Glioblastoma Multiforme: Correlation between gene mutation status and selected clinical features
Maintained by TCGA GDAC Team (Broad Institute/Dana-Farber Cancer Institute/Harvard Medical School)
Overview
Introduction

This pipeline computes the correlation between significantly recurrent gene mutations and selected clinical features.

Summary

Testing the association between mutation status of 295 genes and 7 clinical features across 269 patients, 34 significant findings detected with Q value < 0.25.

  • IDH1 mutation correlated to 'AGE'.

  • ZNF704 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • ZNF784 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • PUF60 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • GUF1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • C1ORF187 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • EIF4A3 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • RBM3 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • FOXF1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • PRKRIP1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • OR5W2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • CHEK1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • C21ORF58 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • SLC4A11 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • ARID3B mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • MTMR7 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • DSCAM mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • KRT13 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • CDKN2C mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • RAG1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • JHDM1D mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • LMO1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • NFKBIL2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • JAG2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • CXCL6 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • CCDC105 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • SPAM1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • CTDSP1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • TLR6 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • OPRM1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • GJB1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • TGM3 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • LEFTY1 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

  • CHP2 mutation correlated to 'KARNOFSKY.PERFORMANCE.SCORE'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between mutation status of 295 genes and 7 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 34 significant findings detected.

Clinical
Features
Time
to
Death
AGE GENDER KARNOFSKY
PERFORMANCE
SCORE
HISTOLOGICAL
TYPE
RADIATIONS
RADIATION
REGIMENINDICATION
NEOADJUVANT
THERAPY
nMutated (%) nWild-Type logrank test t-test Fisher's exact test t-test Fisher's exact test Fisher's exact test Fisher's exact test
IDH1 15 (6%) 254 0.00425
(1.00)
2.36e-05
(0.0479)
1
(1.00)
0.00152
(1.00)
1
(1.00)
0.00357
(1.00)
0.181
(1.00)
ZNF704 5 (2%) 264 0.511
(1.00)
0.875
(1.00)
0.657
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.183
(1.00)
0.364
(1.00)
ZNF784 3 (1%) 266 0.344
(1.00)
0.719
(1.00)
0.555
(1.00)
3.03e-05
(0.0612)
1
(1.00)
1
(1.00)
1
(1.00)
PUF60 4 (1%) 265 0.502
(1.00)
0.0718
(1.00)
0.3
(1.00)
3.02e-05
(0.0612)
1
(1.00)
0.0947
(1.00)
0.146
(1.00)
GUF1 4 (1%) 265 0.432
(1.00)
0.943
(1.00)
0.621
(1.00)
3.03e-05
(0.0612)
1
(1.00)
1
(1.00)
0.63
(1.00)
C1ORF187 3 (1%) 266 0.941
(1.00)
0.956
(1.00)
0.555
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.236
(1.00)
0.0504
(1.00)
EIF4A3 3 (1%) 266 0.479
(1.00)
0.235
(1.00)
1
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.297
(1.00)
RBM3 3 (1%) 266 0.226
(1.00)
0.803
(1.00)
0.296
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.236
(1.00)
0.557
(1.00)
FOXF1 3 (1%) 266 0.775
(1.00)
0.879
(1.00)
0.555
(1.00)
3.03e-05
(0.0612)
1
(1.00)
1
(1.00)
1
(1.00)
PRKRIP1 3 (1%) 266 0.997
(1.00)
0.567
(1.00)
1
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.554
(1.00)
0.557
(1.00)
OR5W2 6 (2%) 263 0.234
(1.00)
0.129
(1.00)
0.67
(1.00)
3.02e-05
(0.0612)
1
(1.00)
0.668
(1.00)
1
(1.00)
CHEK1 5 (2%) 264 0.473
(1.00)
0.129
(1.00)
1
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.653
(1.00)
0.654
(1.00)
C21ORF58 5 (2%) 264 0.602
(1.00)
0.257
(1.00)
0.355
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.0359
(1.00)
0.0653
(1.00)
SLC4A11 5 (2%) 264 0.348
(1.00)
0.186
(1.00)
1
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.653
(1.00)
1
(1.00)
ARID3B 5 (2%) 264 0.879
(1.00)
0.13
(1.00)
1
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.183
(1.00)
0.0653
(1.00)
MTMR7 4 (1%) 265 0.326
(1.00)
0.0161
(1.00)
1
(1.00)
3.03e-05
(0.0612)
1
(1.00)
1
(1.00)
0.3
(1.00)
DSCAM 9 (3%) 260 0.803
(1.00)
0.266
(1.00)
0.496
(1.00)
3.01e-05
(0.061)
1
(1.00)
1
(1.00)
0.731
(1.00)
KRT13 4 (1%) 265 0.249
(1.00)
0.444
(1.00)
0.621
(1.00)
3.03e-05
(0.0612)
1
(1.00)
1
(1.00)
0.3
(1.00)
CDKN2C 4 (1%) 265 0.631
(1.00)
0.331
(1.00)
1
(1.00)
3.03e-05
(0.0612)
1
(1.00)
1
(1.00)
0.63
(1.00)
RAG1 5 (2%) 264 0.0866
(1.00)
0.499
(1.00)
0.0584
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.183
(1.00)
0.364
(1.00)
JHDM1D 6 (2%) 263 0.0963
(1.00)
0.561
(1.00)
0.193
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.384
(1.00)
0.199
(1.00)
LMO1 3 (1%) 266 0.588
(1.00)
0.53
(1.00)
0.046
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.554
(1.00)
0.297
(1.00)
NFKBIL2 6 (2%) 263 0.916
(1.00)
0.309
(1.00)
0.67
(1.00)
3.02e-05
(0.0612)
1
(1.00)
0.181
(1.00)
0.417
(1.00)
JAG2 4 (1%) 265 0.38
(1.00)
0.502
(1.00)
1
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.593
(1.00)
1
(1.00)
CXCL6 3 (1%) 266 0.85
(1.00)
0.704
(1.00)
1
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.236
(1.00)
0.557
(1.00)
CCDC105 4 (1%) 265 0.341
(1.00)
0.772
(1.00)
0.621
(1.00)
3.02e-05
(0.0612)
1
(1.00)
0.311
(1.00)
1
(1.00)
SPAM1 6 (2%) 263 0.577
(1.00)
0.358
(1.00)
0.67
(1.00)
3.01e-05
(0.0611)
1
(1.00)
0.668
(1.00)
0.0874
(1.00)
CTDSP1 4 (1%) 265 0.526
(1.00)
0.266
(1.00)
1
(1.00)
3.03e-05
(0.0612)
1
(1.00)
1
(1.00)
0.146
(1.00)
TLR6 6 (2%) 263 0.918
(1.00)
0.757
(1.00)
0.0243
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.384
(1.00)
0.199
(1.00)
OPRM1 4 (1%) 265 0.575
(1.00)
0.65
(1.00)
0.621
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.311
(1.00)
1
(1.00)
GJB1 4 (1%) 265 0.374
(1.00)
0.436
(1.00)
0.135
(1.00)
3.03e-05
(0.0612)
1
(1.00)
1
(1.00)
1
(1.00)
TGM3 7 (3%) 262 0.589
(1.00)
0.639
(1.00)
0.00978
(1.00)
3.02e-05
(0.0612)
1
(1.00)
0.212
(1.00)
0.713
(1.00)
LEFTY1 4 (1%) 265 0.497
(1.00)
0.177
(1.00)
0.135
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.593
(1.00)
0.63
(1.00)
CHP2 4 (1%) 265 0.168
(1.00)
0.792
(1.00)
0.621
(1.00)
3.03e-05
(0.0612)
1
(1.00)
0.311
(1.00)
0.3
(1.00)
PIK3R1 17 (6%) 252 0.702
(1.00)
0.848
(1.00)
1
(1.00)
0.682
(1.00)
1
(1.00)
0.422
(1.00)
0.44
(1.00)
KRTAP5-5 16 (6%) 253 0.0204
(1.00)
0.633
(1.00)
1
(1.00)
0.485
(1.00)
1
(1.00)
0.281
(1.00)
0.601
(1.00)
C7ORF52 6 (2%) 263 0.493
(1.00)
0.382
(1.00)
1
(1.00)
0.49
(1.00)
1
(1.00)
0.668
(1.00)
0.674
(1.00)
CD4 3 (1%) 266 0.295
(1.00)
0.7
(1.00)
0.555
(1.00)
0.73
(1.00)
1
(1.00)
1
(1.00)
0.297
(1.00)
EGFR 53 (20%) 216 0.887
(1.00)
0.61
(1.00)
0.752
(1.00)
0.825
(1.00)
0.527
(1.00)
0.623
(1.00)
0.875
(1.00)
KDSR 5 (2%) 264 0.447
(1.00)
0.245
(1.00)
0.657
(1.00)
0.386
(1.00)
1
(1.00)
0.183
(1.00)
1
(1.00)
MICALCL 12 (4%) 257 0.272
(1.00)
0.699
(1.00)
0.546
(1.00)
0.0089
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
MRM1 4 (1%) 265 0.155
(1.00)
0.595
(1.00)
1
(1.00)
1
(1.00)
0.593
(1.00)
0.63
(1.00)
PIK3CA 19 (7%) 250 0.203
(1.00)
0.752
(1.00)
0.325
(1.00)
0.0193
(1.00)
1
(1.00)
0.799
(1.00)
0.806
(1.00)
PLA2G2A 5 (2%) 264 0.0228
(1.00)
0.0212
(1.00)
0.657
(1.00)
0.346
(1.00)
1
(1.00)
0.0359
(1.00)
0.0653
(1.00)
TP53 80 (30%) 189 0.109
(1.00)
0.769
(1.00)
0.166
(1.00)
0.49
(1.00)
0.552
(1.00)
0.391
(1.00)
0.215
(1.00)
PTEN 77 (29%) 192 0.619
(1.00)
0.0694
(1.00)
1
(1.00)
0.0373
(1.00)
1
(1.00)
0.664
(1.00)
0.264
(1.00)
RB1 20 (7%) 249 0.371
(1.00)
0.863
(1.00)
0.34
(1.00)
0.408
(1.00)
1
(1.00)
1
(1.00)
0.632
(1.00)
FOXRED1 9 (3%) 260 0.973
(1.00)
0.338
(1.00)
0.075
(1.00)
0.415
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
NF1 24 (9%) 245 0.381
(1.00)
0.359
(1.00)
0.828
(1.00)
0.443
(1.00)
1
(1.00)
0.499
(1.00)
0.826
(1.00)
SPTA1 26 (10%) 243 0.152
(1.00)
0.873
(1.00)
0.522
(1.00)
0.782
(1.00)
1
(1.00)
1
(1.00)
0.834
(1.00)
COMMD4 5 (2%) 264 0.0397
(1.00)
0.85
(1.00)
0.163
(1.00)
0.959
(1.00)
1
(1.00)
1
(1.00)
0.654
(1.00)
CRYBA2 6 (2%) 263 0.0639
(1.00)
0.0518
(1.00)
0.67
(1.00)
0.739
(1.00)
1
(1.00)
0.668
(1.00)
1
(1.00)
RYR2 28 (10%) 241 0.606
(1.00)
0.614
(1.00)
0.144
(1.00)
0.257
(1.00)
0.282
(1.00)
0.199
(1.00)
0.838
(1.00)
NRBP2 4 (1%) 265 0.144
(1.00)
0.977
(1.00)
0.3
(1.00)
0.576
(1.00)
1
(1.00)
0.311
(1.00)
0.146
(1.00)
FUT7 5 (2%) 264 0.887
(1.00)
0.157
(1.00)
0.163
(1.00)
0.438
(1.00)
1
(1.00)
0.653
(1.00)
0.00666
(1.00)
HMP19 5 (2%) 264 0.901
(1.00)
0.562
(1.00)
0.657
(1.00)
0.776
(1.00)
1
(1.00)
0.183
(1.00)
0.654
(1.00)
MST1 9 (3%) 260 0.364
(1.00)
0.776
(1.00)
0.727
(1.00)
0.266
(1.00)
1
(1.00)
0.47
(1.00)
1
(1.00)
EML2 8 (3%) 261 0.283
(1.00)
0.363
(1.00)
1
(1.00)
0.222
(1.00)
1
(1.00)
0.267
(1.00)
1
(1.00)
FLG 27 (10%) 242 0.908
(1.00)
0.875
(1.00)
1
(1.00)
0.901
(1.00)
1
(1.00)
0.519
(1.00)
0.68
(1.00)
DNASE1L1 6 (2%) 263 0.822
(1.00)
0.576
(1.00)
1
(1.00)
0.776
(1.00)
1
(1.00)
1
(1.00)
0.674
(1.00)
FOXC1 4 (1%) 265 0.214
(1.00)
0.633
(1.00)
0.621
(1.00)
1
(1.00)
1
(1.00)
0.63
(1.00)
TMEM45A 5 (2%) 264 0.165
(1.00)
0.776
(1.00)
0.355
(1.00)
0.929
(1.00)
1
(1.00)
0.653
(1.00)
1
(1.00)
BID 4 (1%) 265 0.00297
(1.00)
0.888
(1.00)
1
(1.00)
0.776
(1.00)
1
(1.00)
0.0947
(1.00)
0.63
(1.00)
KEL 12 (4%) 257 0.5
(1.00)
0.444
(1.00)
0.361
(1.00)
0.0131
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
MUC2 15 (6%) 254 0.277
(1.00)
0.584
(1.00)
0.785
(1.00)
0.221
(1.00)
1
(1.00)
0.156
(1.00)
0.181
(1.00)
IRF5 5 (2%) 264 0.244
(1.00)
0.611
(1.00)
0.657
(1.00)
0.229
(1.00)
1
(1.00)
1
(1.00)
0.654
(1.00)
BBS1 8 (3%) 261 0.954
(1.00)
0.0348
(1.00)
1
(1.00)
0.0597
(1.00)
1
(1.00)
0.711
(1.00)
0.714
(1.00)
PRMT6 5 (2%) 264 0.0871
(1.00)
0.309
(1.00)
1
(1.00)
1
(1.00)
0.183
(1.00)
0.654
(1.00)
RNF34 3 (1%) 266 0.051
(1.00)
0.612
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
GABRA6 9 (3%) 260 0.123
(1.00)
0.341
(1.00)
0.727
(1.00)
0.748
(1.00)
1
(1.00)
1
(1.00)
0.492
(1.00)
TMEM155 3 (1%) 266 0.262
(1.00)
0.65
(1.00)
1
(1.00)
0.73
(1.00)
1
(1.00)
1
(1.00)
0.297
(1.00)
ADRA2B 6 (2%) 263 0.486
(1.00)
0.636
(1.00)
0.67
(1.00)
0.45
(1.00)
0.0847
(1.00)
0.668
(1.00)
0.199
(1.00)
ADAM29 9 (3%) 260 0.795
(1.00)
0.136
(1.00)
0.163
(1.00)
0.757
(1.00)
1
(1.00)
0.724
(1.00)
0.16
(1.00)
HEATR7B2 12 (4%) 257 0.291
(1.00)
0.84
(1.00)
1
(1.00)
0.267
(1.00)
1
(1.00)
0.527
(1.00)
1
(1.00)
SVOP 3 (1%) 266 0.327
(1.00)
0.292
(1.00)
0.555
(1.00)
1
(1.00)
0.554
(1.00)
0.297
(1.00)
CEACAM16 7 (3%) 262 0.823
(1.00)
0.268
(1.00)
0.257
(1.00)
0.296
(1.00)
1
(1.00)
1
(1.00)
0.713
(1.00)
TTN 61 (23%) 208 0.379
(1.00)
0.824
(1.00)
0.764
(1.00)
0.0308
(1.00)
1
(1.00)
1
(1.00)
0.763
(1.00)
GJD4 3 (1%) 266 0.14
(1.00)
0.649
(1.00)
1
(1.00)
1
(1.00)
0.236
(1.00)
0.557
(1.00)
RIC3 3 (1%) 266 0.309
(1.00)
0.661
(1.00)
0.296
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
CDH18 10 (4%) 259 0.0408
(1.00)
0.782
(1.00)
0.503
(1.00)
0.773
(1.00)
1
(1.00)
0.73
(1.00)
0.507
(1.00)
STAG2 10 (4%) 259 0.676
(1.00)
0.144
(1.00)
0.176
(1.00)
0.0293
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
FAM113B 3 (1%) 266 0.638
(1.00)
0.727
(1.00)
0.296
(1.00)
1
(1.00)
1
(1.00)
0.557
(1.00)
C22ORF32 4 (1%) 265 0.571
(1.00)
0.701
(1.00)
0.621
(1.00)
0.572
(1.00)
1
(1.00)
1
(1.00)
0.63
(1.00)
RIMS2 14 (5%) 255 0.492
(1.00)
0.322
(1.00)
0.391
(1.00)
0.0145
(1.00)
0.18
(1.00)
0.559
(1.00)
0.0892
(1.00)
IL17RA 8 (3%) 261 0.695
(1.00)
0.182
(1.00)
0.715
(1.00)
0.493
(1.00)
0.117
(1.00)
0.442
(1.00)
0.265
(1.00)
CNTNAP2 14 (5%) 255 0.929
(1.00)
0.421
(1.00)
0.58
(1.00)
0.0905
(1.00)
0.164
(1.00)
0.237
(1.00)
0.581
(1.00)
BRAF 5 (2%) 264 0.335
(1.00)
0.487
(1.00)
0.355
(1.00)
0.0938
(1.00)
1
(1.00)
0.33
(1.00)
0.161
(1.00)
DAZAP1 3 (1%) 266 0.567
(1.00)
0.14
(1.00)
0.555
(1.00)
0.0514
(1.00)
0.236
(1.00)
0.557
(1.00)
SLCO6A1 10 (4%) 259 0.785
(1.00)
0.671
(1.00)
1
(1.00)
0.355
(1.00)
1
(1.00)
0.178
(1.00)
0.0966
(1.00)
MFAP4 3 (1%) 266 0.979
(1.00)
0.553
(1.00)
0.296
(1.00)
1
(1.00)
0.554
(1.00)
0.297
(1.00)
CALN1 9 (3%) 260 0.0625
(1.00)
0.979
(1.00)
0.727
(1.00)
0.234
(1.00)
1
(1.00)
0.724
(1.00)
0.492
(1.00)
GPR135 3 (1%) 266 0.865
(1.00)
0.806
(1.00)
1
(1.00)
0.515
(1.00)
1
(1.00)
0.554
(1.00)
0.297
(1.00)
PCLO 18 (7%) 251 0.224
(1.00)
0.998
(1.00)
0.455
(1.00)
0.156
(1.00)
1
(1.00)
1
(1.00)
0.458
(1.00)
C9ORF150 6 (2%) 263 0.694
(1.00)
0.144
(1.00)
1
(1.00)
0.023
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
CC2D1A 9 (3%) 260 0.998
(1.00)
0.845
(1.00)
1
(1.00)
0.328
(1.00)
1
(1.00)
0.724
(1.00)
0.731
(1.00)
NPL 3 (1%) 266 0.53
(1.00)
0.206
(1.00)
0.296
(1.00)
1
(1.00)
0.236
(1.00)
1
(1.00)
FBLN2 9 (3%) 260 0.958
(1.00)
0.344
(1.00)
1
(1.00)
0.308
(1.00)
1
(1.00)
0.28
(1.00)
1
(1.00)
SPNS1 3 (1%) 266 0.477
(1.00)
0.606
(1.00)
0.555
(1.00)
0.229
(1.00)
1
(1.00)
0.554
(1.00)
0.297
(1.00)
POTEB 9 (3%) 260 0.577
(1.00)
0.803
(1.00)
1
(1.00)
0.971
(1.00)
1
(1.00)
0.47
(1.00)
0.299
(1.00)
OR5D13 7 (3%) 262 0.306
(1.00)
0.885
(1.00)
0.102
(1.00)
0.0399
(1.00)
0.0682
(1.00)
0.438
(1.00)
0.264
(1.00)
SUSD3 6 (2%) 263 0.887
(1.00)
0.0668
(1.00)
1
(1.00)
0.903
(1.00)
1
(1.00)
0.668
(1.00)
0.417
(1.00)
OR5AR1 4 (1%) 265 0.395
(1.00)
0.0254
(1.00)
0.621
(1.00)
0.12
(1.00)
1
(1.00)
0.593
(1.00)
0.3
(1.00)
GABRB2 7 (3%) 262 0.213
(1.00)
0.00863
(1.00)
0.257
(1.00)
0.45
(1.00)
1
(1.00)
0.212
(1.00)
0.713
(1.00)
HCN1 10 (4%) 259 0.0208
(1.00)
0.13
(1.00)
0.0387
(1.00)
0.346
(1.00)
1
(1.00)
0.0128
(1.00)
0.181
(1.00)
LPHN1 10 (4%) 259 0.337
(1.00)
0.0921
(1.00)
1
(1.00)
0.00369
(1.00)
1
(1.00)
0.512
(1.00)
0.749
(1.00)
FAM83H 10 (4%) 259 0.877
(1.00)
0.825
(1.00)
0.503
(1.00)
0.115
(1.00)
1
(1.00)
0.73
(1.00)
0.749
(1.00)
ACSM4 7 (3%) 262 0.0785
(1.00)
0.417
(1.00)
0.257
(1.00)
0.415
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
SEMG1 8 (3%) 261 0.682
(1.00)
0.78
(1.00)
0.465
(1.00)
0.146
(1.00)
1
(1.00)
0.267
(1.00)
0.152
(1.00)
SALL2 4 (1%) 265 0.114
(1.00)
0.347
(1.00)
1
(1.00)
0.73
(1.00)
1
(1.00)
1
(1.00)
0.63
(1.00)
MAGEB1 6 (2%) 263 0.289
(1.00)
0.153
(1.00)
1
(1.00)
0.508
(1.00)
1
(1.00)
0.668
(1.00)
0.0874
(1.00)
TRPM2 10 (4%) 259 0.602
(1.00)
0.552
(1.00)
0.751
(1.00)
0.509
(1.00)
0.164
(1.00)
0.178
(1.00)
0.749
(1.00)
WSCD2 5 (2%) 264 0.0782
(1.00)
0.824
(1.00)
1
(1.00)
0.776
(1.00)
1
(1.00)
1
(1.00)
0.654
(1.00)
ZMYM3 10 (4%) 259 0.463
(1.00)
0.0702
(1.00)
1
(1.00)
0.00888
(1.00)
1
(1.00)
0.512
(1.00)
0.331
(1.00)
KIF21B 9 (3%) 260 0.111
(1.00)
0.511
(1.00)
0.496
(1.00)
0.0597
(1.00)
1
(1.00)
1
(1.00)
0.731
(1.00)
LRRC55 6 (2%) 263 0.728
(1.00)
0.278
(1.00)
1
(1.00)
0.0938
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
PRIM2 5 (2%) 264 0.484
(1.00)
0.53
(1.00)
0.0584
(1.00)
1
(1.00)
0.0359
(1.00)
0.0653
(1.00)
CDH9 9 (3%) 260 0.365
(1.00)
0.123
(1.00)
0.727
(1.00)
0.653
(1.00)
1
(1.00)
0.724
(1.00)
0.299
(1.00)
ACVR2A 5 (2%) 264 0.983
(1.00)
0.689
(1.00)
1
(1.00)
0.513
(1.00)
1
(1.00)
0.33
(1.00)
0.161
(1.00)
ZFP42 7 (3%) 262 0.516
(1.00)
0.68
(1.00)
0.257
(1.00)
0.508
(1.00)
1
(1.00)
1
(1.00)
0.713
(1.00)
DUS3L 7 (3%) 262 0.687
(1.00)
0.783
(1.00)
1
(1.00)
0.379
(1.00)
1
(1.00)
1
(1.00)
0.713
(1.00)
GABRA1 7 (3%) 262 0.724
(1.00)
0.307
(1.00)
1
(1.00)
0.0938
(1.00)
1
(1.00)
1
(1.00)
0.264
(1.00)
PLXNB2 6 (2%) 263 0.623
(1.00)
0.0277
(1.00)
1
(1.00)
0.248
(1.00)
1
(1.00)
0.384
(1.00)
1
(1.00)
DNMT3L 6 (2%) 263 0.988
(1.00)
0.515
(1.00)
0.0905
(1.00)
0.947
(1.00)
1
(1.00)
0.668
(1.00)
0.417
(1.00)
SEMA3C 8 (3%) 261 0.0409
(1.00)
0.902
(1.00)
0.715
(1.00)
0.805
(1.00)
1
(1.00)
0.267
(1.00)
0.152
(1.00)
TMEM132D 10 (4%) 259 0.379
(1.00)
0.902
(1.00)
0.00516
(1.00)
0.59
(1.00)
1
(1.00)
0.296
(1.00)
1
(1.00)
CPNE3 3 (1%) 266 0.793
(1.00)
0.847
(1.00)
1
(1.00)
0.776
(1.00)
1
(1.00)
1
(1.00)
ZNF208 8 (3%) 261 0.612
(1.00)
0.26
(1.00)
0.0276
(1.00)
0.163
(1.00)
1
(1.00)
0.267
(1.00)
0.475
(1.00)
GRM3 8 (3%) 261 0.694
(1.00)
0.0435
(1.00)
1
(1.00)
0.692
(1.00)
1
(1.00)
0.0592
(1.00)
0.0275
(1.00)
STARD8 7 (3%) 262 0.402
(1.00)
0.671
(1.00)
0.257
(1.00)
0.383
(1.00)
1
(1.00)
0.682
(1.00)
0.713
(1.00)
MUC16 33 (12%) 236 0.287
(1.00)
0.74
(1.00)
0.442
(1.00)
0.731
(1.00)
0.376
(1.00)
0.691
(1.00)
0.445
(1.00)
QKI 5 (2%) 264 0.782
(1.00)
0.669
(1.00)
1
(1.00)
0.882
(1.00)
1
(1.00)
0.653
(1.00)
0.364
(1.00)
COL5A3 9 (3%) 260 0.424
(1.00)
0.394
(1.00)
0.727
(1.00)
0.334
(1.00)
1
(1.00)
0.28
(1.00)
0.492
(1.00)
SARDH 5 (2%) 264 0.425
(1.00)
0.577
(1.00)
0.657
(1.00)
0.13
(1.00)
1
(1.00)
0.33
(1.00)
0.654
(1.00)
UBE2M 3 (1%) 266 0.27
(1.00)
0.915
(1.00)
0.555
(1.00)
0.229
(1.00)
1
(1.00)
0.236
(1.00)
1
(1.00)
TPTE2 6 (2%) 263 0.322
(1.00)
0.796
(1.00)
0.67
(1.00)
0.415
(1.00)
1
(1.00)
0.0815
(1.00)
0.674
(1.00)
ACRC 6 (2%) 263 0.668
(1.00)
0.505
(1.00)
0.67
(1.00)
0.559
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
NAPRT1 4 (1%) 265 0.395
(1.00)
0.517
(1.00)
1
(1.00)
0.146
(1.00)
1
(1.00)
0.593
(1.00)
0.63
(1.00)
DND1 4 (1%) 265 0.744
(1.00)
0.145
(1.00)
0.621
(1.00)
0.528
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
FAM132A 4 (1%) 265 0.356
(1.00)
0.19
(1.00)
0.621
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
ABCC9 9 (3%) 260 0.742
(1.00)
0.603
(1.00)
0.727
(1.00)
0.555
(1.00)
1
(1.00)
1
(1.00)
0.16
(1.00)
ADAMTS16 10 (4%) 259 0.0593
(1.00)
0.763
(1.00)
0.503
(1.00)
0.0403
(1.00)
1
(1.00)
0.512
(1.00)
0.507
(1.00)
MAGEB4 5 (2%) 264 0.159
(1.00)
0.309
(1.00)
0.0584
(1.00)
0.0938
(1.00)
1
(1.00)
0.653
(1.00)
1
(1.00)
ARHGEF2 6 (2%) 263 0.732
(1.00)
0.36
(1.00)
0.67
(1.00)
0.296
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
HNF4A 6 (2%) 263 0.877
(1.00)
0.47
(1.00)
0.193
(1.00)
0.559
(1.00)
1
(1.00)
0.668
(1.00)
0.674
(1.00)
ASB2 4 (1%) 265 0.382
(1.00)
0.327
(1.00)
0.3
(1.00)
0.759
(1.00)
1
(1.00)
0.593
(1.00)
0.0184
(1.00)
GAK 6 (2%) 263 0.0716
(1.00)
0.961
(1.00)
1
(1.00)
0.513
(1.00)
1
(1.00)
1
(1.00)
0.0874
(1.00)
SCN9A 11 (4%) 258 0.259
(1.00)
0.84
(1.00)
0.751
(1.00)
0.888
(1.00)
1
(1.00)
0.332
(1.00)
1
(1.00)
SLCO5A1 6 (2%) 263 0.874
(1.00)
0.914
(1.00)
0.193
(1.00)
0.0806
(1.00)
1
(1.00)
0.384
(1.00)
0.674
(1.00)
DPPA4 5 (2%) 264 0.354
(1.00)
0.35
(1.00)
0.657
(1.00)
0.903
(1.00)
1
(1.00)
0.653
(1.00)
1
(1.00)
OR52M1 6 (2%) 263 0.537
(1.00)
0.0862
(1.00)
0.67
(1.00)
0.638
(1.00)
1
(1.00)
0.181
(1.00)
0.0874
(1.00)
POM121L12 7 (3%) 262 0.661
(1.00)
0.379
(1.00)
0.102
(1.00)
0.513
(1.00)
1
(1.00)
1
(1.00)
0.264
(1.00)
TRAT1 5 (2%) 264 0.6
(1.00)
0.658
(1.00)
1
(1.00)
0.407
(1.00)
1
(1.00)
1
(1.00)
0.654
(1.00)
ZPBP 5 (2%) 264 0.56
(1.00)
0.496
(1.00)
0.0584
(1.00)
0.929
(1.00)
1
(1.00)
1
(1.00)
0.161
(1.00)
LRFN5 7 (3%) 262 0.714
(1.00)
0.831
(1.00)
0.257
(1.00)
0.959
(1.00)
1
(1.00)
0.212
(1.00)
0.713
(1.00)
PCSK4 5 (2%) 264 0.944
(1.00)
0.288
(1.00)
0.0057
(1.00)
0.614
(1.00)
1
(1.00)
0.183
(1.00)
1
(1.00)
ARHGAP9 7 (3%) 262 0.525
(1.00)
0.932
(1.00)
1
(1.00)
0.0806
(1.00)
1
(1.00)
0.682
(1.00)
0.43
(1.00)
DOCK5 11 (4%) 258 0.478
(1.00)
0.476
(1.00)
1
(1.00)
0.888
(1.00)
0.0847
(1.00)
0.746
(1.00)
0.339
(1.00)
GLT8D2 4 (1%) 265 0.0521
(1.00)
0.2
(1.00)
0.621
(1.00)
1
(1.00)
0.0947
(1.00)
0.63
(1.00)
TRHDE 8 (3%) 261 0.573
(1.00)
0.972
(1.00)
0.465
(1.00)
0.631
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
RABGGTA 4 (1%) 265 0.106
(1.00)
0.754
(1.00)
0.621
(1.00)
0.635
(1.00)
1
(1.00)
0.593
(1.00)
1
(1.00)
OR4C12 4 (1%) 265 0.938
(1.00)
0.345
(1.00)
0.3
(1.00)
0.759
(1.00)
1
(1.00)
0.593
(1.00)
1
(1.00)
LRP2 20 (7%) 249 0.659
(1.00)
0.405
(1.00)
0.34
(1.00)
0.45
(1.00)
1
(1.00)
0.622
(1.00)
0.632
(1.00)
KCNN2 4 (1%) 265 0.667
(1.00)
0.59
(1.00)
0.621
(1.00)
0.128
(1.00)
1
(1.00)
0.311
(1.00)
0.63
(1.00)
ANO2 9 (3%) 260 0.0902
(1.00)
0.302
(1.00)
0.727
(1.00)
0.35
(1.00)
1
(1.00)
0.0304
(1.00)
0.299
(1.00)
NPR1 6 (2%) 263 0.405
(1.00)
0.113
(1.00)
0.67
(1.00)
0.0938
(1.00)
1
(1.00)
0.668
(1.00)
0.0874
(1.00)
CDC42EP1 3 (1%) 266 0.0716
(1.00)
0.125
(1.00)
0.555
(1.00)
0.515
(1.00)
1
(1.00)
0.554
(1.00)
1
(1.00)
OR8K3 4 (1%) 265 0.742
(1.00)
0.711
(1.00)
0.621
(1.00)
0.146
(1.00)
1
(1.00)
0.311
(1.00)
0.3
(1.00)
SLC27A2 7 (3%) 262 0.466
(1.00)
0.43
(1.00)
1
(1.00)
0.903
(1.00)
1
(1.00)
0.438
(1.00)
0.264
(1.00)
UFSP1 3 (1%) 266 0.702
(1.00)
0.563
(1.00)
1
(1.00)
1
(1.00)
0.554
(1.00)
0.297
(1.00)
COL6A3 17 (6%) 252 0.193
(1.00)
0.236
(1.00)
0.795
(1.00)
0.354
(1.00)
1
(1.00)
0.789
(1.00)
0.609
(1.00)
KLHL34 6 (2%) 263 0.92
(1.00)
0.812
(1.00)
0.193
(1.00)
0.631
(1.00)
1
(1.00)
1
(1.00)
0.674
(1.00)
DUSP27 8 (3%) 261 0.343
(1.00)
0.918
(1.00)
0.142
(1.00)
0.739
(1.00)
1
(1.00)
0.114
(1.00)
0.475
(1.00)
KRT222 3 (1%) 266 0.82
(1.00)
0.711
(1.00)
0.046
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
SIM2 6 (2%) 263 0.148
(1.00)
0.312
(1.00)
0.424
(1.00)
0.681
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
RARA 5 (2%) 264 0.968
(1.00)
0.508
(1.00)
1
(1.00)
0.195
(1.00)
1
(1.00)
0.183
(1.00)
0.364
(1.00)
PRDM9 8 (3%) 261 0.49
(1.00)
0.695
(1.00)
0.465
(1.00)
0.929
(1.00)
0.117
(1.00)
0.711
(1.00)
0.152
(1.00)
TRPV6 7 (3%) 262 0.552
(1.00)
0.215
(1.00)
0.257
(1.00)
0.415
(1.00)
1
(1.00)
1
(1.00)
0.264
(1.00)
DDX11 6 (2%) 263 0.193
(1.00)
0.635
(1.00)
0.67
(1.00)
0.614
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
OBSCN 23 (9%) 246 0.231
(1.00)
0.889
(1.00)
0.113
(1.00)
0.264
(1.00)
0.0201
(1.00)
0.645
(1.00)
1
(1.00)
OR5K4 4 (1%) 265 0.589
(1.00)
0.136
(1.00)
0.621
(1.00)
1
(1.00)
1
(1.00)
0.63
(1.00)
PRDM12 4 (1%) 265 0.825
(1.00)
0.423
(1.00)
1
(1.00)
1
(1.00)
0.593
(1.00)
0.63
(1.00)
SVOPL 4 (1%) 265 0.56
(1.00)
0.383
(1.00)
0.135
(1.00)
1
(1.00)
0.311
(1.00)
0.3
(1.00)
SLC6A3 8 (3%) 261 0.137
(1.00)
0.97
(1.00)
1
(1.00)
0.631
(1.00)
1
(1.00)
0.711
(1.00)
0.265
(1.00)
ZNF711 5 (2%) 264 0.88
(1.00)
0.713
(1.00)
0.657
(1.00)
0.929
(1.00)
1
(1.00)
0.653
(1.00)
0.654
(1.00)
GABRE 6 (2%) 263 0.473
(1.00)
0.834
(1.00)
0.67
(1.00)
0.407
(1.00)
0.0815
(1.00)
1
(1.00)
SMR3B 3 (1%) 266 0.237
(1.00)
0.224
(1.00)
1
(1.00)
0.776
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
CKMT1A 3 (1%) 266 0.437
(1.00)
0.0472
(1.00)
0.555
(1.00)
0.84
(1.00)
1
(1.00)
1
(1.00)
0.297
(1.00)
OR9G4 5 (2%) 264 0.119
(1.00)
0.56
(1.00)
0.0584
(1.00)
0.695
(1.00)
1
(1.00)
0.653
(1.00)
0.161
(1.00)
MYH2 9 (3%) 260 0.0239
(1.00)
0.699
(1.00)
0.727
(1.00)
0.0336
(1.00)
1
(1.00)
0.724
(1.00)
0.731
(1.00)
PIK3C2G 7 (3%) 262 0.126
(1.00)
0.427
(1.00)
0.00978
(1.00)
0.146
(1.00)
1
(1.00)
0.0341
(1.00)
0.713
(1.00)
TPTE 6 (2%) 263 0.167
(1.00)
0.387
(1.00)
1
(1.00)
0.576
(1.00)
1
(1.00)
0.384
(1.00)
0.674
(1.00)
UBASH3A 7 (3%) 262 0.973
(1.00)
0.356
(1.00)
0.705
(1.00)
0.111
(1.00)
1
(1.00)
0.438
(1.00)
0.264
(1.00)
ECEL1 6 (2%) 263 0.426
(1.00)
0.375
(1.00)
0.67
(1.00)
0.513
(1.00)
1
(1.00)
0.181
(1.00)
1
(1.00)
NCOA4 3 (1%) 266 0.637
(1.00)
0.919
(1.00)
1
(1.00)
0.311
(1.00)
1
(1.00)
0.554
(1.00)
0.297
(1.00)
FTMT 5 (2%) 264 0.812
(1.00)
0.66
(1.00)
0.355
(1.00)
0.929
(1.00)
1
(1.00)
0.653
(1.00)
1
(1.00)
OR8H3 3 (1%) 266 0.214
(1.00)
0.586
(1.00)
0.296
(1.00)
0.759
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
UGT3A2 6 (2%) 263 0.147
(1.00)
0.945
(1.00)
0.0243
(1.00)
0.929
(1.00)
1
(1.00)
1
(1.00)
0.674
(1.00)
TGM2 7 (3%) 262 0.445
(1.00)
0.261
(1.00)
0.705
(1.00)
0.541
(1.00)
1
(1.00)
0.212
(1.00)
1
(1.00)
LGSN 6 (2%) 263 0.208
(1.00)
0.924
(1.00)
0.67
(1.00)
0.234
(1.00)
1
(1.00)
1
(1.00)
0.417
(1.00)
ITK 3 (1%) 266 0.709
(1.00)
0.16
(1.00)
0.296
(1.00)
1
(1.00)
0.554
(1.00)
0.297
(1.00)
FBF1 4 (1%) 265 0.538
(1.00)
0.779
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
0.63
(1.00)
PDGFRA 8 (3%) 261 0.565
(1.00)
0.817
(1.00)
0.265
(1.00)
0.838
(1.00)
1
(1.00)
0.267
(1.00)
0.714
(1.00)
F9 4 (1%) 265 0.197
(1.00)
0.424
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
0.146
(1.00)
TMTC1 6 (2%) 263 0.641
(1.00)
0.0482
(1.00)
0.67
(1.00)
0.0938
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
UGT2B28 5 (2%) 264 0.592
(1.00)
0.583
(1.00)
0.657
(1.00)
0.576
(1.00)
1
(1.00)
0.653
(1.00)
0.364
(1.00)
CXORF22 8 (3%) 261 0.0287
(1.00)
0.594
(1.00)
1
(1.00)
0.266
(1.00)
1
(1.00)
1
(1.00)
0.714
(1.00)
MBIP 3 (1%) 266 0.346
(1.00)
0.465
(1.00)
0.046
(1.00)
0.229
(1.00)
1
(1.00)
1
(1.00)
0.297
(1.00)
SRCRB4D 5 (2%) 264 0.134
(1.00)
0.142
(1.00)
1
(1.00)
0.776
(1.00)
1
(1.00)
0.653
(1.00)
1
(1.00)
LGALS9B 3 (1%) 266 0.475
(1.00)
0.493
(1.00)
1
(1.00)
0.776
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
ZFHX4 7 (3%) 262 0.916
(1.00)
0.376
(1.00)
0.00978
(1.00)
0.739
(1.00)
1
(1.00)
0.682
(1.00)
0.713
(1.00)
TCN1 4 (1%) 265 0.763
(1.00)
0.284
(1.00)
0.621
(1.00)
1
(1.00)
0.0947
(1.00)
0.146
(1.00)
FLG2 11 (4%) 258 0.212
(1.00)
0.224
(1.00)
0.337
(1.00)
0.65
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
HYDIN 23 (9%) 246 0.494
(1.00)
0.543
(1.00)
0.498
(1.00)
0.175
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
CHD5 8 (3%) 261 0.233
(1.00)
0.269
(1.00)
0.142
(1.00)
0.297
(1.00)
1
(1.00)
1
(1.00)
0.714
(1.00)
TNFSF11 4 (1%) 265 0.685
(1.00)
0.182
(1.00)
0.621
(1.00)
0.73
(1.00)
1
(1.00)
0.593
(1.00)
0.63
(1.00)
TRIML1 7 (3%) 262 0.699
(1.00)
0.317
(1.00)
0.102
(1.00)
0.776
(1.00)
1
(1.00)
0.682
(1.00)
0.713
(1.00)
PLEKHG4B 9 (3%) 260 0.733
(1.00)
0.866
(1.00)
0.291
(1.00)
0.59
(1.00)
1
(1.00)
0.47
(1.00)
0.299
(1.00)
SLIT3 12 (4%) 257 0.293
(1.00)
0.275
(1.00)
0.126
(1.00)
0.0234
(1.00)
1
(1.00)
0.204
(1.00)
0.766
(1.00)
EPHA1 6 (2%) 263 0.601
(1.00)
0.841
(1.00)
1
(1.00)
0.229
(1.00)
0.0682
(1.00)
0.668
(1.00)
1
(1.00)
FAM123C 6 (2%) 263 0.463
(1.00)
0.016
(1.00)
0.424
(1.00)
0.0938
(1.00)
1
(1.00)
0.668
(1.00)
0.674
(1.00)
WNT2 5 (2%) 264 0.773
(1.00)
0.577
(1.00)
0.355
(1.00)
0.407
(1.00)
1
(1.00)
0.183
(1.00)
0.654
(1.00)
NEU4 4 (1%) 265 0.166
(1.00)
0.926
(1.00)
0.135
(1.00)
0.614
(1.00)
1
(1.00)
0.311
(1.00)
0.3
(1.00)
HOMER1 5 (2%) 264 0.758
(1.00)
0.174
(1.00)
0.355
(1.00)
0.776
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
LAMA1 12 (4%) 257 0.58
(1.00)
0.104
(1.00)
0.361
(1.00)
0.517
(1.00)
1
(1.00)
0.111
(1.00)
0.22
(1.00)
KRT23 6 (2%) 263 0.244
(1.00)
0.0952
(1.00)
0.0243
(1.00)
0.756
(1.00)
1
(1.00)
0.668
(1.00)
1
(1.00)
OR5D18 4 (1%) 265 0.789
(1.00)
0.406
(1.00)
0.621
(1.00)
0.0744
(1.00)
1
(1.00)
0.593
(1.00)
1
(1.00)
OR51A2 3 (1%) 266 0.307
(1.00)
0.0742
(1.00)
0.555
(1.00)
1
(1.00)
0.554
(1.00)
0.297
(1.00)
CHL1 8 (3%) 261 0.995
(1.00)
0.315
(1.00)
0.715
(1.00)
0.279
(1.00)
1
(1.00)
0.711
(1.00)
0.714
(1.00)
ELMO1 7 (3%) 262 0.536
(1.00)
0.631
(1.00)
0.705
(1.00)
0.0597
(1.00)
0.101
(1.00)
1
(1.00)
1
(1.00)
PRR21 3 (1%) 266 0.471
(1.00)
0.00892
(1.00)
0.555
(1.00)
0.759
(1.00)
1
(1.00)
0.554
(1.00)
1
(1.00)
PITPNM1 4 (1%) 265 0.118
(1.00)
0.494
(1.00)
0.0162
(1.00)
1
(1.00)
0.593
(1.00)
0.63
(1.00)
DCST2 4 (1%) 265 0.816
(1.00)
0.412
(1.00)
0.621
(1.00)
0.929
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
EEF1A1 5 (2%) 264 0.76
(1.00)
0.532
(1.00)
0.0057
(1.00)
0.903
(1.00)
1
(1.00)
0.653
(1.00)
1
(1.00)
PODNL1 3 (1%) 266 0.0673
(1.00)
0.0372
(1.00)
1
(1.00)
1
(1.00)
0.236
(1.00)
1
(1.00)
TMPRSS6 7 (3%) 262 0.901
(1.00)
0.973
(1.00)
0.257
(1.00)
0.248
(1.00)
1
(1.00)
0.438
(1.00)
0.713
(1.00)
SCN7A 7 (3%) 262 0.0737
(1.00)
0.659
(1.00)
0.705
(1.00)
0.756
(1.00)
1
(1.00)
0.682
(1.00)
0.264
(1.00)
LGI2 4 (1%) 265 0.435
(1.00)
0.676
(1.00)
1
(1.00)
0.776
(1.00)
1
(1.00)
0.311
(1.00)
1
(1.00)
PAN3 6 (2%) 263 0.765
(1.00)
0.314
(1.00)
1
(1.00)
0.616
(1.00)
1
(1.00)
1
(1.00)
0.0874
(1.00)
MSL3 5 (2%) 264 0.591
(1.00)
0.0888
(1.00)
1
(1.00)
0.407
(1.00)
1
(1.00)
0.183
(1.00)
0.654
(1.00)
CTSG 4 (1%) 265 0.636
(1.00)
0.479
(1.00)
0.621
(1.00)
1
(1.00)
0.593
(1.00)
0.63
(1.00)
UBE2NL 3 (1%) 266 0.939
(1.00)
0.0492
(1.00)
0.296
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
SULT1B1 4 (1%) 265 0.48
(1.00)
0.616
(1.00)
0.621
(1.00)
0.929
(1.00)
1
(1.00)
1
(1.00)
0.63
(1.00)
CYLC2 4 (1%) 265 0.0213
(1.00)
0.933
(1.00)
1
(1.00)
0.229
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
CYP4F22 5 (2%) 264 0.624
(1.00)
0.921
(1.00)
1
(1.00)
0.331
(1.00)
1
(1.00)
0.653
(1.00)
0.364
(1.00)
EIF2C3 5 (2%) 264 0.523
(1.00)
0.141
(1.00)
1
(1.00)
0.614
(1.00)
1
(1.00)
0.653
(1.00)
0.654
(1.00)
GALK2 5 (2%) 264 0.642
(1.00)
0.431
(1.00)
0.657
(1.00)
0.513
(1.00)
0.0345
(1.00)
1
(1.00)
1
(1.00)
GFM1 3 (1%) 266 0.788
(1.00)
0.386
(1.00)
1
(1.00)
0.776
(1.00)
1
(1.00)
0.554
(1.00)
0.297
(1.00)
KPRP 7 (3%) 262 0.688
(1.00)
0.144
(1.00)
0.257
(1.00)
0.508
(1.00)
1
(1.00)
1
(1.00)
0.713
(1.00)
DSG3 8 (3%) 261 0.178
(1.00)
0.863
(1.00)
1
(1.00)
0.757
(1.00)
1
(1.00)
0.442
(1.00)
1
(1.00)
ACSL6 4 (1%) 265 0.227
(1.00)
0.318
(1.00)
1
(1.00)
0.614
(1.00)
1
(1.00)
0.311
(1.00)
1
(1.00)
AFM 5 (2%) 264 0.926
(1.00)
0.447
(1.00)
1
(1.00)
0.929
(1.00)
1
(1.00)
0.33
(1.00)
0.654
(1.00)
OR7G2 5 (2%) 264 0.000983
(1.00)
0.909
(1.00)
1
(1.00)
0.407
(1.00)
1
(1.00)
0.183
(1.00)
1
(1.00)
CHRM2 4 (1%) 265 0.343
(1.00)
0.345
(1.00)
0.621
(1.00)
0.576
(1.00)
1
(1.00)
0.593
(1.00)
0.3
(1.00)
PTPRT 9 (3%) 260 0.582
(1.00)
0.813
(1.00)
0.291
(1.00)
0.59
(1.00)
0.0847
(1.00)
0.28
(1.00)
1
(1.00)
MAGEB6 5 (2%) 264 0.368
(1.00)
0.704
(1.00)
0.355
(1.00)
0.346
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
CALCR 6 (2%) 263 0.597
(1.00)
0.54
(1.00)
1
(1.00)
0.959
(1.00)
1
(1.00)
1
(1.00)
0.417
(1.00)
TJAP1 5 (2%) 264 0.743
(1.00)
0.921
(1.00)
0.0584
(1.00)
0.311
(1.00)
1
(1.00)
1
(1.00)
0.654
(1.00)
GPC4 5 (2%) 264 0.434
(1.00)
0.182
(1.00)
1
(1.00)
0.885
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
QPRT 3 (1%) 266 0.983
(1.00)
0.251
(1.00)
0.555
(1.00)
0.776
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
AADACL4 5 (2%) 264 0.524
(1.00)
0.327
(1.00)
0.657
(1.00)
0.146
(1.00)
1
(1.00)
0.33
(1.00)
1
(1.00)
KIAA1751 7 (3%) 262 0.0248
(1.00)
0.4
(1.00)
1
(1.00)
0.513
(1.00)
1
(1.00)
1
(1.00)
0.264
(1.00)
PLCB3 5 (2%) 264 0.701
(1.00)
0.457
(1.00)
0.0584
(1.00)
0.346
(1.00)
1
(1.00)
0.33
(1.00)
0.161
(1.00)
MEGF8 10 (4%) 259 0.796
(1.00)
0.141
(1.00)
0.503
(1.00)
0.664
(1.00)
1
(1.00)
0.0336
(1.00)
0.0966
(1.00)
OR5I1 4 (1%) 265 0.82
(1.00)
0.118
(1.00)
1
(1.00)
0.776
(1.00)
1
(1.00)
1
(1.00)
0.63
(1.00)
CLCN7 3 (1%) 266 0.643
(1.00)
0.167
(1.00)
1
(1.00)
0.515
(1.00)
1
(1.00)
0.554
(1.00)
1
(1.00)
IL4R 6 (2%) 263 0.25
(1.00)
0.706
(1.00)
0.193
(1.00)
0.407
(1.00)
1
(1.00)
0.0815
(1.00)
0.674
(1.00)
TXNDC3 6 (2%) 263 0.89
(1.00)
0.515
(1.00)
1
(1.00)
0.756
(1.00)
1
(1.00)
1
(1.00)
0.417
(1.00)
UGT2A3 3 (1%) 266 0.917
(1.00)
0.123
(1.00)
1
(1.00)
1
(1.00)
0.554
(1.00)
0.557
(1.00)
FANK1 4 (1%) 265 0.682
(1.00)
0.954
(1.00)
0.621
(1.00)
0.776
(1.00)
1
(1.00)
0.0947
(1.00)
0.146
(1.00)
KCNH5 7 (3%) 262 0.568
(1.00)
0.705
(1.00)
0.705
(1.00)
0.495
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
OR2T27 4 (1%) 265 0.735
(1.00)
0.988
(1.00)
0.135
(1.00)
0.776
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
RBMS3 5 (2%) 264 0.573
(1.00)
0.389
(1.00)
0.355
(1.00)
0.963
(1.00)
1
(1.00)
0.33
(1.00)
0.654
(1.00)
WDR92 4 (1%) 265 0.694
(1.00)
0.952
(1.00)
0.621
(1.00)
0.229
(1.00)
1
(1.00)
1
(1.00)
0.63
(1.00)
NUP210L 9 (3%) 260 0.982
(1.00)
0.24
(1.00)
0.727
(1.00)
0.266
(1.00)
0.117
(1.00)
0.724
(1.00)
1
(1.00)
OR4D5 4 (1%) 265 0.53
(1.00)
0.0949
(1.00)
0.3
(1.00)
0.759
(1.00)
1
(1.00)
0.0947
(1.00)
0.146
(1.00)
CDKN1B 3 (1%) 266 0.82
(1.00)
0.513
(1.00)
1
(1.00)
0.311
(1.00)
1
(1.00)
1
(1.00)
0.297
(1.00)
THSD7B 7 (3%) 262 0.0477
(1.00)
0.0359
(1.00)
0.428
(1.00)
0.508
(1.00)
1
(1.00)
1
(1.00)
0.713
(1.00)
ANKRD52 6 (2%) 263 0.716
(1.00)
0.21
(1.00)
1
(1.00)
0.248
(1.00)
1
(1.00)
0.384
(1.00)
0.199
(1.00)
DPP10 7 (3%) 262 0.993
(1.00)
0.262
(1.00)
0.257
(1.00)
0.132
(1.00)
1
(1.00)
1
(1.00)
0.264
(1.00)
PHLDB2 5 (2%) 264 0.37
(1.00)
0.85
(1.00)
1
(1.00)
1
(1.00)
0.183
(1.00)
0.364
(1.00)
PCDH11Y 5 (2%) 264 0.983
(1.00)
0.763
(1.00)
0.163
(1.00)
0.508
(1.00)
1
(1.00)
0.183
(1.00)
0.364
(1.00)
DCHS1 9 (3%) 260 0.251
(1.00)
0.427
(1.00)
0.727
(1.00)
0.317
(1.00)
1
(1.00)
0.28
(1.00)
1
(1.00)
KCNA4 5 (2%) 264 0.499
(1.00)
0.559
(1.00)
0.0584
(1.00)
1
(1.00)
0.33
(1.00)
0.654
(1.00)
LRRIQ1 8 (3%) 261 0.155
(1.00)
0.933
(1.00)
1
(1.00)
0.115
(1.00)
1
(1.00)
0.711
(1.00)
0.714
(1.00)
PCDH11X 5 (2%) 264 0.442
(1.00)
0.11
(1.00)
0.355
(1.00)
0.0224
(1.00)
1
(1.00)
0.183
(1.00)
0.364
(1.00)
REPIN1 3 (1%) 266 0.177
(1.00)
0.725
(1.00)
0.296
(1.00)
1
(1.00)
0.554
(1.00)
1
(1.00)
SSPO 10 (4%) 259 0.394
(1.00)
0.232
(1.00)
0.751
(1.00)
0.757
(1.00)
1
(1.00)
0.73
(1.00)
1
(1.00)
ZNF493 3 (1%) 266 0.147
(1.00)
0.402
(1.00)
1
(1.00)
1
(1.00)
0.554
(1.00)
0.297
(1.00)
FRRS1 6 (2%) 263 0.372
(1.00)
0.609
(1.00)
0.424
(1.00)
0.508
(1.00)
1
(1.00)
1
(1.00)
0.417
(1.00)
MICAL1 4 (1%) 265 0.524
(1.00)
0.254
(1.00)
0.135
(1.00)
0.146
(1.00)
1
(1.00)
1
(1.00)
1
(1.00)
OR4P4 4 (1%) 265 0.27
(1.00)
0.932
(1.00)
1
(1.00)
0.776
(1.00)
1
(1.00)
0.311
(1.00)
0.63
(1.00)
RFX6 7 (3%) 262 0.751
(1.00)
0.635
(1.00)
0.705
(1.00)
0.631
(1.00)
0.0847
(1.00)
0.682
(1.00)
0.264
(1.00)
DEFB114 3 (1%) 266 0.621
(1.00)
0.744
(1.00)
0.046
(1.00)
1
(1.00)
1
(1.00)
0.297
(1.00)
SYDE2 4 (1%) 265 0.00793
(1.00)
0.333
(1.00)
0.621
(1.00)
0.929
(1.00)
1
(1.00)
0.593
(1.00)
0.63
(1.00)
DYNC1I1 7 (3%) 262 0.953
(1.00)
0.694
(1.00)
0.0516
(1.00)
0.634
(1.00)
1
(1.00)
1
(1.00)
0.713
(1.00)
'IDH1 MUTATION STATUS' versus 'AGE'

P value = 2.36e-05 (t-test), Q value = 0.048

Table S1.  Gene #1: 'IDH1 MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 269 60.6 (13.2)
IDH1 MUTATED 15 41.1 (13.1)
IDH1 WILD-TYPE 254 61.8 (12.3)

Figure S1.  Get High-res Image Gene #1: 'IDH1 MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'ZNF704 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S2.  Gene #25: 'ZNF704 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
ZNF704 MUTATED 3 80.0 (0.0)
ZNF704 WILD-TYPE 205 75.4 (15.4)

Figure S2.  Get High-res Image Gene #25: 'ZNF704 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'ZNF784 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S3.  Gene #31: 'ZNF784 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
ZNF784 MUTATED 3 80.0 (0.0)
ZNF784 WILD-TYPE 205 75.4 (15.4)

Figure S3.  Get High-res Image Gene #31: 'ZNF784 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'PUF60 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.061

Table S4.  Gene #36: 'PUF60 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
PUF60 MUTATED 4 80.0 (0.0)
PUF60 WILD-TYPE 204 75.4 (15.4)

Figure S4.  Get High-res Image Gene #36: 'PUF60 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'GUF1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S5.  Gene #40: 'GUF1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
GUF1 MUTATED 3 80.0 (0.0)
GUF1 WILD-TYPE 205 75.4 (15.4)

Figure S5.  Get High-res Image Gene #40: 'GUF1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'C1ORF187 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S6.  Gene #53: 'C1ORF187 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
C1ORF187 MUTATED 3 80.0 (0.0)
C1ORF187 WILD-TYPE 205 75.4 (15.4)

Figure S6.  Get High-res Image Gene #53: 'C1ORF187 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'EIF4A3 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S7.  Gene #55: 'EIF4A3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
EIF4A3 MUTATED 3 80.0 (0.0)
EIF4A3 WILD-TYPE 205 75.4 (15.4)

Figure S7.  Get High-res Image Gene #55: 'EIF4A3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'RBM3 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S8.  Gene #59: 'RBM3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
RBM3 MUTATED 3 80.0 (0.0)
RBM3 WILD-TYPE 205 75.4 (15.4)

Figure S8.  Get High-res Image Gene #59: 'RBM3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'FOXF1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S9.  Gene #70: 'FOXF1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
FOXF1 MUTATED 3 80.0 (0.0)
FOXF1 WILD-TYPE 205 75.4 (15.4)

Figure S9.  Get High-res Image Gene #70: 'FOXF1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'PRKRIP1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S10.  Gene #75: 'PRKRIP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
PRKRIP1 MUTATED 3 80.0 (0.0)
PRKRIP1 WILD-TYPE 205 75.4 (15.4)

Figure S10.  Get High-res Image Gene #75: 'PRKRIP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'OR5W2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.061

Table S11.  Gene #86: 'OR5W2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
OR5W2 MUTATED 5 80.0 (0.0)
OR5W2 WILD-TYPE 203 75.4 (15.5)

Figure S11.  Get High-res Image Gene #86: 'OR5W2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CHEK1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S12.  Gene #96: 'CHEK1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
CHEK1 MUTATED 3 80.0 (0.0)
CHEK1 WILD-TYPE 205 75.4 (15.4)

Figure S12.  Get High-res Image Gene #96: 'CHEK1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'C21ORF58 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S13.  Gene #98: 'C21ORF58 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
C21ORF58 MUTATED 3 80.0 (0.0)
C21ORF58 WILD-TYPE 205 75.4 (15.4)

Figure S13.  Get High-res Image Gene #98: 'C21ORF58 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'SLC4A11 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S14.  Gene #123: 'SLC4A11 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
SLC4A11 MUTATED 3 80.0 (0.0)
SLC4A11 WILD-TYPE 205 75.4 (15.4)

Figure S14.  Get High-res Image Gene #123: 'SLC4A11 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'ARID3B MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S15.  Gene #129: 'ARID3B MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
ARID3B MUTATED 3 80.0 (0.0)
ARID3B WILD-TYPE 205 75.4 (15.4)

Figure S15.  Get High-res Image Gene #129: 'ARID3B MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'MTMR7 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S16.  Gene #131: 'MTMR7 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
MTMR7 MUTATED 3 80.0 (0.0)
MTMR7 WILD-TYPE 205 75.4 (15.4)

Figure S16.  Get High-res Image Gene #131: 'MTMR7 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'DSCAM MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.01e-05 (t-test), Q value = 0.061

Table S17.  Gene #135: 'DSCAM MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
DSCAM MUTATED 7 80.0 (0.0)
DSCAM WILD-TYPE 201 75.3 (15.5)

Figure S17.  Get High-res Image Gene #135: 'DSCAM MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'KRT13 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S18.  Gene #149: 'KRT13 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
KRT13 MUTATED 3 80.0 (0.0)
KRT13 WILD-TYPE 205 75.4 (15.4)

Figure S18.  Get High-res Image Gene #149: 'KRT13 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CDKN2C MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S19.  Gene #158: 'CDKN2C MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
CDKN2C MUTATED 3 80.0 (0.0)
CDKN2C WILD-TYPE 205 75.4 (15.4)

Figure S19.  Get High-res Image Gene #158: 'CDKN2C MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'RAG1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S20.  Gene #185: 'RAG1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
RAG1 MUTATED 3 80.0 (0.0)
RAG1 WILD-TYPE 205 75.4 (15.4)

Figure S20.  Get High-res Image Gene #185: 'RAG1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'JHDM1D MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S21.  Gene #194: 'JHDM1D MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
JHDM1D MUTATED 3 80.0 (0.0)
JHDM1D WILD-TYPE 205 75.4 (15.4)

Figure S21.  Get High-res Image Gene #194: 'JHDM1D MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'LMO1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S22.  Gene #214: 'LMO1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
LMO1 MUTATED 3 80.0 (0.0)
LMO1 WILD-TYPE 205 75.4 (15.4)

Figure S22.  Get High-res Image Gene #214: 'LMO1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'NFKBIL2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.061

Table S23.  Gene #218: 'NFKBIL2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
NFKBIL2 MUTATED 4 80.0 (0.0)
NFKBIL2 WILD-TYPE 204 75.4 (15.4)

Figure S23.  Get High-res Image Gene #218: 'NFKBIL2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'JAG2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S24.  Gene #220: 'JAG2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
JAG2 MUTATED 3 80.0 (0.0)
JAG2 WILD-TYPE 205 75.4 (15.4)

Figure S24.  Get High-res Image Gene #220: 'JAG2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CXCL6 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S25.  Gene #222: 'CXCL6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
CXCL6 MUTATED 3 80.0 (0.0)
CXCL6 WILD-TYPE 205 75.4 (15.4)

Figure S25.  Get High-res Image Gene #222: 'CXCL6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CCDC105 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.061

Table S26.  Gene #223: 'CCDC105 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
CCDC105 MUTATED 4 80.0 (0.0)
CCDC105 WILD-TYPE 204 75.4 (15.4)

Figure S26.  Get High-res Image Gene #223: 'CCDC105 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'SPAM1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.01e-05 (t-test), Q value = 0.061

Table S27.  Gene #238: 'SPAM1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
SPAM1 MUTATED 6 80.0 (0.0)
SPAM1 WILD-TYPE 202 75.3 (15.5)

Figure S27.  Get High-res Image Gene #238: 'SPAM1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CTDSP1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S28.  Gene #245: 'CTDSP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
CTDSP1 MUTATED 3 80.0 (0.0)
CTDSP1 WILD-TYPE 205 75.4 (15.4)

Figure S28.  Get High-res Image Gene #245: 'CTDSP1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'TLR6 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S29.  Gene #247: 'TLR6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
TLR6 MUTATED 3 80.0 (0.0)
TLR6 WILD-TYPE 205 75.4 (15.4)

Figure S29.  Get High-res Image Gene #247: 'TLR6 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'OPRM1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S30.  Gene #252: 'OPRM1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
OPRM1 MUTATED 3 80.0 (0.0)
OPRM1 WILD-TYPE 205 75.4 (15.4)

Figure S30.  Get High-res Image Gene #252: 'OPRM1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'GJB1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S31.  Gene #255: 'GJB1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
GJB1 MUTATED 3 80.0 (0.0)
GJB1 WILD-TYPE 205 75.4 (15.4)

Figure S31.  Get High-res Image Gene #255: 'GJB1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'TGM3 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.02e-05 (t-test), Q value = 0.061

Table S32.  Gene #264: 'TGM3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
TGM3 MUTATED 5 80.0 (0.0)
TGM3 WILD-TYPE 203 75.4 (15.5)

Figure S32.  Get High-res Image Gene #264: 'TGM3 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'LEFTY1 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S33.  Gene #269: 'LEFTY1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
LEFTY1 MUTATED 3 80.0 (0.0)
LEFTY1 WILD-TYPE 205 75.4 (15.4)

Figure S33.  Get High-res Image Gene #269: 'LEFTY1 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

'CHP2 MUTATION STATUS' versus 'KARNOFSKY.PERFORMANCE.SCORE'

P value = 3.03e-05 (t-test), Q value = 0.061

Table S34.  Gene #295: 'CHP2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

nPatients Mean (Std.Dev)
ALL 208 75.5 (15.3)
CHP2 MUTATED 3 80.0 (0.0)
CHP2 WILD-TYPE 205 75.4 (15.4)

Figure S34.  Get High-res Image Gene #295: 'CHP2 MUTATION STATUS' versus Clinical Feature #4: 'KARNOFSKY.PERFORMANCE.SCORE'

Methods & Data
Input
  • Mutation data file = GBM.mutsig.cluster.txt

  • Clinical data file = GBM.clin.merged.picked.txt

  • Number of patients = 269

  • Number of significantly mutated genes = 295

  • Number of selected clinical features = 7

  • Exclude genes that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Student's t-test analysis

For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene mutations using 't.test' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)
[3] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[4] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)