Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.04 0.194 -9999.0 0.0 -0.529 63.0 63.0 IHH 0.017 0.088 -9999.0 0.0 -0.284 24.0 24.0 SHH Np/Cholesterol/GAS1 -0.027 0.106 -9999.0 0.0 -0.235 101.0 101.0 LRPAP1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.027 0.105 0.233 101.0 -9999.0 0.0 101.0 SMO/beta Arrestin2 -0.022 0.17 -9999.0 0.0 -0.361 81.0 81.0 SMO -0.038 0.164 -9999.0 0.0 -0.364 88.0 88.0 AKT1 -0.015 0.157 -9999.0 0.0 -0.542 29.0 29.0 ARRB2 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.014 0.093 -9999.0 0.0 -0.42 22.0 22.0 ADRBK1 0.034 0.01 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.034 0.164 -9999.0 0.0 -0.359 88.0 88.0 STIL -0.006 0.135 0.195 77.0 -0.223 112.0 189.0 DHH N/PTCH2 0.052 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.001 0.12 -9999.0 0.0 -0.289 70.0 70.0 PIK3CA 0.033 0.022 -9999.0 0.0 -0.42 1.0 1.0 DHH 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.064 0.25 -9999.0 0.0 -0.661 67.0 67.0 determination of left/right symmetry -0.034 0.164 -9999.0 0.0 -0.359 88.0 88.0 PIK3R1 0.019 0.08 -9999.0 0.0 -0.42 16.0 16.0 skeletal system development -0.063 0.248 -9999.0 0.0 -0.654 67.0 67.0 IHH N/Hhip 0.035 0.065 -9999.0 0.0 -0.286 12.0 12.0 DHH N/Hhip 0.049 0.029 -9999.0 0.0 -0.3 3.0 3.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.034 0.164 -9999.0 0.0 -0.359 88.0 88.0 pancreas development 0.032 0.036 -9999.0 0.0 -0.419 3.0 3.0 HHAT -0.017 0.134 -9999.0 0.0 -0.42 50.0 50.0 PI3K 0.036 0.065 -9999.0 0.0 -0.3 17.0 17.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.03 0.158 -9999.0 0.0 -0.42 71.0 71.0 somite specification -0.034 0.164 -9999.0 0.0 -0.359 88.0 88.0 SHH Np/Cholesterol/PTCH1 -0.031 0.108 -9999.0 0.0 -0.234 103.0 103.0 SHH Np/Cholesterol/PTCH2 0.003 0.074 -9999.0 0.0 -0.23 44.0 44.0 SHH Np/Cholesterol/Megalin -0.055 0.138 -9999.0 0.0 -0.274 133.0 133.0 SHH -0.016 0.09 -9999.0 0.0 -0.3 46.0 46.0 catabolic process -0.025 0.124 -9999.0 0.0 -0.324 70.0 70.0 SMO/Vitamin D3 -0.019 0.153 0.199 44.0 -0.329 64.0 108.0 SHH Np/Cholesterol/Hhip 0.002 0.075 -9999.0 0.0 -0.23 45.0 45.0 LRP2 -0.096 0.205 -9999.0 0.0 -0.42 144.0 144.0 receptor-mediated endocytosis -0.071 0.175 -9999.0 0.0 -0.345 108.0 108.0 SHH Np/Cholesterol/BOC -0.007 0.085 -9999.0 0.0 -0.229 63.0 63.0 SHH Np/Cholesterol/CDO -0.007 0.083 -9999.0 0.0 -0.235 56.0 56.0 mesenchymal cell differentiation -0.001 0.074 0.229 45.0 -9999.0 0.0 45.0 mol:Vitamin D3 -0.007 0.133 0.2 64.0 -0.234 103.0 167.0 IHH N/PTCH2 0.037 0.06 -9999.0 0.0 -0.271 10.0 10.0 CDON 0.021 0.067 -9999.0 0.0 -0.42 11.0 11.0 IHH N/PTCH1 -0.005 0.132 -9999.0 0.0 -0.326 70.0 70.0 Megalin/LRPAP1 -0.049 0.158 -9999.0 0.0 -0.299 144.0 144.0 PTCH2 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.007 0.07 -9999.0 0.0 -0.227 46.0 46.0 PTCH1 -0.025 0.124 -9999.0 0.0 -0.325 70.0 70.0 HHIP 0.032 0.036 -9999.0 0.0 -0.42 3.0 3.0