rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	217	ADCYAP1R1(5), ADORA1(3), ADORA2A(4), ADORA2B(1), ADORA3(3), ADRA1A(8), ADRA1B(5), ADRA2B(6), ADRB1(1), ADRB2(5), AGTR1(1), AGTR2(7), AVPR1A(7), AVPR1B(2), AVPR2(4), BDKRB1(2), BDKRB2(7), C3AR1(7), C5AR1(3), CALCR(4), CALCRL(7), CCKAR(9), CCKBR(3), CGA(1), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), CNR1(6), CNR2(3), CRHR1(2), CRHR2(1), CTSG(3), CYSLTR1(6), CYSLTR2(3), DRD1(5), DRD2(6), DRD3(4), DRD5(8), EDNRA(5), F2(8), F2R(6), F2RL1(2), F2RL2(2), FPR1(1), FSHR(14), GABBR1(8), GABBR2(13), GABRA1(8), GABRA2(10), GABRA3(12), GABRA4(12), GABRA5(6), GABRA6(6), GABRB1(7), GABRB2(12), GABRB3(9), GABRE(5), GABRG1(6), GABRG2(14), GABRG3(7), GABRP(3), GABRQ(5), GABRR1(3), GALR1(2), GALR3(2), GH1(2), GH2(2), GHR(8), GHRHR(1), GHSR(7), GIPR(3), GLP1R(5), GLP2R(8), GLRA1(6), GLRA2(6), GLRA3(8), GLRB(6), GNRHR(3), GPR156(4), GPR50(4), GPR63(4), GPR83(2), GRIA1(11), GRIA2(17), GRIA3(18), GRIA4(15), GRID1(7), GRID2(9), GRIK1(10), GRIK2(10), GRIK3(13), GRIK4(3), GRIK5(15), GRIN1(3), GRIN2A(18), GRIN2B(18), GRIN2C(5), GRIN2D(5), GRIN3A(12), GRM1(18), GRM2(5), GRM3(14), GRM4(12), GRM5(19), GRM6(9), GRM7(10), GRM8(17), GRPR(3), GZMA(6), HCRTR2(6), HRH1(9), HRH2(3), HRH4(4), HTR1A(11), HTR1B(4), HTR1D(5), HTR1E(5), HTR1F(10), HTR2A(9), HTR2B(2), HTR2C(13), HTR4(5), HTR5A(7), HTR6(3), HTR7(3), LEP(1), LEPR(10), LHB(2), LHCGR(14), LTB4R(2), LTB4R2(3), MAS1(1), MC2R(1), MC3R(5), MC4R(3), MC5R(8), MCHR1(7), MCHR2(1), MLNR(2), MTNR1A(4), MTNR1B(3), NMBR(3), NMUR1(4), NMUR2(6), NPFFR1(2), NPFFR2(9), NPY1R(3), NPY2R(3), NPY5R(7), NR3C1(11), NTSR1(4), NTSR2(1), OPRK1(6), OPRM1(8), OXTR(4), P2RX1(4), P2RX3(7), P2RX4(1), P2RX5(5), P2RX7(1), P2RY1(2), P2RY10(5), P2RY11(8), P2RY13(1), P2RY14(3), P2RY2(3), P2RY4(5), P2RY6(3), PARD3(19), PPYR1(6), PRL(4), PRLHR(1), PRLR(3), PRSS1(4), PRSS3(2), PTAFR(4), PTGDR(6), PTGER2(2), PTGER3(7), PTGER4(7), PTGFR(9), PTGIR(2), PTH2R(8), RXFP1(15), RXFP2(11), SCTR(3), SSTR2(2), SSTR3(3), TAAR1(6), TAAR2(4), TAAR5(5), TAAR6(4), TAAR8(2), TAAR9(6), TACR1(5), TACR2(2), TACR3(8), THRA(4), THRB(2), TRHR(2), TRPV1(3), TSHB(3), TSHR(7), VIPR1(2)	75157640	1220	150	1178	439	372	500	187	51	108	2	2.27e-09	1.40e-06
2	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	162	ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY7(5), ADCY8(15), ADCY9(17), ADORA2A(4), ADORA2B(1), ADRA1A(8), ADRA1B(5), ADRB1(1), ADRB2(5), AGTR1(1), ATP2A1(9), ATP2A2(6), ATP2A3(9), ATP2B1(14), ATP2B2(8), ATP2B3(14), ATP2B4(13), AVPR1A(7), AVPR1B(2), BDKRB1(2), BDKRB2(7), BST1(1), CACNA1A(15), CACNA1C(21), CACNA1D(23), CACNA1E(40), CACNA1F(30), CACNA1G(16), CACNA1I(5), CACNA1S(22), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), CCKAR(9), CCKBR(3), CD38(5), CHRM1(3), CHRM2(8), CHRM3(6), CHRM5(8), CHRNA7(4), CYSLTR1(6), CYSLTR2(3), DRD1(5), EDNRA(5), EGFR(10), ERBB2(3), ERBB3(14), ERBB4(19), F2R(6), GNA11(2), GNA14(5), GNA15(1), GNAL(6), GNAS(16), GRIN1(3), GRIN2A(18), GRIN2C(5), GRIN2D(5), GRM1(18), GRM5(19), GRPR(3), HRH1(9), HRH2(3), HTR2A(9), HTR2B(2), HTR2C(13), HTR4(5), HTR5A(7), HTR6(3), HTR7(3), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), LHCGR(14), LTB4R2(3), MYLK(10), MYLK2(6), NOS1(14), NOS3(6), NTSR1(4), OXTR(4), P2RX1(4), P2RX3(7), P2RX4(1), P2RX5(5), P2RX7(1), PDE1A(10), PDE1B(6), PDE1C(10), PDGFRA(19), PDGFRB(10), PHKA1(13), PHKA2(12), PHKB(10), PHKG1(5), PHKG2(2), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(3), PLCD4(10), PLCE1(31), PLCG1(8), PLCG2(23), PLCZ1(11), PLN(1), PPID(2), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), PTAFR(4), PTGER3(7), PTGFR(9), PTK2B(13), RYR1(59), RYR3(65), SLC25A4(2), SLC25A5(1), SLC25A6(4), SLC8A1(9), SLC8A2(3), SLC8A3(9), SPHK1(2), SPHK2(1), TACR1(5), TACR2(2), TACR3(8), TNNC1(2), TNNC2(3), TRHR(2), TRPC1(12), VDAC1(2), VDAC2(1), VDAC3(2)	91768680	1296	144	1262	481	375	527	180	64	140	10	1.20e-06	0.00030
3	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	226	ACVR1B(5), ACVR1C(3), AKT1(3), AKT2(4), AKT3(7), ARRB1(4), ARRB2(3), ATF2(6), ATF4(3), BDNF(6), BRAF(9), CACNA1A(15), CACNA1C(21), CACNA1D(23), CACNA1E(40), CACNA1F(30), CACNA1G(16), CACNA1I(5), CACNA1S(22), CACNA2D1(9), CACNA2D2(8), CACNA2D3(17), CACNA2D4(13), CACNB1(7), CACNB2(9), CACNB3(4), CACNB4(11), CACNG2(2), CACNG3(8), CACNG4(6), CACNG5(4), CACNG6(4), CACNG7(7), CASP3(3), CD14(2), CDC25B(2), CDC42(4), CHUK(7), CRK(1), CRKL(4), DAXX(6), DDIT3(1), DUSP1(2), DUSP10(5), DUSP14(3), DUSP16(8), DUSP3(1), DUSP5(3), DUSP6(1), DUSP7(3), DUSP9(1), ECSIT(3), EGF(17), EGFR(10), ELK1(2), ELK4(2), FAS(6), FASLG(5), FGF10(1), FGF11(1), FGF12(2), FGF13(4), FGF14(3), FGF18(1), FGF21(1), FGF23(3), FGF5(6), FGF6(1), FGF7(4), FGF8(1), FGF9(1), FGFR1(7), FGFR4(8), FLNA(27), FLNB(28), FLNC(27), FOS(2), GNA12(7), GNG12(1), GRB2(3), IKBKB(8), IL1B(2), IL1R1(4), IL1R2(5), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K5(2), MAP2K6(6), MAP3K1(24), MAP3K10(6), MAP3K12(6), MAP3K13(11), MAP3K14(4), MAP3K2(8), MAP3K3(6), MAP3K4(16), MAP3K5(19), MAP3K6(4), MAP3K7(8), MAP3K8(6), MAP4K1(9), MAP4K2(6), MAP4K3(14), MAP4K4(7), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK7(11), MAPK8(7), MAPK8IP1(4), MAPK9(4), MAPKAPK2(4), MAPKAPK3(2), MAPKAPK5(4), MAPT(9), MAX(4), MEF2C(8), MKNK1(3), MKNK2(3), MOS(6), MRAS(1), MYC(6), NF1(30), NFATC2(9), NFATC4(7), NFKB1(7), NFKB2(9), NLK(5), NR4A1(4), NTF3(4), NTRK1(11), NTRK2(11), PAK1(1), PAK2(3), PDGFB(2), PDGFRA(19), PDGFRB(10), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PPM1A(6), PPM1B(3), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PPP5C(4), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), PTPN5(4), PTPN7(4), PTPRR(13), RAC1(1), RAC2(2), RAF1(5), RAP1A(3), RAP1B(2), RAPGEF2(26), RASA2(7), RASGRF1(8), RASGRF2(11), RASGRP1(6), RASGRP2(2), RASGRP3(5), RASGRP4(5), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA4(1), RPS6KA5(7), RPS6KA6(12), RRAS(1), RRAS2(4), SOS1(10), SOS2(16), SRF(2), STK3(7), STK4(5), STMN1(4), TAOK1(9), TAOK2(6), TAOK3(3), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), TNFRSF1A(4), TRAF2(2), TRAF6(3), ZAK(11)	96983624	1341	145	1309	424	361	537	161	89	175	18	1.48e-06	0.00030
4	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	37	ADAM17(8), CREBBP(24), CTBP2(5), DLL1(6), DLL3(5), DLL4(2), DTX1(5), DTX2(2), DTX3(4), DTX3L(4), DTX4(4), DVL2(5), DVL3(7), EP300(23), HDAC1(3), HDAC2(4), HES1(1), JAG1(13), MAML1(6), MAML2(5), MAML3(14), MFNG(3), NCOR2(16), NCSTN(7), NOTCH2(9), NOTCH3(20), NOTCH4(10), NUMB(7), NUMBL(3), PSEN1(5), PSEN2(3), RBPJ(4), RBPJL(7), SNW1(5)	20548784	249	80	243	77	59	106	26	12	42	4	0.000014	0.0022
5	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	132	ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ADRA1A(8), ADRA1B(5), ADRB1(1), ADRB2(5), ANXA6(8), ARRB1(4), ARRB2(3), ATP1A4(19), ATP1B1(3), ATP1B2(4), ATP1B3(2), ATP2A2(6), ATP2A3(9), ATP2B1(14), ATP2B2(8), ATP2B3(14), CACNA1A(15), CACNA1C(21), CACNA1D(23), CACNA1E(40), CACNA1S(22), CACNB1(7), CACNB3(4), CALM2(3), CALR(1), CAMK1(2), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), CASQ1(4), CASQ2(6), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), GJA1(5), GJA4(1), GJB1(1), GJB2(2), GJB3(2), GJB4(3), GJB5(2), GJB6(3), GNA11(2), GNAI2(4), GNAI3(3), GNAO1(4), GNAZ(4), GNB1(1), GNB2(6), GNB4(3), GNB5(1), GNG12(1), GNG2(2), GNG3(2), GRK4(9), GRK5(8), GRK6(2), ITPR1(23), ITPR2(25), ITPR3(15), KCNB1(11), KCNJ3(9), KCNJ5(5), MIB1(6), MYCBP(1), NME7(2), PEA15(2), PLCB3(9), PLN(1), PRKACA(4), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCQ(6), PRKCZ(3), PRKD1(6), RGS1(4), RGS10(2), RGS14(4), RGS16(3), RGS17(3), RGS18(2), RGS2(2), RGS20(1), RGS3(8), RGS4(6), RGS5(4), RGS6(6), RGS7(6), RGS9(10), RYR1(59), RYR3(65), SLC8A1(9), SLC8A3(9), USP5(11), YWHAH(2), YWHAQ(1)	64487192	862	126	840	312	244	360	103	42	107	6	0.000040	0.0050
6	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	18	APC(36), AXIN1(7), BTRC(11), CREBBP(24), CSNK1A1(4), CSNK2A1(7), FZD1(3), GSK3B(8), HDAC1(3), MAP3K7(8), MYC(6), NLK(5), PPARD(3), PPP2CA(4), TLE1(8), WIF1(4), WNT1(1)	8945360	142	59	139	26	38	54	15	7	22	6	0.000059	0.0061
7	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(3), EIF4A1(4), EIF4A2(4), EIF4B(5), EIF4E(2), EIF4G1(10), EIF4G2(6), EIF4G3(18), MKNK1(3), PDK2(3), PDPK1(2), PPP2CA(4), RPS6(6), RPS6KB1(2), TSC1(9), TSC2(13)	7641128	94	52	94	24	22	38	11	7	16	0	0.00020	0.017
8	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	188	ABI2(1), ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), APC(36), ARAF(8), ARHGEF1(9), ARHGEF12(19), ARHGEF4(5), ARHGEF6(16), ARHGEF7(11), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), ARPC5(1), BDKRB1(2), BDKRB2(7), BRAF(9), CD14(2), CDC42(4), CFL1(1), CFL2(7), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), CRK(1), CRKL(4), CSK(1), CYFIP1(7), CYFIP2(17), DIAPH1(10), DIAPH2(18), DIAPH3(24), DOCK1(17), EGF(17), EGFR(10), EZR(4), F2(8), F2R(6), FGD1(10), FGD3(8), FGF10(1), FGF11(1), FGF12(2), FGF13(4), FGF14(3), FGF18(1), FGF21(1), FGF23(3), FGF5(6), FGF6(1), FGF7(4), FGF8(1), FGF9(1), FGFR1(7), FGFR4(8), FN1(31), GIT1(8), GNA12(7), GNA13(7), GNG12(1), GSN(4), IQGAP1(9), IQGAP2(21), IQGAP3(15), ITGA1(13), ITGA10(7), ITGA11(6), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGAD(5), ITGAE(7), ITGAL(12), ITGAM(19), ITGAV(6), ITGAX(7), ITGB1(5), ITGB2(10), ITGB3(10), ITGB4(6), ITGB5(4), ITGB6(4), ITGB7(4), ITGB8(4), LIMK1(6), LIMK2(10), MAP2K1(2), MAPK1(2), MAPK3(3), MOS(6), MRAS(1), MSN(12), MYH10(23), MYH14(17), MYH9(18), MYL2(1), MYL5(1), MYL7(3), MYL9(3), MYLK(10), MYLK2(6), MYLPF(2), NCKAP1(6), NCKAP1L(13), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PDGFB(2), PDGFRA(19), PDGFRB(10), PFN1(1), PFN2(1), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PIP4K2A(2), PIP4K2B(7), PIP4K2C(3), PIP5K1A(6), PIP5K1B(3), PIP5K1C(4), PPP1CA(3), PPP1CB(4), PPP1CC(2), PPP1R12A(8), PPP1R12B(11), PTK2(8), PXN(4), RAC1(1), RAC2(2), RAF1(5), RDX(11), RHOA(3), ROCK1(15), ROCK2(10), RRAS(1), RRAS2(4), SCIN(3), SLC9A1(6), SOS1(10), SOS2(16), SSH1(10), SSH2(7), SSH3(3), TIAM1(20), TIAM2(14), VAV1(10), VAV2(3), VAV3(9), VCL(8), WAS(8), WASF1(3), WASF2(3), WASL(7)	94119720	1251	138	1222	418	327	498	173	69	166	18	0.00051	0.039
9	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	ATF2(6), CDC42(4), CREB1(5), DAXX(6), DDIT3(1), ELK1(2), GRB2(3), HMGN1(1), HSPB2(1), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K5(19), MAP3K7(8), MAP3K9(3), MAPK14(4), MAPKAPK2(4), MAPKAPK5(4), MAX(4), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), MKNK1(3), MYC(6), PLA2G4A(9), RAC1(1), RIPK1(8), RPS6KA5(7), SHC1(5), STAT1(12), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TRAF2(2)	13175992	197	66	193	50	45	91	20	12	27	2	0.00072	0.049
10	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(36), CDH1(12), CREBBP(24), EP300(23), MAP2K1(2), MAP3K7(8), MAPK3(3), SKIL(7), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6)	9292808	139	56	135	37	26	59	19	8	23	4	0.0010	0.062
11	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	23	ATF1(4), CASP2(4), CHUK(7), CRADD(2), IKBKB(8), JUN(1), LTA(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K14(4), MAP4K2(6), MAPK14(4), MAPK8(7), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), TANK(2), TNFRSF1A(4), TRAF2(2)	8353136	119	47	118	29	19	46	17	14	21	2	0.0012	0.067
12	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(8), GABRA2(10), GABRA3(12), GABRA4(12), GABRA5(6), GABRA6(6), PRKCE(7), SOD1(2)	2907552	63	33	58	21	19	22	8	4	10	0	0.0017	0.087
13	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(3), DPM2(2), GRB2(3), KLK2(2), NTRK1(11), PLCG1(8), PRKCA(7), SHC1(5), SOS1(10)	4277752	51	37	48	20	14	24	6	5	2	0	0.0020	0.087
14	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	119	ACACA(27), ACACB(25), AKT1(3), AKT2(4), AKT3(7), ARAF(8), BAD(2), BRAF(9), CALM2(3), CALML6(3), CBL(8), CBLB(11), CBLC(4), CRK(1), CRKL(4), ELK1(2), EXOC7(3), FBP1(2), FLOT2(1), FOXO1(9), G6PC(5), G6PC2(4), GCK(3), GRB2(3), GSK3B(8), GYS1(9), GYS2(14), IKBKB(8), INPP5D(9), INSR(12), IRS1(10), IRS4(16), LIPE(7), MAP2K1(2), MAPK1(2), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(4), MKNK1(3), MKNK2(3), PCK1(8), PCK2(7), PDE3A(14), PDE3B(9), PDPK1(2), PFKM(4), PFKP(6), PHKA1(13), PHKA2(12), PHKB(10), PHKG1(5), PHKG2(2), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PKLR(5), PKM2(4), PPARGC1A(8), PPP1CA(3), PPP1CB(4), PPP1CC(2), PPP1R3A(17), PPP1R3B(2), PPP1R3C(3), PRKAA1(5), PRKAA2(7), PRKAB1(6), PRKAB2(1), PRKACA(4), PRKACG(7), PRKAG1(2), PRKAG2(3), PRKAG3(5), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCI(6), PRKCZ(3), PRKX(2), PTPN1(4), PTPRF(19), PYGB(9), PYGL(6), PYGM(4), RAF1(5), RAPGEF1(9), RHEB(2), RHOQ(1), RPS6(6), RPS6KB1(2), RPS6KB2(4), SH2B2(1), SHC1(5), SHC3(9), SHC4(5), SLC2A4(5), SOCS2(6), SOCS4(3), SORBS1(14), SOS1(10), SOS2(16), SREBF1(2), TRIP10(6), TSC1(9), TSC2(13)	51082544	714	119	695	217	187	286	106	26	101	8	0.0021	0.087
15	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	11	APC(36), AXIN1(7), CREBBP(24), EP300(23), FZD1(3), GSK3B(8), HDAC1(3), LDB1(2), LEF1(8), TRRAP(32), WNT1(1)	10507760	147	57	144	49	33	51	20	8	29	6	0.0021	0.087
16	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	26	CALM2(3), CRKL(4), GRB2(3), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP3K1(24), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(7), PAK1(1), PLCG1(8), PRKCA(7), PTK2B(13), RAC1(1), RAF1(5), SHC1(5), SOS1(10), SRC(2), SYT1(4)	9544280	120	54	116	39	32	42	15	13	16	2	0.0029	0.11
17	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	11	AKT1(3), GRB2(3), ILK(4), ITGB1(5), MAPK1(2), MAPK3(3), PDK2(3), PDPK1(2), PTK2(8), SHC1(5), SOS1(10)	4749696	48	35	46	16	8	19	10	4	7	0	0.0035	0.13
18	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(3), CREB1(5), GRB2(3), MAPK1(2), MAPK3(3), MAPK7(11), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), NTRK1(11), PLCG1(8), RPS6KA1(1), SHC1(5)	5382840	69	42	68	22	16	35	7	4	7	0	0.0042	0.14
19	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(4), CD34(1), CD3D(3), CD3E(1), CD3G(1), CD4(6), CD58(1), CD8A(2), CSF3(1), IL6(4), IL8(3), KITLG(2)	2280856	29	24	29	7	4	13	4	0	8	0	0.0046	0.15
20	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(3), CD3D(3), CD3E(1), CD3G(1), CD4(6), ICAM1(1), ITGAL(12), ITGB2(10), PTPRC(11), THY1(1)	4000984	53	33	53	18	11	25	6	1	10	0	0.0063	0.18
21	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CD28(3), CD3D(3), CD3E(1), CD3G(1), CD4(6)	941904	14	14	14	5	1	7	1	0	5	0	0.0064	0.18
22	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	CHUK(7), IFNB1(2), IKBKB(8), IL1B(2), IL1R1(4), IL1RAP(5), IL6(4), IRAK1(4), IRAK2(5), IRAK3(7), JUN(1), MAP2K3(7), MAP2K6(6), MAP3K1(24), MAP3K14(4), MAP3K7(8), MAPK14(4), MAPK8(7), MYD88(1), NFKB1(7), NFKBIA(2), RELA(4), TGFB1(2), TGFB2(5), TGFB3(8), TRAF6(3)	10439560	141	52	138	32	29	54	22	11	23	2	0.0067	0.18
23	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	145	ADORA1(3), ADORA2A(4), ADORA2B(1), ADORA3(3), ADRA1A(8), ADRA1B(5), ADRB1(1), ADRB2(5), AGTR1(1), AGTR2(7), AVPR1A(7), AVPR1B(2), AVPR2(4), BDKRB1(2), BDKRB2(7), C3AR1(7), CCBP2(3), CCKAR(9), CCKBR(3), CCR1(3), CCR2(4), CCR3(4), CCR4(2), CCR6(5), CCR7(6), CCR8(5), CCR9(1), CCRL1(4), CHML(5), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), CMKLR1(8), CNR1(6), CNR2(3), CX3CR1(4), CXCR3(5), CXCR4(1), DRD1(5), DRD2(6), DRD3(4), DRD5(8), EDNRA(5), F2R(6), F2RL1(2), F2RL2(2), FPR1(1), FSHR(14), GALR1(2), GALR3(2), GALT(2), GHSR(7), GNB2L1(1), GPR17(3), GPR174(9), GPR3(5), GPR37(7), GPR37L1(4), GPR4(8), GPR50(4), GPR6(4), GPR63(4), GPR77(1), GPR83(2), GPR85(4), GPR87(5), GRPR(3), HCRTR2(6), HRH1(9), HRH2(3), HTR1A(11), HTR1B(4), HTR1D(5), HTR1E(5), HTR1F(10), HTR2A(9), HTR2B(2), HTR2C(13), HTR4(5), HTR5A(7), HTR6(3), HTR7(3), LHCGR(14), LTB4R(2), MAS1(1), MC3R(5), MC4R(3), MC5R(8), MLNR(2), MTNR1A(4), MTNR1B(3), NMBR(3), NMUR1(4), NMUR2(6), NPY1R(3), NPY2R(3), NPY5R(7), NTSR1(4), NTSR2(1), OPN1SW(6), OPN3(1), OPRK1(6), OPRM1(8), OR10A5(3), OR12D3(6), OR1F1(3), OR1Q1(3), OR2H1(1), OR5V1(7), OR7A5(4), OR7C1(6), OR8B8(3), OXTR(4), P2RY1(2), P2RY10(5), P2RY11(8), P2RY12(2), P2RY13(1), P2RY14(3), P2RY2(3), P2RY6(3), PPYR1(6), PTAFR(4), PTGDR(6), PTGER2(2), PTGER4(7), PTGFR(9), PTGIR(2), RGR(5), RHO(3), RRH(2), SSTR2(2), SSTR3(3), SUCNR1(1), TRHR(2)	39656936	619	102	601	221	187	269	86	28	49	0	0.0069	0.18
24	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(6), CD8A(2), CSF1(3), CSF3(1), EPO(1), IL2(2), IL5(1), IL6(4), IL7(1), IL8(3)	2205464	24	22	24	10	8	9	3	0	4	0	0.0072	0.18
25	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(3), EIF4A1(4), EIF4A2(4), EIF4E(2), EIF4G1(10), EIF4G2(6), EIF4G3(18), GHR(8), IRS1(10), MAPK1(2), MAPK14(4), MAPK3(3), MKNK1(3), PABPC1(8), PDK2(3), PDPK1(2), PRKCA(7), RPS6KB1(2)	8574600	99	46	99	28	19	33	20	10	17	0	0.0075	0.18
26	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	131	APC(36), AXIN1(7), BTRC(11), CACYBP(2), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CCND2(7), CCND3(3), CER1(2), CHD8(30), CREBBP(24), CSNK1A1(4), CSNK1A1L(2), CSNK1E(3), CSNK2A1(7), CSNK2A2(3), CTBP2(5), CUL1(12), DAAM1(14), DAAM2(6), DKK1(3), DKK2(3), DKK4(3), DVL2(5), DVL3(7), EP300(23), FBXW11(4), FOSL1(3), FZD1(3), FZD10(6), FZD2(5), FZD3(5), FZD4(4), FZD6(11), FZD7(4), FZD9(5), GSK3B(8), JUN(1), LEF1(8), LRP5(12), LRP6(16), MAP3K7(8), MAPK10(7), MAPK8(7), MAPK9(4), MYC(6), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NKD1(3), NLK(5), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PORCN(10), PPARD(3), PPP2CA(4), PPP2CB(2), PPP2R1B(5), PPP2R2A(10), PPP2R2B(7), PPP2R2C(2), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRICKLE1(5), PRICKLE2(2), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), PSEN1(5), RAC1(1), RAC2(2), RBX1(1), RHOA(3), ROCK1(15), ROCK2(10), RUVBL1(1), SENP2(6), SFRP1(5), SFRP2(2), SFRP4(9), SFRP5(2), SIAH1(3), SMAD2(7), SMAD3(5), SMAD4(3), TBL1X(5), TBL1XR1(11), TCF7(3), TCF7L1(2), TCF7L2(10), VANGL1(4), VANGL2(6), WIF1(4), WNT1(1), WNT10A(1), WNT10B(1), WNT11(3), WNT16(4), WNT2(2), WNT2B(7), WNT3(3), WNT4(1), WNT5A(4), WNT5B(3), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(3), WNT9A(1), WNT9B(1)	53045960	694	110	679	215	189	279	90	37	89	10	0.0082	0.19
27	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	61	APAF1(11), BAD(2), BAK1(3), BAX(3), BCL2L1(3), BCL2L11(5), BID(2), BIRC2(10), BIRC3(2), BIRC5(4), BNIP3L(1), CASP1(5), CASP10(8), CASP2(4), CASP3(3), CASP4(5), CASP6(3), CASP7(4), CASP9(2), CHUK(7), CYCS(2), DFFB(3), FAS(6), FASLG(5), GZMB(2), HELLS(8), IKBKB(8), IRF1(1), IRF2(6), IRF3(2), IRF4(6), IRF5(5), IRF6(7), JUN(1), LTA(2), MAP2K4(4), MAP3K1(24), MAPK10(7), MDM2(3), MYC(6), NFKB1(7), NFKBIA(2), NFKBIE(5), PLEKHG5(5), PRF1(6), RELA(4), RIPK1(8), TNFRSF10B(4), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TRAF1(5), TRAF2(2), TRAF3(4)	18957120	257	66	251	67	60	100	31	17	45	4	0.0092	0.19
28	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	29	ACVR1(9), APC(36), ATF2(6), AXIN1(7), BMP10(7), BMP2(5), BMP4(7), BMP5(12), BMP7(10), BMPR1A(4), BMPR2(9), CHRD(8), FZD1(3), GATA4(1), GSK3B(8), MAP3K7(8), MEF2C(8), MYL2(1), NOG(2), NPPA(1), NPPB(2), RFC1(13), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), TGFBR3(8), WNT1(1)	11754952	200	60	195	39	53	87	24	7	25	4	0.0095	0.19
29	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	89	ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ATF4(3), CACNA1C(21), CACNA1D(23), CACNA1F(30), CACNA1S(22), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CDC42(4), CGA(1), EGFR(10), ELK1(2), GNA11(2), GNAS(16), GNRH1(1), GNRH2(1), GNRHR(3), GRB2(3), HBEGF(2), ITPR1(23), ITPR2(25), ITPR3(15), JUN(1), LHB(2), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K2(8), MAP3K3(6), MAP3K4(16), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK7(11), MAPK8(7), MAPK9(4), MMP14(3), MMP2(6), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLD1(9), PLD2(7), PRKACA(4), PRKACG(7), PRKCA(7), PRKCD(4), PRKX(2), PTK2B(13), RAF1(5), SOS1(10), SOS2(16), SRC(2)	44860224	595	105	581	195	164	244	74	29	72	12	0.0098	0.19
30	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	48	ADORA3(3), ALG6(3), CCKBR(3), CCR2(4), CCR3(4), CELSR2(18), CELSR3(18), CHRM2(8), CHRM3(6), CIDEB(2), CXCR3(5), EDNRA(5), EMR2(3), EMR3(3), F2R(6), FSHR(14), GHRHR(1), GNRHR(3), GPR116(15), GPR132(6), GPR133(11), GPR143(4), GPR17(3), GPR18(1), GPR55(2), GPR56(2), GPR61(2), GPR77(1), GPR84(3), GRM1(18), GRPR(3), HRH4(4), LGR6(13), LPHN2(19), LPHN3(14), LTB4R2(3), NTSR1(4), OR8G2(5), P2RY11(8), P2RY13(1), PTGFR(9), SMO(5), SSTR2(2), TAAR5(5), TSHR(7), VN1R1(4)	21046272	283	74	280	98	85	113	37	16	32	0	0.0099	0.19
31	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(3), BTK(4), CALM2(3), CD79B(2), ELK1(2), FOS(2), GRB2(3), JUN(1), LYN(6), MAP2K1(2), MAP3K1(24), MAPK14(4), MAPK3(3), MAPK8(7), NFATC2(9), NFATC3(9), NFATC4(7), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKCA(7), RAC1(1), RAF1(5), SHC1(5), SOS1(10), SYK(3), SYT1(4), VAV1(10)	13570808	155	61	150	48	51	43	23	14	22	2	0.0099	0.19
32	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	106	ADA(2), ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADK(1), ADSL(5), ADSS(6), AK2(2), AK5(5), ALLC(7), AMPD1(17), AMPD2(6), AMPD3(4), ATIC(6), ATP1B1(3), ATP5A1(7), ATP5B(3), ATP5C1(1), ATP5F1(4), ATP5G1(2), ATP5G2(1), ATP5I(1), ATP5J(3), CANT1(1), DCK(4), ENPP1(8), ENPP3(14), ENTPD1(2), FHIT(2), GART(6), GDA(3), GMPS(11), GUCY1A2(9), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(6), GUCY2F(21), GUK1(6), HPRT1(2), IMPDH1(5), IMPDH2(3), NPR1(10), NPR2(10), NT5C(1), NT5E(5), NT5M(3), NUDT2(2), PAICS(3), PAPSS1(5), PAPSS2(5), PDE1A(10), PDE4A(9), PDE4B(12), PDE4C(2), PDE4D(7), PDE5A(11), PDE6B(5), PDE6C(10), PDE7B(5), PDE8A(5), PDE9A(8), PFAS(8), PKLR(5), PKM2(4), POLB(3), POLD1(11), POLD2(5), POLG(5), POLL(6), POLQ(18), POLR1B(10), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), PPAT(7), PRPS1(3), PRPS1L1(2), PRPS2(6), PRUNE(3), RRM1(2), RRM2(5)	44584696	564	100	555	172	144	236	75	33	76	0	0.010	0.19
33	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	48	ACTA1(3), AGT(7), AKT1(3), CALM2(3), CALR(1), CAMK1(2), CAMK1G(3), CAMK4(3), CREBBP(24), CSNK1A1(4), EDN1(2), ELSPBP1(4), F2(8), GATA4(1), GSK3B(8), HAND1(5), IGF1(2), LIF(2), MAP2K1(2), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(7), MEF2C(8), MYH2(31), NFATC2(9), NFATC3(9), NFATC4(7), NPPA(1), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RAF1(5), RPS6KB1(2), SYT1(4)	16210768	211	67	205	57	51	81	31	12	36	0	0.011	0.19
34	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	75	AIFM1(9), AKT1(3), AKT2(4), AKT3(7), APAF1(11), ATM(42), BAD(2), BAX(3), BCL2L1(3), BID(2), BIRC2(10), BIRC3(2), CAPN1(2), CAPN2(5), CASP10(8), CASP3(3), CASP6(3), CASP7(4), CASP9(2), CFLAR(5), CHUK(7), CSF2RB(9), CYCS(2), DFFB(3), FAS(6), FASLG(5), IKBKB(8), IL1B(2), IL1R1(4), IL1RAP(5), IL3RA(8), IRAK1(4), IRAK2(5), IRAK3(7), IRAK4(5), MAP3K14(4), MYD88(1), NFKB1(7), NFKB2(9), NFKBIA(2), NTRK1(11), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKACA(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RELA(4), RIPK1(8), TNFRSF10A(2), TNFRSF10B(4), TNFRSF10C(2), TNFRSF10D(5), TNFRSF1A(4), TRAF2(2)	26911968	371	81	362	108	84	144	49	22	68	4	0.011	0.19
35	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	15	AKT1(3), EIF2B5(4), EIF2S2(5), EIF2S3(5), EIF4E(2), GSK3B(8), IGF1(2), IGF1R(10), PDK2(3), PDPK1(2), PPP2CA(4), RPS6(6), RPS6KB1(2)	4693400	56	35	55	20	14	21	6	3	12	0	0.011	0.19
36	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(7), CREBBP(24), DUSP1(2), EP300(23), IKBKB(8), IL1B(2), IL8(3), MAP2K3(7), MAP2K6(6), MAP3K14(4), MAP3K7(8), MAPK14(4), MYD88(1), NFKB1(7), NFKBIA(2), NR3C1(11), RELA(4), TGFBR1(3), TGFBR2(6), TLR2(11)	10374088	143	52	140	45	28	54	26	9	26	0	0.011	0.19
37	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(7), AGTR1(1), ATF2(6), CALM2(3), EGFR(10), ELK1(2), GRB2(3), JUN(1), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK1(2), MAPK3(3), MAPK8(7), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), PAK1(1), PRKCA(7), PTK2(8), PTK2B(13), RAC1(1), RAF1(5), SHC1(5), SOS1(10), SRC(2), SYT1(4)	11993776	148	58	144	45	36	55	18	13	24	2	0.012	0.19
38	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	39	AKT1(3), AKT2(4), AKT3(7), BRAF(9), CAB39(6), DDIT4(2), EIF4B(5), FIGF(5), HIF1A(12), IGF1(2), MAPK1(2), MAPK3(3), PDPK1(2), PGF(1), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PRKAA1(5), PRKAA2(7), RHEB(2), RICTOR(20), RPS6(6), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA6(12), RPS6KB1(2), RPS6KB2(4), TSC1(9), TSC2(13), ULK2(7), ULK3(5), VEGFB(2), VEGFC(6)	15604656	252	71	245	65	70	90	35	17	40	0	0.012	0.19
39	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	9	ADAM17(8), APC(36), AXIN1(7), BTRC(11), DLL1(6), FZD1(3), GSK3B(8), PSEN1(5), WNT1(1)	5060688	85	38	84	21	20	36	7	5	13	4	0.013	0.19
40	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	31	AKT1(3), BAD(2), BCL2L1(3), CBL(8), CFLAR(5), CRKL(4), E2F1(6), FOS(2), GRB2(3), IL2RA(2), IL2RB(1), IL2RG(11), IRS1(10), JAK1(16), JAK3(5), MAPK1(2), MAPK3(3), MYC(6), NMI(1), PPIA(1), RAF1(5), RPS6KB1(2), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3), SYK(3)	11522824	124	55	122	37	30	59	17	7	11	0	0.013	0.19
41	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	145	AKT1(3), AKT2(4), AKT3(7), BCL2L1(3), CBL(8), CBLB(11), CBLC(4), CCND2(7), CCND3(3), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(24), CSF2RA(7), CSF2RB(9), CSF3(1), CSF3R(7), EP300(23), EPO(1), EPOR(3), GH1(2), GH2(2), GHR(8), GRB2(3), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(6), IFNAR2(6), IFNB1(2), IFNG(5), IFNGR1(5), IFNGR2(3), IFNK(2), IFNW1(1), IL10(2), IL10RA(3), IL10RB(6), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL13RA1(10), IL13RA2(3), IL15(1), IL19(1), IL2(2), IL20(5), IL20RA(1), IL21(2), IL21R(6), IL22RA1(2), IL22RA2(1), IL23A(4), IL23R(4), IL24(5), IL26(3), IL28A(2), IL28B(1), IL28RA(7), IL29(2), IL2RA(2), IL2RB(1), IL2RG(11), IL3RA(8), IL4R(5), IL5(1), IL5RA(7), IL6(4), IL6R(7), IL6ST(6), IL7(1), IL7R(7), IL9R(1), IRF9(4), JAK1(16), JAK2(14), JAK3(5), LEP(1), LEPR(10), LIF(2), LIFR(19), MPL(4), MYC(6), OSM(1), OSMR(11), PIAS1(3), PIAS2(12), PIAS3(7), PIAS4(4), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PIM1(3), PRL(4), PRLR(3), PTPN11(5), SOCS2(6), SOCS4(3), SOCS5(9), SOCS7(4), SOS1(10), SOS2(16), SPRED1(2), SPRED2(6), SPRY1(3), SPRY2(4), SPRY4(1), STAM(7), STAM2(4), STAT1(12), STAT2(5), STAT3(8), STAT4(6), STAT5A(2), STAT5B(3), STAT6(5), TPO(11), TSLP(1), TYK2(4)	50353176	687	113	672	215	182	255	104	45	93	8	0.014	0.19
42	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	36	ANAPC1(18), ANAPC10(1), ANAPC2(5), ANAPC4(5), ANAPC5(7), ANAPC7(3), BTRC(11), CDC16(1), CDC20(4), CDC23(3), CDC27(13), CUL1(12), CUL2(8), CUL3(13), FBXW11(4), ITCH(7), RBX1(1), SKP2(4), SMURF1(9), SMURF2(5), TCEB1(2), UBA1(14), UBE2C(1), UBE2D2(2), UBE2D3(2), UBE2E1(2), UBE2E2(2), VHL(2), WWP1(12), WWP2(4)	13713160	177	60	174	44	38	75	25	17	22	0	0.014	0.19
43	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(2), CHUK(7), ELK1(2), FOS(2), IKBKB(8), IRAK1(4), JUN(1), LY96(3), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K14(4), MAP3K7(8), MAPK14(4), MAPK8(7), MYD88(1), NFKB1(7), NFKBIA(2), RELA(4), TIRAP(2), TLR10(18), TLR2(11), TLR3(5), TLR4(13), TLR6(9), TLR7(12), TLR9(5), TRAF6(3)	12986768	185	59	183	42	44	63	31	16	27	4	0.014	0.19
44	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(24), EP300(23), LPL(9), NCOA1(15), NCOA2(13), PPARG(5), RXRA(1)	6593576	90	44	88	23	18	32	15	7	18	0	0.014	0.19
45	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	121	ALCAM(5), CADM1(2), CADM3(5), CD2(4), CD22(11), CD226(5), CD274(1), CD276(2), CD28(3), CD34(1), CD4(6), CD40(2), CD40LG(5), CD58(1), CD6(5), CD80(5), CD86(4), CD8A(2), CD8B(1), CD99(1), CDH1(12), CDH2(11), CDH3(5), CDH5(3), CLDN1(2), CLDN10(7), CLDN11(1), CLDN15(4), CLDN16(4), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CNTN1(12), CNTN2(6), CNTNAP1(9), CNTNAP2(24), CTLA4(2), F11R(1), GLG1(4), HLA-A(1), HLA-B(4), HLA-C(1), HLA-DMA(3), HLA-DOA(2), HLA-DOB(2), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRB5(2), HLA-E(1), HLA-F(2), HLA-G(2), ICAM1(1), ICAM2(3), ICAM3(2), ICOS(2), ICOSLG(2), ITGA4(8), ITGA6(10), ITGA8(14), ITGA9(13), ITGAL(12), ITGAM(19), ITGAV(6), ITGB1(5), ITGB2(10), ITGB7(4), ITGB8(4), JAM2(7), JAM3(2), L1CAM(13), MAG(7), MPZ(1), MPZL1(2), NCAM1(7), NEGR1(3), NEO1(12), NLGN1(6), NLGN2(4), NLGN3(18), NRCAM(10), NRXN1(25), NRXN2(16), NRXN3(21), OCLN(2), PTPRC(11), PTPRF(19), PTPRM(14), PVR(2), PVRL1(6), PVRL2(3), PVRL3(5), SDC1(1), SDC2(1), SDC3(1), SDC4(3), SELE(5), SELL(3), SELP(10), SELPLG(7), SIGLEC1(10), SPN(1), VCAM1(9), VCAN(45)	49775336	651	109	631	212	173	271	91	33	79	4	0.015	0.19
46	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	22	CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), JAK1(16), JUN(1), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK3(3), MAPK8(7), PDGFRA(19), PLCG1(8), PRKCA(7), RAF1(5), SHC1(5), SOS1(10), SRF(2), STAT1(12), STAT3(8), STAT5A(2)	10435592	149	55	142	34	38	51	21	15	20	4	0.015	0.19
47	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(2), C1GALT1(2), C1GALT1C1(4), GALNT1(8), GALNT10(4), GALNT11(12), GALNT12(2), GALNT13(14), GALNT14(4), GALNT2(5), GALNT3(6), GALNT4(7), GALNT5(5), GALNT6(1), GALNT7(9), GALNT8(9), GALNTL1(7), GALNTL2(11), GALNTL4(4), GALNTL5(9), GCNT1(3), GCNT3(3), OGT(13), ST3GAL1(1), ST3GAL2(3), ST6GALNAC1(2), WBSCR17(11)	11595240	161	58	154	60	37	59	27	12	26	0	0.015	0.19
48	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	27	ADRA1A(8), ADRA1B(5), ADRB1(1), ADRB2(5), CHRM1(3), CHRM2(8), CHRM3(6), CHRM4(6), CHRM5(8), DRD1(5), DRD2(6), DRD3(4), DRD5(8), HRH1(9), HRH2(3), HTR1A(11), HTR1B(4), HTR1D(5), HTR1E(5), HTR1F(10), HTR2A(9), HTR2B(2), HTR2C(13), HTR4(5), HTR5A(7), HTR6(3), HTR7(3)	8312960	162	51	155	51	56	64	25	8	9	0	0.015	0.19
49	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	39	CALM2(3), CD3D(3), CD3E(1), CD3G(1), ELK1(2), FOS(2), FYN(6), GRB2(3), JUN(1), LCK(3), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK3(3), MAPK8(7), NFATC2(9), NFATC3(9), NFATC4(7), NFKB1(7), NFKBIA(2), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKCA(7), PTPN7(4), RAC1(1), RAF1(5), RELA(4), SHC1(5), SOS1(10), SYT1(4), VAV1(10), ZAP70(6)	14912240	174	64	169	46	50	57	23	13	29	2	0.016	0.20
50	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	23	AKT1(3), AKT2(4), AKT3(7), BAD(2), GRB2(3), GSK3A(8), GSK3B(8), IL4R(5), IRS1(10), JAK1(16), JAK3(5), MAP4K1(9), MAPK1(2), MAPK3(3), PDK1(2), PIK3CD(9), PPP1R13B(5), RAF1(5), SHC1(5), SOS1(10), SOS2(16), STAT6(5)	11280528	142	58	136	39	32	60	26	7	15	2	0.017	0.21
51	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	27	CD4(6), CSF1(3), CSF3(1), IFNB1(2), IFNG(5), IL10(2), IL12A(5), IL12B(2), IL15(1), IL2(2), IL5(1), IL6(4), IL7(1), IL8(3), LTA(2), TGFB1(2), TGFB2(5), TGFB3(8)	4784416	55	36	54	20	13	28	8	1	5	0	0.017	0.21
52	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	121	ACTB(3), ACTG1(1), ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), AKT1(3), AKT2(4), AKT3(7), AMOTL1(10), ASH1L(32), CASK(13), CDC42(4), CDK4(3), CGN(9), CLDN1(2), CLDN10(7), CLDN11(1), CLDN15(4), CLDN16(4), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CSDA(2), CSNK2A1(7), CSNK2A2(3), CTNNA1(15), CTNNA2(9), CTNNA3(8), CTTN(4), EPB41(9), EPB41L1(10), EPB41L2(11), EPB41L3(16), EXOC3(6), EXOC4(1), F11R(1), GNAI1(4), GNAI2(4), GNAI3(3), HCLS1(8), IGSF5(6), INADL(13), JAM2(7), JAM3(2), LLGL1(9), LLGL2(4), MAGI1(20), MAGI2(23), MAGI3(12), MLLT4(17), MPDZ(16), MPP5(5), MRAS(1), MYH1(34), MYH10(23), MYH11(25), MYH13(17), MYH14(17), MYH15(19), MYH2(31), MYH3(20), MYH4(21), MYH6(12), MYH7(26), MYH7B(10), MYH8(25), MYH9(18), MYL2(1), MYL5(1), MYL7(3), MYL9(3), MYLPF(2), OCLN(2), PARD3(19), PARD6B(2), PPM1J(2), PPP2CA(4), PPP2CB(2), PPP2R1B(5), PPP2R2A(10), PPP2R2B(7), PPP2R2C(2), PPP2R3A(10), PPP2R4(4), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCI(6), PRKCQ(6), PRKCZ(3), RAB13(2), RAB3B(1), RHOA(3), RRAS(1), RRAS2(4), SPTAN1(23), SRC(2), SYMPK(15), TJAP1(5), TJP1(18), TJP2(13), TJP3(5), VAPA(5), YES1(6), ZAK(11)	67192624	949	125	924	313	250	366	140	50	133	10	0.019	0.22
53	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(4), CREB1(5), CREBBP(24), EP300(23), NCOA3(8), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RARA(1), RXRA(1)	7226968	87	44	84	27	18	34	10	6	19	0	0.019	0.22
54	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(5), CYP2A13(6), CYP2A6(10), CYP2A7(4), NAT1(7), NAT2(3), XDH(9)	2971784	44	30	41	15	17	19	4	1	3	0	0.019	0.22
55	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	30	AKT1(3), APC(36), AR(4), ASAH1(6), BRAF(9), CCL13(2), CCL15(1), CCL16(1), DAG1(4), EGFR(10), GNA11(2), GNA15(1), GNAI1(4), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), KCNJ3(9), KCNJ5(5), KCNJ9(4), MAPK1(2), MAPK10(7), MAPK14(4), PHKA2(12), PIK3CD(9), PTX3(1), RAF1(5), SRC(2)	17511528	213	68	212	80	53	82	33	6	31	8	0.020	0.22
56	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	73	ACP1(3), ACTB(3), ACTG1(1), ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), ACVR1B(5), ACVR1C(3), CDC42(4), CDH1(12), CREBBP(24), CSNK2A1(7), CSNK2A2(3), CTNNA1(15), CTNNA2(9), CTNNA3(8), CTNND1(17), EGFR(10), EP300(23), ERBB2(3), FARP2(13), FER(10), FGFR1(7), FYN(6), IGF1R(10), INSR(12), IQGAP1(9), LEF1(8), LMO7(17), MAP3K7(8), MAPK1(2), MAPK3(3), MET(9), MLLT4(17), NLK(5), PARD3(19), PTPN1(4), PTPRB(19), PTPRF(19), PTPRJ(10), PTPRM(14), PVRL1(6), PVRL2(3), PVRL3(5), PVRL4(4), RAC1(1), RAC2(2), RHOA(3), SMAD2(7), SMAD3(5), SMAD4(3), SNAI1(2), SNAI2(5), SORBS1(14), SRC(2), SSX2IP(8), TCF7(3), TCF7L1(2), TCF7L2(10), TGFBR1(3), TGFBR2(6), TJP1(18), VCL(8), WAS(8), WASF1(3), WASF2(3), WASF3(7), WASL(7), YES1(6)	42439248	551	101	535	161	141	208	77	33	92	0	0.021	0.23
57	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	AKT1(3), AKT2(4), AKT3(7), ARHGEF11(18), CDC42(4), DLG4(10), GNA13(7), LPA(11), MAP2K4(4), MAP3K1(24), MAP3K5(19), MAPK8(7), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PDK1(2), PHKA2(12), PI3(2), PIK3CB(13), PLD1(9), PLD2(7), PLD3(2), PTK2(8), RDX(11), ROCK1(15), ROCK2(10), SERPINA4(4), SRF(2)	17428200	240	66	232	66	53	97	28	15	41	6	0.021	0.23
58	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	100	ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), ARHGAP5(18), CD99(1), CDC42(4), CDH5(3), CLDN1(2), CLDN10(7), CLDN11(1), CLDN15(4), CLDN16(4), CLDN17(2), CLDN18(4), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CTNNA1(15), CTNNA2(9), CTNNA3(8), CTNND1(17), CXCL12(2), CXCR4(1), CYBB(8), EZR(4), F11R(1), GNAI1(4), GNAI2(4), GNAI3(3), ICAM1(1), ITGA4(8), ITGAL(12), ITGAM(19), ITGB1(5), ITGB2(10), ITK(5), JAM2(7), JAM3(2), MAPK13(2), MAPK14(4), MLLT4(17), MMP2(6), MMP9(11), MSN(12), MYL2(1), MYL5(1), MYL7(3), MYL9(3), MYLPF(2), NCF1(3), NCF2(4), NCF4(5), NOX1(10), NOX3(2), OCLN(2), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG1(8), PLCG2(23), PRKCA(7), PRKCG(6), PTK2(8), PTK2B(13), PTPN11(5), PXN(4), RAC1(1), RAC2(2), RAP1A(3), RAP1B(2), RAPGEF3(7), RAPGEF4(9), RASSF5(2), RHOA(3), RHOH(1), ROCK1(15), ROCK2(10), SIPA1(1), THY1(1), TXK(6), VASP(1), VAV1(10), VAV2(3), VAV3(9), VCAM1(9), VCL(8)	41339120	562	103	554	210	163	210	76	33	74	6	0.021	0.23
59	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	20	AARS(6), ABAT(9), ADSL(5), ADSS(6), AGXT(3), AGXT2(8), ASL(2), ASNS(5), ASPA(4), CAD(21), CRAT(2), DARS(4), DDO(6), GAD1(6), GAD2(10), GOT1(5), GOT2(3), GPT2(4), NARS(7), PC(9)	8972888	125	51	123	42	31	52	18	6	18	0	0.022	0.23
60	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	65	AKT1(3), AKT2(4), AKT3(7), BTK(4), FCER1A(7), FCER1G(1), FYN(6), GAB2(8), GRB2(3), IL5(1), INPP5D(9), LCP2(4), LYN(6), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK8(7), MAPK9(4), MS4A2(2), PDK1(2), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCG1(8), PLCG2(23), PRKCA(7), PRKCD(4), PRKCE(7), RAC1(1), RAC2(2), RAF1(5), SOS1(10), SOS2(16), SYK(3), VAV1(10), VAV2(3), VAV3(9)	22729200	311	81	304	101	83	120	45	20	39	4	0.023	0.23
61	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	92	ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CREB1(5), CREB3L1(3), CREB3L2(4), CREB3L3(7), CREB3L4(5), CREBBP(24), DCT(11), DVL2(5), DVL3(7), EDN1(2), EP300(23), FZD1(3), FZD10(6), FZD2(5), FZD3(5), FZD4(4), FZD6(11), FZD7(4), FZD9(5), GNAI1(4), GNAI2(4), GNAI3(3), GNAO1(4), GNAS(16), GSK3B(8), KIT(22), KITLG(2), LEF1(8), MAP2K1(2), MAPK1(2), MAPK3(3), MITF(3), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), POMC(1), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), RAF1(5), TCF7(3), TCF7L1(2), TCF7L2(10), TYR(8), TYRP1(7), WNT1(1), WNT10A(1), WNT10B(1), WNT11(3), WNT16(4), WNT2(2), WNT2B(7), WNT3(3), WNT4(1), WNT5A(4), WNT5B(3), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(3), WNT9A(1), WNT9B(1)	35370256	469	96	455	177	126	182	67	29	65	0	0.023	0.23
62	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	13	AKT1(3), AKT2(4), AKT3(7), CDKN1A(1), ELK1(2), GRB2(3), MAP2K1(2), NGFR(3), NTRK1(11), PIK3CD(9), SHC1(5), SOS1(10)	4623960	60	35	57	17	16	27	8	5	4	0	0.024	0.23
63	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	178	ACTB(3), ACTG1(1), ACTN1(7), ACTN2(7), ACTN3(6), ACTN4(6), AKT1(3), AKT2(4), AKT3(7), ARHGAP5(18), BAD(2), BIRC2(10), BIRC3(2), BRAF(9), CAPN2(5), CAV2(1), CCND2(7), CCND3(3), CDC42(4), CHAD(1), COL11A1(22), COL11A2(6), COL1A1(7), COL1A2(15), COL2A1(10), COL3A1(12), COL4A1(15), COL4A2(5), COL4A4(17), COL4A6(28), COL5A2(17), COL5A3(17), COL6A3(34), COL6A6(20), COMP(3), CRK(1), CRKL(4), DIAPH1(10), DOCK1(17), EGF(17), EGFR(10), ELK1(2), ERBB2(3), FARP2(13), FIGF(5), FLNA(27), FLNB(28), FLNC(27), FLT1(15), FN1(31), FYN(6), GRB2(3), GSK3B(8), HGF(13), IBSP(5), IGF1(2), IGF1R(10), ILK(4), ITGA1(13), ITGA10(7), ITGA11(6), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGAV(6), ITGB1(5), ITGB3(10), ITGB4(6), ITGB5(4), ITGB6(4), ITGB7(4), ITGB8(4), JUN(1), KDR(20), LAMA1(27), LAMA2(52), LAMA3(22), LAMA4(13), LAMB1(21), LAMB2(20), LAMB3(12), LAMB4(22), LAMC1(13), LAMC2(11), LAMC3(10), MAP2K1(2), MAPK1(2), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(4), MET(9), MYL2(1), MYL5(1), MYL7(3), MYL9(3), MYLK(10), MYLK2(6), MYLPF(2), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PARVA(3), PARVB(1), PARVG(2), PDGFB(2), PDGFC(2), PDGFD(6), PDGFRA(19), PDGFRB(10), PDPK1(2), PGF(1), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PIP5K1C(4), PPP1CA(3), PPP1CB(4), PPP1CC(2), PPP1R12A(8), PRKCA(7), PRKCG(6), PTK2(8), PXN(4), RAC1(1), RAC2(2), RAF1(5), RAP1A(3), RAP1B(2), RAPGEF1(9), RELN(36), RHOA(3), ROCK1(15), ROCK2(10), SHC1(5), SHC3(9), SHC4(5), SOS1(10), SOS2(16), SPP1(2), SRC(2), THBS1(9), THBS3(2), THBS4(6), TLN1(20), TLN2(20), TNC(14), TNN(11), TNR(11), TNXB(16), VASP(1), VAV1(10), VAV2(3), VAV3(9), VCL(8), VEGFB(2), VEGFC(6), VWF(19), ZYX(11)	124934960	1548	146	1518	513	392	626	211	82	203	34	0.024	0.23
64	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	100	ABL1(5), ANAPC1(18), ANAPC10(1), ANAPC2(5), ANAPC4(5), ANAPC5(7), ANAPC7(3), ATM(42), ATR(26), BUB1(7), BUB1B(4), BUB3(2), CCNA1(3), CCNA2(2), CCNB1(7), CCNB2(3), CCNB3(19), CCND2(7), CCND3(3), CCNE2(5), CCNH(3), CDC14A(4), CDC14B(5), CDC16(1), CDC20(4), CDC23(3), CDC25A(7), CDC25B(2), CDC25C(5), CDC27(13), CDC6(1), CDC7(10), CDK2(2), CDK4(3), CDK6(3), CDK7(4), CDKN1A(1), CDKN2A(1), CDKN2C(2), CDKN2D(1), CHEK1(2), CHEK2(11), CREBBP(24), CUL1(12), DBF4(11), E2F1(6), E2F2(2), E2F3(3), EP300(23), ESPL1(5), GSK3B(8), HDAC1(3), HDAC2(4), MAD1L1(11), MAD2L1(3), MAD2L2(2), MCM2(4), MCM3(8), MCM4(6), MCM5(7), MCM6(4), MCM7(3), MDM2(3), PCNA(2), PLK1(3), PRKDC(40), PTTG1(2), RBL1(13), RBL2(15), RBX1(1), SKP2(4), SMAD2(7), SMAD3(5), SMAD4(3), SMC1A(13), SMC1B(15), TGFB1(2), TGFB2(5), TGFB3(8), WEE1(1), YWHAE(2), YWHAG(3), YWHAH(2), YWHAQ(1), YWHAZ(1)	47794808	562	104	546	148	120	239	78	31	81	13	0.025	0.23
65	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	89	ACTB(3), BAD(2), CABIN1(11), CALM2(3), CAMK2B(1), CAMK4(3), CD3E(1), CD3G(1), CD69(1), CDKN1A(1), CNR1(6), CREBBP(24), CSNK2A1(7), CTLA4(2), EGR2(4), EGR3(5), EP300(23), FCER1A(7), FCGR3A(1), FKBP1B(1), FOS(2), FOSL1(3), GATA3(2), GATA4(1), GSK3A(8), GSK3B(8), ICOS(2), IFNB1(2), IFNG(5), IL10(2), IL1B(2), IL2(2), IL2RA(2), IL6(4), IL8(3), ITK(5), KPNA5(6), MAPK14(4), MAPK8(7), MAPK9(4), MEF2A(3), MEF2B(1), MEF2D(5), MYF5(4), NCK2(7), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NFKB2(9), NFKBIE(5), NPPB(2), NUP214(13), P2RX7(1), PAK1(1), PPIA(1), PPP3CB(5), PPP3CC(4), PTPRC(11), RELA(4), SLA(5), SP1(6), SP3(8), TGFB1(2), TRAF2(2), TRPV6(9), VAV1(10), VAV2(3), VAV3(9), XPO5(7)	31985056	353	85	344	121	88	142	51	18	54	0	0.025	0.23
66	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), IL6(4), IL6R(7), IL6ST(6), JAK1(16), JAK2(14), JAK3(5), JUN(1), MAP2K1(2), MAPK3(3), PTPN11(5), RAF1(5), SHC1(5), SOS1(10), SRF(2), STAT3(8)	8542856	107	47	104	26	23	39	18	9	14	4	0.025	0.23
67	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(3), AKT2(4), AKT3(7), BPNT1(1), GRB2(3), ILK(4), MAPK1(2), MAPK3(3), PDK1(2), PIK3CD(9), PTK2B(13), RBL2(15), SHC1(5), SOS1(10)	6115432	81	42	74	23	21	34	10	5	8	3	0.025	0.23
68	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(3), BCR(4), CRKL(4), FOS(2), GRB2(3), JAK2(14), JUN(1), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK3(3), MAPK8(7), MYC(6), RAF1(5), SOS1(10), STAT1(12), STAT5A(2), STAT5B(3)	8494248	109	49	105	24	29	37	15	9	13	6	0.026	0.23
69	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	23	BRCA1(14), CARM1(4), CREBBP(24), EP300(23), ERCC3(8), GRIP1(11), GTF2A1(3), GTF2E1(3), GTF2F1(5), HDAC1(3), HDAC2(4), HDAC3(8), HDAC4(12), HDAC5(10), HDAC6(12), MEF2C(8), NCOR2(16), NR0B1(6), NRIP1(14), PELP1(9), POLR2A(17), SRA1(1), TBP(3)	15221248	218	63	209	73	36	108	28	9	35	2	0.027	0.24
70	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CHUK(7), CREBBP(24), EP300(23), HDAC3(8), IKBKB(8), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), TNFRSF1A(4), TNFRSF1B(1), TRAF6(3)	7868544	99	42	95	29	14	43	16	3	23	0	0.027	0.24
71	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	32	AKT1(3), AKT2(4), AKT3(7), ASAH1(6), BRAF(9), DAG1(4), DRD2(6), EGFR(10), EPHB2(8), GRB2(3), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), KCNJ3(9), KCNJ5(5), KCNJ9(4), MAPK1(2), PI3(2), PIK3CB(13), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), RAF1(5), RGS20(1), SHC1(5), SOS1(10), SOS2(16), SRC(2), STAT3(8), TERF2IP(2)	20999152	250	72	242	96	59	102	40	12	33	4	0.028	0.24
72	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	132	ACTA1(3), ACTA2(5), ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ADM(2), ARRB1(4), ARRB2(3), ATF1(4), ATF2(6), ATF3(3), ATF4(3), ATF5(5), ATP2A2(6), ATP2A3(9), CACNB3(4), CALCA(1), CALM2(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CNN1(2), CORIN(8), CRHR1(2), DGKZ(8), ETS2(5), FOS(2), GABPA(3), GABPB2(8), GBA2(9), GJA1(5), GNB1(1), GNB2(6), GNB4(3), GNB5(1), GNG12(1), GNG2(2), GNG3(2), GRK4(9), GRK5(8), GRK6(2), GSTO1(3), GUCA2B(1), GUCY1A3(9), IGFBP1(4), IGFBP2(4), IGFBP3(3), IGFBP6(1), IL1B(2), IL6(4), ITPR1(23), ITPR2(25), ITPR3(15), JUN(1), MIB1(6), MYL2(1), MYLK2(6), NFKB1(7), NOS1(14), NOS3(6), OXTR(4), PDE4B(12), PDE4D(7), PLCB3(9), PLCD1(5), PLCG1(8), PLCG2(23), PRKACA(4), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(7), PRKCH(7), PRKCQ(6), PRKCZ(3), PRKD1(6), RAMP1(1), RAMP3(2), RGS1(4), RGS10(2), RGS14(4), RGS16(3), RGS17(3), RGS18(2), RGS2(2), RGS20(1), RGS3(8), RGS4(6), RGS5(4), RGS6(6), RGS7(6), RGS9(10), RYR1(59), RYR3(65), SLC8A1(9), SP1(6), TNXB(16), USP5(11), YWHAH(2), YWHAQ(1)	58749464	748	110	726	279	220	314	99	31	80	4	0.028	0.24
73	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	17	CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), INSR(12), IRS1(10), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(7), PTPN11(5), RAF1(5), SHC1(5), SLC2A4(5), SOS1(10), SRF(2)	6946728	81	43	78	22	23	37	10	5	6	0	0.029	0.24
74	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	138	ADA(2), ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ADK(1), ADSL(5), ADSS(6), ADSSL1(5), AK2(2), AK5(5), AK7(10), ALLC(7), AMPD1(17), AMPD2(6), AMPD3(4), ATIC(6), CANT1(1), DCK(4), ENPP1(8), ENPP3(14), ENTPD1(2), ENTPD3(4), ENTPD5(2), ENTPD6(8), FHIT(2), GART(6), GDA(3), GMPR(6), GMPR2(2), GMPS(11), GUCY1A2(9), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(6), GUCY2F(21), GUK1(6), HPRT1(2), IMPDH1(5), IMPDH2(3), NME7(2), NPR1(10), NPR2(10), NT5C(1), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(8), NT5E(5), NT5M(3), NUDT2(2), NUDT5(1), PAICS(3), PAPSS1(5), PAPSS2(5), PDE10A(11), PDE11A(10), PDE1A(10), PDE1C(10), PDE2A(11), PDE3B(9), PDE4A(9), PDE4B(12), PDE4C(2), PDE4D(7), PDE5A(11), PDE6D(1), PDE7B(5), PDE8A(5), PDE8B(15), PDE9A(8), PFAS(8), PKLR(5), PKM2(4), PNPT1(5), POLA1(23), POLA2(1), POLD1(11), POLD2(5), POLD3(4), POLD4(1), POLE2(2), POLE3(2), POLE4(1), POLR1A(11), POLR1B(10), POLR1C(2), POLR1D(1), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), POLR3A(5), POLR3B(6), POLR3G(2), POLR3GL(3), POLR3H(3), PPAT(7), PRIM1(2), PRIM2(7), PRPS1(3), PRPS1L1(2), PRPS2(6), PRUNE(3), RFC5(7), RRM1(2), RRM2(5), RRM2B(4), XDH(9)	57999016	736	108	718	224	189	292	105	45	105	0	0.030	0.24
75	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(4), CALM2(3), ELK1(2), FCER1A(7), FCER1G(1), FOS(2), GRB2(3), JUN(1), LYN(6), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK1(2), MAPK3(3), MAPK8(7), NFATC2(9), NFATC3(9), NFATC4(7), PAK2(3), PLA2G4A(9), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), RAF1(5), SHC1(5), SOS1(10), SYK(3), SYT1(4), VAV1(10)	13666784	164	61	159	44	57	47	21	12	25	2	0.030	0.24
76	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(17), EGFR(10), ERBB3(14), NRG1(20)	3732648	61	32	59	13	13	26	11	4	7	0	0.031	0.24
77	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(4), CD4(6), IL1B(2), IL5(1), IL5RA(7), IL6(4)	1997640	24	19	22	7	2	12	2	0	8	0	0.031	0.24
78	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	20	ABL1(5), ATM(42), ATR(26), CCNA1(3), CDC25A(7), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN2A(1), DHFR(3), E2F1(6), GSK3B(8), HDAC1(3), SKP2(4), TGFB1(2), TGFB2(5), TGFB3(8)	9624880	132	46	129	40	20	56	20	6	24	6	0.031	0.24
79	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(4)	5211968	73	36	71	18	15	36	3	3	16	0	0.032	0.24
80	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(4)	5211968	73	36	71	18	15	36	3	3	16	0	0.032	0.24
81	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), SHMT1(4)	5211968	73	36	71	18	15	36	3	3	16	0	0.032	0.24
82	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(12), AKT1(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CREB1(5), GNAS(16), GRB2(3), MAPK1(2), MAPK14(4), MAPK3(3), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), RAC1(1), RPS6KA1(1), RPS6KA5(7), SOS1(10)	8547320	109	47	104	34	23	47	13	9	17	0	0.034	0.25
83	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	77	ABL1(5), ABL2(17), AKT1(3), AKT2(4), AKT3(7), ARAF(8), BAD(2), BRAF(9), BTC(1), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CBL(8), CBLB(11), CBLC(4), CDKN1A(1), CRK(1), CRKL(4), EGF(17), EGFR(10), ELK1(2), ERBB2(3), ERBB3(14), ERBB4(19), EREG(3), GAB1(5), GRB2(3), GSK3B(8), HBEGF(2), JUN(1), MAP2K1(2), MAP2K4(4), MAPK1(2), MAPK10(7), MAPK3(3), MAPK8(7), MAPK9(4), MYC(6), NCK1(4), NCK2(7), NRG1(20), NRG2(2), NRG3(11), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG1(8), PLCG2(23), PRKCA(7), PRKCG(6), PTK2(8), RAF1(5), RPS6KB1(2), RPS6KB2(4), SHC1(5), SHC3(9), SHC4(5), SOS1(10), SOS2(16), SRC(2), STAT5A(2), STAT5B(3)	33685096	464	91	455	133	125	177	70	28	58	6	0.034	0.25
84	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(6), BCR(4), BLNK(3), ELK1(2), FOS(2), GRB2(3), JUN(1), LYN(6), MAP2K1(2), MAP3K1(24), MAPK1(2), MAPK3(3), PAPPA(26), RAC1(1), RPS6KA1(1), RPS6KA3(15), SHC1(5), SOS1(10), SYK(3), VAV1(10), VAV2(3), VAV3(9)	10307624	141	53	137	42	44	43	22	11	19	2	0.036	0.26
85	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	81	ACVR1(9), ACVR1B(5), ACVR1C(3), ACVR2A(5), ACVR2B(5), ACVRL1(1), AMHR2(2), BMP2(5), BMP4(7), BMP5(12), BMP6(4), BMP7(10), BMP8A(3), BMP8B(1), BMPR1A(4), BMPR1B(6), BMPR2(9), CHRD(8), COMP(3), CREBBP(24), CUL1(12), DCN(7), E2F4(2), EP300(23), FST(4), GDF5(7), GDF6(3), ID1(2), ID2(1), IFNG(5), INHBA(3), INHBB(2), INHBC(1), INHBE(4), LEFTY1(3), LEFTY2(1), LTBP1(15), MAPK1(2), MAPK3(3), MYC(6), NODAL(2), NOG(2), PPP2CA(4), PPP2CB(2), PPP2R1B(5), PPP2R2A(10), PPP2R2B(7), PPP2R2C(2), RBL1(13), RBL2(15), RBX1(1), RHOA(3), ROCK1(15), ROCK2(10), RPS6KB1(2), RPS6KB2(4), SMAD1(1), SMAD2(7), SMAD3(5), SMAD4(3), SMAD5(8), SMAD7(2), SMAD9(1), SMURF1(9), SMURF2(5), SP1(6), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), THBS1(9), THBS3(2), THBS4(6), ZFYVE16(18), ZFYVE9(15)	33399400	450	92	436	125	130	168	61	21	63	7	0.036	0.26
86	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(4), GABARAP(1), GABRA1(8), GABRA2(10), GABRA3(12), GABRA4(12), GABRA5(6), GABRA6(6), GPHN(11), NSF(2), SRC(2), UBQLN1(4)	4361824	78	35	72	26	21	32	11	4	10	0	0.037	0.26
87	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(3), IL2RG(11), IL4R(5), IRS1(10), JAK1(16), JAK3(5), RPS6KB1(2), SHC1(5), STAT6(5)	5423264	65	38	65	23	14	29	10	3	9	0	0.037	0.26
88	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(32), ASH2L(9), C17orf79(2), CARM1(4), CTCFL(11), DOT1L(5), EED(6), EHMT2(1), EZH1(8), EZH2(9), FBXO11(5), HCFC1(21), HSF4(2), JMJD4(2), JMJD6(4), KDM6A(10), MEN1(5), MLL(25), MLL2(38), MLL3(44), MLL5(20), NSD1(25), OGT(13), PPP1CA(3), PPP1CB(4), PPP1CC(2), PRDM2(14), PRDM9(23), PRMT1(2), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), RBBP5(7), SATB1(14), SETD1A(9), SETD2(26), SETD7(5), SETD8(3), SETDB1(14), SETDB2(11), SETMAR(5), SMYD3(4), STK38(7), SUV39H1(7), SUV39H2(2), SUV420H1(11), SUZ12(5), WHSC1(15), WHSC1L1(16)	41155104	530	96	518	137	121	209	80	23	89	8	0.037	0.26
89	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(8), GALNT10(4), GALNT2(5), GALNT3(6), GALNT4(7), GALNT6(1), GALNT7(9), GALNT8(9), GCNT1(3), ST3GAL1(1), ST3GAL2(3), ST3GAL4(3), WBSCR17(11)	5177496	70	38	68	24	15	26	16	7	6	0	0.037	0.26
90	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(7), EGF(17), EGFR(10), ELK1(2), FOS(2), GRB2(3), JAK1(16), JUN(1), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK3(3), MAPK8(7), PLCG1(8), PRKCA(7), RAF1(5), SHC1(5), SOS1(10), SRF(2), STAT1(12), STAT3(8), STAT5A(2)	11493064	157	55	150	41	39	56	23	14	23	2	0.039	0.26
91	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	15	AKT1(3), ATM(42), BAX(3), CDKN1A(1), CPB2(6), CSNK1A1(4), FHL2(1), HIF1A(12), IGFBP3(3), MAPK8(7), MDM2(3), NQO1(3)	6006312	88	37	86	29	21	20	20	4	19	4	0.040	0.26
92	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	29	ABP1(5), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), ALDH3A1(2), ALDH3B2(5), AOC2(6), AOC3(9), AOX1(14), DBH(7), DCT(11), DDC(9), FAH(5), GOT1(5), GOT2(3), GSTZ1(4), HPD(7), MAOA(10), MAOB(5), PNMT(1), TAT(5), TPO(11), TYR(8)	10752536	164	50	156	44	42	58	26	13	25	0	0.040	0.26
93	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	13	APAF1(11), ATM(42), BAX(3), CDK2(2), CDK4(3), CDKN1A(1), E2F1(6), MDM2(3), PCNA(2), TIMP3(8)	5394744	81	35	78	21	18	23	16	3	17	4	0.040	0.26
94	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(11), GBA3(7), LPO(4), MPO(6), PRDX2(4), PRDX5(1), PRDX6(2), TPO(11), TYR(8)	3365608	54	29	54	22	17	22	8	1	6	0	0.040	0.26
95	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	6	CREBBP(24), EP300(23), MAPK1(2), MAPK3(3), PELP1(9), SRC(2)	4760112	63	34	61	17	12	25	9	3	14	0	0.041	0.26
96	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(9), GLS2(6), GLUD1(3), GLUD2(6)	1506104	24	17	23	8	3	9	4	1	7	0	0.041	0.26
97	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(42), ATR(26), CDC25C(5), CHEK1(2), CHEK2(11), YWHAH(2)	5642496	88	36	85	15	16	28	15	6	19	4	0.041	0.26
98	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(18), C5(14), C6(13), C7(16), ICAM1(1), IL6(4), IL8(3), ITGA4(8), ITGAL(12), ITGB1(5), ITGB2(10), SELP(10), SELPLG(7), VCAM1(9)	8782672	130	47	125	34	29	59	14	6	18	4	0.044	0.28
99	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(5), CDO1(4), CSAD(7), GAD1(6), GAD2(10), GGT1(5)	2106264	37	23	37	9	10	9	13	0	5	0	0.045	0.28
100	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	46	ACTG1(1), APAF1(11), ARHGDIB(1), BAG4(3), BID(2), BIRC2(10), BIRC3(2), CASP2(4), CASP3(3), CASP6(3), CASP7(4), CASP9(2), CFLAR(5), CHUK(7), CRADD(2), CYCS(2), DAXX(6), DFFB(3), GSN(4), LMNA(5), LMNB1(4), MAP3K1(24), MAP3K14(4), MAP3K5(19), MAPK8(7), MDM2(3), NFKB1(7), NFKBIA(2), NUMA1(17), PAK2(3), PRKCD(4), PRKDC(40), PSEN1(5), PSEN2(3), PTK2(8), RELA(4), RIPK1(8), SPTAN1(23), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(2)	22933552	277	70	271	81	72	104	37	18	44	2	0.049	0.30
101	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	54	ATP12A(13), ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), ATP7B(9), COX10(1), COX4I1(2), COX5A(1), COX5B(1), COX6A1(3), COX6B1(1), COX6C(2), COX7A1(2), COX7B(3), COX7C(2), COX8A(1), NDUFA1(1), NDUFA10(6), NDUFA4(1), NDUFA5(4), NDUFA8(5), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(2), PPA2(3), SDHA(10), SDHB(1), SHMT1(4), UQCRB(3), UQCRC1(2)	12205072	168	59	164	42	47	74	15	7	25	0	0.049	0.30
102	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(7), GAD1(6), HDC(6), PNMT(1), TPH1(9)	1926216	29	22	28	8	8	7	7	1	4	2	0.050	0.30
103	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	12	AKT1(3), CREB1(5), MAP2K1(2), MAP2K3(7), MAP2K6(6), MAP3K1(24), MAPK1(2), MAPK14(4), MAPK3(3), NFKB1(7), RELA(4), SP1(6)	4947600	73	34	72	14	10	29	14	9	9	2	0.051	0.30
104	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(5), IFNGR1(5), IFNGR2(3), JAK1(16), JAK2(14), STAT1(12)	3048168	55	27	54	17	11	17	9	3	11	4	0.052	0.30
105	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(5), GRB2(3), HBXIP(1), PTK2B(13), SHC1(5), SOS1(10), SRC(2)	3088344	39	27	37	11	10	20	4	3	2	0	0.052	0.30
106	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	21	ATP5E(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1D(2), ATP6V1E1(3), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), FDXR(2), SHMT1(4)	5509072	75	36	73	18	15	36	5	3	16	0	0.052	0.30
107	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(3), BAD(2), GRB2(3), IGF1R(10), IRS1(10), MAP2K1(2), MAPK1(2), MAPK3(3), RAF1(5), SHC1(5), SOS1(10), YWHAH(2)	5462200	57	36	55	20	11	27	11	4	4	0	0.053	0.30
108	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(23), POLA2(1), POLB(3), POLD1(11), POLD2(5), POLD3(4), POLD4(1), POLE2(2), POLE3(2), POLE4(1), POLG(5), POLG2(2), POLH(11), POLI(6), POLK(11), POLL(6), POLM(5), POLQ(18), PRIM1(2), PRIM2(7), REV1(9), REV3L(29), RFC5(7)	15226456	171	64	164	38	40	64	28	6	33	0	0.054	0.30
109	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(12), GNAS(16), GNB1(1), PRKACA(4), PRKAR1A(4)	2146440	37	24	35	6	11	17	3	2	4	0	0.055	0.30
110	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	CREBBP(24), EP300(23), FYN(6), IL2RG(11), IL7(1), IL7R(7), JAK1(16), JAK3(5), LCK(3), NMI(1), PTK2B(13), STAT5A(2), STAT5B(3)	8598904	115	46	113	40	27	48	14	5	21	0	0.055	0.30
111	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(1), AKT1(3), APC(36), ASAH1(6), DAG1(4), DLG4(10), EPHB2(8), GNAI1(4), ITPR1(23), ITPR2(25), ITPR3(15), KCNJ3(9), KCNJ5(5), KCNJ9(4), MAPK1(2), PTX3(1), RAC1(1), RHO(3), RYR1(59)	16678000	219	68	212	92	62	95	27	6	23	6	0.055	0.30
112	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	16	CSF1(3), CSF1R(6), DDX20(4), E2F1(6), E2F4(2), ETS1(4), ETS2(5), FOS(2), HDAC2(4), HDAC5(10), JUN(1), NCOR2(16), RBL1(13), RBL2(15), SIN3B(11)	7260448	102	43	97	26	25	43	9	9	13	3	0.055	0.30
113	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(4), GNAS(16), GNB1(1), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7)	3152328	49	29	46	17	11	23	4	4	7	0	0.056	0.31
114	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(5), IFNGR1(5), JAK1(16), JAK2(14), PTPRU(12), REG1A(2), STAT1(12)	4155240	67	32	66	19	12	25	9	3	14	4	0.057	0.31
115	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(3), CD3D(3), CD3E(1), CD3G(1), CD8A(2), ICAM1(1), ITGAL(12), ITGB2(10), PTPRC(11), THY1(1)	3785472	49	29	49	16	12	22	6	1	8	0	0.060	0.31
116	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	20	AKT1(3), APC(36), AXIN1(7), CD14(2), FZD1(3), GJA1(5), GNAI1(4), GSK3B(8), IRAK1(4), LBP(2), LEF1(8), LY96(3), MYD88(1), NFKB1(7), PDPK1(2), PPP2CA(4), RELA(4), TIRAP(2), TLR4(13), WNT1(1)	8148784	119	44	118	26	28	42	13	8	24	4	0.060	0.31
117	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	ADRB2(5), AKT1(3), ANXA1(4), CALM2(3), GNAS(16), GNB1(1), NFKB1(7), NOS3(6), NPPA(1), NR3C1(11), RELA(4), SYT1(4)	4701584	65	35	63	13	19	27	9	1	9	0	0.060	0.31
118	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(16), GABBR1(8), GPRC5A(4), GPRC5B(5), GPRC5C(2), GPRC5D(3), GRM1(18), GRM2(5), GRM3(14), GRM4(12), GRM5(19), GRM7(10), GRM8(17)	7453640	133	45	128	46	45	41	24	5	16	2	0.061	0.31
119	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCL4(1), CCR1(3), CCR2(4), CCR3(4), CCR4(2), CCR7(6), CD28(3), CD4(6), CXCR3(5), CXCR4(1), IFNG(5), IFNGR1(5), IFNGR2(3), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL18R1(5), IL2(2), IL4R(5), IL5(1), TGFB1(2), TGFB2(5), TGFB3(8)	7073952	102	43	101	31	17	52	10	7	16	0	0.061	0.31
120	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	32	AKT1(3), ATF1(4), CDC42(4), CREB1(5), CREB5(3), DUSP1(2), DUSP10(5), EEF2K(7), EIF4E(2), ELK1(2), IL1R1(4), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K10(6), MAP3K4(16), MAP3K5(19), MAP3K7(8), MAPK1(2), MAPK13(2), MAPK14(4), MAPKAPK2(4), MAPKAPK5(4), MKNK1(3), MKNK2(3), MYEF2(5), NFKB1(7), NR2C2(5), SRF(2), TRAF6(3)	11512904	151	53	149	47	38	68	23	9	13	0	0.061	0.31
121	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS(6), AARS2(5), ABAT(9), ACY3(3), ADSL(5), ADSS(6), ADSSL1(5), AGXT(3), AGXT2(8), ASL(2), ASNS(5), ASPA(4), ASS1(2), CAD(21), CRAT(2), DARS(4), DARS2(6), DDO(6), DLAT(1), DLD(3), GAD1(6), GAD2(10), GOT1(5), GOT2(3), GPT2(4), NARS(7), NARS2(6), PC(9), PDHA1(4), PDHA2(8), PDHB(3)	13105312	171	59	168	65	42	71	25	10	23	0	0.062	0.32
122	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3D(3), CD3E(1), CD3G(1), GZMB(2), HLA-A(1), ICAM1(1), ITGAL(12), ITGB2(10), PRF1(6)	2973768	39	27	38	15	8	21	5	0	5	0	0.064	0.33
123	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(6), CTH(4), GOT1(5), GOT2(3), LDHA(6), LDHB(2), LDHC(4)	2381792	30	24	29	14	9	10	3	5	3	0	0.066	0.33
124	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(10), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2)	4131184	53	30	53	16	9	22	6	6	10	0	0.067	0.33
125	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(3), APAF1(11), ATM(42), BAD(2), BAX(3), BCL2L1(3), BID(2), CASP3(3), CASP6(3), CASP7(4), CASP9(2), CYCS(2), PRKCA(7), PTK2(8), PXN(4), STAT1(12), TLN1(20)	9736232	131	46	128	34	35	39	25	6	22	4	0.069	0.34
126	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(7), AGTR2(7), CALM2(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CDK5(1), F2(8), FYN(6), GNA11(2), GNAI1(4), GNB1(1), GRB2(3), JAK2(14), MAP2K1(2), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(7), MAPT(9), MYLK(10), PLCG1(8), PRKCA(7), PTK2B(13), RAF1(5), SHC1(5), SOS1(10), STAT1(12), STAT3(8), STAT5A(2), SYT1(4)	14708880	181	62	175	58	49	72	26	9	21	4	0.069	0.34
127	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	242	ACVR1(9), ACVR1B(5), ACVR2A(5), ACVR2B(5), AMHR2(2), BMP2(5), BMP7(10), BMPR1A(4), BMPR1B(6), BMPR2(9), CCL1(1), CCL13(2), CCL14(1), CCL15(1), CCL16(1), CCL17(1), CCL18(1), CCL23(3), CCL24(2), CCL25(1), CCL28(1), CCL4(1), CCL5(2), CCL7(2), CCL8(1), CCR1(3), CCR2(4), CCR3(4), CCR4(2), CCR6(5), CCR7(6), CCR8(5), CCR9(1), CD27(1), CD40(2), CD40LG(5), CD70(2), CLCF1(1), CNTF(1), CNTFR(2), CSF1(3), CSF1R(6), CSF2RA(7), CSF2RB(9), CSF3(1), CSF3R(7), CX3CL1(3), CX3CR1(4), CXCL1(1), CXCL10(2), CXCL12(2), CXCL13(2), CXCL16(2), CXCL2(2), CXCL3(1), CXCL5(3), CXCL9(2), CXCR3(5), CXCR4(1), CXCR6(1), EDA(5), EDA2R(5), EGF(17), EGFR(10), EPO(1), EPOR(3), FAS(6), FASLG(5), FLT1(15), FLT3(7), FLT3LG(2), FLT4(9), GDF5(7), GH1(2), GH2(2), GHR(8), HGF(13), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(6), IFNAR2(6), IFNB1(2), IFNG(5), IFNGR1(5), IFNGR2(3), IFNK(2), IFNW1(1), IL10(2), IL10RA(3), IL10RB(6), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL13RA1(10), IL15(1), IL17RA(3), IL17RB(3), IL18(1), IL18R1(5), IL18RAP(11), IL19(1), IL1B(2), IL1R1(4), IL1R2(5), IL1RAP(5), IL2(2), IL20(5), IL20RA(1), IL21(2), IL21R(6), IL22RA1(2), IL22RA2(1), IL23A(4), IL23R(4), IL24(5), IL25(1), IL26(3), IL28A(2), IL28B(1), IL28RA(7), IL29(2), IL2RA(2), IL2RB(1), IL2RG(11), IL3RA(8), IL4R(5), IL5(1), IL5RA(7), IL6(4), IL6R(7), IL6ST(6), IL7(1), IL7R(7), IL8(3), IL9R(1), INHBA(3), INHBB(2), INHBC(1), INHBE(4), KDR(20), KIT(22), KITLG(2), LEP(1), LEPR(10), LIF(2), LIFR(19), LTA(2), LTBR(5), MET(9), MPL(4), NGFR(3), OSM(1), OSMR(11), PDGFB(2), PDGFC(2), PDGFRA(19), PDGFRB(10), PF4(1), PF4V1(1), PLEKHO2(3), PRL(4), PRLR(3), RELT(1), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), TNFRSF10A(2), TNFRSF10B(4), TNFRSF10C(2), TNFRSF10D(5), TNFRSF11A(4), TNFRSF11B(6), TNFRSF13B(1), TNFRSF14(2), TNFRSF19(3), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TNFRSF8(6), TNFRSF9(1), TNFSF11(5), TNFSF12(4), TNFSF13B(2), TNFSF14(2), TNFSF15(2), TNFSF18(3), TNFSF4(3), TNFSF8(1), TPO(11), TSLP(1), VEGFB(2), VEGFC(6), XCL2(1), XCR1(3)	62425320	846	119	830	260	230	326	127	47	112	4	0.070	0.34
128	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	AKR1B1(1), AKR1B10(3), B4GALT1(2), B4GALT2(3), G6PC(5), G6PC2(4), GAA(4), GALK1(1), GALK2(2), GALT(2), GANC(13), GCK(3), GLA(2), GLB1(4), HK1(9), HK2(5), HK3(8), HSD3B7(3), LALBA(1), LCT(24), MGAM(36), PFKM(4), PFKP(6), PGM1(5), PGM3(4), RDH11(1), RDH12(3), RDH13(4), RDH14(2), UGP2(5)	12895752	169	59	167	61	45	68	22	14	20	0	0.070	0.34
129	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(3), CD3D(3), CD3E(1), CD3G(1), IFNG(5), IL2(2), IL2RA(2), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TGFBR2(6), TGFBR3(8), TOB1(2), TOB2(5)	3856896	56	30	56	22	11	27	8	3	7	0	0.071	0.34
130	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	9	ANPEP(11), CKM(2), EIF4E(2), FBL(2), LDHA(6), LDHB(2), LDHC(4), MAPK14(4), NCL(3)	3089336	36	26	36	19	9	12	4	4	5	2	0.072	0.34
131	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(3), LPL(9), NR3C1(11), PPARG(5), RETN(1), RXRA(1)	2049472	30	21	30	6	10	8	2	2	8	0	0.074	0.35
132	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	ATF2(6), CHUK(7), IFNG(5), IKBKB(8), IL2(2), JUN(1), MAP3K1(24), MAP3K5(19), MAP4K5(6), MAPK14(4), MAPK8(7), NFKB1(7), NFKBIA(2), RELA(4), TNFRSF9(1), TRAF2(2)	7099496	105	37	101	30	24	43	10	8	18	2	0.074	0.35
133	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	38	APAF1(11), BAK1(3), BAX(3), BCL2L1(3), BID(2), BIRC2(10), BIRC3(2), CASP2(4), CASP3(3), CASP6(3), CASP7(4), CASP9(2), CYCS(2), FAS(6), FASLG(5), GZMB(2), JUN(1), MAP2K4(4), MAP3K1(24), MAP3K14(4), MAPK10(7), MCL1(1), MDM2(3), MYC(6), NFKB1(7), NFKBIA(2), PARP1(9), PRF1(6), RELA(4), RIPK1(8), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(2)	12470928	163	52	159	40	41	54	26	16	22	4	0.075	0.35
134	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(11), GBA(3), GBA3(7), LPO(4), MPO(6), PRDX6(2), TPO(11)	2960624	44	27	44	20	16	15	6	1	6	0	0.076	0.35
135	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), IL2(2), IL2RA(2), IL2RB(1), IL2RG(11), JAK1(16), JAK3(5), JUN(1), LCK(3), MAP2K1(2), MAPK3(3), MAPK8(7), RAF1(5), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3), SYK(3)	8416128	95	45	92	23	28	38	12	6	11	0	0.077	0.35
136	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(12), ADRB2(5), GNAS(16), PLCE1(31), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3)	4951568	85	37	81	22	19	35	15	4	12	0	0.077	0.35
137	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	53	APC(36), AXIN1(7), CCND2(7), CCND3(3), CSNK1E(3), DVL2(5), DVL3(7), FBXW2(3), FOSL1(3), FZD1(3), FZD10(6), FZD2(5), FZD3(5), FZD6(11), FZD7(4), FZD9(5), GSK3B(8), JUN(1), LDLR(6), MAPK10(7), MAPK9(4), MYC(6), PAFAH1B1(1), PLAU(4), PPP2R5C(4), PPP2R5E(5), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCI(6), PRKCQ(6), PRKCZ(3), PRKD1(6), RAC1(1), RHOA(3), SFRP4(9), TCF7(3), WNT1(1), WNT10A(1), WNT10B(1), WNT11(3), WNT16(4), WNT2(2), WNT2B(7), WNT3(3), WNT4(1), WNT5A(4), WNT5B(3), WNT7A(2), WNT7B(1)	18906776	260	71	252	104	75	98	33	19	29	6	0.080	0.36
138	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	103	A4GNT(5), ALG1(1), ALG10(6), ALG10B(6), ALG11(4), ALG13(13), ALG14(2), ALG3(1), ALG6(3), ALG8(5), ALG9(5), B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT4(3), B4GALT5(2), B4GALT7(3), C1GALT1(2), C1GALT1C1(4), CHPF(3), CHST1(8), CHST11(7), CHST12(3), CHST14(2), CHST2(1), CHST3(3), CHST4(1), CHST7(4), DAD1(1), DDOST(3), DPAGT1(2), EXT1(10), EXT2(6), EXTL1(9), EXTL2(7), EXTL3(6), FUT11(4), FUT8(12), GALNT1(8), GALNT10(4), GALNT11(12), GALNT12(2), GALNT13(14), GALNT14(4), GALNT2(5), GALNT3(6), GALNT4(7), GALNT5(5), GALNT6(1), GALNT7(9), GALNT8(9), GALNTL1(7), GALNTL2(11), GALNTL4(4), GALNTL5(9), GANAB(8), GCNT1(3), GCNT3(3), HS2ST1(5), HS3ST1(4), HS3ST2(3), HS3ST3A1(2), HS3ST5(9), HS6ST2(9), HS6ST3(2), MAN1A1(10), MAN1A2(5), MAN1B1(3), MAN1C1(6), MAN2A1(14), MGAT1(2), MGAT2(4), MGAT3(3), MGAT4A(3), MGAT4B(5), MGAT5(7), MGAT5B(6), NDST1(11), NDST2(4), NDST3(12), NDST4(11), OGT(13), RPN1(2), RPN2(5), ST3GAL1(1), ST3GAL2(3), ST3GAL3(4), ST3GAL4(3), ST6GAL1(6), ST6GALNAC1(2), STT3B(3), UST(3), WBSCR17(11), XYLT1(10), XYLT2(3)	38453144	517	91	495	162	129	213	89	24	58	4	0.082	0.36
139	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	11	CNR1(6), CNR2(3), DNMT1(11), MTNR1A(4), MTNR1B(3), PTAFR(4), PTGDR(6), PTGER2(2), PTGER4(7), PTGFR(9), PTGIR(2)	3602696	57	32	55	22	14	28	8	4	3	0	0.082	0.36
140	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(1), FOSB(4), GRIA2(17), PPP1R1B(2)	1266536	24	17	23	5	4	8	5	0	7	0	0.083	0.36
141	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2	FAH(5), GSTZ1(4)	480872	9	8	9	1	0	6	1	1	1	0	0.084	0.37
142	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	19	BAD(2), BAX(3), CYCS(2), MAP2K1(2), MAP2K4(4), MAP3K1(24), MAPK1(2), MAPK3(3), MAPK8(7), NFKB1(7), NSMAF(7), RAF1(5), RELA(4), RIPK1(8), SMPD1(10), TNFRSF1A(4), TRAF2(2)	6858192	96	39	94	16	21	33	16	5	19	2	0.084	0.37
143	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(4), CSF1(3), IL6(4), LDLR(6), LPL(9)	1946552	26	20	26	6	8	9	3	1	5	0	0.086	0.37
144	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(5), ALDH3A1(2), ALDH3B2(5), AOC2(6), AOC3(9), DDC(9), EPX(11), GOT1(5), GOT2(3), HPD(7), LPO(4), MAOA(10), MAOB(5), MPO(6), PRDX2(4), PRDX5(1), PRDX6(2), TAT(5), TPO(11)	7821672	110	41	104	42	28	38	16	9	19	0	0.091	0.39
145	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	117	ABL1(5), ABLIM1(6), ABLIM2(4), ABLIM3(5), ARHGEF12(19), CDC42(4), CDK5(1), CFL1(1), CFL2(7), CXCL12(2), CXCR4(1), DPYSL2(9), DPYSL5(4), EFNA1(1), EFNA3(1), EFNA4(3), EFNA5(1), EFNB1(4), EFNB3(1), EPHA1(8), EPHA2(3), EPHA3(11), EPHA4(14), EPHA6(17), EPHA7(8), EPHA8(9), EPHB1(19), EPHB2(8), EPHB3(2), EPHB4(3), EPHB6(7), FES(14), FYN(6), GNAI1(4), GNAI2(4), GNAI3(3), GSK3B(8), ITGB1(5), L1CAM(13), LIMK1(6), LIMK2(10), LRRC4C(9), MAPK1(2), MAPK3(3), MET(9), NCK1(4), NCK2(7), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NGEF(10), NRP1(11), NTN1(3), NTN4(4), NTNG1(8), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PLXNA1(20), PLXNA2(21), PLXNA3(14), PLXNB1(10), PLXNC1(23), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PTK2(8), RAC1(1), RAC2(2), RGS3(8), RHOA(3), RND1(5), ROBO1(17), ROBO2(15), ROBO3(9), ROCK1(15), ROCK2(10), SEMA3A(6), SEMA3B(4), SEMA3C(9), SEMA3D(8), SEMA3E(5), SEMA3F(5), SEMA3G(3), SEMA4A(4), SEMA4B(3), SEMA4C(7), SEMA4D(6), SEMA4F(10), SEMA4G(3), SEMA5A(15), SEMA5B(6), SEMA6A(7), SEMA6C(2), SEMA6D(16), SEMA7A(9), SLIT1(10), SLIT2(22), SLIT3(18), SRGAP1(15), SRGAP2(9), SRGAP3(7), UNC5A(8), UNC5B(5), UNC5C(7), UNC5D(11)	63747656	824	111	797	285	225	315	124	36	118	6	0.099	0.41
146	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(5), CR1(18), CR2(19), FCGR2B(3), ICAM1(1), ITGAL(12), ITGB2(10), PTPRC(11)	5514032	79	37	79	22	23	32	10	3	9	2	0.099	0.41
147	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ATP6V0C(1), CAT(3), EPX(11), LPO(4), MPO(6), PRDX2(4), PRDX5(1), PRDX6(2), SHMT1(4), SHMT2(2), TPO(11)	4054056	49	31	49	22	15	21	6	1	6	0	0.100	0.41
148	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(12), DYRK1B(2), GLI2(7), GLI3(14), GSK3B(8), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), SHH(4), SMO(5), SUFU(3)	5711192	76	35	75	36	22	34	5	4	9	2	0.10	0.41
149	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(7), CYP11A1(7), CYP11B1(4), CYP11B2(5), CYP17A1(1), CYP21A2(6), HSD11B1(3), HSD3B1(1), HSD3B2(5)	3288232	44	25	44	17	8	19	4	3	10	0	0.10	0.41
150	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(5), AKR1D1(7), CYP11A1(7), CYP11B1(4), CYP11B2(5), CYP17A1(1), CYP21A2(6), HSD11B1(3), HSD3B1(1), HSD3B2(5)	3288232	44	25	44	17	8	19	4	3	10	0	0.10	0.41
151	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	17	CSNK2A1(7), ELK1(2), FOS(2), GRB2(3), IGF1(2), IGF1R(10), IRS1(10), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(7), PTPN11(5), RAF1(5), SHC1(5), SOS1(10), SRF(2)	6774120	76	40	73	20	21	32	11	6	6	0	0.10	0.41
152	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	8	ALDOA(4), CTSD(3), GREB1(14), HSPB2(1), MTA1(4), MTA3(4), PDZK1(3), TUBA8(7)	3192752	40	27	40	12	11	19	3	4	3	0	0.10	0.41
153	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(5), ALOX15(7), ALOX5(6), CBR1(1), CBR3(1), CYP4F2(8), CYP4F3(7), EPX(11), GGT1(5), LPO(4), LTA4H(4), MPO(6), PLA2G2E(3), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PRDX2(4), PRDX5(1), PRDX6(2), PTGDS(4), PTGES2(2), PTGIS(6), PTGS1(5), PTGS2(6), TBXAS1(4), TPO(11)	9577512	134	49	131	48	39	61	17	4	13	0	0.10	0.41
154	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(3), CD4(6)	898752	9	9	9	4	1	5	0	0	3	0	0.10	0.41
155	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(42), CDC25A(7), CDC25B(2), CDC25C(5), CHEK1(2), WEE1(1), YWHAH(2)	4999184	61	31	58	10	13	17	13	0	14	4	0.10	0.42
156	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(10), ACO2(5), CS(5), DLD(3), DLST(8), FH(8), IDH1(3), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(6), MDH1(2), MDH2(4), PC(9), PCK1(8), SDHA(10), SDHB(1), SUCLA2(5), SUCLG1(3), SUCLG2(10)	7464056	108	44	107	46	32	46	13	8	9	0	0.11	0.42
157	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(4), ANXA2(1), ANXA3(3), ANXA4(8), ANXA5(2), ANXA6(8), CYP11A1(7), EDN1(2), EDNRA(5), HPGD(2), HSD11B1(3), PLA2G4A(9), PRL(4), PTGDR(6), PTGDS(4), PTGER2(2), PTGER4(7), PTGFR(9), PTGIR(2), PTGIS(6), PTGS1(5), PTGS2(6), SCGB1A1(1), TBXAS1(4)	7501256	110	42	110	30	33	40	15	7	15	0	0.11	0.42
158	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	24	BRAF(9), CPEB1(7), EGFR(10), ERBB2(3), ERBB4(19), ETS1(4), ETS2(5), ETV6(5), ETV7(3), GRB2(3), MAP2K1(2), MAPK1(2), MAPK3(3), NOTCH2(9), NOTCH3(20), NOTCH4(10), PIWIL1(13), PIWIL2(13), PIWIL3(7), PIWIL4(9), RAF1(5), SOS1(10), SOS2(16), SPIRE1(6)	15910192	193	62	185	35	44	78	35	12	22	2	0.11	0.42
159	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(2), AKT1(3), AKT2(4), AKT3(7), BAD(2), BTK(4), CDKN2A(1), DAPP1(7), GRB2(3), GSK3A(8), GSK3B(8), IARS(7), IGFBP1(4), INPP5D(9), PDK1(2), PPP1R13B(5), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KB1(2), SHC1(5), SOS1(10), SOS2(16), TEC(5), YWHAE(2), YWHAG(3), YWHAH(2), YWHAQ(1), YWHAZ(1)	11935992	153	55	145	43	41	59	23	8	20	2	0.11	0.42
160	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	79	ATF2(6), BRAF(9), CHUK(7), CREB1(5), DAXX(6), ELK1(2), FOS(2), GRB2(3), IKBKB(8), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K5(2), MAP2K6(6), MAP3K1(24), MAP3K10(6), MAP3K11(5), MAP3K12(6), MAP3K13(11), MAP3K14(4), MAP3K2(8), MAP3K3(6), MAP3K4(16), MAP3K5(19), MAP3K6(4), MAP3K7(8), MAP3K8(6), MAP3K9(3), MAP4K1(9), MAP4K2(6), MAP4K3(14), MAP4K4(7), MAP4K5(6), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK4(3), MAPK6(7), MAPK7(11), MAPK8(7), MAPK9(4), MAPKAPK2(4), MAPKAPK3(2), MAPKAPK5(4), MAX(4), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), MKNK1(3), MKNK2(3), MYC(6), NFKB1(7), NFKBIA(2), PAK1(1), PAK2(3), RAC1(1), RAF1(5), RELA(4), RIPK1(8), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA4(1), RPS6KA5(7), RPS6KB1(2), RPS6KB2(4), SHC1(5), SP1(6), STAT1(12), TGFB1(2), TGFB2(5), TGFB3(8), TGFBR1(3), TRAF2(2)	33131560	449	89	441	115	105	190	53	29	68	4	0.11	0.42
161	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	24	ADRBK1(4), AKT1(3), AKT2(4), AKT3(7), DAG1(4), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PDK1(2), PHKA2(12), PIK3CB(13), PLD1(9), PLD2(7), PLD3(2), VN1R1(4)	15569192	166	58	163	64	38	72	19	8	27	2	0.11	0.42
162	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	21	GH1(2), GHR(8), GRB2(3), INSR(12), IRS1(10), JAK2(14), MAP2K1(2), MAPK1(2), MAPK3(3), PLCG1(8), PRKCA(7), RAF1(5), RPS6KA1(1), SHC1(5), SLC2A4(5), SOS1(10), SRF(2), STAT5A(2), STAT5B(3)	10402360	104	50	101	38	25	41	19	7	8	4	0.11	0.42
163	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(5), IFNG(5), IL12A(5), IL12B(2), IL18(1), IL2(2)	1135344	20	16	19	6	6	7	3	2	2	0	0.11	0.42
164	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	70	ARAF(8), BRAF(9), CACNA1A(15), CRHR1(2), GNA11(2), GNA12(7), GNA13(7), GNAI1(4), GNAI2(4), GNAI3(3), GNAO1(4), GNAS(16), GNAZ(4), GRIA1(11), GRIA2(17), GRIA3(18), GRID2(9), GRM1(18), GRM5(19), GUCY1A2(9), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(6), GUCY2F(21), IGF1(2), IGF1R(10), ITPR1(23), ITPR2(25), ITPR3(15), LYN(6), MAP2K1(2), MAPK1(2), MAPK3(3), NOS1(14), NOS3(6), NPR1(10), NPR2(10), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PPP2CA(4), PPP2CB(2), PPP2R1B(5), PPP2R2A(10), PPP2R2B(7), PPP2R2C(2), PRKCA(7), PRKCG(6), PRKG1(4), PRKG2(8), RAF1(5), RYR1(59)	38637160	551	97	537	189	145	234	88	19	61	4	0.11	0.43
165	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	40	CHUK(7), DAXX(6), EGF(17), EGFR(10), ETS1(4), ETS2(5), FOS(2), IKBKB(8), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K1(24), MAP3K14(4), MAP3K5(19), MAPK1(2), MAPK13(2), MAPK14(4), MAPK3(3), MAPK8(7), NFKB1(7), NFKBIA(2), PPP2CA(4), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCQ(6), RAF1(5), RELA(4), RIPK1(8), SP1(6), TNFRSF1A(4), TNFRSF1B(1), TRAF2(2)	17165072	224	60	220	68	43	92	38	15	34	2	0.12	0.43
166	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(9), GOT1(5), GOT2(3), TAT(5), TYR(8)	1696816	30	19	30	3	5	14	5	4	2	0	0.12	0.43
167	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	35	AKT1(3), AKT2(4), AKT3(7), BAD(2), BCR(4), BLNK(3), BTK(4), CD19(3), CSK(1), DAG1(4), EPHB2(8), GRB2(3), ITPKB(7), LYN(6), MAP2K1(2), MAPK1(2), NFAT5(10), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PI3(2), PIK3CD(9), PLCG2(23), PPP1R13B(5), RAF1(5), SERPINA4(4), SHC1(5), SOS1(10), SOS2(16), SYK(3), VAV1(10)	16645016	190	61	185	78	54	76	29	11	18	2	0.12	0.43
168	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(17), EGFR(10), MAP2K1(2), MAP3K1(24), MAPK14(4), NCOR2(16), RARA(1), RXRA(1), THRA(4), THRB(2)	5496176	81	36	79	28	18	27	13	9	12	2	0.12	0.43
169	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(12), CD3D(3), CD3E(1), CD3G(1), CD4(6), CREBBP(24), CSK(1), GNAS(16), GNB1(1), LCK(3), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PTPRC(11), ZAP70(6)	7810512	106	44	102	33	21	50	12	5	18	0	0.12	0.43
170	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(12), CD3D(3), CD3E(1), CD3G(1), CD4(6), CREBBP(24), CSK(1), GNAS(16), GNB1(1), LCK(3), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PTPRC(11), ZAP70(6)	7810512	106	44	102	33	21	50	12	5	18	0	0.12	0.43
171	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(7), IKBKB(8), IL1R1(4), IRAK1(4), MAP3K1(24), MAP3K14(4), MAP3K7(8), MYD88(1), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), TLR4(13), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(1), TRAF6(3)	8543600	104	42	103	26	26	35	13	8	20	2	0.12	0.44
172	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(6), CDO1(4), CTH(4), GOT1(5), GOT2(3), LDHA(6), LDHAL6A(7), LDHAL6B(2), LDHB(2), LDHC(4), SDS(1), SULT1B1(4), SULT1C2(4), SULT1C4(3), SULT4A1(3)	4366784	58	32	55	29	20	16	10	6	6	0	0.12	0.44
173	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT2(1), AGPAT3(4), AGPAT4(3), AGPAT6(6), AGPS(9), CHPT1(1), ENPP2(18), ENPP6(8), PAFAH1B1(1), PAFAH1B2(2), PAFAH2(2), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLD1(9), PLD2(7), PPAP2A(4), PPAP2B(2)	7958568	106	43	103	29	23	48	11	4	18	2	0.12	0.44
174	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(4), IL6R(7), JAK1(16), JAK2(14), JAK3(5), PIAS3(7), PTPRU(12), REG1A(2), SRC(2), STAT3(8)	5459968	78	34	77	22	13	31	13	3	14	4	0.12	0.44
175	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(10), AP2A1(6), AP2M1(5), BIN1(3), CALM2(3), DNM1(4), EPN1(7), EPS15(8), PICALM(9), PPP3CA(2), PPP3CB(5), PPP3CC(4), SYNJ1(24), SYNJ2(8), SYT1(4)	7812248	102	43	99	41	27	38	16	5	16	0	0.13	0.44
176	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(4), ICAM1(1), ITGAL(12), ITGAM(19), ITGB2(10), SELE(5), SELL(3)	4301064	54	31	53	22	12	23	6	2	9	2	0.13	0.44
177	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	27	ACTA1(3), AKT1(3), BDKRB2(7), CALM2(3), CHRM1(3), CHRNA1(6), FLT1(15), FLT4(9), KDR(20), NOS3(6), PDE2A(11), PDE3A(14), PDE3B(9), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKG1(4), PRKG2(8), SLC7A1(6), SYT1(4), TNNI1(1)	10265464	153	47	150	49	36	67	18	6	26	0	0.13	0.44
178	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(12), AKT1(3), BAD(2), BAX(3), BCL2L1(3), CSF2RB(9), IGF1(2), IGF1R(10), IL3RA(8), KIT(22), KITLG(2), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), YWHAH(2)	6204216	99	38	98	33	26	45	11	7	10	0	0.13	0.44
179	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(3), CHUK(7), EGR2(4), EGR3(5), MAP3K1(24), MYC(6), NFATC2(9), NFKB1(7), NFKBIA(2), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RELA(4), SYT1(4), VIP(1)	9629096	116	45	113	35	29	46	11	12	16	2	0.13	0.45
180	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(42), CDC25A(7), CDC25B(2), CDC25C(5), CDK2(2), CDK4(3), CHEK1(2), WEE1(1), YWHAH(2)	5461704	66	32	63	12	13	19	16	0	14	4	0.13	0.45
181	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	35	AKT1(3), ATF2(6), CDC42(4), DLD(3), DUSP10(5), GAB1(5), GCK(3), IL1R1(4), JUN(1), MAP2K4(4), MAP2K5(2), MAP3K1(24), MAP3K10(6), MAP3K11(5), MAP3K12(6), MAP3K13(11), MAP3K2(8), MAP3K3(6), MAP3K4(16), MAP3K5(19), MAP3K7(8), MAP3K9(3), MAPK10(7), MAPK7(11), MAPK8(7), MAPK9(4), MYEF2(5), NFATC3(9), NR2C2(5), PAPPA(26), SHC1(5), TRAF6(3), ZAK(11)	17369424	245	64	242	74	77	90	29	11	34	4	0.13	0.45
182	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACA(27), ACACB(25), MCAT(2), OLAH(7), OXSM(5)	4386624	66	33	63	21	20	22	11	1	8	4	0.13	0.45
183	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	53	AK3(1), CAD(21), CANT1(1), CDA(1), CTPS(7), CTPS2(6), DCK(4), DCTD(4), DHODH(3), DPYD(11), DPYS(3), ENTPD1(2), NT5C(1), NT5E(5), NT5M(3), NUDT2(2), POLB(3), POLD1(11), POLD2(5), POLG(5), POLL(6), POLQ(18), POLR1B(10), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), RRM1(2), RRM2(5), TK1(1), TK2(6), TXNRD1(9), UCK1(5), UCK2(5), UMPS(5), UNG(1), UPB1(8), UPP1(3)	19896792	226	67	221	69	44	95	32	19	36	0	0.13	0.45
184	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	83	AICDA(2), AK3(1), CAD(21), CANT1(1), CDA(1), CTPS(7), CTPS2(6), DCK(4), DCTD(4), DHODH(3), DPYD(11), DPYS(3), ENTPD1(2), ENTPD3(4), ENTPD5(2), ENTPD6(8), NME7(2), NT5C(1), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(8), NT5E(5), NT5M(3), NUDT2(2), PNPT1(5), POLA1(23), POLA2(1), POLD1(11), POLD2(5), POLD3(4), POLD4(1), POLE2(2), POLE3(2), POLE4(1), POLR1A(11), POLR1B(10), POLR1C(2), POLR1D(1), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), POLR3A(5), POLR3B(6), POLR3G(2), POLR3GL(3), POLR3H(3), PRIM1(2), PRIM2(7), RFC5(7), RRM1(2), RRM2(5), RRM2B(4), TK1(1), TK2(6), TXNRD1(9), TXNRD2(4), UCK1(5), UCK2(5), UMPS(5), UPB1(8), UPP1(3), UPP2(4), UPRT(6)	28865960	336	78	327	111	70	130	52	28	56	0	0.14	0.45
185	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(5), FADS2(1), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7)	3519864	38	27	38	13	7	22	4	0	5	0	0.14	0.46
186	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(11), CD14(2), CD19(3), CD1A(5), CD1B(1), CD1C(11), CD1D(3), CD1E(5), CD2(4), CD22(11), CD33(6), CD34(1), CD36(5), CD37(1), CD38(5), CD3D(3), CD3E(1), CD3G(1), CD4(6), CD44(4), CD5(5), CD55(5), CD59(3), CD8A(2), CD8B(1), CD9(3), CR1(18), CR2(19), CSF1(3), CSF1R(6), CSF2RA(7), CSF3(1), CSF3R(7), DNTT(1), EPO(1), EPOR(3), FCGR1A(5), FLT3(7), FLT3LG(2), GP1BA(9), GP5(2), GYPA(1), HLA-DRB5(2), IL11RA(5), IL1B(2), IL1R1(4), IL1R2(5), IL2RA(2), IL3RA(8), IL4R(5), IL5(1), IL5RA(7), IL6(4), IL6R(7), IL7(1), IL7R(7), IL9R(1), ITGA1(13), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGAM(19), ITGB3(10), KIT(22), KITLG(2), MME(6), MS4A1(5), TFRC(3), THPO(5), TPO(11)	30199704	411	84	404	132	116	151	55	22	61	6	0.14	0.46
187	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	64	FAU(1), MRPS7(3), RPL10A(1), RPL10L(7), RPL11(1), RPL18(4), RPL18A(2), RPL19(2), RPL21(2), RPL22L1(3), RPL23A(4), RPL24(2), RPL27(1), RPL27A(3), RPL28(2), RPL29(2), RPL3(1), RPL35A(2), RPL36AL(1), RPL37(3), RPL38(1), RPL39(3), RPL3L(3), RPL6(2), RPL8(1), RPL9(1), RPS10(1), RPS12(2), RPS13(1), RPS15A(1), RPS18(3), RPS20(3), RPS21(1), RPS24(2), RPS25(1), RPS27(1), RPS29(2), RPS3(2), RPS3A(1), RPS6(6), RPS7(3), RPS8(2), RPS9(1)	7626496	91	41	86	29	16	46	17	3	9	0	0.14	0.46
188	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(7), DPM2(2), ELK1(2), FOS(2), GRB2(3), JUN(1), KLK2(2), MAP2K1(2), MAPK3(3), MAPK8(7), NGFR(3), PLCG1(8), RAF1(5), SHC1(5), SOS1(10)	5471128	62	35	58	11	19	24	10	5	4	0	0.14	0.46
189	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(5), ATM(42), BUB1(7), BUB1B(4), BUB3(2), CCNA1(3), CCNA2(2), CCNB1(7), CCNB2(3), CCNB3(19), CCND2(7), CCND3(3), CCNE2(5), CCNH(3), CDAN1(8), CDC14A(4), CDC14B(5), CDC20(4), CDC25A(7), CDC25B(2), CDC25C(5), CDC6(1), CDC7(10), CDH1(12), CDK2(2), CDK4(3), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(11), DTX4(4), E2F1(6), E2F2(2), E2F3(3), E2F4(2), E2F6(1), EP300(23), ESPL1(5), GSK3B(8), HDAC1(3), HDAC2(4), HDAC3(8), HDAC4(12), HDAC5(10), HDAC6(12), HDAC8(2), MAD1L1(11), MAD2L1(3), MAD2L2(2), MCM2(4), MCM3(8), MCM4(6), MCM5(7), MCM6(4), MCM7(3), MDM2(3), MPEG1(7), MPL(4), PCNA(2), PLK1(3), PRKDC(40), PTPRA(7), PTTG1(2), RBL1(13), SKP2(4), SMAD4(3), TBC1D8(9), TGFB1(2), WEE1(1)	39471680	443	89	429	132	96	191	65	17	64	10	0.15	0.47
190	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(12), ADRB2(5), CFTR(12), GNAS(16), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), SLC9A3R1(2)	4327104	68	32	64	16	16	31	7	3	11	0	0.15	0.47
191	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(3), AP2A1(6), AP2M1(5), ARF1(3), BAD(2), BTK(4), EEA1(16), GRASP(3), GSK3A(8), GSK3B(8), LYN(6), PDPK1(2), PFKM(4), PFKP(6), PLCG1(8), PRKCE(7), PRKCZ(3), RAB5A(1), RAC1(1), RPS6KB1(2), VAV2(3)	8307752	101	45	97	40	33	37	15	5	11	0	0.15	0.48
192	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(3)	187984	3	3	3	0	2	0	0	0	1	0	0.15	0.48
193	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	43	ACOX1(3), APOA2(1), CD36(5), CPT1B(1), CREBBP(24), DUSP1(2), EHHADH(4), EP300(23), FABP1(4), HSD17B4(8), JUN(1), LPL(9), MAPK1(2), MAPK3(3), ME1(7), MRPL11(1), MYC(6), NCOA1(15), NCOR1(16), NCOR2(16), NFKBIA(2), NR0B2(2), NR1H3(4), NR2F1(5), NRIP1(14), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PTGS2(6), RELA(4), RXRA(1), SP1(6), SRA1(1), STAT5A(2), STAT5B(3)	19286464	229	63	225	68	47	94	36	16	34	2	0.15	0.48
194	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(5), HSD3B7(3), RDH11(1), RDH12(3), RDH13(4), RDH14(2)	1712192	21	18	21	6	7	9	3	1	1	0	0.15	0.48
195	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	25	DUSP1(2), GORASP1(7), MAP2K4(4), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK8(7), MAPK8IP1(4), MAPK9(4), MAPKAPK5(4), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PIK3CD(9), SYT1(4), TRAF2(2), TRAF3(4), TRAF5(6), TRAF6(3)	8620976	103	46	102	28	22	49	11	4	15	2	0.15	0.48
196	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), APEX1(2), CREBBP(24), DFFB(3), GZMA(6), GZMB(2), HMGB2(4), PRF1(6), SET(4)	3740832	53	29	51	18	8	21	8	4	12	0	0.15	0.48
197	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(21), GNA12(7), PRKACG(7), PRKAG1(2), PRKAR2A(3), PRKAR2B(3)	3613856	43	29	41	14	8	18	5	4	8	0	0.16	0.49
198	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	GATA3(2), IL5(1), MAF(2), MAP2K3(7), MAPK14(4), NFATC2(9), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3)	3646096	46	27	45	17	6	23	4	6	7	0	0.16	0.49
199	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	90	AKT1(3), AKT2(4), AKT3(7), CCL4(1), CCL5(2), CD14(2), CD40(2), CD80(5), CD86(4), CHUK(7), CXCL10(2), CXCL9(2), FOS(2), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(6), IFNAR2(6), IFNB1(2), IKBKB(8), IKBKE(1), IL12A(5), IL12B(2), IL1B(2), IL6(4), IL8(3), IRAK1(4), IRAK4(5), IRF3(2), IRF5(5), JUN(1), LBP(2), LY96(3), MAP2K1(2), MAP2K3(7), MAP2K4(4), MAP2K6(6), MAP3K7(8), MAP3K8(6), MAPK1(2), MAPK10(7), MAPK13(2), MAPK14(4), MAPK3(3), MAPK8(7), MAPK9(4), MYD88(1), NFKB1(7), NFKB2(9), NFKBIA(2), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), RAC1(1), RELA(4), RIPK1(8), SPP1(2), STAT1(12), TBK1(5), TICAM1(6), TICAM2(4), TIRAP(2), TLR1(10), TLR2(11), TLR3(5), TLR4(13), TLR5(6), TLR6(9), TLR7(12), TLR8(16), TLR9(5), TRAF3(4), TRAF6(3)	29343608	404	84	396	114	100	159	62	22	59	2	0.16	0.49
200	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(3), AKT2(4), AKT3(7), CISH(1), GRB2(3), IARS(7), IL13RA1(10), IL2RG(11), IL4R(5), INPP5D(9), JAK1(16), JAK2(14), JAK3(5), NR0B2(2), PI3(2), PPP1R13B(5), RPS6KB1(2), SERPINA4(4), SHC1(5), SOS1(10), SOS2(16), SRC(2), STAT6(5), TYK2(4)	12500688	152	53	148	51	31	60	26	9	20	6	0.16	0.49
201	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	35	AKT1(3), ASAH1(6), ATF1(4), BRAF(9), CREB1(5), CREB5(3), CREBBP(24), CRKL(4), DAG1(4), EGR1(6), EGR2(4), EGR3(5), ELK1(2), FRS2(4), JUN(1), MAP1B(27), MAP2K4(4), MAPK1(2), MAPK10(7), MAPK3(3), MAPK8(7), MAPK8IP1(4), MAPK9(4), NTRK1(11), OPN1LW(4), PIK3C2G(12), PIK3CD(9), PTPN11(5), RPS6KA3(15), SHC1(5), SRC(2), TERF2IP(2)	15276552	207	58	204	66	50	91	27	10	24	5	0.16	0.49
202	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	72	ABL1(5), ACTN1(7), ACTR2(5), ACTR3(1), AKT1(3), AKT2(4), AKT3(7), ANGPTL2(4), ARHGEF6(16), ARHGEF7(11), BRAF(9), CDC42(4), CDKN2A(1), CRK(1), CSE1L(10), DOCK1(17), EPHB2(8), FYN(6), GRB2(3), GRB7(4), ILK(4), ITGA1(13), ITGA10(7), ITGA11(6), ITGA2(14), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGB3BP(2), MAP2K4(4), MAP3K11(5), MAPK1(2), MAPK10(7), MAPK8(7), MAPK8IP1(4), MAPK9(4), MRAS(1), MYLK(10), MYLK2(6), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PIK3CB(13), PKLR(5), PLCG1(8), PLCG2(23), PTK2(8), RAF1(5), RALA(3), RHO(3), ROCK1(15), ROCK2(10), SHC1(5), SOS1(10), SOS2(16), SRC(2), TERF2IP(2), TLN1(20), TLN2(20), VASP(1), WAS(8), ZYX(11)	41788744	503	96	486	157	128	187	76	28	78	6	0.16	0.49
203	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	52	ABP1(5), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), ALDH3A1(2), ALDH3B2(5), AOC2(6), AOC3(9), AOX1(14), CARM1(4), DBH(7), DCT(11), DDC(9), ECH1(2), ESCO1(8), ESCO2(5), FAH(5), GOT1(5), GOT2(3), GSTZ1(4), HEMK1(1), HPD(7), LCMT1(2), LCMT2(8), MAOA(10), MAOB(5), METTL2B(3), METTL6(3), NAT6(1), PNMT(1), PNPLA3(6), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), SH3GLB1(6), TAT(5), TPO(11), TYR(8), TYRP1(7), WBSCR22(5)	20674520	253	65	243	69	65	90	40	16	42	0	0.16	0.49
204	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT1(2), B4GALT2(3), G6PC(5), GAA(4), GALK1(1), GALK2(2), GALT(2), GANAB(8), GCK(3), GLA(2), GLB1(4), HK1(9), HK2(5), HK3(8), LALBA(1), LCT(24), MGAM(36), PFKM(4), PFKP(6), PGM1(5), PGM3(4)	11222992	139	52	138	57	38	55	18	10	18	0	0.16	0.49
205	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(7), DUSP1(2), IKBKAP(8), IKBKB(8), LTA(2), MAP3K1(24), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), TANK(2), TNFAIP3(2), TNFRSF1B(1), TRAF1(5), TRAF2(2), TRAF3(4)	8127952	92	39	91	23	21	38	7	8	16	2	0.16	0.49
206	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(12), GNAS(16), GNB1(1), PPP2CA(4), PRKAA1(5), PRKAA2(7), PRKAB1(6), PRKAB2(1), PRKACG(7), PRKAG1(2), PRKAG2(3), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3)	5127896	78	34	75	20	17	41	7	3	10	0	0.17	0.50
207	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	16	ADCY1(12), ARHGEF1(9), F2(8), F2R(6), GNA12(7), GNA13(7), GNAI1(4), GNB1(1), MAP3K7(8), PLCB1(4), PPP1R12B(11), PRKCA(7), PTK2B(13), ROCK1(15)	7733880	112	42	110	35	40	40	16	6	6	4	0.17	0.50
208	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(4), DLG4(10), EPHB2(8), F2(8), F2RL1(2), F2RL2(2), JUN(1), MAP2K5(2), MAPK1(2), MAPK7(11), MAPK8(7), MYEF2(5), PLD1(9), PLD2(7), PLD3(2), PTK2(8), RAF1(5), RASAL1(11), SRC(2), TEC(5), VAV1(10)	9655136	121	47	120	47	33	45	21	3	19	0	0.17	0.50
209	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	27	AKT1(3), AKT2(4), AKT3(7), ANKRD6(6), APC(36), AXIN1(7), CER1(2), CSNK1A1(4), DACT1(10), DKK1(3), DKK2(3), DKK3(1), DKK4(3), FSTL1(2), GSK3A(8), GSK3B(8), LRP1(36), MVP(11), NKD1(3), PSEN1(5), PTPRA(7), SENP2(6), SFRP1(5), TSHB(3), WIF1(4)	13253616	187	57	182	53	61	70	22	9	21	4	0.17	0.50
210	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CD2(4), CD3D(3), CD3E(1), CD3G(1), CD4(6), CXCR3(5), IFNG(5), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), JAK2(14), STAT4(6), TYK2(4)	5174520	75	33	74	26	13	28	11	7	12	4	0.18	0.52
211	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(5), BMP4(7), BMP5(12), BMP6(4), BMP7(10), BMP8A(3), BMP8B(1), BTRC(11), CSNK1A1(4), CSNK1A1L(2), CSNK1E(3), CSNK1G1(5), CSNK1G3(6), DHH(2), FBXW11(4), GLI1(8), GLI2(7), GLI3(14), GSK3B(8), HHIP(11), IHH(3), LRP2(61), PRKACA(4), PRKACG(7), PRKX(2), PTCH1(17), PTCH2(12), RAB23(2), SHH(4), SMO(5), STK36(6), SUFU(3), WNT1(1), WNT10A(1), WNT10B(1), WNT11(3), WNT16(4), WNT2(2), WNT2B(7), WNT3(3), WNT4(1), WNT5A(4), WNT5B(3), WNT7A(2), WNT7B(1), WNT8A(1), WNT8B(3), WNT9A(1), WNT9B(1), ZIC2(1)	20735280	293	72	285	95	98	118	36	11	30	0	0.18	0.52
212	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(3), EPX(11), LPO(4), MPO(6), MTHFR(5), PRDX6(2), SHMT1(4), SHMT2(2), TPO(11)	4035952	48	29	48	20	15	18	6	1	8	0	0.18	0.52
213	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	88	ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), AKAP1(7), AKAP10(7), AKAP11(22), AKAP12(14), AKAP3(13), AKAP5(1), AKAP6(26), AKAP7(4), AKAP8(3), AKAP9(43), ARHGEF1(9), CALM2(3), CHMP1B(1), GNA11(2), GNA12(7), GNA13(7), GNA14(5), GNA15(1), GNAI2(4), GNAI3(3), GNAL(6), GNAO1(4), GNAZ(4), GNB1(1), GNB2(6), GNB5(1), GNG12(1), GNG3(2), GNGT2(2), ITPR1(23), KCNJ3(9), PALM2(5), PDE1A(10), PDE1B(6), PDE1C(10), PDE4A(9), PDE4B(12), PDE4C(2), PDE4D(7), PDE7B(5), PDE8A(5), PDE8B(15), PLCB3(9), PPP3CA(2), PPP3CC(4), PRKACA(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCI(6), PRKCQ(6), PRKCZ(3), PRKD1(6), PRKD3(9), RHOA(3), RRAS(1), SLC9A1(6), USP5(11)	41332920	541	91	528	195	145	201	85	32	71	7	0.18	0.52
214	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	24	ARHGDIB(1), BAG4(3), CASP2(4), CASP3(3), CRADD(2), DFFB(3), JUN(1), LMNA(5), LMNB1(4), MADD(15), MAP2K4(4), MAP3K1(24), MAP3K7(8), MAPK8(7), PAK1(1), PAK2(3), PRKDC(40), RIPK1(8), SPTAN1(23), TNFRSF1A(4), TRAF2(2)	12949568	165	52	162	52	42	57	22	11	31	2	0.18	0.52
215	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	10	AKT1(3), CAT(3), GH1(2), GHR(8), IGF1(2), IGF1R(10), SHC1(5), SOD1(2), SOD2(3)	3331880	38	26	38	16	6	18	7	4	3	0	0.18	0.52
216	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	44	AKT1(3), AKT2(4), AKT3(7), BRD4(7), CAP1(7), CBL(8), CDC42(4), CDKN2A(1), F2RL2(2), FLOT2(1), GRB2(3), GSK3A(8), GSK3B(8), IGFBP1(4), IRS1(10), IRS4(16), LNPEP(6), MAPK1(2), MAPK3(3), PARD3(19), PDK1(2), PIK3CD(9), PPYR1(6), PTPN1(4), RAF1(5), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KB1(2), SERPINB6(2), SHC1(5), SLC2A4(5), SORBS1(14), SOS1(10), SOS2(16), YWHAE(2), YWHAG(3), YWHAH(2), YWHAQ(1), YWHAZ(1)	18354232	242	68	232	79	67	88	45	11	29	2	0.19	0.53
217	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(3), PLCB1(4), PLCG1(8), PRKCA(7), VAV1(10)	3324440	32	26	31	23	8	11	6	4	3	0	0.19	0.53
218	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4), IL8(3), SLPI(2)	633144	9	9	8	0	3	3	2	0	1	0	0.19	0.53
219	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	86	AKT1(3), AKT3(7), CAPN1(2), CAPN10(7), CAPN11(6), CAPN2(5), CAPN3(8), CAPN5(6), CAPN6(4), CAPN7(4), CAPN9(8), CAPNS1(1), CAV2(1), CDC42(4), CRK(1), CSK(1), DOCK1(17), FYN(6), GIT2(6), GRB2(3), ILK(4), ITGA10(7), ITGA11(6), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGAD(5), ITGAE(7), ITGAL(12), ITGAM(19), ITGAV(6), ITGAX(7), ITGB1(5), ITGB2(10), ITGB3(10), ITGB4(6), ITGB5(4), ITGB6(4), ITGB7(4), ITGB8(4), MAP2K1(2), MAP2K3(7), MAP2K6(6), MAPK10(7), MAPK4(3), MAPK6(7), MAPK7(11), MYLK2(6), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PDPK1(2), PIK3R2(3), PTK2(8), PXN(4), RAC1(1), RAC2(2), RAP1B(2), RAPGEF1(9), RHO(3), ROCK1(15), ROCK2(10), SDCCAG8(11), SEPP1(3), SHC1(5), SHC3(9), SORBS1(14), SOS1(10), SRC(2), TLN1(20), TNS1(15), VASP(1), VAV2(3), VAV3(9), VCL(8), ZYX(11)	47185968	557	97	543	216	154	216	74	30	73	10	0.19	0.53
220	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	123	ACTB(3), ACTG1(1), CHAD(1), COL11A1(22), COL11A2(6), COL17A1(18), COL1A1(7), COL1A2(15), COL2A1(10), COL3A1(12), COL4A1(15), COL4A2(5), COL4A4(17), COL4A6(28), COL5A2(17), COL5A3(17), COL6A3(34), COL6A6(20), COMP(3), DES(5), DSC2(11), DSG1(15), DSG2(7), DSG4(10), FN1(31), GJA1(5), GJA10(6), GJA4(1), GJA8(5), GJA9(10), GJB1(1), GJB2(2), GJB3(2), GJB4(3), GJB5(2), GJB6(3), GJB7(6), GJC1(1), GJC3(2), GJD2(6), GJD4(3), IBSP(5), INA(3), ITGA6(10), ITGB4(6), KRT1(3), KRT10(1), KRT12(5), KRT13(5), KRT14(4), KRT15(8), KRT16(5), KRT17(4), KRT19(3), KRT2(6), KRT20(4), KRT23(7), KRT24(5), KRT25(4), KRT27(4), KRT28(3), KRT3(7), KRT31(8), KRT32(6), KRT33A(7), KRT33B(2), KRT34(8), KRT35(6), KRT36(6), KRT37(5), KRT38(8), KRT4(10), KRT5(4), KRT6A(3), KRT6B(8), KRT6C(5), KRT7(2), KRT71(3), KRT72(5), KRT73(3), KRT74(1), KRT75(4), KRT76(5), KRT77(4), KRT78(2), KRT79(3), KRT8(2), KRT81(1), KRT82(1), KRT83(2), KRT84(5), KRT85(4), KRT86(1), KRT9(7), LAMA1(27), LAMA2(52), LAMA3(22), LAMA4(13), LAMB1(21), LAMB2(20), LAMB3(12), LAMB4(22), LAMC1(13), LAMC2(11), LAMC3(10), LMNA(5), LMNB1(4), NES(26), RELN(36), SPP1(2), THBS1(9), THBS3(2), THBS4(6), TNC(14), TNN(11), TNR(11), TNXB(16), VIM(7), VWF(19)	79795984	1022	126	1000	337	290	420	133	46	109	24	0.19	0.53
221	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(5), CREM(3), FOS(2), JUN(1), MAPK3(3), OPRK1(6), POLR2A(17), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3)	4489296	58	31	57	18	11	30	6	4	7	0	0.19	0.53
222	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	26	AKT1(3), CABIN1(11), CALM2(3), CAMK1(2), CAMK1G(3), HDAC5(10), IGF1(2), IGF1R(10), INSR(12), MAP2K6(6), MAPK14(4), MAPK7(11), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), MYOD1(3), NFATC2(9), PPP3CA(2), PPP3CB(5), PPP3CC(4), SYT1(4), YWHAH(2)	10331680	123	46	123	47	26	58	16	7	16	0	0.19	0.54
223	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	63	A2M(16), BDKRB1(2), BDKRB2(7), C1QA(4), C1QB(2), C1QC(4), C1R(9), C1S(5), C2(3), C3(18), C3AR1(7), C4BPA(6), C4BPB(2), C5(14), C5AR1(3), C6(13), C7(16), C8A(9), C8B(3), CD46(1), CD55(5), CD59(3), CFB(3), CFH(15), CFI(6), CPB2(6), CR1(18), CR2(19), F10(9), F11(9), F12(2), F13A1(7), F13B(13), F2(8), F2R(6), F3(6), F5(36), F7(1), F8(34), F9(10), FGA(23), FGB(4), FGG(9), KLKB1(10), KNG1(7), MASP1(9), MASP2(5), MBL2(3), PLAT(5), PLAU(4), PLAUR(5), PLG(9), PROC(3), PROS1(1), SERPINA1(3), SERPINA5(3), SERPINC1(5), SERPIND1(4), SERPINE1(5), SERPINF2(4), SERPING1(6), TFPI(7), VWF(19)	32070616	513	84	490	150	138	214	67	26	60	8	0.20	0.54
224	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	34	EEF1B2(3), EEF1D(7), EEF1G(3), EEF2(9), EEF2K(7), EIF1AX(1), EIF2AK1(7), EIF2AK2(13), EIF2AK3(11), EIF2B2(4), EIF2B3(7), EIF2B4(3), EIF2B5(4), EIF2S2(5), EIF2S3(5), EIF4A1(4), EIF4A2(4), EIF4E(2), EIF4EBP2(1), EIF4G1(10), EIF4G3(18), EIF5(2), EIF5A(4), EIF5B(12), ETF1(4), GSPT2(14), PABPC1(8), PABPC3(7), PAIP1(3), SLC35A4(4)	14600256	186	61	183	43	48	73	29	8	26	2	0.20	0.54
225	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(3), CD4(6), CD80(5), IL10(2), IL2(2)	1493952	18	13	18	9	4	8	3	0	3	0	0.20	0.54
226	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(10), IL13RA2(3), IL4R(5), JAK1(16), JAK2(14), TYK2(4)	3800848	52	26	52	17	8	15	12	4	9	4	0.20	0.54
227	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(10), IL13RA2(3), IL4R(5), JAK1(16), JAK2(14), TYK2(4)	3800848	52	26	52	17	8	15	12	4	9	4	0.20	0.54
228	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	8	CREB1(5), FOS(2), JUN(1), KEAP1(7), MAPK1(2), MAPK14(4), MAPK8(7), PRKCA(7)	2560352	35	22	35	8	6	12	4	5	8	0	0.20	0.54
229	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	106	ATP12A(13), ATP4A(6), ATP5A1(7), ATP5B(3), ATP5C1(1), ATP5E(1), ATP5F1(4), ATP5G1(2), ATP5G2(1), ATP5I(1), ATP5J(3), ATP5L(1), ATP6AP1(6), ATP6V0A1(5), ATP6V0A2(10), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(7), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1D(2), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), COX10(1), COX15(3), COX4I1(2), COX5A(1), COX5B(1), COX6A1(3), COX6B1(1), COX6C(2), COX7A1(2), COX7B(3), COX7B2(2), COX7C(2), COX8A(1), COX8C(1), CYC1(1), LHPP(2), NDUFA1(1), NDUFA10(6), NDUFA13(1), NDUFA2(3), NDUFA3(4), NDUFA4(1), NDUFA4L2(1), NDUFA5(4), NDUFA6(2), NDUFA8(5), NDUFA9(3), NDUFAB1(1), NDUFB1(1), NDUFB10(1), NDUFB8(1), NDUFC1(1), NDUFC2(1), NDUFS1(10), NDUFS2(4), NDUFS4(2), NDUFS5(1), NDUFS8(2), NDUFV1(2), NDUFV2(2), PPA1(3), PPA2(3), SDHA(10), SDHB(1), SDHC(4), TCIRG1(5), UQCRB(3), UQCRC1(2), UQCRC2(4), UQCRQ(2)	19236368	257	68	253	65	68	115	23	14	37	0	0.20	0.55
230	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(3), ARSB(4), FUCA1(2), FUCA2(3), GBA(3), GLB1(4), GNS(1), GUSB(4), HEXA(1), HEXB(3), HGSNAT(7), HPSE(3), HPSE2(5), HYAL1(2), HYAL2(2), IDS(5), LCT(24), MAN2B1(11), MAN2B2(4), MAN2C1(6), MANBA(12), NAGLU(2), NEU2(4), NEU3(2), SPAM1(11)	11804304	128	49	127	56	33	59	17	8	11	0	0.20	0.55
231	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	88	CD2BP2(2), CDC40(7), CLK2(7), CLK3(4), CLK4(5), COL2A1(10), CPSF1(7), CPSF2(10), CPSF3(6), CPSF4(1), CSTF1(3), CSTF2(10), CSTF2T(4), CSTF3(9), DDIT3(1), DDX1(3), DDX20(4), DHX15(6), DHX16(9), DHX38(6), DHX8(6), DHX9(11), DICER1(27), DNAJC8(1), FUS(2), GIPC1(1), METTL3(5), NCBP1(8), NCBP2(2), NONO(11), NXF1(3), PABPN1(1), PAPOLA(9), PHF5A(1), POLR2A(17), PPM1G(6), PRPF18(4), PRPF3(8), PRPF4(4), PRPF4B(15), PRPF8(17), PSKH1(6), PTBP1(1), PTBP2(6), RBM17(4), RBM5(4), RNGTT(8), RNMT(6), SF3A1(3), SF3A3(5), SF3B1(15), SF3B2(7), SF3B4(3), SF3B5(2), SNRPA(2), SNRPB(2), SNRPB2(1), SNRPD1(1), SNRPD2(1), SNRPD3(2), SNRPE(1), SNRPG(1), SRPK1(10), SRPK2(5), SRRM1(8), SUPT5H(15), U2AF1(3), U2AF2(5), XRN2(13)	37397904	413	91	401	123	118	154	61	30	50	0	0.21	0.55
232	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX15(7), ALOX5(6), CYP1A2(5), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2E1(1), CYP2J2(2), CYP3A4(9), CYP3A43(3), CYP3A5(4), CYP3A7(6), HSD3B7(3), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), RDH11(1), RDH12(3), RDH13(4), RDH14(2)	8490776	105	44	104	28	29	39	18	4	15	0	0.21	0.56
233	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	58	AKT1(3), AKT2(4), AKT3(7), BAD(2), BCL2L1(3), CDC42(4), CDK2(2), CDKN2A(1), CREB1(5), CREB5(3), ERBB4(19), F2RL2(2), GAB1(5), GRB2(3), GSK3A(8), GSK3B(8), IGF1(2), IGFBP1(4), IRS1(10), IRS4(16), MET(9), MYC(6), NOLC1(10), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PARD3(19), PDK1(2), PIK3CD(9), PPP1R13B(5), PREX1(17), PTK2(8), PTPN1(4), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KB1(2), SHC1(5), SLC2A4(5), SOS1(10), SOS2(16), TSC1(9), TSC2(13), YWHAE(2), YWHAG(3), YWHAH(2), YWHAQ(1), YWHAZ(1)	24427008	324	75	314	104	75	130	58	20	39	2	0.22	0.57
234	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(12), ADCY8(15), ARAF(8), ATF4(3), BRAF(9), CACNA1C(21), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), CREBBP(24), EP300(23), GRIA1(11), GRIA2(17), GRIN1(3), GRIN2A(18), GRIN2B(18), GRIN2C(5), GRIN2D(5), GRM1(18), GRM5(19), ITPR1(23), ITPR2(25), ITPR3(15), MAP2K1(2), MAPK1(2), MAPK3(3), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PPP1CA(3), PPP1CB(4), PPP1CC(2), PPP1R12A(8), PPP1R1A(3), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKX(2), RAF1(5), RAP1A(3), RAP1B(2), RAPGEF3(7), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA6(12)	35773256	475	90	464	168	109	194	88	18	64	2	0.22	0.58
235	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	13	ADSL(5), ADSS(6), DHFR(3), HPRT1(2), IMPDH1(5), MTHFD2(2), POLB(3), POLD1(11), POLG(5), PRPS2(6), RRM1(2), SRM(1)	4275768	51	29	50	19	14	23	6	4	4	0	0.22	0.58
236	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	23	ABAT(9), ALDH4A1(1), ALDH5A1(5), CAD(21), CPS1(19), EPRS(7), GAD1(6), GAD2(10), GCLC(5), GCLM(2), GFPT1(8), GLS(9), GLS2(6), GLUD1(3), GLUL(6), GMPS(11), GOT1(5), GOT2(3), GPT2(4), GSS(3), NADSYN1(6), PPAT(7), QARS(4)	11630208	160	51	155	46	29	67	26	10	24	4	0.22	0.59
237	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(3), CD86(4), IFNG(5), IFNGR1(5), IFNGR2(3), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL18(1), IL18R1(5), IL2(2), IL2RA(2), IL4R(5)	4682488	61	31	60	19	13	27	5	6	10	0	0.23	0.60
238	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	60	AGTR1(1), AGTR2(7), ATP8A1(13), AVPR1A(7), AVPR1B(2), AVPR2(4), BDKRB1(2), BDKRB2(7), C3AR1(7), CCKAR(9), CCKBR(3), CCR1(3), CCR2(4), CCR3(4), CCR4(2), CCR6(5), CCR7(6), CCR8(5), CX3CR1(4), CXCR3(5), CXCR4(1), CXCR6(1), EDNRA(5), FPR1(1), FSHR(14), GALR1(2), GALR3(2), GALT(2), GHSR(7), GNB2L1(1), GNRHR(3), GPR77(1), GRPR(3), LHCGR(14), MC2R(1), MC3R(5), MC4R(3), MC5R(8), NMBR(3), NPY1R(3), NPY2R(3), NPY5R(7), NTSR1(4), NTSR2(1), OPRK1(6), OPRM1(8), OXTR(4), PPYR1(6), SSTR2(2), SSTR3(3), TACR1(5), TACR2(2), TACR3(8), TRHR(2), TSHR(7)	16819360	248	61	243	94	67	113	28	10	30	0	0.23	0.61
239	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(8), ERBB4(19), NRG2(2), NRG3(11), PRKCA(7), PSEN1(5)	3201680	52	24	51	19	10	21	9	6	6	0	0.24	0.61
240	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(5), ATM(42), BRCA1(14), CDKN1A(1), CHEK1(2), CHEK2(11), JUN(1), MAPK8(7), MDM2(3), MRE11A(9), NFKB1(7), NFKBIA(2), RAD50(15), RAD51(2), RBBP8(8), RELA(4)	10290512	133	45	130	35	23	47	23	8	26	6	0.24	0.62
241	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(3), ACP2(1), ACP5(2), ACPP(3), ACPT(5), ENPP1(8), ENPP3(14), FLAD1(4), RFK(1), TYR(8)	3529288	49	25	49	13	11	19	12	5	2	0	0.24	0.62
242	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	13	ATN1(6), CASP1(5), CASP3(3), CASP7(4), GAPDH(2), INSR(12), ITCH(7), MAGI1(20), MAGI2(23), RERE(13), WWP1(12), WWP2(4)	7892600	111	39	109	31	21	57	15	4	12	2	0.25	0.63
243	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(9), ACACA(27), ACACB(25), ACADM(4), ACAT1(4), ACAT2(4), ACSS1(3), ACSS2(7), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH6A1(3), ALDH7A1(2), ALDH9A1(1), ECHS1(2), EHHADH(4), HADHA(5), HIBCH(6), LDHA(6), LDHAL6A(7), LDHAL6B(2), LDHB(2), LDHC(4), MLYCD(3), MUT(6), PCCA(6), PCCB(7), SUCLA2(5), SUCLG1(3), SUCLG2(10)	14300424	177	54	172	48	47	63	29	13	23	2	0.25	0.63
244	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	49	AKR1C3(2), ALOX12(5), ALOX12B(8), ALOX15(7), ALOX15B(5), ALOX5(6), CBR1(1), CBR3(1), CYP2B6(11), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2E1(1), CYP2J2(2), CYP2U1(1), CYP4A11(4), CYP4A22(5), CYP4F2(8), CYP4F3(7), EPHX2(5), GGT1(5), GPX3(2), GPX5(5), GPX6(6), GPX7(1), LTA4H(4), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PTGDS(4), PTGES(2), PTGES2(2), PTGIS(6), PTGS1(5), PTGS2(6), TBXAS1(4)	13418288	177	54	173	50	49	77	25	8	18	0	0.25	0.63
245	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(8), EGF(17), EGFR(10), GRB2(3), MAP2K1(2), MAPK1(2), MAPK3(3), PTPRB(19), RAF1(5), SHC1(5), SOS1(10), SPRY1(3), SPRY2(4), SPRY4(1), SRC(2)	8372728	94	43	91	26	18	39	22	5	10	0	0.25	0.63
246	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(5), PRKCA(7), TGM2(6)	1835696	23	19	23	14	9	6	3	3	2	0	0.25	0.63
247	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(2), EIF1(1), EIF2B2(4), EIF2B3(7), EIF2B4(3), EIF2B5(4), EIF2S2(5), EIF2S3(5), ELAVL1(6), FLT1(15), FLT4(9), HIF1A(12), KDR(20), NOS3(6), PLCG1(8), PRKCA(7), PTK2(8), PXN(4), SHC1(5), VHL(2)	10091120	133	45	131	42	37	52	14	9	21	0	0.25	0.63
248	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), GOT1(5), GOT2(3), GPT2(4), MDH1(2), MDH2(4), ME1(7), ME3(6), PGK1(5), PGK2(2), PKLR(5), PKM2(4), RPE(2), RPIA(7), TKT(4), TKTL1(7), TKTL2(12)	6775112	94	38	91	32	24	40	11	6	13	0	0.25	0.63
249	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	30	ABAT(9), ADC(5), ALDH4A1(1), ALDH5A1(5), CAD(21), CPS1(19), EARS2(3), EPRS(7), GAD1(6), GAD2(10), GCLC(5), GCLM(2), GFPT1(8), GFPT2(10), GLS(9), GLS2(6), GLUD1(3), GLUD2(6), GLUL(6), GMPS(11), GNPNAT1(1), GOT1(5), GOT2(3), GPT2(4), GSR(4), GSS(3), NADSYN1(6), NAGK(1), PPAT(7), QARS(4)	13876096	190	55	185	59	38	83	27	10	28	4	0.25	0.63
250	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	39	AGL(15), AMY2A(4), AMY2B(9), ENPP1(8), ENPP3(14), G6PC(5), GAA(4), GANAB(8), GBA3(7), GBE1(4), GCK(3), GPI(5), GUSB(4), GYS1(9), GYS2(14), HK1(9), HK2(5), HK3(8), MGAM(36), PGM1(5), PGM3(4), PYGB(9), PYGL(6), PYGM(4), UCHL1(3), UCHL3(1), UGDH(2), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2B15(8), UGT2B4(7), UXS1(5)	18737144	259	67	256	75	76	85	45	16	37	0	0.26	0.63
251	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(1), B4GALT7(3), HS3ST1(4), HS3ST2(3), HS3ST3A1(2), XYLT1(10), XYLT2(3)	2161072	26	20	26	13	6	13	4	1	2	0	0.26	0.63
252	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(1), B4GALT7(3), HS3ST1(4), HS3ST2(3), HS3ST3A1(2), XYLT1(10), XYLT2(3)	2161072	26	20	26	13	6	13	4	1	2	0	0.26	0.63
253	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(11), POLR1B(10), POLR1C(2), POLR1D(1), POLR2A(17), POLR2B(14), POLR2C(3), POLR2D(2), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), POLR3A(5), POLR3B(6), POLR3G(2), POLR3GL(3), POLR3H(3)	8473168	86	38	85	27	20	32	9	9	16	0	0.26	0.63
254	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(6), PGLYRP2(5)	676792	11	9	10	7	4	3	1	0	3	0	0.26	0.63
255	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	118	ARAF(8), BID(2), BRAF(9), CASP3(3), CD244(3), CD247(3), CD48(1), FAS(6), FASLG(5), FCER1G(1), FCGR3A(1), FCGR3B(1), FYN(6), GRB2(3), GZMB(2), HCST(1), HLA-A(1), HLA-B(4), HLA-C(1), HLA-E(1), HLA-G(2), ICAM1(1), ICAM2(3), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(6), IFNAR2(6), IFNB1(2), IFNG(5), IFNGR1(5), IFNGR2(3), ITGAL(12), ITGB2(10), KIR2DL1(4), KIR2DL4(2), KIR3DL1(6), KIR3DL2(3), KLRC1(2), KLRC2(3), KLRC3(1), KLRD1(1), KLRK1(1), LCK(3), LCP2(4), MAP2K1(2), MAPK1(2), MAPK3(3), MICB(2), NCR1(5), NCR2(3), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), PAK1(1), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG1(8), PLCG2(23), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRF1(6), PRKCA(7), PRKCG(6), PTK2B(13), PTPN11(5), RAC1(1), RAC2(2), RAF1(5), SH2D1A(3), SH2D1B(2), SH3BP2(7), SHC1(5), SHC3(9), SHC4(5), SOS1(10), SOS2(16), SYK(3), TNFRSF10A(2), TNFRSF10B(4), TNFRSF10C(2), TNFRSF10D(5), ULBP1(2), ULBP2(4), VAV1(10), VAV2(3), VAV3(9), ZAP70(6)	37690048	476	92	466	156	133	183	69	29	58	4	0.26	0.63
256	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNB1(1), HTR2C(13), PLCB1(4), TUB(11)	2571016	32	23	31	10	11	11	6	3	1	0	0.27	0.64
257	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	ALDOB(6), ENO1(4), GPI(5), HK1(9), PGAM1(1), PGK1(5), PKLR(5)	2672696	35	21	34	10	10	13	3	2	7	0	0.27	0.64
258	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(3), FUCA1(2), FUCA2(3), GLB1(4), HEXA(1), HEXB(3), LCT(24), MAN2B1(11), MAN2B2(4), MAN2C1(6), MANBA(12), NEU2(4), NEU3(2)	7077176	79	39	78	28	20	34	13	5	7	0	0.27	0.64
259	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	40	IMPA1(3), IMPA2(5), INPP1(2), INPP4B(12), INPP5A(4), INPP5B(4), IPMK(4), ITPK1(2), ITPKB(7), MINPP1(1), OCRL(15), PI4KA(9), PI4KB(6), PIK3C3(9), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIP4K2A(2), PIP4K2B(7), PIP4K2C(3), PIP5K1A(6), PIP5K1B(3), PIP5K1C(4), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(3), PLCD4(10), PLCE1(31), PLCG1(8), PLCG2(23), PLCZ1(11), PTPMT1(1), SYNJ1(24), SYNJ2(8)	22655792	308	70	299	113	86	117	49	16	38	2	0.27	0.65
260	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(18), C5(14), C6(13), C7(16), C8A(9)	4060008	70	29	66	17	13	33	9	3	8	4	0.27	0.65
261	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(5), GOT2(3), TAT(5)	934216	13	11	13	2	2	5	2	4	0	0	0.28	0.65
262	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(6), ABAT(9), ACADS(4), ACAT1(4), ACAT2(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH5A1(5), ALDH9A1(1), ECHS1(2), EHHADH(4), GAD1(6), GAD2(10), HADHA(5), HMGCL(2), L2HGDH(3), OXCT1(8), PDHA1(4), PDHA2(8), PDHB(3), SDHB(1), SDS(1)	9084736	114	44	111	33	26	45	17	10	16	0	0.28	0.65
263	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	7	CCNA1(3), CDK2(2), CUL1(12), E2F1(6), SKP2(4)	2347320	27	19	27	5	2	13	6	2	4	0	0.28	0.65
264	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(4), BAD(2), BRAF(9), CREB1(5), CREB5(3), DUSP6(1), DUSP9(1), EEF2K(7), EIF4E(2), GRB2(3), MAP2K1(2), MAP3K8(6), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(3), MOS(6), NFKB1(7), RAP1A(3), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), SHC1(5), SOS1(10), SOS2(16), TRAF3(4)	10345816	137	49	133	42	33	53	23	10	16	2	0.28	0.65
265	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(3), FUCA1(2), FUCA2(3), GLB1(4), HEXA(1), HEXB(3), LCT(24), MAN2C1(6), MANBA(12), NEU2(4), NEU3(2)	5744672	64	34	63	23	16	23	13	5	7	0	0.28	0.65
266	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(9), COPS5(5), CREB1(5), EDN1(2), EP300(23), EPO(1), HIF1A(12), JUN(1), LDHA(6), NOS3(6), VHL(2)	5812624	74	31	73	11	20	22	14	4	14	0	0.28	0.65
267	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(8), PRKCA(7), PTK2B(13)	2451480	31	21	30	19	9	13	4	4	1	0	0.28	0.65
268	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	18	CCNA1(3), CCNB1(7), CCND2(7), CCND3(3), CCNH(3), CDC25A(7), CDK2(2), CDK4(3), CDK6(3), CDK7(4), CDKN1A(1), CDKN2A(1), CDKN2C(2), CDKN2D(1), E2F1(6), RBL1(13)	4639336	66	30	64	15	9	30	9	6	12	0	0.28	0.65
269	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(10), ACO2(5), AFMID(4), CS(5), GRHPR(3), HAO1(1), HAO2(7), HYI(2), MDH1(2), MDH2(4), MTHFD1(4), MTHFD1L(11), MTHFD2(2)	4881880	60	32	59	23	23	21	7	5	4	0	0.29	0.65
270	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(6), F13A1(7), F2(8), F2R(6), FGA(23), FGB(4), FGG(9), PLAT(5), PLAU(4), PLG(9), SERPINB2(6), SERPINE1(5)	4928008	92	34	88	22	32	28	20	5	7	0	0.29	0.65
271	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(4), ASL(2), CPS1(19), GLS(9), GLUD1(3), GOT1(5)	2720064	42	21	40	11	8	17	5	2	6	4	0.29	0.66
272	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(9), F2(8), F2R(6), F3(6), F5(36), F7(1), FGA(23), FGB(4), FGG(9), PROC(3), PROS1(1), SERPINC1(5), TFPI(7)	5748144	118	35	113	24	40	43	19	7	9	0	0.29	0.66
273	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(3), DLG4(10), GRIN1(3), GRIN2A(18), GRIN2B(18), GRIN2C(5), GRIN2D(5), NOS1(14), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), SYT1(4)	8881624	119	44	117	60	25	53	23	6	12	0	0.30	0.67
274	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(15), CAPN1(2), CAPNS1(1), CAPNS2(3), CDK5(1), CDK5R1(2), CSNK1A1(4), GSK3B(8), MAPT(9), PPP2CA(4)	3212592	49	24	48	14	11	25	6	1	6	0	0.30	0.67
275	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	19	CSNK2A1(7), FOS(2), GRB2(3), JAK2(14), JUN(1), MAP2K1(2), MAPK3(3), MPL(4), PLCG1(8), PRKCA(7), RAF1(5), SHC1(5), SOS1(10), STAT1(12), STAT3(8), STAT5A(2), STAT5B(3), THPO(5)	8783416	101	42	96	32	26	40	17	7	7	4	0.30	0.67
276	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(4), CYP11A1(7), CYP11B2(5), CYP17A1(1), HSD11B1(3), HSD3B1(1), HSD3B2(5)	2552664	26	20	26	12	6	10	2	1	7	0	0.30	0.67
277	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(4), ACAA2(2), ACADL(7), ACADM(4), ACADS(4), ACADSB(4), ACAT1(4), ACAT2(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH6A1(3), ALDH9A1(1), AOX1(14), BCAT1(5), BCKDHA(4), BCKDHB(2), ECHS1(2), EHHADH(4), HADHA(5), HADHB(3), HIBADH(3), HMGCL(2), MCCC1(7), MCCC2(4), MUT(6), OXCT1(8), PCCA(6), PCCB(7), SDS(1)	12613032	144	50	142	50	35	56	25	11	17	0	0.30	0.67
278	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(6), ACO1(10), ACO2(5), CLYBL(7), CS(5), DLD(3), DLST(8), FH(8), IDH1(3), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(6), MDH1(2), MDH2(4), OGDH(9), OGDHL(15), PC(9), PCK1(8), PCK2(7), SDHA(10), SDHB(1), SDHC(4), SUCLA2(5), SUCLG1(3), SUCLG2(10)	10859424	156	51	152	60	38	71	21	12	14	0	0.30	0.67
279	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(21), APOC1(1), APOE(1), CETP(4), CYP7A1(10), HMGCR(9), LCAT(2), LDLR(6), LIPC(5), LPL(9), LRP1(36), SCARB1(6), SOAT1(7)	9114496	117	47	115	30	36	50	15	6	10	0	0.30	0.67
280	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(18), DIAPH1(10), FYN(6), GSN(4), ITGA1(13), ITGB1(5), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(1), MYLK(10), PFN1(1), PTK2(8), PXN(4), RAF1(5), ROCK1(15), SHC1(5), SRC(2), TLN1(20)	12420584	134	47	134	28	38	53	17	6	16	4	0.31	0.67
281	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	55	APAF1(11), ATM(42), ATR(26), BAI1(6), BAX(3), BID(2), CASP3(3), CASP9(2), CCNB1(7), CCNB2(3), CCNB3(19), CCND2(7), CCND3(3), CCNE2(5), CCNG1(6), CCNG2(2), CD82(2), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(11), CYCS(2), DDB2(3), EI24(3), FAS(6), GTSE1(1), IGF1(2), IGFBP3(3), MDM2(3), PERP(3), PMAIP1(1), PPM1D(9), RCHY1(3), RFWD2(4), RRM2(5), RRM2B(4), SERPINE1(5), SESN1(4), SESN2(2), SIAH1(3), STEAP3(4), THBS1(9), TNFRSF10B(4), TP53I3(4), TSC2(13), ZMAT3(8)	19965488	280	65	273	87	53	110	42	19	48	8	0.31	0.67
282	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(6), IFNB1(2), JAK1(16), PTPRU(12), REG1A(2), STAT1(12), STAT2(5), TYK2(4)	4487064	59	30	58	20	12	24	10	5	8	0	0.31	0.67
283	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(3), MMP2(6), MMP9(11), RECK(13), TIMP1(3), TIMP2(1), TIMP3(8), TIMP4(1)	2711136	46	24	45	17	15	18	7	1	5	0	0.31	0.68
284	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(5), BCAT2(3), COASY(10), DPYD(11), DPYS(3), ENPP1(8), ENPP3(14), ILVBL(7), PANK1(2), PANK2(7), PANK3(4), PANK4(3), PPCDC(1), PPCS(4), UPB1(8), VNN1(6)	5983248	96	35	94	21	28	34	17	6	11	0	0.31	0.68
285	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	DPM2(2), EGFR(10), ELK1(2), GNAS(16), GNB1(1), GRB2(3), IGF1R(10), ITGB1(5), KLK2(2), MAP2K1(2), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(3), MYC(6), NGFR(3), PDGFRA(19), PPP2CA(4), PTPRR(13), RAF1(5), RPS6KA1(1), RPS6KA5(7), SHC1(5), SOS1(10), SRC(2), STAT3(8)	11406016	147	50	142	32	35	63	23	9	15	2	0.32	0.68
286	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(9), ACACA(27), ACADL(7), ACADM(4), ACADSB(4), ACAT1(4), ACAT2(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH6A1(3), ALDH9A1(1), ECHS1(2), EHHADH(4), HADHA(5), LDHA(6), LDHB(2), LDHC(4), MLYCD(3), MUT(6), PCCA(6), PCCB(7), SDS(1), SUCLA2(5), SUCLG1(3), SUCLG2(10)	11894824	151	49	149	46	36	51	28	13	23	0	0.32	0.68
287	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(5), CS(5), DLAT(1), DLD(3), DLST(8), FH(8), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(6), MDH1(2), MDH2(4), OGDH(9), PC(9), PDHA1(4), PDHA2(8), PDHB(3), PDHX(7), PDK1(2), PDK2(3), PDK3(10), PDK4(7), PDP2(4), SDHA(10), SDHB(1), SDHC(4), SUCLA2(5), SUCLG1(3), SUCLG2(10)	10220576	149	47	147	51	37	66	18	10	18	0	0.32	0.69
288	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	12	NDUFA1(1), NDUFA10(6), NDUFA4(1), NDUFA5(4), NDUFA8(5), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(2)	2343848	35	21	34	8	11	17	2	2	3	0	0.33	0.69
289	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	66	ACACB(25), ACSL1(9), ACSL3(6), ACSL5(8), ACSL6(9), ADIPOQ(2), ADIPOR2(7), AGRP(2), AKT1(3), AKT2(4), AKT3(7), CAMKK1(9), CAMKK2(6), CD36(5), CHUK(7), CPT1A(6), CPT1B(1), CPT1C(11), CPT2(4), G6PC(5), G6PC2(4), IKBKB(8), IRS1(10), IRS4(16), JAK1(16), JAK2(14), JAK3(5), LEP(1), LEPR(10), MAPK10(7), MAPK8(7), MAPK9(4), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NPY(2), PCK1(8), PCK2(7), POMC(1), PPARGC1A(8), PRKAA1(5), PRKAA2(7), PRKAB1(6), PRKAB2(1), PRKAG1(2), PRKAG2(3), PRKAG3(5), PRKCQ(6), PTPN11(5), RELA(4), RXRA(1), RXRG(6), SLC2A1(2), SLC2A4(5), STAT3(8), TNFRSF1A(4), TNFRSF1B(1), TRAF2(2), TYK2(4)	28590928	364	82	357	130	70	165	59	15	47	8	0.33	0.69
290	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	16	CALM2(3), CCL4(1), CXCL12(2), CXCR4(1), FOS(2), JUN(1), MAPK14(4), MAPK8(7), PLCG1(8), PRKCA(7), PTK2B(13), SYT1(4)	4736304	53	29	52	25	16	17	7	6	7	0	0.33	0.69
291	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(5), ACTB(3), ACTG1(1), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(4), CDH1(12), CLDN1(2), CTTN(4), EZR(4), FYN(6), HCLS1(8), ITGB1(5), LY96(3), NCK1(4), NCK2(7), NCL(3), OCLN(2), PRKCA(7), RHOA(3), ROCK1(15), ROCK2(10), TLR4(13), TLR5(6), TUBA1A(6), TUBA1B(1), TUBA1C(5), TUBA3C(3), TUBA3D(2), TUBA3E(10), TUBA4A(7), TUBA8(7), TUBAL3(3), TUBB1(5), TUBB2A(2), TUBB2B(1), TUBB6(4), TUBB8(3), WAS(8), WASL(7), YWHAQ(1), YWHAZ(1)	18751032	214	65	213	62	54	95	21	10	32	2	0.33	0.69
292	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(5), ACTB(3), ACTG1(1), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(4), CDH1(12), CLDN1(2), CTTN(4), EZR(4), FYN(6), HCLS1(8), ITGB1(5), LY96(3), NCK1(4), NCK2(7), NCL(3), OCLN(2), PRKCA(7), RHOA(3), ROCK1(15), ROCK2(10), TLR4(13), TLR5(6), TUBA1A(6), TUBA1B(1), TUBA1C(5), TUBA3C(3), TUBA3D(2), TUBA3E(10), TUBA4A(7), TUBA8(7), TUBAL3(3), TUBB1(5), TUBB2A(2), TUBB2B(1), TUBB6(4), TUBB8(3), WAS(8), WASL(7), YWHAQ(1), YWHAZ(1)	18751032	214	65	213	62	54	95	21	10	32	2	0.33	0.69
293	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(10), ACO2(5), FH(8), IDH1(3), IDH2(4), MDH1(2), MDH2(4), SDHB(1), SUCLA2(5)	3250536	42	26	42	23	12	18	3	5	4	0	0.33	0.69
294	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	20	ARSB(4), ARSD(6), ARSE(5), ASAH1(6), GAL3ST1(7), GALC(3), GBA(3), GLA(2), GLB1(4), LCT(24), NEU2(4), NEU3(2), PPAP2A(4), PPAP2B(2), SMPD1(10), SMPD2(4), SPTLC1(5), SPTLC2(4), UGCG(4)	8156720	103	40	102	31	26	51	7	8	11	0	0.33	0.69
295	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(3), ACP2(1), ACP5(2), ACP6(3), ACPP(3), ACPT(5), ENPP1(8), ENPP3(14), FLAD1(4), LHPP(2), MTMR1(13), MTMR2(2), MTMR6(7), PHPT1(1), RFK(1), TYR(8)	5416816	77	31	76	22	15	28	17	5	12	0	0.33	0.70
296	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(8), AGT(7), AGTR2(7), EDN1(2), EDNRA(5), EGF(17), EGFR(10), FOS(2), JUN(1), MYC(6), NFKB1(7), PLCG1(8), PRKCA(7), RELA(4)	7517376	91	39	87	35	18	43	16	7	7	0	0.34	0.70
297	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(4), CYB5R3(5), GCK(3), GFPT1(8), GNE(8), GNPDA1(1), GNPDA2(6), HEXA(1), HEXB(3), HK1(9), HK2(5), HK3(8), PGM3(4), RENBP(3), UAP1(5)	6044752	73	35	72	30	18	24	14	7	10	0	0.34	0.71
298	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	20	ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), GOT1(5), GOT2(3), GPT2(4), MDH1(2), MDH2(4), ME1(7), ME2(5), ME3(6), PGK1(5), PKLR(5), PKM2(4), RPE(2), RPIA(7), TKT(4)	6047728	78	34	76	26	20	32	12	5	9	0	0.34	0.71
299	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(1), CDC7(10), CDK2(2), DIAPH2(18), GMNN(2), MCM10(5), MCM2(4), MCM3(8), MCM4(6), MCM5(7), MCM6(4), MCM7(3), NACA(17), PCNA(2), POLA2(1), POLD1(11), POLD2(5), POLD3(4), POLD4(1), POLE2(2), PRIM1(2), RFC1(13), RFC2(3), RFC3(4), RFC4(3), RFC5(7), RPA1(5), RPA2(2), RPA3(3), RPA4(4), RPS27A(3), UBB(1), UBC(7)	17802184	170	58	163	42	58	65	17	7	23	0	0.34	0.71
300	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	19	ADCY1(12), AKT1(3), ASAH1(6), GNAI1(4), GNB1(1), ITGAV(6), ITGB3(10), MAPK1(2), MAPK3(3), PDGFRA(19), PLCB1(4), PRKCA(7), PTK2(8), RAC1(1), SMPD1(10), SMPD2(4), SPHK1(2), SRC(2)	8318416	104	40	102	39	16	46	17	8	15	2	0.35	0.71
301	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	30	APAF1(11), BID(2), BIRC2(10), BIRC3(2), CASP10(8), CASP3(3), CASP6(3), CASP7(4), CASP9(2), CFLAR(5), CHUK(7), CYCS(2), DFFB(3), GAS2(6), LMNA(5), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(8), SPTAN1(23), TNFRSF10A(2), TNFRSF10B(4), TNFRSF25(1), TNFSF12(4), TRAF2(2)	11278544	134	47	131	35	38	49	16	4	27	0	0.35	0.71
302	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(9), ACAA1(4), ACAA2(2), ACADM(4), ACADS(4), ACAT1(4), ACAT2(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH6A1(3), ALDH7A1(2), ALDH9A1(1), AOX1(14), AUH(3), BCAT1(5), BCAT2(3), BCKDHA(4), BCKDHB(2), DBT(3), DLD(3), ECHS1(2), EHHADH(4), HADH(1), HADHA(5), HADHB(3), HIBADH(3), HIBCH(6), HMGCL(2), HMGCS1(3), HMGCS2(6), HSD17B10(2), HSD17B4(8), MCCC1(7), MCCC2(4), MUT(6), OXCT1(8), OXCT2(2), PCCA(6), PCCB(7)	15176856	169	54	166	49	42	68	32	11	16	0	0.35	0.71
303	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(8), DLL1(6), FURIN(4), PSEN1(5)	1817592	23	16	23	11	3	14	1	1	4	0	0.35	0.71
304	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(4), ICAM1(1), ITGA4(8), ITGAL(12), ITGB1(5), ITGB2(10), SELE(5), SELL(3)	4849640	48	29	48	22	15	16	7	4	6	0	0.36	0.72
305	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	35	ACTA1(3), ACTA2(5), ACTN2(7), ACTN3(6), ACTN4(6), DES(5), DMD(67), FAM48A(3), MYBPC1(13), MYBPC2(5), MYBPC3(10), MYH3(20), MYH6(12), MYH7(26), MYH8(25), MYL1(5), MYL2(1), MYL9(3), MYOM1(29), NEB(101), TMOD1(2), TNNC2(3), TNNI1(1), TNNI3(2), TNNT1(3), TNNT2(6), TPM1(2), TPM3(4), TPM4(3), TTN(439), VIM(7)	50949616	824	103	795	231	231	301	125	48	51	68	0.36	0.72
306	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	B2M(2), CALR(1), CANX(4), CD4(6), CD8A(2), CD8B(1), CIITA(12), CREB1(5), CTSL1(4), CTSS(4), HLA-A(1), HLA-B(4), HLA-C(1), HLA-DMA(3), HLA-DOA(2), HLA-DOB(2), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRB5(2), HLA-E(1), HLA-F(2), HLA-G(2), HSP90AA1(6), HSP90AB1(17), HSPA5(3), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), KIR2DL1(4), KIR2DL4(2), KIR2DS4(5), KIR3DL1(6), KIR3DL2(3), KIR3DL3(2), KLRC1(2), KLRC2(3), KLRC3(1), KLRC4(2), KLRD1(1), LGMN(4), LTA(2), NFYA(6), NFYB(2), NFYC(1), PDIA3(3), PSME1(1), PSME2(1), RFX5(6), RFXANK(3), RFXAP(2), TAP1(6), TAPBP(4)	17171024	184	56	179	48	42	86	21	8	27	0	0.36	0.73
307	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(27), CPT1A(6), LEP(1), LEPR(10), PRKAA1(5), PRKAA2(7), PRKAB1(6), PRKAB2(1), PRKAG1(2), PRKAG2(3)	5292568	68	31	67	20	20	26	8	3	11	0	0.36	0.73
308	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(3), BAD(2), CASP9(2), CHUK(7), GH1(2), GHR(8), NFKB1(7), NFKBIA(2), PDPK1(2), PPP2CA(4), RELA(4), YWHAH(2)	3823416	45	25	45	7	9	18	9	4	5	0	0.37	0.73
309	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(9), ABP1(5), ACADL(7), ACADM(4), ACADSB(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), AOC2(6), AOC3(9), CNDP1(4), DPYD(11), DPYS(3), ECHS1(2), EHHADH(4), GAD1(6), GAD2(10), HADHA(5), MLYCD(3), SDS(1), SMS(7), UPB1(8)	10426168	133	47	130	51	39	39	23	13	19	0	0.37	0.74
310	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(5), AKR1D1(7), ARSB(4), ARSD(6), ARSE(5), CYP11B1(4), CYP11B2(5), HSD11B1(3), HSD17B2(2), HSD17B3(5), HSD17B8(2), HSD3B1(1), HSD3B2(5), SRD5A1(4), SRD5A2(5), STS(6), SULT1E1(9), SULT2A1(6), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2B15(8), UGT2B4(7)	9646456	133	44	126	40	40	50	15	13	15	0	0.37	0.74
311	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM2(3), CAMK1(2), CAMK1G(3), ELK1(2), FPR1(1), GNA15(1), GNB1(1), MAP2K1(2), MAP2K3(7), MAP2K6(6), MAP3K1(24), MAPK1(2), MAPK14(4), MAPK3(3), NCF1(3), NCF2(4), NFATC2(9), NFATC3(9), NFATC4(7), NFKB1(7), NFKBIA(2), PAK1(1), PIK3C2G(12), PLCB1(4), PPP3CA(2), PPP3CB(5), PPP3CC(4), RAC1(1), RAF1(5), RELA(4), SYT1(4)	13463424	144	52	142	39	38	44	25	10	25	2	0.37	0.74
312	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(5), CA1(2), CA13(1), CA14(3), CA2(2), CA3(3), CA4(1), CA5A(5), CA5B(5), CA6(2), CA7(4), CA8(5), CA9(4), CPS1(19), CTH(4), GLS(9), GLS2(6), GLUD1(3), GLUD2(6), GLUL(6), HAL(4)	7629968	101	38	96	34	35	34	11	2	15	4	0.38	0.74
313	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), HMOX1(3), IL10(2), IL10RA(3), IL10RB(6), IL6(4), JAK1(16), STAT1(12), STAT3(8), STAT5A(2)	4429776	57	28	56	22	11	27	7	2	10	0	0.38	0.74
314	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(7), CDC25A(7), CDC25B(2), CDC25C(5), CSK(1), GRB2(3), PRKCA(7), PTPRA(7), SRC(2)	3332376	41	25	40	18	8	11	10	4	8	0	0.38	0.74
315	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(3), CD3E(1), CD3G(1)	423088	5	5	5	1	0	2	1	0	2	0	0.38	0.74
316	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(4), ACAT2(4), HMGCL(2), OXCT1(8)	1210736	18	14	18	2	5	9	1	0	3	0	0.38	0.75
317	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(12), CALM2(3), CREB1(5), ELK1(2), FOS(2), GNAI1(4), GNAS(16), GNB1(1), JUN(1), MAP2K1(2), MAPK3(3), NFATC2(9), NFATC3(9), NFATC4(7), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), RAF1(5), RPS6KA3(15), SYT1(4)	11877216	147	48	141	42	42	51	20	11	23	0	0.38	0.75
318	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	10	ALAD(3), ALAS1(5), ALAS2(10), CPO(1), FECH(4), GATA1(5), HBB(2), HMBS(5), UROD(1), UROS(3)	2925656	39	21	38	13	6	20	6	2	5	0	0.39	0.75
319	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(3), ACP2(1), ACP5(2), ACPP(3), ACPT(5), ALPI(2), ALPL(3), ALPP(3), ALPPL2(2), CYP19A1(13), CYP1A1(9), CYP1A2(5), CYP2A13(6), CYP2A6(10), CYP2A7(4), CYP2B6(11), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2D6(1), CYP2E1(1), CYP2F1(3), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(6), CYP4B1(2), CYP4F8(6), CYP51A1(3), PON1(11)	10547688	147	45	145	51	45	52	23	9	16	2	0.39	0.75
320	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(4), ICAM1(1), ITGA4(8), ITGAL(12), ITGAM(19), ITGB1(5), ITGB2(10), SELE(5), SELL(3), SELP(10)	6316312	77	35	74	26	22	30	8	4	11	2	0.39	0.76
321	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(7), DUSP1(2), IKBKAP(8), IKBKB(8), MAP3K1(24), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(4), TNFAIP3(2), TRAF3(4), TRAF6(3)	6570760	75	33	74	21	17	28	9	7	12	2	0.40	0.76
322	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	21	ATM(42), BMPR1B(6), CCND2(7), CDK4(3), DAZL(5), DMC1(4), EGR1(6), ESR2(4), FSHR(14), GJA4(1), INHA(1), LHCGR(14), MLH1(7), MSH5(7), NCOR1(16), NRIP1(14), PRLR(3), PTGER2(2), SMPD1(10), VDR(7), ZP2(11)	11984104	184	47	178	48	42	71	26	4	35	6	0.40	0.76
323	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(3), DCN(7), FMOD(2), KERA(8), LUM(11)	1357552	31	16	28	10	10	12	3	1	5	0	0.40	0.76
324	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), ARG1(4), GLS(9), GLUD1(3), OAT(6)	1703760	23	16	21	8	2	11	5	1	4	0	0.40	0.77
325	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(5), ACTR3(1), ARHGAP1(2), ARHGAP4(8), ARHGAP5(18), ARHGAP6(11), ARHGEF1(9), ARHGEF11(18), ARHGEF5(4), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), CFL1(1), DIAPH1(10), GSN(4), LIMK1(6), MYL2(1), MYLK(10), OPHN1(10), PFN1(1), PIP5K1A(6), PIP5K1B(3), PPP1R12B(11), ROCK1(15), SRC(2), TLN1(20), VCL(8)	16659400	194	57	191	66	67	71	22	14	16	4	0.41	0.77
326	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	11	CCNA1(3), CCNA2(2), CCNE2(5), CDK2(2), CDK4(3), CDKN2A(1), E2F1(6), E2F2(2), E2F4(2), PRB1(2)	2717088	28	20	28	9	2	10	8	4	4	0	0.41	0.77
327	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ADRBK2(11), ARRB2(3), CALM2(3), CALML6(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CLCA1(13), CLCA2(8), CLCA4(10), CNGA3(10), CNGA4(6), CNGB1(9), GNAL(6), GUCA1A(5), GUCA1B(3), GUCA1C(3), PDE1C(10), PRKACA(4), PRKACG(7), PRKG1(4), PRKG2(8), PRKX(2)	10849752	147	48	144	60	41	59	17	6	24	0	0.41	0.77
328	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(6), CYSLTR2(3), GPR161(3), GPR171(5), GPR18(1), GPR34(6), GPR39(8), GPR45(2), GPR65(8), GPR68(3), GPR75(8)	3622536	53	25	50	23	10	20	16	3	4	0	0.41	0.78
329	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(9), ABP1(5), ACADM(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AOC2(6), AOC3(9), CNDP1(4), DPYD(11), DPYS(3), ECHS1(2), EHHADH(4), GAD1(6), GAD2(10), HADHA(5), HIBCH(6), MLYCD(3), SMS(7), SRM(1), UPB1(8)	9586936	116	43	113	38	36	34	20	11	15	0	0.41	0.78
330	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	76	ACVR1(9), ACVR1B(5), ACVRL1(1), AKT1(3), AURKB(3), BMPR1A(4), BMPR2(9), BUB1(7), CDKL1(6), CDKL2(5), CDS1(4), CLK1(7), CLK2(7), CLK4(5), CSNK2A1(7), CSNK2A2(3), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKZ(8), IMPA1(3), INPP1(2), INPP4B(12), INPP5A(4), ITPKB(7), MAP3K10(6), MOS(6), NEK1(17), NEK3(6), OCRL(15), PIK3C2A(14), PIK3C2B(10), PIK3C2G(12), PIK3CB(13), PIK3CG(18), PIM2(3), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCG1(8), PLCG2(23), PLK3(7), PRKACA(4), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(7), PRKCG(6), PRKCH(7), PRKCQ(6), PRKCZ(3), PRKD1(6), PRKG1(4), RAF1(5), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA4(1), RPS6KB1(2), TGFBR1(3), VRK1(10)	37777592	502	88	487	174	142	184	73	31	70	2	0.42	0.78
331	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(16), JAK2(14), JAK3(5), PIAS1(3), PIAS3(7), PTPRU(12), REG1A(2), SOAT1(7)	5002904	67	29	66	18	13	28	9	3	10	4	0.42	0.78
332	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	15	DNAJA3(4), IFNG(5), IFNGR1(5), IFNGR2(3), IKBKB(8), JAK2(14), LIN7A(6), NFKB1(7), NFKBIA(2), RELA(4), TNFRSF1A(4), TNFRSF1B(1), USH1C(9), WT1(2)	5428472	74	32	74	29	13	26	16	3	12	4	0.42	0.78
333	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	89	ANK2(26), B3GALT4(3), CDR1(2), DGKI(16), FAU(1), IL6ST(6), MRPL19(5), PIGK(6), RPL10(4), RPL11(1), RPL15(1), RPL17(5), RPL18(4), RPL18A(2), RPL19(2), RPL21(2), RPL22(3), RPL23(1), RPL24(2), RPL27(1), RPL27A(3), RPL28(2), RPL29(2), RPL3(1), RPL35A(2), RPL37(3), RPL38(1), RPL39(3), RPL3L(3), RPL4(3), RPL5(5), RPL6(2), RPL8(1), RPL9(1), RPLP0(4), RPS10(1), RPS12(2), RPS13(1), RPS18(3), RPS20(3), RPS21(1), RPS24(2), RPS25(1), RPS27(1), RPS27A(3), RPS29(2), RPS3(2), RPS3A(1), RPS4X(1), RPS6(6), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KA6(12), RPS6KB1(2), RPS6KB2(4), RPS7(3), RPS8(2), RPS9(1), SLC36A2(5), TBC1D10C(1), TSPAN9(3), UBB(1), UBC(7)	18406560	230	61	221	85	62	86	35	14	33	0	0.42	0.78
334	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(5), COASY(10), DPYD(11), DPYS(3), ENPP1(8), ENPP3(14), PANK1(2), PANK2(7), PANK3(4), PANK4(3), PPCS(4), UPB1(8)	4731344	79	29	78	13	24	25	14	5	11	0	0.42	0.78
335	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(5), CA1(2), CA14(3), CA2(2), CA3(3), CA4(1), CA5A(5), CA5B(5), CA6(2), CA7(4), CA8(5), CA9(4), CPS1(19), CTH(4), GLS(9), GLS2(6), GLUD1(3), GLUL(6), HAL(4)	6862160	94	36	89	26	33	30	10	2	15	4	0.42	0.78
336	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(4), ALDOB(6), ALDOC(3), DLAT(1), DLD(3), ENO1(4), ENO2(3), ENO3(3), FBP1(2), G6PC(5), GAPDH(2), GAPDHS(8), GCK(3), GOT1(5), GOT2(3), GPI(5), HK1(9), HK2(5), HK3(8), LDHA(6), LDHAL6B(2), LDHB(2), LDHC(4), MDH1(2), MDH2(4), PC(9), PCK1(8), PDHA1(4), PDHA2(8), PDHB(3), PDHX(7), PFKM(4), PFKP(6), PGAM1(1), PGAM2(1), PGK1(5), PGK2(2), PKLR(5), PKM2(4), TNFAIP1(1)	14394664	170	53	168	62	49	66	20	13	22	0	0.43	0.78
337	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(27), ACACB(25), ACAT1(4), ACAT2(4), ACOT12(9), ACSS1(3), ACSS2(7), ACYP1(2), AKR1B1(1), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), DLAT(1), DLD(3), GRHPR(3), LDHA(6), LDHAL6A(7), LDHAL6B(2), LDHB(2), LDHC(4), LDHD(1), MDH1(2), MDH2(4), ME1(7), ME2(5), ME3(6), PC(9), PCK1(8), PCK2(7), PDHA1(4), PDHA2(8), PDHB(3), PKLR(5), PKM2(4)	16478856	196	59	189	70	55	76	22	9	32	2	0.43	0.78
338	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(1), ACTR2(5), ACTR3(1), AKT1(3), ANGPTL2(4), CDC42(4), CFL1(1), CFL2(7), FLNA(27), FLNC(27), FSCN1(2), FSCN3(4), GDI1(4), GDI2(1), LIMK1(6), MYH2(31), MYLK(10), MYLK2(6), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PFN1(1), PFN2(1), RHO(3), ROCK1(15), ROCK2(10), RPS4X(1), VASP(1), WASF1(3), WASL(7)	16606328	211	59	209	62	66	84	21	9	29	2	0.43	0.78
339	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(3), CAMK1(2), CAMK1G(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), ESRRA(2), HDAC5(10), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), PPP3CA(2), PPP3CB(5), PPP3CC(4), SLC2A4(5), SYT1(4), YWHAH(2)	7029312	76	34	76	28	16	34	11	2	13	0	0.43	0.78
340	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(6), ACO1(10), ACO2(5), ACSS1(3), ACSS2(7), FH(8), IDH1(3), IDH2(4), MDH1(2), MDH2(4), SUCLA2(5)	4867744	57	30	56	29	16	22	4	7	8	0	0.43	0.78
341	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	80	CD36(5), CD44(4), CD47(5), CHAD(1), COL11A1(22), COL11A2(6), COL1A1(7), COL1A2(15), COL2A1(10), COL3A1(12), COL4A1(15), COL4A2(5), COL4A4(17), COL4A6(28), COL5A2(17), COL5A3(17), COL6A3(34), COL6A6(20), DAG1(4), FN1(31), FNDC1(20), FNDC3A(6), FNDC4(1), FNDC5(1), GP1BA(9), GP5(2), GP6(2), HMMR(12), HSPG2(16), IBSP(5), ITGA1(13), ITGA10(7), ITGA11(6), ITGA2(14), ITGA2B(7), ITGA3(6), ITGA4(8), ITGA5(9), ITGA6(10), ITGA7(8), ITGA8(14), ITGA9(13), ITGAV(6), ITGB1(5), ITGB3(10), ITGB4(6), ITGB5(4), ITGB6(4), ITGB7(4), ITGB8(4), LAMA1(27), LAMA2(52), LAMA3(22), LAMA4(13), LAMB1(21), LAMB2(20), LAMB3(12), LAMB4(22), LAMC1(13), LAMC2(11), LAMC3(10), RELN(36), SDC1(1), SDC2(1), SDC3(1), SDC4(3), SPP1(2), SV2A(10), SV2B(10), SV2C(9), THBS1(9), THBS3(2), THBS4(6), TNC(14), TNN(11), TNR(11), TNXB(16), VWF(19)	75659344	891	117	875	305	231	363	115	52	108	22	0.43	0.78
342	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(3), MAX(4), MYC(6), SP1(6), SP3(8), WT1(2)	2199512	29	19	28	8	5	15	4	1	2	2	0.43	0.78
343	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	21	APC(36), ASAH1(6), CASP3(3), CERK(6), CREB1(5), CREB5(3), CXCL2(2), DAG1(4), EPHB2(8), FOS(2), ITPKB(7), JUN(1), MAP2K4(4), MAPK1(2), MAPK10(7), MAPK8(7), MAPK8IP1(4), MAPK9(4)	8730096	111	39	110	36	29	40	8	6	22	6	0.44	0.78
344	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(2), IFNG(5), IL10(2), IL12A(5), IL12B(2), IL15(1), IL16(12), IL18(1), IL2(2), IL5(1), IL6(4), IL8(3), LTA(2)	3729672	42	25	41	13	9	19	6	2	6	0	0.44	0.78
345	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	5	CDK2(2), CUL1(12), E2F1(6)	1634568	20	15	20	4	2	11	4	2	1	0	0.44	0.79
346	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), BCKDK(6), CBS(9), CTH(4), MUT(6)	1639032	27	17	26	5	8	12	3	1	3	0	0.44	0.79
347	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	47	ACHE(3), AGPAT2(1), AGPAT3(4), AGPAT4(3), AGPS(9), CDS1(4), CHAT(1), CHKA(7), CPT1B(1), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKZ(8), ETNK1(8), GNPAT(6), GPD1(2), GPD2(3), LCAT(2), LGALS13(1), LYPLA1(1), LYPLA2(4), PAFAH1B1(1), PAFAH2(2), PCYT1A(1), PCYT1B(3), PEMT(1), PISD(2), PLA2G2E(3), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCB2(7), PLCG1(8), PLCG2(23), PPAP2A(4), PPAP2B(2)	16781416	200	59	198	63	57	77	29	14	21	2	0.44	0.79
348	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(3), B4GALNT1(4), GLB1(4), HEXA(1), HEXB(3), LCT(24), SLC33A1(6), ST3GAL1(1), ST3GAL2(3), ST3GAL5(2), ST6GALNAC3(7), ST6GALNAC4(3), ST6GALNAC5(2), ST6GALNAC6(4), ST8SIA1(1), ST8SIA5(5)	5898432	73	32	71	29	22	29	7	6	9	0	0.45	0.79
349	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(7), ACTN2(7), ACTN3(6), CAPN1(2), CAPNS1(1), CAPNS2(3), ITGA1(13), ITGB1(5), ITGB3(10), PTK2(8), PXN(4), RAC1(1), SPTAN1(23), SRC(2), TLN1(20)	10313080	115	45	114	49	43	42	11	4	15	0	0.45	0.79
350	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(31), RANGAP1(3)	2990880	35	21	35	5	8	11	7	2	7	0	0.45	0.79
351	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	10	CDK2(2), CUL1(12), E2F1(6), RBX1(1), SKP2(4)	2291768	25	17	25	5	2	14	5	2	2	0	0.45	0.79
352	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(6), AANAT(2), ABP1(5), ACAT1(4), ACAT2(4), ACMSD(8), AFMID(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AOC2(6), AOC3(9), AOX1(14), ASMT(3), CARM1(4), CAT(3), CYP1A1(9), CYP1A2(5), CYP1B1(1), DDC(9), ECHS1(2), EHHADH(4), GCDH(5), HAAO(2), HADH(1), HADHA(5), HEMK1(1), HSD17B10(2), HSD17B4(8), INMT(2), KMO(7), KYNU(3), LCMT1(2), LCMT2(8), LNX1(7), MAOA(10), MAOB(5), METTL2B(3), METTL6(3), NFX1(8), OGDH(9), OGDHL(15), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), TDO2(2), TPH1(9), TPH2(4), WARS(5), WARS2(2), WBSCR22(5)	21709920	276	66	266	77	66	112	41	21	34	2	0.45	0.79
353	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(9), FOS(2), GRB2(3), IL3RA(8), JAK2(14), MAP2K1(2), MAPK3(3), RAF1(5), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3)	6209176	66	32	64	18	16	28	10	5	3	4	0.46	0.79
354	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(7), PARK2(5), SNCA(2), SNCAIP(8), UBE2E2(2), UBE2F(1), UBE2G1(2), UBE2L3(2), UBE2L6(1)	2247376	30	19	30	11	9	12	3	4	2	0	0.46	0.80
355	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	52	ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AGK(4), AGPAT2(1), AGPAT3(4), AGPAT4(3), AGPAT6(6), AKR1A1(1), AKR1B1(1), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CEL(5), DAK(4), DGAT2(4), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKI(16), DGKZ(8), GK(13), GK2(18), GLA(2), GLB1(4), GPAM(6), LCT(24), LIPA(5), LIPC(5), LIPF(6), LIPG(4), LPL(9), MGLL(2), PNLIP(2), PNLIPRP1(3), PNLIPRP2(8), PNPLA3(6), PPAP2A(4), PPAP2B(2)	20289624	281	64	275	79	80	111	39	22	29	0	0.46	0.80
356	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GBA3(7), GGT1(5), SHMT1(4), SHMT2(2)	1543304	19	15	19	4	4	9	2	0	4	0	0.46	0.80
357	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	25	BAG4(3), BIRC2(10), BIRC3(2), CASP3(3), CFLAR(5), JUN(1), MAP2K4(4), MAP3K3(6), MAP3K7(8), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), NR2C2(5), RALBP1(4), RIPK1(8), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(2)	8885592	93	40	92	23	19	41	15	4	14	0	0.46	0.80
358	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4)	2091384	32	19	32	5	9	10	8	0	5	0	0.47	0.80
359	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHA4(14), EPHB1(19), FYN(6), ITGA1(13), ITGB1(5), L1CAM(13), LYN(6), RAP1B(2), SELP(10)	5883056	91	33	89	28	22	44	10	4	11	0	0.47	0.80
360	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(3), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), HSD3B7(3), PON1(11), PON2(6), PON3(1), RDH11(1), RDH12(3), RDH13(4), RDH14(2)	3188536	48	26	46	8	15	16	9	2	6	0	0.47	0.80
361	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(6), AADAC(4), ABAT(9), ACADS(4), ACAT1(4), ACAT2(4), ACSM1(8), AKR1B10(3), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH5A1(5), ALDH7A1(2), ALDH9A1(1), BDH1(3), BDH2(4), DDHD1(10), ECHS1(2), EHHADH(4), GAD1(6), GAD2(10), HADH(1), HADHA(5), HMGCL(2), HMGCS1(3), HMGCS2(6), HSD17B10(2), HSD17B4(8), HSD3B7(3), ILVBL(7), L2HGDH(3), OXCT1(8), OXCT2(2), PDHA1(4), PDHA2(8), PDHB(3), PLA1A(3), PPME1(1), PRDX6(2), RDH11(1), RDH12(3), RDH13(4), RDH14(2)	14378792	180	52	173	48	45	72	26	15	20	2	0.47	0.80
362	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	60	AKT1(3), AKT2(4), AKT3(7), BAD(2), CASP9(2), CDC42(4), KDR(20), MAP2K1(2), MAPK1(2), MAPK13(2), MAPK14(4), MAPK3(3), MAPKAPK2(4), MAPKAPK3(2), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NOS3(6), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLCG1(8), PLCG2(23), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKCA(7), PRKCG(6), PTGS2(6), PTK2(8), PXN(4), RAC1(1), RAC2(2), RAF1(5), SPHK1(2), SPHK2(1), SRC(2)	21928408	277	68	273	93	77	108	36	19	37	0	0.47	0.80
363	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(5), ALDH3A1(2), ALDH3B2(5), AOC2(6), AOC3(9), DDC(9), EPX(11), ESCO1(8), ESCO2(5), GOT1(5), GOT2(3), HPD(7), LPO(4), MAOA(10), MAOB(5), MPO(6), NAT6(1), PNPLA3(6), PRDX6(2), SH3GLB1(6), TAT(5), TPO(11)	12331800	131	46	125	47	35	43	21	9	23	0	0.47	0.80
364	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(6), ALDH1A2(8), BCMO1(2), RDH5(3)	1415336	19	13	19	11	7	6	1	1	4	0	0.48	0.80
365	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(7), ELK1(2), EPO(1), EPOR(3), FOS(2), GRB2(3), JAK2(14), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(7), PLCG1(8), RAF1(5), SHC1(5), SOS1(10), STAT5A(2), STAT5B(3)	7731648	78	36	74	18	22	27	13	6	6	4	0.48	0.80
366	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(6), IFNAR2(6), IFNB1(2), JAK1(16), STAT1(12), STAT2(5), TYK2(4)	3963784	51	25	49	18	11	16	11	5	8	0	0.48	0.80
367	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	62	ADAM10(3), ADAM17(8), ATP6AP1(6), ATP6V0A1(5), ATP6V0A2(10), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(7), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(5), ATP6V1C1(3), ATP6V1D(2), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), CASP3(3), CCL5(2), CDC42(4), CHUK(7), CSK(1), CXCL1(1), EGFR(10), F11R(1), GIT1(8), HBEGF(2), IGSF5(6), IKBKB(8), IL8(3), JAM2(7), JAM3(2), JUN(1), LYN(6), MAP2K4(4), MAP3K14(4), MAPK10(7), MAPK13(2), MAPK14(4), MAPK8(7), MAPK9(4), MET(9), NFKB1(7), NFKB2(9), NFKBIA(2), NOD1(7), PAK1(1), PLCG1(8), PLCG2(23), PTPN11(5), PTPRZ1(35), RAC1(1), RELA(4), SRC(2), TCIRG1(5), TJP1(18)	24458008	340	70	334	107	78	152	43	16	49	2	0.48	0.80
368	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CD3D(3), CD3E(1), CD3G(1), CXCR3(5), ETV5(3), IFNG(5), IL12A(5), IL12B(2), IL12RB1(11), IL12RB2(8), IL18(1), IL18R1(5), JAK2(14), JUN(1), MAP2K6(6), MAPK14(4), MAPK8(7), STAT4(6), TYK2(4)	6621848	92	34	91	25	16	28	16	12	16	4	0.48	0.80
369	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	16	ACY1(3), ALDH18A1(9), ARG1(4), ARG2(3), ASL(2), CKM(2), CKMT1A(1), CKMT2(2), CPS1(19), GATM(4), GLUD1(3), OAT(6), ODC1(1), OTC(6), SMS(7)	5584216	72	31	70	25	18	31	9	3	7	4	0.48	0.80
370	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(5), AKR1D1(7), ARSD(6), ARSE(5), CARM1(4), CYP11B1(4), CYP11B2(5), CYP19A1(13), HEMK1(1), HSD11B1(3), HSD17B1(3), HSD17B12(3), HSD17B2(2), HSD17B3(5), HSD17B7(3), HSD17B8(2), HSD3B1(1), HSD3B2(5), LCMT1(2), LCMT2(8), METTL2B(3), METTL6(3), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), SRD5A1(4), SRD5A2(5), STS(6), SULT1E1(9), SULT2A1(6), SULT2B1(2), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3), WBSCR22(5)	17466640	264	56	251	72	74	100	34	19	35	2	0.48	0.80
371	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(14), BMPR1A(4), BMPR1B(6), BMPR2(9)	2225552	33	19	33	5	10	13	7	0	3	0	0.49	0.80
372	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	13	AANAT(2), ACHE(3), CHAT(1), DBH(7), DDC(9), GAD1(6), GAD2(10), HDC(6), MAOA(10), PAH(1), PNMT(1), TPH1(9)	4825336	65	29	64	16	14	19	17	1	12	2	0.49	0.80
373	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), CDK5R1(2), DRD1(5), DRD2(6), GRM1(18), PLCB1(4), PPP1CA(3), PPP1R1B(2), PPP2CA(4), PPP3CA(2), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3)	5614224	68	31	67	28	19	29	8	2	10	0	0.49	0.80
374	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	9	GCK(3), HK1(9), HK2(5), HK3(8), IMPA1(3), IMPA2(5), PGM1(5), PGM3(4), TGDS(3)	3838296	45	25	45	23	12	15	8	4	6	0	0.49	0.81
375	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	ABP1(5), AGXT(3), AGXT2(8), AKR1B10(3), ALAS1(5), ALAS2(10), AMT(2), AOC2(6), AOC3(9), BHMT(2), CBS(9), CHDH(2), CHKA(7), CTH(4), DAO(3), DLD(3), DMGDH(1), GARS(6), GATM(4), GLDC(13), GNMT(2), HSD3B7(3), MAOA(10), MAOB(5), PEMT(1), PHGDH(5), PIPOX(2), PISD(2), PSAT1(3), PSPH(1), RDH11(1), RDH12(3), RDH13(4), RDH14(2), SARDH(8), SARS(2), SARS2(3), SDS(1), SHMT1(4), SHMT2(2), TARS(5), TARS2(7)	15046904	181	51	176	67	51	71	30	9	20	0	0.49	0.81
376	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(9), F11(9), F12(2), F13B(13), F2(8), F5(36), F7(1), F8(34), F9(10), FGA(23), FGB(4), FGG(9), LPA(11), PLAT(5), PLAU(4), PLG(9), SERPINB2(6), SERPINE1(5), SERPINF2(4), VWF(19)	12544832	221	49	209	62	62	84	40	9	26	0	0.49	0.81
377	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(4), ACAA2(2), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1C4(5), AKR1D1(7), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), BAAT(5), CEL(5), CYP27A1(8), CYP7A1(10), HADHB(3), SOAT2(5), SRD5A1(4), SRD5A2(5)	8363552	120	38	116	30	39	40	19	7	15	0	0.49	0.81
378	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(3), ST3GAL1(1), ST3GAL2(3), ST3GAL4(3), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(3), ST8SIA1(1)	1899928	17	15	17	7	8	5	3	0	1	0	0.50	0.81
379	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	65	CALM2(3), CALML6(3), CDS1(4), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKI(16), DGKZ(8), IMPA1(3), IMPA2(5), INPP1(2), INPP4B(12), INPP5A(4), INPP5B(4), INPP5D(9), ITPK1(2), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), OCRL(15), PI4KA(9), PI4KB(6), PIK3C2A(14), PIK3C2B(10), PIK3C2G(12), PIK3C3(9), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PIP4K2A(2), PIP4K2B(7), PIP4K2C(3), PIP5K1A(6), PIP5K1B(3), PIP5K1C(4), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(3), PLCD4(10), PLCE1(31), PLCG1(8), PLCG2(23), PLCZ1(11), PRKCA(7), PRKCG(6), PTPMT1(1), SYNJ1(24), SYNJ2(8)	40548000	533	89	522	197	143	211	84	28	63	4	0.50	0.81
380	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	56	B3GALNT1(3), B3GALT1(9), B3GALT2(6), B3GALT4(3), B3GALT5(4), B3GNT1(5), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), B4GALNT1(4), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT4(3), B4GALT6(4), FUT1(3), FUT2(1), FUT3(7), FUT6(9), FUT9(7), GBGT1(5), GCNT2(10), PIGA(7), PIGB(9), PIGC(2), PIGF(2), PIGG(4), PIGH(3), PIGK(6), PIGL(1), PIGM(1), PIGN(9), PIGO(6), PIGP(2), PIGS(1), PIGT(7), PIGU(2), PIGV(6), PIGX(2), PIGZ(4), ST3GAL1(1), ST3GAL2(3), ST3GAL3(4), ST3GAL4(3), ST3GAL5(2), ST3GAL6(6), ST6GALNAC3(7), ST6GALNAC4(3), ST6GALNAC5(2), ST6GALNAC6(4), ST8SIA1(1), ST8SIA5(5), UGCG(4)	16131656	222	59	218	49	63	100	24	12	23	0	0.50	0.81
381	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	11	ABL1(5), CDKN2A(1), E2F1(6), MDM2(3), MYC(6), POLR1A(11), POLR1B(10), POLR1C(2), POLR1D(1), RAC1(1), TBX2(2)	4862536	48	28	48	31	12	20	4	8	4	0	0.50	0.81
382	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	43	AKT1(3), AKT2(4), AKT3(7), BAD(2), BCR(4), BLNK(3), BTK(4), CD19(3), CD22(11), CR2(19), CSK(1), DAG1(4), FLOT2(1), GRB2(3), GSK3A(8), GSK3B(8), INPP5D(9), ITPR1(23), ITPR2(25), ITPR3(15), LYN(6), MAP4K1(9), MAPK1(2), MAPK3(3), NFATC2(9), NR0B2(2), PDK1(2), PIK3CD(9), PLCG2(23), PPP1R13B(5), PPP3CA(2), PPP3CB(5), PPP3CC(4), PTPRC(11), RAF1(5), SHC1(5), SOS1(10), SOS2(16), SYK(3), VAV1(10)	24774704	298	73	291	105	89	118	48	12	27	4	0.50	0.81
383	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	ABP1(5), AGXT(3), AGXT2(8), ALAS1(5), ALAS2(10), AMT(2), AOC2(6), AOC3(9), ATP6V0C(1), BHMT(2), CBS(9), CHDH(2), CHKA(7), CPT1B(1), CTH(4), DAO(3), DLD(3), DMGDH(1), GARS(6), GATM(4), GLDC(13), MAOA(10), MAOB(5), PEMT(1), PISD(2), PLCB2(7), PLCG1(8), PLCG2(23), PSPH(1), SARDH(8), SARS(2), SHMT1(4), SHMT2(2), TARS(5)	14641920	182	52	176	57	53	69	27	12	21	0	0.51	0.81
384	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(7), SUCLA2(5)	783184	12	9	11	2	2	9	0	0	1	0	0.51	0.82
385	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT1(3), FUT2(1), FUT3(7), FUT6(9), ST3GAL3(4)	1592160	24	16	24	9	2	18	2	1	1	0	0.51	0.82
386	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	19	IMPA1(3), INPP1(2), INPP4B(12), INPP5A(4), ITPKB(7), OCRL(15), PIK3C2A(14), PIK3C2B(10), PIK3C2G(12), PIK3CB(13), PIK3CG(18), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PLCD1(5), PLCG1(8), PLCG2(23)	13876592	182	52	176	64	51	70	22	11	26	2	0.51	0.82
387	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(4), B3GAT2(1), B3GAT3(1), B4GALT7(3), CHPF(3), CHST11(7), CHST12(3), CHST14(2), CHST3(3), CHST7(4), DSE(14), UST(3), XYLT1(10), XYLT2(3)	4813184	61	29	60	28	14	28	14	2	3	0	0.52	0.82
388	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(3), ALAS1(5), ALAS2(10), CPOX(4), FECH(4), HMBS(5), UROD(1), UROS(3)	2826456	35	18	34	9	5	18	6	2	4	0	0.52	0.82
389	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	42	ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AGPAT2(1), AGPAT3(4), AGPAT4(3), AKR1A1(1), AKR1B1(1), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), CEL(5), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKZ(8), GK(13), GLA(2), GLB1(4), LCT(24), LIPC(5), LIPF(6), LIPG(4), LPL(9), PNLIP(2), PNLIPRP1(3), PNLIPRP2(8), PPAP2A(4), PPAP2B(2)	16470920	222	57	220	63	61	86	33	18	24	0	0.52	0.82
390	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	31	ALDH4A1(1), ARG1(4), ARG2(3), ASL(2), ASS1(2), CKM(2), CKMT1A(1), CKMT2(2), CPS1(19), DAO(3), EPRS(7), GATM(4), GLUD1(3), GLUD2(6), GOT1(5), GOT2(3), LAP3(6), NOS1(14), NOS3(6), OAT(6), OTC(6), P4HA1(5), P4HA2(10), P4HA3(2), PARS2(3), PYCR2(1), PYCRL(1), RARS(9), RARS2(6)	11903008	142	48	139	60	34	64	22	7	11	4	0.52	0.82
391	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL1(3), FOSL2(5), IFNAR1(6), IFNAR2(6), IFNB1(2), MAPK8(7), NFKB1(7), RELA(4), TNFRSF11A(4), TNFSF11(5), TRAF6(3)	4038928	54	27	52	11	14	18	14	2	6	0	0.52	0.82
392	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(42), ATR(26), BRCA1(14), CCNB1(7), CDC25A(7), CDC25B(2), CDC25C(5), CDKN1A(1), CDKN2D(1), CHEK1(2), CHEK2(11), EP300(23), MDM2(3), PRKDC(40), RPS6KA1(1), WEE1(1), YWHAH(2), YWHAQ(1)	15359384	189	50	183	47	32	61	38	14	40	4	0.52	0.82
393	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	33	ARSD(6), ARSE(5), ASAH1(6), B4GALT6(4), CERK(6), DEGS1(5), DEGS2(4), ENPP7(2), GAL3ST1(7), GALC(3), GBA(3), GLA(2), GLB1(4), LCT(24), NEU2(4), NEU3(2), PPAP2A(4), PPAP2B(2), SGMS1(2), SGMS2(3), SGPP1(2), SGPP2(3), SMPD1(10), SMPD2(4), SMPD3(4), SMPD4(7), SPHK1(2), SPHK2(1), SPTLC1(5), SPTLC2(4), UGCG(4), UGT8(11)	11599208	155	47	152	46	48	66	11	10	20	0	0.53	0.82
394	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	36	ALK(13), AR(4), ESR2(4), ESRRA(2), HNF4A(5), NPM1(2), NR0B1(6), NR1D1(3), NR1D2(1), NR1H2(2), NR1H3(4), NR1I2(2), NR1I3(5), NR2C2(5), NR2E1(5), NR2F1(5), NR2F2(5), NR3C1(11), NR4A1(4), NR4A2(6), NR5A2(10), PPARD(3), PPARG(5), RARA(1), RARB(4), RARG(2), ROR1(4), RORA(8), RORC(8), RXRA(1), RXRG(6), THRA(4), THRB(2), VDR(7)	13935864	159	51	154	52	49	70	22	8	10	0	0.53	0.82
395	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(4), BHMT(2), CBS(9), CTH(4), DNMT1(11), DNMT3A(8), DNMT3B(10), MARS(7), MARS2(3), MAT1A(3), MAT2B(10), MTR(7)	6094352	78	33	75	34	20	36	9	2	11	0	0.53	0.82
396	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ACTR2(5), ACTR3(1), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), NCK1(4), NCKAP1(6), NTRK1(11), PIR(4), RAC1(1), WASF1(3), WASF2(3), WASF3(7), WASL(7)	5606536	65	31	65	23	23	28	6	2	6	0	0.53	0.82
397	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(6), CS(5), MDH1(2), ME1(7), PC(9), PDHA1(4), SLC25A1(2), SLC25A11(2)	3281536	37	21	37	20	7	17	6	2	5	0	0.53	0.82
398	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(3), POLD1(11), POLD2(5), POLG(5), POLL(6), POLQ(18)	6123864	48	32	47	13	13	22	8	2	3	0	0.53	0.83
399	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(8), GTF2A1(3), GTF2B(3), GTF2E1(3), GTF2F1(5), HDAC3(8), NCOA1(15), NCOA2(13), NCOA3(8), NCOR2(16), POLR2A(17), RARA(1), RXRA(1), TBP(3)	8342472	104	38	101	40	23	46	20	5	10	0	0.53	0.83
400	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	CSF3(1), EPO(1), FLT3(7), IGF1(2), IL6(4), KITLG(2), TGFB1(2), TGFB2(5), TGFB3(8)	2993360	32	20	32	7	7	17	4	0	4	0	0.54	0.83
401	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	AKT1(3), EGFR(10), IGF1R(10), MYC(6), POLR2A(17), PPP2CA(4), PRKCA(7), TEP1(9), TERF1(1), TERT(3), TNKS(13), XRCC5(5)	9025960	88	36	87	42	20	39	10	6	13	0	0.55	0.84
402	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	44	APAF1(11), BAD(2), BAX(3), BCL2L1(3), BCL2L2(2), CASP1(5), CASP10(8), CASP2(4), CASP3(3), CASP4(5), CASP6(3), CASP7(4), CASP9(2), CD40(2), CD40LG(5), CRADD(2), CYCS(2), DAXX(6), DFFB(3), FAS(6), FASLG(5), IKBKE(1), LTA(2), MCL1(1), NFKB1(7), NFKBIA(2), NGFR(3), NR3C1(11), NTRK1(11), PTPN13(20), RIPK1(8), TFG(2), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(2), TRAF3(4), TRAF6(3)	15221992	173	49	171	48	48	66	26	7	26	0	0.55	0.84
403	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(7), ACADM(4), ACADS(4), ACAT1(4), ECHS1(2), HADHA(5)	1881576	26	15	26	10	3	12	4	4	3	0	0.55	0.84
404	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(11), CALM2(3), CAPN2(5), CAPNS1(1), CAPNS2(3), EP300(23), HDAC1(3), HDAC2(4), MEF2D(5), NFATC2(9), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKCA(7), SYT1(4)	8418856	89	35	88	29	19	28	15	6	19	2	0.55	0.84
405	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(3), ADCY1(12), CAP1(7), CCNB1(7), CDC25C(5), GNAI1(4), GNAS(16), GNB1(1), MAPK1(2), MAPK3(3), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), RPS6KA1(1), SRC(2)	6755272	84	36	81	22	18	39	12	3	12	0	0.55	0.84
406	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(6), AASDHPPT(4), AASS(6), KARS(3)	1715912	19	14	18	7	8	4	5	2	0	0	0.55	0.84
407	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(4), CARM1(4), CBS(9), CTH(4), GGT1(5), HEMK1(1), LCMT1(2), LCMT2(8), MARS(7), MARS2(3), MAT1A(3), MAT2B(10), METTL2B(3), METTL6(3), PAPSS1(5), PAPSS2(5), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), SCLY(2), SEPHS1(10), SEPHS2(3), WBSCR22(5)	8667104	124	38	119	37	37	49	15	5	18	0	0.56	0.84
408	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	30	ACTA1(3), CRK(1), CRKL(4), DOCK1(17), ELK1(2), FOS(2), GAB1(5), GRB2(3), HGF(13), ITGA1(13), ITGB1(5), JUN(1), MAP2K1(2), MAP4K1(9), MAPK1(2), MAPK3(3), MAPK8(7), MET(9), PAK1(1), PTK2(8), PTK2B(13), PTPN11(5), PXN(4), RAF1(5), RAP1A(3), RAP1B(2), SOS1(10), SRC(2), STAT3(8)	13613464	162	56	159	56	45	64	24	8	21	0	0.56	0.84
409	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	22	GPAA1(4), GPLD1(7), PGAP1(8), PIGA(7), PIGB(9), PIGC(2), PIGF(2), PIGG(4), PIGH(3), PIGK(6), PIGL(1), PIGM(1), PIGN(9), PIGO(6), PIGP(2), PIGS(1), PIGT(7), PIGU(2), PIGV(6), PIGW(7), PIGX(2), PIGZ(4)	8335280	100	41	99	18	27	41	14	6	12	0	0.56	0.85
410	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(42), ATR(26), BRCA1(14), BRCA2(42), CHEK1(2), CHEK2(11), FANCC(6), FANCD2(8), FANCE(8), FANCG(7), HUS1(3), MRE11A(9), RAD1(3), RAD17(7), RAD50(15), RAD51(2), RAD9A(2)	15993520	207	54	202	36	48	74	35	11	31	8	0.56	0.85
411	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD28(3), CD3D(3), CD3E(1), CD3G(1), CD80(5), CD86(4), CTLA4(2), GRB2(3), ICOS(2), IL2(2), ITK(5), LCK(3), PTPN11(5)	3326176	39	22	39	11	10	18	6	1	4	0	0.57	0.85
412	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(7), MAP3K14(4), MAPK14(4), MAPK8(7), NFKB1(7), RELA(4), TNFRSF13B(1), TNFSF13B(2), TRAF2(2), TRAF3(4), TRAF5(6), TRAF6(3)	5151456	51	28	50	16	9	21	9	3	9	0	0.57	0.85
413	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(4), ACAT2(4), BDH1(3), BDH2(4), HMGCL(2), HMGCS1(3), HMGCS2(6), OXCT1(8), OXCT2(2)	2530096	36	21	36	6	13	15	2	2	4	0	0.57	0.85
414	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(3), BAD(2), CHRNB1(2), CHRNG(2), MUSK(11), PTK2(8), PTK2B(13), RAPSN(1), SRC(2), TERT(3), YWHAH(2)	4234848	49	27	49	28	15	21	7	4	2	0	0.57	0.85
415	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	12	ARF1(3), ARF3(2), CDK2(2), CDK4(3), CDKN1A(1), CDKN2A(1), CFL1(1), E2F1(6), E2F2(2), MDM2(3), PRB1(2)	2280608	26	17	26	14	4	11	6	4	1	0	0.57	0.85
416	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(9), HK2(5), HK3(8), IMPA1(3), PGM1(5), PGM3(4), TGDS(3)	3653784	40	23	40	23	12	11	8	4	5	0	0.58	0.85
417	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(16), JAK2(14), JAK3(5), MAPK1(2), MAPK3(3), STAT3(8), TYK2(4)	4198888	52	25	52	23	5	21	10	3	9	4	0.58	0.85
418	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	18	B3GNT1(5), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT4(3), FUT1(3), FUT2(1), FUT3(7), FUT6(9), FUT9(7), GCNT2(10), ST3GAL6(6), ST8SIA1(1)	5107064	72	28	71	14	17	37	6	4	8	0	0.58	0.85
419	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(6), AASDHPPT(4), AASS(6), ACAT1(4), ACAT2(4), AKR1B10(3), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), DLST(8), DOT1L(5), ECHS1(2), EHHADH(4), EHMT2(1), GCDH(5), HADH(1), HADHA(5), HSD17B10(2), HSD17B4(8), HSD3B7(3), NSD1(25), OGDH(9), OGDHL(15), PIPOX(2), PLOD1(3), PLOD2(13), PLOD3(6), RDH11(1), RDH12(3), RDH13(4), RDH14(2), SETD1A(9), SETD7(5), SETDB1(14), SHMT1(4), SHMT2(2), SPCS3(2), SUV39H1(7), SUV39H2(2), TMLHE(4)	20225392	216	62	210	66	55	87	39	14	19	2	0.58	0.85
420	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB11A(1), RAB1A(3), RAB27A(2), RAB3A(2), RAB4A(4), RAB5A(1), RAB6A(1), RAB9A(6)	1595136	23	14	22	7	9	8	3	0	3	0	0.59	0.86
421	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	41	ABCA1(21), ABCA10(20), ABCA12(37), ABCA13(57), ABCA3(9), ABCA4(23), ABCA5(22), ABCA6(15), ABCA8(23), ABCA9(22), ABCB10(8), ABCB11(13), ABCB4(24), ABCB5(22), ABCB6(7), ABCB7(15), ABCB8(3), ABCB9(7), ABCC1(12), ABCC10(7), ABCC11(21), ABCC12(18), ABCC2(23), ABCC3(8), ABCC4(6), ABCC5(7), ABCC6(13), ABCC8(17), ABCC9(22), ABCD1(11), ABCD2(7), ABCD3(7), ABCD4(2), ABCG1(6), ABCG2(8), ABCG4(6), ABCG5(2), ABCG8(7), CFTR(12), TAP1(6)	39697608	576	91	558	151	141	236	74	36	78	11	0.59	0.86
422	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	11	ACTN1(7), ACTN2(7), ACTN3(6), CSK(1), CTNNA1(15), CTNNA2(9), PTK2(8), PXN(4), SRC(2), VCL(8)	6287792	67	32	64	32	22	19	9	2	15	0	0.59	0.86
423	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(12), CREM(3), FHL5(4), FSHR(14), GNAS(16), XPO1(12)	3251280	61	24	57	14	20	27	9	1	4	0	0.59	0.86
424	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(5), CHIA(2), CHIT1(4), CMAS(4), CTBS(3), CYB5R1(3), CYB5R3(5), GFPT1(8), GFPT2(10), GNE(8), GNPDA1(1), GNPDA2(6), GNPNAT1(1), HEXA(1), HEXB(3), HK1(9), HK2(5), HK3(8), LHPP(2), MTMR1(13), MTMR2(2), MTMR6(7), NAGK(1), NANS(4), NPL(5), PGM3(4), PHPT1(1), RENBP(3), UAP1(5)	10217848	133	44	131	47	31	49	22	7	24	0	0.59	0.86
425	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(15), COL4A2(5), COL4A3(19), COL4A4(17), COL4A5(19), COL4A6(28), F10(9), F11(9), F12(2), F2(8), F2R(6), F5(36), F8(34), F9(10), FGA(23), FGB(4), FGG(9), KLKB1(10), PROC(3), PROS1(1), SERPINC1(5), SERPING1(6)	16154472	278	56	267	64	83	100	43	15	32	5	0.59	0.86
426	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(9), B3GALT2(6), B3GALT5(4), B3GNT5(4), FUT1(3), FUT2(1), FUT3(7), ST3GAL3(4), ST3GAL4(3)	2672200	41	21	39	11	9	20	5	2	5	0	0.60	0.86
427	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(11), G6PD(3), GCLC(5), GCLM(2), GGT1(5), GPX3(2), GPX5(5), GPX6(6), GPX7(1), GSR(4), GSS(3), GSTA1(2), GSTA2(4), GSTA3(2), GSTA4(3), GSTA5(3), GSTK1(3), GSTM1(2), GSTM2(1), GSTM3(4), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(4), IDH1(3), IDH2(4), MGST1(4), MGST3(1), TXNDC12(4)	7264912	96	38	93	34	28	33	14	11	8	2	0.60	0.86
428	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	8	ESR2(4), PDE1A(10), PDE1B(6), PLCB1(4), PLCB2(7), PRL(4), VIP(1)	3501264	36	24	36	19	12	13	6	2	3	0	0.60	0.86
429	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(3), CDKN1A(1), NFATC2(9), NFATC3(9), NFATC4(7), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PRKCA(7), SP1(6), SP3(8), SYT1(4)	7233416	73	33	70	29	21	24	12	5	11	0	0.60	0.86
430	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(3), CASP7(4), DFFB(3), GZMB(2), HMGB1(2), HMGB2(4), TOP2A(11), TOP2B(19)	3651800	48	24	47	13	4	15	11	5	13	0	0.60	0.86
431	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	19	APAF1(11), ARHGDIB(1), BIRC2(10), BIRC3(2), CASP1(5), CASP10(8), CASP2(4), CASP3(3), CASP4(5), CASP6(3), CASP7(4), CASP9(2), CYCS(2), DFFB(3), GZMB(2), LMNA(5), LMNB1(4), PRF1(6)	6247616	80	29	76	20	23	28	12	2	15	0	0.61	0.86
432	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	ABP1(5), ACY1(3), ADC(5), AGMAT(3), ALDH18A1(9), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(9), ARG1(4), ARG2(3), ASL(2), ASS1(2), CPS1(19), GATM(4), MAOA(10), MAOB(5), ODC1(1), OTC(6), SAT1(5), SMS(7), SRM(1)	10386984	124	43	120	51	37	47	14	8	14	4	0.61	0.86
433	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(3), HDAC9(14), MEF2A(3), MEF2B(1), MEF2C(8), MEF2D(5), MYOD1(3), YWHAH(2)	2920944	41	21	39	13	5	22	6	2	6	0	0.61	0.86
434	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(1), AKR1B10(3), ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), FPGT(6), FUK(4), GMDS(3), GMPPA(5), GMPPB(1), HK1(9), HK2(5), HK3(8), HSD3B7(3), KHK(1), LHPP(2), MPI(3), MTMR1(13), MTMR2(2), MTMR6(7), PFKFB1(7), PFKFB2(1), PFKFB3(4), PFKFB4(3), PFKM(4), PFKP(6), PGM2(4), PHPT1(1), PMM2(6), RDH11(1), RDH12(3), RDH13(4), RDH14(2), SORD(3), TSTA3(3)	12474400	143	50	139	55	32	57	21	9	24	0	0.61	0.87
435	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(4), ACAA2(2), ACAD8(4), ACAD9(8), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1B10(3), AKR1C4(5), AKR1D1(7), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), BAAT(5), CEL(5), CYP27A1(8), CYP7A1(10), HADHB(3), HSD3B7(3), LIPA(5), RDH11(1), RDH12(3), RDH13(4), RDH14(2), SLC27A5(3), SOAT1(7), SOAT2(5), SRD5A1(4), SRD5A2(5)	11266888	151	44	147	37	49	53	23	7	17	2	0.61	0.87
436	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(3), LIPT1(5)	549816	8	7	8	1	1	4	2	0	1	0	0.62	0.87
437	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(5), FARSB(5), GOT1(5), GOT2(3), PAH(1), TAT(5), YARS(4), YARS2(2)	3187544	32	21	32	9	10	11	6	5	0	0	0.62	0.87
438	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(3), CD36(5), FOS(2), FYN(6), JUN(1), MAPK14(4), THBS1(9)	2701216	30	19	30	7	8	11	2	4	5	0	0.62	0.87
439	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(4), C1QB(2), C1R(9), C1S(5), C2(3), C3(18), C5(14), C6(13), C7(16), C8A(9)	5983496	93	32	89	31	17	43	13	5	11	4	0.62	0.87
440	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	18	CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), DAG1(4), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), NFAT5(10), PDE6A(9), PDE6B(5), PDE6C(10), PDE6D(1), SLC6A13(6), TF(12)	12596168	141	47	139	54	40	55	18	3	23	2	0.62	0.87
441	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(3), ANKRD1(3), ATF3(3), CYR61(2), DUSP14(3), EIF4E(2), HBEGF(2), IFNG(5), IFRD1(6), IL18(1), IL1R1(4), MYOG(1), NR4A3(8), WDR1(9)	3764144	52	24	52	16	16	15	11	2	8	0	0.62	0.87
442	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	ARSB(4), GLB1(4), GNS(1), GUSB(4), HEXA(1), HEXB(3), HGSNAT(7), HPSE(3), HPSE2(5), HYAL1(2), HYAL2(2), IDS(5), LCT(24), NAGLU(2), SPAM1(11)	7048656	78	34	78	40	18	36	9	7	8	0	0.63	0.87
443	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(2), FDFT1(1), FDPS(6), HMGCR(9), HMGCS1(3), IDI1(3), MVD(3), MVK(3), NSDHL(9), PMVK(2), SC5DL(2), SQLE(4)	4303792	50	25	49	21	18	14	8	3	7	0	0.63	0.87
444	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	46	ACAA1(4), ACAA2(2), ACADL(7), ACADM(4), ACADS(4), ACADSB(4), ACADVL(4), ACAT1(4), ACAT2(4), ACOX1(3), ACOX3(5), ACSL1(9), ACSL3(6), ACSL5(8), ACSL6(9), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CPT1A(6), CPT1B(1), CPT1C(11), CPT2(4), CYP4A11(4), CYP4A22(5), ECHS1(2), EHHADH(4), GCDH(5), HADH(1), HADHA(5), HADHB(3), HSD17B10(2), HSD17B4(8)	16891776	183	51	179	49	40	76	35	9	23	0	0.63	0.87
445	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(5), AOC2(6), AOC3(9), CES1(11), ESD(1)	2289040	32	18	29	13	10	8	8	3	3	0	0.63	0.87
446	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	87	AKT1(3), AKT2(4), AKT3(7), BCL10(2), CARD11(13), CBL(8), CBLB(11), CBLC(4), CD247(3), CD28(3), CD3D(3), CD3E(1), CD3G(1), CD4(6), CD40LG(5), CD8A(2), CD8B(1), CDC42(4), CDK4(3), CHUK(7), CTLA4(2), FOS(2), FYN(6), GRB2(3), ICOS(2), IFNG(5), IKBKB(8), IL10(2), IL2(2), IL5(1), ITK(5), JUN(1), LCK(3), LCP2(4), MALT1(3), MAP3K14(4), MAP3K8(6), NCK1(4), NCK2(7), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PDK1(2), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG1(8), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), PRKCQ(6), PTPRC(11), RASGRP1(6), RHOA(3), SOS1(10), SOS2(16), TEC(5), VAV1(10), VAV2(3), VAV3(9), ZAP70(6)	33617640	410	78	403	136	115	149	60	26	58	2	0.63	0.87
447	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(4), CHPT1(1), HEMK1(1), LCMT1(2), LCMT2(8), METTL2B(3), METTL6(3), PCYT1A(1), PCYT1B(3), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), WBSCR22(5)	4952808	59	26	57	17	17	20	6	3	13	0	0.63	0.87
448	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	64	ACAA1(4), ACADL(7), ACADM(4), ACOX1(3), ACOX2(6), ACOX3(5), ACSL1(9), ACSL3(6), ACSL5(8), ACSL6(9), ADIPOQ(2), APOA2(1), APOA5(1), AQP7(4), CD36(5), CPT1A(6), CPT1B(1), CPT1C(11), CPT2(4), CYP27A1(8), CYP4A11(4), CYP4A22(5), CYP7A1(10), CYP8B1(4), DBI(1), EHHADH(4), FABP1(4), FABP2(2), FABP3(1), FABP5(3), FABP6(3), FABP7(2), FADS2(1), GK(13), GK2(18), HMGCS2(6), ILK(4), LPL(9), ME1(7), MMP1(1), NR1H3(4), OLR1(1), PCK1(8), PCK2(7), PDPK1(2), PLTP(3), PPARD(3), PPARG(5), RXRA(1), RXRG(6), SCD(6), SCP2(8), SLC27A1(8), SLC27A2(2), SLC27A4(3), SLC27A5(3), SLC27A6(9), SORBS1(14), UBC(7), UCP1(1)	22920408	307	68	300	85	79	129	48	15	36	0	0.63	0.87
449	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(3), CD3E(1), CD3G(1), CD4(6), FYN(6), LCK(3), PTPRC(11), ZAP70(6)	3304600	37	21	37	8	6	16	4	1	10	0	0.64	0.87
450	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(27), ACAT1(4), ACAT2(4), ACYP1(2), AKR1B1(1), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), DLAT(1), DLD(3), GRHPR(3), LDHA(6), LDHB(2), LDHC(4), LDHD(1), MDH1(2), MDH2(4), ME1(7), ME2(5), ME3(6), PC(9), PCK1(8), PDHA1(4), PDHA2(8), PDHB(3), PKLR(5), PKM2(4)	12873680	148	49	146	54	39	56	18	8	27	0	0.64	0.87
451	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(7), CDC25B(2), CDK7(4), CDKN1A(1), CHEK1(2), NEK1(17), WEE1(1)	2677656	34	20	32	3	11	12	4	1	6	0	0.64	0.87
452	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(4), CBS(9), CTH(4), GGT1(5), MARS(7), MARS2(3), MAT1A(3), MAT2B(10), PAPSS1(5), PAPSS2(5), SCLY(2), SEPHS1(10)	4285936	67	26	64	24	21	29	9	2	6	0	0.64	0.87
453	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(4), AMD1(2), BHMT(2), CBS(9), CTH(4), DNMT1(11), DNMT3A(8), DNMT3B(10), MARS(7), MARS2(3), MAT1A(3), MAT2B(10), MTAP(2), MTR(7), SRM(1), TAT(5)	7179600	88	35	85	42	22	41	11	3	11	0	0.64	0.87
454	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(6), CARS(6), DARS(4), EPRS(7), FARS2(2), GARS(6), HARS(3), IARS(7), KARS(3), LARS(16), LARS2(7), MARS(7), MARS2(3), NARS(7), QARS(4), RARS(9), SARS(2), TARS(5), WARS(5), WARS2(2), YARS(4)	11726680	115	43	115	48	26	53	21	5	10	0	0.64	0.87
455	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(7), CCNH(3), CDC25A(7), CDC25B(2), CDC25C(5), CDK7(4), SHH(4), XPO1(12)	3142656	44	22	42	9	10	16	10	2	6	0	0.65	0.87
456	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	40	ACTG1(1), ADCY3(5), ADCY9(17), ARF1(3), ARF3(2), ARF4(2), ARF5(4), ARF6(2), ARL4D(1), ATP6V0A1(5), ATP6V0A2(10), ATP6V0A4(10), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(7), ATP6V1A(5), ATP6V1C1(3), ATP6V1D(2), ATP6V1E1(3), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(5), ERO1L(5), GNAS(16), PDIA4(3), PLCG1(8), PLCG2(23), PRKCA(7), SEC61A1(2), SEC61A2(3), SEC61B(1), SEC61G(3), TRIM23(11)	12779936	187	50	181	44	53	85	15	9	23	2	0.65	0.87
457	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(10), ACE2(17), AGT(7), AGTR1(1), AGTR2(7), ANPEP(11), CMA1(1), CPA3(4), CTSA(8), CTSG(3), ENPEP(12), LNPEP(6), MAS1(1), MME(6), NLN(4), REN(1)	7290704	99	35	95	33	31	35	16	6	9	2	0.65	0.87
458	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(10), ACO2(5), CS(5), GRHPR(3), HAO1(1), HAO2(7), HYI(2), MDH1(2), MDH2(4), MTHFD1(4), MTHFD1L(11), MTHFD2(2)	4654216	56	29	55	22	21	20	7	5	3	0	0.65	0.87
459	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	33	ACTA1(3), ACTN1(7), ACTN2(7), ACTN3(6), BCR(4), CAPN1(2), CAPNS1(1), CAPNS2(3), CRKL(4), CSK(1), FYN(6), GRB2(3), ITGA1(13), ITGB1(5), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(3), MAPK8(7), PPP1R12B(11), PTK2(8), PXN(4), RAF1(5), RAP1A(3), ROCK1(15), SHC1(5), SOS1(10), SRC(2), TLN1(20), VCL(8), ZYX(11)	16047832	182	55	178	48	60	69	24	7	20	2	0.65	0.87
460	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ABP1(5), ACY3(3), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH7A1(2), ALDH9A1(1), AMDHD1(10), AOC2(6), AOC3(9), ASPA(4), CARM1(4), CNDP1(4), DDC(9), HAL(4), HARS(3), HARS2(6), HDC(6), HEMK1(1), HNMT(4), LCMT1(2), LCMT2(8), MAOA(10), MAOB(5), METTL2B(3), METTL6(3), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), PRPS1(3), PRPS2(6), UROC1(8), WBSCR22(5)	13852536	177	49	171	53	53	58	26	11	29	0	0.65	0.87
461	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(4), GSS(3), IL8(3), NFKB1(7), NOX1(10), RELA(4), SOD1(2), XDH(9)	3707352	42	22	42	11	12	14	8	2	6	0	0.65	0.87
462	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT4(3), CHST1(8), CHST2(1), CHST4(1), FUT8(12), ST3GAL1(1), ST3GAL2(3), ST3GAL3(4), ST3GAL4(3)	3989576	56	27	52	22	18	26	8	1	3	0	0.66	0.87
463	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ACTR2(5), ACTR3(1), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), CDC42(4), RAC1(1), WASF1(3), WASL(7)	2992864	34	20	34	10	10	15	2	0	7	0	0.66	0.87
464	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	14	ACADL(7), ACADM(4), ACADS(4), ACADVL(4), ACSL1(9), ACSL3(6), CPT1A(6), CPT2(4), EHHADH(4), HADHA(5), PECR(4), SCP2(8), SLC25A20(3)	5512792	68	29	65	22	15	25	14	4	10	0	0.66	0.87
465	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), FPGT(6), GCK(3), GMDS(3), GMPPA(5), GMPPB(1), HK1(9), HK2(5), HK3(8), KHK(1), MPI(3), PFKFB1(7), PFKFB3(4), PFKFB4(3), PFKM(4), PFKP(6), PMM2(6), SORD(3)	8502432	93	39	92	41	22	39	13	7	12	0	0.66	0.88
466	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	52	BAK1(3), BAX(3), BFAR(6), BTK(4), CAD(21), CASP10(8), CASP3(3), CASP8AP2(3), CDK2AP1(1), CSNK1A1(4), DAXX(6), DEDD(1), DEDD2(2), DIABLO(2), EGFR(10), EPHB2(8), FAF1(6), FAIM2(2), IL8(3), MAP2K4(4), MAP3K1(24), MAP3K5(19), MAPK1(2), MAPK10(7), MAPK8(7), MAPK8IP1(4), MAPK9(4), MET(9), NFAT5(10), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), NR0B2(2), PFN1(1), PFN2(1), PTPN13(20), RALBP1(4), RIPK1(8), ROCK1(15), SMPD1(10), TPX2(10), TRAF2(2), TUFM(4)	24313920	288	66	279	78	64	122	34	12	50	6	0.66	0.88
467	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(14), PDXK(3), PNPO(1), PSAT1(3)	1675736	21	15	21	11	6	8	3	1	3	0	0.67	0.88
468	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(4), ENO2(3), ENO3(3), FARS2(2), GOT1(5), GOT2(3), PAH(1), TAT(5), YARS(4)	3036264	30	18	30	8	5	13	5	5	2	0	0.67	0.88
469	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(4), ADORA2B(1), ADORA3(3), LTB4R(2), P2RY1(2), P2RY2(3), P2RY6(3)	2076504	21	17	21	11	6	7	6	2	0	0	0.67	0.88
470	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(6), AARS2(5), CARS(6), DARS(4), DARS2(6), EARS2(3), EPRS(7), FARS2(2), FARSA(5), FARSB(5), GARS(6), HARS(3), HARS2(6), IARS(7), IARS2(13), KARS(3), LARS(16), LARS2(7), MARS(7), MARS2(3), NARS(7), NARS2(6), PARS2(3), QARS(4), RARS(9), RARS2(6), SARS(2), SARS2(3), TARS(5), TARS2(7), VARS(4), WARS(5), WARS2(2), YARS(4), YARS2(2)	19823384	189	61	188	71	48	86	31	9	15	0	0.67	0.88
471	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	17	EXT1(10), EXT2(6), EXTL1(9), EXTL2(7), EXTL3(6), GLCE(2), HS2ST1(5), HS3ST1(4), HS3ST2(3), HS3ST3A1(2), HS3ST5(9), HS6ST2(9), HS6ST3(2), NDST1(11), NDST2(4), NDST3(12), NDST4(11)	7166208	112	37	110	32	26	50	17	4	13	2	0.68	0.88
472	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(5), CS(5), FH(8), IDH2(4), MDH1(2), OGDH(9), SDHA(10), SUCLA2(5)	3451416	48	23	48	19	12	25	5	4	2	0	0.68	0.89
473	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	41	CBL(8), CD28(3), CD3D(3), CSK(1), CTLA4(2), DAG1(4), EPHB2(8), GRB2(3), ITK(5), ITPKB(7), LCK(3), LCP2(4), MAPK1(2), NCK1(4), NFAT5(10), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), NFKBIL1(2), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PLCG1(8), PTPRC(11), RAF1(5), RASGRP1(6), RASGRP2(2), RASGRP3(5), RASGRP4(5), SOS1(10), SOS2(16), VAV1(10), ZAP70(6)	18881976	201	58	196	79	61	72	28	9	29	2	0.69	0.89
474	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(18), ARHGEF1(9), GNA12(7), GNA13(7), GNB1(1), MYL2(1), MYLK(10), PLCB1(4), PPP1R12B(11), PRKCA(7), ROCK1(15)	7568216	90	34	88	30	30	30	12	6	6	6	0.69	0.89
475	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(43), MAP2(21), PPP1CA(3), PPP2CA(4), PRKACG(7), PRKAG1(2), PRKAR2A(3), PRKAR2B(3), PRKCE(7)	6711624	93	33	91	21	17	35	17	3	18	3	0.69	0.90
476	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	5	ASAH1(6), DAG1(4), ITPKB(7)	1915800	17	16	17	11	6	7	1	0	3	0	0.70	0.90
477	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(3), IL1B(2), MST1(3), MST1R(9)	2187608	17	13	16	8	7	4	1	1	4	0	0.70	0.90
478	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(6), AASDH(7), AASDHPPT(4), AASS(6), KARS(3)	2547456	26	18	25	12	10	5	7	2	2	0	0.70	0.90
479	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(1), FDPS(6), HMGCR(9), IDI1(3), MVD(3), MVK(3), NQO1(3), NQO2(4), PMVK(2), SC5DL(2), SQLE(4), VKORC1(1)	3534000	43	22	41	19	13	16	6	3	5	0	0.70	0.90
480	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(7), DNAJC3(5), EIF2S2(5), MAP3K14(4), NFKB1(7), NFKBIA(2), RELA(4)	3211848	34	20	33	7	6	11	8	3	6	0	0.70	0.90
481	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(11), BIRC2(10), BIRC3(2), CASP10(8), CASP3(3), CASP7(4), CASP9(2), DFFB(3), GZMB(2), PRF1(6), SCAP(10), SREBF1(2), SREBF2(8)	5638280	71	30	68	20	22	23	9	3	14	0	0.70	0.90
482	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	8	BAG4(3), BIRC3(2), RIPK1(8), TNFRSF1A(4), TNFRSF1B(1), TRAF2(2)	2396672	20	15	20	4	3	8	3	1	5	0	0.71	0.90
483	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(3), CAMK1(2), CAMK1G(3), CAMK2A(6), CAMK2B(1), CAMK2D(3), CAMK2G(4), CAMK4(3), CAMKK1(9), CAMKK2(6), CREB1(5), SYT1(4)	3969488	49	26	48	11	11	23	5	2	8	0	0.71	0.90
484	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	24	ARHGDIB(1), CASP10(8), CASP3(3), CASP6(3), CASP7(4), CFLAR(5), DAXX(6), DFFB(3), FAF1(6), JUN(1), LMNA(5), LMNB1(4), MAP2K4(4), MAP3K1(24), MAP3K7(8), MAPK8(7), PAK1(1), PAK2(3), PRKDC(40), PTPN13(20), RIPK2(5), SPTAN1(23)	14102024	184	50	180	51	54	59	27	11	31	2	0.71	0.90
485	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	17	AKT1(3), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), E2F1(6), MAPK1(2), MAPK3(3), NFKB1(7), NFKBIA(2), PAK1(1), RAC1(1), RAF1(5), RELA(4)	4934208	43	24	43	16	3	21	10	4	5	0	0.71	0.90
486	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(3), LDLR(6), MBTPS1(9), MBTPS2(8), SCAP(10), SREBF1(2), SREBF2(8)	3681808	46	24	45	17	11	22	5	2	6	0	0.72	0.91
487	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), TGDS(3), UGDH(2), UGP2(5), UXS1(5)	1864216	17	14	16	7	5	6	3	1	2	0	0.72	0.91
488	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	5	ABCB11(13), ABCB4(24), ABCC1(12), ABCC3(8), GSTP1(2)	4420104	59	23	59	22	17	16	10	6	10	0	0.72	0.91
489	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(3), CDK7(4), ERCC3(8), GTF2B(3), GTF2E1(3), GTF2E2(2), GTF2H1(6), ILK(4), POLR1A(11), POLR1B(10), POLR2A(17), POLR2B(14), POLR2C(3), POLR2E(1), POLR2F(2), POLR2H(1), POLR2J(1), POLR2K(2), POLR3B(6), POLR3D(2), POLR3E(3), POLR3H(3), TAF5(5), TAF6(6), TAF7(3), TAF9(2), TBP(3)	12831520	128	45	126	45	29	55	16	11	17	0	0.72	0.91
490	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(5), CYP2C9(4)	748464	9	7	9	3	4	4	0	0	1	0	0.72	0.91
491	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(3)	268832	3	2	3	0	1	2	0	0	0	0	0.73	0.91
492	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(13), HSD17B1(3), HSD17B2(2), HSD17B3(5), HSD17B4(8), HSD17B7(3), HSD3B1(1), HSD3B2(5)	2945000	41	22	38	17	12	18	3	1	7	0	0.73	0.91
493	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(3), APAF1(11), CASP3(3), CASP9(2), CYCS(2), DAXX(6), FAS(6), FASLG(5), HSPB2(1), MAPKAPK2(4), MAPKAPK3(2)	3952376	45	24	45	11	13	15	8	3	6	0	0.73	0.91
494	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(4), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB10(3), PSMB2(2), PSMB3(1), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(1), PSMB8(2), PSMB9(1)	3166216	34	20	32	11	4	14	5	2	9	0	0.74	0.92
495	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(4), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB2(2), PSMB3(1), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(1), PSMD14(2), RPN1(2), RPN2(5), UBE2A(3), UBE3A(11)	4810456	51	25	49	17	7	22	7	3	12	0	0.75	0.92
496	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ABP1(5), ACAT1(4), ACAT2(4), ACMSD(8), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), AOC2(6), AOC3(9), AOX1(14), ASMT(3), CAT(3), CYP19A1(13), CYP1A1(9), CYP1A2(5), CYP2A13(6), CYP2A6(10), CYP2A7(4), CYP2B6(11), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2D6(1), CYP2E1(1), CYP2F1(3), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(6), CYP4B1(2), CYP4F8(6), CYP51A1(3), DDC(9), ECHS1(2), EHHADH(4), GCDH(5), HAAO(2), HADHA(5), KMO(7), KYNU(3), MAOA(10), MAOB(5), SDS(1), TDO2(2), TPH1(9), WARS(5), WARS2(2)	20085024	266	60	262	87	76	96	40	18	32	4	0.75	0.92
497	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(3), BAD(2), BCL2L1(3), CASP9(2), CDC42(4), CHUK(7), ELK1(2), H2AFX(1), MAP2K1(2), MAPK3(3), NFKB1(7), RAC1(1), RAF1(5), RALA(3), RALBP1(4), RALGDS(9), RELA(4), RHOA(3)	5353080	65	28	63	13	13	31	12	2	7	0	0.75	0.92
498	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(4), C1QB(2), C1R(9), C1S(5), C2(3), C3(18), C5(14), C6(13), C7(16), C8A(9), MASP1(9), MASP2(5), MBL2(3)	7296160	110	35	105	40	23	54	13	5	11	4	0.75	0.92
499	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYA(6), NFYB(2), NFYC(1), SP1(6), SP3(8)	1793040	23	15	22	6	1	11	6	1	4	0	0.75	0.92
500	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(4), ALDOB(6), ALDOC(3), DERA(8), FBP1(2), G6PD(3), GPI(5), H6PD(4), PFKM(4), PFKP(6), PGD(2), PGLS(1), PGM1(5), PGM3(4), PRPS1(3), PRPS1L1(2), PRPS2(6), RPE(2), RPIA(7), TALDO1(3), TKT(4), TKTL1(7), TKTL2(12)	8161928	103	39	98	35	28	43	14	5	13	0	0.75	0.92
501	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	27	ATG12(1), ATG3(2), ATG5(3), ATG7(2), GABARAP(1), GABARAPL1(2), IFNA10(2), IFNA13(3), IFNA14(2), IFNA16(2), IFNA17(2), IFNA2(1), IFNA21(1), IFNA4(2), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(2), IFNG(5), PIK3C3(9), PIK3R4(17), PRKAA1(5), PRKAA2(7), ULK2(7), ULK3(5)	7000048	88	32	88	24	27	35	12	4	10	0	0.75	0.92
502	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	56	AKT1(3), AKT2(4), AKT3(7), BCL10(2), BLNK(3), BTK(4), CARD11(13), CD19(3), CD22(11), CD72(1), CD79B(2), CHUK(7), CR2(19), FCGR2B(3), FOS(2), GSK3B(8), IKBKB(8), INPP5D(9), JUN(1), LILRB3(2), LYN(6), MALT1(3), NFAT5(10), NFATC2(9), NFATC3(9), NFATC4(7), NFKB1(7), NFKB2(9), NFKBIA(2), NFKBIE(5), PIK3CB(13), PIK3CD(9), PIK3CG(18), PIK3R2(3), PIK3R3(9), PIK3R5(7), PLCG2(23), PPP3CA(2), PPP3CB(5), PPP3CC(4), PPP3R2(1), RAC1(1), RAC2(2), RASGRP3(5), SYK(3), VAV1(10), VAV2(3), VAV3(9)	23831808	306	67	303	104	89	120	40	16	41	0	0.76	0.92
503	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(4), COQ5(3), COQ6(3), COQ7(3), NDUFA13(1)	1462208	14	12	14	5	2	7	3	0	2	0	0.76	0.92
504	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(2), BNIP1(2), SNAP23(1), SNAP25(7), SNAP29(1), STX10(1), STX11(3), STX12(3), STX16(1), STX17(1), STX18(1), STX3(6), STX4(4), STX5(5), STX6(3), STX7(4), STX8(2), TSNARE1(3), USE1(4), VAMP1(1), VAMP4(1), VTI1B(5), YKT6(4)	5946048	65	31	62	24	15	30	8	3	9	0	0.76	0.92
505	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(13), MTMR2(2), MTMR6(7), NFS1(2), PHPT1(1), TPK1(2)	2294000	29	16	28	12	5	9	6	0	9	0	0.76	0.92
506	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(2), HADH(1), HADHA(5), HADHB(3), HSD17B10(2), HSD17B4(8), MECR(6), PPT1(2), PPT2(1)	3002784	32	20	31	7	6	11	7	7	1	0	0.76	0.92
507	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	88	ADCY1(12), ADCY2(10), ADCY3(5), ADCY4(7), ADCY5(11), ADCY6(10), ADCY7(5), ADCY8(15), ADCY9(17), ADRB1(1), DRD1(5), DRD2(6), EGF(17), EGFR(10), GJA1(5), GJD2(6), GNA11(2), GNAI1(4), GNAI2(4), GNAI3(3), GNAS(16), GRB2(3), GRM1(18), GRM5(19), GUCY1A2(9), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(6), GUCY2F(21), HTR2A(9), HTR2B(2), HTR2C(13), ITPR1(23), ITPR2(25), ITPR3(15), MAP2K1(2), MAP2K5(2), MAP3K2(8), MAPK1(2), MAPK3(3), MAPK7(11), NPR1(10), NPR2(10), PDGFB(2), PDGFC(2), PDGFD(6), PDGFRA(19), PDGFRB(10), PLCB1(4), PLCB2(7), PLCB3(9), PLCB4(16), PRKACA(4), PRKACG(7), PRKCA(7), PRKCG(6), PRKG1(4), PRKG2(8), PRKX(2), RAF1(5), SOS1(10), SOS2(16), SRC(2), TJP1(18), TUBA1A(6), TUBA1B(1), TUBA1C(5), TUBA3C(3), TUBA3D(2), TUBA3E(10), TUBA4A(7), TUBA8(7), TUBAL3(3), TUBB1(5), TUBB2A(2), TUBB2B(1), TUBB6(4), TUBB8(3)	46461064	631	93	615	197	170	253	100	31	71	6	0.76	0.92
508	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(7), NFKBIA(2), PLCB1(4), PRKCA(7), RELA(4)	3000800	24	18	24	16	2	10	6	3	3	0	0.76	0.92
509	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(8), CLOCK(6), CRY1(5), CRY2(2), CSNK1E(3), NPAS2(7), NR1D1(3), PER1(9), PER2(6), PER3(10)	5806176	59	29	56	16	21	21	7	2	8	0	0.76	0.92
510	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(6), BFAR(6), BRAF(9), CREB1(5), CREB5(3), MAPK1(2), RAF1(5), SNX13(11), SRC(2), TERF2IP(2)	4115560	51	23	51	10	9	19	11	3	9	0	0.76	0.92
511	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), HEMK1(1), LCMT1(2), LCMT2(8), METTL2B(3), METTL6(3), PRMT3(8), PRMT5(8), PRMT6(5), PRMT7(3), PRMT8(4), WBSCR22(5)	5201304	68	26	66	14	18	25	7	3	15	0	0.76	0.92
512	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(7), AMT(2), ATIC(6), ATP6V0C(1), DHFR(3), GART(6), MTHFD1(4), MTHFD1L(11), MTHFD2(2), MTHFR(5), MTR(7), SHMT1(4), SHMT2(2)	6538024	60	31	58	22	14	30	6	3	7	0	0.77	0.93
513	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(8), CLOCK(6), CRY1(5), CRY2(2), CSNK1E(3), PER1(9)	2852744	33	19	32	9	13	10	5	1	4	0	0.77	0.93
514	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(8), F2R(6), GNAI1(4), GNB1(1), ITGA1(13), ITGB1(5), MAP2K1(2), MAPK1(2), MAPK3(3), PLA2G4A(9), PLCB1(4), PRKCA(7), PTGS1(5), PTK2(8), RAF1(5), SRC(2), SYK(3), TBXAS1(4)	8641312	91	36	91	32	23	31	19	6	12	0	0.77	0.93
515	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	37	ARNTL(8), AZIN1(3), CBX3(3), CLOCK(6), CRY1(5), CRY2(2), DNAJA1(2), EIF4G2(6), ETV6(5), GFRA1(6), GSTM3(4), GSTP1(2), HERPUD1(2), HSPA8(7), IDI1(3), KLF9(3), MYF6(5), NCKAP1(6), NCOA4(6), NR1D2(1), PER1(9), PER2(6), PIGF(2), PPP1R3C(3), PPP2CB(2), PSMA4(1), SF3A3(5), SUMO3(2), TOB1(2), UGP2(5), VAPA(5), ZFR(9)	12857064	136	44	132	36	40	53	19	9	15	0	0.78	0.93
516	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(6), NR0B2(2), NR1H3(4), NR1H4(6), RXRA(1)	1914808	22	16	22	5	3	12	4	0	3	0	0.78	0.93
517	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(4), C1QB(2), C1R(9), C1S(5), C2(3), C3(18), C5(14), C6(13), C7(16), C8A(9), C8B(3), MASP1(9)	7206880	105	34	99	37	20	52	13	5	11	4	0.78	0.93
518	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACAA1(4), ACOX1(3), ACOX3(5), ELOVL2(6), ELOVL5(2), ELOVL6(2), FADS1(4), FADS2(1), HADHA(5), HSD17B12(3), PECR(4), SCD(6)	3856400	45	22	45	12	10	20	8	3	4	0	0.79	0.93
519	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(10), CD44(4), CSF1(3), FCGR3A(1), IL1B(2), IL6R(7), SELL(3), SPN(1), TGFB1(2), TGFB2(5), TNFRSF1A(4), TNFRSF1B(1), TNFRSF8(6), TNFSF8(1)	4773008	50	26	47	18	11	19	9	3	8	0	0.79	0.93
520	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	40	ABP1(5), AGMAT(3), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH4A1(1), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(9), ARG1(4), ARG2(3), ASL(2), CKM(2), CKMT1A(1), CKMT2(2), CPS1(19), DAO(3), GATM(4), GLUD1(3), GOT1(5), GOT2(3), MAOA(10), MAOB(5), NOS1(14), NOS3(6), OAT(6), ODC1(1), OTC(6), P4HA1(5), P4HA2(10), P4HA3(2), RARS(9), SMS(7)	14916952	183	50	178	67	49	76	21	14	19	4	0.79	0.93
521	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(5), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT5(2), FUT8(12), ST3GAL1(1), ST3GAL2(3), ST3GAL3(4), ST3GAL4(3)	2704192	41	20	37	11	14	18	7	0	2	0	0.79	0.93
522	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(15), COL4A2(5), COL4A3(19), COL4A4(17), COL4A5(19), COL4A6(28), SLC23A1(6), SLC23A2(4), SLC2A1(2), SLC2A3(8)	9232792	123	39	120	36	36	49	12	7	14	5	0.79	0.93
523	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	29	ACTR2(5), ACTR3(1), AKT1(3), ANGPTL2(4), DAG1(4), DGKA(9), ETFA(4), GCA(2), ITGA9(13), ITPKB(7), ITPR1(23), ITPR2(25), ITPR3(15), MAP2K1(2), MAPK1(2), MAPK3(3), NR1I3(5), PAK1(1), PDE3A(14), PDE3B(9), PI3(2), PIK3C2G(12), PIK3CD(9), PLDN(3), PSME1(1), RIPK3(2), RPS4X(1), SGCB(3), VASP(1)	16426280	185	53	183	75	43	75	32	4	29	2	0.80	0.94
524	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(6), IDI1(3), SQLE(4)	1173288	14	10	14	2	5	4	3	1	1	0	0.80	0.94
525	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(3), ACP2(1), ACP5(2), ACP6(3), ACPP(3), ACPT(5), ALPI(2), ALPL(3), ALPP(3), ALPPL2(2), CMBL(3), CYP3A4(9), CYP3A43(3), CYP3A5(4), CYP3A7(6), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), PON1(11), PON2(6), PON3(1)	6301928	84	31	82	26	20	26	18	7	13	0	0.80	0.94
526	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(11), ARHGAP5(18), ARHGDIB(1), CASP1(5), CASP10(8), CASP3(3), CASP9(2), CYCS(2), GZMB(2), JUN(1), PRF1(6)	4305032	59	23	57	12	15	19	9	3	11	2	0.80	0.94
527	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	20	CDK5(1), CDK5R1(2), CFL1(1), CHN1(2), LIMK1(6), MAP3K1(24), MYL2(1), MYLK(10), NCF2(4), PAK1(1), PDGFRA(19), PLD1(9), PPP1R12B(11), RAC1(1), RALBP1(4), RPS6KB1(2), TRIO(25), VAV1(10), WASF1(3)	11459088	136	43	131	42	37	48	14	9	24	4	0.80	0.94
528	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(5), ACTR3(1), ARPC1A(5), ARPC1B(3), ARPC3(1), ARPC4(1), CDC42(4), PAK1(1), PDGFRA(19), RAC1(1), WASL(7)	3549128	48	20	47	7	11	20	6	2	7	2	0.80	0.94
529	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	20	CRK(1), CXCL12(2), CXCR4(1), GNAI1(4), GNB1(1), MAP2K1(2), MAPK1(2), MAPK3(3), NFKB1(7), PIK3C2G(12), PLCG1(8), PRKCA(7), PTK2(8), PTK2B(13), PXN(4), RAF1(5), RELA(4)	8268816	84	36	83	36	22	31	16	6	9	0	0.81	0.94
530	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(6), SNAP25(7)	1192384	16	13	15	4	7	5	3	0	1	0	0.81	0.94
531	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(3), GBA3(7), GGT1(5), SHMT1(4), SHMT2(2)	2042776	21	15	21	9	4	11	2	0	4	0	0.81	0.94
532	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(10), AGT(7), AGTR1(1), AGTR2(7), BDKRB2(7), KNG1(7), NOS3(6), REN(1)	3176880	46	21	43	11	16	22	3	2	3	0	0.81	0.94
533	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(2), HLA-A(1), IL18(1), ITGB1(5), KLRC1(2), KLRC2(3), KLRC3(1), KLRC4(2), KLRD1(1), MAP2K1(2), MAPK3(3), PAK1(1), PTK2B(13), RAC1(1), SYK(3), VAV1(10)	5398464	51	28	51	18	15	19	7	4	6	0	0.81	0.94
534	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), TGDS(3), UGDH(2), UXS1(5)	1475600	12	11	12	7	3	4	3	1	1	0	0.81	0.94
535	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(17), AGT(7), AGTR1(1), AGTR2(7), CMA1(1), COL4A1(15), COL4A2(5), COL4A3(19), COL4A4(17), COL4A5(19), COL4A6(28), REN(1)	9366464	137	40	133	31	43	56	12	7	14	5	0.82	0.94
536	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(11), G6PD(3), GCLC(5), GCLM(2), GGT1(5), GPX3(2), GPX5(5), GSS(3), GSTA1(2), GSTA2(4), GSTA3(2), GSTA4(3), GSTM1(2), GSTM2(1), GSTM3(4), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(4), IDH1(3), IDH2(4), MGST1(4), MGST3(1), PGD(2)	6509008	77	33	75	27	22	28	10	11	4	2	0.82	0.94
537	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(11), BAD(2), BAK1(3), BAX(3), BCL10(2), BCL2L1(3), BCL2L11(5), BID(2), CASP8AP2(3), CASP9(2), CES1(11)	4133664	47	23	46	8	9	16	14	1	7	0	0.82	0.94
538	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(11), EIF2AK4(5), EIF2B5(4), EIF2S2(5), EIF2S3(5), EIF5(2), GSK3B(8), PPP1CA(3)	4211288	43	25	42	10	11	19	5	2	6	0	0.83	0.94
539	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(5), APOBEC1(7), APOBEC2(3), APOBEC3A(1), APOBEC3B(6), APOBEC3C(4), APOBEC3F(4), APOBEC3G(2), APOBEC4(4)	2687080	36	20	36	9	9	19	6	1	1	0	0.83	0.94
540	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(1), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH9A1(1), ALDOA(4), ALDOB(6), ALDOC(3), BPGM(1), DLAT(1), DLD(3), ENO1(4), ENO2(3), ENO3(3), FBP1(2), G6PC(5), GAPDH(2), GCK(3), GPI(5), HK1(9), HK2(5), HK3(8), LDHA(6), LDHB(2), LDHC(4), PDHA1(4), PDHA2(8), PDHB(3), PFKM(4), PFKP(6), PGAM1(1), PGK1(5), PGM1(5), PGM3(4), PKLR(5), PKM2(4)	17239968	193	54	191	67	54	73	25	12	29	0	0.83	0.94
541	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(1), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH9A1(1), ALDOA(4), ALDOB(6), ALDOC(3), BPGM(1), DLAT(1), DLD(3), ENO1(4), ENO2(3), ENO3(3), FBP1(2), G6PC(5), GAPDH(2), GCK(3), GPI(5), HK1(9), HK2(5), HK3(8), LDHA(6), LDHB(2), LDHC(4), PDHA1(4), PDHA2(8), PDHB(3), PFKM(4), PFKP(6), PGAM1(1), PGK1(5), PGM1(5), PGM3(4), PKLR(5), PKM2(4)	17239968	193	54	191	67	54	73	25	12	29	0	0.83	0.94
542	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	45	ADCY4(7), ADCY6(10), ADCY8(15), CACNA1A(15), GNAS(16), GNAT3(6), GNB1(1), GNG3(2), GRM4(12), ITPR3(15), KCNB1(11), PDE1A(10), PLCB2(7), PRKACA(4), PRKACG(7), PRKX(2), SCNN1A(2), SCNN1B(4), SCNN1G(8), TAS1R1(7), TAS1R2(8), TAS2R1(4), TAS2R10(5), TAS2R13(2), TAS2R14(5), TAS2R16(2), TAS2R3(2), TAS2R38(3), TAS2R39(7), TAS2R4(2), TAS2R40(4), TAS2R41(2), TAS2R42(3), TAS2R46(2), TAS2R5(3), TAS2R50(2), TAS2R60(5), TAS2R7(2), TAS2R8(5)	19672600	229	54	223	86	67	96	30	12	24	0	0.83	0.94
543	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(4), CFL1(1), GNAS(16), GNB1(1), LIMK1(6), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(1), NOX1(10), PIK3C2G(12), PLCB1(4), PPP1R12B(11), PRKCA(7), PTK2(8), RAF1(5), ROCK2(10)	9087960	103	37	100	30	29	36	19	7	12	0	0.84	0.95
544	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(5), CALCR(4), CALCRL(7), CD97(7), CRHR1(2), CRHR2(1), ELTD1(10), EMR1(19), EMR2(3), GHRHR(1), GIPR(3), GLP1R(5), GLP2R(8), GPR64(8), LPHN1(11), LPHN2(19), LPHN3(14), SCTR(3), VIPR1(2)	9781120	132	39	127	49	30	65	12	8	15	2	0.84	0.95
545	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPN1(2), CAPN2(5), CAPNS1(1), CAPNS2(3), CXCR3(5), EGF(17), EGFR(10), ITGA1(13), ITGB1(5), MAPK1(2), MAPK3(3), MYL2(1), MYLK(10), PRKACG(7), PRKAR1A(4), PRKAR1B(4), PRKAR2A(3), PRKAR2B(3), PTK2(8), PXN(4), TLN1(20)	11861344	133	43	131	41	33	57	20	5	18	0	0.84	0.95
546	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(7), AMT(2), ATIC(6), DHFR(3), GART(6), MTHFD1(4), MTHFD1L(11), MTHFD2(2), MTHFR(5), MTR(7), SHMT1(4), SHMT2(2)	6685832	59	30	57	23	13	30	6	3	7	0	0.84	0.95
547	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	62	ACSS1(3), ACSS2(7), ACYP1(2), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(1), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH7A1(2), ALDH9A1(1), ALDOA(4), ALDOB(6), ALDOC(3), BPGM(1), DLAT(1), DLD(3), ENO1(4), ENO2(3), ENO3(3), FBP1(2), G6PC(5), G6PC2(4), GAPDH(2), GAPDHS(8), GCK(3), GPI(5), HK1(9), HK2(5), HK3(8), LDHA(6), LDHAL6A(7), LDHAL6B(2), LDHB(2), LDHC(4), PDHA1(4), PDHA2(8), PDHB(3), PFKM(4), PFKP(6), PGAM1(1), PGAM2(1), PGK1(5), PGK2(2), PGM1(5), PGM3(4), PKLR(5), PKM2(4)	19935232	215	56	212	76	64	78	29	15	29	0	0.84	0.95
548	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	21	NRF1(5), TAX1BP3(1), UBE2A(3), UBE2B(3), UBE2C(1), UBE2D2(2), UBE2D3(2), UBE2E1(2), UBE2G1(2), UBE2H(1), UBE2J1(1), UBE2L3(2), UBE2L6(1), UBE2N(4), UBE3A(11)	3336344	41	21	41	16	9	17	9	1	5	0	0.85	0.95
549	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(11), CD2(4), CD33(6), CD5(5), IFNB1(2), IFNG(5), IL10(2), IL12A(5), IL12B(2), IL5(1), ITGAX(7), TLR2(11), TLR4(13), TLR7(12), TLR9(5)	6853480	91	32	89	32	27	36	13	4	9	2	0.86	0.96
550	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(3), AKT2(4), AKT3(7), BCR(4), BTK(4), CD19(3), CDKN2A(1), DAPP1(7), FLOT2(1), GAB1(5), ITPR1(23), ITPR2(25), ITPR3(15), LYN(6), NR0B2(2), PDK1(2), PHF11(3), PLCG2(23), PPP1R13B(5), PREX1(17), PTPRC(11), RPS6KA1(1), RPS6KA2(14), RPS6KA3(15), RPS6KB1(2), SAG(4), SYK(3), TEC(5), VAV1(10)	18815016	225	60	221	88	60	92	29	11	31	2	0.86	0.96
551	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CYP2C19(5), CYP2C9(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), ECHS1(2), EHHADH(4), ESCO1(8), ESCO2(5), HADHA(5), NAT6(1), PNPLA3(6), SH3GLB1(6), YOD1(2)	11057576	79	36	78	29	25	28	10	6	10	0	0.86	0.97
552	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	59	ATM(42), CCNA1(3), CCNB1(7), CCND2(7), CCND3(3), CCNE2(5), CCNG2(2), CCNH(3), CDC25A(7), CDK2(2), CDK4(3), CDK7(4), CDKN1A(1), CDKN2A(1), CDKN2C(2), CDKN2D(1), CREB3L1(3), CREB3L3(7), CREB3L4(5), E2F1(6), E2F2(2), E2F3(3), E2F4(2), E2F6(1), GBA2(9), MCM2(4), MCM3(8), MCM4(6), MCM5(7), MCM6(4), MCM7(3), MDM2(3), MYC(6), NACA(17), PCNA(2), POLA2(1), POLE2(2), PRIM1(2), RBL1(13), RPA1(5), RPA2(2), RPA3(3), TFDP2(5), TNXB(16), WEE1(1)	26195000	241	62	235	71	58	98	32	16	33	4	0.87	0.97
553	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(4), ALDOB(6), ALDOC(3), FBP1(2), G6PD(3), GPI(5), H6PD(4), PFKM(4), PFKP(6), PGD(2), PGLS(1), PGM1(5), PGM3(4), PRPS1(3), PRPS1L1(2), PRPS2(6), RPE(2), RPIA(7), TAL1(1), TALDO1(3), TKT(4)	7175384	77	32	75	30	23	31	12	4	7	0	0.88	0.98
554	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(1), EPO(1), EPOR(3), GRIN1(3), HIF1A(12), JAK2(14), NFKB1(7), NFKBIA(2), RELA(4), SOD2(3)	4406960	52	22	52	17	11	17	12	3	5	4	0.88	0.98
555	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	CASP3(3), CFL1(1), CFLAR(5), PDE6D(1)	917848	10	8	10	3	2	4	2	1	1	0	0.88	0.98
556	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(5), FUT1(3), FUT2(1), FUT9(7), GCNT2(10), ST8SIA1(1)	2206208	27	17	27	6	7	14	4	2	0	0	0.88	0.98
557	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	15	ALOX12(5), ALOX15(7), ALOX15B(5), ALOX5(6), ALOX5AP(2), GGT1(5), LTA4H(4), PLA2G6(7), PTGDS(4), PTGES(2), PTGIS(6), PTGS1(5), PTGS2(6), TBXAS1(4)	4815168	68	26	67	16	20	31	9	3	5	0	0.89	0.98
558	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(3), ARFGAP1(2), ARFGAP3(3), ARFGEF2(24), CLTB(5), COPA(11), GBF1(10), GPLD1(7), KDELR1(1), KDELR3(3)	5715408	69	27	68	20	9	35	11	5	7	2	0.89	0.98
559	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), ECHS1(2), EHHADH(4), HADHA(5), SDS(1)	4213768	37	21	36	21	12	11	4	6	4	0	0.90	0.98
560	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(6), HLCS(3), SPCS3(2)	1099880	11	8	11	8	5	1	4	0	1	0	0.90	0.98
561	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(4), GLB1(4), GNS(1), GUSB(4), HEXA(1), HEXB(3), IDS(5), LCT(24), NAGLU(2)	4815168	48	25	48	23	11	22	6	5	4	0	0.90	0.98
562	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(3), ALPP(3), ALPPL2(2), DHFR(3), FPGS(3), GCH1(1), GGH(2)	2095352	19	15	19	9	4	10	2	2	1	0	0.91	0.98
563	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(3), IL22RA1(2), IL22RA2(1), JAK1(16), JAK2(14), JAK3(5), STAT1(12), STAT3(8), STAT5A(2), STAT5B(3), TYK2(4)	6542736	70	29	69	37	10	34	10	3	9	4	0.91	0.98
564	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(3)	597184	3	3	3	1	0	1	1	0	1	0	0.91	0.98
565	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1)	4730104	45	22	44	11	15	14	8	2	6	0	0.91	0.98
566	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(12), ABCC2(23), ABCG2(8), BCHE(13), CES1(11), CES2(2), CYP3A4(9), CYP3A5(4), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2)	8482344	116	34	112	33	28	46	21	11	8	2	0.91	0.98
567	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(14), CD38(5), ENPP1(8), ENPP3(14), NADSYN1(6), NMNAT1(3), NMNAT2(2), NNMT(6), NNT(6), NT5C(1), NT5E(5), NT5M(3)	5208248	73	27	71	12	15	32	16	7	3	0	0.92	0.98
568	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), GUSB(4), RPE(2), UCHL1(3), UCHL3(1), UGDH(2), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2B15(8), UGT2B4(7)	5888760	62	27	60	14	24	21	8	4	5	0	0.92	0.98
569	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(3), ALDOA(4), ALDOB(6), ALDOC(3)	1435176	16	11	15	4	3	7	3	1	2	0	0.92	0.98
570	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(3), BLVRB(1), CP(11), CPOX(4), EPRS(7), FECH(4), GUSB(4), HCCS(1), HMBS(5), HMOX1(3), HMOX2(3), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2B15(8), UGT2B4(7), UROD(1), UROS(3)	9482032	99	35	96	31	30	42	14	6	7	0	0.92	0.98
571	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	31	GTF2A1(3), GTF2A1L(2), GTF2B(3), GTF2E1(3), GTF2E2(2), GTF2F1(5), GTF2H1(6), GTF2H3(3), GTF2I(2), GTF2IRD1(6), STON1(1), TAF1(37), TAF10(1), TAF1L(30), TAF2(10), TAF4(8), TAF4B(4), TAF5(5), TAF5L(2), TAF6(6), TAF6L(4), TAF7(3), TAF7L(8), TAF9(2), TBPL1(4), TBPL2(4)	13185168	164	44	161	43	47	66	26	7	18	0	0.92	0.98
572	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(4), ACAA2(2), ACAT1(4), ACAT2(4), ECHS1(2), EHHADH(4), HADHA(5), HADHB(3), SDS(1)	2957400	29	17	29	12	7	11	7	3	1	0	0.92	0.98
573	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	17	APAF1(11), BAK1(3), BAX(3), BCL2L1(3), BID(2), BIK(1), BIRC2(10), BIRC3(2), CASP3(3), CASP6(3), CASP7(4), CASP9(2), CYCS(2), DFFB(3), DIABLO(2)	4342976	54	21	53	14	14	14	12	2	12	0	0.92	0.98
574	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(6), ALG10B(6), ALG11(4), ALG13(13), ALG14(2), ALG3(1), ALG5(2), ALG6(3), ALG8(5), ALG9(5), B4GALT1(2), B4GALT2(3), B4GALT3(6), DAD1(1), DDOST(3), DHDDS(4), DOLPP1(1), DPAGT1(2), DPM1(1), FUT8(12), GANAB(8), MAN1A1(10), MAN1A2(5), MAN1B1(3), MAN1C1(6), MAN2A1(14), MGAT1(2), MGAT2(4), MGAT3(3), MGAT4A(3), MGAT4B(5), MGAT5(7), MGAT5B(6), RFT1(4), RPN1(2), RPN2(5), ST6GAL1(6), STT3B(3)	14900832	179	50	166	47	45	74	33	6	19	2	0.92	0.98
575	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	78	AGL(15), AMY2A(4), AMY2B(9), ASCC3(25), ATP13A2(4), DDX18(10), DDX19A(1), DDX23(8), DDX4(13), DDX41(1), DDX47(4), DDX50(8), DDX52(5), DDX54(6), DDX55(5), DDX56(4), DHX58(5), ENPP1(8), ENPP3(14), ENTPD7(6), ERCC2(1), ERCC3(8), G6PC(5), G6PC2(4), GAA(4), GANC(13), GBA(3), GBA3(7), GBE1(4), GCK(3), GPI(5), GUSB(4), GYS1(9), GYS2(14), HK1(9), HK2(5), HK3(8), IFIH1(3), LYZL1(1), MGAM(36), NUDT5(1), NUDT8(1), PGM1(5), PGM3(4), PYGB(9), PYGL(6), PYGM(4), RAD54B(12), RAD54L(3), RUVBL2(4), SETX(29), SKIV2L2(15), SMARCA2(18), SMARCA5(14), TREH(2), UGDH(2), UGP2(5), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3), UXS1(5)	42397584	546	81	527	149	144	192	102	36	65	7	0.92	0.98
576	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(5), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH3B2(5), ALDH9A1(1), AOC2(6), AOC3(9), ASPA(4), CNDP1(4), DDC(9), HAL(4), HARS(3), HDC(6), HNMT(4), MAOA(10), MAOB(5), PRPS1(3), PRPS2(6)	8900720	108	32	104	37	31	35	15	9	18	0	0.92	0.98
577	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(5), IARS(7), LARS(16), LARS2(7), PDHA1(4), PDHA2(8), PDHB(3)	3696192	50	21	49	9	9	21	6	4	10	0	0.92	0.98
578	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(4), ACAT2(4), ACYP1(2), ECHS1(2), EHHADH(4), GCDH(5), HADHA(5), SDHB(1), SDS(1)	2745856	28	17	28	14	5	13	5	3	2	0	0.93	0.98
579	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(7), CYCS(2), GPD2(3), NDUFA1(1), SDHA(10), SDHB(1), SDHC(4), UQCRC1(2)	2417256	30	16	30	7	5	17	5	2	1	0	0.93	0.98
580	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(9), KHK(1), LCT(24), MPI(3), PGM1(5), PYGL(6), PYGM(4), TREH(2)	4851624	54	22	54	29	8	23	10	6	7	0	0.93	0.98
581	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	61	ACHE(3), AGPAT2(1), AGPAT3(4), AGPAT4(3), AGPAT6(6), CDS1(4), CHAT(1), CHKA(7), CHPT1(1), DGKA(9), DGKB(14), DGKD(11), DGKE(3), DGKG(10), DGKH(9), DGKI(16), DGKZ(8), ESCO1(8), ESCO2(5), ETNK1(8), ETNK2(1), GNPAT(6), GPAM(6), GPD1(2), GPD1L(3), GPD2(3), LCAT(2), LYPLA1(1), LYPLA2(4), NAT6(1), PCYT1A(1), PCYT1B(3), PEMT(1), PISD(2), PLA2G12A(1), PLA2G12B(2), PLA2G2D(2), PLA2G2E(3), PLA2G2F(2), PLA2G3(3), PLA2G4A(9), PLA2G6(7), PLD1(9), PLD2(7), PNPLA3(6), PPAP2A(4), PPAP2B(2), PTDSS1(5), SH3GLB1(6)	22378280	235	60	234	79	62	93	34	13	33	0	0.93	0.98
582	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(2), B4GALT1(2), B4GALT2(3), B4GALT3(6), B4GALT5(2), DDOST(3), DPAGT1(2), DPM1(1), FUT8(12), MAN1A1(10), MAN1B1(3), MGAT1(2), MGAT2(4), MGAT3(3), MGAT4A(3), MGAT4B(5), MGAT5(7), RPN1(2), RPN2(5), ST6GAL1(6)	6804624	84	30	77	21	26	32	16	2	8	0	0.93	0.98
583	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(2), EHHADH(4), HADHA(5), SDS(1)	1679952	13	10	13	14	3	4	3	3	0	0	0.93	0.98
584	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(6), GGPS1(2), IDI1(3), IDI2(1), SQLE(4)	1573808	17	11	17	5	6	6	3	1	1	0	0.93	0.98
585	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(24), DAXX(6), PAX3(4), PML(6), RARA(1), SIRT1(4), SP100(10), TNFRSF1A(4), TNFRSF1B(1)	5667792	60	26	59	19	14	26	10	1	9	0	0.93	0.98
586	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(4), FOS(2), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(3), MYC(6), NFKB1(7), NFKBIA(2), PLCB1(4), PRKCA(7), RAF1(5), RELA(4)	5586448	49	25	49	17	7	19	11	8	4	0	0.93	0.98
587	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1)	2784296	25	15	24	10	9	8	1	3	4	0	0.94	0.98
588	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1)	2784296	25	15	24	10	9	8	1	3	4	0	0.94	0.98
589	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(8), CSF1R(6), EGF(17), EGFR(10), GRB2(3), MET(9), PDGFRA(19), PRKCA(7), SH3GLB1(6), SH3GLB2(3), SH3KBP1(6), SRC(2)	7119584	96	31	93	35	21	37	20	5	11	2	0.94	0.98
590	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	CDK5(1), CDK5R1(2), DPM2(2), EGR1(6), KLK2(2), MAP2K1(2), MAPK1(2), MAPK3(3), NGFR(3), RAF1(5)	2731968	28	18	28	11	7	13	6	1	1	0	0.94	0.98
591	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(1), CHST11(7), CHST12(3), PAPSS1(5), PAPSS2(5), SULT1A1(4), SULT1A2(1), SULT1E1(9), SULT2A1(6), SULT2B1(2)	3294928	43	19	39	17	11	24	5	1	2	0	0.94	0.98
592	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(4), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB2(2), PSMB3(1), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(1), PSMC2(2), PSMD1(8), PSMD11(3), PSMD12(4), PSMD13(1), PSMD2(6), PSMD6(1)	5803696	53	25	50	21	11	20	8	2	12	0	0.95	0.99
593	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), CDK5R1(2), DAB1(4), FYN(6), LRP8(3), RELN(36), VLDLR(3)	5183200	55	25	53	19	17	19	10	2	5	2	0.95	0.99
594	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(3), SRP19(3), SRP54(7), SRP68(4), SRP72(6), SRP9(1), SRPR(9)	2741144	34	16	34	8	10	14	2	3	5	0	0.95	0.99
595	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	12	AKR1A1(1), ECHS1(2), EHHADH(4), HADH(1), HADHA(5), HSD17B10(2), HSD17B4(8), NTAN1(3), SIRT1(4), SIRT2(4), SIRT5(1), VNN2(8)	4042400	43	20	41	18	7	21	9	4	2	0	0.95	0.99
596	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(4), ACAT2(4), ACOT11(4), ACYP1(2), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), ECHS1(2), EHHADH(4), ESCO1(8), ESCO2(5), GCDH(5), HADHA(5), NAT6(1), PNPLA3(6), SH3GLB1(6), YOD1(2)	9325296	72	34	72	24	17	29	12	4	10	0	0.95	0.99
597	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), GUSB(4), RPE(2), UGDH(2), UGP2(5), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3), XYLB(5)	9133840	125	33	118	26	42	48	19	7	9	0	0.96	0.99
598	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), AKR1C1(3), AKR1C2(3), AKR1C3(2), AKR1C4(5), ALDH3A1(2), ALDH3B2(5), CYP1A1(9), CYP1A2(5), CYP1B1(1), CYP2B6(11), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(4), CYP2E1(1), CYP2F1(3), CYP2S1(6), CYP3A4(9), CYP3A43(3), CYP3A5(4), CYP3A7(6), DHDH(2), EPHX1(1), GSTA1(2), GSTA2(4), GSTA3(2), GSTA4(3), GSTA5(3), GSTK1(3), GSTM1(2), GSTM2(1), GSTM3(4), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(4), MGST1(4), MGST3(1), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3)	20205800	274	56	265	64	80	108	45	16	25	0	0.97	0.99
599	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(14), BST1(1), CD38(5), ENPP1(8), ENPP3(14), NADK(4), NADSYN1(6), NMNAT1(3), NMNAT2(2), NNMT(6), NNT(6), NT5C(1), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(8), NT5E(5), NT5M(3), NUDT12(2)	7702136	99	31	96	27	23	40	21	11	4	0	0.97	0.99
600	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(6), AASDH(7), AASDHPPT(4), AASS(6), ACAT1(4), ACAT2(4), ALDH1A1(6), ALDH1A2(8), ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH9A1(1), ATP6V0C(1), DLST(8), DOT1L(5), ECHS1(2), EHHADH(4), EHMT2(1), GCDH(5), HADHA(5), PLOD1(3), PLOD2(13), PLOD3(6), SDS(1), SHMT1(4), SHMT2(2), TMLHE(4)	12466216	120	40	118	43	34	39	20	10	15	2	0.97	0.99
601	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(1), CHKA(7), PCYT1A(1), PDHA1(4), PDHA2(8), PEMT(1)	2469336	25	14	25	10	9	5	5	2	4	0	0.97	0.99
602	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(5), BCAT2(3), IARS(7), IARS2(13), ILVBL(7), LARS(16), LARS2(7), PDHA1(4), PDHA2(8), PDHB(3), VARS(4)	6785032	77	27	75	18	15	37	7	6	12	0	0.97	0.99
603	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(5), CYP2E1(1), NR1I3(5), PTGS1(5), PTGS2(6)	1944320	22	13	22	6	7	8	3	1	3	0	0.98	1.00
604	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(4), ABP1(5), AOC2(6), AOC3(9), CES1(11), DDHD1(10), ESCO1(8), ESCO2(5), LIPA(5), NAT6(1), PLA1A(3), PNPLA3(6), PPME1(1), PRDX6(2), SH3GLB1(6)	9327776	82	31	78	32	23	23	17	5	12	2	0.98	1.00
605	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(8), CYP51A1(3), DHCR24(5), DHCR7(2), FDFT1(1), FDPS(6), GGCX(7), GGPS1(2), HMGCR(9), HSD17B7(3), IDI1(3), IDI2(1), MVD(3), MVK(3), NQO1(3), NSDHL(9), PMVK(2), SC5DL(2), SQLE(4), TM7SF2(1), VKORC1(1)	6542488	78	24	77	40	28	29	10	4	7	0	0.98	1.00
606	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(3), ALAS1(5), ALAS2(10), BLVRB(1), COX10(1), COX15(3), CP(11), CPOX(4), EARS2(3), EPRS(7), FECH(4), FTH1(2), FTMT(5), GUSB(4), HCCS(1), HMBS(5), HMOX1(3), HMOX2(3), MMAB(1), UGT1A1(4), UGT1A10(7), UGT1A3(1), UGT1A4(4), UGT1A5(5), UGT1A6(2), UGT1A7(6), UGT1A8(3), UGT1A9(2), UGT2A1(8), UGT2A3(2), UGT2B10(14), UGT2B11(13), UGT2B15(8), UGT2B17(4), UGT2B28(13), UGT2B4(7), UGT2B7(3), UROD(1), UROS(3)	14519408	186	42	178	51	55	79	29	11	12	0	0.98	1.00
607	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL5(2), CCR3(4), IL5(1)	1124184	7	6	7	1	0	4	2	0	1	0	0.98	1.00
608	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(5), PAPSS2(5), SULT1A2(1), SULT1E1(9), SULT2A1(6)	2261760	27	13	24	10	6	15	3	1	2	0	0.99	1.00
609	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(16), EGF(17), EGFR(10), RAB5A(1), TF(12), TFRC(3)	4653968	59	22	57	15	13	24	10	2	10	0	0.99	1.00
610	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(4), ACAD9(8), ADH1A(2), ADH1B(4), ADH1C(7), ADH4(4), ADH6(7), ADH7(4), ADHFE1(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), ESCO1(8), ESCO2(5), NAT6(1), PNPLA3(6), SH3GLB1(6)	9099864	84	28	84	18	22	31	15	0	14	2	0.99	1.00
611	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(3), B3GALT5(4), FUT1(3), FUT2(1), FUT9(7), GBGT1(5), GLA(2), HEXA(1), HEXB(3), NAGA(2), ST3GAL1(1), ST3GAL2(3), ST8SIA1(1)	3688256	36	18	34	15	10	16	5	2	3	0	0.99	1.00
612	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	39	ACTR2(5), ACTR3(1), AKT1(3), AKT2(4), AKT3(7), ANGPTL2(4), ARHGAP1(2), ARHGAP4(8), ARHGEF11(18), BTK(4), CDC42(4), CFL1(1), CFL2(7), GDI1(4), GDI2(1), ITPR1(23), ITPR2(25), ITPR3(15), LIMK1(6), MYLK(10), MYLK2(6), PAK1(1), PAK2(3), PAK3(13), PAK6(2), PAK7(6), PDK1(2), PIK3CD(9), PIK3CG(18), PPP1R13B(5), RACGAP1(7), RHO(3), ROCK1(15), ROCK2(10), RPS4X(1), SAG(4), WASF1(3), WASL(7)	22786736	267	58	262	101	84	104	31	13	31	4	0.99	1.00
613	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(5), DHRSX(1), ESCO1(8), ESCO2(5), NAT6(1), PNPLA3(6), SH3GLB1(6)	6008296	40	22	40	9	11	16	6	0	7	0	1.00	1.00
614	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(6), ALDH2(1), ALDH3A1(2), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), UGDH(2)	2853240	15	12	14	7	7	4	0	2	2	0	1.00	1.00
615	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(3), FUT2(1), FUT9(7), GBGT1(5), GLA(2), HEXA(1), HEXB(3), NAGA(2), ST3GAL1(1), ST3GAL2(3), ST3GAL4(3), ST8SIA1(1)	3458360	32	16	32	13	9	14	7	2	0	0	1.00	1.00
616	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(2), ALPL(3), ALPP(3), ALPPL2(2), ASCC3(25), ATP13A2(4), DDX18(10), DDX19A(1), DDX23(8), DDX4(13), DDX41(1), DDX47(4), DDX50(8), DDX52(5), DDX54(6), DDX55(5), DDX56(4), DHFR(3), DHX58(5), ENTPD7(6), ERCC2(1), ERCC3(8), FPGS(3), GCH1(1), GGH(2), IFIH1(3), NUDT5(1), NUDT8(1), PTS(1), RAD54B(12), RAD54L(3), RUVBL2(4), SETX(29), SKIV2L2(15), SMARCA2(18), SMARCA5(14)	22054640	234	51	223	66	57	84	45	16	25	7	1.00	1.00