E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.008 0.15 -9999.0 0.0 -0.515 16.0 16.0 KLHL20 0.031 0.12 0.219 11.0 -0.249 18.0 29.0 CYFIP2 0.012 0.111 -9999.0 0.0 -0.459 11.0 11.0 Rac1/GDP 0.052 0.14 0.297 6.0 -0.405 8.0 14.0 ENAH -0.02 0.156 -9999.0 0.0 -0.529 16.0 16.0 AP1M1 0.035 0.036 -9999.0 0.0 -0.484 1.0 1.0 RAP1B 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.093 -9999.0 0.0 -0.301 15.0 15.0 CDC42/GTP 0.038 0.101 -9999.0 0.0 -0.347 7.0 7.0 ABI1/Sra1/Nap1 -0.028 0.058 -9999.0 0.0 -0.18 21.0 21.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.016 0.127 -9999.0 0.0 -0.273 29.0 29.0 RAPGEF1 0.033 0.156 0.32 3.0 -0.493 11.0 14.0 CTNND1 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.001 0.155 -9999.0 0.0 -0.528 16.0 16.0 CRK 0.03 0.164 -9999.0 0.0 -0.552 11.0 11.0 E-cadherin/gamma catenin/alpha catenin 0.051 0.081 -9999.0 0.0 -0.298 10.0 10.0 alphaE/beta7 Integrin 0.015 0.1 -9999.0 0.0 -0.345 14.0 14.0 IQGAP1 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.023 0.068 -9999.0 0.0 -0.264 10.0 10.0 Rap1/GTP/I-afadin 0.057 0.056 -9999.0 0.0 -0.271 5.0 5.0 DLG1 -0.009 0.15 -9999.0 0.0 -0.515 16.0 16.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.01 0.055 -9999.0 0.0 -0.266 6.0 6.0 MLLT4 0.022 0.086 -9999.0 0.0 -0.484 6.0 6.0 ARF6/GTP/NME1/Tiam1 0.049 0.061 -9999.0 0.0 -0.283 5.0 5.0 PI3K -0.01 0.073 -9999.0 0.0 -0.378 5.0 5.0 ARF6 0.029 0.051 -9999.0 0.0 -0.484 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.033 0.086 -9999.0 0.0 -0.35 10.0 10.0 TIAM1 0.029 0.053 -9999.0 0.0 -0.392 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.052 0.096 -9999.0 0.0 -0.261 15.0 15.0 AKT1 0.031 0.069 0.184 5.0 -0.207 5.0 10.0 PIK3R1 0.03 0.061 -9999.0 0.0 -0.484 3.0 3.0 CDH1 0.013 0.11 -9999.0 0.0 -0.484 10.0 10.0 RhoA/GDP 0.064 0.142 0.29 5.0 -0.404 8.0 13.0 actin cytoskeleton organization 0.032 0.095 0.188 15.0 -0.18 18.0 33.0 CDC42/GDP 0.059 0.143 0.297 6.0 -0.404 8.0 14.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.015 0.056 -9999.0 0.0 -0.233 10.0 10.0 ITGB7 0.003 0.128 -9999.0 0.0 -0.484 14.0 14.0 RAC1 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.056 0.103 -9999.0 0.0 -0.278 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.088 -9999.0 0.0 -0.26 15.0 15.0 mol:GDP 0.05 0.156 0.298 6.0 -0.433 11.0 17.0 CDC42/GTP/IQGAP1 0.043 0.021 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.035 0.019 -9999.0 0.0 -0.209 1.0 1.0 p120 catenin/RhoA/GDP 0.074 0.148 0.306 4.0 -0.415 8.0 12.0 RAC1/GTP/IQGAP1 0.041 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.052 0.029 -9999.0 0.0 -0.35 1.0 1.0 RHOA 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.034 0.019 -9999.0 0.0 -0.209 1.0 1.0 CTNNA1 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.029 0.075 0.153 17.0 -0.193 5.0 22.0 NME1 0.034 0.036 -9999.0 0.0 -0.484 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.009 0.148 -9999.0 0.0 -0.515 16.0 16.0 regulation of cell-cell adhesion -0.0 0.068 -9999.0 0.0 -0.301 7.0 7.0 WASF2 0.014 0.054 0.11 12.0 -0.15 3.0 15.0 Rap1/GTP 0.074 0.128 0.306 4.0 -0.395 7.0 11.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.038 0.117 -9999.0 0.0 -0.256 24.0 24.0 CCND1 0.032 0.088 0.174 17.0 -0.241 5.0 22.0 VAV2 0.005 0.286 -9999.0 0.0 -0.708 24.0 24.0 RAP1/GDP 0.077 0.138 0.327 4.0 -0.411 7.0 11.0 adherens junction assembly -0.009 0.143 -9999.0 0.0 -0.497 16.0 16.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.018 0.119 -9999.0 0.0 -0.251 27.0 27.0 E-cadherin/beta catenin -0.003 0.08 -9999.0 0.0 -0.337 11.0 11.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.02 0.144 -9999.0 0.0 -0.592 11.0 11.0 PIK3CA 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.045 0.136 -9999.0 0.0 -0.399 23.0 23.0 E-cadherin/beta catenin/alpha catenin 0.038 0.103 -9999.0 0.0 -0.304 15.0 15.0 ITGAE 0.027 0.028 -9999.0 0.0 -0.209 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.002 0.159 -9999.0 0.0 -0.541 16.0 16.0