E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.07 0.164 -9999.0 0.0 -0.336 129.0 129.0 KLHL20 -0.025 0.09 0.21 2.0 -0.227 24.0 26.0 CYFIP2 -0.006 0.13 -9999.0 0.0 -0.42 45.0 45.0 Rac1/GDP -0.035 0.117 0.269 4.0 -0.261 65.0 69.0 ENAH -0.065 0.162 -9999.0 0.0 -0.341 118.0 118.0 AP1M1 0.035 0.021 -9999.0 0.0 -0.42 1.0 1.0 RAP1B 0.033 0.03 -9999.0 0.0 -0.42 2.0 2.0 RAP1A 0.031 0.045 -9999.0 0.0 -0.42 5.0 5.0 CTNNB1 0.025 0.067 -9999.0 0.0 -0.42 11.0 11.0 CDC42/GTP -0.013 0.083 -9999.0 0.0 -0.195 57.0 57.0 ABI1/Sra1/Nap1 -0.046 0.054 -9999.0 0.0 -0.155 43.0 43.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.03 0.104 -9999.0 0.0 -0.233 58.0 58.0 RAPGEF1 -0.073 0.154 0.235 3.0 -0.359 83.0 86.0 CTNND1 0.034 0.022 -9999.0 0.0 -0.42 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.074 0.183 -9999.0 0.0 -0.35 146.0 146.0 CRK -0.069 0.162 -9999.0 0.0 -0.346 116.0 116.0 E-cadherin/gamma catenin/alpha catenin 0.018 0.098 -9999.0 0.0 -0.26 49.0 49.0 alphaE/beta7 Integrin 0.044 0.039 -9999.0 0.0 -0.3 5.0 5.0 IQGAP1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.035 0.021 -9999.0 0.0 -0.42 1.0 1.0 Rap1/GTP/I-afadin 0.047 0.064 -9999.0 0.0 -0.229 22.0 22.0 DLG1 -0.082 0.177 -9999.0 0.0 -0.342 150.0 150.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.031 0.056 -9999.0 0.0 -0.152 62.0 62.0 MLLT4 0.02 0.078 -9999.0 0.0 -0.42 15.0 15.0 ARF6/GTP/NME1/Tiam1 0.056 0.045 -9999.0 0.0 -0.235 9.0 9.0 PI3K -0.036 0.074 -9999.0 0.0 -0.194 58.0 58.0 ARF6 0.033 0.029 -9999.0 0.0 -0.42 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.004 0.104 -9999.0 0.0 -0.305 48.0 48.0 TIAM1 0.028 0.057 -9999.0 0.0 -0.42 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.03 0.097 -9999.0 0.0 -0.219 57.0 57.0 AKT1 -0.024 0.053 0.173 3.0 -0.169 5.0 8.0 PIK3R1 0.019 0.08 -9999.0 0.0 -0.42 16.0 16.0 CDH1 -0.012 0.129 -9999.0 0.0 -0.42 45.0 45.0 RhoA/GDP -0.036 0.121 0.268 4.0 -0.268 66.0 70.0 actin cytoskeleton organization -0.017 0.068 0.161 3.0 -0.165 24.0 27.0 CDC42/GDP -0.033 0.116 0.268 4.0 -0.261 64.0 68.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.01 0.077 -9999.0 0.0 -0.216 56.0 56.0 ITGB7 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.033 0.104 -9999.0 0.0 -0.233 57.0 57.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.018 0.087 -9999.0 0.0 -0.215 56.0 56.0 mol:GDP -0.054 0.122 0.268 4.0 -0.295 67.0 71.0 CDC42/GTP/IQGAP1 0.045 0.014 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.042 -9999.0 0.0 -0.42 4.0 4.0 p120 catenin/RhoA/GDP -0.031 0.127 0.281 3.0 -0.274 67.0 70.0 RAC1/GTP/IQGAP1 0.046 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.049 0.033 -9999.0 0.0 -0.3 4.0 4.0 RHOA 0.026 0.061 -9999.0 0.0 -0.42 9.0 9.0 CDC42 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.035 0.021 -9999.0 0.0 -0.42 1.0 1.0 positive regulation of S phase of mitotic cell cycle -0.03 0.077 0.146 1.0 -0.183 82.0 83.0 NME1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.08 0.175 -9999.0 0.0 -0.345 142.0 142.0 regulation of cell-cell adhesion -0.018 0.069 -9999.0 0.0 -0.173 60.0 60.0 WASF2 -0.016 0.042 0.115 2.0 -0.101 20.0 22.0 Rap1/GTP -0.015 0.091 0.248 1.0 -0.214 58.0 59.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.036 0.104 -9999.0 0.0 -0.227 53.0 53.0 CCND1 -0.038 0.094 0.166 1.0 -0.226 82.0 83.0 VAV2 -0.068 0.183 -9999.0 0.0 -0.409 75.0 75.0 RAP1/GDP -0.02 0.101 0.264 1.0 -0.227 60.0 61.0 adherens junction assembly -0.078 0.171 -9999.0 0.0 -0.335 144.0 144.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.033 0.036 -9999.0 0.0 -0.42 3.0 3.0 regulation of heterotypic cell-cell adhesion 0.028 0.106 -9999.0 0.0 -0.219 62.0 62.0 E-cadherin/beta catenin -0.024 0.102 -9999.0 0.0 -0.286 63.0 63.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.081 0.175 -9999.0 0.0 -0.345 144.0 144.0 PIK3CA 0.033 0.022 -9999.0 0.0 -0.42 1.0 1.0 Rac1/GTP -0.076 0.128 -9999.0 0.0 -0.349 40.0 40.0 E-cadherin/beta catenin/alpha catenin 0.02 0.102 -9999.0 0.0 -0.254 56.0 56.0 ITGAE 0.028 0.046 -9999.0 0.0 -0.42 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.076 0.187 -9999.0 0.0 -0.357 146.0 146.0