Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.101 0.257 -9999.0 0.0 -0.623 82.0 82.0 IHH -0.014 0.093 -9999.0 0.0 -0.482 14.0 14.0 SHH Np/Cholesterol/GAS1 -0.057 0.141 -9999.0 0.0 -0.29 133.0 133.0 LRPAP1 0.016 0.026 -9999.0 0.0 -0.388 2.0 2.0 dorsoventral neural tube patterning 0.056 0.14 0.289 133.0 -9999.0 0.0 133.0 SMO/beta Arrestin2 -0.055 0.172 -9999.0 0.0 -0.514 37.0 37.0 SMO -0.066 0.18 -9999.0 0.0 -0.546 37.0 37.0 AKT1 -0.027 0.134 -9999.0 0.0 -0.515 21.0 21.0 ARRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.02 0.124 -9999.0 0.0 -0.382 50.0 50.0 ADRBK1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.065 0.178 -9999.0 0.0 -0.537 37.0 37.0 STIL -0.052 0.148 -9999.0 0.0 -0.372 52.0 52.0 DHH N/PTCH2 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.028 0.126 -9999.0 0.0 -0.368 24.0 24.0 PIK3CA 0.016 0.029 -9999.0 0.0 -0.343 3.0 3.0 DHH 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.121 0.312 -9999.0 0.0 -0.834 66.0 66.0 determination of left/right symmetry -0.065 0.178 -9999.0 0.0 -0.537 37.0 37.0 PIK3R1 -0.009 0.11 -9999.0 0.0 -0.416 33.0 33.0 skeletal system development -0.119 0.308 -9999.0 0.0 -0.822 66.0 66.0 IHH N/Hhip 0.004 0.068 -9999.0 0.0 -0.29 22.0 22.0 DHH N/Hhip 0.021 0.037 -9999.0 0.0 -0.369 3.0 3.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.065 0.178 -9999.0 0.0 -0.537 37.0 37.0 pancreas development 0.011 0.052 -9999.0 0.0 -0.326 11.0 11.0 HHAT -0.045 0.172 -9999.0 0.0 -0.509 63.0 63.0 PI3K 0.005 0.082 -9999.0 0.0 -0.369 21.0 21.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.072 0.194 -9999.0 0.0 -0.467 98.0 98.0 somite specification -0.065 0.178 -9999.0 0.0 -0.537 37.0 37.0 SHH Np/Cholesterol/PTCH1 -0.049 0.143 -9999.0 0.0 -0.367 44.0 44.0 SHH Np/Cholesterol/PTCH2 -0.007 0.098 -9999.0 0.0 -0.276 61.0 61.0 SHH Np/Cholesterol/Megalin -0.102 0.182 -9999.0 0.0 -0.334 181.0 181.0 SHH -0.021 0.126 -9999.0 0.0 -0.369 61.0 61.0 catabolic process -0.042 0.142 -9999.0 0.0 -0.42 24.0 24.0 SMO/Vitamin D3 -0.061 0.167 -9999.0 0.0 -0.455 40.0 40.0 SHH Np/Cholesterol/Hhip -0.01 0.101 -9999.0 0.0 -0.278 64.0 64.0 LRP2 -0.156 0.245 -9999.0 0.0 -0.483 183.0 183.0 receptor-mediated endocytosis -0.12 0.198 -9999.0 0.0 -0.49 74.0 74.0 SHH Np/Cholesterol/BOC -0.027 0.116 -9999.0 0.0 -0.283 85.0 85.0 SHH Np/Cholesterol/CDO -0.019 0.112 -9999.0 0.0 -0.287 74.0 74.0 mesenchymal cell differentiation 0.011 0.1 0.276 64.0 -9999.0 0.0 64.0 mol:Vitamin D3 -0.047 0.145 -9999.0 0.0 -0.368 44.0 44.0 IHH N/PTCH2 0.01 0.055 -9999.0 0.0 -0.322 11.0 11.0 CDON -0.004 0.099 -9999.0 0.0 -0.412 27.0 27.0 IHH N/PTCH1 -0.04 0.145 -9999.0 0.0 -0.423 24.0 24.0 Megalin/LRPAP1 -0.101 0.181 -9999.0 0.0 -0.371 158.0 158.0 PTCH2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.017 0.097 -9999.0 0.0 -0.284 61.0 61.0 PTCH1 -0.043 0.143 -9999.0 0.0 -0.421 24.0 24.0 HHIP 0.011 0.052 -9999.0 0.0 -0.327 11.0 11.0