Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.001 0.103 -9999.0 0.0 -0.589 2.0 2.0 epithelial cell differentiation 0.001 0.105 -9999.0 0.0 -0.533 1.0 1.0 CYFIP2 -0.016 0.139 -9999.0 0.0 -0.597 12.0 12.0 ENAH 0.012 0.128 -9999.0 0.0 -0.415 7.0 7.0 EGFR -0.01 0.122 -9999.0 0.0 -0.544 11.0 11.0 EPHA2 -0.023 0.143 -9999.0 0.0 -0.516 17.0 17.0 MYO6 0.003 0.109 -9999.0 0.0 -0.507 1.0 1.0 CTNNB1 -0.021 0.14 -9999.0 0.0 -0.52 16.0 16.0 ABI1/Sra1/Nap1 0.0 0.112 -9999.0 0.0 -0.388 13.0 13.0 AQP5 -0.047 0.107 -9999.0 0.0 -0.561 4.0 4.0 CTNND1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.01 0.099 -9999.0 0.0 -0.497 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.054 0.148 -9999.0 0.0 -0.5 4.0 4.0 EGF -0.194 0.267 -9999.0 0.0 -0.521 88.0 88.0 NCKAP1 -0.005 0.106 -9999.0 0.0 -0.495 10.0 10.0 AQP3 -0.069 0.137 -9999.0 0.0 -0.48 15.0 15.0 cortical microtubule organization 0.001 0.105 -9999.0 0.0 -0.533 1.0 1.0 GO:0000145 0.009 0.095 -9999.0 0.0 -0.474 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.004 0.107 -9999.0 0.0 -0.54 1.0 1.0 MLLT4 -0.002 0.109 -9999.0 0.0 -0.609 7.0 7.0 ARF6/GDP -0.056 0.127 -9999.0 0.0 -0.523 9.0 9.0 ARF6 0.003 0.093 -9999.0 0.0 -0.609 5.0 5.0 Ephrin A1/EPHA2/NCK1/GIT1 0.003 0.119 -9999.0 0.0 -0.369 15.0 15.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.012 0.107 -9999.0 0.0 -0.423 3.0 3.0 PVRL2 0.01 0.062 -9999.0 0.0 -0.514 3.0 3.0 ZYX 0.007 0.105 -9999.0 0.0 -0.507 1.0 1.0 ARF6/GTP 0.003 0.127 -9999.0 0.0 -0.544 5.0 5.0 CDH1 -0.013 0.135 -9999.0 0.0 -0.609 11.0 11.0 EGFR/EGFR/EGF/EGF -0.128 0.157 -9999.0 0.0 -0.496 19.0 19.0 RhoA/GDP -0.03 0.086 -9999.0 0.0 -0.5 1.0 1.0 actin cytoskeleton organization 0.01 0.106 -9999.0 0.0 -0.475 1.0 1.0 IGF-1R heterotetramer 0.012 0.053 -9999.0 0.0 -0.537 2.0 2.0 GIT1 0.015 0.032 -9999.0 0.0 -0.466 1.0 1.0 IGF1R 0.012 0.053 -9999.0 0.0 -0.537 2.0 2.0 IGF1 -0.019 0.132 -9999.0 0.0 -0.493 16.0 16.0 DIAPH1 -0.038 0.147 -9999.0 0.0 -0.618 13.0 13.0 Wnt receptor signaling pathway -0.001 0.105 0.533 1.0 -9999.0 0.0 1.0 RHOA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.051 0.12 -9999.0 0.0 -0.53 7.0 7.0 CTNNA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.009 0.108 -9999.0 0.0 -0.489 1.0 1.0 EFNA1 -0.002 0.104 -9999.0 0.0 -0.537 8.0 8.0 LPP 0.015 0.1 -9999.0 0.0 -0.475 1.0 1.0 Ephrin A1/EPHA2 -0.055 0.137 -9999.0 0.0 -0.551 10.0 10.0 SEC6/SEC8 -0.037 0.107 -9999.0 0.0 -0.496 8.0 8.0 MGAT3 -0.055 0.15 -9999.0 0.0 -0.51 4.0 4.0 HGF/MET -0.039 0.103 -9999.0 0.0 -0.587 3.0 3.0 HGF 0.007 0.074 -9999.0 0.0 -0.537 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.001 0.103 -9999.0 0.0 -0.596 2.0 2.0 actin cable formation 0.027 0.116 -9999.0 0.0 -0.393 3.0 3.0 KIAA1543 0.009 0.116 -9999.0 0.0 -0.505 4.0 4.0 KIFC3 0.004 0.11 -9999.0 0.0 -0.45 3.0 3.0 NCK1 0.006 0.083 -9999.0 0.0 -0.609 4.0 4.0 EXOC3 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.009 0.103 -9999.0 0.0 -0.507 1.0 1.0 NCK1/GIT1 0.016 0.066 -9999.0 0.0 -0.417 5.0 5.0 mol:GDP 0.001 0.105 -9999.0 0.0 -0.533 1.0 1.0 EXOC4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.007 0.104 -9999.0 0.0 -0.507 1.0 1.0 PIP5K1C 0.01 0.101 -9999.0 0.0 -0.507 1.0 1.0 LIMA1 0.002 0.094 -9999.0 0.0 -0.561 6.0 6.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.016 0.128 -9999.0 0.0 -0.484 5.0 5.0 adherens junction assembly 0.022 0.121 -9999.0 0.0 -0.517 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.045 0.1 -9999.0 0.0 -0.487 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.006 0.092 -9999.0 0.0 -0.417 10.0 10.0 MET 0.003 0.086 -9999.0 0.0 -0.514 6.0 6.0 PLEKHA7 0.01 0.101 -9999.0 0.0 -0.507 1.0 1.0 mol:GTP 0.002 0.118 -9999.0 0.0 -0.367 15.0 15.0 establishment of epithelial cell apical/basal polarity 0.027 0.125 -9999.0 0.0 -0.469 8.0 8.0 cortical actin cytoskeleton stabilization 0.001 0.103 -9999.0 0.0 -0.589 2.0 2.0 regulation of cell-cell adhesion 0.01 0.106 -9999.0 0.0 -0.475 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.001 0.103 -9999.0 0.0 -0.596 2.0 2.0