Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.013 0.083 -9999.0 0.0 -0.214 68.0 68.0 epithelial cell differentiation 0.026 0.094 -9999.0 0.0 -0.217 57.0 57.0 CYFIP2 -0.006 0.13 -9999.0 0.0 -0.42 45.0 45.0 ENAH -0.028 0.075 0.296 2.0 -0.307 8.0 10.0 EGFR -0.015 0.134 -9999.0 0.0 -0.42 49.0 49.0 EPHA2 0.032 0.036 -9999.0 0.0 -0.42 3.0 3.0 MYO6 -0.036 0.077 0.182 7.0 -0.217 69.0 76.0 CTNNB1 0.025 0.067 -9999.0 0.0 -0.42 11.0 11.0 ABI1/Sra1/Nap1 0.041 0.09 -9999.0 0.0 -0.255 40.0 40.0 AQP5 -0.095 0.172 -9999.0 0.0 -0.452 84.0 84.0 CTNND1 0.034 0.022 -9999.0 0.0 -0.42 1.0 1.0 mol:PI-4-5-P2 -0.032 0.07 0.179 6.0 -0.211 58.0 64.0 regulation of calcium-dependent cell-cell adhesion -0.032 0.069 0.179 5.0 -0.207 60.0 65.0 EGF -0.069 0.186 -9999.0 0.0 -0.42 110.0 110.0 NCKAP1 0.035 0.021 -9999.0 0.0 -0.42 1.0 1.0 AQP3 -0.094 0.173 -9999.0 0.0 -0.453 84.0 84.0 cortical microtubule organization 0.026 0.094 -9999.0 0.0 -0.217 57.0 57.0 GO:0000145 -0.033 0.065 0.163 1.0 -0.202 58.0 59.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.031 0.097 -9999.0 0.0 -0.218 57.0 57.0 MLLT4 0.02 0.078 -9999.0 0.0 -0.42 15.0 15.0 ARF6/GDP -0.041 0.067 -9999.0 0.0 -0.22 54.0 54.0 ARF6 0.034 0.029 -9999.0 0.0 -0.42 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.053 0.072 -9999.0 0.0 -0.233 20.0 20.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.026 0.093 -9999.0 0.0 -0.346 17.0 17.0 PVRL2 0.026 0.064 -9999.0 0.0 -0.42 10.0 10.0 ZYX -0.034 0.074 0.182 8.0 -0.213 64.0 72.0 ARF6/GTP 0.059 0.077 -9999.0 0.0 -0.238 20.0 20.0 CDH1 -0.011 0.129 -9999.0 0.0 -0.42 45.0 45.0 EGFR/EGFR/EGF/EGF -0.057 0.138 -9999.0 0.0 -0.223 191.0 191.0 RhoA/GDP 0.023 0.099 -9999.0 0.0 -0.216 64.0 64.0 actin cytoskeleton organization -0.04 0.074 -9999.0 0.0 -0.214 66.0 66.0 IGF-1R heterotetramer -0.042 0.169 -9999.0 0.0 -0.419 84.0 84.0 GIT1 0.034 0.022 -9999.0 0.0 -0.42 1.0 1.0 IGF1R -0.042 0.169 -9999.0 0.0 -0.42 84.0 84.0 IGF1 -0.038 0.164 -9999.0 0.0 -0.42 78.0 78.0 DIAPH1 0.002 0.204 -9999.0 0.0 -0.588 36.0 36.0 Wnt receptor signaling pathway -0.026 0.094 0.217 57.0 -9999.0 0.0 57.0 RHOA 0.026 0.061 -9999.0 0.0 -0.42 9.0 9.0 RhoA/GTP -0.043 0.068 -9999.0 0.0 -0.219 60.0 60.0 CTNNA1 0.035 0.021 -9999.0 0.0 -0.42 1.0 1.0 VCL -0.041 0.075 -9999.0 0.0 -0.218 67.0 67.0 EFNA1 0.014 0.08 -9999.0 0.0 -0.42 16.0 16.0 LPP -0.038 0.071 0.17 8.0 -0.209 60.0 68.0 Ephrin A1/EPHA2 0.01 0.092 -9999.0 0.0 -0.221 57.0 57.0 SEC6/SEC8 -0.048 0.069 -9999.0 0.0 -0.207 75.0 75.0 MGAT3 -0.032 0.07 0.181 5.0 -0.21 60.0 65.0 HGF/MET 0.016 0.093 -9999.0 0.0 -0.206 66.0 66.0 HGF 0.028 0.057 -9999.0 0.0 -0.42 8.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.013 0.084 -9999.0 0.0 -0.215 68.0 68.0 actin cable formation 0.016 0.108 0.262 12.0 -0.308 8.0 20.0 KIAA1543 -0.037 0.07 0.169 7.0 -0.215 58.0 65.0 KIFC3 -0.031 0.068 0.181 6.0 -0.212 52.0 58.0 NCK1 0.034 0.021 -9999.0 0.0 -0.42 1.0 1.0 EXOC3 0.036 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.034 0.075 0.182 8.0 -0.213 65.0 73.0 NCK1/GIT1 0.049 0.025 -9999.0 0.0 -0.294 2.0 2.0 mol:GDP 0.026 0.094 -9999.0 0.0 -0.217 57.0 57.0 EXOC4 0.034 0.021 -9999.0 0.0 -0.42 1.0 1.0 STX4 -0.034 0.062 -9999.0 0.0 -0.207 57.0 57.0 PIP5K1C -0.032 0.071 0.181 6.0 -0.214 58.0 64.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.009 0.102 0.304 5.0 -0.324 7.0 12.0 adherens junction assembly -0.044 0.116 0.266 1.0 -0.463 16.0 17.0 IGF-1R heterotetramer/IGF1 -0.055 0.148 -9999.0 0.0 -0.243 175.0 175.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.076 -9999.0 0.0 -0.299 24.0 24.0 MET 0.03 0.041 -9999.0 0.0 -0.42 4.0 4.0 PLEKHA7 -0.031 0.07 0.182 8.0 -0.211 58.0 66.0 mol:GTP 0.051 0.071 -9999.0 0.0 -0.232 20.0 20.0 establishment of epithelial cell apical/basal polarity -0.044 0.072 0.14 13.0 -0.204 64.0 77.0 cortical actin cytoskeleton stabilization -0.013 0.083 -9999.0 0.0 -0.214 68.0 68.0 regulation of cell-cell adhesion -0.04 0.074 -9999.0 0.0 -0.214 66.0 66.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.013 0.084 -9999.0 0.0 -0.215 68.0 68.0