO1(4), CSAD(7), GAD1(6), GAD2(10), GGT1(5) 2106264 37 23 37 9 10 9 13 0 5 0 0.045 0.14 201 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(15), AMY2A(4), AMY2B(9), ENPP1(8), ENPP3(14), G6PC(5), GAA(4), GANAB(8), GBA3(7), GBE1(4), GCK(3), GPI(5), GUSB(4), GYS1(9), GYS2(14), HK1(9), HK2(5), HK3(8), MGAM(36), PGM1(5), PGM3(4), PYGB(9), PYGL(6), PYGM(4), RNPC3(6), SI(43), UCHL1(3), UCHL3(1), UGDH(2), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2B15(8), UGT2B4(7), UXS1(5) 20177776 308 74 305 81 87 101 55 19 46 0 0.047 0.14 202 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 5 DBH(7), GAD1(6), HDC(6), PNMT(1), TPH1(9) 1926216 29 22 28 8 8 7 7 1 4 2 0.050 0.15 203 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(5), IFNGR1(5), IFNGR2(3), JAK1(16), JAK2(14), STAT1(12) 3048168 55 27 54 17 11 17 9 3 11 4 0.052 0.16 204 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(5), GRB2(3), HBXIP(1), PTK2B(13), SHC1(5), SOS1(10), SRC(2) 3088344 39 27 37 11 10 20 4 3 2 0 0.052 0.16 205 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(23), POLA2(1), POLB(3), POLD1(11), POLD2(5), POLD3(4), POLD4(1), POLE2(2), POLE3(2), POLE4(1), POLG(5), POLG2(2), POLH(11), POLI(6), POLK(11), POLL(6), POLM(5), POLQ(18), PRIM1(2), PRIM2(7), REV1(9), REV3L(29), RFC5(7) 15226456 171 64 164 38 40 64 28 6 33 0 0.054 0.16 206 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 35 EEF1B2(3), EEF1D(7), EEF1G(3), EEF2(9), EEF2K(7), EIF1AX(1), EIF2AK1(7), EIF2AK2(13), EIF2AK3(11), EIF2B2(4), EIF2B3(7), EIF2B4(3), EIF2B5(4), EIF2S2(5), EIF2S3(5), EIF4A1(4), EIF4A2(4), EIF4E(2), EIF4EBP2(1), EIF4G1(10), EIF4G3(18), EIF5(2), EIF5A(4), EIF5B(12), ETF1(4), GSPT2(14), KIAA0664(11), PABPC1(8), PABPC3(7), PAIP1(3), SLC35A4(4) 14891408 197 67 194 49 51 80 30 8 26 2 0.054 0.16 207 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(12), GNAS(16), GNB1(1), PRKACA(4), PRKAR1A(4) 2146440 37 24 35 6 11 17 3 2 4 0 0.055 0.16 208 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 90 ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ADRB1(1), DRD1(5), DRD2(6), EGF(17), EGFR(10), GJA1(5), GJD2(6), GNA11(2), GNAI1(4), GNAI2(4), GNAI3(3), GNAS(16), GRB2(3), GRM1(18), GRM5(19), GUCY1A2(9), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(6), GUCY2F(21), HTR2A(9), HTR2B(2), HTR2C(13), ITPR1(23), ITPR2(25), ITPR3(15), KRAS(27), MAP2K1(2), MAP2K5(2), MAP3K2(8), MAPK1(2), MAPK3(3), MAPK7(11), NPR1(10), NPR2(10), NRAS(8), PDGFB(2), PDGFC(2), PDGFD(6), PDGFRA(19), PDGFRB(10), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKG1(4), PRKG2(8), PRKX(2), RAF1(5), SOS1(10), SOS2(16), SRC(2), TJP1(18), TUBA1A(6), TUBA1B(1), TUBA1C(5), TUBA3C(3), TUBA3D(2), TUBA3E(10), TUBA4A(7), TUBA8(7), TUBAL3(3), TUBB1(5), TUBB2A(2), TUBB2B(1), TUBB6(4), TUBB8(3) 46781728 666 110 626 197 189 256 113 31 71 6 0.056 0.16 209 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(4), GNAS(16), GNB1(1), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7) 3152328 49 29 46 17 11 23 4 4 7 0 0.056 0.17 210 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(5), IFNGR1(5), JAK1(16), JAK2(14), PTPRU(12), REG1A(2), STAT1(12) 4155240 67 32 66 19 12 25 9 3 14 4 0.057 0.17 211 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(4), CD28(3), CD3D(3), CD3E(1), CD3G(1), CD8A(2), ICAM1(1), ITGAL(12), ITGB2(10), PTPRC(11), THY1(1) 3785472 49 29 49 16 12 22 6 1 8 0 0.060 0.17 212 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(16), GABBR1(8), GPRC5A(4), GPRC5B(5), GPRC5C(2), GPRC5D(3), GRM1(18), GRM2(5), GRM3(14), GRM4(12), GRM5(19), GRM7(10), GRM8(17) 7453640 133 45 128 46 45 41 24 5 16 2 0.061 0.18 213 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 27 CCL4(1), CCR1(3), CCR2(4), CCR3(4), CCR4(2), CCR7(6), CD28(3), CD4(6), CXCR3(5), CXCR4(1), IFNG(5), IFNGR1(5), IFNGR2(3), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL18R1(5), IL2(2), IL4R(5), IL5(1), TGFB1(2), TGFB2(5), TGFB3(8) 7073952 102 43 101 31 17 52 10 7 16 0 0.061 0.18 214 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 32 AKT1(3), ATF1(4), CDC42(4), CREB1(5), CREB5(3), DUSP1(2), DUSP10(5), EEF2K(7), EIF4E(2), ELK1(2), IL1R1(4), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K10(6), MAP3K4(16), MAP3K5(19), MAP3K7(8), MAPK1(2), MAPK13(2), MAPK14(4), MAPKAPK2(4), MAPKAPK5(4), MKNK1(3), MKNK2(3), MYEF2(5), NFKB1(7), NR2C2(5), SRF(2), TRAF6(3) 11512904 151 53 149 47 38 68 23 9 13 0 0.061 0.18 215 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 32 AARS(6), AARS2(5), ABAT(9), ACY3(3), ADSL(5), ADSS(6), ADSSL1(5), AGXT(3), AGXT2(8), ASL(2), ASNS(5), ASPA(4), ASS1(2), CAD(21), CRAT(2), DARS(4), DARS2(6), DDO(6), DLAT(1), DLD(3), GAD1(6), GAD2(10), GOT1(5), GOT2(3), GPT2(4), NARS(7), NARS2(6), PC(9), PDHA1(4), PDHA2(8), PDHB(3) 13105312 171 59 168 65 42 71 25 10 23 0 0.062 0.18 216 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 126 ACTB(3), ACTG1(1), CHAD(1), COL11A1(22), COL11A2(6), COL17A1(18), COL1A1(7), COL1A2(15), COL2A1(10), COL3A1(12), COL4A1(15), COL4A2(5), COL4A4(17), COL4A6(28), COL5A1(24), COL5A2(17), COL5A3(17), COL6A3(34), COL6A6(20), COMP(3), DES(5), DSC2(11), DSC3(16), DSG1(15), DSG2(7), DSG4(10), FN1(31), GJA1(5), GJA10(6), GJA4(1), GJA8(5), GJA9(10), GJB1(1), GJB2(2), GJB3(2), GJB4(3), GJB5(2), GJB6(3), GJB7(6), GJC1(1), GJC3(2), GJD2(6), GJD4(3), IBSP(5), INA(3), ITGA6(10), ITGB4(6), KRT1(3), KRT10(1), KRT12(5), KRT13(5), KRT14(4), KRT15(8), KRT16(5), KRT17(4), KRT19(3), KRT2(6), KRT20(4), KRT23(7), KRT24(5), KRT25(4), KRT27(4), KRT28(3), KRT3(7), KRT31(8), KRT32(6), KRT33A(7), KRT33B(2), KRT34(8), KRT35(6), KRT36(6), KRT37(5), KRT38(8), KRT4(10), KRT5(4), KRT6A(3), KRT6B(8), KRT6C(5), KRT7(2), KRT71(3), KRT72(5), KRT73(3), KRT74(1), KRT75(4), KRT76(5), KRT77(4), KRT78(2), KRT79(3), KRT8(2), KRT81(1), KRT82(1), KRT83(2), KRT84(5), KRT85(4), KRT86(1), KRT9(7), LAMA1(27), LAMA2(52), LAMA3(22), LAMA4(13), LAMB1(21), LAMB2(20), LAMB3(12), LAMB4(22), LAMC1(13), LAMC2(11), LAMC3(10), LMNA(5), LMNB1(4), NES(26), RELN(36), SPP1(2), THBS1(9), THBS2(17), THBS3(2), THBS4(6), TNC(14), TNN(11), TNR(11), TNXB(16), VIM(7), VWF(19) 81495280 1079 130 1056 354 297 445 143 52 116 26 0.063 0.18 217 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3D(3), CD3E(1), CD3G(1), GZMB(2), HLA-A(1), ICAM1(1), ITGAL(12), ITGB2(10), PRF1(6) 2973768 39 27 38 15 8 21 5 0 5 0 0.064 0.18 218 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 7 CARS(6), CTH(4), GOT1(5), GOT2(3), LDHA(6), LDHB(2), LDHC(4) 2381792 30 24 29 14 9 10 3 5 3 0 0.066 0.19 219 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(1), CASP10(8), CASP3(3), CASP6(3), CASP7(4), CASP8(12), CFLAR(5), DAXX(6), DFFB(3), FAF1(6), JUN(1), LMNA(5), LMNB1(4), MAP2K4(4), MAP3K1(24), MAP3K7(8), MAPK8(7), PAK1(1), PAK2(3), PRKDC(40), PTPN13(20), RB1(23), RIPK2(5), SPTAN1(23) 15219760 219 57 213 60 62 67 33 11 40 6 0.066 0.19 220 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 13 POLR1B(10), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2) 4131184 53 30 53 16 9 22 6 6 10 0 0.067 0.19 221 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 107 ATP12A(13), ATP4A(6), ATP5A1(7), ATP5B(3), ATP5C1(1), ATP5E(1), ATP5F1(4), ATP5G1(2), ATP5G2(1), ATP5I(1), ATP5J(3), ATP5L(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A2(10), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(7), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), COX10(1), COX15(3), COX4I1(2), COX5A(1), COX5B(1), COX6A1(3), COX6B1(1), COX6C(2), COX7A1(2), COX7B(3), COX7B2(2), COX7C(2), COX8A(1), COX8C(1), CYC1(1), LHPP(2), NDUFA1(1), NDUFA10(6), NDUFA13(1), NDUFA2(3), NDUFA3(4), NDUFA4(1), NDUFA4L2(1), NDUFA5(4), NDUFA6(2), NDUFA8(5), NDUFA9(3), NDUFAB1(1), NDUFB1(1), NDUFB10(1), NDUFB8(1), NDUFC1(1), NDUFC2(1), NDUFS1(10), NDUFS2(4), NDUFS4(2), NDUFS5(1), NDUFS8(2), NDUFV1(2), NDUFV2(2), PPA1(3), PPA2(3), SDHA(10), SDHB(1), SDHC(4), TCIRG1(5), UQCRB(3), UQCRC1(2), UQCRC2(4), UQCRQ(2) 19545872 267 71 263 68 68 117 27 15 40 0 0.068 0.19 222 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 CHUK(7), DAXX(6), EGF(17), EGFR(10), ETS1(4), ETS2(5), FOS(2), HOXA7(8), IKBKB(8), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K14(4), MAP3K5(19), MAPK1(2), MAPK13(2), MAPK14(4), MAPK3(3), MAPK8(7), NFKB1(7), NFKBIA(2), PPP2CA(4), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCQ(6), RAF1(5), RELA(4), RIPK1(8), SP1(6), TNFRSF1A(4), TNFRSF1B(1), TRAF2(2) 17313624 232 63 228 70 46 95 39 15 35 2 0.069 0.19 223 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 36 AGT(7), AGTR2(7), CALM2(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CDK5(1), F2(8), FYN(6), GNA11(2), GNAI1(4), GNB1(1), GRB2(3), JAK2(14), MAP2K1(2), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(7), MAPT(9), MYLK(10), PLCG1(8), PRKCA(7), PTK2B(13), RAF1(5), SHC1(5), SOS1(10), STAT1(12), STAT3(8), STAT5A(2), SYT1(4) 14708880 181 62 175 58 49 72 26 9 21 4 0.069 0.19 224 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 242 ACVR1(9), ACVR1B(5), ACVR2A(5), ACVR2B(5), AMHR2(2), BMP2(5), BMP7(10), BMPR1A(4), BMPR1B(6), BMPR2(9), CCL1(1), CCL13(2), CCL14(1), CCL15(1), CCL16(1), CCL17(1), CCL18(1), CCL23(3), CCL24(2), CCL25(1), CCL28(1), CCL4(1), CCL5(2), CCL7(2), CCL8(1), CCR1(3), CCR2(4), CCR3(4), CCR4(2), CCR6(5), CCR7(6), CCR8(5), CCR9(1), CD27(1), CD40(2), CD40LG(5), CD70(2), CLCF1(1), CNTF(1), CNTFR(2), CSF1(3), CSF1R(6), CSF2RA(7), CSF2RB(9), CSF3(1), CSF3R(7), CX3CL1(3), CX3CR1(4), CXCL1(1), CXCL10(2), CXCL12(2), CXCL13(2), CXCL16(2), CXCL2(2), CXCL3(1), CXCL5(3), CXCL9(2), CXCR3(5), CXCR4(1), CXCR6(1), EDA(5), EDA2R(5), EGF(17), EGFR(10), EPO(1), EPOR(3), FAS(6), FASLG(5), FLT1(15), FLT3(7), FLT3LG(2), FLT4(9), GDF5(7), GH1(2), GH2(2), GHR(8), HGF(13), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(6), IFNAR2(6), IFNB1(2), IFNG(5), IFNGR1(5), IFNGR2(3), IFNK(2), IFNW1(1), IL10(2), IL10RA(3), IL10RB(6), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL13RA1(10), IL15(1), IL17RA(3), IL17RB(3), IL18(1), IL18R1(5), IL18RAP(11), IL19(1), IL1B(2), IL1R1(4), IL1R2(5), IL1RAP(5), IL2(2), IL20(5), IL20RA(1), IL21(2), IL21R(6), IL22RA1(2), IL22RA2(1), IL23A(4), IL23R(4), IL24(5), IL25(1), IL26(3), IL28A(2), IL28B(1), IL28RA(7), IL29(2), IL2RA(2), IL2RB(1), IL2RG(11), IL3RA(8), IL4R(5), IL5(1), IL5RA(7), IL6(4), IL6R(7), IL6ST(6), IL7(1), IL7R(7), IL8(3), IL9R(1), INHBA(3), INHBB(2), INHBC(1), INHBE(4), KDR(20), KIT(22), KITLG(2), LEP(1), LEPR(10), LIF(2), LIFR(19), LTA(2), LTBR(5), MET(9), MPL(4), NGFR(3), OSM(1), OSMR(11), PDGFB(2), PDGFC(2), PDGFRA(19), PDGFRB(10), PF4(1), PF4V1(1), PLEKHO2(3), PRL(4), PRLR(3), RELT(1), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), TNFRSF10A(2), TNFRSF10B(4), TNFRSF10C(2), TNFRSF10D(5), TNFRSF11A(4), TNFRSF11B(6), TNFRSF13B(1), TNFRSF14(2), TNFRSF19(3), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TNFRSF8(6), TNFRSF9(1), TNFSF11(5), TNFSF12(4), TNFSF13B(2), TNFSF14(2), TNFSF15(2), TNFSF18(3), TNFSF4(3), TNFSF8(1), TPO(11), TSLP(1), VEGFB(2), VEGFC(6), XCL2(1), XCR1(3) 62425320 846 119 830 260 230 326 127 47 112 4 0.070 0.19 225 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 31 AKR1B1(1), AKR1B10(3), B4GALT1(2), B4GALT2(3), G6PC(5), G6PC2(4), GAA(4), GALK1(1), GALK2(2), GALT(2), GANC(13), GCK(3), GLA(2), GLB1(4), HK1(9), HK2(5), HK3(8), HSD3B7(3), LALBA(1), LCT(24), MGAM(36), PFKM(4), PFKP(6), PGM1(5), PGM3(4), RDH11(1), RDH12(3), RDH13(4), RDH14(2), UGP2(5) 12895752 169 59 167 61 45 68 22 14 20 0 0.070 0.19 226 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(3), CD3D(3), CD3E(1), CD3G(1), IFNG(5), IL2(2), IL2RA(2), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), TGFBR3(8), TOB1(2), TOB2(5) 3856896 56 30 56 22 11 27 8 3 7 0 0.071 0.19 227 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 9 ANPEP(11), CKM(2), EIF4E(2), FBL(2), LDHA(6), LDHB(2), LDHC(4), MAPK14(4), NCL(3) 3089336 36 26 36 19 9 12 4 4 5 2 0.072 0.20 228 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(3), LPL(9), NR3C1(11), PPARG(5), RETN(1), RXRA(1) 2049472 30 21 30 6 10 8 2 2 8 0 0.074 0.20 229 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 17 ATF2(6), CHUK(7), IFNG(5), IKBKB(8), IL2(2), JUN(1), MAP3K1(24), MAP3K5(19), MAP4K5(6), MAPK14(4), MAPK8(7), NFKB1(7), NFKBIA(2), RELA(4), TNFRSF9(1), TRAF2(2) 7099496 105 37 101 30 24 43 10 8 18 2 0.074 0.20 230 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(11), GBA(3), GBA3(7), LPO(4), MPO(6), PRDX6(2), TPO(11) 2960624 44 27 44 20 16 15 6 1 6 0 0.076 0.20 231 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), IL2(2), IL2RA(2), IL2RB(1), IL2RG(11), JAK1(16), JAK3(5), JUN(1), LCK(3), MAP2K1(2), MAPK3(3), MAPK8(7), RAF1(5), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3), SYK(3) 8416128 95 45 92 23 28 38 12 6 11 0 0.077 0.20 232 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(12), ADRB2(5), GNAS(16), PLCE1(31), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3) 4951568 85 37 81 22 19 35 15 4 12 0 0.077 0.20 233 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 103 A4GNT(5), ALG1(1), ALG10(6), ALG10B(6), ALG11(4), ALG13(13), ALG14(2), ALG3(1), ALG6(3), ALG8(5), ALG9(5), B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT4(3), B4GALT5(2), B4GALT7(3), C1GALT1(2), C1GALT1C1(4), CHPF(3), CHST1(8), CHST11(7), CHST12(3), CHST14(2), CHST2(1), CHST3(3), CHST4(1), CHST7(4), DAD1(1), DDOST(3), DPAGT1(2), EXT1(10), EXT2(6), EXTL1(9), EXTL2(7), EXTL3(6), FUT11(4), FUT8(12), GALNT1(8), GALNT10(4), GALNT11(12), GALNT12(2), GALNT13(14), GALNT14(4), GALNT2(5), GALNT3(6), GALNT4(7), GALNT5(5), GALNT6(1), GALNT7(9), GALNT8(9), GALNTL1(7), GALNTL2(11), GALNTL4(4), GALNTL5(9), GANAB(8), GCNT1(3), GCNT3(3), HS2ST1(5), HS3ST1(4), HS3ST2(3), HS3ST3A1(2), HS3ST5(9), HS6ST2(9), HS6ST3(2), MAN1A1(10), MAN1A2(5), MAN1B1(3), MAN1C1(6), MAN2A1(14), MGAT1(2), MGAT2(4), MGAT3(3), MGAT4A(3), MGAT4B(5), MGAT5(7), MGAT5B(6), NDST1(11), NDST2(4), NDST3(12), NDST4(11), OGT(13), RPN1(2), RPN2(5), ST3GAL1(1), ST3GAL2(3), ST3GAL3(4), ST3GAL4(3), ST6GAL1(6), ST6GALNAC1(2), STT3B(3), UST(3), WBSCR17(11), XYLT1(10), XYLT2(3) 38453144 517 91 495 162 129 213 89 24 58 4 0.082 0.21 234 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 11 CNR1(6), CNR2(3), DNMT1(11), MTNR1A(4), MTNR1B(3), PTAFR(4), PTGDR(6), PTGER2(2), PTGER4(7), PTGFR(9), PTGIR(2) 3602696 57 32 55 22 14 28 8 4 3 0 0.082 0.21 235 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 CDK5(1), FOSB(4), GRIA2(17), PPP1R1B(2) 1266536 24 17 23 5 4 8 5 0 7 0 0.083 0.22 236 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 14 ATN1(6), CASP1(5), CASP3(3), CASP7(4), CASP8(12), GAPDH(2), INSR(12), ITCH(7), MAGI1(20), MAGI2(23), RERE(13), WWP1(12), WWP2(4) 8327344 123 43 120 37 23 60 17 4 17 2 0.083 0.22 237 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 2 FAH(5), GSTZ1(4) 480872 9 8 9 1 0 6 1 1 1 0 0.084 0.22 238 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 64 A2M(16), BDKRB1(2), BDKRB2(7), C1QA(4), C1QB(2), C1QC(4), C1R(9), C1S(5), C2(3), C3(18), C3AR1(7), C4BPA(6), C4BPB(2), C5(14), C5AR1(3), C6(13), C7(16), C8A(9), C8B(3), C9(18), CD46(1), CD55(5), CD59(3), CFB(3), CFH(15), CFI(6), CPB2(6), CR1(18), CR2(19), F10(9), F11(9), F12(2), F13A1(7), F13B(13), F2(8), F2R(6), F3(6), F5(36), F7(1), F8(34), F9(10), FGA(23), FGB(4), FGG(9), KLKB1(10), KNG1(7), MASP1(9), MASP2(5), MBL2(3), PLAT(5), PLAU(4), PLAUR(5), PLG(9), PROC(3), PROS1(1), SERPINA1(3), SERPINA5(3), SERPINC1(5), SERPIND1(4), SERPINE1(5), SERPINF2(4), SERPING1(6), TFPI(7), VWF(19) 32498168 531 86 507 152 141 218 73 28 63 8 0.085 0.22 239 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(4), CSF1(3), IL6(4), LDLR(6), LPL(9) 1946552 26 20 26 6 8 9 3 1 5 0 0.086 0.22 240 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(5), ALDH3A1(2), ALDH3B2(5), AOC2(6), AOC3(9), DDC(9), EPX(11), GOT1(5), GOT2(3), HPD(7), LPO(4), MAOA(10), MAOB(5), MPO(6), PRDX2(4), PRDX5(1), PRDX6(2), TAT(5), TPO(11) 7821672 110 41 104 42 28 38 16 9 19 0 0.091 0.23 241 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(5), CR1(18), CR2(19), FCGR2B(3), ICAM1(1), ITGAL(12), ITGB2(10), PTPRC(11) 5514032 79 37 79 22 23 32 10 3 9 2 0.099 0.25 242 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ATP6V0C(1), CAT(3), EPX(11), LPO(4), MPO(6), PRDX2(4), PRDX5(1), PRDX6(2), SHMT1(4), SHMT2(2), TPO(11) 4054056 49 31 49 22 15 21 6 1 6 0 0.100 0.25 243 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(12), DYRK1B(2), GLI2(7), GLI3(14), GSK3B(8), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), SHH(4), SMO(5), SUFU(3) 5711192 76 35 75 36 22 34 5 4 9 2 0.10 0.25 244 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(7), CYP11A1(7), CYP11B1(4), CYP11B2(5), CYP17A1(1), CYP21A2(6), HSD11B1(3), HSD3B1(1), HSD3B2(5) 3288232 44 25 44 17 8 19 4 3 10 0 0.10 0.25 245 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(7), CYP11A1(7), CYP11B1(4), CYP11B2(5), CYP17A1(1), CYP21A2(6), HSD11B1(3), HSD3B1(1), HSD3B2(5) 3288232 44 25 44 17 8 19 4 3 10 0 0.10 0.25 246 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(5), ALOX15(7), ALOX5(6), CBR1(1), CBR3(1), CYP4F2(8), CYP4F3(7), EPX(11), GGT1(5), LPO(4), LTA4H(4), MPO(6), PLA2G2E(3), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PRDX2(4), PRDX5(1), PRDX6(2), PTGDS(4), PTGES2(2), PTGIS(6), PTGS1(5), PTGS2(6), TBXAS1(4), TPO(11) 9577512 134 49 131 48 39 61 17 4 13 0 0.10 0.26 247 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(3), CD4(6) 898752 9 9 9 4 1 5 0 0 3 0 0.10 0.26 248 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(26), ABCB11(13), ABCB4(24), ABCC1(12), ABCC3(8), GSTP1(2) 5399952 85 34 82 30 26 23 13 7 14 2 0.10 0.26 249 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(42), CDC25A(7), CDC25B(2), CDC25C(5), CHEK1(2), WEE1(1), YWHAH(2) 4999184 61 31 58 10 13 17 13 0 14 4 0.10 0.26 250 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(10), ACO2(5), CS(5), DLD(3), DLST(8), FH(8), IDH1(3), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(6), MDH1(2), MDH2(4), PC(9), PCK1(8), SDHA(10), SDHB(1), SUCLA2(5), SUCLG1(3), SUCLG2(10) 7464056 108 44 107 46 32 46 13 8 9 0 0.11 0.26 251 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 67 ACACB(25), ACSL1(9), ACSL3(6), ACSL4(17), ACSL5(8), ACSL6(9), ADIPOQ(2), ADIPOR2(7), AGRP(2), AKT1(3), AKT2(4), AKT3(7), CAMKK1(9), CAMKK2(6), CD36(5), CHUK(7), CPT1A(6), CPT1B(1), CPT1C(11), CPT2(4), G6PC(5), G6PC2(4), IKBKB(8), IRS1(10), IRS4(16), JAK1(16), JAK2(14), JAK3(5), LEP(1), LEPR(10), MAPK10(7), MAPK8(7), MAPK9(4), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NPY(2), PCK1(8), PCK2(7), POMC(1), PPARGC1A(8), PRKAA1(5), PRKAA2(7), PRKAB1(6), PRKAB2(1), PRKAG1(2), PRKAG2(3), PRKAG3(5), PRKCQ(6), PTPN11(5), RELA(4), RXRA(1), RXRG(6), SLC2A1(2), SLC2A4(5), STAT3(8), TNFRSF1A(4), TNFRSF1B(1), TRAF2(2), TYK2(4) 29134544 381 84 374 131 75 168 63 17 50 8 0.11 0.26 252 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(4), ANXA2(1), ANXA3(3), ANXA4(8), ANXA5(2), ANXA6(8), CYP11A1(7), EDN1(2), EDNRA(5), HPGD(2), HSD11B1(3), PLA2G4A(9), PRL(4), PTGDR(6), PTGDS(4), PTGER2(2), PTGER4(7), PTGFR(9), PTGIR(2), PTGIS(6), PTGS1(5), PTGS2(6), SCGB1A1(1), TBXAS1(4) 7501256 110 42 110 30 33 40 15 7 15 0 0.11 0.26 253 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 79 ATF2(6), BRAF(9), CHUK(7), CREB1(5), DAXX(6), ELK1(2), FOS(2), GRB2(3), IKBKB(8), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K5(2), MAP2K6(6), MAP3K1(24), MAP3K10(6), MAP3K11(5), MAP3K12(6), MAP3K13(11), MAP3K14(4), MAP3K2(8), MAP3K3(6), MAP3K4(16), MAP3K5(19), MAP3K6(4), MAP3K7(8), MAP3K8(6), MAP3K9(3), MAP4K1(9), MAP4K2(6), MAP4K3(14), MAP4K4(7), MAP4K5(6), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK4(3), MAPK6(7), MAPK7(11), MAPK8(7), MAPK9(4), MAPKAPK2(4), MAPKAPK3(2), MAPKAPK5(4), MAX(4), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), MKNK1(3), MKNK2(3), MYC(6), NFKB1(7), NFKBIA(2), PAK1(1), PAK2(3), RAC1(1), RAF1(5), RELA(4), RIPK1(8), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA4(1), RPS6KA5(7), RPS6KB1(2), RPS6KB2(4), SHC1(5), SP1(6), STAT1(12), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TRAF2(2) 33131560 449 89 441 115 105 190 53 29 68 4 0.11 0.27 254 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(5), IFNG(5), IL12A(5), IL12B(2), IL18(1), IL2(2) 1135344 20 16 19 6 6 7 3 2 2 0 0.11 0.27 255 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(11), BID(2), BIRC2(10), BIRC3(2), CASP10(8), CASP3(3), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CFLAR(5), CHUK(7), CYCS(2), DFFB(3), GAS2(6), LMNA(5), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), SPTAN1(23), TNFRSF10A(2), TNFRSF10B(4), TNFRSF25(1), TNFSF12(4), TRAF2(2) 11713288 146 52 142 41 40 52 18 4 32 0 0.11 0.27 256 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(9), GOT1(5), GOT2(3), TAT(5), TYR(8) 1696816 30 19 30 3 5 14 5 4 2 0 0.12 0.28 257 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(17), EGFR(10), MAP2K1(2), MAP3K1(24), MAPK14(4), NCOR2(16), RARA(1), RXRA(1), THRA(4), THRB(2) 5496176 81 36 79 28 18 27 13 9 12 2 0.12 0.28 258 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(12), CD3D(3), CD3E(1), CD3G(1), CD4(6), CREBBP(24), CSK(1), GNAS(16), GNB1(1), LCK(3), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PTPRC(11), ZAP70(6) 7810512 106 44 102 33 21 50 12 5 18 0 0.12 0.28 259 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(12), CD3D(3), CD3E(1), CD3G(1), CD4(6), CREBBP(24), CSK(1), GNAS(16), GNB1(1), LCK(3), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PTPRC(11), ZAP70(6) 7810512 106 44 102 33 21 50 12 5 18 0 0.12 0.28 260 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(18), C5(14), C6(13), C7(16), C8A(9), C9(18) 4487560 88 31 83 19 16 37 15 5 11 4 0.12 0.28 261 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 20 CHUK(7), IKBKB(8), IL1R1(4), IRAK1(4), MAP3K1(24), MAP3K14(4), MAP3K7(8), MYD88(1), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), TLR4(13), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(1), TRAF6(3) 8543600 104 42 103 26 26 35 13 8 20 2 0.12 0.29 262 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CARS(6), CDO1(4), CTH(4), GOT1(5), GOT2(3), LDHA(6), LDHAL6A(7), LDHAL6B(2), LDHB(2), LDHC(4), SDS(1), SULT1B1(4), SULT1C2(4), SULT1C4(3), SULT4A1(3) 4366784 58 32 55 29 20 16 10 6 6 0 0.12 0.29 263 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 29 AGPAT2(1), AGPAT3(4), AGPAT4(3), AGPAT6(6), AGPS(9), CHPT1(1), ENPP2(18), ENPP6(8), PAFAH1B1(1), PAFAH1B2(2), PAFAH2(2), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLD1(9), PLD2(7), PPAP2A(4), PPAP2B(2) 7958568 106 43 103 29 23 48 11 4 18 2 0.12 0.29 264 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(4), IL6R(7), JAK1(16), JAK2(14), JAK3(5), PIAS3(7), PTPRU(12), REG1A(2), SRC(2), STAT3(8) 5459968 78 34 77 22 13 31 13 3 14 4 0.12 0.29 265 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(10), AP2A1(6), AP2M1(5), BIN1(3), CALM2(3), DNM1(4), EPN1(7), EPS15(8), PICALM(9), PPP3CA(2), PPP3CB(5), PPP3CC(4), SYNJ1(24), SYNJ2(8), SYT1(4) 7812248 102 43 99 41 27 38 16 5 16 0 0.13 0.29 266 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(4), ICAM1(1), ITGAL(12), ITGAM(19), ITGB2(10), SELE(5), SELL(3) 4301064 54 31 53 22 12 23 6 2 9 2 0.13 0.29 267 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(3), CHUK(7), EGR2(4), EGR3(5), MAP3K1(24), MYC(6), NFATC2(9), NFKB1(7), NFKBIA(2), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RELA(4), SYT1(4), VIP(1) 9629096 116 45 113 35 29 46 11 12 16 2 0.13 0.30 268 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 5 ACACA(27), ACACB(25), MCAT(2), OLAH(7), OXSM(5) 4386624 66 33 63 21 20 22 11 1 8 4 0.13 0.31 269 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 53 AK3(1), CAD(21), CANT1(1), CDA(1), CTPS(7), CTPS2(6), DCK(4), DCTD(4), DHODH(3), DPYD(11), DPYS(3), ENTPD1(2), NT5C(1), NT5E(5), NT5M(3), NUDT2(2), POLB(3), POLD1(11), POLD2(5), POLG(5), POLL(6), POLQ(18), POLR1B(10), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), RRM1(2), RRM2(5), TK1(1), TK2(6), TXNRD1(9), UCK1(5), UCK2(5), UMPS(5), UNG(1), UPB1(8), UPP1(3) 19896792 226 67 221 69 44 95 32 19 36 0 0.13 0.31 270 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 23 ATM(42), BMPR1B(6), CCND2(7), CDK4(3), CDKN1B(6), DAZL(5), DMC1(4), EGR1(6), ESR2(4), FSHR(14), GJA4(1), INHA(1), LHCGR(14), MLH1(7), MSH5(7), NCOR1(16), NRIP1(14), PGR(10), PRLR(3), PTGER2(2), SMPD1(10), VDR(7), ZP2(11) 12424800 200 51 192 50 44 75 29 5 41 6 0.14 0.31 271 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 83 AICDA(2), AK3(1), CAD(21), CANT1(1), CDA(1), CTPS(7), CTPS2(6), DCK(4), DCTD(4), DHODH(3), DPYD(11), DPYS(3), ENTPD1(2), ENTPD3(4), ENTPD5(2), ENTPD6(8), NME7(2), NT5C(1), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(8), NT5E(5), NT5M(3), NUDT2(2), PNPT1(5), POLA1(23), POLA2(1), POLD1(11), POLD2(5), POLD3(4), POLD4(1), POLE2(2), POLE3(2), POLE4(1), POLR1A(11), POLR1B(10), POLR1C(2), POLR1D(1), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), POLR3A(5), POLR3B(6), POLR3G(2), POLR3GL(3), POLR3H(3), PRIM1(2), PRIM2(7), RFC5(7), RRM1(2), RRM2(5), RRM2B(4), TK1(1), TK2(6), TXNRD1(9), TXNRD2(4), UCK1(5), UCK2(5), UMPS(5), UPB1(8), UPP1(3), UPP2(4), UPRT(6) 28865960 336 78 327 111 70 130 52 28 56 0 0.14 0.31 272 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(3), ACOX3(5), FADS2(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7) 3519864 38 27 38 13 7 22 4 0 5 0 0.14 0.31 273 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(11), CD14(2), CD19(3), CD1A(5), CD1B(1), CD1C(11), CD1D(3), CD1E(5), CD2(4), CD22(11), CD33(6), CD34(1), CD36(5), CD37(1), CD38(5), CD3D(3), CD3E(1), CD3G(1), CD4(6), CD44(4), CD5(5), CD55(5), CD59(3), CD8A(2), CD8B(1), CD9(3), CR1(18), CR2(19), CSF1(3), CSF1R(6), CSF2RA(7), CSF3(1), CSF3R(7), DNTT(1), EPO(1), EPOR(3), FCGR1A(5), FLT3(7), FLT3LG(2), GP1BA(9), GP5(2), GYPA(1), HLA-DRB5(2), IL11RA(5), IL1B(2), IL1R1(4), IL1R2(5), IL2RA(2), IL3RA(8), IL4R(5), IL5(1), IL5RA(7), IL6(4), IL6R(7), IL7(1), IL7R(7), IL9R(1), ITGA1(13), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGAM(19), ITGB3(10), KIT(22), KITLG(2), MME(6), MS4A1(5), TFRC(3), THPO(5), TPO(11) 30199704 411 84 404 132 116 151 55 22 61 6 0.14 0.31 274 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BAG4(3), BIRC3(2), CASP8(12), RIPK1(8), TNFRSF1A(4), TNFRSF1B(1), TRAF2(2) 2831416 32 22 31 10 5 11 5 1 10 0 0.14 0.32 275 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(12), ADRB2(5), CFTR(12), GNAS(16), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), SLC9A3R1(2) 4327104 68 32 64 16 16 31 7 3 11 0 0.15 0.33 276 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 90 ANK2(26), B3GALT4(3), CDR1(2), DGKI(16), FAU(1), IL6ST(6), MRPL19(5), PIGK(6), RPL10(4), RPL11(1), RPL14(7), RPL15(1), RPL17(5), RPL18(4), RPL18A(2), RPL19(2), RPL21(2), RPL22(3), RPL23(1), RPL24(2), RPL27(1), RPL27A(3), RPL28(2), RPL29(2), RPL3(1), RPL35A(2), RPL37(3), RPL38(1), RPL39(3), RPL3L(3), RPL4(3), RPL5(5), RPL6(2), RPL8(1), RPL9(1), RPLP0(4), RPS10(1), RPS12(2), RPS13(1), RPS18(3), RPS20(3), RPS21(1), RPS24(2), RPS25(1), RPS27(1), RPS27A(3), RPS29(2), RPS3(2), RPS3A(1), RPS4X(1), RPS6(6), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA6(12), RPS6KB1(2), RPS6KB2(4), RPS7(3), RPS8(2), RPS9(1), SLC36A2(5), TBC1D10C(1), TSPAN9(3), UBB(1), UBC(7) 18571480 237 64 224 85 63 86 36 14 38 0 0.15 0.33 277 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(3), AP2A1(6), AP2M1(5), ARF1(3), BAD(2), BTK(4), EEA1(16), GRASP(3), GSK3A(8), GSK3B(8), LYN(6), PDPK1(2), PFKM(4), PFKP(6), PLCG1(8), PRKCE(7), PRKCZ(3), RAB5A(1), RAC1(1), RPS6KB1(2), VAV2(3) 8307752 101 45 97 40 33 37 15 5 11 0 0.15 0.33 278 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(3) 187984 3 3 3 0 2 0 0 0 1 0 0.15 0.33 279 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(5), HSD3B7(3), RDH11(1), RDH12(3), RDH13(4), RDH14(2) 1712192 21 18 21 6 7 9 3 1 1 0 0.15 0.33 280 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(2), APEX1(2), CREBBP(24), DFFB(3), GZMA(6), GZMB(2), HMGB2(4), PRF1(6), SET(4) 3740832 53 29 51 18 8 21 8 4 12 0 0.15 0.34 281 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(21), GNA12(7), PRKACG(7), PRKAG1(2), PRKAR2A(3), PRKAR2B(3) 3613856 43 29 41 14 8 18 5 4 8 0 0.16 0.34 282 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 15 GATA3(2), IL5(1), MAF(2), MAP2K3(7), MAPK14(4), NFATC2(9), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3) 3646096 46 27 45 17 6 23 4 6 7 0 0.16 0.34 283 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 52 ABP1(5), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), ALDH3A1(2), ALDH3B2(5), AOC2(6), AOC3(9), AOX1(14), CARM1(4), DBH(7), DCT(11), DDC(9), ECH1(2), ESCO1(8), ESCO2(5), FAH(5), GOT1(5), GOT2(3), GSTZ1(4), HEMK1(1), HPD(7), LCMT1(2), LCMT2(8), MAOA(10), MAOB(5), METTL2B(3), METTL6(3), NAT6(1), PNMT(1), PNPLA3(6), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), SH3GLB1(6), TAT(5), TPO(11), TYR(8), TYRP1(7), WBSCR22(5) 20674520 253 65 243 69 65 90 40 16 42 0 0.16 0.35 284 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT1(2), B4GALT2(3), G6PC(5), GAA(4), GALK1(1), GALK2(2), GALT(2), GANAB(8), GCK(3), GLA(2), GLB1(4), HK1(9), HK2(5), HK3(8), LALBA(1), LCT(24), MGAM(36), PFKM(4), PFKP(6), PGM1(5), PGM3(4) 11222992 139 52 138 57 38 55 18 10 18 0 0.16 0.36 285 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(7), DUSP1(2), IKBKAP(8), IKBKB(8), LTA(2), MAP3K1(24), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), TANK(2), TNFAIP3(2), TNFRSF1B(1), TRAF1(5), TRAF2(2), TRAF3(4) 8127952 92 39 91 23 21 38 7 8 16 2 0.16 0.36 286 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(12), GNAS(16), GNB1(1), PPP2CA(4), PRKAA1(5), PRKAA2(7), PRKAB1(6), PRKAB2(1), PRKACG(7), PRKAG1(2), PRKAG2(3), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3) 5127896 78 34 75 20 17 41 7 3 10 0 0.17 0.36 287 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 21 BTK(4), DLG4(10), EPHB2(8), F2(8), F2RL1(2), F2RL2(2), JUN(1), MAP2K5(2), MAPK1(2), MAPK7(11), MAPK8(7), MYEF2(5), PLD1(9), PLD2(7), PLD3(2), PTK2(8), RAF1(5), RASAL1(11), SRC(2), TEC(5), VAV1(10) 9655136 121 47 120 47 33 45 21 3 19 0 0.17 0.36 288 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 14 CD2(4), CD3D(3), CD3E(1), CD3G(1), CD4(6), CXCR3(5), IFNG(5), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), JAK2(14), STAT4(6), TYK2(4) 5174520 75 33 74 26 13 28 11 7 12 4 0.18 0.38 289 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 54 BMP2(5), BMP4(7), BMP5(12), BMP6(4), BMP7(10), BMP8A(3), BMP8B(1), BTRC(11), CSNK1A1(4), CSNK1A1L(2), CSNK1E(3), CSNK1G1(5), CSNK1G3(6), DHH(2), FBXW11(4), GLI1(8), GLI2(7), GLI3(14), GSK3B(8), HHIP(11), IHH(3), LRP2(61), PRKACA(4), PRKACG(7), PRKX(2), PTCH1(17), PTCH2(12), RAB23(2), SHH(4), SMO(5), STK36(6), SUFU(3), WNT1(1), WNT10A(1), WNT10B(1), WNT11(3), WNT16(4), WNT2(2), WNT2B(7), WNT3(3), WNT4(1), WNT5A(4), WNT5B(3), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(3), WNT9A(1), WNT9B(1), ZIC2(1) 20735280 293 72 285 95 98 118 36 11 30 0 0.18 0.38 290 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(3), EPX(11), LPO(4), MPO(6), MTHFR(5), PRDX6(2), SHMT1(4), SHMT2(2), TPO(11) 4035952 48 29 48 20 15 18 6 1 8 0 0.18 0.38 291 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(3), CASP8(12), CFL1(1), CFLAR(5), PDE6D(1) 1352592 22 14 21 9 4 7 4 1 6 0 0.18 0.39 292 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(4), IL8(3), SLPI(2) 633144 9 9 8 0 3 3 2 0 1 0 0.19 0.40 293 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 86 AKT1(3), AKT3(7), CAPN1(2), CAPN10(7), CAPN11(6), CAPN2(5), CAPN3(8), CAPN5(6), CAPN6(4), CAPN7(4), CAPN9(8), CAPNS1(1), CAV2(1), CDC42(4), CRK(1), CSK(1), DOCK1(17), FYN(6), GIT2(6), GRB2(3), ILK(4), ITGA10(7), ITGA11(6), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGAD(5), ITGAE(7), ITGAL(12), ITGAM(19), ITGAV(6), ITGAX(7), ITGB1(5), ITGB2(10), ITGB3(10), ITGB4(6), ITGB5(4), ITGB6(4), ITGB7(4), ITGB8(4), MAP2K1(2), MAP2K3(7), MAP2K6(6), MAPK10(7), MAPK4(3), MAPK6(7), MAPK7(11), MYLK2(6), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PDPK1(2), PIK3R2(3), PTK2(8), PXN(4), RAC1(1), RAC2(2), RAP1B(2), RAPGEF1(9), RHO(3), ROCK1(15), ROCK2(10), SDCCAG8(11), SEPP1(3), SHC1(5), SHC3(9), SORBS1(14), SOS1(10), SRC(2), TLN1(20), TNS1(15), VASP(1), VAV2(3), VAV3(9), VCL(8), ZYX(11) 47185968 557 97 543 216 154 216 74 30 73 10 0.19 0.40 294 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(5), CREM(3), FOS(2), JUN(1), MAPK3(3), OPRK1(6), POLR2A(17), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3) 4489296 58 31 57 18 11 30 6 4 7 0 0.19 0.40 295 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(3), CD4(6), CD80(5), IL10(2), IL2(2) 1493952 18 13 18 9 4 8 3 0 3 0 0.20 0.42 296 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 82 CD36(5), CD44(4), CD47(5), CHAD(1), COL11A1(22), COL11A2(6), COL1A1(7), COL1A2(15), COL2A1(10), COL3A1(12), COL4A1(15), COL4A2(5), COL4A4(17), COL4A6(28), COL5A1(24), COL5A2(17), COL5A3(17), COL6A3(34), COL6A6(20), DAG1(4), FN1(31), FNDC1(20), FNDC3A(6), FNDC4(1), FNDC5(1), GP1BA(9), GP5(2), GP6(2), HMMR(12), HSPG2(16), IBSP(5), ITGA1(13), ITGA10(7), ITGA11(6), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGAV(6), ITGB1(5), ITGB3(10), ITGB4(6), ITGB5(4), ITGB6(4), ITGB7(4), ITGB8(4), LAMA1(27), LAMA2(52), LAMA3(22), LAMA4(13), LAMB1(21), LAMB2(20), LAMB3(12), LAMB4(22), LAMC1(13), LAMC2(11), LAMC3(10), RELN(36), SDC1(1), SDC2(1), SDC3(1), SDC4(3), SPP1(2), SV2A(10), SV2B(10), SV2C(9), THBS1(9), THBS2(17), THBS3(2), THBS4(6), TNC(14), TNN(11), TNR(11), TNXB(16), VWF(19) 77138416 932 121 915 319 237 382 121 55 113 24 0.20 0.42 297 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(10), IL13RA2(3), IL4R(5), JAK1(16), JAK2(14), TYK2(4) 3800848 52 26 52 17 8 15 12 4 9 4 0.20 0.42 298 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(10), IL13RA2(3), IL4R(5), JAK1(16), JAK2(14), TYK2(4) 3800848 52 26 52 17 8 15 12 4 9 4 0.20 0.42 299 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 27 AGA(3), ARSB(4), FUCA1(2), FUCA2(3), GBA(3), GLB1(4), GNS(1), GUSB(4), HEXA(1), HEXB(3), HGSNAT(7), HPSE(3), HPSE2(5), HYAL1(2), HYAL2(2), IDS(5), LCT(24), MAN2B1(11), MAN2B2(4), MAN2C1(6), MANBA(12), NAGLU(2), NEU2(4), NEU3(2), SPAM1(11) 11804304 128 49 127 56 33 59 17 8 11 0 0.20 0.42 300 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), ALOX15(7), ALOX5(6), CYP1A2(5), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2E1(1), CYP2J2(2), CYP3A4(9), CYP3A43(3), CYP3A5(4), CYP3A7(6), HSD3B7(3), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), RDH11(1), RDH12(3), RDH13(4), RDH14(2) 8490776 105 44 104 28 29 39 18 4 15 0 0.21 0.43 301 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 20 APAF1(11), ARHGDIB(1), BIRC2(10), BIRC3(2), CASP1(5), CASP10(8), CASP2(4), CASP3(3), CASP4(5), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CYCS(2), DFFB(3), GZMB(2), LMNA(5), LMNB1(4), PRF1(6) 6682360 92 34 87 26 25 31 14 2 20 0 0.21 0.44 302 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(7), ACADM(4), ACADS(4), ACADVL(4), ACSL1(9), ACSL3(6), ACSL4(17), CPT1A(6), CPT2(4), EHHADH(4), HADHA(5), PECR(4), SCP2(8), SLC25A20(3) 6056408 85 34 82 23 20 28 18 6 13 0 0.22 0.45 303 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 13 ADSL(5), ADSS(6), DHFR(3), HPRT1(2), IMPDH1(5), MTHFD2(2), POLB(3), POLD1(11), POLG(5), PRPS2(6), RRM1(2), SRM(1) 4275768 51 29 50 19 14 23 6 4 4 0 0.22 0.45 304 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 23 ABAT(9), ALDH4A1(1), ALDH5A1(5), CAD(21), CPS1(19), EPRS(7), GAD1(6), GAD2(10), GCLC(5), GCLM(2), GFPT1(8), GLS(9), GLS2(6), GLUD1(3), GLUL(6), GMPS(11), GOT1(5), GOT2(3), GPT2(4), GSS(3), NADSYN1(6), PPAT(7), QARS(4) 11630208 160 51 155 46 29 67 26 10 24 4 0.22 0.45 305 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(3), CD86(4), IFNG(5), IFNGR1(5), IFNGR2(3), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL18(1), IL18R1(5), IL2(2), IL2RA(2), IL4R(5) 4682488 61 31 60 19 13 27 5 6 10 0 0.23 0.47 306 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(8), ERBB4(19), NRG2(2), NRG3(11), PRKCA(7), PSEN1(5) 3201680 52 24 51 19 10 21 9 6 6 0 0.24 0.48 307 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(3), ACP2(1), ACP5(2), ACPP(3), ACPT(5), ENPP1(8), ENPP3(14), FLAD1(4), RFK(1), TYR(8) 3529288 49 25 49 13 11 19 12 5 2 0 0.24 0.49 308 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 26 BAG4(3), BIRC2(10), BIRC3(2), CASP3(3), CASP8(12), CFLAR(5), JUN(1), MAP2K4(4), MAP3K3(6), MAP3K7(8), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), NR2C2(5), RALBP1(4), RIPK1(8), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(2) 9320336 105 43 103 29 21 44 17 4 19 0 0.25 0.49 309 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(9), ACACA(27), ACACB(25), ACADM(4), ACAT1(4), ACAT2(4), ACSS1(3), ACSS2(7), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH6A1(3), ALDH7A1(2), ALDH9A1(1), ECHS1(2), EHHADH(4), HADHA(5), HIBCH(6), LDHA(6), LDHAL6A(7), LDHAL6B(2), LDHB(2), LDHC(4), MLYCD(3), MUT(6), PCCA(6), PCCB(7), SUCLA2(5), SUCLG1(3), SUCLG2(10) 14300424 177 54 172 48 47 63 29 13 23 2 0.25 0.49 310 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 49 AKR1C3(2), ALOX12(5), ALOX12B(8), ALOX15(7), ALOX15B(5), ALOX5(6), CBR1(1), CBR3(1), CYP2B6(11), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2E1(1), CYP2J2(2), CYP2U1(1), CYP4A11(4), CYP4A22(5), CYP4F2(8), CYP4F3(7), EPHX2(5), GGT1(5), GPX3(2), GPX5(5), GPX6(6), GPX7(1), LTA4H(4), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PTGDS(4), PTGES(2), PTGES2(2), PTGIS(6), PTGS1(5), PTGS2(6), TBXAS1(4) 13418288 177 54 173 50 49 77 25 8 18 0 0.25 0.49 311 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(11), BIRC2(10), BIRC3(2), CASP10(8), CASP3(3), CASP7(4), CASP8(12), CASP9(2), DFFB(3), GZMB(2), PRF1(6), SCAP(10), SREBF1(2), SREBF2(8) 6073024 83 36 79 26 24 26 11 3 19 0 0.25 0.49 312 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(5), PLCD1(5), PRKCA(7), TGM2(6) 1835696 23 19 23 14 9 6 3 3 2 0 0.25 0.49 313 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 22 ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), GOT1(5), GOT2(3), GPT2(4), MDH1(2), MDH2(4), ME1(7), ME3(6), PGK1(5), PGK2(2), PKLR(5), PKM2(4), RPE(2), RPIA(7), TKT(4), TKTL1(7), TKTL2(12) 6775112 94 38 91 32 24 40 11 6 13 0 0.25 0.50 314 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 30 ABAT(9), ADC(5), ALDH4A1(1), ALDH5A1(5), CAD(21), CPS1(19), EARS2(3), EPRS(7), GAD1(6), GAD2(10), GCLC(5), GCLM(2), GFPT1(8), GFPT2(10), GLS(9), GLS2(6), GLUD1(3), GLUD2(6), GLUL(6), GMPS(11), GNPNAT1(1), GOT1(5), GOT2(3), GPT2(4), GSR(4), GSS(3), NADSYN1(6), NAGK(1), PPAT(7), QARS(4) 13876096 190 55 185 59 38 83 27 10 28 4 0.25 0.50 315 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 7 B3GAT3(1), B4GALT7(3), HS3ST1(4), HS3ST2(3), HS3ST3A1(2), XYLT1(10), XYLT2(3) 2161072 26 20 26 13 6 13 4 1 2 0 0.26 0.50 316 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 7 B3GAT3(1), B4GALT7(3), HS3ST1(4), HS3ST2(3), HS3ST3A1(2), XYLT1(10), XYLT2(3) 2161072 26 20 26 13 6 13 4 1 2 0 0.26 0.50 317 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(11), POLR1B(10), POLR1C(2), POLR1D(1), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), POLR3A(5), POLR3B(6), POLR3G(2), POLR3GL(3), POLR3H(3) 8473168 86 38 85 27 20 32 9 9 16 0 0.26 0.50 318 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(6), PGLYRP2(5) 676792 11 9 10 7 4 3 1 0 3 0 0.26 0.50 319 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 63 ADAM10(3), ADAM17(8), ATP6AP1(6), ATP6V0A1(5), ATP6V0A2(10), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(7), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), CASP3(3), CCL5(2), CDC42(4), CHUK(7), CSK(1), CXCL1(1), EGFR(10), F11R(1), GIT1(8), HBEGF(2), IGSF5(6), IKBKB(8), IL8(3), JAM2(7), JAM3(2), JUN(1), LYN(6), MAP2K4(4), MAP3K14(4), MAPK10(7), MAPK13(2), MAPK14(4), MAPK8(7), MAPK9(4), MET(9), NFKB1(7), NFKB2(9), NFKBIA(2), NOD1(7), PAK1(1), PLCG1(8), PLCG2(23), PTPN11(5), PTPRZ1(35), RAC1(1), RELA(4), SRC(2), TCIRG1(5), TJP1(18) 24767512 350 72 344 110 78 154 47 17 52 2 0.27 0.51 320 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(3), GNB1(1), HTR2C(13), PLCB1(4), TUB(11) 2571016 32 23 31 10 11 11 6 3 1 0 0.27 0.51 321 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 8 ALDOB(6), ENO1(4), GPI(5), HK1(9), PGAM1(1), PGK1(5), PKLR(5) 2672696 35 21 34 10 10 13 3 2 7 0 0.27 0.51 322 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 AGA(3), FUCA1(2), FUCA2(3), GLB1(4), HEXA(1), HEXB(3), LCT(24), MAN2B1(11), MAN2B2(4), MAN2C1(6), MANBA(12), NEU2(4), NEU3(2) 7077176 79 39 78 28 20 34 13 5 7 0 0.27 0.51 323 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(5), GOT2(3), TAT(5) 934216 13 11 13 2 2 5 2 4 0 0 0.28 0.53 324 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(6), ABAT(9), ACADS(4), ACAT1(4), ACAT2(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH5A1(5), ALDH9A1(1), ECHS1(2), EHHADH(4), GAD1(6), GAD2(10), HADHA(5), HMGCL(2), L2HGDH(3), OXCT1(8), PDHA1(4), PDHA2(8), PDHB(3), SDHB(1), SDS(1) 9084736 114 44 111 33 26 45 17 10 16 0 0.28 0.53 325 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(4), BAD(2), BRAF(9), CREB1(5), CREB5(3), DUSP6(1), DUSP9(1), EEF2K(7), EIF4E(2), GRB2(3), MAP2K1(2), MAP3K8(6), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(3), MOS(6), NFKB1(7), RAP1A(3), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), SHC1(5), SOS1(10), SOS2(16), TRAF3(4) 10345816 137 49 133 42 33 53 23 10 16 2 0.28 0.53 326 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 AGA(3), FUCA1(2), FUCA2(3), GLB1(4), HEXA(1), HEXB(3), LCT(24), MAN2C1(6), MANBA(12), NEU2(4), NEU3(2) 5744672 64 34 63 23 16 23 13 5 7 0 0.28 0.53 327 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), ASPH(9), COPS5(5), CREB1(5), EDN1(2), EP300(23), EPO(1), HIF1A(12), JUN(1), LDHA(6), NOS3(6), VHL(2) 5812624 74 31 73 11 20 22 14 4 14 0 0.28 0.53 328 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(8), PRKCA(7), PTK2B(13) 2451480 31 21 30 19 9 13 4 4 1 0 0.28 0.53 329 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(10), ACO2(5), AFMID(4), CS(5), GRHPR(3), HAO1(1), HAO2(7), HYI(2), MDH1(2), MDH2(4), MTHFD1(4), MTHFD1L(11), MTHFD2(2) 4881880 60 32 59 23 23 21 7 5 4 0 0.29 0.53 330 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(6), F13A1(7), F2(8), F2R(6), FGA(23), FGB(4), FGG(9), PLAT(5), PLAU(4), PLG(9), SERPINB2(6), SERPINE1(5) 4928008 92 34 88 22 32 28 20 5 7 0 0.29 0.54 331 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(4), ASL(2), CPS1(19), GLS(9), GLUD1(3), GOT1(5) 2720064 42 21 40 11 8 17 5 2 6 4 0.29 0.54 332 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(9), F2(8), F2R(6), F3(6), F5(36), F7(1), FGA(23), FGB(4), FGG(9), PROC(3), PROS1(1), SERPINC1(5), TFPI(7) 5748144 118 35 113 24 40 43 19 7 9 0 0.29 0.54 333 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(3), DLG4(10), GRIN1(3), GRIN2A(18), GRIN2B(18), GRIN2C(5), GRIN2D(5), NOS1(14), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), SYT1(4) 8881624 119 44 117 60 25 53 23 6 12 0 0.30 0.55 334 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(15), CAPN1(2), CAPNS1(1), CAPNS2(3), CDK5(1), CDK5R1(2), CSNK1A1(4), GSK3B(8), MAPT(9), PPP2CA(4) 3212592 49 24 48 14 11 25 6 1 6 0 0.30 0.55 335 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(4), CYP11A1(7), CYP11B2(5), CYP17A1(1), HSD11B1(3), HSD3B1(1), HSD3B2(5) 2552664 26 20 26 12 6 10 2 1 7 0 0.30 0.55 336 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(4), ACAA2(2), ACADL(7), ACADM(4), ACADS(4), ACADSB(4), ACAT1(4), ACAT2(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH6A1(3), ALDH9A1(1), AOX1(14), BCAT1(5), BCKDHA(4), BCKDHB(2), ECHS1(2), EHHADH(4), HADHA(5), HADHB(3), HIBADH(3), HMGCL(2), MCCC1(7), MCCC2(4), MUT(6), OXCT1(8), PCCA(6), PCCB(7), SDS(1) 12613032 144 50 142 50 35 56 25 11 17 0 0.30 0.55 337 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(6), ACO1(10), ACO2(5), CLYBL(7), CS(5), DLD(3), DLST(8), FH(8), IDH1(3), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(6), MDH1(2), MDH2(4), OGDH(9), OGDHL(15), PC(9), PCK1(8), PCK2(7), SDHA(10), SDHB(1), SDHC(4), SUCLA2(5), SUCLG1(3), SUCLG2(10) 10859424 156 51 152 60 38 71 21 12 14 0 0.30 0.55 338 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 14 ABCA1(21), APOC1(1), APOE(1), CETP(4), CYP7A1(10), HMGCR(9), LCAT(2), LDLR(6), LIPC(5), LPL(9), LRP1(36), SCARB1(6), SOAT1(7) 9114496 117 47 115 30 36 50 15 6 10 0 0.30 0.55 339 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(6), IFNB1(2), JAK1(16), PTPRU(12), REG1A(2), STAT1(12), STAT2(5), TYK2(4) 4487064 59 30 58 20 12 24 10 5 8 0 0.31 0.56 340 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 45 APAF1(11), BAD(2), BAX(3), BCL2L1(3), BCL2L2(2), CASP1(5), CASP10(8), CASP2(4), CASP3(3), CASP4(5), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CD40(2), CD40LG(5), CRADD(2), CYCS(2), DAXX(6), DFFB(3), FAS(6), FASLG(5), IKBKE(1), LTA(2), MCL1(1), NFKB1(7), NFKBIA(2), NGFR(3), NR3C1(11), NTRK1(11), PTPN13(20), RIPK1(8), TFG(2), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(2), TRAF3(4), TRAF6(3) 15656736 185 52 182 54 50 69 28 7 31 0 0.31 0.56 341 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(3), MMP2(6), MMP9(11), RECK(13), TIMP1(3), TIMP2(1), TIMP3(8), TIMP4(1) 2711136 46 24 45 17 15 18 7 1 5 0 0.31 0.56 342 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(5), BCAT2(3), COASY(10), DPYD(11), DPYS(3), ENPP1(8), ENPP3(14), ILVBL(7), PANK1(2), PANK2(7), PANK3(4), PANK4(3), PPCDC(1), PPCS(4), UPB1(8), VNN1(6) 5983248 96 35 94 21 28 34 17 6 11 0 0.31 0.56 343 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACAA1(4), ACADL(7), ACADM(4), ACOX1(3), ACOX2(6), ACOX3(5), ACSL1(9), ACSL3(6), ACSL4(17), ACSL5(8), ACSL6(9), ADIPOQ(2), APOA2(1), APOA5(1), AQP7(4), CD36(5), CPT1A(6), CPT1B(1), CPT1C(11), CPT2(4), CYP27A1(8), CYP4A11(4), CYP4A22(5), CYP7A1(10), CYP8B1(4), DBI(1), EHHADH(4), FABP1(4), FABP2(2), FABP3(1), FABP5(3), FABP6(3), FABP7(2), FADS2(1), GK(13), GK2(18), HMGCS2(6), ILK(4), LPL(9), ME1(7), MMP1(1), NR1H3(4), OLR1(1), PCK1(8), PCK2(7), PDPK1(2), PLTP(3), PPARD(3), PPARG(5), RXRA(1), RXRG(6), SCD(6), SCP2(8), SLC27A1(8), SLC27A2(2), SLC27A4(3), SLC27A5(3), SLC27A6(9), SORBS1(14), UBC(7), UCP1(1) 23464024 324 70 317 86 84 132 52 17 39 0 0.31 0.56 344 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 DPM2(2), EGFR(10), ELK1(2), GNAS(16), GNB1(1), GRB2(3), IGF1R(10), ITGB1(5), KLK2(2), MAP2K1(2), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(3), MYC(6), NGFR(3), PDGFRA(19), PPP2CA(4), PTPRR(13), RAF1(5), RPS6KA1(1), RPS6KA5(7), SHC1(5), SOS1(10), SRC(2), STAT3(8) 11406016 147 50 142 32 35 63 23 9 15 2 0.32 0.57 345 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(9), ACACA(27), ACADL(7), ACADM(4), ACADSB(4), ACAT1(4), ACAT2(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH6A1(3), ALDH9A1(1), ECHS1(2), EHHADH(4), HADHA(5), LDHA(6), LDHB(2), LDHC(4), MLYCD(3), MUT(6), PCCA(6), PCCB(7), SDS(1), SUCLA2(5), SUCLG1(3), SUCLG2(10) 11894824 151 49 149 46 36 51 28 13 23 0 0.32 0.57 346 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(5), CS(5), DLAT(1), DLD(3), DLST(8), FH(8), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(6), MDH1(2), MDH2(4), OGDH(9), PC(9), PDHA1(4), PDHA2(8), PDHB(3), PDHX(7), PDK1(2), PDK2(3), PDK3(10), PDK4(7), PDP2(4), SDHA(10), SDHB(1), SDHC(4), SUCLA2(5), SUCLG1(3), SUCLG2(10) 10220576 149 47 147 51 37 66 18 10 18 0 0.32 0.57 347 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 12 NDUFA1(1), NDUFA10(6), NDUFA4(1), NDUFA5(4), NDUFA8(5), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(2) 2343848 35 21 34 8 11 17 2 2 3 0 0.33 0.58 348 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 16 CALM2(3), CCL4(1), CXCL12(2), CXCR4(1), FOS(2), JUN(1), MAPK14(4), MAPK8(7), PLCG1(8), PRKCA(7), PTK2B(13), SYT1(4) 4736304 53 29 52 25 16 17 7 6 7 0 0.33 0.58 349 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(10), ACO2(5), FH(8), IDH1(3), IDH2(4), MDH1(2), MDH2(4), SDHB(1), SUCLA2(5) 3250536 42 26 42 23 12 18 3 5 4 0 0.33 0.58 350 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 20 ARSB(4), ARSD(6), ARSE(5), ASAH1(6), GAL3ST1(7), GALC(3), GBA(3), GLA(2), GLB1(4), LCT(24), NEU2(4), NEU3(2), PPAP2A(4), PPAP2B(2), SMPD1(10), SMPD2(4), SPTLC1(5), SPTLC2(4), UGCG(4) 8156720 103 40 102 31 26 51 7 8 11 0 0.33 0.58 351 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(3), ACP2(1), ACP5(2), ACP6(3), ACPP(3), ACPT(5), ENPP1(8), ENPP3(14), FLAD1(4), LHPP(2), MTMR1(13), MTMR2(2), MTMR6(7), PHPT1(1), RFK(1), TYR(8) 5416816 77 31 76 22 15 28 17 5 12 0 0.33 0.59 352 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(8), AGT(7), AGTR2(7), EDN1(2), EDNRA(5), EGF(17), EGFR(10), FOS(2), JUN(1), MYC(6), NFKB1(7), PLCG1(8), PRKCA(7), RELA(4) 7517376 91 39 87 35 18 43 16 7 7 0 0.34 0.59 353 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(4), CYB5R3(5), GCK(3), GFPT1(8), GNE(8), GNPDA1(1), GNPDA2(6), HEXA(1), HEXB(3), HK1(9), HK2(5), HK3(8), PGM3(4), RENBP(3), UAP1(5) 6044752 73 35 72 30 18 24 14 7 10 0 0.34 0.59 354 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 20 ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), GOT1(5), GOT2(3), GPT2(4), MDH1(2), MDH2(4), ME1(7), ME2(5), ME3(6), PGK1(5), PKLR(5), PKM2(4), RPE(2), RPIA(7), TKT(4) 6047728 78 34 76 26 20 32 12 5 9 0 0.34 0.60 355 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 41 CDC6(1), CDC7(10), CDK2(2), DIAPH2(18), GMNN(2), MCM10(5), MCM2(4), MCM3(8), MCM4(6), MCM5(7), MCM6(4), MCM7(3), NACA(17), PCNA(2), POLA2(1), POLD1(11), POLD2(5), POLD3(4), POLD4(1), POLE2(2), PRIM1(2), RFC1(13), RFC2(3), RFC3(4), RFC4(3), RFC5(7), RPA1(5), RPA2(2), RPA3(3), RPA4(4), RPS27A(3), UBB(1), UBC(7) 17802184 170 58 163 42 58 65 17 7 23 0 0.34 0.60 356 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(9), ACAA1(4), ACAA2(2), ACADM(4), ACADS(4), ACAT1(4), ACAT2(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH6A1(3), ALDH7A1(2), ALDH9A1(1), AOX1(14), AUH(3), BCAT1(5), BCAT2(3), BCKDHA(4), BCKDHB(2), DBT(3), DLD(3), ECHS1(2), EHHADH(4), HADH(1), HADHA(5), HADHB(3), HIBADH(3), HIBCH(6), HMGCL(2), HMGCS1(3), HMGCS2(6), HSD17B10(2), HSD17B4(8), MCCC1(7), MCCC2(4), MUT(6), OXCT1(8), OXCT2(2), PCCA(6), PCCB(7) 15176856 169 54 166 49 42 68 32 11 16 0 0.35 0.60 357 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 4 ADAM17(8), DLL1(6), FURIN(4), PSEN1(5) 1817592 23 16 23 11 3 14 1 1 4 0 0.35 0.60 358 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(4), ICAM1(1), ITGA4(8), ITGAL(12), ITGB1(5), ITGB2(10), SELE(5), SELL(3) 4849640 48 29 48 22 15 16 7 4 6 0 0.36 0.61 359 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 35 ACTA1(3), ACTA2(5), ACTN2(7), ACTN3(6), ACTN4(6), DES(5), DMD(67), FAM48A(3), MYBPC1(13), MYBPC2(5), MYBPC3(10), MYH3(20), MYH6(12), MYH7(26), MYH8(25), MYL1(5), MYL2(1), MYL9(3), MYOM1(29), NEB(101), TMOD1(2), TNNC2(3), TNNI1(1), TNNI3(2), TNNT1(3), TNNT2(6), TPM1(2), TPM3(4), TPM4(3), TTN(439), VIM(7) 50949616 824 103 795 231 231 301 125 48 51 68 0.36 0.61 360 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(11), ARHGAP5(18), ARHGDIB(1), CASP1(5), CASP10(8), CASP3(3), CASP8(12), CASP9(2), CYCS(2), GZMB(2), JUN(1), PRF1(6) 4739776 71 28 68 18 17 22 11 3 16 2 0.36 0.61 361 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 B2M(2), CALR(1), CANX(4), CD4(6), CD8A(2), CD8B(1), CIITA(12), CREB1(5), CTSL1(4), CTSS(4), HLA-A(1), HLA-B(4), HLA-C(1), HLA-DMA(3), HLA-DOA(2), HLA-DOB(2), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRB5(2), HLA-E(1), HLA-F(2), HLA-G(2), HSP90AA1(6), HSP90AB1(17), HSPA5(3), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), KIR2DL1(4), KIR2DL4(2), KIR2DS4(5), KIR3DL1(6), KIR3DL2(3), KIR3DL3(2), KLRC1(2), KLRC2(3), KLRC3(1), KLRC4(2), KLRD1(1), LGMN(4), LTA(2), NFYA(6), NFYB(2), NFYC(1), PDIA3(3), PSME1(1), PSME2(1), RFX5(6), RFXANK(3), RFXAP(2), TAP1(6), TAPBP(4) 17171024 184 56 179 48 42 86 21 8 27 0 0.36 0.61 362 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(4), ACAA2(2), ACADL(7), ACADM(4), ACADS(4), ACADSB(4), ACADVL(4), ACAT1(4), ACAT2(4), ACOX1(3), ACOX3(5), ACSL1(9), ACSL3(6), ACSL4(17), ACSL5(8), ACSL6(9), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CPT1A(6), CPT1B(1), CPT1C(11), CPT2(4), CYP4A11(4), CYP4A22(5), ECHS1(2), EHHADH(4), GCDH(5), HADH(1), HADHA(5), HADHB(3), HSD17B10(2), HSD17B4(8) 17435392 200 54 196 50 45 79 39 11 26 0 0.36 0.61 363 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(27), CPT1A(6), LEP(1), LEPR(10), PRKAA1(5), PRKAA2(7), PRKAB1(6), PRKAB2(1), PRKAG1(2), PRKAG2(3) 5292568 68 31 67 20 20 26 8 3 11 0 0.36 0.62 364 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(9), ABP1(5), ACADL(7), ACADM(4), ACADSB(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), AOC2(6), AOC3(9), CNDP1(4), DPYD(11), DPYS(3), ECHS1(2), EHHADH(4), GAD1(6), GAD2(10), HADHA(5), MLYCD(3), SDS(1), SMS(7), UPB1(8) 10426168 133 47 130 51 39 39 23 13 19 0 0.37 0.63 365 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(5), AKR1D1(7), ARSB(4), ARSD(6), ARSE(5), CYP11B1(4), CYP11B2(5), HSD11B1(3), HSD17B2(2), HSD17B3(5), HSD17B8(2), HSD3B1(1), HSD3B2(5), SRD5A1(4), SRD5A2(5), STS(6), SULT1E1(9), SULT2A1(6), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2B15(8), UGT2B4(7) 9646456 133 44 126 40 40 50 15 13 15 0 0.37 0.63 366 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM2(3), CAMK1(2), CAMK1G(3), ELK1(2), FPR1(1), GNA15(1), GNB1(1), MAP2K1(2), MAP2K3(7), MAP2K6(6), MAP3K1(24), MAPK1(2), MAPK14(4), MAPK3(3), NCF1(3), NCF2(4), NFATC2(9), NFATC3(9), NFATC4(7), NFKB1(7), NFKBIA(2), PAK1(1), PIK3C2G(12), PLCB1(4), PPP3CA(2), PPP3CB(5), PPP3CC(4), RAC1(1), RAF1(5), RELA(4), SYT1(4) 13463424 144 52 142 39 38 44 25 10 25 2 0.37 0.63 367 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(5), CA1(2), CA13(1), CA14(3), CA2(2), CA3(3), CA4(1), CA5A(5), CA5B(5), CA6(2), CA7(4), CA8(5), CA9(4), CPS1(19), CTH(4), GLS(9), GLS2(6), GLUD1(3), GLUD2(6), GLUL(6), HAL(4) 7629968 101 38 96 34 35 34 11 2 15 4 0.38 0.63 368 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(4), C1QB(2), C1R(9), C1S(5), C2(3), C3(18), C5(14), C6(13), C7(16), C8A(9), C9(18) 6411048 111 34 106 33 20 47 19 7 14 4 0.38 0.63 369 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRB(1), HMOX1(3), IL10(2), IL10RA(3), IL10RB(6), IL6(4), JAK1(16), STAT1(12), STAT3(8), STAT5A(2) 4429776 57 28 56 22 11 27 7 2 10 0 0.38 0.63 370 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(7), CDC25A(7), CDC25B(2), CDC25C(5), CSK(1), GRB2(3), PRKCA(7), PTPRA(7), SRC(2) 3332376 41 25 40 18 8 11 10 4 8 0 0.38 0.63 371 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(3), CD3E(1), CD3G(1) 423088 5 5 5 1 0 2 1 0 2 0 0.38 0.63 372 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(4), ACAT2(4), HMGCL(2), OXCT1(8) 1210736 18 14 18 2 5 9 1 0 3 0 0.38 0.63 373 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(12), CALM2(3), CREB1(5), ELK1(2), FOS(2), GNAI1(4), GNAS(16), GNB1(1), JUN(1), MAP2K1(2), MAPK3(3), NFATC2(9), NFATC3(9), NFATC4(7), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), RAF1(5), RPS6KA3(15), SYT1(4) 11877216 147 48 141 42 42 51 20 11 23 0 0.38 0.63 374 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 10 ALAD(3), ALAS1(5), ALAS2(10), CPO(1), FECH(4), GATA1(5), HBB(2), HMBS(5), UROD(1), UROS(3) 2925656 39 21 38 13 6 20 6 2 5 0 0.39 0.63 375 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 22 NRF1(5), TAX1BP3(1), UBE2A(3), UBE2B(3), UBE2C(1), UBE2D2(2), UBE2D3(2), UBE2E1(2), UBE2E3(6), UBE2G1(2), UBE2H(1), UBE2J1(1), UBE2L3(2), UBE2L6(1), UBE2N(4), UBE3A(11) 3496056 47 26 47 16 9 18 11 1 8 0 0.39 0.63 376 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(3), ACP2(1), ACP5(2), ACPP(3), ACPT(5), ALPI(2), ALPL(3), ALPP(3), ALPPL2(2), CYP19A1(13), CYP1A1(9), CYP1A2(5), CYP2A13(6), CYP2A6(10), CYP2A7(4), CYP2B6(11), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2D6(1), CYP2E1(1), CYP2F1(3), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(6), CYP4B1(2), CYP4F8(6), CYP51A1(3), PON1(11) 10547688 147 45 145 51 45 52 23 9 16 2 0.39 0.64 377 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(4), ICAM1(1), ITGA4(8), ITGAL(12), ITGAM(19), ITGB1(5), ITGB2(10), SELE(5), SELL(3), SELP(10) 6316312 77 35 74 26 22 30 8 4 11 2 0.39 0.64 378 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(7), DUSP1(2), IKBKAP(8), IKBKB(8), MAP3K1(24), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(4), TNFAIP3(2), TRAF3(4), TRAF6(3) 6570760 75 33 74 21 17 28 9 7 12 2 0.40 0.65 379 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(3), DCN(7), FMOD(2), KERA(8), LUM(11) 1357552 31 16 28 10 10 12 3 1 5 0 0.40 0.65 380 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), ARG1(4), GLS(9), GLUD1(3), OAT(6) 1703760 23 16 21 8 2 11 5 1 4 0 0.40 0.65 381 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(5), ACTR3(1), ARHGAP1(2), ARHGAP4(8), ARHGAP5(18), ARHGAP6(11), ARHGEF1(9), ARHGEF11(18), ARHGEF5(4), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), CFL1(1), DIAPH1(10), GSN(4), LIMK1(6), MYL2(1), MYLK(10), OPHN1(10), PFN1(1), PIP5K1A(6), PIP5K1B(3), PPP1R12B(11), ROCK1(15), SRC(2), TLN1(20), VCL(8) 16659400 194 57 191 66 67 71 22 14 16 4 0.41 0.66 382 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(11), ARRB2(3), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CLCA1(13), CLCA2(8), CLCA4(10), CNGA3(10), CNGA4(6), CNGB1(9), GNAL(6), GUCA1A(5), GUCA1B(3), GUCA1C(3), PDE1C(10), PRKACA(4), PRKACG(7), PRKG1(4), PRKG2(8), PRKX(2) 10849752 147 48 144 60 41 59 17 6 24 0 0.41 0.66 383 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(6), CYSLTR2(3), GPR161(3), GPR171(5), GPR18(1), GPR34(6), GPR39(8), GPR45(2), GPR65(8), GPR68(3), GPR75(8) 3622536 53 25 50 23 10 20 16 3 4 0 0.41 0.66 384 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(9), ABP1(5), ACADM(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AOC2(6), AOC3(9), CNDP1(4), DPYD(11), DPYS(3), ECHS1(2), EHHADH(4), GAD1(6), GAD2(10), HADHA(5), HIBCH(6), MLYCD(3), SMS(7), SRM(1), UPB1(8) 9586936 116 43 113 38 36 34 20 11 15 0 0.41 0.66 385 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 42 ABCA1(21), ABCA10(20), ABCA12(37), ABCA13(57), ABCA3(9), ABCA4(23), ABCA5(22), ABCA6(15), ABCA8(23), ABCA9(22), ABCB1(26), ABCB10(8), ABCB11(13), ABCB4(24), ABCB5(22), ABCB6(7), ABCB7(15), ABCB8(3), ABCB9(7), ABCC1(12), ABCC10(7), ABCC11(21), ABCC12(18), ABCC2(23), ABCC3(8), ABCC4(6), ABCC5(7), ABCC6(13), ABCC8(17), ABCC9(22), ABCD1(11), ABCD2(7), ABCD3(7), ABCD4(2), ABCG1(6), ABCG2(8), ABCG4(6), ABCG5(2), ABCG8(7), CFTR(12), TAP1(6) 40677456 602 95 581 159 150 243 77 37 82 13 0.41 0.66 386 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(16), JAK2(14), JAK3(5), PIAS1(3), PIAS3(7), PTPRU(12), REG1A(2), SOAT1(7) 5002904 67 29 66 18 13 28 9 3 10 4 0.42 0.67 387 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(5), COASY(10), DPYD(11), DPYS(3), ENPP1(8), ENPP3(14), PANK1(2), PANK2(7), PANK3(4), PANK4(3), PPCS(4), UPB1(8) 4731344 79 29 78 13 24 25 14 5 11 0 0.42 0.67 388 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(5), CA1(2), CA14(3), CA2(2), CA3(3), CA4(1), CA5A(5), CA5B(5), CA6(2), CA7(4), CA8(5), CA9(4), CPS1(19), CTH(4), GLS(9), GLS2(6), GLUD1(3), GLUL(6), HAL(4) 6862160 94 36 89 26 33 30 10 2 15 4 0.42 0.67 389 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 42 ALDOA(4), ALDOB(6), ALDOC(3), DLAT(1), DLD(3), ENO1(4), ENO2(3), ENO3(3), FBP1(2), G6PC(5), GAPDH(2), GAPDHS(8), GCK(3), GOT1(5), GOT2(3), GPI(5), HK1(9), HK2(5), HK3(8), LDHA(6), LDHAL6B(2), LDHB(2), LDHC(4), MDH1(2), MDH2(4), PC(9), PCK1(8), PDHA1(4), PDHA2(8), PDHB(3), PDHX(7), PFKM(4), PFKP(6), PGAM1(1), PGAM2(1), PGK1(5), PGK2(2), PKLR(5), PKM2(4), TNFAIP1(1) 14394664 170 53 168 62 49 66 20 13 22 0 0.43 0.68 390 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(27), ACACB(25), ACAT1(4), ACAT2(4), ACOT12(9), ACSS1(3), ACSS2(7), ACYP1(2), AKR1B1(1), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), DLAT(1), DLD(3), GRHPR(3), LDHA(6), LDHAL6A(7), LDHAL6B(2), LDHB(2), LDHC(4), LDHD(1), MDH1(2), MDH2(4), ME1(7), ME2(5), ME3(6), PC(9), PCK1(8), PCK2(7), PDHA1(4), PDHA2(8), PDHB(3), PKLR(5), PKM2(4) 16478856 196 59 189 70 55 76 22 9 32 2 0.43 0.68 391 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(1), ACTR2(5), ACTR3(1), AKT1(3), ANGPTL2(4), CDC42(4), CFL1(1), CFL2(7), FLNA(27), FLNC(27), FSCN1(2), FSCN3(4), GDI1(4), GDI2(1), LIMK1(6), MYH2(31), MYLK(10), MYLK2(6), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PFN1(1), PFN2(1), RHO(3), ROCK1(15), ROCK2(10), RPS4X(1), VASP(1), WASF1(3), WASL(7) 16606328 211 59 209 62 66 84 21 9 29 2 0.43 0.68 392 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(3), CAMK1(2), CAMK1G(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), ESRRA(2), HDAC5(10), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), PPP3CA(2), PPP3CB(5), PPP3CC(4), SLC2A4(5), SYT1(4), YWHAH(2) 7029312 76 34 76 28 16 34 11 2 13 0 0.43 0.68 393 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(6), ACO1(10), ACO2(5), ACSS1(3), ACSS2(7), FH(8), IDH1(3), IDH2(4), MDH1(2), MDH2(4), SUCLA2(5) 4867744 57 30 56 29 16 22 4 7 8 0 0.43 0.68 394 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 21 APC(36), ASAH1(6), CASP3(3), CERK(6), CREB1(5), CREB5(3), CXCL2(2), DAG1(4), EPHB2(8), FOS(2), ITPKB(7), JUN(1), MAP2K4(4), MAPK1(2), MAPK10(7), MAPK8(7), MAPK8IP1(4), MAPK9(4) 8730096 111 39 110 36 29 40 8 6 22 6 0.44 0.68 395 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(2), IFNG(5), IL10(2), IL12A(5), IL12B(2), IL15(1), IL16(12), IL18(1), IL2(2), IL5(1), IL6(4), IL8(3), LTA(2) 3729672 42 25 41 13 9 19 6 2 6 0 0.44 0.68 396 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ADCY3(5), ADCY9(17), ARF1(3), ARF3(2), ARF4(2), ARF5(4), ARF6(2), ARL4D(1), ATP6V0A1(5), ATP6V0A2(10), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(7), ATP6V1A(5), ATP6V1C1(3), ATP6V1C2(10), ATP6V1D(2), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), ERO1L(5), GNAS(16), PDIA4(3), PLCG1(8), PLCG2(23), PRKCA(7), SEC61A1(2), SEC61A2(3), SEC61B(1), SEC61G(3), TRIM23(11) 13089440 197 52 191 47 53 87 19 10 26 2 0.44 0.68 397 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), BCKDK(6), CBS(9), CTH(4), MUT(6) 1639032 27 17 26 5 8 12 3 1 3 0 0.44 0.68 398 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 47 ACHE(3), AGPAT2(1), AGPAT3(4), AGPAT4(3), AGPS(9), CDS1(4), CHAT(1), CHKA(7), CPT1B(1), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKZ(8), ETNK1(8), GNPAT(6), GPD1(2), GPD2(3), LCAT(2), LGALS13(1), LYPLA1(1), LYPLA2(4), PAFAH1B1(1), PAFAH2(2), PCYT1A(1), PCYT1B(3), PEMT(1), PISD(2), PLA2G2E(3), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCB2(7), PLCG1(8), PLCG2(23), PPAP2A(4), PPAP2B(2) 16781416 200 59 198 63 57 77 29 14 21 2 0.44 0.68 399 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(3), B4GALNT1(4), GLB1(4), HEXA(1), HEXB(3), LCT(24), SLC33A1(6), ST3GAL1(1), ST3GAL2(3), ST3GAL5(2), ST6GALNAC3(7), ST6GALNAC4(3), ST6GALNAC5(2), ST6GALNAC6(4), ST8SIA1(1), ST8SIA5(5) 5898432 73 32 71 29 22 29 7 6 9 0 0.45 0.69 400 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(7), ACTN2(7), ACTN3(6), CAPN1(2), CAPNS1(1), CAPNS2(3), ITGA1(13), ITGB1(5), ITGB3(10), PTK2(8), PXN(4), RAC1(1), SPTAN1(23), SRC(2), TLN1(20) 10313080 115 45 114 49 43 42 11 4 15 0 0.45 0.69 401 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(31), RANGAP1(3) 2990880 35 21 35 5 8 11 7 2 7 0 0.45 0.69 402 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(6), AANAT(2), ABP1(5), ACAT1(4), ACAT2(4), ACMSD(8), AFMID(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AOC2(6), AOC3(9), AOX1(14), ASMT(3), CARM1(4), CAT(3), CYP1A1(9), CYP1A2(5), CYP1B1(1), DDC(9), ECHS1(2), EHHADH(4), GCDH(5), HAAO(2), HADH(1), HADHA(5), HEMK1(1), HSD17B10(2), HSD17B4(8), INMT(2), KMO(7), KYNU(3), LCMT1(2), LCMT2(8), LNX1(7), MAOA(10), MAOB(5), METTL2B(3), METTL6(3), NFX1(8), OGDH(9), OGDHL(15), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), TDO2(2), TPH1(9), TPH2(4), WARS(5), WARS2(2), WBSCR22(5) 21709920 276 66 266 77 66 112 41 21 34 2 0.45 0.69 403 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(9), FOS(2), GRB2(3), IL3RA(8), JAK2(14), MAP2K1(2), MAPK3(3), RAF1(5), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3) 6209176 66 32 64 18 16 28 10 5 3 4 0.46 0.70 404 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(7), PARK2(5), SNCA(2), SNCAIP(8), UBE2E2(2), UBE2F(1), UBE2G1(2), UBE2L3(2), UBE2L6(1) 2247376 30 19 30 11 9 12 3 4 2 0 0.46 0.70 405 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 52 ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AGK(4), AGPAT2(1), AGPAT3(4), AGPAT4(3), AGPAT6(6), AKR1A1(1), AKR1B1(1), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CEL(5), DAK(4), DGAT2(4), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKI(16), DGKZ(8), GK(13), GK2(18), GLA(2), GLB1(4), GPAM(6), LCT(24), LIPA(5), LIPC(5), LIPF(6), LIPG(4), LPL(9), MGLL(2), PNLIP(2), PNLIPRP1(3), PNLIPRP2(8), PNPLA3(6), PPAP2A(4), PPAP2B(2) 20289624 281 64 275 79 80 111 39 22 29 0 0.46 0.70 406 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GBA3(7), GGT1(5), SHMT1(4), SHMT2(2) 1543304 19 15 19 4 4 9 2 0 4 0 0.46 0.70 407 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4) 2091384 32 19 32 5 9 10 8 0 5 0 0.47 0.71 408 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHA4(14), EPHB1(19), FYN(6), ITGA1(13), ITGB1(5), L1CAM(13), LYN(6), RAP1B(2), SELP(10) 5883056 91 33 89 28 22 44 10 4 11 0 0.47 0.71 409 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(3), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), HSD3B7(3), PON1(11), PON2(6), PON3(1), RDH11(1), RDH12(3), RDH13(4), RDH14(2) 3188536 48 26 46 8 15 16 9 2 6 0 0.47 0.71 410 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(6), AADAC(4), ABAT(9), ACADS(4), ACAT1(4), ACAT2(4), ACSM1(8), AKR1B10(3), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH5A1(5), ALDH7A1(2), ALDH9A1(1), BDH1(3), BDH2(4), DDHD1(10), ECHS1(2), EHHADH(4), GAD1(6), GAD2(10), HADH(1), HADHA(5), HMGCL(2), HMGCS1(3), HMGCS2(6), HSD17B10(2), HSD17B4(8), HSD3B7(3), ILVBL(7), L2HGDH(3), OXCT1(8), OXCT2(2), PDHA1(4), PDHA2(8), PDHB(3), PLA1A(3), PPME1(1), PRDX6(2), RDH11(1), RDH12(3), RDH13(4), RDH14(2) 14378792 180 52 173 48 45 72 26 15 20 2 0.47 0.71 411 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ABP1(5), ALDH3A1(2), ALDH3B2(5), AOC2(6), AOC3(9), DDC(9), EPX(11), ESCO1(8), ESCO2(5), GOT1(5), GOT2(3), HPD(7), LPO(4), MAOA(10), MAOB(5), MPO(6), NAT6(1), PNPLA3(6), PRDX6(2), SH3GLB1(6), TAT(5), TPO(11) 12331800 131 46 125 47 35 43 21 9 23 0 0.47 0.71 412 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(6), ALDH1A2(8), BCMO1(2), RDH5(3) 1415336 19 13 19 11 7 6 1 1 4 0 0.48 0.71 413 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(7), ELK1(2), EPO(1), EPOR(3), FOS(2), GRB2(3), JAK2(14), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(7), PLCG1(8), RAF1(5), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3) 7731648 78 36 74 18 22 27 13 6 6 4 0.48 0.71 414 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(6), IFNAR2(6), IFNB1(2), JAK1(16), STAT1(12), STAT2(5), TYK2(4) 3963784 51 25 49 18 11 16 11 5 8 0 0.48 0.71 415 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 19 CD3D(3), CD3E(1), CD3G(1), CXCR3(5), ETV5(3), IFNG(5), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL18(1), IL18R1(5), JAK2(14), JUN(1), MAP2K6(6), MAPK14(4), MAPK8(7), STAT4(6), TYK2(4) 6621848 92 34 91 25 16 28 16 12 16 4 0.48 0.71 416 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 16 ACY1(3), ALDH18A1(9), ARG1(4), ARG2(3), ASL(2), CKM(2), CKMT1A(1), CKMT2(2), CPS1(19), GATM(4), GLUD1(3), OAT(6), ODC1(1), OTC(6), SMS(7) 5584216 72 31 70 25 18 31 9 3 7 4 0.48 0.71 417 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(5), AKR1D1(7), ARSD(6), ARSE(5), CARM1(4), CYP11B1(4), CYP11B2(5), CYP19A1(13), HEMK1(1), HSD11B1(3), HSD17B1(3), HSD17B12(3), HSD17B2(2), HSD17B3(5), HSD17B7(3), HSD17B8(2), HSD3B1(1), HSD3B2(5), LCMT1(2), LCMT2(8), METTL2B(3), METTL6(3), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), SRD5A1(4), SRD5A2(5), STS(6), SULT1E1(9), SULT2A1(6), SULT2B1(2), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3), WBSCR22(5) 17466640 264 56 251 72 74 100 34 19 35 2 0.48 0.71 418 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(14), BMPR1A(4), BMPR1B(6), BMPR2(9) 2225552 33 19 33 5 10 13 7 0 3 0 0.49 0.71 419 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 13 AANAT(2), ACHE(3), CHAT(1), DBH(7), DDC(9), GAD1(6), GAD2(10), HDC(6), MAOA(10), PAH(1), PNMT(1), TPH1(9) 4825336 65 29 64 16 14 19 17 1 12 2 0.49 0.71 420 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), CDK5R1(2), DRD1(5), DRD2(6), GRM1(18), PLCB1(4), PPP1CA(3), PPP1R1B(2), PPP2CA(4), PPP3CA(2), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3) 5614224 68 31 67 28 19 29 8 2 10 0 0.49 0.71 421 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 9 GCK(3), HK1(9), HK2(5), HK3(8), IMPA1(3), IMPA2(5), PGM1(5), PGM3(4), TGDS(3) 3838296 45 25 45 23 12 15 8 4 6 0 0.49 0.72 422 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 ABP1(5), AGXT(3), AGXT2(8), AKR1B10(3), ALAS1(5), ALAS2(10), AMT(2), AOC2(6), AOC3(9), BHMT(2), CBS(9), CHDH(2), CHKA(7), CTH(4), DAO(3), DLD(3), DMGDH(1), GARS(6), GATM(4), GLDC(13), GNMT(2), HSD3B7(3), MAOA(10), MAOB(5), PEMT(1), PHGDH(5), PIPOX(2), PISD(2), PSAT1(3), PSPH(1), RDH11(1), RDH12(3), RDH13(4), RDH14(2), SARDH(8), SARS(2), SARS2(3), SDS(1), SHMT1(4), SHMT2(2), TARS(5), TARS2(7) 15046904 181 51 176 67 51 71 30 9 20 0 0.49 0.72 423 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(9), F11(9), F12(2), F13B(13), F2(8), F5(36), F7(1), F8(34), F9(10), FGA(23), FGB(4), FGG(9), LPA(11), PLAT(5), PLAU(4), PLG(9), SERPINB2(6), SERPINE1(5), SERPINF2(4), VWF(19) 12544832 221 49 209 62 62 84 40 9 26 0 0.49 0.72 424 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(4), ACAA2(2), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1C4(5), AKR1D1(7), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), BAAT(5), CEL(5), CYP27A1(8), CYP7A1(10), HADHB(3), SOAT2(5), SRD5A1(4), SRD5A2(5) 8363552 120 38 116 30 39 40 19 7 15 0 0.49 0.72 425 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(3), ST3GAL1(1), ST3GAL2(3), ST3GAL4(3), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(3), ST8SIA1(1) 1899928 17 15 17 7 8 5 3 0 1 0 0.50 0.72 426 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 56 B3GALNT1(3), B3GALT1(9), B3GALT2(6), B3GALT4(3), B3GALT5(4), B3GNT1(5), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), B4GALNT1(4), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT4(3), B4GALT6(4), FUT1(3), FUT2(1), FUT3(7), FUT6(9), FUT9(7), GBGT1(5), GCNT2(10), PIGA(7), PIGB(9), PIGC(2), PIGF(2), PIGG(4), PIGH(3), PIGK(6), PIGL(1), PIGM(1), PIGN(9), PIGO(6), PIGP(2), PIGS(1), PIGT(7), PIGU(2), PIGV(6), PIGX(2), PIGZ(4), ST3GAL1(1), ST3GAL2(3), ST3GAL3(4), ST3GAL4(3), ST3GAL5(2), ST3GAL6(6), ST6GALNAC3(7), ST6GALNAC4(3), ST6GALNAC5(2), ST6GALNAC6(4), ST8SIA1(1), ST8SIA5(5), UGCG(4) 16131656 222 59 218 49 63 100 24 12 23 0 0.50 0.72 427 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 36 ABP1(5), AGXT(3), AGXT2(8), ALAS1(5), ALAS2(10), AMT(2), AOC2(6), AOC3(9), ATP6V0C(1), BHMT(2), CBS(9), CHDH(2), CHKA(7), CPT1B(1), CTH(4), DAO(3), DLD(3), DMGDH(1), GARS(6), GATM(4), GLDC(13), MAOA(10), MAOB(5), PEMT(1), PISD(2), PLCB2(7), PLCG1(8), PLCG2(23), PSPH(1), SARDH(8), SARS(2), SHMT1(4), SHMT2(2), TARS(5) 14641920 182 52 176 57 53 69 27 12 21 0 0.51 0.73 428 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(7), SUCLA2(5) 783184 12 9 11 2 2 9 0 0 1 0 0.51 0.73 429 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 6 FUT1(3), FUT2(1), FUT3(7), FUT6(9), ST3GAL3(4) 1592160 24 16 24 9 2 18 2 1 1 0 0.51 0.74 430 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(4), B3GAT2(1), B3GAT3(1), B4GALT7(3), CHPF(3), CHST11(7), CHST12(3), CHST14(2), CHST3(3), CHST7(4), DSE(14), UST(3), XYLT1(10), XYLT2(3) 4813184 61 29 60 28 14 28 14 2 3 0 0.52 0.74 431 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(3), ALAS1(5), ALAS2(10), CPOX(4), FECH(4), HMBS(5), UROD(1), UROS(3) 2826456 35 18 34 9 5 18 6 2 4 0 0.52 0.74 432 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 42 ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AGPAT2(1), AGPAT3(4), AGPAT4(3), AKR1A1(1), AKR1B1(1), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), CEL(5), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKZ(8), GK(13), GLA(2), GLB1(4), LCT(24), LIPC(5), LIPF(6), LIPG(4), LPL(9), PNLIP(2), PNLIPRP1(3), PNLIPRP2(8), PPAP2A(4), PPAP2B(2) 16470920 222 57 220 63 61 86 33 18 24 0 0.52 0.74 433 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 31 ALDH4A1(1), ARG1(4), ARG2(3), ASL(2), ASS1(2), CKM(2), CKMT1A(1), CKMT2(2), CPS1(19), DAO(3), EPRS(7), GATM(4), GLUD1(3), GLUD2(6), GOT1(5), GOT2(3), LAP3(6), NOS1(14), NOS3(6), OAT(6), OTC(6), P4HA1(5), P4HA2(10), P4HA3(2), PARS2(3), PYCR2(1), PYCRL(1), RARS(9), RARS2(6) 11903008 142 48 139 60 34 64 22 7 11 4 0.52 0.74 434 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL1(3), FOSL2(5), IFNAR1(6), IFNAR2(6), IFNB1(2), MAPK8(7), NFKB1(7), RELA(4), TNFRSF11A(4), TNFSF11(5), TRAF6(3) 4038928 54 27 52 11 14 18 14 2 6 0 0.52 0.74 435 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(4), C1QB(2), C1R(9), C1S(5), C2(3), C3(18), C5(14), C6(13), C7(16), C8A(9), C9(18), MASP1(9), MASP2(5), MBL2(3) 7723712 128 37 122 42 26 58 19 7 14 4 0.52 0.74 436 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 33 ARSD(6), ARSE(5), ASAH1(6), B4GALT6(4), CERK(6), DEGS1(5), DEGS2(4), ENPP7(2), GAL3ST1(7), GALC(3), GBA(3), GLA(2), GLB1(4), LCT(24), NEU2(4), NEU3(2), PPAP2A(4), PPAP2B(2), SGMS1(2), SGMS2(3), SGPP1(2), SGPP2(3), SMPD1(10), SMPD2(4), SMPD3(4), SMPD4(7), SPHK1(2), SPHK2(1), SPTLC1(5), SPTLC2(4), UGCG(4), UGT8(11) 11599208 155 47 152 46 48 66 11 10 20 0 0.53 0.74 437 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(4), BHMT(2), CBS(9), CTH(4), DNMT1(11), DNMT3A(8), DNMT3B(10), MARS(7), MARS2(3), MAT1A(3), MAT2B(10), MTR(7) 6094352 78 33 75 34 20 36 9 2 11 0 0.53 0.74 438 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ACTR2(5), ACTR3(1), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), NCK1(4), NCKAP1(6), NTRK1(11), PIR(4), RAC1(1), WASF1(3), WASF2(3), WASF3(7), WASL(7) 5606536 65 31 65 23 23 28 6 2 6 0 0.53 0.74 439 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(6), CS(5), MDH1(2), ME1(7), PC(9), PDHA1(4), SLC25A1(2), SLC25A11(2) 3281536 37 21 37 20 7 17 6 2 5 0 0.53 0.75 440 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(3), POLD1(11), POLD2(5), POLG(5), POLL(6), POLQ(18) 6123864 48 32 47 13 13 22 8 2 3 0 0.53 0.75 441 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(8), GTF2A1(3), GTF2B(3), GTF2E1(3), GTF2F1(5), HDAC3(8), NCOA1(15), NCOA2(13), NCOA3(8), NCOR2(16), POLR2A(17), RARA(1), RXRA(1), TBP(3) 8342472 104 38 101 40 23 46 20 5 10 0 0.53 0.75 442 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(11), BAK1(3), BAX(3), BCL2L1(3), BID(2), BIK(1), BIRC2(10), BIRC3(2), CASP3(3), CASP6(3), CASP7(4), CASP8(12), CASP9(2), CYCS(2), DFFB(3), DIABLO(2) 4777720 66 26 64 20 16 17 14 2 17 0 0.54 0.75 443 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 CSF3(1), EPO(1), FLT3(7), IGF1(2), IL6(4), KITLG(2), TGFB1(2), TGFB2(5), TGFB3(8) 2993360 32 20 32 7 7 17 4 0 4 0 0.54 0.75 444 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(7), ACADM(4), ACADS(4), ACAT1(4), ECHS1(2), HADHA(5) 1881576 26 15 26 10 3 12 4 4 3 0 0.55 0.76 445 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(11), CALM2(3), CAPN2(5), CAPNS1(1), CAPNS2(3), EP300(23), HDAC1(3), HDAC2(4), MEF2D(5), NFATC2(9), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKCA(7), SYT1(4) 8418856 89 35 88 29 19 28 15 6 19 2 0.55 0.76 446 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(3), ADCY1(12), CAP1(7), CCNB1(7), CDC25C(5), GNAI1(4), GNAS(16), GNB1(1), MAPK1(2), MAPK3(3), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RPS6KA1(1), SRC(2) 6755272 84 36 81 22 18 39 12 3 12 0 0.55 0.76 447 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(6), AASDHPPT(4), AASS(6), KARS(3) 1715912 19 14 18 7 8 4 5 2 0 0 0.55 0.76 448 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(4), CARM1(4), CBS(9), CTH(4), GGT1(5), HEMK1(1), LCMT1(2), LCMT2(8), MARS(7), MARS2(3), MAT1A(3), MAT2B(10), METTL2B(3), METTL6(3), PAPSS1(5), PAPSS2(5), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), SCLY(2), SEPHS1(10), SEPHS2(3), WBSCR22(5) 8667104 124 38 119 37 37 49 15 5 18 0 0.56 0.76 449 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(4), C1QB(2), C1R(9), C1S(5), C2(3), C3(18), C5(14), C6(13), C7(16), C8A(9), C8B(3), C9(18), MASP1(9) 7634432 123 36 116 39 23 56 19 7 14 4 0.56 0.77 450 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 22 GPAA1(4), GPLD1(7), PGAP1(8), PIGA(7), PIGB(9), PIGC(2), PIGF(2), PIGG(4), PIGH(3), PIGK(6), PIGL(1), PIGM(1), PIGN(9), PIGO(6), PIGP(2), PIGS(1), PIGT(7), PIGU(2), PIGV(6), PIGW(7), PIGX(2), PIGZ(4) 8335280 100 41 99 18 27 41 14 6 12 0 0.56 0.77 451 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 14 CHUK(7), MAP3K14(4), MAPK14(4), MAPK8(7), NFKB1(7), RELA(4), TNFRSF13B(1), TNFSF13B(2), TRAF2(2), TRAF3(4), TRAF5(6), TRAF6(3) 5151456 51 28 50 16 9 21 9 3 9 0 0.57 0.78 452 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(4), ACAT2(4), BDH1(3), BDH2(4), HMGCL(2), HMGCS1(3), HMGCS2(6), OXCT1(8), OXCT2(2) 2530096 36 21 36 6 13 15 2 2 4 0 0.57 0.78 453 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(3), HK1(9), HK2(5), HK3(8), IMPA1(3), PGM1(5), PGM3(4), TGDS(3) 3653784 40 23 40 23 12 11 8 4 5 0 0.58 0.78 454 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(16), JAK2(14), JAK3(5), MAPK1(2), MAPK3(3), STAT3(8), TYK2(4) 4198888 52 25 52 23 5 21 10 3 9 4 0.58 0.78 455 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 18 B3GNT1(5), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT4(3), FUT1(3), FUT2(1), FUT3(7), FUT6(9), FUT9(7), GCNT2(10), ST3GAL6(6), ST8SIA1(1) 5107064 72 28 71 14 17 37 6 4 8 0 0.58 0.78 456 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(6), AASDHPPT(4), AASS(6), ACAT1(4), ACAT2(4), AKR1B10(3), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), DLST(8), DOT1L(5), ECHS1(2), EHHADH(4), EHMT2(1), GCDH(5), HADH(1), HADHA(5), HSD17B10(2), HSD17B4(8), HSD3B7(3), NSD1(25), OGDH(9), OGDHL(15), PIPOX(2), PLOD1(3), PLOD2(13), PLOD3(6), RDH11(1), RDH12(3), RDH13(4), RDH14(2), SETD1A(9), SETD7(5), SETDB1(14), SHMT1(4), SHMT2(2), SPCS3(2), SUV39H1(7), SUV39H2(2), TMLHE(4) 20225392 216 62 210 66 55 87 39 14 19 2 0.58 0.78 457 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB11A(1), RAB1A(3), RAB27A(2), RAB3A(2), RAB4A(4), RAB5A(1), RAB6A(1), RAB9A(6) 1595136 23 14 22 7 9 8 3 0 3 0 0.59 0.79 458 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(12), CREM(3), FHL5(4), FSHR(14), GNAS(16), XPO1(12) 3251280 61 24 57 14 20 27 9 1 4 0 0.59 0.79 459 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(5), CHIA(2), CHIT1(4), CMAS(4), CTBS(3), CYB5R1(3), CYB5R3(5), GFPT1(8), GFPT2(10), GNE(8), GNPDA1(1), GNPDA2(6), GNPNAT1(1), HEXA(1), HEXB(3), HK1(9), HK2(5), HK3(8), LHPP(2), MTMR1(13), MTMR2(2), MTMR6(7), NAGK(1), NANS(4), NPL(5), PGM3(4), PHPT1(1), RENBP(3), UAP1(5) 10217848 133 44 131 47 31 49 22 7 24 0 0.59 0.79 460 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(15), COL4A2(5), COL4A3(19), COL4A4(17), COL4A5(19), COL4A6(28), F10(9), F11(9), F12(2), F2(8), F2R(6), F5(36), F8(34), F9(10), FGA(23), FGB(4), FGG(9), KLKB1(10), PROC(3), PROS1(1), SERPINC1(5), SERPING1(6) 16154472 278 56 267 64 83 100 43 15 32 5 0.59 0.80 461 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(9), B3GALT2(6), B3GALT5(4), B3GNT5(4), FUT1(3), FUT2(1), FUT3(7), ST3GAL3(4), ST3GAL4(3) 2672200 41 21 39 11 9 20 5 2 5 0 0.60 0.80 462 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 34 ANPEP(11), G6PD(3), GCLC(5), GCLM(2), GGT1(5), GPX3(2), GPX5(5), GPX6(6), GPX7(1), GSR(4), GSS(3), GSTA1(2), GSTA2(4), GSTA3(2), GSTA4(3), GSTA5(3), GSTK1(3), GSTM1(2), GSTM2(1), GSTM3(4), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(4), IDH1(3), IDH2(4), MGST1(4), MGST3(1), TXNDC12(4) 7264912 96 38 93 34 28 33 14 11 8 2 0.60 0.80 463 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM2(3), CDKN1A(1), NFATC2(9), NFATC3(9), NFATC4(7), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKCA(7), SP1(6), SP3(8), SYT1(4) 7233416 73 33 70 29 21 24 12 5 11 0 0.60 0.80 464 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(3), CASP7(4), DFFB(3), GZMB(2), HMGB1(2), HMGB2(4), TOP2A(11), TOP2B(19) 3651800 48 24 47 13 4 15 11 5 13 0 0.60 0.80 465 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 29 ABP1(5), ACY1(3), ADC(5), AGMAT(3), ALDH18A1(9), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(9), ARG1(4), ARG2(3), ASL(2), ASS1(2), CPS1(19), GATM(4), MAOA(10), MAOB(5), ODC1(1), OTC(6), SAT1(5), SMS(7), SRM(1) 10386984 124 43 120 51 37 47 14 8 14 4 0.61 0.80 466 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(3), HDAC9(14), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), MYOD1(3), YWHAH(2) 2920944 41 21 39 13 5 22 6 2 6 0 0.61 0.80 467 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 39 AKR1B1(1), AKR1B10(3), ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), FPGT(6), FUK(4), GMDS(3), GMPPA(5), GMPPB(1), HK1(9), HK2(5), HK3(8), HSD3B7(3), KHK(1), LHPP(2), MPI(3), MTMR1(13), MTMR2(2), MTMR6(7), PFKFB1(7), PFKFB2(1), PFKFB3(4), PFKFB4(3), PFKM(4), PFKP(6), PGM2(4), PHPT1(1), PMM2(6), RDH11(1), RDH12(3), RDH13(4), RDH14(2), SORD(3), TSTA3(3) 12474400 143 50 139 55 32 57 21 9 24 0 0.61 0.81 468 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(4), ACAA2(2), ACAD8(4), ACAD9(8), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1B10(3), AKR1C4(5), AKR1D1(7), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), BAAT(5), CEL(5), CYP27A1(8), CYP7A1(10), HADHB(3), HSD3B7(3), LIPA(5), RDH11(1), RDH12(3), RDH13(4), RDH14(2), SLC27A5(3), SOAT1(7), SOAT2(5), SRD5A1(4), SRD5A2(5) 11266888 151 44 147 37 49 53 23 7 17 2 0.61 0.81 469 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(3), LIPT1(5) 549816 8 7 8 1 1 4 2 0 1 0 0.62 0.81 470 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSA(5), FARSB(5), GOT1(5), GOT2(3), PAH(1), TAT(5), YARS(4), YARS2(2) 3187544 32 21 32 9 10 11 6 5 0 0 0.62 0.81 471 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(3), CD36(5), FOS(2), FYN(6), JUN(1), MAPK14(4), THBS1(9) 2701216 30 19 30 7 8 11 2 4 5 0 0.62 0.81 472 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 18 CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), DAG1(4), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), NFAT5(10), PDE6A(9), PDE6B(5), PDE6C(10), PDE6D(1), SLC6A13(6), TF(12) 12596168 141 47 139 54 40 55 18 3 23 2 0.62 0.81 473 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(3), ANKRD1(3), ATF3(3), CYR61(2), DUSP14(3), EIF4E(2), HBEGF(2), IFNG(5), IFRD1(6), IL18(1), IL1R1(4), MYOG(1), NR4A3(8), WDR1(9) 3764144 52 24 52 16 16 15 11 2 8 0 0.62 0.81 474 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 16 ARSB(4), GLB1(4), GNS(1), GUSB(4), HEXA(1), HEXB(3), HGSNAT(7), HPSE(3), HPSE2(5), HYAL1(2), HYAL2(2), IDS(5), LCT(24), NAGLU(2), SPAM1(11) 7048656 78 34 78 40 18 36 9 7 8 0 0.63 0.81 475 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(3), DHCR7(2), FDFT1(1), FDPS(6), HMGCR(9), HMGCS1(3), IDI1(3), MVD(3), MVK(3), NSDHL(9), PMVK(2), SC5DL(2), SQLE(4) 4303792 50 25 49 21 18 14 8 3 7 0 0.63 0.81 476 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(5), AOC2(6), AOC3(9), CES1(11), ESD(1) 2289040 32 18 29 13 10 8 8 3 3 0 0.63 0.81 477 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(4), CHPT1(1), HEMK1(1), LCMT1(2), LCMT2(8), METTL2B(3), METTL6(3), PCYT1A(1), PCYT1B(3), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), WBSCR22(5) 4952808 59 26 57 17 17 20 6 3 13 0 0.63 0.82 478 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(3), CD3E(1), CD3G(1), CD4(6), FYN(6), LCK(3), PTPRC(11), ZAP70(6) 3304600 37 21 37 8 6 16 4 1 10 0 0.64 0.82 479 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(27), ACAT1(4), ACAT2(4), ACYP1(2), AKR1B1(1), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), DLAT(1), DLD(3), GRHPR(3), LDHA(6), LDHB(2), LDHC(4), LDHD(1), MDH1(2), MDH2(4), ME1(7), ME2(5), ME3(6), PC(9), PCK1(8), PDHA1(4), PDHA2(8), PDHB(3), PKLR(5), PKM2(4) 12873680 148 49 146 54 39 56 18 8 27 0 0.64 0.82 480 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(7), CDC25B(2), CDK7(4), CDKN1A(1), CHEK1(2), NEK1(17), WEE1(1) 2677656 34 20 32 3 11 12 4 1 6 0 0.64 0.82 481 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(4), CBS(9), CTH(4), GGT1(5), MARS(7), MARS2(3), MAT1A(3), MAT2B(10), PAPSS1(5), PAPSS2(5), SCLY(2), SEPHS1(10) 4285936 67 26 64 24 21 29 9 2 6 0 0.64 0.82 482 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(4), AMD1(2), BHMT(2), CBS(9), CTH(4), DNMT1(11), DNMT3A(8), DNMT3B(10), MARS(7), MARS2(3), MAT1A(3), MAT2B(10), MTAP(2), MTR(7), SRM(1), TAT(5) 7179600 88 35 85 42 22 41 11 3 11 0 0.64 0.82 483 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(6), CARS(6), DARS(4), EPRS(7), FARS2(2), GARS(6), HARS(3), IARS(7), KARS(3), LARS(16), LARS2(7), MARS(7), MARS2(3), NARS(7), QARS(4), RARS(9), SARS(2), TARS(5), WARS(5), WARS2(2), YARS(4) 11726680 115 43 115 48 26 53 21 5 10 0 0.64 0.82 484 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(7), CCNH(3), CDC25A(7), CDC25B(2), CDC25C(5), CDK7(4), SHH(4), XPO1(12) 3142656 44 22 42 9 10 16 10 2 6 0 0.65 0.82 485 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 16 ACE(10), ACE2(17), AGT(7), AGTR1(1), AGTR2(7), ANPEP(11), CMA1(1), CPA3(4), CTSA(8), CTSG(3), ENPEP(12), LNPEP(6), MAS1(1), MME(6), NLN(4), REN(1) 7290704 99 35 95 33 31 35 16 6 9 2 0.65 0.82 486 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(10), ACO2(5), CS(5), GRHPR(3), HAO1(1), HAO2(7), HYI(2), MDH1(2), MDH2(4), MTHFD1(4), MTHFD1L(11), MTHFD2(2) 4654216 56 29 55 22 21 20 7 5 3 0 0.65 0.82 487 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 33 ACTA1(3), ACTN1(7), ACTN2(7), ACTN3(6), BCR(4), CAPN1(2), CAPNS1(1), CAPNS2(3), CRKL(4), CSK(1), FYN(6), GRB2(3), ITGA1(13), ITGB1(5), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(3), MAPK8(7), PPP1R12B(11), PTK2(8), PXN(4), RAF1(5), RAP1A(3), ROCK1(15), SHC1(5), SOS1(10), SRC(2), TLN1(20), VCL(8), ZYX(11) 16047832 182 55 178 48 60 69 24 7 20 2 0.65 0.82 488 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ABP1(5), ACY3(3), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH7A1(2), ALDH9A1(1), AMDHD1(10), AOC2(6), AOC3(9), ASPA(4), CARM1(4), CNDP1(4), DDC(9), HAL(4), HARS(3), HARS2(6), HDC(6), HEMK1(1), HNMT(4), LCMT1(2), LCMT2(8), MAOA(10), MAOB(5), METTL2B(3), METTL6(3), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), PRPS1(3), PRPS2(6), UROC1(8), WBSCR22(5) 13852536 177 49 171 53 53 58 26 11 29 0 0.65 0.82 489 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(4), GSS(3), IL8(3), NFKB1(7), NOX1(10), RELA(4), SOD1(2), XDH(9) 3707352 42 22 42 11 12 14 8 2 6 0 0.65 0.82 490 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 15 B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT4(3), CHST1(8), CHST2(1), CHST4(1), FUT8(12), ST3GAL1(1), ST3GAL2(3), ST3GAL3(4), ST3GAL4(3) 3989576 56 27 52 22 18 26 8 1 3 0 0.66 0.82 491 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ACTR2(5), ACTR3(1), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), CDC42(4), RAC1(1), WASF1(3), WASL(7) 2992864 34 20 34 10 10 15 2 0 7 0 0.66 0.82 492 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), FPGT(6), GCK(3), GMDS(3), GMPPA(5), GMPPB(1), HK1(9), HK2(5), HK3(8), KHK(1), MPI(3), PFKFB1(7), PFKFB3(4), PFKFB4(3), PFKM(4), PFKP(6), PMM2(6), SORD(3) 8502432 93 39 92 41 22 39 13 7 12 0 0.66 0.83 493 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(14), PDXK(3), PNPO(1), PSAT1(3) 1675736 21 15 21 11 6 8 3 1 3 0 0.67 0.83 494 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(4), ENO2(3), ENO3(3), FARS2(2), GOT1(5), GOT2(3), PAH(1), TAT(5), YARS(4) 3036264 30 18 30 8 5 13 5 5 2 0 0.67 0.83 495 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(4), ADORA2B(1), ADORA3(3), LTB4R(2), P2RY1(2), P2RY2(3), P2RY6(3) 2076504 21 17 21 11 6 7 6 2 0 0 0.67 0.84 496 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(6), AARS2(5), CARS(6), DARS(4), DARS2(6), EARS2(3), EPRS(7), FARS2(2), FARSA(5), FARSB(5), GARS(6), HARS(3), HARS2(6), IARS(7), IARS2(13), KARS(3), LARS(16), LARS2(7), MARS(7), MARS2(3), NARS(7), NARS2(6), PARS2(3), QARS(4), RARS(9), RARS2(6), SARS(2), SARS2(3), TARS(5), TARS2(7), VARS(4), WARS(5), WARS2(2), YARS(4), YARS2(2) 19823384 189 61 188 71 48 86 31 9 15 0 0.67 0.84 497 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 17 EXT1(10), EXT2(6), EXTL1(9), EXTL2(7), EXTL3(6), GLCE(2), HS2ST1(5), HS3ST1(4), HS3ST2(3), HS3ST3A1(2), HS3ST5(9), HS6ST2(9), HS6ST3(2), NDST1(11), NDST2(4), NDST3(12), NDST4(11) 7166208 112 37 110 32 26 50 17 4 13 2 0.68 0.84 498 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(5), CS(5), FH(8), IDH2(4), MDH1(2), OGDH(9), SDHA(10), SUCLA2(5) 3451416 48 23 48 19 12 25 5 4 2 0 0.68 0.84 499 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(18), ARHGEF1(9), GNA12(7), GNA13(7), GNB1(1), MYL2(1), MYLK(10), PLCB1(4), PPP1R12B(11), PRKCA(7), ROCK1(15) 7568216 90 34 88 30 30 30 12 6 6 6 0.69 0.85 500 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(43), MAP2(21), PPP1CA(3), PPP2CA(4), PRKACG(7), PRKAG1(2), PRKAR2A(3), PRKAR2B(3), PRKCE(7) 6711624 93 33 91 21 17 35 17 3 18 3 0.69 0.85 501 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 5 ASAH1(6), DAG1(4), ITPKB(7) 1915800 17 16 17 11 6 7 1 0 3 0 0.70 0.85 502 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(3), IL1B(2), MST1(3), MST1R(9) 2187608 17 13 16 8 7 4 1 1 4 0 0.70 0.86 503 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(6), AASDH(7), AASDHPPT(4), AASS(6), KARS(3) 2547456 26 18 25 12 10 5 7 2 2 0 0.70 0.86 504 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDFT1(1), FDPS(6), HMGCR(9), IDI1(3), MVD(3), MVK(3), NQO1(3), NQO2(4), PMVK(2), SC5DL(2), SQLE(4), VKORC1(1) 3534000 43 22 41 19 13 16 6 3 5 0 0.70 0.86 505 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(3), CAMK1(2), CAMK1G(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), CAMKK1(9), CAMKK2(6), CREB1(5), SYT1(4) 3969488 49 26 48 11 11 23 5 2 8 0 0.71 0.86 506 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(3), LDLR(6), MBTPS1(9), MBTPS2(8), SCAP(10), SREBF1(2), SREBF2(8) 3681808 46 24 45 17 11 22 5 2 6 0 0.72 0.87 507 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(3), UGDH(2), UGP2(5), UXS1(5) 1864216 17 14 16 7 5 6 3 1 2 0 0.72 0.87 508 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(3), CDK7(4), ERCC3(8), GTF2B(3), GTF2E1(3), GTF2E2(2), GTF2H1(6), ILK(4), POLR1A(11), POLR1B(10), POLR2A(17), POLR2B(14), POLR2C(3), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), POLR3B(6), POLR3D(2), POLR3E(3), POLR3H(3), TAF5(5), TAF6(6), TAF7(3), TAF9(2), TBP(3) 12831520 128 45 126 45 29 55 16 11 17 0 0.72 0.87 509 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(5), CYP2C9(4) 748464 9 7 9 3 4 4 0 0 1 0 0.72 0.88 510 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(3) 268832 3 2 3 0 1 2 0 0 0 0 0.73 0.88 511 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(13), HSD17B1(3), HSD17B2(2), HSD17B3(5), HSD17B4(8), HSD17B7(3), HSD3B1(1), HSD3B2(5) 2945000 41 22 38 17 12 18 3 1 7 0 0.73 0.88 512 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 14 ACTA1(3), APAF1(11), CASP3(3), CASP9(2), CYCS(2), DAXX(6), FAS(6), FASLG(5), HSPB2(1), MAPKAPK2(4), MAPKAPK3(2) 3952376 45 24 45 11 13 15 8 3 6 0 0.73 0.88 513 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(4), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB10(3), PSMB2(2), PSMB3(1), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(1), PSMB8(2), PSMB9(1) 3166216 34 20 32 11 4 14 5 2 9 0 0.74 0.89 514 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(4), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB2(2), PSMB3(1), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(1), PSMD14(2), RPN1(2), RPN2(5), UBE2A(3), UBE3A(11) 4810456 51 25 49 17 7 22 7 3 12 0 0.75 0.89 515 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ABP1(5), ACAT1(4), ACAT2(4), ACMSD(8), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), AOC2(6), AOC3(9), AOX1(14), ASMT(3), CAT(3), CYP19A1(13), CYP1A1(9), CYP1A2(5), CYP2A13(6), CYP2A6(10), CYP2A7(4), CYP2B6(11), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2D6(1), CYP2E1(1), CYP2F1(3), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(6), CYP4B1(2), CYP4F8(6), CYP51A1(3), DDC(9), ECHS1(2), EHHADH(4), GCDH(5), HAAO(2), HADHA(5), KMO(7), KYNU(3), MAOA(10), MAOB(5), SDS(1), TDO2(2), TPH1(9), WARS(5), WARS2(2) 20085024 266 60 262 87 76 96 40 18 32 4 0.75 0.90 516 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 25 ALDOA(4), ALDOB(6), ALDOC(3), DERA(8), FBP1(2), G6PD(3), GPI(5), H6PD(4), PFKM(4), PFKP(6), PGD(2), PGLS(1), PGM1(5), PGM3(4), PRPS1(3), PRPS1L1(2), PRPS2(6), RPE(2), RPIA(7), TALDO1(3), TKT(4), TKTL1(7), TKTL2(12) 8161928 103 39 98 35 28 43 14 5 13 0 0.75 0.90 517 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 27 ATG12(1), ATG3(2), ATG5(3), ATG7(2), GABARAP(1), GABARAPL1(2), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNG(5), PIK3C3(9), PIK3R4(17), PRKAA1(5), PRKAA2(7), ULK2(7), ULK3(5) 7000048 88 32 88 24 27 35 12 4 10 0 0.75 0.90 518 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(4), COQ5(3), COQ6(3), COQ7(3), NDUFA13(1) 1462208 14 12 14 5 2 7 3 0 2 0 0.76 0.90 519 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(2), BNIP1(2), SNAP23(1), SNAP25(7), SNAP29(1), STX10(1), STX11(3), STX12(3), STX16(1), STX17(1), STX18(1), STX3(6), STX4(4), STX5(5), STX6(3), STX7(4), STX8(2), TSNARE1(3), USE1(4), VAMP1(1), VAMP4(1), VTI1B(5), YKT6(4) 5946048 65 31 62 24 15 30 8 3 9 0 0.76 0.90 520 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR1(13), MTMR2(2), MTMR6(7), NFS1(2), PHPT1(1), TPK1(2) 2294000 29 16 28 12 5 9 6 0 9 0 0.76 0.90 521 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(2), HADH(1), HADHA(5), HADHB(3), HSD17B10(2), HSD17B4(8), MECR(6), PPT1(2), PPT2(1) 3002784 32 20 31 7 6 11 7 7 1 0 0.76 0.90 522 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(7), NFKBIA(2), PLCB1(4), PRKCA(7), RELA(4) 3000800 24 18 24 16 2 10 6 3 3 0 0.76 0.90 523 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(8), CLOCK(6), CRY1(5), CRY2(2), CSNK1E(3), NPAS2(7), NR1D1(3), PER1(9), PER2(6), PER3(10) 5806176 59 29 56 16 21 21 7 2 8 0 0.76 0.90 524 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(6), BFAR(6), BRAF(9), CREB1(5), CREB5(3), MAPK1(2), RAF1(5), SNX13(11), SRC(2), TERF2IP(2) 4115560 51 23 51 10 9 19 11 3 9 0 0.76 0.90 525 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), HEMK1(1), LCMT1(2), LCMT2(8), METTL2B(3), METTL6(3), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), WBSCR22(5) 5201304 68 26 66 14 18 25 7 3 15 0 0.76 0.90 526 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(7), AMT(2), ATIC(6), ATP6V0C(1), DHFR(3), GART(6), MTHFD1(4), MTHFD1L(11), MTHFD2(2), MTHFR(5), MTR(7), SHMT1(4), SHMT2(2) 6538024 60 31 58 22 14 30 6 3 7 0 0.77 0.90 527 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(8), CLOCK(6), CRY1(5), CRY2(2), CSNK1E(3), PER1(9) 2852744 33 19 32 9 13 10 5 1 4 0 0.77 0.90 528 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 20 F2(8), F2R(6), GNAI1(4), GNB1(1), ITGA1(13), ITGB1(5), MAP2K1(2), MAPK1(2), MAPK3(3), PLA2G4A(9), PLCB1(4), PRKCA(7), PTGS1(5), PTK2(8), RAF1(5), SRC(2), SYK(3), TBXAS1(4) 8641312 91 36 91 32 23 31 19 6 12 0 0.77 0.90 529 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 37 ARNTL(8), AZIN1(3), CBX3(3), CLOCK(6), CRY1(5), CRY2(2), DNAJA1(2), EIF4G2(6), ETV6(5), GFRA1(6), GSTM3(4), GSTP1(2), HERPUD1(2), HSPA8(7), IDI1(3), KLF9(3), MYF6(5), NCKAP1(6), NCOA4(6), NR1D2(1), PER1(9), PER2(6), PIGF(2), PPP1R3C(3), PPP2CB(2), PSMA4(1), SF3A3(5), SUMO3(2), TOB1(2), UGP2(5), VAPA(5), ZFR(9) 12857064 136 44 132 36 40 53 19 9 15 0 0.78 0.91 530 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(6), NR0B2(2), NR1H3(4), NR1H4(6), RXRA(1) 1914808 22 16 22 5 3 12 4 0 3 0 0.78 0.91 531 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 12 ACAA1(4), ACOX1(3), ACOX3(5), ELOVL2(6), ELOVL5(2), ELOVL6(2), FADS1(4), FADS2(1), HADHA(5), HSD17B12(3), PECR(4), SCD(6) 3856400 45 22 45 12 10 20 8 3 4 0 0.79 0.91 532 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(10), CD44(4), CSF1(3), FCGR3A(1), IL1B(2), IL6R(7), SELL(3), SPN(1), TGFB1(2), TGFB2(5), TNFRSF1A(4), TNFRSF1B(1), TNFRSF8(6), TNFSF8(1) 4773008 50 26 47 18 11 19 9 3 8 0 0.79 0.91 533 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 40 ABP1(5), AGMAT(3), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH4A1(1), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(9), ARG1(4), ARG2(3), ASL(2), CKM(2), CKMT1A(1), CKMT2(2), CPS1(19), DAO(3), GATM(4), GLUD1(3), GOT1(5), GOT2(3), MAOA(10), MAOB(5), NOS1(14), NOS3(6), OAT(6), ODC1(1), OTC(6), P4HA1(5), P4HA2(10), P4HA3(2), RARS(9), SMS(7) 14916952 183 50 178 67 49 76 21 14 19 4 0.79 0.91 534 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(5), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT5(2), FUT8(12), ST3GAL1(1), ST3GAL2(3), ST3GAL3(4), ST3GAL4(3) 2704192 41 20 37 11 14 18 7 0 2 0 0.79 0.91 535 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(15), COL4A2(5), COL4A3(19), COL4A4(17), COL4A5(19), COL4A6(28), SLC23A1(6), SLC23A2(4), SLC2A1(2), SLC2A3(8) 9232792 123 39 120 36 36 49 12 7 14 5 0.79 0.91 536 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(6), IDI1(3), SQLE(4) 1173288 14 10 14 2 5 4 3 1 1 0 0.80 0.92 537 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(3), ACP2(1), ACP5(2), ACP6(3), ACPP(3), ACPT(5), ALPI(2), ALPL(3), ALPP(3), ALPPL2(2), CMBL(3), CYP3A4(9), CYP3A43(3), CYP3A5(4), CYP3A7(6), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), PON1(11), PON2(6), PON3(1) 6301928 84 31 82 26 20 26 18 7 13 0 0.80 0.92 538 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(3), CHRNA1(6), SNAP25(7) 1192384 16 13 15 4 7 5 3 0 1 0 0.81 0.92 539 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(3), GBA3(7), GGT1(5), SHMT1(4), SHMT2(2) 2042776 21 15 21 9 4 11 2 0 4 0 0.81 0.92 540 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 46 ADCY4(7), ADCY6(10), ADCY8(15), CACNA1A(15), GNAS(16), GNAT3(6), GNB1(1), GNG13(2), GNG3(2), GRM4(12), ITPR3(15), KCNB1(11), PDE1A(10), PLCB2(7), PRKACA(4), PRKACG(7), PRKX(2), SCNN1A(2), SCNN1B(4), SCNN1G(8), TAS1R1(7), TAS1R2(8), TAS2R1(4), TAS2R10(5), TAS2R13(2), TAS2R14(5), TAS2R16(2), TAS2R3(2), TAS2R38(3), TAS2R39(7), TAS2R4(2), TAS2R40(4), TAS2R41(2), TAS2R42(3), TAS2R46(2), TAS2R5(3), TAS2R50(2), TAS2R60(5), TAS2R7(2), TAS2R8(5) 19686240 231 54 225 88 67 97 30 12 25 0 0.81 0.92 541 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(10), AGT(7), AGTR1(1), AGTR2(7), BDKRB2(7), KNG1(7), NOS3(6), REN(1) 3176880 46 21 43 11 16 22 3 2 3 0 0.81 0.92 542 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(3), UGDH(2), UXS1(5) 1475600 12 11 12 7 3 4 3 1 1 0 0.81 0.92 543 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(17), AGT(7), AGTR1(1), AGTR2(7), CMA1(1), COL4A1(15), COL4A2(5), COL4A3(19), COL4A4(17), COL4A5(19), COL4A6(28), REN(1) 9366464 137 40 133 31 43 56 12 7 14 5 0.82 0.93 544 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(11), G6PD(3), GCLC(5), GCLM(2), GGT1(5), GPX3(2), GPX5(5), GSS(3), GSTA1(2), GSTA2(4), GSTA3(2), GSTA4(3), GSTM1(2), GSTM2(1), GSTM3(4), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(4), IDH1(3), IDH2(4), MGST1(4), MGST3(1), PGD(2) 6509008 77 33 75 27 22 28 10 11 4 2 0.82 0.93 545 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(11), BAD(2), BAK1(3), BAX(3), BCL10(2), BCL2L1(3), BCL2L11(5), BID(2), CASP8AP2(3), CASP9(2), CES1(11) 4133664 47 23 46 8 9 16 14 1 7 0 0.82 0.93 546 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(11), EIF2AK4(5), EIF2B5(4), EIF2S2(5), EIF2S3(5), EIF5(2), GSK3B(8), PPP1CA(3) 4211288 43 25 42 10 11 19 5 2 6 0 0.83 0.93 547 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(5), APOBEC1(7), APOBEC2(3), APOBEC3A(1), APOBEC3B(6), APOBEC3C(4), APOBEC3F(4), APOBEC3G(2), APOBEC4(4) 2687080 36 20 36 9 9 19 6 1 1 0 0.83 0.93 548 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(2), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(1), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH9A1(1), ALDOA(4), ALDOB(6), ALDOC(3), BPGM(1), DLAT(1), DLD(3), ENO1(4), ENO2(3), ENO3(3), FBP1(2), G6PC(5), GAPDH(2), GCK(3), GPI(5), HK1(9), HK2(5), HK3(8), LDHA(6), LDHB(2), LDHC(4), PDHA1(4), PDHA2(8), PDHB(3), PFKM(4), PFKP(6), PGAM1(1), PGK1(5), PGM1(5), PGM3(4), PKLR(5), PKM2(4) 17239968 193 54 191 67 54 73 25 12 29 0 0.83 0.93 549 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(2), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(1), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH9A1(1), ALDOA(4), ALDOB(6), ALDOC(3), BPGM(1), DLAT(1), DLD(3), ENO1(4), ENO2(3), ENO3(3), FBP1(2), G6PC(5), GAPDH(2), GCK(3), GPI(5), HK1(9), HK2(5), HK3(8), LDHA(6), LDHB(2), LDHC(4), PDHA1(4), PDHA2(8), PDHB(3), PFKM(4), PFKP(6), PGAM1(1), PGK1(5), PGM1(5), PGM3(4), PKLR(5), PKM2(4) 17239968 193 54 191 67 54 73 25 12 29 0 0.83 0.93 550 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(15), AMY2A(4), AMY2B(9), ASCC3(25), ATP13A2(4), DDX18(10), DDX19A(1), DDX23(8), DDX4(13), DDX41(1), DDX47(4), DDX50(8), DDX52(5), DDX54(6), DDX55(5), DDX56(4), DHX58(5), ENPP1(8), ENPP3(14), ENTPD7(6), ERCC2(1), ERCC3(8), G6PC(5), G6PC2(4), GAA(4), GANC(13), GBA(3), GBA3(7), GBE1(4), GCK(3), GPI(5), GUSB(4), GYS1(9), GYS2(14), HK1(9), HK2(5), HK3(8), IFIH1(3), LYZL1(1), MGAM(36), NUDT5(1), NUDT8(1), PGM1(5), PGM3(4), PYGB(9), PYGL(6), PYGM(4), RAD54B(12), RAD54L(3), RUVBL2(4), SETX(29), SI(43), SKIV2L2(15), SMARCA2(18), SMARCA5(14), TREH(2), UGDH(2), UGP2(5), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3), UXS1(5) 43804240 589 85 570 154 153 207 110 39 73 7 0.83 0.93 551 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(4), CFL1(1), GNAS(16), GNB1(1), LIMK1(6), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(1), NOX1(10), PIK3C2G(12), PLCB1(4), PPP1R12B(11), PRKCA(7), PTK2(8), RAF1(5), ROCK2(10) 9087960 103 37 100 30 29 36 19 7 12 0 0.84 0.93 552 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(5), CALCR(4), CALCRL(7), CD97(7), CRHR1(2), CRHR2(1), ELTD1(10), EMR1(19), EMR2(3), GHRHR(1), GIPR(3), GLP1R(5), GLP2R(8), GPR64(8), LPHN1(11), LPHN2(19), LPHN3(14), SCTR(3), VIPR1(2) 9781120 132 39 127 49 30 65 12 8 15 2 0.84 0.93 553 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(3), CAPN1(2), CAPN2(5), CAPNS1(1), CAPNS2(3), CXCR3(5), EGF(17), EGFR(10), ITGA1(13), ITGB1(5), MAPK1(2), MAPK3(3), MYL2(1), MYLK(10), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PTK2(8), PXN(4), TLN1(20) 11861344 133 43 131 41 33 57 20 5 18 0 0.84 0.93 554 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(7), AMT(2), ATIC(6), DHFR(3), GART(6), MTHFD1(4), MTHFD1L(11), MTHFD2(2), MTHFR(5), MTR(7), SHMT1(4), SHMT2(2) 6685832 59 30 57 23 13 30 6 3 7 0 0.84 0.93 555 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 62 ACSS1(3), ACSS2(7), ACYP1(2), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(1), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH7A1(2), ALDH9A1(1), ALDOA(4), ALDOB(6), ALDOC(3), BPGM(1), DLAT(1), DLD(3), ENO1(4), ENO2(3), ENO3(3), FBP1(2), G6PC(5), G6PC2(4), GAPDH(2), GAPDHS(8), GCK(3), GPI(5), HK1(9), HK2(5), HK3(8), LDHA(6), LDHAL6A(7), LDHAL6B(2), LDHB(2), LDHC(4), PDHA1(4), PDHA2(8), PDHB(3), PFKM(4), PFKP(6), PGAM1(1), PGAM2(1), PGK1(5), PGK2(2), PGM1(5), PGM3(4), PKLR(5), PKM2(4) 19935232 215 56 212 76 64 78 29 15 29 0 0.84 0.93 556 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(11), CD2(4), CD33(6), CD5(5), IFNB1(2), IFNG(5), IL10(2), IL12A(5), IL12B(2), IL5(1), ITGAX(7), TLR2(11), TLR4(13), TLR7(12), TLR9(5) 6853480 91 32 89 32 27 36 13 4 9 2 0.86 0.95 557 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CYP2C19(5), CYP2C9(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), ECHS1(2), EHHADH(4), ESCO1(8), ESCO2(5), HADHA(5), NAT6(1), PNPLA3(6), SH3GLB1(6), YOD1(2) 11057576 79 36 78 29 25 28 10 6 10 0 0.86 0.96 558 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), G6PD(3), GPI(5), H6PD(4), PFKM(4), PFKP(6), PGD(2), PGLS(1), PGM1(5), PGM3(4), PRPS1(3), PRPS1L1(2), PRPS2(6), RPE(2), RPIA(7), TAL1(1), TALDO1(3), TKT(4) 7175384 77 32 75 30 23 31 12 4 7 0 0.88 0.97 559 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(1), EPO(1), EPOR(3), GRIN1(3), HIF1A(12), JAK2(14), NFKB1(7), NFKBIA(2), RELA(4), SOD2(3) 4406960 52 22 52 17 11 17 12 3 5 4 0.88 0.97 560 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(5), FUT1(3), FUT2(1), FUT9(7), GCNT2(10), ST8SIA1(1) 2206208 27 17 27 6 7 14 4 2 0 0 0.88 0.97 561 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 15 ALOX12(5), ALOX15(7), ALOX15B(5), ALOX5(6), ALOX5AP(2), GGT1(5), LTA4H(4), PLA2G6(7), PTGDS(4), PTGES(2), PTGIS(6), PTGS1(5), PTGS2(6), TBXAS1(4) 4815168 68 26 67 16 20 31 9 3 5 0 0.89 0.97 562 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(3), ARFGAP1(2), ARFGAP3(3), ARFGEF2(24), CLTB(5), COPA(11), GBF1(10), GPLD1(7), KDELR1(1), KDELR3(3) 5715408 69 27 68 20 9 35 11 5 7 2 0.89 0.97 563 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), ECHS1(2), EHHADH(4), HADHA(5), SDS(1) 4213768 37 21 36 21 12 11 4 6 4 0 0.90 0.98 564 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(6), HLCS(3), SPCS3(2) 1099880 11 8 11 8 5 1 4 0 1 0 0.90 0.98 565 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 10 ARSB(4), GLB1(4), GNS(1), GUSB(4), HEXA(1), HEXB(3), IDS(5), LCT(24), NAGLU(2) 4815168 48 25 48 23 11 22 6 5 4 0 0.90 0.98 566 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(3), ALPP(3), ALPPL2(2), DHFR(3), FPGS(3), GCH1(1), GGH(2) 2095352 19 15 19 9 4 10 2 2 1 0 0.91 0.98 567 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(3), IL22RA1(2), IL22RA2(1), JAK1(16), JAK2(14), JAK3(5), STAT1(12), STAT3(8), STAT5A(2), STAT5B(3), TYK2(4) 6542736 70 29 69 37 10 34 10 3 9 4 0.91 0.98 568 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(3) 597184 3 3 3 1 0 1 1 0 1 0 0.91 0.98 569 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1) 4730104 45 22 44 11 15 14 8 2 6 0 0.91 0.98 570 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(12), ABCC2(23), ABCG2(8), BCHE(13), CES1(11), CES2(2), CYP3A4(9), CYP3A5(4), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2) 8482344 116 34 112 33 28 46 21 11 8 2 0.91 0.98 571 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(14), CD38(5), ENPP1(8), ENPP3(14), NADSYN1(6), NMNAT1(3), NMNAT2(2), NNMT(6), NNT(6), NT5C(1), NT5E(5), NT5M(3) 5208248 73 27 71 12 15 32 16 7 3 0 0.92 0.98 572 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), GUSB(4), RPE(2), UCHL1(3), UCHL3(1), UGDH(2), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2B15(8), UGT2B4(7) 5888760 62 27 60 14 24 21 8 4 5 0 0.92 0.98 573 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(3), ALDOA(4), ALDOB(6), ALDOC(3) 1435176 16 11 15 4 3 7 3 1 2 0 0.92 0.98 574 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(3), BLVRB(1), CP(11), CPOX(4), EPRS(7), FECH(4), GUSB(4), HCCS(1), HMBS(5), HMOX1(3), HMOX2(3), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2B15(8), UGT2B4(7), UROD(1), UROS(3) 9482032 99 35 96 31 30 42 14 6 7 0 0.92 0.98 575 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 31 GTF2A1(3), GTF2A1L(2), GTF2B(3), GTF2E1(3), GTF2E2(2), GTF2F1(5), GTF2H1(6), GTF2H3(3), GTF2I(2), GTF2IRD1(6), STON1(1), TAF1(37), TAF10(1), TAF1L(30), TAF2(10), TAF4(8), TAF4B(4), TAF5(5), TAF5L(2), TAF6(6), TAF6L(4), TAF7(3), TAF7L(8), TAF9(2), TBPL1(4), TBPL2(4) 13185168 164 44 161 43 47 66 26 7 18 0 0.92 0.98 576 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(4), ACAA2(2), ACAT1(4), ACAT2(4), ECHS1(2), EHHADH(4), HADHA(5), HADHB(3), SDS(1) 2957400 29 17 29 12 7 11 7 3 1 0 0.92 0.98 577 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10(6), ALG10B(6), ALG11(4), ALG13(13), ALG14(2), ALG3(1), ALG5(2), ALG6(3), ALG8(5), ALG9(5), B4GALT1(2), B4GALT2(3), B4GALT3(6), DAD1(1), DDOST(3), DHDDS(4), DOLPP1(1), DPAGT1(2), DPM1(1), FUT8(12), GANAB(8), MAN1A1(10), MAN1A2(5), MAN1B1(3), MAN1C1(6), MAN2A1(14), MGAT1(2), MGAT2(4), MGAT3(3), MGAT4A(3), MGAT4B(5), MGAT5(7), MGAT5B(6), RFT1(4), RPN1(2), RPN2(5), ST6GAL1(6), STT3B(3) 14900832 179 50 166 47 45 74 33 6 19 2 0.92 0.98 578 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(5), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH9A1(1), AOC2(6), AOC3(9), ASPA(4), CNDP1(4), DDC(9), HAL(4), HARS(3), HDC(6), HNMT(4), MAOA(10), MAOB(5), PRPS1(3), PRPS2(6) 8900720 108 32 104 37 31 35 15 9 18 0 0.92 0.98 579 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(5), IARS(7), LARS(16), LARS2(7), PDHA1(4), PDHA2(8), PDHB(3) 3696192 50 21 49 9 9 21 6 4 10 0 0.92 0.98 580 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(4), ACAT2(4), ACYP1(2), ECHS1(2), EHHADH(4), GCDH(5), HADHA(5), SDHB(1), SDS(1) 2745856 28 17 28 14 5 13 5 3 2 0 0.93 0.98 581 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(7), CYCS(2), GPD2(3), NDUFA1(1), SDHA(10), SDHB(1), SDHC(4), UQCRC1(2) 2417256 30 16 30 7 5 17 5 2 1 0 0.93 0.98 582 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(9), KHK(1), LCT(24), MPI(3), PGM1(5), PYGL(6), PYGM(4), TREH(2) 4851624 54 22 54 29 8 23 10 6 7 0 0.93 0.98 583 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 61 ACHE(3), AGPAT2(1), AGPAT3(4), AGPAT4(3), AGPAT6(6), CDS1(4), CHAT(1), CHKA(7), CHPT1(1), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKI(16), DGKZ(8), ESCO1(8), ESCO2(5), ETNK1(8), ETNK2(1), GNPAT(6), GPAM(6), GPD1(2), GPD1L(3), GPD2(3), LCAT(2), LYPLA1(1), LYPLA2(4), NAT6(1), PCYT1A(1), PCYT1B(3), PEMT(1), PISD(2), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLD1(9), PLD2(7), PNPLA3(6), PPAP2A(4), PPAP2B(2), PTDSS1(5), SH3GLB1(6) 22378280 235 60 234 79 62 93 34 13 33 0 0.93 0.98 584 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(2), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT5(2), DDOST(3), DPAGT1(2), DPM1(1), FUT8(12), MAN1A1(10), MAN1B1(3), MGAT1(2), MGAT2(4), MGAT3(3), MGAT4A(3), MGAT4B(5), MGAT5(7), RPN1(2), RPN2(5), ST6GAL1(6) 6804624 84 30 77 21 26 32 16 2 8 0 0.93 0.98 585 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(2), EHHADH(4), HADHA(5), SDS(1) 1679952 13 10 13 14 3 4 3 3 0 0 0.93 0.98 586 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(6), GGPS1(2), IDI1(3), IDI2(1), SQLE(4) 1573808 17 11 17 5 6 6 3 1 1 0 0.93 0.98 587 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(4), FOS(2), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(3), MYC(6), NFKB1(7), NFKBIA(2), PLCB1(4), PRKCA(7), RAF1(5), RELA(4) 5586448 49 25 49 17 7 19 11 8 4 0 0.93 0.98 588 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1) 2784296 25 15 24 10 9 8 1 3 4 0 0.94 0.98 589 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1) 2784296 25 15 24 10 9 8 1 3 4 0 0.94 0.98 590 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(8), CSF1R(6), EGF(17), EGFR(10), GRB2(3), MET(9), PDGFRA(19), PRKCA(7), SH3GLB1(6), SH3GLB2(3), SH3KBP1(6), SRC(2) 7119584 96 31 93 35 21 37 20 5 11 2 0.94 0.98 591 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 CDK5(1), CDK5R1(2), DPM2(2), EGR1(6), KLK2(2), MAP2K1(2), MAPK1(2), MAPK3(3), NGFR(3), RAF1(5) 2731968 28 18 28 11 7 13 6 1 1 0 0.94 0.98 592 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 BPNT1(1), CHST11(7), CHST12(3), PAPSS1(5), PAPSS2(5), SULT1A1(4), SULT1A2(1), SULT1E1(9), SULT2A1(6), SULT2B1(2) 3294928 43 19 39 17 11 24 5 1 2 0 0.94 0.98 593 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(4), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB2(2), PSMB3(1), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(1), PSMC2(2), PSMD1(8), PSMD11(3), PSMD12(4), PSMD13(1), PSMD2(6), PSMD6(1) 5803696 53 25 50 21 11 20 8 2 12 0 0.95 0.98 594 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), CDK5R1(2), DAB1(4), FYN(6), LRP8(3), RELN(36), VLDLR(3) 5183200 55 25 53 19 17 19 10 2 5 2 0.95 0.98 595 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(3), SRP19(3), SRP54(7), SRP68(4), SRP72(6), SRP9(1), SRPR(9) 2741144 34 16 34 8 10 14 2 3 5 0 0.95 0.98 596 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 12 AKR1A1(1), ECHS1(2), EHHADH(4), HADH(1), HADHA(5), HSD17B10(2), HSD17B4(8), NTAN1(3), SIRT1(4), SIRT2(4), SIRT5(1), VNN2(8) 4042400 43 20 41 18 7 21 9 4 2 0 0.95 0.98 597 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(4), ACAT2(4), ACOT11(4), ACYP1(2), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), ECHS1(2), EHHADH(4), ESCO1(8), ESCO2(5), GCDH(5), HADHA(5), NAT6(1), PNPLA3(6), SH3GLB1(6), YOD1(2) 9325296 72 34 72 24 17 29 12 4 10 0 0.95 0.98 598 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), GUSB(4), RPE(2), UGDH(2), UGP2(5), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3), XYLB(5) 9133840 125 33 118 26 42 48 19 7 9 0 0.96 0.99 599 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1C1(3), AKR1C2(3), AKR1C3(2), AKR1C4(5), ALDH3A1(2), ALDH3B2(5), CYP1A1(9), CYP1A2(5), CYP1B1(1), CYP2B6(11), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2E1(1), CYP2F1(3), CYP2S1(6), CYP3A4(9), CYP3A43(3), CYP3A5(4), CYP3A7(6), DHDH(2), EPHX1(1), GSTA1(2), GSTA2(4), GSTA3(2), GSTA4(3), GSTA5(3), GSTK1(3), GSTM1(2), GSTM2(1), GSTM3(4), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(4), MGST1(4), MGST3(1), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3) 20205800 274 56 265 64 80 108 45 16 25 0 0.97 0.99 600 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(14), BST1(1), CD38(5), ENPP1(8), ENPP3(14), NADK(4), NADSYN1(6), NMNAT1(3), NMNAT2(2), NNMT(6), NNT(6), NT5C(1), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(8), NT5E(5), NT5M(3), NUDT12(2) 7702136 99 31 96 27 23 40 21 11 4 0 0.97 0.99 601 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(6), AASDH(7), AASDHPPT(4), AASS(6), ACAT1(4), ACAT2(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), ATP6V0C(1), DLST(8), DOT1L(5), ECHS1(2), EHHADH(4), EHMT2(1), GCDH(5), HADHA(5), PLOD1(3), PLOD2(13), PLOD3(6), SDS(1), SHMT1(4), SHMT2(2), TMLHE(4) 12466216 120 40 118 43 34 39 20 10 15 2 0.97 0.99 602 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(1), CHKA(7), PCYT1A(1), PDHA1(4), PDHA2(8), PEMT(1) 2469336 25 14 25 10 9 5 5 2 4 0 0.97 0.99 603 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(5), BCAT2(3), IARS(7), IARS2(13), ILVBL(7), LARS(16), LARS2(7), PDHA1(4), PDHA2(8), PDHB(3), VARS(4) 6785032 77 27 75 18 15 37 7 6 12 0 0.97 0.99 604 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(5), CYP2E1(1), NR1I3(5), PTGS1(5), PTGS2(6) 1944320 22 13 22 6 7 8 3 1 3 0 0.98 0.99 605 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(4), ABP1(5), AOC2(6), AOC3(9), CES1(11), DDHD1(10), ESCO1(8), ESCO2(5), LIPA(5), NAT6(1), PLA1A(3), PNPLA3(6), PPME1(1), PRDX6(2), SH3GLB1(6) 9327776 82 31 78 32 23 23 17 5 12 2 0.98 0.99 606 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(8), CYP51A1(3), DHCR24(5), DHCR7(2), FDFT1(1), FDPS(6), GGCX(7), GGPS1(2), HMGCR(9), HSD17B7(3), IDI1(3), IDI2(1), MVD(3), MVK(3), NQO1(3), NSDHL(9), PMVK(2), SC5DL(2), SQLE(4), TM7SF2(1), VKORC1(1) 6542488 78 24 77 40 28 29 10 4 7 0 0.98 0.99 607 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(3), ALAS1(5), ALAS2(10), BLVRB(1), COX10(1), COX15(3), CP(11), CPOX(4), EARS2(3), EPRS(7), FECH(4), FTH1(2), FTMT(5), GUSB(4), HCCS(1), HMBS(5), HMOX1(3), HMOX2(3), MMAB(1), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3), UROD(1), UROS(3) 14519408 186 42 178 51 55 79 29 11 12 0 0.98 0.99 608 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL5(2), CCR3(4), IL5(1) 1124184 7 6 7 1 0 4 2 0 1 0 0.98 1.00 609 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS1(5), PAPSS2(5), SULT1A2(1), SULT1E1(9), SULT2A1(6) 2261760 27 13 24 10 6 15 3 1 2 0 0.99 1.00 610 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(16), EGF(17), EGFR(10), RAB5A(1), TF(12), TFRC(3) 4653968 59 22 57 15 13 24 10 2 10 0 0.99 1.00 611 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(4), ACAD9(8), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), ESCO1(8), ESCO2(5), NAT6(1), PNPLA3(6), SH3GLB1(6) 9099864 84 28 84 18 22 31 15 0 14 2 0.99 1.00 612 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(3), B3GALT5(4), FUT1(3), FUT2(1), FUT9(7), GBGT1(5), GLA(2), HEXA(1), HEXB(3), NAGA(2), ST3GAL1(1), ST3GAL2(3), ST8SIA1(1) 3688256 36 18 34 15 10 16 5 2 3 0 0.99 1.00 613 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), ESCO1(8), ESCO2(5), NAT6(1), PNPLA3(6), SH3GLB1(6) 6008296 40 22 40 9 11 16 6 0 7 0 1.00 1.00 614 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), UGDH(2) 2853240 15 12 14 7 7 4 0 2 2 0 1.00 1.00 615 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(3), FUT2(1), FUT9(7), GBGT1(5), GLA(2), HEXA(1), HEXB(3), NAGA(2), ST3GAL1(1), ST3GAL2(3), ST3GAL4(3), ST8SIA1(1) 3458360 32 16 32 13 9 14 7 2 0 0 1.00 1.00 616 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 40 ALPI(2), ALPL(3), ALPP(3), ALPPL2(2), ASCC3(25), ATP13A2(4), DDX18(10), DDX19A(1), DDX23(8), DDX4(13), DDX41(1), DDX47(4), DDX50(8), DDX52(5), DDX54(6), DDX55(5), DDX56(4), DHFR(3), DHX58(5), ENTPD7(6), ERCC2(1), ERCC3(8), FPGS(3), GCH1(1), GGH(2), IFIH1(3), NUDT5(1), NUDT8(1), PTS(1), RAD54B(12), RAD54L(3), RUVBL2(4), SETX(29), SKIV2L2(15), SMARCA2(18), SMARCA5(14) 22054640 234 51 223 66 57 84 45 16 25 7 1.00 1.00