Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.016 0.115 -9999.0 0.0 -0.553 6.0 6.0 IHH 0.027 0.094 -9999.0 0.0 -0.432 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.074 0.142 -9999.0 0.0 -0.309 47.0 47.0 LRPAP1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.074 0.141 0.307 47.0 -9999.0 0.0 47.0 SMO/beta Arrestin2 0.007 0.12 -9999.0 0.0 -0.397 9.0 9.0 SMO -0.007 0.115 -9999.0 0.0 -0.338 20.0 20.0 AKT1 -0.023 0.16 -9999.0 0.0 -0.407 25.0 25.0 ARRB2 0.026 0.038 -9999.0 0.0 -0.484 1.0 1.0 BOC 0.027 0.056 -9999.0 0.0 -0.243 8.0 8.0 ADRBK1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.007 0.114 -9999.0 0.0 -0.333 20.0 20.0 STIL -0.002 0.109 0.352 2.0 -0.3 8.0 10.0 DHH N/PTCH2 0.053 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.029 0.075 -9999.0 0.0 -0.297 9.0 9.0 PIK3CA 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.004 0.165 -9999.0 0.0 -0.867 6.0 6.0 determination of left/right symmetry -0.007 0.114 -9999.0 0.0 -0.333 20.0 20.0 PIK3R1 0.03 0.061 -9999.0 0.0 -0.484 3.0 3.0 skeletal system development 0.004 0.163 -9999.0 0.0 -0.855 6.0 6.0 IHH N/Hhip -0.013 0.16 -9999.0 0.0 -0.402 28.0 28.0 DHH N/Hhip -0.004 0.133 -9999.0 0.0 -0.35 25.0 25.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.007 0.114 -9999.0 0.0 -0.333 20.0 20.0 pancreas development -0.034 0.17 -9999.0 0.0 -0.41 34.0 34.0 HHAT -0.003 0.132 -9999.0 0.0 -0.411 19.0 19.0 PI3K 0.047 0.049 -9999.0 0.0 -0.35 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.12 0.203 -9999.0 0.0 -0.331 92.0 92.0 somite specification -0.007 0.114 -9999.0 0.0 -0.333 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.006 0.093 -9999.0 0.0 -0.251 24.0 24.0 SHH Np/Cholesterol/PTCH2 0.009 0.083 -9999.0 0.0 -0.275 15.0 15.0 SHH Np/Cholesterol/Megalin 0.008 0.083 -9999.0 0.0 -0.275 15.0 15.0 SHH -0.012 0.098 -9999.0 0.0 -0.357 15.0 15.0 catabolic process 0.008 0.077 -9999.0 0.0 -0.332 9.0 9.0 SMO/Vitamin D3 -0.016 0.11 -9999.0 0.0 -0.33 14.0 14.0 SHH Np/Cholesterol/Hhip -0.031 0.132 -9999.0 0.0 -0.307 35.0 35.0 LRP2 0.035 0.024 -9999.0 0.0 -0.209 2.0 2.0 receptor-mediated endocytosis -0.016 0.106 -9999.0 0.0 -0.336 11.0 11.0 SHH Np/Cholesterol/BOC 0.004 0.085 -9999.0 0.0 -0.276 15.0 15.0 SHH Np/Cholesterol/CDO 0.008 0.083 -9999.0 0.0 -0.275 15.0 15.0 mesenchymal cell differentiation 0.031 0.131 0.305 35.0 -9999.0 0.0 35.0 mol:Vitamin D3 0.005 0.107 0.363 2.0 -0.275 12.0 14.0 IHH N/PTCH2 0.046 0.062 -9999.0 0.0 -0.319 5.0 5.0 CDON 0.035 0.024 -9999.0 0.0 -0.209 2.0 2.0 IHH N/PTCH1 0.028 0.083 -9999.0 0.0 -0.335 9.0 9.0 Megalin/LRPAP1 0.052 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.004 0.077 -9999.0 0.0 -0.274 15.0 15.0 PTCH1 0.008 0.078 -9999.0 0.0 -0.333 9.0 9.0 HHIP -0.034 0.17 -9999.0 0.0 -0.411 34.0 34.0